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Clinical effectiveness and cost-effectiveness of laparoscopic

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					Preference Elicitation and Assessment of Technologies
(PEAT) Programme
Project No:               B1.54                                               Projects completed

Project Title:            Systematic review of the effectiveness and cost-effectiveness of
                          laparoscopic surgery for colorectal cancer.

Grant Applicants /        Murray, A., Lourenco, T., Fraser, C., Grant, A. (HSRU, University of
Principal Investigators   Aberdeen) McKinley, A. and Krukowski, Z. (Department of Surgery,
(place of work):          Aberdeen Royal Infirmary)

HERU Investigators:       Vale, L., de Verteuil, R. and Hernández, R.

HERU Research             Assessment of Technologies
Theme:

Source of Funding and     Department of Health - £146,640
Total Awarded:

Amount of HERU            £22,093
Funding:

Objectives:               To assess the effectiveness and cost-effectiveness of laparoscopic
                          surgery for the treatment of cancer of colorectal cancer.

Outline:                  Colorectal cancer is one of the most common cancers of the Western
                          world. The only curative measure is surgical resection of the disease
                          which, in the UK, is conducted using an open technique associated
                          with high morbidity rates. An alternative to this method is laparoscopic
                          surgery which provides a minimally invasive technique and may,
                          therefore, be associated with short-term quality of life gains. The study
                          investigated, using the methods of systematic review and economic
                          evaluation, the effectiveness and cost-effectiveness of laparoscopic
                          surgery for colorectal cancer.

Outcome and               Cost-effectiveness was found to depend upon judgements about the
Translation:              balance between additional cost, shorter recovery and apparently
                          similar long-term effectiveness at three years. Based on the data
                          presented, NICE concluded that laparoscopic surgery was, along with
                          open surgery,
                                 worthwhile to provide on the NHS.
                           http://www.nice.org.uk/nicemedia/pdf/TA105guidance.pdf)

Start Date:               April 2005
Duration of Project:      8 months

Project Phase:

Publications:             Murray, A., Lourenco, T., de Verteuil, R., Hernández, R., Fraser, C.,
                          McKinley, A., Krukowski, Z., Vale, L. and Grant, A. Clinical
                      effectiveness and cost-effectiveness of laparoscopic surgery for
                      colorectal cancer: systematic reviews and economic evaluation. Health
                      Technology Assessment. 2006; 10(45).

                      de Verteuil, R., Hernández, R. and Vale, L. on behalf of Aberdeen
                      HTA Group. Economic evaluation of laparoscopic surgery for
                      colorectal cancer. International Journal of Technology Assessment in
                      Health Care. 2007; 23(4): 464-472.

                      Hernández, R., de Verteuil, R., Fraser, C., and Vale, L. on behalf of
                      the Aberdeen Health Technology Assessment Group. Systematic
                      review of economic evaluations of laparoscopic surgery for colorectal
                      cancer. Colorectal Disease. 2008; 10(9): 859-868.

                      Lourenco, T., Murray, A., Grant, A., McKinley, A., Krukowski, Z. and
                      Vale, L. Laparoscopic surgery for colorectal cancer: safe and
                      effective? – A systematic review. Surgical Endoscopy. 2008; 22(5):
                      1146-1160.

                      Murray. A., Lourenco, T., de Verteuil, R., Hernández, R., Fraser, C.,
                      McKinley, A., Krukowski, Z., Vale, L. and Grant, A. Systematic
                      review of the clinical effectiveness and cost-effectiveness of
                      laparoscopic surgery for colorectal cancer. Report to the National
                      Institute for Health and Clinical Excellence, April 2006.

                      de Verteuil, R. The cost effectiveness of laparoscopic surgery for
                      colorectal cancer. HERU Briefing Paper, University of Aberdeen.
                      October 2007.

Other Dissemination   de Verteuil, R., Hernández, R. and Vale, L. Economic evaluation of
Activities:           laparoscopic surgery for colorectal cancer. 2nd Annual Meeting Health
                      Services Research Network Conference, Sheffield, June 2007.

                      de Verteuil, R., Hernández, R. and Vale, L. Economic evaluation of
                      laparoscopic surgery for colorectal cancer. Operational Research
                      Modelling Conference, Edinburgh, September 2007.

                      Murray, A., de Verteuil, R. and Vale, L. 1st Consultee Meeting on
                      Review of laparoscopic surgery for colorectal cancer. National
                      Institute for Health and Clinical Excellence (NICE), London, May
                      2005.

                      de Verteuil, R., Hernández, R. and Vale, L. Economic evaluation of
                      laparoscopic surgery for colorectal cancer. HTAi. Barcelona, June
                      2007.

				
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