Dataset S2
Distribution of C. albicans proteins containing CUG-encoded residues by functional categories.
The proteins were clustered according to the relationship between the GO terms. Proteins containing serine-
and leucine-CUG encoded residues located in strictly conserved positions are highlighted in red and cyan,
respectively.
Biological process GO term Proteins
Cellular process 172
ARC35 ARP3 BEM2 BNI1 CDC10
CDC11 END3 MHP1 MSS4 MYO5
Actin cytoskeleton SCP1 SEP7 SLA1 SLA2 SPA2
organization TUB4 WAL1 17
AGP2 AGP3 ALR1 CAF16 CAN2
CCC1 CCC2 CCH1 CNH1 DAL4
DAL5 DIP5 ENA2 FLC1 FLC2
FTH1 GNP1 GUP1 HST6 HUT1
IFC3 JEN1 MAC1 MAL31 MDL1
MEP1 MID1 MNR2 MODF MRS2
MUP1 NAG6 OPT1 OPT8 PHM7
PHO91 PMC1 PTH1 PXA1 SIT1
SMF3 SMF12 SNF3 SUL2 SSU1
SSY1 TOK1 PO3 TPO4 UGA4
Transmembrane transport GO:0055085 YOR1 YVC1 52
APL5 AVT7 BET2 BUD7 EXO70
GEA2 MEX67 MSN5 MTR2
MTR10 NMD3 NMD5 NUP49
NUP60 NUP85 NUP1888 PDR6
PEP8 RET2 SAC3 SEC12 SEC14
SEC18 SEC23 SEC34 TRS33
SEC61 SFT1 SYS1 SYS3 VPS2
VPS4 VPS8 VPS24 VPS28 VPS33
Intracellular transport GO:0046907 YHM2 37
Protein localization GO:0034613 BUD6 RCY1 RVS167 SPC3 4
ATP7 COX13 CYB2 CYC3 DIT2
Respiratory chain GO:0022904 QCR2 SDH1 SHY1 8
BEM1 CAS4 CBK1 CDC3 CDC5
CDC14 CDC20 CDC23 CDC45
CDC54 CLB2 CLN3 CMC3 CSE4
DNA2 DBF4 ENG1 EST1 HCM1
HRT1 IPL1 KEL1 KIC1 KIN3 KIP2
MAD2 MCM6 MIF2 ORC3 ORC4
PDE1 POL2 POL5 PRI2 RAX1
RNH35 SDS22 SFI1 SGS1 SWE1
Cell cycle GO:0007049 SMC1 SMC2 TOP2 43
CGR1 CKB1 CKB2 DEM1 DFG10
Cell growth GO:0016049 ELF1 KOG1 YVH1 8
Cell aging GO:0007569 PBP2 SGS1 TERT 3
Regulation of cellular process 162
ARP9 ASF1 CDC68 DOT6 HOS1
HOS2 HOS3 ISW2 MCD1 PHO23
SET1 SET3 SIN3 SNF2 VID21
Chromatin modification GO:0016568 YAF9 16
ACE2 ADA2 ADR1 ARG81 ARO80
ASG1 BDF1 CAS1 CAS4 CAT8
CCR4 CDC39 CTA1 CTA3 CTA7
CWT1 DAL81 FKH2 HCM1 LEU3
LYS14 MAC1 MAF1 MED8 MSB1
PDC2 PPR1 PUT3 REG1 RLM1
SEF1 SIN3 SKO1 SPT5 SPT6
SPT14 SRB9 SSN6 SSN8 STB3
STB5 SUA71 TEA1 TFG1 TSM1
UGA3 UPC2 WAR1 WOR1
Regulation of transcription GO:0045449 ZCF11 50
mRNA catabolic process 6397 NAM7 SUV3 2
BCK1 BCY1 BEM2 BEM3 BUD2
CAG1 CBK1 CDC5 CDC24 CEK1
CKA1 CKB1 CKB2 CLA4 CMD1
CRL1 CPP1 CSC25 CSK1 CYR1
FUN31 GYP1 GYP2 GYP7 GPA2
HOG1 HSL1 HST7 IRA2 KIS1
KNS1 LEM3 MKK2 MSB2 MSS4
PBS2 PDE1 PIKA PLC1 PTK2 PTP1
PTP3 RAS1 RCK2 RDI1 RGA2
RGD1 RHB1 ROM2 SAC7 SCH9
SKN7 SLN1 SNF1 SNF4 SYG1
Signal transduction GO:0007165 SST2 STE4 TPK2 VAC7 60
APC1 APG7 ATG9 ATG15 BRE1
BRO1 CDC4 CDC23 CDC37
CDC43 CPR6 CPY1 DAP2 DDI1
DOA4 GIM5 HRT1 LAP3 LAP41
MUB1 NOT4 NOT5 NPL4 NPR1
PEP1 RAD6 RAD16 RMS1 ROD1
Proteolysis GO:0006508 SPO72 TOM1 UBP1 UBR1 VTC4 34
Cellular component biogenesis 109
ADA2 ACF2 AGM1 AKR1 ALG5
ALG6 ALG7 ALG9 BEM2 BUD7
CAS4 CBK1 CDC43 CHS1 CHS2
CHS4 CHT3 CHT4 CRH11 CWT1
ECM3 ECM7 ECM17 ECM21
ECM29 ECM39 ENG1 HCA4 KIC1
KRE6 KTR2 KTR4 MNN1 MNN11
MNS1 MNT2 MSB2 OCH1 PGA5
PGA52 PHR3 PLB3 PLC1 PMR1
PMT2 PMT4 RHB1 RLM1 RMS1
ROT1 ROT2 SKO1 SLN1 SMP3
Cell wall organization SPO1 SPT14 SSN8 SSD1 VAN1
biogenesis GO: 0070882 VPS28 VRG4 XOG1 XYL2 YEA4 64
BLM3 HBR3 PR26 PRE6 PRE8
RPN1 RPN3 RPN5 RPN6 RPN7
26S proteasome assembly GO:0043248 RPN8 11
BMS1 DIP2 HBR3 HCA4 KRR1
MAK5 MPP10 MRP8 MRP20
MRPL10 MRPS9 NEP1 NOP4
Ribosome biogenesis and NOP5 NRP1 POP4 RCL1 RPL7
assembly GO:0042254 RRP8 SAS10 SPB4 YML6 YTM1 23
ATS1 LIG1 NBP35 POP4 PUS4
tRNA processing GO:0008033 PUS7 RIT1 SPL1 TRM9 9
Vacuolar organization GO:0007033 VPS11 VPS41 2
Metabolic process 134
ARE2 AUR1 AYR1 BTS1 CDS1
CEM1 CHO2 EHT1 ERG4 ERG5
ERG8 ERG11 ERG24 ERG25
ERG26 ERG27 FAA21 FAS2 FAT1
GPI1 GPI7 GPI13 IFE1 IPK1 IPK2
IPT1 ISC1 KSR1 LAG1 MCD4
MIT1 MUQ1 NCR1 OSH3 PEL1
PEX5 PLC1 SMP2 PLD1 SCT1
SUR2 TLG2 TSC11 UGT51C1
Lipid metabolic process GO:0044255 UPC2 VAC7 46
AMS1 ATC1 DAK2 FBP1 GDB1
GSY1 KIS1 NTH1 PFK1 PFK2
Carbohydrate metabolic PFK26 PYC2 RBK1 REG1 SGA1
process GO:0005975 SNF1 TPS2 TPS3 UAP1 19
ABZ1 ARG2 ARG4 ARG5.6 ARG8
ARG11 ARG81 ARO1 ARO8
ARO9 ARO10 ARO80 DFR1
ECM42 FOL1 GDH2 GSH2 HAL22
HIS4 HIS5 HOM3 ILV1 ILV3 LEU3
LEU4 LYS4 LYS14 MET1 MET2
MET3 PRO1 PRS5 PUT3 SAM4
Amino acid and derivative SHM2 SPE1 SNO1 THR1 THR4
metabolic process GO:0006519 TRP1 TRP3 TYR1 42
ADE4 ADE6 ADE8 ADE12 ADE13
Nucleotide metabolic CDC21 FIL1 HNT2 PPR1 PYC2
process GO:0009117 URA3 URK1 12
COQ3 CTN3 HEM1 HEM3
HEM14 HMX1 NAR1 NBP35
Cofactor metabolic process GO:0051186 PDX3 THI6 THI20 11
Phosphate metabolic
process GO:0006796 PHM5 PHO81 VTC3 VTC4 4
Gene expression 52
RPA12 RRN3 RPO21 RPO41
Transcription GO:0006351 SHA3 TBP1 6
ABD1 CET1 CGT1 EXM2 FAL1
LEA1 PAN3 PAP1 POP4 PRP5
RNA processing 6397 PRP8 PRP22 SLU7 SNU114 YTH1 15
ALA1 CDC60 DED81 EIF4E
FUN12 GCD2 GCD7 GCN1 GCN2
GCN3 GLE1 IFM1 ILS1 MEF2
MSK1 MSM1 MSW1 NAM2 PRS
PRT1 RIA1 RPG1A RTS1 SES1
Translation GO:0006412 TIF4631 TYS1 26
Protein maturation GO:0016485 ERO1 HCH1 STI1 TCP1 YKE2 5
Response to stress 93
APN2 DNA2 DDC1 DUN1 GIN1
HAM1 MEC1 MEC3 MET18
MPH1 MSH2 MSH6 NPL6 RAD2
RAD7 RAD14 RAD16 RAD32
RAD50 RAD52 RAD54 RAD57
RAT1 RDH54 REV3 RFA1 RFC1
DNA repair GO:0006281 RFC4 VID21 YAF9 YBL053 31
Response to stress GO:0006950 RIM11 SKO1 TOR1 TPK2 VID27 5
AHP1 CCP1 DOT5 GLR1 GSH2
HOG1 MAD2 MCA1 NAR1 OXR1
PBS2 POS5 RAD50 SKN7 TPS2
Response to oxidative stress GO:0006979 TPS3 16
GPD1 HOG1 MSB2 NTH1 PBS2
RCK2 RGD1 RIM8 RIM20 RIM21
SKN7 SLN1 SGD1 TPS2 TPS3
Response to osmotic stress GO:0006970 VPS28 VRP1 WAR1 18
ATM1 BMS1 CAR2 CTA1 HOG1
NAG6 NOP4 OPT1 PDR16 PLC1
PMC1 PMT2 PMT4 QDR1 RAD32
RAD50 SAS10 SIT1 TPO3 TPO4
Response to drug GO:0042493 VPS28 YCF1 YOR1 23
Virulence factors involved in pathogenesis 164
ACE2 ADE8 ADE12 AGP3 AHP1
CAS1 CIS2 CLN3 ERG25 ELF1
ECM17 FAT1 FIL1 GCS1 GPD1
HAL22 HCA4 IVL3 KEM1 KRR1
MET3 NUP85 PEL1 PLC1 PMT2
PMT4 POL5 PTK2 PUS4 SPE1
SUL2 SUR2 SYS3 SPT14 SUV3
Biofilm formation GO:0042710 STI1 36
ACE2 ATS1 BUB2 CDC10 CYC3
DPJ1 HYU1 HIS4 MNT2 MSB1
NOT5 PDE1 PRA1 PRP5 PRP22
RPA12 SET1 SYS3 TUB4 WOR1
Biological adhesion GO:0022610 YML6 21
ACE2 ADR1 ARP3 BCY1 CBK1
CCH1 CCR4 CDC4 CDC5 CDC24
CDC39 CDS1 CEK1 CLN3 CSC25
CYR1 DDC1 DUR1.2 ERG25
ECM29 FAB1 FKH2 FLC1 GIN1
GPA2 GYP7 HSL1 HST7 KAR3
KEL1 KEM1 KEX2 LIG4 MHP1
MID1 MUC1 MYO5 NOT4 NOT5
OSH3 PEP8 PLD1 PMR1 PMT2
PMT4 RAD6 RAS1 RAV2 RAX1
RAX2 RHB1 RIM8 RIM20 RIM21
RPO41 SCH9 SEP7 SKN7 SET1
SET3 SIN3 SHA3 SNF1 SNF2
SNF4 SPT5 SPT6 SRB9 SRO77
SSN6 SSU1 SUV3 TFG1 TIF4631
TPK2 TSC11 VAC8 VID27 VPS11
VPS28 VRG4 WHI3 YTA6 YTM1
Morphogenesis GO:0030447 YVH1 ZCF11 86
RG11 CAG1 CEK1 EMC9 FAR1
FIG1 FMP45 HBR1 HST6 HST7
KAR3 MPT5 PRM1 RCE1 RMS1
SNX4 SST2 STE3 STE4 STE13
Mating GO:0007618 STE23 21