Retinoblastoma - Pipeline Review, H2 2011

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					Retinoblastoma – Pipeline Review, H2 2011




                    Retinoblastoma - Pipeline Review, H2 2011
                                                                                          Reference Code: GMDHC1470IDB

                                                                                          Publication Date: October 2011




Retinoblastoma – Pipeline Review, H2 2011                                                                        GMDHC1470IDB / Pub October 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                                                  Page(1)
Retinoblastoma – Pipeline Review, H2 2011



Ta b le o f Co n te n ts
Table of Contents ..................................................................................................................................................................................................... 2
      List of Tables...................................................................................................................................................................................................... 4
      List of Figures .................................................................................................................................................................................................... 5
Introduction .............................................................................................................................................................................................................. 6
      Global Markets Direct Report Coverage ............................................................................................................................................................. 6
Retinoblastoma Overview ......................................................................................................................................................................................... 7
Therapeutics Development ....................................................................................................................................................................................... 8
      An Overview of Pipeline Products for Retinoblastoma ........................................................................................................................................ 8
Retinoblastoma Therapeutics under Development by Companies ...........................................................................................................................10
Retinoblastoma Therapeutics under Investigation by Universities/Institutes.............................................................................................................11
Late Stage Products ................................................................................................................................................................................................13
      Comparative Analysis .......................................................................................................................................................................................13
Mid Clinical Stage Products .....................................................................................................................................................................................14
      Comparative Analysis .......................................................................................................................................................................................14
Early Clinical Stage Products ..................................................................................................................................................................................15
      Comparative Analysis .......................................................................................................................................................................................15
Pre-Clinical Stage Products .....................................................................................................................................................................................16
      Comparative Analysis .......................................................................................................................................................................................16
Retinoblastoma Therapeutics - Products under Development by Companies ..........................................................................................................17
Retinoblastoma Therapeutics - Products under Investigation by Universities/Institutes ............................................................................................18
Companies Involved in Retinoblastoma Therapeutics Development ........................................................................................................................19
      RXi Pharmaceuticals Corporation......................................................................................................................................................................19
      Neotropix, Inc. ...................................................................................................................................................................................................19
Retinoblastoma - Therapeutics Assessment ............................................................................................................................................................20
      Assessment by Monotherapy Products .............................................................................................................................................................20
      Assessment by Combination Products ..............................................................................................................................................................21
      Assessment by Route of Administration ............................................................................................................................................................22
      Assessment by Molecule Type ..........................................................................................................................................................................24
Drug Profiles ...........................................................................................................................................................................................................26
      NTX-010 - Drug Profile ......................................................................................................................................................................................26
            Product Description ....................................................................................................................................................................................26
            Mechanism of Action...................................................................................................................................................................................26
            R&D Progress .............................................................................................................................................................................................26
      Amifostine Trihydrate - Drug Profile...................................................................................................................................................................28
            Product Description ....................................................................................................................................................................................28
            Mechanism of Action...................................................................................................................................................................................28
            R&D Progress .............................................................................................................................................................................................28
      Becatecarin - Drug Profile .................................................................................................................................................................................29
            Product Description ....................................................................................................................................................................................29
            Mechanism of Action...................................................................................................................................................................................29
            R&D Progress .............................................................................................................................................................................................29
      Torisel - Drug Profile .........................................................................................................................................................................................30
            Product Description ....................................................................................................................................................................................30
            Mechanism of Action...................................................................................................................................................................................30
            R&D Progress .............................................................................................................................................................................................30
      Melphalan - Drug Profile....................................................................................................................................................................................31
            Product Description ....................................................................................................................................................................................31


Retinoblastoma – Pipeline Review, H2 2011                                                                                                                     GMDHC1470IDB / Pub October 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                                                                                                                                Page(2)
Retinoblastoma – Pipeline Review, H2 2011


          Mechanism of Action...................................................................................................................................................................................31
          R&D Progress .............................................................................................................................................................................................31
     Filgrastim + Carboplatin + Cyclosporine + Etoposide + Vincristine - Drug Profile...............................................................................................32
          Product Description ....................................................................................................................................................................................32
          Mechanism of Action...................................................................................................................................................................................32
          R&D Progress .............................................................................................................................................................................................33
     Topotecan - Drug Profile ...................................................................................................................................................................................34
          Product Description ....................................................................................................................................................................................34
          Mechanism of Action...................................................................................................................................................................................34
          R&D Progress .............................................................................................................................................................................................34
     Vincristine + Carboplatin + Topotecan + Etoposide + Filgrastim + Radiation Therapy - Drug Profile..................................................................35
          Product Description ....................................................................................................................................................................................35
          Mechanism of Action...................................................................................................................................................................................35
          R&D Progress .............................................................................................................................................................................................36
     Vincristine + Carboplatin + Filgrastim + Radiation Therapy - Drug Profile ..........................................................................................................37
          Product Description ....................................................................................................................................................................................37
          Mechanism of Action...................................................................................................................................................................................37
          R&D Progress .............................................................................................................................................................................................37
     Filgrastim + Carboplatin + Etoposide + Stem Cell Transplantation - Drug Profile...............................................................................................39
          Product Description ..................................................................................................................................................................................
				
DOCUMENT INFO
Description: Retinoblastoma - Pipeline Review, H2 2011 Summary Global Markets Direct’s, 'Retinoblastoma - Pipeline Review, H2 2011', provides an overview of the Retinoblastoma therapeutic pipeline. This report provides information on the therapeutic development for Retinoblastoma, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Retinoblastoma. 'Retinoblastoma - Pipeline Review, H2 2011' is built using data and information sourced from Global Markets Direct’s proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct’s team. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - A snapshot of the global therapeutic scenario for Retinoblastoma. - A review of the Retinoblastoma products under development by companies and universities/research institutes based on information derived from company and industry-specific sources. - Coverage of products based on various stages of development ranging from discovery till registration stages. - A feature on pipeline projects on the basis of monotherapy and combined therapeutics. - Coverage of the Retinoblastoma pipeline on the basis of route of administration and molecule type. - Profiles of late-stage pipeline products featuring sections on product description, mechanism of action and research & development progress. - Key discontinued pipeline projects. - Latest news and deals relating to the products. Reasons to buy - Identify and understand important and diverse types of therapeutics under development for Retinoblastoma. - Identify emerging players with potentially strong product portfolio and design effective counter-strategies to gain c
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