Infertility - Pipeline Review, H2 2011

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					Infertility – Pipeline Review, H2 2011




                               Infertility - Pipeline Review, H2 2011
                                                                                          Reference Code: GMDHC1399IDB

                                                                                          Publication Date: September 2011




Infertility – Pipeline Review, H2 2011                                                                        GMDHC1399IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                                                 Page(1)
Infertility – Pipeline Review, H2 2011



Ta b le o f Co n te n ts
Table of Contents                                                                                                     2
List of Tables                                                                                                       10
List of Figures                                                                                                      12
Introduction                                                                                                         13
     Global Markets Direct Report Coverage                                                                           13
Infertility Overview                                                                                                 14
Therapeutics Development                                                                                             15
     An Overview of Pipeline Products for Infertility                                                                15
Infertility Therapeutics under Development by Companies                                                              17
Infertility Therapeutics under Investigation by Universities/Institutes                                              20
Late Stage Products                                                                                                  23
     Comparative Analysis                                                                                            23
Mid Clinical Stage Products                                                                                          24
     Comparative Analysis                                                                                            24
Early Clinical Stage Products                                                                                        25
     Comparative Analysis                                                                                            25
Discovery and Pre-Clinical Stage Products                                                                            26
     Comparative Analysis                                                                                            26
Infertility Therapeutics - Products under Development by Companies                                                   27
Infertility Therapeutics - Products under Investigation by Universities/Institutes                                   30
Companies Involved in Infertility Therapeutics Development                                                           32
     Abbott Laboratories                                                                                             32
     Vyteris, Inc.                                                                                                   32
     Watson Pharmaceuticals, Inc.                                                                                    33
     Merck & Co., Inc.                                                                                               33
     Euroscreen S.A.                                                                                                 34
     Takeda Pharmaceutical Company Limited                                                                           34
     Reliance Life Sciences Pvt. Ltd.                                                                                35
     Novartis AG                                                                                                     35
     ASKA Pharmaceutical Co., Ltd                                                                                    36
     Astellas Pharma Inc.                                                                                            36
     Dong-A Pharmaceutical Co., Ltd.                                                                                 37
     Hanmi Pharmaceutical Co Ltd                                                                                     37
     Kissei Pharmaceutical Co., Ltd.                                                                                 38
     Pfizer Inc.                                                                                                     38
     Teva Pharmaceutical Industries Limited                                                                          39
     Zydus Cadila Healthcare Limited                                                                                 39
     Pantec Biosolutions AG                                                                                          40
     Merck KGaA                                                                                                      40
     Access Pharmaceuticals, Inc.                                                                                    41
     Addex Pharmaceuticals                                                                                           41
     AEterna Zentaris Inc.                                                                                           42
     Soligenix, Inc.                                                                                                 42
     Repros Therapeutics Inc.                                                                                        43
     Protalix BioTherapeutics, Inc.                                                                                  44
     Glycotope GmbH                                                                                                  44
     Peptron, Inc.                                                                                                   45


Infertility – Pipeline Review, H2 2011                                                    GMDHC1399IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(2)
Infertility – Pipeline Review, H2 2011


     Meditrina Pharmaceuticals, Inc.                                                                                 45
     PregLem SA                                                                                                      46
     Ferring Pharmaceuticals, Inc.                                                                                   46
Infertility - Therapeutics Assessment                                                                                47
     Assessment by Monotherapy Products                                                                              47
     Assessment by Combination Products                                                                              48
     Assessment by Route of Administration                                                                           49
     Assessment by Molecule Type                                                                                     51
Drug Profiles                                                                                                        53
     AEZS-115 - Drug Profile                                                                                         53
          Product Description                                                                                        53
          Mechanism of Action                                                                                        53
          R&D Progress                                                                                               53
     TAK-385 - Drug Profile                                                                                          54
          Product Description                                                                                        54
          Mechanism of Action                                                                                        54
          R&D Progress                                                                                               54
     Hyperglycosylated FSH - Drug Profile                                                                            55
          Product Description                                                                                        55
          Mechanism of Action                                                                                        55
          R&D Progress                                                                                               55
     Anastrozole - Drug Profile                                                                                      56
          Product Description                                                                                        56
          Mechanism of Action                                                                                        56
          R&D Progress                                                                                               56
     Elagolix - Drug Profile                                                                                         57
          Product Description                                                                                        57
          Mechanism of Action                                                                                        57
          R&D Progress                                                                                               57
     ADX68692 - Drug Profile                                                                                         58
          Product Description                                                                                        58
          Mechanism of Action                                                                                        58
          R&D Progress                                                                                               58
     GnRH Antagonists - Drug Profile                                                                                 59
          Product Description                                                                                        59
          Mechanism of Action                                                                                        59
          R&D Progress                                                                                               59
     GnRH Patch - Drug Profile                                                                                       60
          Product Description                                                                                        60
          Mechanism of Action                                                                                        60
          R&D Progress                                                                                               60
     GT-GP 2.4 GEX - Drug Profile                                                                                    61
          Product Description                                                                                        61
          Mechanism of Action                                                                                        61
          R&D Progress                                                                                               61
     Asoprisnil - Drug Profile                                                                                       62
          Product Description                                                                                        62
          Mechanism of Action                                                                                        62




Infertility – Pipeline Review, H2 2011                                                    GMDHC1399IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(3)
Infertility – Pipeline Review, H2 2011


          R&D Progress                                                                                               62
     Emfilermin - Drug Profile                                                                                       64
          Product Description                                                                                        64
          Mechanism of Action                                                                                        64
          R&D Progress                                                                                               64
     Proellex - Drug Profile                                                                                         65
          Product Description                                                                                        65
          Mechanism of Action                                                                                        65
          R&D Progress                                                                                               65
     Recombinant Hormones For Ovulation Induction - Drug Profile                                                     67
          Product Description                                                                                        67
          Mechanism of Action                                                                                        67
          R&D Progress                                                                                               67
     LPM Leuprolide - Drug Profile                                                                                   68
          Product Description                                                                                        68
          Mechanism of Action                                                                                        68
          R&D Progress                                                                                               68
     PRX-111 - Drug Profile                                                                                          69
          Product Description                                                                                        69
          Mechanism of Action                                                                                        69
          R&D Progress                                                                                               69
     Fertility Hormone - Drug Profile                                                                                70
          Product Description                                                                                        70
          Mechanism of Action                                                                                        70
          R&D Progress                                                                                               70
     Drugs For Prostate Cancer & Endometriosis - Drug Profile                                                        71
          Product Description                                                                                        71
          Mechanism of Action                                                                                        71
          R&D Progress                                                                                               71
     JR-041 - Drug Profile                                                                                           72
          Product Description                                                                                        72
          Mechanism of Action                                                                                        72
          R&D Progress                                                                                               72
     JR-041 - Drug Profile                                                                                           73
          Product Description                                                                                        73
          Mechanism of Action                                                                                        73
          R&D Progress                                                                                               73
     ERB-041 - Drug Profile                                                                                          74
          Product Description                                                                                        74
          Mechanism of Action                                                                                        74
          R&D Progress                                                                                               74
     PGL1001 - Drug Profile                                                                                          75
          Product Description                                                                                        75
          Mechanism of Action                                                                                        75
          R&D Progress                                                                                               75
     PGL2001 - Drug Profile                                                                                          76
          Product Description                                                                                        76
          Mechanism of Action                                                                                        76




Infertility – Pipeline Review, H2 2011                                                    GMDHC1399IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(4)
Infertility – Pipeline Review, H2 2011


          R&D Progress                                                                                               76
     PGL3001 - Drug Profile                                                                                          77
          Product Description                                                                                        77
          Mechanism of Action                                                                                        77
          R&D Progress                                                                                               77
     ESN-364 - Drug Profile                                                                                          78
          Product Description                                                                                        78
          Mechanism of Action                                                                                        78
          R&D Progress                                                                                               78
     OCP - Drug Profile                                                                                              79
          Product Description                                                                                        79
          Mechanism of Action                                                                                        79
          R&D Progress                                                                                               79
     Elonva - Drug Profile                                                                                           80
          Product Description                                                                                        80
          Mechanism of Action                                                                                        80
          R&D Progress                                                                                               80
     DA-3803 - Drug Profile                                                                                          82
          Product Description                                                                                        82
          Mechanism of Action                                                                                        82
          R&D Progress                                                                                               82
     Metformin - Drug Profile                                                                                        83
          Product Description                                                                                        83
          Mechanism of Action                                                                                        83
          R&D Progress                                                                                               83
     Raloxifene - Drug Profile                                                                                       84
          Product Description                                                                                        84
          Mechanism of Action                                                                                        84
          R&D Progress                                                                                               84
     Human Chorionic Gonadotropin - Drug Profile                                                                     85
          Product Description                                                                                        85
          Mechanism of Action                                                                                        85
          R&D Progress                                                                                               85
     Clomiphene Citrate - Drug Profile                                                                               86
          Product Description                                                                                        86
          Mechanism of Action                                                                                        86
          R&D Progress                                                                                               86
     R-TPR-020 - Drug Profile                                                                                        87
          Product Description                                                                                        87
          Mechanism of Action                                                                                        87
          R&D Progress                                                                                               87
     Human Chorionic Gonadotropin + Clomiphene Citrate - Drug Profile                                                88
          Product Description                                                                                        88
          Mechanism of Action                                                                                        88
          R&D Progress                                                                                               88
     Leuprolide Acetate - Drug Profile                                                                               90
          Product Description                                                                                        90
          Mechanism of Action                                                                                        90




Infertility – Pipeline Review, H2 2011                                                    GMDHC1399IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(5)
Infertility – Pipeline Review, H2 2011


          R&D Progress                                                                                               90
     Microdose GnRh agonist - Drug Profile                                                                           91
          Product Description                                                                                        91
          Mechanism of Action                                                                                        91
          R&D Progress                                                                                               91
     Metformin - Drug Profile                                                                                        92
          Product Description                                                                                        92
          Mechanism of Action                                                                                        92
          R&D Progress                                                                                               92
     Metformin - Drug Profile                                                                                        93
          Product Description                                                                                        93
          Mechanism of Action                                                                                        93
          R&D Progress                                                                                               93
     MPI-676 - Drug Profile                                                                                          94
          Product Description                                                                                        94
          Mechanism of Action                                                                                        94
          R&D Progress                                                                                               94
     Metformin - Drug Profile                                                                                        95
          Product Description                                                                                        95
          Mechanism of Action                                                                                        95
          R&D Progress                                                                                               95
     Aldactone - Drug Profile                                                                                        96
          Product Description                                                                                        96
          Mechanism of Action                                                                                        96
          R&D Progress                                                                                               96
     Progesterone - Drug Profile                                                                                     97
          Product Description                                                                                        97
          Mechanism of Action                                                                                        97
          R&D Progress                                                                                               97
     Synthetic Gonadotropin Releasing Hormone - Drug Profile                                                         99
          Product Description                                                                                        99
          Mechanism of Action                                                                                        99
          R&D Progress                                                                                               99
     Yasmin - Drug Profile                                                                                          100
          Product Description                                                                                       100
          Mechanism of Action                                                                                       100
          R&D Progress                                                                                              100
     D-chiro-inositol - Drug Profile                                                                                101
          Product Description                                                                                       101
          Mechanism of Action                                                                                       101
          R&D Progress                                                                                              101
     Simvastatin - Drug Profile                                                                                     102
          Product Description                                                                                       102
          Mechanism of Action                                                                                       102
          R&D Progress                                                                                              102
     Dexamethasone + Recombinant hCG - Drug Profile                                                                 103
          Product Description                                                                                       103
          Mechanism of Action                                                                                       103




Infertility – Pipeline Review, H2 2011                                                    GMDHC1399IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(6)
Infertility – Pipeline Review, H2 2011


          R&D Progress                                                                                              103
     Metformin - Drug Profile                                                                                       105
          Product Description                                                                                       105
          Mechanism of Action                                                                                       105
          R&D Progress                                                                                              105
     BGS649 - Drug Profile                                                                                          106
          Product Description                                                                                       106
          Mechanism of Action                                                                                       106
          R&D Progress                                                                                              106
     GnRH agonist - Drug Profile                                                                                    107
          Product Description                                                                                       107
          Mechanism of Action                                                                                       107
          R&D Progress                                                                                              107
     Metformin - Drug Profile                                                                                       108
          Product Description                                                                                       108
          Mechanism of Action                                                                                       108
          R&D Progress                                                                                              108
     KLH-2109 - Drug Profile                                                                                        109
          Product Description                                                                                       109
          Mechanism of Action                                                                                       109
          R&D Progress                                                                                              109
     Letrozole - Drug Profile                                                                                       110
          Product Description                                                                                       110
          Mechanism of Action                                                                                       110
          R&D Progress                                                                                              110
     Neupogen - Drug Profile                                                                                        111
          Product Description                                                                                       111
          Mechanism of Action                                                                                       111
          R&D Progress                                                                                              111
     Recombinant Follicle Stimulating Hormone - Drug Profile                                                        113
          Product Description                                                                                       113
          Mechanism of Action                                                                                       113
          R&D Progress                                                                                              113
     Metformin + Clomiphene - Drug Profile                                                                          114
          Product Description                                                                                       114
          Mechanism of Action                                                                                       114
          R&D Progress                                                                                              114
     Tamoxifen + Clomiphene - Drug Profile                                                                          115
          Product Description                                                                                       115
          Mechanism of Action                                                                                       115
          R&D Progress                                                                                              115
     Prod 5 - Drug Profile                                                                                          116
          Product Description                                                                                       116
          Mechanism of Action                                                                                       116
          R&D Progress                                                                                              116
     Flutamide + Metformin - Drug Profile                                                                           117
          Product Description                                                                                       117
          Mechanism of Action                                                                                       117




Infertility – Pipeline Review, H2 2011                                                    GMDHC1399IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(7)
Infertility – Pipeline Review, H2 2011


          R&D Progress                                                                                              117
     Heparin - Drug Profile                                                                                         118
          Product Description                                                                                       118
          Mechanism of Action                                                                                       118
          R&D Progress                                                                                              118
     Clomiphene Citrate + Dexamethasone - Drug Profile                                                              119
          Product Description                                                                                       119
          Mechanism of Action                                                                                       119
          R&D Progress                                                                                              119
     Medroxyprogesterone - Drug Profile                                                                             120
          Product Description                                                                                       120
          Mechanism of Action                                                                                       120
          R&D Progress                                                                                              120
     Metformin - Drug Profile                                                                                       121
          Product Description                                                                                       121
          Mechanism of Action                                                                                       121
          R&D Progress                                                                                              121
     Aspirin - Drug Profile                                                                                         122
          Product Description                                                                                       122
          Mechanism of Action                                                                                       122
          R&D Progress                                                                                              122
     Oral Infertility Drugs - Drug Profile                                                                          123
          Product Description                                                                                       123
          Mechanism of Action               
				
DOCUMENT INFO
Description: Infertility - Pipeline Review, H2 2011 Summary Global Markets Direct’s, 'Infertility - Pipeline Review, H2 2011', provides an overview of the Infertility therapeutic pipeline. This report provides information on the therapeutic development for Infertility, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Infertility. 'Infertility - Pipeline Review, H2 2011' is built using data and information sourced from Global Markets Direct’s proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct’s team. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - A snapshot of the global therapeutic scenario for Infertility. - A review of the Infertility products under development by companies and universities/research institutes based on information derived from company and industry-specific sources. - Coverage of products based on various stages of development ranging from discovery till registration stages. - A feature on pipeline projects on the basis of monotherapy and combined therapeutics. - Coverage of the Infertility pipeline on the basis of route of administration and molecule type. - Profiles of late-stage pipeline products featuring sections on product description, mechanism of action and research & development progress. - Key discontinued pipeline projects. - Latest news and deals relating to the products. Reasons to buy - Identify and understand important and diverse types of therapeutics under development for Infertility. - Identify emerging players with potentially strong product portfolio and design effective counter-strategies to gain competitive advantage. - Plan
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Global Markets Direct is a leading provider of global business intelligence and market analysis. It publishes a range of high quality company and market reports created by its large research and analysis capability and drawing from its extensive unique databases of industry-specific information. Global Markets Direct has a broad range of coverage over key market segments. It has a global scope, covering a broad range of countries constituting more than 90% of global revenues in each of the industries it covers. With a large dedicated research and analysis capability, Global Markets Direct employs rigorous primary and secondary research techniques in developing unique data sets and research materials. Its status as an independent research company allows Analysts to conduct trade interviews with key industry players. Access to unique databases of in-house market information further strengthens research and analysis capabilities. Materials are reviewed shaped by an expert panel of leading industry figures and representatives from key players in the relevant industries