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Pneumonia - Pipeline Review, H2 2011

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Pneumonia - Pipeline Review, H2 2011 Summary Global Markets Direct’s, 'Pneumonia - Pipeline Review, H2 2011', provides an overview of the Pneumonia therapeutic pipeline. This report provides information on the therapeutic development for Pneumonia, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Pneumonia. 'Pneumonia - Pipeline Review, H2 2011' is built using data and information sourced from Global Markets Direct’s proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct’s team. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - A snapshot of the global therapeutic scenario for Pneumonia. - A review of the Pneumonia products under development by companies and universities/research institutes based on information derived from company and industry-specific sources. - Coverage of products based on various stages of development ranging from discovery till registration stages. - A feature on pipeline projects on the basis of monotherapy and combined therapeutics. - Coverage of the Pneumonia pipeline on the basis of route of administration and molecule type. - Profiles of late-stage pipeline products featuring sections on product description, mechanism of action and research & development progress. - Key discontinued pipeline projects. - Latest news and deals relating to the products. Reasons to buy - Identify and understand important and diverse types of therapeutics under development for Pneumonia. - Identify emerging players with potentially strong product portfolio and design effective counter-strategies to gain competitive advantage. - Plan mergers and acquisi

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									Pneumonia – Pipeline Review, H2 2011




                           Pneumonia - Pipeline Review, H2 2011
                                                                                          Reference Code: GMDHC1387IDB

                                                                                          Publication Date: September 2011




Pneumonia – Pipeline Review, H2 2011                                                                          GMDHC1387IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                                                 Page(1)
Pneumonia – Pipeline Review, H2 2011



Ta b le o f Co n te n ts
Table of Contents                                                                                                     2
List of Tables                                                                                                       10
List of Figures                                                                                                      12
Introduction                                                                                                         13
     Global Markets Direct Report Coverage                                                                           13
Pneumonia Overview                                                                                                   14
Therapeutics Development                                                                                             15
     An Overview of Pipeline Products for Pneumonia                                                                  15
Pneumonia Therapeutics under Development by Companies                                                                17
Pneumonia Therapeutics under Investigation by Universities/Institutes                                                20
Late Stage Products                                                                                                  23
     Comparative Analysis                                                                                            23
Mid Clinical Stage Products                                                                                          24
     Comparative Analysis                                                                                            24
Early Clinical Stage Products                                                                                        25
     Comparative Analysis                                                                                            25
Discovery and Pre-Clinical Stage Products                                                                            26
     Comparative Analysis                                                                                            26
Pneumonia Therapeutics - Products under Development by Companies                                                     27
Pneumonia Therapeutics - Products under Investigation by Universities/Institutes                                     30
Companies Involved in Pneumonia Therapeutics Development                                                             32
     Johnson & Johnson                                                                                               32
     Sequella, Inc.                                                                                                  32
     AlphaRx, Inc.                                                                                                   33
     AstraZeneca PLC                                                                                                 33
     GlaxoSmithKline plc                                                                                             34
     Nektar Therapeutics                                                                                             34
     Takeda Pharmaceutical Company Limited                                                                           35
     Nanotherapeutics, Inc.                                                                                          35
     Rib-X Pharmaceuticals, Inc.                                                                                     36
     Warner Chilcott Limited                                                                                         36
     Optimer Pharmaceuticals, Inc.                                                                                   37
     Paratek Pharmaceuticals, Inc.                                                                                   37
     Bayer AG                                                                                                        38
     Intercell AG                                                                                                    39
     Basilea Pharmaceutica Ltd.                                                                                      40
     Oragenics, Inc.                                                                                                 40
     Pacgen Biopharmaceuticals Corporation                                                                           41
     Advanced Life Sciences Holdings, Inc.                                                                           41
     Lipoxen PLC                                                                                                     42
     Dongwha Pharm Co., Ltd.                                                                                         42
     Synairgen plc                                                                                                   43
     Eurocine Vaccines AB                                                                                            43
     MerLion Pharmaceuticals Pte Ltd                                                                                 44
     Mucosis B.V.                                                                                                    44
     Evolva SA                                                                                                       45
     Aridis Pharmaceuticals LLC                                                                                      45


Pneumonia – Pipeline Review, H2 2011                                                      GMDHC1387IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(2)
Pneumonia – Pipeline Review, H2 2011


     Pulmatrix, Inc.                                                                                                 46
     Kenta Biotech Ltd.                                                                                              46
     Nabriva Therapeutics AG                                                                                         47
     Enanta Pharmaceuticals, Inc.                                                                                    47
     KaloBios Pharmaceuticals, Inc.                                                                                  48
     Trius Therapeutics, Inc.                                                                                        48
     Tetraphase Pharmaceuticals Inc.                                                                                 49
     Endacea, Inc.                                                                                                   49
Pneumonia - Therapeutics Assessment                                                                                  50
     Assessment by Monotherapy Products                                                                              50
     Assessment by Combination Products                                                                              51
     Assessment by Route of Administration                                                                           52
     Assessment by Molecule Type                                                                                     55
Drug Profiles                                                                                                        58
     BAY41-6551 - Drug Profile                                                                                       58
          Product Description                                                                                        58
          Mechanism of Action                                                                                        58
          R&D Progress                                                                                               58
     MEDI-534 - Drug Profile                                                                                         60
          Product Description                                                                                        60
          Mechanism of Action                                                                                        60
          R&D Progress                                                                                               60
     AR-709 - Drug Profile                                                                                           61
          Product Description                                                                                        61
          Mechanism of Action                                                                                        61
          R&D Progress                                                                                               61
     Cipro NDS - Drug Profile                                                                                        62
          Product Description                                                                                        62
          Mechanism of Action                                                                                        62
          R&D Progress                                                                                               62
     Vansolin - Drug Profile                                                                                         63
          Product Description                                                                                        63
          Mechanism of Action                                                                                        63
          R&D Progress                                                                                               63
     NKTR-063 - Drug Profile                                                                                         64
          Product Description                                                                                        64
          Mechanism of Action                                                                                        64
          R&D Progress                                                                                               64
     Restanza - Drug Profile                                                                                         65
          Product Description                                                                                        65
          Mechanism of Action                                                                                        65
          R&D Progress                                                                                               65
     Teflaro - Drug Profile                                                                                          67
          Product Description                                                                                        67
          Mechanism of Action                                                                                        67
          R&D Progress                                                                                               67
     NanoGENT - Drug Profile                                                                                         69
          Product Description                                                                                        69




Pneumonia – Pipeline Review, H2 2011                                                      GMDHC1387IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(3)
Pneumonia – Pipeline Review, H2 2011


          Mechanism of Action                                                                                        69
          R&D Progress                                                                                               69
     Omadacycline - Drug Profile                                                                                     70
          Product Description                                                                                        70
          Mechanism of Action                                                                                        70
          R&D Progress                                                                                               70
     MX-2401 - Drug Profile                                                                                          72
          Product Description                                                                                        72
          Mechanism of Action                                                                                        72
          R&D Progress                                                                                               72
     MU1140 - Drug Profile                                                                                           73
          Product Description                                                                                        73
          Mechanism of Action                                                                                        73
          R&D Progress                                                                                               73
     BC-3205 - Drug Profile                                                                                          74
          Product Description                                                                                        74
          Mechanism of Action                                                                                        74
          R&D Progress                                                                                               74
     KBPA101 - Drug Profile                                                                                          75
          Product Description                                                                                        75
          Mechanism of Action                                                                                        75
          R&D Progress                                                                                               75
     RX-1741 - Drug Profile                                                                                          76
          Product Description                                                                                        76
          Mechanism of Action                                                                                        76
          R&D Progress                                                                                               76
     PAC-525 - Drug Profile                                                                                          78
          Product Description                                                                                        78
          Mechanism of Action                                                                                        78
          R&D Progress                                                                                               78
     PAC-G31P - Drug Profile                                                                                         79
          Product Description                                                                                        79
          Mechanism of Action                                                                                        79
          R&D Progress                                                                                               79
     Friulimicin - Drug Profile                                                                                      80
          Product Description                                                                                        80
          Mechanism of Action                                                                                        80
          R&D Progress                                                                                               80
     KB001 - Drug Profile                                                                                            81
          Product Description                                                                                        81
          Mechanism of Action                                                                                        81
          R&D Progress                                                                                               81
     KB001 - Drug Profile                                                                                            83
          Product Description                                                                                        83
          Mechanism of Action                                                                                        83
          R&D Progress                                                                                               83
     SQ641 - Drug Profile                                                                                            85
          Product Description                                                                                        85




Pneumonia – Pipeline Review, H2 2011                                                      GMDHC1387IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(4)
Pneumonia – Pipeline Review, H2 2011


          Mechanism of Action                                                                                        85
          R&D Progress                                                                                               85
     LipoNeu - Drug Profile                                                                                          86
          Product Description                                                                                        86
          Mechanism of Action                                                                                        86
          R&D Progress                                                                                               86
     L-97-1 - Drug Profile                                                                                           87
          Product Description                                                                                        87
          Mechanism of Action                                                                                        87
          R&D Progress                                                                                               87
     OP-1068 - Drug Profile                                                                                          89
          Product Description                                                                                        89
          Mechanism of Action                                                                                        89
          R&D Progress                                                                                               89
     NXL103 - Drug Profile                                                                                           91
          Product Description                                                                                        91
          Mechanism of Action                                                                                        91
          R&D Progress                                                                                               91
     Tedizolid Phosphate - Drug Profile                                                                              92
          Product Description                                                                                        92
          Mechanism of Action                                                                                        92
          R&D Progress                                                                                               92
     DW-224 - Drug Profile                                                                                           93
          Product Description                                                                                        93
          Mechanism of Action                                                                                        93
          R&D Progress                                                                                               93
     EDP-420 - Drug Profile                                                                                          95
          Product Description                                                                                        95
          Mechanism of Action                                                                                        95
          R&D Progress                                                                                               95
     IC43 - Drug Profile                                                                                             96
          Product Description                                                                                        96
          Mechanism of Action                                                                                        96
          R&D Progress                                                                                               96
     Pneumococcal Vaccines - Drug Profile                                                                            97
          Product Description                                                                                        97
          Mechanism of Action                                                                                        97
          R&D Progress                                                                                               97
     Nemonoxacin - Drug Profile                                                                                      98
          Product Description                                                                                        98
          Mechanism of Action                                                                                        98
          R&D Progress                                                                                               98
     Nemonoxacin - Drug Profile                                                                                     100
          Product Description                                                                                       100
          Mechanism of Action                                                                                       100
          R&D Progress                                                                                              100
     Aerucin - Drug Profile                                                                                         102
          Product Description                                                                                       102




Pneumonia – Pipeline Review, H2 2011                                                      GMDHC1387IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(5)
Pneumonia – Pipeline Review, H2 2011


          Mechanism of Action                                                                                       102
          R&D Progress                                                                                              102
     Mimopath Based Pneumococcal Vaccine - Drug Profile                                                             103
          Product Description                                                                                       103
          Mechanism of Action                                                                                       103
          R&D Progress                                                                                              103
     Chlorhexidine - Drug Profile                                                                                   104
          Product Description                                                                                       104
          Mechanism of Action                                                                                       104
          R&D Progress                                                                                              104
     Moxifloxacin - Drug Profile                                                                                    105
          Product Description                                                                                       105
          Mechanism of Action                                                                                       105
          R&D Progress                                                                                              105
     Enbrel - Drug Profile                                                                                          106
          Product Description                                                                                       106
          Mechanism of Action                                                                                       106
          R&D Progress                                                                                              106
     Amoxicillin - Drug Profile                                                                                     107
          Product Description                                                                                       107
          Mechanism of Action                                                                                       107
          R&D Progress                                                                                              107
     Trimetrexate Glucuronate + Leucovorin Calcium - Drug Profile                                                   108
          Product Description                                                                                       108
          Mechanism of Action                                                                                       108
          R&D Progress                                                                                              108
     Chloramphenicol - Drug Profile                                                                                 109
          Product Description                                                                                       109
          Mechanism of Action                                                                                       109
          R&D Progress                                                                                              109
     Chlorhexidine - Drug Profile                                                                                   111
          Product Description                                                                                       111
          Mechanism of Action                                                                                       111
          R&D Progress                                                                                              111
     Prevnar - Drug Profile                                                                                         112
          Product Description                                                                                       112
          Mechanism of Action                                                                                       112
          R&D Progress                                                                                              112
     GSK1024850A - Drug Profile                                                                                     113
          Product Description                                                                                       113
          Mechanism of Action                                                                                       113
          R&D Progress                                                                                              113
     Interferon Beta Programme - Drug Profile                                                                       114
          Product Description                                                                                       114
          Mechanism of Action                                                                                       114
          R&D Progress                                                                                              114
     Cotrimoxazole - Drug Profile                                                                                   116
          Product Description                                                                                       116




Pneumonia – Pipeline Review, H2 2011                                                      GMDHC1387IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(6)
Pneumonia – Pipeline Review, H2 2011


          Mechanism of Action                                                                                       116
          R&D Progress                                                                                              116
     Enbrel + Corticosteroids - Drug Profile                                                                        117
          Product Description                                                                                       117
          Mechanism of Action                                                                                       117
          R&D Progress                                                                                              117
     Urokinase - Drug Profile                                                                                       119
          Product Description                                                                                       119
          Mechanism of Action                                                                                       119
          R&D Progress                                                                                              119
     Prednisone - Drug Profile                                                                                      120
          Product Description                                                                                       120
          Mechanism of Action                                                                                       120
          R&D Progress                                                                                              120
     Ulinastatin - Drug Profile                                                                                     121
          Product Description                                                                                       121
          Mechanism of Action                                                                                       121
          R&D Progress                                                                                              121
     GSK2189242A - Drug Profile                                                                                     122
          Product Description                                                                                       122
          Mechanism of Action                                                                                       122
          R&D Progress                                                                                              122
     Doribax - Drug Profile                                                                                         123
          Product Description                                                                                       123
          Mechanism of Action                                                                                       123
          R&D Progress                                                                                              123
     JNJ-Q2 - Drug Profile                                                                                          125
          Product Description                                                                                       125
          Mechanism of Action                                                                                       125
          R&D Progress                                                                                              125
     Nasal Pneumococcal Vaccine - Drug Profile                                                                      127
          Product Description                                                                                       127
          Mechanism of Action                                                                                       127
          R&D Progress                                                                                              127
     Ceftobiprole Medocaril - Drug Profile                                                                          128
          Product Description                                                                                       128
          Mechanism of Action                                                                                       128
          R&D Progress                                                                                              128
     AZD9742 - Drug Profile                                                                                         130
          Product Description                                                                                       130
          Mechanism of Action                                                                                       130
          R&D Progress                                                                                              130
     PCV7 + Pneumovax 23 - Drug Profile                                                                             131
          Product Description                                                                                       131
          Mechanism of Action                                                                                       131
          R&D Progress                                                                                              131
     Pentamidine Isethionate - Drug Profile                                                                         132
          Product Description                                                                                       132




Pneumonia – Pipeline Review, H2 2011                                                      GMDHC1387IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(7)
Pneumonia – Pipeline Review, H2 2011


          Mechanism of Action                                                                                       132
          R&D Progress                                                                                              132
     Panaecin - Drug Profile                                                                                        133
          Product Description                                                                                       133
          Mechanism of Action                                                                                       133
          R&D Progress                                                                                              133
     Prevenar - Drug Profile                                                                                        134
          Product Description                                                                                       134
          Mechanism of Action                                                                                       134
          R&D Progress                                                                                              134
     9 Valent Pneumococcal Conjugate Vaccine - Drug Profile                                                         135
          Product Description                                                                                       135
          Mechanism of Action                                                                                       135
          R&D Progress                                                                                              135
     CAZ104 - Drug Profile                                                                                          136
          Product Description                                                                                       136
          Mechanism of Action                                                                                       136
          R&D Progress                                                                                              136
     Hydrocortisone + Fludrocortisone - Drug Profile                                                                137
          Product Description                                                                                       137
          Mechanism of Action                                                                                       137
          R&D Progress                                                                                              137
     Oseltamivir - Drug Profile                                                                                     138
          Product Description                                                                                       138
          Mechanism of Action                                                                                       138
          R&D Progress                                                                                              138
     Simvastatin - Drug Profile                                                                                     139
          Product Description                                                                                       139
          Mechanism of Action                                                                                       139
          R&D Progress                                                                                              139
     Zinc - Drug Profile                                                                                            140
          Product Description                                                       
								
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