Insomnia Pipeline Review H2 2011 by GlobalMarketsDirect

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									Insomnia – Pipeline Review, H2 2011




                               Insomnia - Pipeline Review, H2 2011
                                                                                          Reference Code: GMDHC1343IDB

                                                                                          Publication Date: September 2011




Insomnia – Pipeline Review, H2 2011                                                                           GMDHC1343IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                                                 Page(1)
Insomnia – Pipeline Review, H2 2011



Ta b le o f Co n te n ts
Table of Contents                                                                                                     2
List of Tables                                                                                                        6
List of Figures                                                                                                       7
Introduction                                                                                                          8
     Global Markets Direct Report Coverage                                                                            8
Insomnia Overview                                                                                                     9
Therapeutics Development                                                                                             10
     An Overview of Pipeline Products for Insomnia                                                                   10
Insomnia Therapeutics under Development by Companies                                                                 12
Insomnia Therapeutics under Investigation by Universities/Institutes                                                 14
Late Stage Products                                                                                                  15
     Comparative Analysis                                                                                            15
Mid Clinical Stage Products                                                                                          16
     Comparative Analysis                                                                                            16
Early Clinical Stage Products                                                                                        17
     Comparative Analysis                                                                                            17
Discovery and Pre-Clinical Stage Products                                                                            18
     Comparative Analysis                                                                                            18
Insomnia Therapeutics - Products under Development by Companies                                                      19
Insomnia Therapeutics - Products under Investigation by Universities/Institutes                                      21
Companies Involved in Insomnia Therapeutics Development                                                              22
     Eli Lilly and Company                                                                                           22
     GlaxoSmithKline plc                                                                                             22
     Merck & Co., Inc.                                                                                               23
     Dainippon Sumitomo Pharma Co., Ltd.                                                                             23
     Takeda Pharmaceutical Company Limited                                                                           24
     Alexza Pharmaceuticals, Inc.                                                                                    24
     Eisai Co., Ltd.                                                                                                 25
     Evotec Aktiengesellschaft                                                                                       25
     IntelGenx Technologies Corp.                                                                                    26
     Arena Pharmaceuticals, Inc.                                                                                     26
     Jazz Pharmaceuticals, Inc.                                                                                      27
     Transcept Pharmaceuticals, Inc.                                                                                 27
     Neurim Pharmaceuticals (1991) Ltd.                                                                              28
     Abeille Pharmaceuticals, Inc.                                                                                   28
     Intec Pharma ltd.                                                                                               29
     Ferrer Internacional S.A.                                                                                       29
     Rottapharm SpA                                                                                                  30
     Somnus Therapeutics, Inc.                                                                                       30
     Intra-Cellular Therapies, Inc.                                                                                  31
     Heptares Therapeutics Ltd.                                                                                      31
     Eurofarma                                                                                                       32
Insomnia - Therapeutics Assessment                                                                                   33
     Assessment by Monotherapy Products                                                                              33
     Assessment by Combination Products                                                                              34
     Assessment by Route of Administration                                                                           35
     Assessment by Molecule Type                                                                                     37


Insomnia – Pipeline Review, H2 2011                                                       GMDHC1343IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(2)
Insomnia – Pipeline Review, H2 2011


Drug Profiles                                                                                                        39
     JZP-6 - Drug Profile                                                                                            39
          Product Description                                                                                        39
          Mechanism of Action                                                                                        39
          R&D Progress                                                                                               39
     LY2624803 - Drug Profile                                                                                        41
          Product Description                                                                                        41
          Mechanism of Action                                                                                        41
          R&D Progress                                                                                               41
     MK-4305 - Drug Profile                                                                                          42
          Product Description                                                                                        42
          Mechanism of Action                                                                                        42
          R&D Progress                                                                                               42
     AZ-007 - Drug Profile                                                                                           44
          Product Description                                                                                        44
          Mechanism of Action                                                                                        44
          R&D Progress                                                                                               44
     SEP-0227018 - Drug Profile                                                                                      45
          Product Description                                                                                        45
          Mechanism of Action                                                                                        45
          R&D Progress                                                                                               45
     SB-649868 - Drug Profile                                                                                        46
          Product Description                                                                                        46
          Mechanism of Action                                                                                        46
          R&D Progress                                                                                               46
     Neu-P11 - Drug Profile                                                                                          47
          Product Description                                                                                        47
          Mechanism of Action                                                                                        47
          R&D Progress                                                                                               47
     Intermezzo - Drug Profile                                                                                       48
          Product Description                                                                                        48
          Mechanism of Action                                                                                        48
          R&D Progress                                                                                               48
     AB-1003 - Drug Profile                                                                                          50
          Product Description                                                                                        50
          Mechanism of Action                                                                                        50
          R&D Progress                                                                                               50
     SKP-1041 - Drug Profile                                                                                         51
          Product Description                                                                                        51
          Mechanism of Action                                                                                        51
          R&D Progress                                                                                               51
     Orexin 2 - Drug Profile                                                                                         52
          Product Description                                                                                        52
          Mechanism of Action                                                                                        52
          R&D Progress                                                                                               52
     ITI-007 - Drug Profile                                                                                          53
          Product Description                                                                                        53
          Mechanism of Action                                                                                        53




Insomnia – Pipeline Review, H2 2011                                                       GMDHC1343IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(3)
Insomnia – Pipeline Review, H2 2011


          R&D Progress                                                                                               53
     CR 5542 Series - Drug Profile                                                                                   54
          Product Description                                                                                        54
          Mechanism of Action                                                                                        54
          R&D Progress                                                                                               54
     Vestipitant - Drug Profile                                                                                      55
          Product Description                                                                                        55
          Mechanism of Action                                                                                        55
          R&D Progress                                                                                               55
     GF-015535-00 - Drug Profile                                                                                     56
          Product Description                                                                                        56
          Mechanism of Action                                                                                        56
          R&D Progress                                                                                               56
     Melatonin - Drug Profile                                                                                        57
          Product Description                                                                                        57
          Mechanism of Action                                                                                        57
          R&D Progress                                                                                               57
     Escitalopram + Sertraline + Desvenlafaxine - Drug Profile                                                       58
          Product Description                                                                                        58
          Mechanism of Action                                                                                        58
          R&D Progress                                                                                               58
     Eszopiclone - Drug Profile                                                                                      59
          Product Description                                                                                        59
          Mechanism of Action                                                                                        59
          R&D Progress                                                                                               59
     Lunesta + Venlafaxine - Drug Profile                                                                            60
          Product Description                                                                                        60
          Mechanism of Action                                                                                        60
          R&D Progress                                                                                               60
     Armodafinil - Drug Profile                                                                                      61
          Product Description                                                                                        61
          Mechanism of Action                                                                                        61
          R&D Progress                                                                                               61
     Ramelteon + Doxepin - Drug Profile                                                                              62
          Product Description                                                                                        62
          Mechanism of Action                                                                                        62
          R&D Progress                                                                                               62
     Rozerem + Gabapentin - Drug Profile                                                                             64
          Product Description                                                                                        64
          Mechanism of Action                                                                                        64
          R&D Progress                                                                                               64
     APD125 - Drug Profile                                                                                           65
          Product Description                                                                                        65
          Mechanism of Action                                                                                        65
          R&D Progress                                                                                               65
     Melatonin - Drug Profile                                                                                        66
          Product Description                                                                                        66
          Mechanism of Action                                                                                        66




Insomnia – Pipeline Review, H2 2011                                                       GMDHC1343IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(4)
Insomnia – Pipeline Review, H2 2011


          R&D Progress                                                                                                                66
     Trazodone - Drug Profile                                                                                                         67
          Product Description                                                                                                         67
          Mechanism of Action                                                                                                         67
          R&D Progress                                                                                                                67
     MK-6096 - Drug Profile                                                                                                           68
          Product Description                                                                                                         68
          Mechanism of Action                                                                                                         68
          R&D Progress                                                                                                                68
     Lunesta - Drug Profile                                                                                                           69
          Product Description                                                                                                         69
          Mechanism of Action                                                                                                         69
          R&D Progress                                                                                                                69
     Zaleplon GR - Drug Profile                                                                                                       70
          Product Description                                                                                                         70
          Mechanism of Action                                                                                                         70
          R&D Progress                                                                                                                70
     MK-3697 - Drug Profile                                                                                                           71
          Product Description                                                                                                         71
          Mechanism of Action                                                                                                         71
          R&D Progress                                                                                                                71
     SEP-190 - Drug Profile                                                                                                           72
          Product Description                                                                                                         72
          Mechanism of Action                                                                                                         72
          R&D Progress                                                                                                                72
     INT0020 - Drug Profile                               
								
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