Acute Ischemic Stroke Pipeline Review H2 2011 by GlobalMarketsDirect

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									Acute Ischemic Stroke – Pipeline Review, H2 2011




        Acute Ischemic Stroke - Pipeline Review, H2 2011
                                                                                          Reference Code: GMDHC1335IDB

                                                                                          Publication Date: September 2011




Acute Ischemic Stroke – Pipeline Review, H2 2011                                                              GMDHC1335IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                                                 Page(1)
Acute Ischemic Stroke – Pipeline Review, H2 2011



Ta b le o f Co n te n ts
Table of Contents                                                                                                          2
List of Tables                                                                                                             7
List of Figures                                                                                                            9
Introduction                                                                                                              10
     Global Markets Direct Report Coverage                                                                                10
Acute Ischemic Stroke Overview                                                                                            11
Therapeutics Development                                                                                                  12
     An Overview of Pipeline Products for Acute Ischemic Stroke                                                           12
Acute Ischemic Stroke Therapeutics under Development by Companies                                                         14
Acute Ischemic Stroke Therapeutics under Investigation by Universities/Institutes                                         16
Late Stage Products                                                                                                       19
     Comparative Analysis                                                                                                 19
Mid Clinical Stage Products                                                                                               20
     Comparative Analysis                                                                                                 20
Early Clinical Stage Products                                                                                             21
     Comparative Analysis                                                                                                 21
Discovery and Pre-Clinical Stage Products                                                                                 22
     Comparative Analysis                                                                                                 22
Acute Ischemic Stroke Therapeutics - Products under Development by Companies                                              23
Acute Ischemic Stroke Therapeutics - Products under Investigation by Universities/Institutes                              25
Companies Involved in Acute Ischemic Stroke Therapeutics Development                                                      27
     Sanofi-Aventis                                                                                                       27
     Eli Lilly and Company                                                                                                27
     Aldagen, Inc.                                                                                                        28
     Henry Ford Health System                                                                                             28
     H Lundbeck A/S                                                                                                       29
     Mitsubishi Tanabe Pharma Corporation                                                                                 29
     Pfizer Inc.                                                                                                          30
     Celgene Corporation                                                                                                  30
     Vernalis plc                                                                                                         31
     RegeneRx Biopharmaceuticals, Inc.                                                                                    31
     ReNeuron Group plc                                                                                                   32
     SYGNIS Pharma AG                                                                                                     32
     Torrent Pharmaceuticals Limited                                                                                      33
     ThromboGenics NV                                                                                                     33
     D-Pharm Ltd.                                                                                                         34
     BioMAS Ltd.                                                                                                          34
     Ferrer Internacional S.A.                                                                                            35
     Stemedica Cell Technologies, Inc.                                                                                    35
     M's Science Corporation                                                                                              36
     Thrombotech Technologies, Ltd.                                                                                       36
     Gaia BioPharma Limited                                                                                               36
Acute Ischemic Stroke - Therapeutics Assessment                                                                           37
     Assessment by Monotherapy Products                                                                                   37
     Assessment by Combination Products                                                                                   38
     Assessment by Route of Administration                                                                                39
     Assessment by Molecule Type                                                                                          41


Acute Ischemic Stroke – Pipeline Review, H2 2011                                               GMDHC1335IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                                   Page(2)
Acute Ischemic Stroke – Pipeline Review, H2 2011


Drug Profiles                                                                                                        43
     Desmoteplase - Drug Profile                                                                                     43
          Product Description                                                                                        43
          Mechanism of Action                                                                                        43
          R&D Progress                                                                                               43
     MCI-186 - Drug Profile                                                                                          45
          Product Description                                                                                        45
          Mechanism of Action                                                                                        45
          R&D Progress                                                                                               45
     ILS-920 - Drug Profile                                                                                          46
          Product Description                                                                                        46
          Mechanism of Action                                                                                        46
          R&D Progress                                                                                               46
     PDA001 - Drug Profile                                                                                           47
          Product Description                                                                                        47
          Mechanism of Action                                                                                        47
          R&D Progress                                                                                               47
     MP-124 - Drug Profile                                                                                           48
          Product Description                                                                                        48
          Mechanism of Action                                                                                        48
          R&D Progress                                                                                               48
     Citicoline - Drug Profile                                                                                       49
          Product Description                                                                                        49
          Mechanism of Action                                                                                        49
          R&D Progress                                                                                               49
     Ocriplasmin - Drug Profile                                                                                      50
          Product Description                                                                                        50
          Mechanism of Action                                                                                        50
          R&D Progress                                                                                               50
     DP-b99 - Drug Profile                                                                                           52
          Product Description                                                                                        52
          Mechanism of Action                                                                                        52
          R&D Progress                                                                                               52
     GAI-122 - Drug Profile                                                                                          53
          Product Description                                                                                        53
          Mechanism of Action                                                                                        53
          R&D Progress                                                                                               53
     AX200 - Drug Profile                                                                                            54
          Product Description                                                                                        54
          Mechanism of Action                                                                                        54
          R&D Progress                                                                                               54
     RGN-352 - Drug Profile                                                                                          55
          Product Description                                                                                        55
          Mechanism of Action                                                                                        55
          R&D Progress                                                                                               55
     Radicut - Drug Profile                                                                                          56
          Product Description                                                                                        56
          Mechanism of Action                                                                                        56




Acute Ischemic Stroke – Pipeline Review, H2 2011                                          GMDHC1335IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(3)
Acute Ischemic Stroke – Pipeline Review, H2 2011


          R&D Progress                                                                                               56
     SA4503 - Drug Profile                                                                                           57
          Product Description                                                                                        57
          Mechanism of Action                                                                                        57
          R&D Progress                                                                                               57
     V10153 - Drug Profile                                                                                           58
          Product Description                                                                                        58
          Mechanism of Action                                                                                        58
          R&D Progress                                                                                               58
     Minocycline - Drug Profile                                                                                      59
          Product Description                                                                                        59
          Mechanism of Action                                                                                        59
          R&D Progress                                                                                               59
     Activase + Integrilin - Drug Profile                                                                            60
          Product Description                                                                                        60
          Mechanism of Action                                                                                        60
          R&D Progress                                                                                               60
     Aricept - Drug Profile                                                                                          61
          Product Description                                                                                        61
          Mechanism of Action                                                                                        61
          R&D Progress                                                                                               61
     AS101 - Drug Profile                                                                                            62
          Product Description                                                                                        62
          Mechanism of Action                                                                                        62
          R&D Progress                                                                                               62
     NA-1 - Drug Profile                                                                                             64
          Product Description                                                                                        64
          Mechanism of Action                                                                                        64
          R&D Progress                                                                                               64
     Effient - Drug Profile                                                                                          65
          Product Description                                                                                        65
          Mechanism of Action                                                                                        65
          R&D Progress                                                                                               65
     Deferoxamine - Drug Profile                                                                                     67
          Product Description                                                                                        67
          Mechanism of Action                                                                                        67
          R&D Progress                                                                                               67
     Integrillin + Aspirin + Innohep - Drug Profile                                                                  68
          Product Description                                                                                        68
          Mechanism of Action                                                                                        68
          R&D Progress                                                                                               68
     Recombinant Tissue Plasminogen Activator - Drug Profile                                                         69
          Product Description                                                                                        69
          Mechanism of Action                                                                                        69
          R&D Progress                                                                                               69
     Argatroban + Alteplase - Drug Profile                                                                           70
          Product Description                                                                                        70
          Mechanism of Action                                                                                        70




Acute Ischemic Stroke – Pipeline Review, H2 2011                                          GMDHC1335IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(4)
Acute Ischemic Stroke – Pipeline Review, H2 2011


          R&D Progress                                                                                               70
     Human Serum Albumin Infusion - Drug Profile                                                                     71
          Product Description                                                                                        71
          Mechanism of Action                                                                                        71
          R&D Progress                                                                                               71
     Aricept - Drug Profile                                                                                          72
          Product Description                                                                                        72
          Mechanism of Action                                                                                        72
          R&D Progress                                                                                               72
     Clopidogrel - Drug Profile                                                                                      73
          Product Description                                                                                        73
          Mechanism of Action                                                                                        73
          R&D Progress                                                                                               73
     Xiaoshuanchangrong - Drug Profile                                                                               74
          Product Description                                                                                        74
          Mechanism of Action                                                                                        74
          R&D Progress                                                                                               74
     Dapsone - Drug Profile                                                                                          75
          Product Description                                                                                        75
          Mechanism of Action                                                                                        75
          R&D Progress                                                                                               75
     Propranolol - Drug Profile                                                                                      76
          Product Description                                                                                        76
          Mechanism of Action                                                                                        76
          R&D Progress                                                                                               76
     Insulin - Drug Profile                                                                                          77
          Product Description                                                                                        77
          Mechanism of Action                                                                                        77
          R&D Progress                                                                                               77
     Magnesium Sulfate - Drug Profile                                                                                78
          Product Description                                                                                        78
          Mechanism of Action                                                                                        78
          R&D Progress                                                                                               78
     Filgrastim - Drug Profile                                                                                       79
          Product Description                                                                                        79
          Mechanism of Action                                                                                        79
          R&D Progress                                                                                               79
     GM602 - Drug Profile                                                                                            80
          Product Description                                                                                        80
          Mechanism of Action                                                                                        80
          R&D Progress                                                                                               80
     SAR 104772 - Drug Profile                                                                                       81
          Product Description                                                                                        81
          Mechanism of Action                                                                                        81
          R&D Progress                                                                                               81
     CTX0E03 - Drug Profile                                                                                          82
          Product Description                                                                                        82
          Mechanism of Action                                                                                        82




Acute Ischemic Stroke – Pipeline Review, H2 2011                                          GMDHC1335IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(5)
Acute Ischemic Stroke – Pipeline Review, H2 2011


          R&D Progress                                                                                               82
     ALD-401 - Drug Profile                                                                                          83
          Product Description                                                                                        83
          Mechanism of Action                                                                                        83
          R&D Progress                                                                                               83
     Avonex - Drug Profile                                                                                           84
          Product Description                                                                                        84
          Mechanism of Action                                                                                        84
          R&D Progress                                                                                               84
     WE-Thrombin - Drug Profile                                                                                      85
          Product Description                                                                                        85
          Mechanism of Action                                                                                        85
          R&D Progress                                                                                               85
     Warfarin - Drug Profile                                                                                         86
          Product Description                                                                                        86
          Mechanism of Action                                                                                        86
          R&D Progress                                                                                               86
     Aspirin - Drug Profile                                                                                          87
          Product Description                                                                                        87
          Mechanism of Action                                                                                        87
          R&D Progress                                                                                               87
     Noscapine - Drug Profile                                                                                        88
          Product Description                                                                                        88
          Mechanism of Action                                                                                        88
          R&D Progress                                                                                               88
     Activase - Drug Profile                                                                                         89
          Product Description                                                                                        89
          Mechanism of Action                                                                                        89
          R&D Progress                                                                                               89
     Allogeneic Mesenchymal Bone Marrow Cells - Drug Profile                                                         90
          Product Description                                                                                        90
          Mechanism of Action                                                                                        90
          R&D Progress                                                                                               90
     Thymosin beta 4 - Drug Profile                                                                                  91
          Product Description                                                                                        91
          Mechanism of Action                                                                                        91
          R&D Progress                                                                                               91
     THR-18 + tPA - Drug Profile                                                                                     92
          Product Description                                                                                        92
          Mechanism of Action                                                                                        92
          R&D Progress                                                                                               92
     TRC-6XXX - Drug Profile                                                                                         93
          Product Description                                                                                        93
          Mechanism of Action                                                                                        93
          R&D Progress                                                                                               93
Acute Ischemic Stroke Therapeutics – Drug Profile Updates                                                            94
Acute Ischemic Stroke Therapeutics - Discontinued Products                                                          100
     Acute Ischemic Stroke - Featured News                                                                          101




Acute Ischemic Stroke – Pipeline Review, H2 2011                                          GMDHC1335IDB / Pub September 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(6)
Acute Ischemic Stroke – Pipeline Review, H2 2011


          Aug 24, 2011: D-Pha
								
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