Age Related Macular Degeneration - Pipeline Review, H2 2011 by GlobalMarketsDirect

VIEWS: 11 PAGES: 195

More Info
									Age Related Macular Degeneration – Pipeline Review, H2 2011




  Age Related Macular Degeneration - Pipeline Review,
                       H2 2011
                                                                                          Reference Code: GMDHC1269IDB

                                                                                          Publication Date: August 2011




Age Related Macular Degeneration – Pipeline Review, H2 2011                                                       GMDHC1269IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied
                                                                                                                                         Page(1)
Age Related Macular Degeneration – Pipeline Review, H2 2011



Ta b le o f Co n te n ts
Table of Contents                                                                                                                  2
List of Tables                                                                                                                    10
List of Figures                                                                                                                   13
Introduction                                                                                                                      14
     Global Markets Direct Report Coverage                                                                                        14
Age Related Macular Degeneration Overview                                                                                         15
Therapeutics Development                                                                                                          16
     An Overview of Pipeline Products for Age Related Macular Degeneration                                                        16
Age Related Macular Degeneration Therapeutics under Development by Companies                                                      18
Age Related Macular Degeneration Therapeutics under Investigation by Universities/Institutes                                      23
Late Stage Products                                                                                                               26
     Comparative Analysis                                                                                                         26
Mid Clinical Stage Products                                                                                                       27
     Comparative Analysis                                                                                                         27
Early Clinical Stage Products                                                                                                     28
     Comparative Analysis                                                                                                         28
Discovery and Pre-Clinical Stage Products                                                                                         29
     Comparative Analysis                                                                                                         29
Age Related Macular Degeneration Therapeutics - Products under Development by Companies                                           30
Age Related Macular Degeneration Therapeutics - Products under Investigation by Universities/Institutes                           38
Companies Involved in Age Related Macular Degeneration Therapeutics Development                                                   40
     Alcon, Inc.                                                                                                                  40
     Genzyme Corporation                                                                                                          40
     Johnson & Johnson                                                                                                            41
     F. Hoffmann-La Roche Ltd.                                                                                                    41
     Abbott Laboratories                                                                                                          42
     Allergan, Inc.                                                                                                               42
     QLT Inc.                                                                                                                     43
     Advanced Cell Technology, Inc.                                                                                               43
     GlaxoSmithKline plc                                                                                                          44
     Santen Pharmaceutical Co., Ltd.                                                                                              44
     Oxford BioMedica plc                                                                                                         45
     Lux Biosciences, Inc.                                                                                                        45
     Light Sciences Oncology, Inc.                                                                                                46
     Optherion, Inc.                                                                                                              46
     Novartis AG                                                                                                                  47
     Pfizer Inc.                                                                                                                  47
     VasGene Therapeutics, Inc.                                                                                                   48
     ISTA Pharmaceuticals, Inc.                                                                                                   48
     Alchemia Limited                                                                                                             49
     iCo Therapeutics Inc.                                                                                                        49
     InNexus Biotechnology Inc.                                                                                                   50
     Lpath, Inc.                                                                                                                  50
     Mesoblast Ltd                                                                                                                51
     ReGenX Biosciences, LLC                                                                                                      51
     Ophthotech Corp.                                                                                                             52
     OXiGENE, Inc.                                                                                                                52


Age Related Macular Degeneration – Pipeline Review, H2 2011                                               GMDHC1269IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                                           Page(2)
Age Related Macular Degeneration – Pipeline Review, H2 2011


     Alexion Pharmaceuticals, Inc.                                                                                53
     Regeneron Pharmaceuticals, Inc.                                                                              53
     Progen Pharmaceuticals Limited                                                                               54
     Sirion Therapeutics, Inc.                                                                                    54
     Summit Corporation plc                                                                                       55
     ThromboGenics NV                                                                                             55
     Simcere Pharmaceutical Group                                                                                 56
     PolyMedix, Inc.                                                                                              56
     e-Therapeutics plc                                                                                           57
     NanoCarrier Co., Ltd.                                                                                        58
     R-Tech Ueno, Ltd.                                                                                            58
     Paloma Pharmaceuticals, Inc.                                                                                 59
     Digna Biotech, S.L.                                                                                          59
     Ceregene, Inc.                                                                                               60
     StemCells, Inc.                                                                                              60
     Ora Bio Ltd.                                                                                                 61
     Molecular Partners AG                                                                                        61
     Acucela Inc.                                                                                                 62
     Acceleron Pharma, Inc.                                                                                       62
     Applied Genetic Technologies Corporation                                                                     63
     Neovacs SA                                                                                                   63
     Cosmix Molecular Biologicals GmbH                                                                            64
     MAT Biopharma                                                                                                64
     InCode BioPharmaceutics, Inc.                                                                                65
     OcuCure Therapeutics, Inc.                                                                                   65
     Neurotech Pharmaceuticals, Inc.                                                                              66
     Gene Signal International SA.                                                                                66
     Promedior, Inc.                                                                                              67
     Iconic Therapeutics, Inc.                                                                                    67
     Inotek Pharmaceuticals Corporation                                                                           68
     Indus Biotech Private Limited                                                                                68
     Othera Pharmaceuticals, Inc.                                                                                 69
     Cardax Pharmaceuticals, Inc.                                                                                 69
     NOXXON Pharma AG                                                                                             70
     Adeona Pharmaceuticals, Inc.                                                                                 70
     Angstrom Pharmaceuticals, Inc.                                                                               71
     Alimera Sciences, Inc.                                                                                       71
     Taiwan Liposome Company                                                                                      72
     Biovista Inc.                                                                                                72
     Sirnaomics, Inc.                                                                                             73
     Resolvyx Pharmaceuticals, Inc                                                                                73
     Charlesson LLC.                                                                                              74
     KAI Pharmaceuticals Inc.                                                                                     74
     TaiGen Biotechnology Co., Ltd.                                                                               75
     TRACON Pharmaceuticals, Inc.                                                                                 75
     Kemin Industries, Inc.                                                                                       76
     OHR Pharmaceutical Inc.                                                                                      76
     Icon Bioscience, Inc.                                                                                        77




Age Related Macular Degeneration – Pipeline Review, H2 2011                               GMDHC1269IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                           Page(3)
Age Related Macular Degeneration – Pipeline Review, H2 2011


     Varinel, Inc.                                                                                                77
Age Related Macular Degeneration - Therapeutics Assessment                                                        78
     Assessment by Monotherapy Products                                                                           78
     Assessment by Combination Products                                                                           79
     Assessment by Route of Administration                                                                        80
     Assessment by Molecule Type                                                                                  83
Late Stage Drug Profiles                                                                                          86
     Lucentis - Drug Profile                                                                                      86
          Product Description                                                                                     86
          Mechanism of Action                                                                                     86
          R&D Progress                                                                                            86
     ACU-4429 - Drug Profile                                                                                      88
          Product Description                                                                                     88
          Mechanism of Action                                                                                     88
          R&D Progress                                                                                            88
     Perceiva - Drug Profile                                                                                      90
          Product Description                                                                                     90
          Mechanism of Action                                                                                     90
          R&D Progress                                                                                            90
     Rescula - Drug Profile                                                                                       92
          Product Description                                                                                     92
          Mechanism of Action                                                                                     92
          R&D Progress                                                                                            92
     Afinitor - Drug Profile                                                                                      93
          Product Description                                                                                     93
          Mechanism of Action                                                                                     93
          R&D Progress                                                                                            93
     Ocriplasmin - Drug Profile                                                                                   95
          Product Description                                                                                     95
          Mechanism of Action                                                                                     95
          R&D Progress                                                                                            95
     Soliris - Drug Profile                                                                                       97
          Product Description                                                                                     97
          Mechanism of Action                                                                                     97
          R&D Progress                                                                                            97
     Eylea - Drug Profile                                                                                         99
          Product Description                                                                                     99
          Mechanism of Action                                                                                     99
          R&D Progress                                                                                            99
     Eylea - Drug Profile                                                                                        101
          Product Description                                                                                    101
          Mechanism of Action                                                                                    101
          R&D Progress                                                                                           101
     E10030 - Drug Profile                                                                                       103
          Product Description                                                                                    103
          Mechanism of Action                                                                                    103
          R&D Progress                                                                                           103
     NT-501 - Drug Profile                                                                                       104




Age Related Macular Degeneration – Pipeline Review, H2 2011                               GMDHC1269IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                           Page(4)
Age Related Macular Degeneration – Pipeline Review, H2 2011


          Product Description                                                                                    104
          Mechanism of Action                                                                                    104
          R&D Progress                                                                                           104
     Aptocine - Drug Profile                                                                                     106
          Product Description                                                                                    106
          Mechanism of Action                                                                                    106
          R&D Progress                                                                                           106
     OT-551 - Drug Profile                                                                                       108
          Product Description                                                                                    108
          Mechanism of Action                                                                                    108
          R&D Progress                                                                                           108
     iCo-008 - Drug Profile                                                                                      109
          Product Description                                                                                    109
          Mechanism of Action                                                                                    109
          R&D Progress                                                                                           109
     PF-04523655 - Drug Profile                                                                                  110
          Product Description                                                                                    110
          Mechanism of Action                                                                                    110
          R&D Progress                                                                                           110
     RetinoStat - Drug Profile                                                                                   111
          Product Description                                                                                    111
          Mechanism of Action                                                                                    111
          R&D Progress                                                                                           111
     Infliximab + Sirolimus + Daclizumab - Drug Profile                                                          112
          Product Description                                                                                    112
          Mechanism of Action                                                                                    112
          R&D Progress                                                                                           112
     AL-39324 - Drug Profile                                                                                     113
          Product Description                                                                                    113
          Mechanism of Action                                                                                    113
          R&D Progress                                                                                           113
     Iluvien - Drug Profile                                                                                      114
          Product Description                                                                                    114
          Mechanism of Action                                                                                    114
          R&D Progress                                                                                           114
     ORA102 + Avastin - Drug Profile                                                                             115
          Product Description                                                                                    115
          Mechanism of Action                                                                                    115
          R&D Progress                                                                                           115
     AL-8309B - Drug Profile                                                                                     116
          Product Description                                                                                    116
          Mechanism of Action                                                                                    116
          R&D Progress                                                                                           116
     Stakel Mediated VTP Therapy - Drug Profile                                                                  117
          Product Description                                                                                    117
          Mechanism of Action                                                                                    117
          R&D Progress                                                                                           117
     Avastin - Drug Profile                                                                                      118




Age Related Macular Degeneration – Pipeline Review, H2 2011                               GMDHC1269IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                           Page(5)
Age Related Macular Degeneration – Pipeline Review, H2 2011


          Product Description                                                                                    118
          Mechanism of Action                                                                                    118
          R&D Progress                                                                                           118
     Ranibizumab + Verteporfin - Drug Profile                                                                    119
          Product Description                                                                                    119
          Mechanism of Action                                                                                    119
          R&D Progress                                                                                           119
     Pazopanib Eye Drop - Drug Profile                                                                           120
          Product Description                                                                                    120
          Mechanism of Action                                                                                    120
          R&D Progress                                                                                           120
     Lucentis + Dexamethasone + Visudyne - Drug Profile                                                          121
          Product Description                                                                                    121
          Mechanism of Action                                                                                    121
          R&D Progress                                                                                           121
     E10030 + Lucentis - Drug Profile                                                                            122
          Product Description                                                                                    122
          Mechanism of Action                                                                                    122
          R&D Progress                                                                                           122
     MP0112 - Drug Profile                                                                                       123
          Product Description                                                                                    123
          Mechanism of Action                                                                                    123
          R&D Progress                                                                                           123
     Lucentis + Bromfenac - Drug Profile                                                                         124
          Product Description                                                                                    124
          Mechanism of Action                                                                                    124
          R&D Progress                                                                                           124
     Visudyne + Lucentis - Drug Profile                                                                          125
          Product Description                                                                                    125
          Mechanism of Action                                                                                    125
          R&D Progress                                                                                           125
     Sirolimus - Drug Profile                                                                                    127
          Product Description                                                                                    127
          Mechanism of Action                                                                                    127
          R&D Progress                                                                                           127
     Evizon - Drug Profile                                                                                       128
          Product Description                                                                                    128
          Mechanism of Action                                                                                    128
          R&D Progress                                                                                           128
     Celebrex - Drug Profile                                                                                     129
          Product Description                                                                                    129
          Mechanism of Action                                                                                    129
          R&D Progress                                                                                           129
     Zybrestat - Drug Profile                                                                                    130
          Product Description                                                                                    130
          Mechanism of Action                                                                                    130
          R&D Progress                                                                                           130
     Avastin - Drug Profile                                                                                      131




Age Related Macular Degeneration – Pipeline Review, H2 2011                               GMDHC1269IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                           Page(6)
Age Related Macular Degeneration – Pipeline Review, H2 2011


          Product Description                                                                                    131
          Mechanism of Action                                                                                    131
          R&D Progress                                                                                           131
     Votrient - Drug Profile                                                                                     132
          Product Description                                                                                    132
          Mechanism of Action                                                                                    132
          R&D Progress                                                                                           132
     Verteporfin Photodynamic Therapy + Ranibizumab + Triamcinolone - Drug Profile                               134
          Product Description                                                                                    134
          Mechanism of Action                                                                                    134
          R&D Progress                                                                                           134
     Lucentis + Visudyne - Drug Profile                                                                          136
          Product Description                                                                                    136
          Mechanism of Action                                                                                    136
          R&D Progress                                                                                           136
     Lucentis + Visudyne - Drug Profile                                                                          137
          Product Description                                                                                    137
          Mechanism of Action                                                                                    137
          R&D Progress                                                                                           137
     Lucentis - Drug Profile                                                                                     138
          Product Description                                                                                    138
          Mechanism of Action                                                                                    138
          R&D Progress                                                                                           138
     RT-101 - Drug Profile                                                                                       139
          Product Description                                                                                    139
          Mechanism of Action                                                                                    139
          R&D Progress                                                                                           139
     Lucentis - Drug Profile                                                                                     140
          Product Description                                                                                    140
          Mechanism of Action                                                                                    140
          R&D Progress                                                                                           140
     CNTO 2476 - Drug Profile                                                                                    141
          Product Description                                                                                    141
          Mechanism of Action                                                                                    141
          R&D Progress                                                                                           141
     Avastin + Visudyne Photodynamic Therapy - Drug Profile                                                      142
          Product Description                                                                                    142
          Mechanism of Action                                                                                    142
          R&D Progress                                                                                           142
     Ozurdex + Lucentis - Drug Profile                                                                           143
          Product Description                                                                                    143
          Mechanism of Action                                                                                    143
          R&D Progress                                                                                           143
     Bevacizumab + Verteporfin Photodynamic Therapy - Drug Profile                                               144
          Product Description                                                                                    144
          Mechanism of Action                                                                                    144
          R&D Progress                                                                                           144
     Bevacizumab + Visudyne - Drug Profile                                                                       145




Age Related Macular Degeneration – Pipeline Review, H2 2011                               GMDHC1269IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                           Page(7)
Age Related Macular Degeneration – Pipeline Review, H2 2011


          Product Description                                                                                    145
          Mechanism of Action                                                                                    145
          R&D Progress                                                                                           145
     Adalimumab - Drug Profile                                                                                   146
          Product Description                                                                                    146
          Mechanism of Action                                                                                    146
          R&D Progress                                                                                           146
     Avastin - Drug Profile                                                                                      147
          Product Description                                                                                    147
          Mechanism of Action                                                                                    147
          R&D Progress                                                                                           147
     Avastin + Low Fluence Photodynamic Therapy - Drug Profile                                                   148
          Product Description                                                                                    148
          Mechanism of Action                                                                                    148
          R&D Progress                                                                                           148
     Avastin + Kenalog + Low Fluence Photodynamic Therapy - Drug Profile                                         149
          Product Description                                                                                    149
          Mechanism of Action                                                                                    149
          R&D Progress                                                                                           149
     KH902 - Drug Profile                                                                                        151
          Product Description                                                                                    151
          Mechanism of Action                                                                                    151
          R&D Progress                                                                                           151
     Lucentis + Visudyne - Drug Profile                                                                          153
          Product Description                                                                                    153
          Mechanism of Action                                                                                    153
          R&D Progress                                                                                           153
     Avastin - Drug Profile                                                                                      154
          Product Description                                                                                    154
          Mechanism of Action                                                                                    154
          R&D Progress                                                                                           154
     Dexamethasone + Ranibizumab - Drug Profile                                                                  155
          Product Description                                                                                    155
          Mechanism of Action                                                                                    155
          R&D Progress                                                                                           155
     Ranibizumab + Triamcinolone Acetonide - Drug Profile                                                        156
          Product Description                                                                                    156
          Mechanism of Action                                                                                    156
          R&D Progress                                                                                           156
     Verteporfin + Triamcinolone - Drug Profile                                                                  158
          Product Description                                                                                    158
          Mechanism of Action                                                                                    158
          R&D Progress                                                                                           158
     Verteporfin + Pegaptanib - Drug Profile                                                                     159
          Product Description                                                                                    159
          Mechanism of Action                                                                                    159
          R&D Progress                                                                                           159
     IBI-20089 + Lucentis - Drug Profile                                                                         160




Age Related Macular Degeneration – Pipeline Review, H2 2011                               GMDHC1269IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                           Page(8)
Age Related Macular Degeneration – Pipeline Review, H2 2011


          Product Description                                                                                                            160
          Mechanism of Action                                                                                                            160
          R&D Progress                                                                                                                   160
     ORA102 - Drug Profile                                                                                                               161
          Product Description                                                                                                            161
          Mechanism of Action                                                                                                            161
          R&D Progress                                                                                                                   161
     Bevacizumab - Drug Profile                                                                                                          162
          Product Description                                                                                                            162
          Mechanism of Action                                                                                                            162
          R&D Progress                                                                                                                   162
     ST-602 - Drug Profile                                                                                                               163
          Product Description                                                                                                            163
          Mechanism of Action                                                                                                            163
          R&D Progress                                                                                                                   163
     Pazopanib - Drug Profile                                                                                                            164
          Product Description                                                                                                            164
          Mechanism of Action                                                                                                            164
          R&D Progress                                                                                                                   164
     Lucentis + AL-78898A - Drug Profile                                                                                                 165
          Product Description                                                                                                            165
          Mechanism of Action                                                                                                            165
          R&D Progress                                                                                                                   165
     ESBA1008 - Drug Profile                                                                                                             166
          Product Description                                                                                                            166
          Mechanism of Action                                                                                                            166
          R&D Progress                                                                                                                   166
     Verteporfin Photodynamic Therapy + Triamcinolone - Drug Profile                                                                     167
          Product Description                                                                                                            167
          Mechanism of Action                                                                                                            167
          R&D Progress                                                                                                                   167
     Bevacizumab - Drug Profile                                                                                                          169
          Product Description                                                                                                            169
          Mechanism of Action                                                                                                            169
          R&D Progress                                                                                                                   169
     AGN-150998 - Drug Profile                                                                                                           170
          Product Description                                                                                                            170
          Mechanism of Action                                                                                                            170
          R&D Progress                                                                                                                   170
Age Related Macular Degeneration Therapeutics – Drug Profile Updates                                                                     171
Age Related Macular Degeneration Therapeutics - Discontinued Products                                                                    185
     Age Related Macular Degeneration - Featured News                                                                                    186
          Aug 22, 2011: Ohr Pharmaceutical Receives Key US Composition Of Matter Patent For Squalamine                                   186
          Aug 17, 2011: Regeneron To Present Data From EYLEA Clinical Studies At ASRS 2011 Annual Meeting                                186
          Aug 16, 2011: Regeneron Announces Review Of Biologics License Application For EYLEA Extended By Three Months By FDA            187
          Jul 14, 2011: ACT Announces First Patients Undergo Embryonic Stem Cell Transplantation Treatment For Stargardt's Disease And
          Macular Degeneration At UCLA's Jules Stein Eye Institute                                                                       187
          Jul 13, 2011: Ohr Pharmaceutical Announces Positive Animal Studies For New Squalamine Eye Drop For Wet-AMD                     188
          Jun 29,
								
To top