Nausea And Vomiting - Pipeline Review, H2 2011 by GlobalMarketsDirect

VIEWS: 2 PAGES: 160

More Info
									Nausea And Vomiting – Pipeline Review, H2 2011




          Nausea And Vomiting - Pipeline Review, H2 2011
                                                                                          Reference Code: GMDHC1268IDB

                                                                                          Publication Date: August 2011




Nausea And Vomiting – Pipeline Review, H2 2011                                                                    GMDHC1268IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied
                                                                                                                                         Page(1)
Nausea And Vomiting – Pipeline Review, H2 2011



Ta b le o f Co n te n ts
Table of Contents                                                                                                     2
List of Tables                                                                                                       11
List of Figures                                                                                                      12
Introduction                                                                                                         13
     Global Markets Direct Report Coverage                                                                           13
Nausea And Vomiting Overview                                                                                         14
Therapeutics Development                                                                                             15
     An Overview of Pipeline Products for Nausea And Vomiting                                                        15
Nausea And Vomiting Therapeutics under Development by Companies                                                      17
Nausea And Vomiting Therapeutics under Investigation by Universities/Institutes                                      19
Late Stage Products                                                                                                  23
     Comparative Analysis                                                                                            23
Mid Clinical Stage Products                                                                                          24
     Comparative Analysis                                                                                            24
Early Clinical Stage Products                                                                                        25
     Comparative Analysis                                                                                            25
Discovery and Pre-Clinical Stage Products                                                                            26
     Comparative Analysis                                                                                            26
Nausea And Vomiting Therapeutics - Products under Development by Companies                                           27
Nausea And Vomiting Therapeutics - Products under Investigation by Universities/Institutes                           30
Companies Involved in Nausea And Vomiting Therapeutics Development                                                   34
     BioDelivery Sciences International, Inc.                                                                        34
     GlaxoSmithKline plc                                                                                             34
     Merck & Co., Inc.                                                                                               35
     A.P. Pharma, Inc.                                                                                               35
     Archimedes Pharma Limited                                                                                       36
     Aphios Corporation                                                                                              36
     Axcan Pharma Inc.                                                                                               37
     Eisai Co., Ltd.                                                                                                 37
     Ono Pharmaceutical Co., Ltd.                                                                                    38
     ProStrakan Group plc                                                                                            38
     BioAlliance Pharma SA                                                                                           39
     Teikoku Pharma USA, Inc.                                                                                        39
     Dharma Therapeutics, Inc.                                                                                       40
     Simbec Research Ltd                                                                                             40
     Helsinn Healthcare S.A.                                                                                         41
     Victory Pharma, Inc.                                                                                            41
     Ikano Therapeutics, Inc.                                                                                        42
     Almac Discovery Ltd.                                                                                            42
     Acacia Pharma Ltd.                                                                                              43
Nausea And Vomiting - Therapeutics Assessment                                                                        44
     Assessment by Monotherapy Products                                                                              44
     Assessment by Combination Products                                                                              45
     Assessment by Route of Administration                                                                           46
     Assessment by Molecule Type                                                                                     48
Drug Profiles                                                                                                        50
     Rolapitant - Drug Profile                                                                                       50


Nausea And Vomiting – Pipeline Review, H2 2011                                               GMDHC1268IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                              Page(2)
Nausea And Vomiting – Pipeline Review, H2 2011


          Product Description                                                                                     50
          Mechanism of Action                                                                                     50
          R&D Progress                                                                                            50
     EUR 1025 - Drug Profile                                                                                      51
          Product Description                                                                                     51
          Mechanism of Action                                                                                     51
          R&D Progress                                                                                            51
     AB-1001 - Drug Profile                                                                                       52
          Product Description                                                                                     52
          Mechanism of Action                                                                                     52
          R&D Progress                                                                                            52
     Antiemetic - Drug Profile                                                                                    54
          Product Description                                                                                     54
          Mechanism of Action                                                                                     54
          R&D Progress                                                                                            54
     Ondansetron Spray - Drug Profile                                                                             55
          Product Description                                                                                     55
          Mechanism of Action                                                                                     55
          R&D Progress                                                                                            55
     Ondansetron Spray - Drug Profile                                                                             56
          Product Description                                                                                     56
          Mechanism of Action                                                                                     56
          R&D Progress                                                                                            56
     Sancuso - Drug Profile                                                                                       57
          Product Description                                                                                     57
          Mechanism of Action                                                                                     57
          R&D Progress                                                                                            57
     APF530 - Drug Profile                                                                                        58
          Product Description                                                                                     58
          Mechanism of Action                                                                                     58
          R&D Progress                                                                                            58
     RHB-102 - Drug Profile                                                                                       59
          Product Description                                                                                     59
          Mechanism of Action                                                                                     59
          R&D Progress                                                                                            59
     MGX006 - Drug Profile                                                                                        60
          Product Description                                                                                     60
          Mechanism of Action                                                                                     60
          R&D Progress                                                                                            60
     Dexamethasone - Drug Profile                                                                                 61
          Product Description                                                                                     61
          Mechanism of Action                                                                                     61
          R&D Progress                                                                                            61
     GW597599 - Drug Profile                                                                                      62
          Product Description                                                                                     62
          Mechanism of Action                                                                                     62
          R&D Progress                                                                                            62
     Palonosetron - Drug Profile                                                                                  63




Nausea And Vomiting – Pipeline Review, H2 2011                                            GMDHC1268IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                           Page(3)
Nausea And Vomiting – Pipeline Review, H2 2011


          Product Description                                                                                              63
          Mechanism of Action                                                                                              63
          R&D Progress                                                                                                     63
     BEMA Granisetron - Drug Profile                                                                                       64
          Product Description                                                                                              64
          Mechanism of Action                                                                                              64
          R&D Progress                                                                                                     64
     Diphenhydramine hydrochloride + Dexamethasone + Lorazepam + Ondansetron hydrochloride - Drug Profile                  65
          Product Description                                                                                              65
          Mechanism of Action                                                                                              65
          R&D Progress                                                                                                     65
     Aprepitant + Ondansetron - Drug Profile                                                                               66
          Product Description                                                                                              66
          Mechanism of Action                                                                                              66
          R&D Progress                                                                                                     66
     Granisetron + Dexamethasone + Prochlorperazine - Drug Profile                                                         67
          Product Description                                                                                              67
          Mechanism of Action                                                                                              67
          R&D Progress                                                                                                     67
     Aprepitant + Palonosetron + Dexamethasone for Nausea and Vomiting - Drug Profile                                      69
          Product Description                                                                                              69
          Mechanism of Action                                                                                              69
          R&D Progress                                                                                                     69
     Palonosetron - Drug Profile                                                                                           70
          Product Description                                                                                              70
          Mechanism of Action                                                                                              70
          R&D Progress                                                                                                     70
     Aprepitant - Drug Profile                                                                                             71
          Product Description                                                                                              71
          Mechanism of Action                                                                                              71
          R&D Progress                                                                                                     71
     Dexamethasone - Drug Profile                                                                                          72
          Product Description                                                                                              72
          Mechanism of Action                                                                                              72
          R&D Progress                                                                                                     72
     Fosaprepitant Dimeglumine + Palonosetron Hydrochloride + Dexamethasone - Drug Profile                                 73
          Product Description                                                                                              73
          Mechanism of Action                                                                                              73
          R&D Progress                                                                                                     73
     APF530 + Dexamethasone - Drug Profile                                                                                 75
          Product Description                                                                                              75
          Mechanism of Action                                                                                              75
          R&D Progress                                                                                                     75
     Palonosetron - Drug Profile                                                                                           76
          Product Description                                                                                              76
          Mechanism of Action                                                                                              76
          R&D Progress                                                                                                     76
     Ondansetron Hydrochloride - Drug Profile                                                                              77




Nausea And Vomiting – Pipeline Review, H2 2011                                                     GMDHC1268IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                                    Page(4)
Nausea And Vomiting – Pipeline Review, H2 2011


          Product Description                                                                                              77
          Mechanism of Action                                                                                              77
          R&D Progress                                                                                                     77
     Fosaprepitant for Nausea and Vomiting (Oregon Health and Science University) - Drug Profile                           78
          Product Description                                                                                              78
          Mechanism of Action                                                                                              78
          R&D Progress                                                                                                     78
     Dexamethasone - Drug Profile                                                                                          79
          Product Description                                                                                              79
          Mechanism of Action                                                                                              79
          R&D Progress                                                                                                     79
     Dexamethasone - Drug Profile                                                                                          80
          Product Description                                                                                              80
          Mechanism of Action                                                                                              80
          R&D Progress                                                                                                     80
     Nicotinell - Drug Profile                                                                                             81
          Product Description                                                                                              81
          Mechanism of Action                                                                                              81
          R&D Progress                                                                                                     81
     ondansetron - Drug Profile                                                                                            82
          Product Description                                                                                              82
          Mechanism of Action                                                                                              82
          R&D Progress                                                                                                     82
     Dronabinol - Drug Profile                                                                                             83
          Product Description                                                                                              83
          Mechanism of Action                                                                                              83
          R&D Progress                                                                                                     83
     Casopitant + Ondansetron + Dexamethasone - Drug Profile                                                               84
          Product Description                                                                                              84
          Mechanism of Action                                                                                              84
          R&D Progress                                                                                                     84
     Lerisetron - Drug Profile                                                                                             86
          Product Description                                                                                              86
          Mechanism of Action                                                                                              86
          R&D Progress                                                                                                     86
     Casopitant + Cyclophosphamide - Drug Profile                                                                          87
          Product Description                                                                                              87
          Mechanism of Action                                                                                              87
          R&D Progress                                                                                                     87
     Aprepitant + Ramosetron + Dexamethasone - Drug Profile                                                                88
          Product Description                                                                                              88
          Mechanism of Action                                                                                              88
          R&D Progress                                                                                                     88
     MK0869 - Drug Profile                                                                                                 89
          Product Description                                                                                              89
          Mechanism of Action                                                                                              89
          R&D Progress                                                                                                     89
     Emend - Drug Profile                                                                                                  90




Nausea And Vomiting – Pipeline Review, H2 2011                                                     GMDHC1268IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                                    Page(5)
Nausea And Vomiting – Pipeline Review, H2 2011


          Product Description                                                                                     90
          Mechanism of Action                                                                                     90
          R&D Progress                                                                                            90
     MK0869 + MK0517 - Drug Profile                                                                               91
          Product Description                                                                                     91
          Mechanism of Action                                                                                     91
          R&D Progress                                                                                            91
     Fosaprepitant dimeglumine + Dexamethasone + Palonosetron - Drug Profile                                      92
          Product Description                                                                                     92
          Mechanism of Action                                                                                     92
          R&D Progress                                                                                            92
     Granisetron - Drug Profile                                                                                   93
          Product Description                                                                                     93
          Mechanism of Action                                                                                     93
          R&D Progress                                                                                            93
     Ondansetron - Drug Profile                                                                                   94
          Product Description                                                                                     94
          Mechanism of Action                                                                                     94
          R&D Progress                                                                                            94
     Granisetron + Dexamethasone - Drug Profile                                                                   95
          Product Description                                                                                     95
          Mechanism of Action                                                                                     95
          R&D Progress                                                                                            95
     Prochlorperazine - Drug Profile                                                                              96
          Product Description                                                                                     96
          Mechanism of Action                                                                                     96
          R&D Progress                                                                                            96
     Ondansetron - Drug Profile                                                                                   97
          Product Description                                                                                     97
          Mechanism of Action                                                                                     97
          R&D Progress                                                                                            97
     Ramosetron + Aprepitant + Dexamethasone - Drug Profile                                                       98
          Product Description                                                                                     98
          Mechanism of Action                                                                                     98
          R&D Progress                                                                                            98
     Dexamethasone - Drug Profile                                                                                 99
          Product Description                                                                                     99
          Mechanism of Action                                                                                     99
          R&D Progress                                                                                            99
     Thiamine - Drug Profile                                                                                     100
          Product Description                                                                                    100
          Mechanism of Action                                                                                    100
          R&D Progress                                                                                           100
     Aprepitant + Ondansetron + GW679769 + Dexamethasone - Drug Profile                                          101
          Product Description                                                                                    101
          Mechanism of Action                                                                                    101
          R&D Progress                                                                                           101
     Ondansetron - Drug Profile                                                                                  102




Nausea And Vomiting – Pipeline Review, H2 2011                                            GMDHC1268IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                           Page(6)
Nausea And Vomiting – Pipeline Review, H2 2011


          Product Description                                                                                                  102
          Mechanism of Action                                                                                                  102
          R&D Progress                                                                                                         102
     Fosaprepitant dimeglumine + Ondansetron + Dexamethasone - Drug Profile                                                    103
          Product Description                                                                                                  103
          Mechanism of Action                                                                                                  103
          R&D Progress                                                                                                         103
     Zindol - Drug Profile                                                                                                     104
          Product Description                                                                                                  104
          Mechanism of Action                                                                                                  104
          R&D Progress                                                                                                         104
     Gabapentin - Drug Profile                                                                                                 105
          Product Description                                                                                                  105
          Mechanism of Action                                                                                                  105
          R&D Progress                                                                                                         105
     Ramosetron - Drug Profile                                                                                                 106
          Product Description                                                                                                  106
          Mechanism of Action                                                                                                  106
          R&D Progress                                                                                                         106
     Erythromycin - Drug Profile                                                                                               107
          Product Description                                                                                                  107
          Mechanism of Action                                                                                                  107
          R&D Progress                                                                                                         107
     Carboplatin + Cyclophosphamide + Doxorubicin hydrochloride + Granisetron hydrochloride - Drug Profile                     108
          Product Description                                                                                                  108
          Mechanism of Action                                                                                                  108
          R&D Progress                                                                                                         109
     Granisetron - Drug Profile                                                                                                110
          Product Description                                                                                                  110
          Mechanism of Action                                                                                                  110
          R&D Progress                                                                                                         110
     Dexamethasone - Drug Profile                                                                                              111
          Product Description                                                                                                  111
          Mechanism of Action                                                                                                  111
          R&D Progress                                                                                                         111
     Dexamethasone - Drug Profile                                                                                              112
          Product Description                                                                                                  112
          Mechanism of Action                                                                                                  112
          R&D Progress                                                                                                         112
     Aprepitant + Palonosetron + Dexamethasone - Drug Profile                                                                  113
          Product Description                                                                                                  113
          Mechanism of Action                                                                                                  113
          R&D Progress                                                                                                         113
     Ondansetron - Drug Profile                                                                                                114
          Product Description                                                                                                  114
          Mechanism of Action                                                                                                  114
          R&D Progress                                                                                                         114
     Domperidone - Drug Profile                                                                                                115




Nausea And Vomiting – Pipeline Review, H2 2011                                                          GMDHC1268IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                                         Page(7)
Nausea And Vomiting – Pipeline Review, H2 2011


          Product Description                                                                                    115
          Mechanism of Action                                                                                    115
          R&D Progress                                                                                           115
     APD421 - Drug Profile                                                                                       116
          Product Description                                                                                    116
          Mechanism of Action                                                                                    116
          R&D Progress                                                                                           116
     Dexamethason + Metoclopramide - Drug Profile                                                                117
          Product Description                                                                                    117
          Mechanism of Action                                                                                    117
          R&D Progress                                                                                           117
     Dexamethasone + Dronabinol + Palonosetron hydrochloride - Drug Profile                                      118
          Product Description                                                                                    118
          Mechanism of Action                                                                                    118
          R&D Progress                                                                                           118
     Dexamethasone + Gabapentin - Drug Profile                                                                   120
          Product Description                                                                                    120
          Mechanism of Action                                                                                    120
          R&D Progress                                                                                           120
     Dexamethasone + Granisetron - Drug Profile                                                                  122
          Product Description                                                                                    122
          Mechanism of Action                                                                                    122
          R&D Progress                                                                                           122
     palonosetron + Granisetron - Drug Profile                                                                   123
          Product Description                                                                                    123
          Mechanism of Action                                                                                    123
          R&D Progress                                                                                           123
     fosaprepitant - Drug Profile                                                                                124
          Product Description                                                                                    124
          Mechanism of Action                                                                                    124
          R&D Progress         
								
To top