Thyroid Cancer - Pipeline Review, H2 2011 by GlobalMarketsDirect

VIEWS: 2 PAGES: 147

Thyroid Cancer - Pipeline Review, H2 2011

Summary

Global Markets Direct’s, 'Thyroid Cancer - Pipeline Review, H2 2011', provides an overview of the Thyroid Cancer therapeutic pipeline. This report provides information on the therapeutic development for Thyroid Cancer, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Thyroid Cancer. 'Thyroid Cancer - Pipeline Review, H2 2011' is built using data and information sourced from Global Markets Direct’s proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct’s team.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

- A snapshot of the global therapeutic scenario for Thyroid Cancer.
- A review of the Thyroid Cancer products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
- Coverage of products based on various stages of development ranging from discovery till registration stages.
- A feature on pipeline projects on the basis of monotherapy and combined therapeutics.
- Coverage of the Thyroid Cancer pipeline on the basis of route of administration and molecule type.
- Profiles of late-stage pipeline products featuring sections on product description, mechanism of action and research & development progress.
- Key discontinued pipeline projects.
- Latest news and deals relating to the products.

Reasons to buy

- Identify and understand important and diverse types of therapeutics under development for Thyroid Cancer.
- Identify emerging players with potentially strong product portfolio and design effective counter-strategies to gain c

More Info
									Thyroid Cancer – Pipeline Review, H2 2011




                    Thyroid Cancer - Pipeline Review, H2 2011
                                                                                          Reference Code: GMDHC1238IDB

                                                                                          Publication Date: August 2011




Thyroid Cancer – Pipeline Review, H2 2011                                                                         GMDHC1238IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied
                                                                                                                                         Page(1)
Thyroid Cancer – Pipeline Review, H2 2011



Ta b le o f Co n te n ts
Table of Contents                                                                                                  2
List of Tables                                                                                                     9
List of Figures                                                                                                   10
Introduction                                                                                                      11
     Global Markets Direct Report Coverage                                                                        11
Thyroid Cancer Overview                                                                                           12
Therapeutics Development                                                                                          13
     An Overview of Pipeline Products for Thyroid Cancer                                                          13
Thyroid Cancer Therapeutics under Development by Companies                                                        15
Thyroid Cancer Therapeutics under Investigation by Universities/Institutes                                        17
Late Stage Products                                                                                               21
     Comparative Analysis                                                                                         21
Mid Clinical Stage Products                                                                                       22
     Comparative Analysis                                                                                         22
Early Clinical Stage Products                                                                                     23
     Comparative Analysis                                                                                         23
Discovery and Pre-Clinical Stage Products                                                                         24
     Comparative Analysis                                                                                         24
Thyroid Cancer Therapeutics - Products under Development by Companies                                             25
Thyroid Cancer Therapeutics - Products under Investigation by Universities/Institutes                             27
Companies Involved in Thyroid Cancer Therapeutics Development                                                     30
     F. Hoffmann-La Roche Ltd.                                                                                    30
     Amgen Inc.                                                                                                   30
     AstraZeneca PLC                                                                                              31
     Daiichi Sankyo Company, Ltd                                                                                  31
     Bio-Path Holdings, Inc.                                                                                      32
     Novartis AG                                                                                                  32
     Eisai Co., Ltd.                                                                                              33
     Pfizer Inc.                                                                                                  33
     Exelixis, Inc.                                                                                               34
     Bayer AG                                                                                                     34
     MannKind Corporation                                                                                         35
     OXiGENE, Inc.                                                                                                35
     Sareum Holdings plc                                                                                          36
     Vascular Biogenics Ltd.                                                                                      36
Thyroid Cancer - Therapeutics Assessment                                                                          37
     Assessment by Monotherapy Products                                                                           37
     Assessment by Combination Products                                                                           38
     Assessment by Route of Administration                                                                        39
     Assessment by Molecule Type                                                                                  41
Drug Profiles                                                                                                     43
     E7080 - Drug Profile                                                                                         43
          Product Description                                                                                     43
          Mechanism of Action                                                                                     43
          R&D Progress                                                                                            43
     Motesanib - Drug Profile                                                                                     45
          Product Description                                                                                     45


Thyroid Cancer – Pipeline Review, H2 2011                                                 GMDHC1238IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                           Page(2)
Thyroid Cancer – Pipeline Review, H2 2011


          Mechanism of Action                                                                                     45
          R&D Progress                                                                                            45
     Pasireotide - Drug Profile                                                                                   47
          Product Description                                                                                     47
          Mechanism of Action                                                                                     47
          R&D Progress                                                                                            47
     Nexavar - Drug Profile                                                                                       49
          Product Description                                                                                     49
          Mechanism of Action                                                                                     49
          R&D Progress                                                                                            49
     Axitinib - Drug Profile                                                                                      50
          Product Description                                                                                     50
          Mechanism of Action                                                                                     50
          R&D Progress                                                                                            50
     Caprelsa - Drug Profile                                                                                      52
          Product Description                                                                                     52
          Mechanism of Action                                                                                     52
          R&D Progress                                                                                            52
     Caprelsa - Drug Profile                                                                                      54
          Product Description                                                                                     54
          Mechanism of Action                                                                                     54
          R&D Progress                                                                                            54
     MKC1106-PP - Drug Profile                                                                                    56
          Product Description                                                                                     56
          Mechanism of Action                                                                                     56
          R&D Progress                                                                                            56
     LBH589 - Drug Profile                                                                                        57
          Product Description                                                                                     57
          Mechanism of Action                                                                                     57
          R&D Progress                                                                                            57
     Zelboraf - Drug Profile                                                                                      59
          Product Description                                                                                     59
          Mechanism of Action                                                                                     59
          R&D Progress                                                                                            59
     Polo-Like Kinase 1 - Drug Profile                                                                            61
          Product Description                                                                                     61
          Mechanism of Action                                                                                     61
          R&D Progress                                                                                            61
     B-RAF - Drug Profile                                                                                         62
          Product Description                                                                                     62
          Mechanism of Action                                                                                     62
          R&D Progress                                                                                            62
     Afinitor - Drug Profile                                                                                      63
          Product Description                                                                                     63
          Mechanism of Action                                                                                     63
          R&D Progress                                                                                            63
     VB-111 - Drug Profile                                                                                        65
          Product Description                                                                                     65




Thyroid Cancer – Pipeline Review, H2 2011                                                 GMDHC1238IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                           Page(3)
Thyroid Cancer – Pipeline Review, H2 2011


          Mechanism of Action                                                                                     65
          R&D Progress                                                                                            65
     BP-100-2.01 - Drug Profile                                                                                   66
          Product Description                                                                                     66
          Mechanism of Action                                                                                     66
          R&D Progress                                                                                            66
     R935788 - Drug Profile                                                                                       67
          Product Description                                                                                     67
          Mechanism of Action                                                                                     67
          R&D Progress                                                                                            67
     CP-4033 - Drug Profile                                                                                       68
          Product Description                                                                                     68
          Mechanism of Action                                                                                     68
          R&D Progress                                                                                            68
     Gleevec + Dacarbazine + Xeloda - Drug Profile                                                                69
          Product Description                                                                                     69
          Mechanism of Action                                                                                     69
          R&D Progress                                                                                            69
     Iressa - Drug Profile                                                                                        70
          Product Description                                                                                     70
          Mechanism of Action                                                                                     70
          R&D Progress                                                                                            70
     BAY 43-9006 - Drug Profile                                                                                   71
          Product Description                                                                                     71
          Mechanism of Action                                                                                     71
          R&D Progress                                                                                            71
     Celecoxib - Drug Profile                                                                                     72
          Product Description                                                                                     72
          Mechanism of Action                                                                                     72
          R&D Progress                                                                                            72
     Pazopanib Hydrochloride - Drug Profile                                                                       73
          Product Description                                                                                     73
          Mechanism of Action                                                                                     73
          R&D Progress                                                                                            73
     Vorinostat - Drug Profile                                                                                    74
          Product Description                                                                                     74
          Mechanism of Action                                                                                     74
          R&D Progress                                                                                            74
     FR901228 - Drug Profile                                                                                      75
          Product Description                                                                                     75
          Mechanism of Action                                                                                     75
          R&D Progress                                                                                            75
     Nexavar - Drug Profile                                                                                       76
          Product Description                                                                                     76
          Mechanism of Action                                                                                     76
          R&D Progress                                                                                            76
     Thalidomide - Drug Profile                                                                                   77
          Product Description                                                                                     77




Thyroid Cancer – Pipeline Review, H2 2011                                                 GMDHC1238IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                           Page(4)
Thyroid Cancer – Pipeline Review, H2 2011


          Mechanism of Action                                                                                          77
          R&D Progress                                                                                                 77
     Lithium Carbonate - Drug Profile                                                                                  79
          Product Description                                                                                          79
          Mechanism of Action                                                                                          79
          R&D Progress                                                                                                 79
     XL184 + Rosiglitazone - Drug Profile                                                                              80
          Product Description                                                                                          80
          Mechanism of Action                                                                                          80
          R&D Progress                                                                                                 80
     Temsirolimus + Sorafenib - Drug Profile                                                                           81
          Product Description                                                                                          81
          Mechanism of Action                                                                                          81
          R&D Progress                                                                                                 81
     Depakote - Drug Profile                                                                                           82
          Product Description                                                                                          82
          Mechanism of Action                                                                                          82
          R&D Progress                                                                                                 82
     Zactima + Velcade - Drug Profile                                                                                  83
          Product Description                                                                                          83
          Mechanism of Action                                                                                          83
          R&D Progress                                                                                                 83
     Irinotecan Hydrochloride - Drug Profile                                                                           84
          Product Description                                                                                          84
          Mechanism of Action                                                                                          84
          R&D Progress                                                                                                 84
     Revlimid - Drug Profile                                                                                           86
          Product Description                                                                                          86
          Mechanism of Action                                                                                          86
          R&D Progress                                                                                                 86
     Thalidomide - Drug Profile                                                                                        87
          Product Description                                                                                          87
          Mechanism of Action                                                                                          87
          R&D Progress                                                                                                 87
     Afinitor - Drug Profile                                                                                           88
          Product Description                                                                                          88
          Mechanism of Action                                                                                          88
          R&D Progress                                                                                                 88
     Hydroxyurea + Fluorouracil + Paclitaxel + Filgrastim + Radiation therapy - Drug Profile                           89
          Product Description                                                                                          89
          Mechanism of Action                                                                                          89
          R&D Progress                                                                                                 89
     Romidepsin - Drug Profile                                                                                         90
          Product Description                                                                                          90
          Mechanism of Action                                                                                          90
          R&D Progress                                                                                                 90
     Recombinant thyrotropin - Drug Profile                                                                            91
          Product Description                                                                                          91




Thyroid Cancer – Pipeline Review, H2 2011                                                      GMDHC1238IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                                Page(5)
Thyroid Cancer – Pipeline Review, H2 2011


          Mechanism of Action                                                                                     91
          R&D Progress                                                                                            91
     pemetrexed + paclitaxel - Drug Profile                                                                       92
          Product Description                                                                                     92
          Mechanism of Action                                                                                     92
          R&D Progress                                                                                            92
     Zybrestat + Carboplatin + Paclitaxel - Drug Profile                                                          93
          Product Description                                                                                     93
          Mechanism of Action                                                                                     93
          R&D Progress                                                                                            93
     LBH589 - Drug Profile                                                                                        95
          Product Description                                                                                     95
          Mechanism of Action                                                                                     95
          R&D Progress                                                                                            95
     RAD001 - Drug Profile                                                                                        96
          Product Description                                                                                     96
          Mechanism of Action                                                                                     96
          R&D Progress                                                                                            96
     Temsirolimus + Vinorelbine Ditartrate - Drug Profile                                                         97
          Product Description                                                                                     97
          Mechanism of Action                                                                                     97
          R&D Progress                                                                                            97
     Taxol - Drug Profile                                                                                         99
          Product Description                                                                                     99
          Mechanism of Action                                                                                     99
          R&D Progress                                                                                            99
     Valproic Acid - Drug Profile                                                                                100
          Product Description                                                                                    100
          Mechanism of Action                                                                                    100
          R&D Progress                                                                                           100
     Aflibercept + Radiation theraphy - Drug Profile                                                             101
          Product Description                                                                                    101
          Mechanism of Action                                                                                    101
          R&D Progress                                                                                           101
     Everolimus + Sorafenib - Drug Profile                                                                       102
          Product Description                                                                                    102
          Mechanism of Action                                                                                    102
          R&D Progress                                                                                           102
     Fostamatinib - Drug Profile                                                                                 103
          Product Description                                                                                    103
          Mechanism of Action                                                                                    103
          R&D Progress                                                                                           103
     Sunitinib - Drug Profile                                                                                    104
          Product Description                                                                                    104
          Mechanism of Action                                                                                    104
          R&D Progress                                                                                           104
     Sorafenib (nexavar) - Drug Profile                                                                          105
          Product Description                                                                                    105




Thyroid Cancer – Pipeline Review, H2 2011                                                 GMDHC1238IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                           Page(6)
Thyroid Cancer – Pipeline Review, H2 2011


          Mechanism of Action                                                                                    105
          R&D Progress                                                                                           105
     Lithium Carbonate - Drug Profile                                                                            106
          Product Description                                                                                    106
          Mechanism of Action                                                                                    106
          R&D Progress                                                                                           106
     BAY 43-9006 - Drug Profile                                                                                  107
          Product Description                                                                                    107
          Mechanism of Action                                                                                    107
          R&D Progress                                                                                           107
     Thyroid-Stimulating Hormone + Iodine I 131 - Drug Profile                                                   108
          Product Description                                                                                    108
          Mechanism of Action                                                                                    108
          R&D Progress                                                                                           109
     AG-013736 - Drug Profile                                                                                    110
          Product Description                                                                                    110
          Mechanism of Action                                                                                    110
          R&D Progress                                                                                           110
     Bortezomib - Drug Profile                                                                                   111
          Product Description                                                                                    111
          Mechanism of Action                                                                                    111
          R&D Progress                                                                                           111
     Combretastatin A4 phosphate - Drug Profile                                                                  112
          Product Description                                                                                    112
          Mechanism of Action                                                                                    112
          R&D Progress                                                                                           112
     Rosiglitazone Maleate - Drug Profile                                                                        113
          Product Description                                                                                    113
          Mechanism of Action                                                                                    113
          R&D Progress                                                                                           113
     Paclitaxel + Pazopanib + Radiation Therapy - Drug Profile                                                   114
          Product Description                                                                                    114
          Mechanism of Action                                                                                    114
          R&D Progress                                                                                           114
     Cisplatin + Crolibulin - Drug Profile                                                                       116
          Product Description                                                                                    116
          Mechanism of Action                                                                                    116
          R&D Progress                                                                                           116
     Sorafenib - Drug Profile                                                                                    117
          Product Description                                                                                    117
          Mechanism of Action                                                                                    117
          R&D Progress                                                                                           117
     Sutent - Drug Profile                                                                                       118
          Product Description                                                                                    118
          Mechanism of Action                                                                                    118
          R&D Progress                                                                                           118
     Cediranib Maleate + Lenalidomide - Drug Profile                                                             119
          Product Description                                                                                    119




Thyroid Cancer – Pipeline Review, H2 2011                                                 GMDHC1238IDB / Pub August 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                           Page(7)
Thyroid Cancer – Pipeline Review, H2 2011


          Mechanism of Action                                                                                                             119
          R&D Progress                                                                                                                    119
   
								
To top