Metastatic Hepatocellular Carcinoma (HCC) - Pipeline Review, Q2 2011 by GlobalMarketsDirect

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									Metastatic Hepatocellular Carcinoma (HCC) – Pipeline Review, Q2 2011




  Metastatic Hepatocellular Carcinoma (HCC) - Pipeline
                   Review, Q2 2011
                                                                                          Reference Code: GMDHC1066IDB

                                                                                          Publication Date: April 2011




Metastatic Hepatocellular Carcinoma (HCC) – Pipeline Review, Q2 2011                                          GMDHC1066IDB / Pub April 2011

© Global Markets Direct. This report is a licensed product and is not to be photocopied                                             Page(1)
Metastatic Hepatocellular Carcinoma (HCC) – Pipeline Review, Q2 2011



Ta b le o f Co n te n ts
Table of Contents                                                                                                                         2
List of Tables                                                                                                                            4
List of Figures                                                                                                                           5
Introduction                                                                                                                              6
    Global Markets Direct Report Coverage                                                                                                 6
Metastatic Hepatocellular Carcinoma (HCC) Overview                                                                                        7
Therapeutics Development                                                                                                                  8
    An Overview of Pipeline Products for Metastatic Hepatocellular Carcinoma (HCC)                                                        8
Metastatic Hepatocellular Carcinoma (HCC) Therapeutics under Development by Companies                                                    10
Metastatic Hepatocellular Carcinoma (HCC) Therapeutics under Investigation by Universities/Institutes                                    11
Late Stage Products                                                                                                                      13
    Comparative Analysis                                                                                                                 13
Mid Clinical Stage Products                                                                                                              14
    Comparative Analysis                                                                                                                 14
Early Clinical Stage Products                                                                                                            15
    Comparative Analysis                                                                                                                 15
Metastatic Hepatocellular Carcinoma (HCC) Therapeutics - Products under Development by Companies                                         16
Metastatic Hepatocellular Carcinoma (HCC) Therapeutics - Products under Investigation by Universities/Institutes                         17
Companies Involved in Metastatic Hepatocellular Carcinoma (HCC) Therapeutics Development                                                 18
    F. Hoffmann-La Roche Ltd.                                                                                                            18
    Bayer AG                                                                                                                             18
    KAEL-GemVax                                                                                                                          19
Metastatic Hepatocellular Carcinoma (HCC) - Therapeutics Assessment                                                                      20
    Assessment by Monotherapy Products                                                                                                   20
    Assessment by Combination Products                                                                                                   21
    Assessment by Route of Administration                                                                                                22
    Assessment by Molecule Type                                                                                                          24
Drug Profiles                                                                                                                            26
    RG7686 - Drug Profile                                                                                                                26
         Product Description                                                                                                             26
         Mechanism of Action                                                                                                             26
         R&D Progress                                                                                                                    26
    GV1001 - Drug Profile                                                                                                                27
         Product Description                                                                                                             27
         Mechanism of Action                                                                                                             27
         R&D Progress                                                                                                                    27
    Zavedos - Drug Profile                                                                                                               29
         Product Description                                                                                                             29
         Mechanism of Action                                                                                                             29
         R&D Progress                                                                                                                    29
    Thalidomide + Radiation Therapy - Drug Profile                                                                                       30
         Product Description                                                                                                             30
         Mechanism of Action                                                                                                             30
         R&D Progress                                                                                                                    30
    Sorafenib for Liver Metastasis - Drug Profile                                                                                        31
         Product Description                                                                                                             31
         Mechanism of Action                                                                                                             31


Metastatic Hepatocellular Carcinoma (HCC) – Pipeline Review, Q2 2011                                               GMDHC1066IDB / Pub April 2011

© Global Markets Direct. This report is a licensed product and is not to be photocopied                                                 Page(2)
Metastatic Hepatocellular Carcinoma (HCC) – Pipeline Review, Q2 2011


         R&D Progress                                                                                                       31
    Thado + Ufur - Drug Profile                                                                                             32
         Product Description                                                                                                32
         Mechanism of Action                                                                                                32
         R&D Progress                                                                                                       32
    GC33 + Nexavar - Drug Profile                                                                                           34
         Product Description                                                                                                34
         Mechanism of Action                                                                                                34
         R&D Progress                                                                                                       34
    Sorafenib + Everolimus - Drug Profile                                                                                   35
         Product Description                                                                                                35
         Mechanism of Action                                                                                                35
         R&D Progress                                                                                                       35
    Nexavar + Doxorubicin - Drug Profile                                                                                    36
         Product Description                                                                                                36
         Mechanism of Action                                                                                                36
         R&D Progress                                                                                                       36
    Sirolimus - Drug Profile                                                                                                37
         Product Description                                                                                                37
         Mechanism of Action                                                                                                37
         R&D Progress                                                                                                       37
    Sorafenib + Gemcitabine - Drug Profile                                                                                  38
         Product Description                                                                                                38
         Mechanism of Action                                                                                                38
         R&D Progress                                                                                                       38
    Sorafenib + Capecitabine + Oxaliplatin - Drug Profile                                                                   39
         Product Description                                                                                                39
         Mechanism of Action                                                                                                39
         R&D Progress                                                                                                       39
    Bevacizumab + Capecitabine - Drug Profile                                                                               41
         Product Description                                                                                                41
         Mechanism of Action                                                                                                41
         R&D Progress                                                                                                       41
    Aldesleukin + Therapeutic Autologous Lymphocytes + Zoledronic Acid - Drug Profile                                       43
         Product Description                                                                                                43
         Mechanism of Action                                                                                                43
         R&D Progress                                                                                                       44
    Celecoxib - Drug Profile                                                                                                45
         Product Description                                                                                                45
         
								
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