Neuropathic Pain - Pipeline Review, Q1 2011 by GlobalMarketsDirect

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									Neuropathic Pain – Pipeline Review, Q1 2011




                 Neuropathic Pain - Pipeline Review, Q1 2011
                                                                                          Reference Code: GMDHC023IDB

                                                                                          Publication Date: February 2011




Neuropathic Pain – Pipeline Review, Q1 2011                                                                           GMDHC023IDB / Pub FEB 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied
                                                                                                                                         Page(1)
Neuropathic Pain – Pipeline Review, Q1 2011



Ta b le o f Co n te n ts
Table of Contents                                                                                              2
List of Tables                                                                                                 7
List of Figures                                                                                                9
Introduction                                                                                                  11
     Global Markets Direct Report Coverage                                                                    11
Neuropathic Pain Overview                                                                                     12
Therapeutics Development                                                                                      13
     An Overview of Pipeline Products for Neuropathic Pain                                                    13
Neuropathic Pain Therapeutics under Development by Companies                                                  15
Neuropathic Pain Therapeutics under Investigation by Universities/Institutes                                  20
Late Stage Products                                                                                           23
     Comparative Analysis                                                                                     23
Mid Clinical Stage Products                                                                                   24
     Comparative Analysis                                                                                     24
Early Clinical Stage Products                                                                                 25
     Comparative Analysis                                                                                     25
Discovery and Pre-Clinical Stage Products                                                                     26
     Comparative Analysis                                                                                     26
Companies Involved in Neuropathic Pain Therapeutics Development                                               27
     Bristol-Myers Squibb Company                                                                             27
     Johnson & Johnson                                                                                        27
     Kyowa Hakko Kirin Co., Ltd.                                                                              28
     Allergan, Inc.                                                                                           28
     NsGene A/S                                                                                               30
     Sanofi-Aventis                                                                                           30
     AstraZeneca PLC                                                                                          31
     Eli Lilly and Company                                                                                    31
     BioDelivery Sciences International, Inc.                                                                 32
     GlaxoSmithKline plc                                                                                      32
     Nektar Therapeutics                                                                                      34
     Merck & Co., Inc.                                                                                        34
     Dainippon Sumitomo Pharma Co., Ltd.                                                                      35
     Sangamo BioSciences, Inc.                                                                                35
     Infinity Pharmaceuticals, Inc.                                                                           36
     BioLineRx, Ltd.                                                                                          36
     Daewoong Pharmaceutical Co., Ltd.                                                                        37
     Eisai Co., Ltd.                                                                                          37
     Gedeon Richter Plc.                                                                                      38
     Glenmark Pharmaceuticals Ltd.                                                                            38
     King Pharmaceuticals, Inc.                                                                               39
     Meda AB                                                                                                  39
     Pfizer Inc.                                                                                              40
     UCB Group                                                                                                40
     Vernalis plc                                                                                             42
     EpiCept Corporation                                                                                      42
     Evotec Aktiengesellschaft                                                                                43
     GW Pharmaceuticals plc                                                                                   43


Neuropathic Pain – Pipeline Review, Q1 2011                                               GMDHC023IDB / Pub FEB 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                       Page(2)
Neuropathic Pain – Pipeline Review, Q1 2011


     Anavex Life Sciences Corp.                                                                               45
     IntelGenx Technologies Corp.                                                                             45
     AVANIR Pharmaceuticals                                                                                   46
     Lpath, Inc.                                                                                              46
     MediciNova, Inc.                                                                                         47
     Medivir AB                                                                                               47
     NeuroDiscovery Ltd                                                                                       48
     NeurogesX, Inc.                                                                                          48
     NicOx SA                                                                                                 49
     NPS Pharmaceuticals, Inc.                                                                                49
     Pharmos Corporation                                                                                      50
     Adolor Corp.                                                                                             50
     Torrent Pharmaceuticals Limited                                                                          51
     Diamyd Medical AB                                                                                        51
     SCOLR Pharma, Inc.                                                                                       52
     DARA BioSciences, Inc.                                                                                   52
     Proximagen Neuroscience plc.                                                                             53
     Newron Pharmaceuticals S.p.A.                                                                            53
     Raptor Pharmaceuticals Corp.                                                                             55
     Angelini Group                                                                                           55
     Auspex Pharmaceuticals                                                                                   56
     VistaGen Therapeutics , Inc.                                                                             56
     Bionorica AG                                                                                             57
     Snowdon Inc.                                                                                             57
     Neurotune AG                                                                                             58
     Grunenthal GmbH                                                                                          58
     CREABILIS Therapeutics S.r.l.                                                                            59
     Amura Holdings Ltd.                                                                                      59
     Affectis Pharmaceuticals AG                                                                              60
     BioQuest Innovations Inc.                                                                                60
     Grupo Uriach                                                                                             61
     Chlorion Pharma, Inc.                                                                                    61
     PharmEste                                                                                                62
     Solace Pharmaceuticals                                                                                   62
     Rottapharm SpA                                                                                           63
     Hydra Biosciences, Inc.                                                                                  63
     Yaupon Therapeutics, Inc.                                                                                64
     NeurAxon, Inc.                                                                                           64
     Virobay Inc.                                                                                             65
     QRxPharma Limited                                                                                        65
     Cara Therapeutics, Inc.                                                                                  66
     Kalypsys, Inc.                                                                                           66
     Bial Group                                                                                               67
     Krenitsky Pharmaceuticals Inc.                                                                           67
     Lectus Therapeutics Limited                                                                              68
     KAI Pharmaceuticals Inc.                                                                                 68
     Winston Pharmaceuticals, Inc.                                                                            69
     Bial - Portela & Ca, S.A.                                                                                69




Neuropathic Pain – Pipeline Review, Q1 2011                                               GMDHC023IDB / Pub FEB 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                       Page(3)
Neuropathic Pain – Pipeline Review, Q1 2011


     TheraQuest Biosciences, LLC                                                                              70
     Celtic Pharmaceutical Holdings L.P.                                                                      70
     RaQualia Pharma Inc.                                                                                     71
     SK Bio-Pharmaceuticals                                                                                   71
     BUNKER INDUSTRIA FARMACEUTICA LTDA.                                                                      72
Universities/Institutes Involved in Neuropathic Pain Therapeutics Development                                 73
Neuropathic Pain - Therapeutics Assessment                                                                    76
     Assessment by Monotherapy Products                                                                       76
     Assessment by Combination Products                                                                       77
     Assessment by Route of Administration                                                                    78
     Assessment by Molecule Type                                                                              81
Late Stage Drug Profiles – Companies                                                                          83
     BEMA Buprenorphine - Drug Profile                                                                        83
          Product Description                                                                                 83
          Mechanism of Action                                                                                 83
          R&D Progress                                                                                        83
     Dronabinol - Drug Profile                                                                                84
          Product Description                                                                                 84
          Mechanism of Action                                                                                 84
          R&D Progress                                                                                        84
     Lyrica - Drug Profile                                                                                    85
          Product Description                                                                                 85
          Mechanism of Action                                                                                 85
          R&D Progress                                                                                        85
     Sativex - Drug Profile                                                                                   86
          Product Description                                                                                 86
          Mechanism of Action                                                                                 86
          R&D Progress                                                                                        86
     Stedesa - Drug Profile                                                                                   88
          Product Description                                                                                 88
          Mechanism of Action                                                                                 88
          R&D Progress                                                                                        88
     Vitatonus Dexa - Drug Profile                                                                            89
          Product Description                                                                                 89
          Mechanism of Action                                                                                 89
          R&D Progress                                                                                        89
     Zenvia - Drug Profile                                                                                    90
          Product Description                                                                                 90
          Mechanism of Action                                                                                 90
          R&D Progress                                                                                        90
Late Stage Drug Profiles – Universities/Institutes                                                            91
     Amitriptyline - Drug Profile                                                                             91
          Product Description                                                                                 91
          Mechanism of Action                                                                                 91
          R&D Progress                                                                                        91
     Amitriptyline + Ketamine + Lidocaine - Drug Profile                                                      92
          Product Description                                                                                 92
          Mechanism of Action                                                                                 92




Neuropathic Pain – Pipeline Review, Q1 2011                                               GMDHC023IDB / Pub FEB 2011
© Global Markets Direct. This report is a licensed product and is not to be photocopied                       Page(4)
Neuropathic Pain – Pipeline Review, Q1 2011


          R&D Progress                                                                                        92
     Hypothetica - Drug Profile                                                                               93
          Product Description                                                                                 93
          Mechanism of Action                                                                                 93
          R&D Progress                                                                                        93
     ketamine - Drug Profile                                                                                  94
          Product Description                                                                                 94
          Mechanism of Action                                                                                 94
          
								
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