CURRICULUM VITAE
April 2001
NAME: Timothy J. Tewson, Ph.D.
HOME ADDRESS:
18 Forest Glen, Iowa City, Iowa.
BIRTHDATE: October 1, 1946
PLACE OF BIRTH: Bexhill-on-Sea, Sussex, England
CITIZENSHIP: British
UNDERGRADUATE Imperial College, London University
EDUCATION: London, England, 1964-1967
GRADUATE EDUCATION: London University, Ph.D., Organic
Chemistry, 1967-1972
ACADEMIC APPOINTMENTS: Professor
Department of Radiology
University of Iowa Medical School,
University of Iowa, Iowa City 2000-present
Associate Professor,
Department of Radiology,
University of Washington Medical School,
University of Washington, Seattle 1994-2000
Associate Professor
Positron Diagnostic and Research Center, The
University of Texas Health Science Center at
Houston Houston, Texas, 1992 -1994
Associate Professor and Director,
Radiochemistry Section Positron Diagnostic and
Research Center The University of Texas
Health Science Center at Houston Houston, Texas,
1986 - 1992
Research Associate ProfessorDepartment of
Pharmacology The University of Texas Medical
School at Houston Houston, Texas
Assistant Professor and Director Radiochemistry
SectionPositron Diagnostic and Research Center The
University of Texas Health Science Center at
Houston Houston, Texas 1980-1986
Adjunct Professor, School of Pharmacy, University of
Houston Houston, Texas 1983-Present
Assistant Professor of Radiation, Chemistry,
Mallinckrodt Institute of Radiology, Washington
University of School of Medicine St. Louis, Missouri,
1977-1980
Research Fellow, University of Manchester Institute
of Science and Technology Manchester, England,
1974-1977
Research Fellow, School of Molecular Sciences,
University of Sussex Falmer, Sussex, England, 1972-
1974
PROFESSIONAL American Association for the
ORGANIZATIONS: Advancement of Science
American Chemical Society
Society of Nuclear Medicine
American Heart Association
TEACHING RESPONSIBILITIES Sat on 6 PhD committees and have had 4
undergraduates working in the laboratory. Assist in
teaching basic science to the Nuclear Medicine
Residents.
HONORS AND AWARDS: Entrance Scholarship, Imperial
College, 1967
National Research Career
Development Award, 1980
EDITORIAL POSITIONS: Editorial Board, Journal of Nuclear
Medicine 1981-1986.
SERVICE ON NATIONAL Ad hoc Reviewer, National Institute
GRANT REVIEW PANELS, for Neurological Coummunications
STUDY SECTIONS, Disorders and Stroke
COMMITTEES:
Ad hoc Reviewer, Dept. of Energy
Reviewer for DOE Assessment of
Research Projects in the Nuclear
Medicine Research Program 1987
Special Projects NIH Study, Section
June 1988
NCI Site Visit October 1988,
Univ. of Washington, Seattle, WA
NIH Special Radiation Study Section
June 1988, December 1989
NCI Study Section on Brain Tumors
2
and PET November 1990
Site Visit Committee for the
University of Washington Oct 1991,
Seattle
Site Visit to the Medical College of
Wisconsin, MIlwaukee WI, Oct 1991
Reviewer for DOE Assessment of
Research Projects in the Nuclear
Medicine Research Program 1992
Reviewer for NIBIB 2003
Selection Committee for the Society of Nuclear
Medicine Meeting 1987
Selection Committee for Brain 1988, Montreal 1988
Program Sub-Chairman, Society of Nuclear Medicine
Meeting Annual Meeting 1993
Member of the Radiopharmaceutical Science
Council, Society of Nuclear Medicine 1991-1993
Member of the Local Organizing Committee,
Eleventh International Symposium on
Radiopharmaceutical Chemistry 1995.
Member of the Local Organizing Committee,
6th International Workshop on Targetry and Target
Chemistry, 1995
Program Sub-Chairman, Society of Nuclear Medicine
Annual Meeting 1998
SERVICE ON UNIVERSITY Radiation Safety Committee,
OF TEXAS MEDICAL (Chairman 1984-1986)
SCHOOL AT HOUSTON Radioactive Drug Research Committee
COMMITTEES: Risk Awareness committee, 1984-1985
SERVICE ON UNIVERSITY OF Radioactive Drug Research Committee
WASHINGTON COMMITTEES: Faculty Senate
RESEARCH FUNDING: American Heart Association
Grant-in-Aid,
July 1983 to June 1985, T. Tewson Principal
Investigator
National Institutes of Health, RO-I In Vivo
Detection of ß-Adrenergic ReceptorsJuly 1987 to
June 1990. T. Tewson Principal Investigator
3
Upjohn Company. Assement of Carbon-11
Alprazolam (Xanax) as a ligand for the In vivo
Detection of the Benzodiazepine receptor
January 1989 - December 1991, T. Tewson Principal
Investigator
National Institutes of Health, RO-1. Kinetics of
Muscle Metabolism by Positron Tracers.
H.Taegtmeyer PI, 1990-present T. Tewson Co-
Investigator.
Searle. The Labeling and Biodistribution of
LomefloxacinJanuary 1992 to Present. T. Tewson
Principal Investigator
National Instututes of Health,
Use of PET to Study the Effects of
Thermochemotherapy.1990-1995 JMC Bull PI,
T.Tewson Co-Investigator.
National Institutes of Health RO-1. Temporal
Hetrogeneity of Lung Perfusion and Ventilation. ER
Swenson PI T. Tewson Co-investigator
National Institutes of Health RO-1. In Vivo Detection
of -Adrenergic Receptors. July 1996-June 1999. T.
Tewson Principal Investigator
Royalty Research Fund. The evaluation of F-18
fluoro t-butylnitrone as an agent for in vivo imaging
of oxygen radicals. July 1996-June 1997 T. Tewson
Principal Investigator.
National Cancer Institute. PO-1 Metabolic Imaging of
Cancer and Its Response to Therapy. Years 11-15.
Ken Krohn PI T. Tewson Co-investigator.
National Institutes of Health RO-1 Sub-Type
Selective Ligands for the -Adrenoreceptor. March
1998-Feb 2001. T. Tewson Principal Investigator
4
PUBLICATIONS
MANUSCRIPTS IN REFEREED JOURNALS
1. Anger, I.R., Tewson, T.J., Phillips, L., Wray, V.: 19F Nuclear magnetic resonance
studies of aromatic compounds. Part II. The 19F chemical shifts in meta- and para-
substituted flurobenzens, and 4-substituted 3'-4'-fluoro-trans-stillbenes. J.C.S. Perkins
Trans. II:1979-1983, 1972.
2. Barton, D.H.R., Hesse, R.H., Pechet, M.M., Tewson, T.J.: Synthesis of 12-fluoro-
corticosteroids. J.C.S. Perkins Trans. I: 2395-2401, 1973.
3. Taylor, R., Tewson, T.J.: Concerning the -complex mechanism for aromatic
substitution. Detritiation in trifluoromethane sulphonic acid. J.C.S. Chem. Comm.
836-837, 1973.
4. Tewson, T.J.: Bistrifluoromethylhydroxylamine-O-trifluoromethane sulphonate.
Nucleophilic attach on nitrogen. J. Fluorine Chem. 101-108, 1976.
5. Tewson, T.J., Welch, M.J.: New approaches to the synthesis of 3-deoxy-3-fluoro-D-
glucose. J. Org. Chem. 43:1090-1094, 1978.
6. Tewson, T.J., Welch, M.J., Raichile, M.E.: 18F-labeled 3-deoxy-3-fluoro-glucose:
Synthesis and preliminary biodistribution data. J. Nucl. Med. 19:2339-2346.
7. Bergman, S.R., Hack, S.N., Tewson, T.J., Welch, M.J., Sobel, B.E.: The dependence
of accumulation of 13NH3 by myocardium on metabolic factors and its implications
for quantitative assessment of perfusion. Curc. 61:34-42, 1980.
8. Tewson, T.J., Welch, M.J.: "No carrier added" 18F-fluoroethanol, synthesis and
preliminary biodistribution. J. Nucl. Med., 21:559-568, 1980.
9. Tewson, T.J., Welch, M.J., Raichle, M.E.: Preliminary studies with 18F-Haloperidol: a
radioligand for in vivo studies of the dopamine receptor. Brain Res. 192:291-295,
1980.
10. Tewson, T.J., Welch, M.J., Raichle, M.E.: Preparation of fluorine-18 aryl fluoride:
piperidyl triazenes as a source of diazonium salts. J.C.S. Chem. Com., 1149-1151,
1979.
11. Tewson, T.J., Maeda, M., Welch, M.J.: Preparation of no carrier added 18F-aryl
fluorides: conditions and scope of reaction. J. Lab Cmpds. Radiopharm., 18:21, 1981.
12. Maeda, M., Tewson, T.J., Welch, M.J.: Preparation of no carrier added 18F-
spiroperidol. J. Lab. Cmpds. Radiopharm., 18:192, 1981.
13. Berridge, M., Tewson, T.J., Welch, M.J.: Preparation of 18F-7-fluoropalmitic acid. J.
Lab. Cmpds. Radiopharm., 18:102, 1981.
14. Tewson, T.J., Cyclic sulphur esters as substrates for nucleophillic substitution. J. Org.
Chem. 48:3507-3570, 1983.
5
15. Tewson, T.J.: Synthesis of no carrier added fluorine-18 2-deoxy-2-fluoro-glucose. J.
Nucl. Med. 24:718-821, 1983.
16. Kilbourn, M.R., Welch, M.J., Dence, C.S, Tewson, T.J., Saji, H., Maeda, M.: Carrier
added and no carrier added synthesis of [18F] spiroperidol and [18F] haloperidol. Int.
J. Appl. Radiat. and Isotopes 35:591-598, 1984.
17. Berridge, M., Rosenfeld, E., Tewson, T.J.: Cyclic sulfates as substrates for
nucleophilic substitution. Fifth International Symposium on Radiopharmaceutical
Chemistry, J. Lab. Cmpds. Radiopharm. 21: 1184-5 1984
18. Tewson, T.J., Soderlind, M.: 1-Propenyl-4,6-benzylidene ß-mannopyranoside-2,3-
cyclic sulfate: A substrate for the synthesis of F-18-2-deoxy-2-fluoro-glucose. J.
Carbohydrate Chem. 4:529-541, 1985.
19. Berridge, M.S., Tewson, T.J.: Effects of target design on the production and utilization
of [F-18]-fluoride from [0-18]-water. J. Lab. Cmpds. Radiopharm. 23 117-9, 1986.
20. Tewson, T.J., Berridge, M.S., Soderlind, M., Vaidya, M.: Labelled ligands for the in
vivo measurement of the beta adrenergic receptor. J. Lab. Cmpds. Radiopharm. 23
1412, 1986
21. Gould, K.L., Goldstein, R.A., Mullani, N.A., Kirkeeide, R.L., Wong, W.H., Tewson,
T.J., Berridge, M.S., Bolomey, L.A., Hartz, R.K., Smalling, R.W., et al: Noninvasive
assessment of coronary stenoses by myocardial perfusion imaging during
pharmacologic coronary vasodilation. VIII. Clinical feasibility of positron cardiac
imaging without a cyclotron using generator-produced rubidium-82. J. Am. Coll.
Cardiol. 7(4). P 775-89 1986.
22. Berridge, M.S., Franceschini, M.P., Tewson, T.J., Gould, K.L.: Preparation of oxygen-
15 butanol for positron tomography. J. Nucl. Med. 27:834-8, 1986.
23. Berridge, M.S., Tewson, T.J.: Chemistry of fluorine-18. Int. J. Appl. Radiat. Isotopes
37:6850-693, 1986.
24. Tewson, T.J., Berridge, M.S., Bolomey, L., Gould, K.L.: Effects of target design on
the production of [F-18] fluoride from oxygen-18 water. Int. J. Appl. Radiat. Isot.
15:49-504, 1988.
25. Bank, W., Tewson, T.J., Digenis, G.: Synthesis of Carbon-11 Alprazolam. A
Diazepam Receptor Agonist. J. Lab. Cmpds. Radiopharm. 26: 69-71, 1989
26. Tewson, T.J., Banks, W., Franceschini, M.P., Hoffpauir, J.: A trap for the removal of
oxides of nitrogen from Carbon-11 Carbon Dioxide. Appl. Radiat. Isot. 40:765-768,
1989.
27. Mossberg, K.A., Rowe, R.W., Tewson, T.J., and Taegtmeyer, H.: Rabbit hindlimb
glucose uptake assessed with positron emitting fluorodeoxyglucose. J. Appl. Physiol.
67:1569-77, 1989
28. Tewson, T.J.: Procedures, Pitfalls and Solutions in the Production of [F-18]-2-Deoxy-
2-Fluoro-D-glucose: A Paradigm in the Routine Synthesis of Fluorine-18
Radiopharmaceuticals, J. Nucl. Med. and Biol. 16:533-561, 1989.
6
29. Banks, W.R., Dignneis, G.A., Tewson, T.J., Smith, R., and Fleishaker, J.: 1-[11C]-
Alprazolam: A receptor Agonist for In Vivo Studies of the Benzodiazepine Receptor.
Appl. Radiat. Isot. 41:719-726, 1990.
30. Berridge, M.S., Rosenfeld, P., Franceschini, M.P., Tewson, T.J.: Cyclic sulfates as
substrates for nucleophilic substitution: scope and limitations of the substitution
reaction. J. Org. Chem. 55:1211-1216, 1990.
31. Overturf, M., Smith, S., Gotta, A., Marrsett, J., Tewson, T.J., Pooman, J., and Loose-
Mitchell, D.: Dietary Cholesterol Absorption, and Sterol and Bile Acid Excretion in
Hypercholesterolimia-Resistant White Rabbits. J. Lipid Research 31:2019-2027,
1990.
32. Nguyen, V.T.B., Mossberg, K.A., Tewson, T.J., Wong, W.H., Rowe, R.W., Coleman,
G.M., and Taegtmeyer, H.: Assessment of myocardial glucose metabolism by 18-F-2-
deoxy-2-fluoro-D- glucose: Effects of work load, competing substrates and insulin.
Am. J. Physiology, Heart and Circulatory Physiology H1022-1032 1990.
33. Tewson, T.J., Kinsey, B.M., and Franceschini, M.P.: Synthesis of Fluorine-18
fluoroalkyl pindolol derivatives: Ligands for the -adrenergic receptor. J. Lab. Cmpds.
Radiopharm. 30: 385-386 1991
34. Kinsey, B.M. and Tewson, T.J.: Fluorine-18 fluoroalkyl derivatives of carazalol:
potential ligands for the In Vivo studies of the -adrenergic receptor. J. Lab. Cmpds.
Radiopharm. 30: 373-4 1991
35. Dobbs, F.R., Banks, W.A., Fleishaker, J.C., Digenis, G.A., and Tewson, T.J.: The
routine synthesis of carbon-11 alprazolam utilizing carbon-11 acetyl chloride as a
synthetic intermediate. J. Lab. Cmpds. Radiopharm. 30: 230-233 1991
36. Tewson, T.J., Franceschini, M., Scheule, R., Holian, A.: Labelling of Asbestos Fibres.
Appl. Radiat. Isot. 42 499-504 1991.
37. Michael Merhige, Dahlia Garza, David Sease, R. Wanda Rowe, Timothy Tewson, Ali
Emran, Leonard Bolomey and K. Lance Gould. Quantitation of the Critically Ischemic
Zone at Risk During Acute Conorary Artery Occlusion Using PET. J. Nucl. Med. 1991
32: 1581-1586
38. Yang, D.J., Tewson T.J., Tansey, W., Li-Ren, Yuang, Regger, G., Cherif, A., Wright,
K.C., Moult, R.G., Tilbury R.S., , Wallace, S.: Halogenated Analogs of Tamoxifen:
Synthesis, Receptor Assay and Inhibition of MCF7 Cells J. Pharm. Sci. 81 622-625
1992
39. Tewson T.J. Synthesis Fluorine-18 Lomefloxacin, A fluorinated quinoline antibiotic. J.
Lab. Cmpds. Radiopharm. 32; 145-146 1993
40. Kinsey B.M., Barber R. Tewson T.J., Synthesis of Fluorine-18 Fluorocarazolol: A
ligand for the -adrenergic receptor. J. Lab. Cmpds. Radiopharm. 32: 298-299 1993.
41. Kinsey B.M. Tewson T.J. Synthesis of No Carrier Added Fluorine-18 Fluoroacetone, a
useful Synthetic Intermediate. J. Lab. Cmpds. Radiopharm. 32:300-302 1993.
7
42. Dobbs F.R., Franceschini M.P., Tewson T.J The Routine Synthesis of Carbon-11
Phosgene, An Intermediate to Carbon-11 2-Thymine. J. Lab. Cmpds. Radiopharm. 32:
191-193 1993
43. Tewson T.J., Fleishaker J.C., Dobbs F,Banks W, Digenis G.A., PET Studies with 11C
- Alprazolam; An Agonist for the Benzodiazepine Receptor J. Nucl. Med and Biol. 22
459-466 1995
44. Tewson, K. Sadilkova, C. Supuran and E Swenson The Synthesis Of Fluorine-18
Labeled Carbonic Anhydrase IV Inhibitors: Selectivity By Exclusion. J. Lab. Cmpds
and Radiopharm. 37 237-239 1995.
45. Tewson T.J. The Routine Synthesis Of Fluorine-18 16-Fluoroestradiol: The Use Of
3-Methoxymethyl-Epiestriol-16,17-Cyclic Sulfate As The Starting Substrate. J. Lab.
Cmpds and Radiopharm. 37 589-591 1995
46. Tewson T.J., D.Yang, G.Wong, D. Macy, O.J.DeJesus, R.J. Nickles, S.B. Perlman, M.
Taylor, P. Frank. The Synthesis of Fluorine-18 Lomefloxacin and its Preliminary Use in
Human Studies J. Nucl. Med. and Biol. 23 767-772, 1996.
47. Lim J.L., Lei Zheng, M.S. Berridge, and T.J. Tewson. The use of 3-methoxymethyl-
16,17-epiestriol-O-cyclic sulfone as the precursor in the synthesis of F-18 16-
fluoroestradiol. J. Nucl. Med. and Biol. 23 911-915, 1996.
48. Mankoff D.M., Tewson T. J. Eary J.F. Analysis of the Blood Clearance and
Metabolism for the Estrogen Receptor Tracer, [F-18] 16-Fluoroestradiol (FES). J.
Nucl. Med. and Biol. 24 341-348 1997.
49. T. J. Tewson. Synthesis of F-18 Fluoroetanidazole: a Potential New Tracer for Imaging
Hypoxia. J. Nucl. Med. and Biol. 24 755-760 1997
50. T. J. Tewson. Synthesis of [F-18]-Fluoroetanidazole - A New Nitroimidazole Tracer of
Hypoxia. J. Lab. Cmpds. and Radiopharm. 40 56-57 1997
51. T. J. Tewson, Svetlana Stekhova. Synthesis of the Stereoisomers of [F-18]-
Fluoropropanolol, a Tracer for the -Adrenergic Receptor. J. Lab. Cmpds. and
Radiopharm.40 58-59 1997.
52. T. J. Tewson, Eric G. Shankland, Margaret T. Tewson, Akana Wada, Linda Weins, and
Kenneth A. Krohn. N,N-Dimethyl-3-mercapto-4,4,4-trifluorobutylamine; A Potential
Agent for the NMR Measurement of the Cytosolic Redox State. J. Med. Chem.
Submitted.
53. T. J. Tewson and K. A. Krohn, PET Radiopharmaceuticals: State of the Art and Future
Prospects. Seminars in Nuclear Medicine. 28 221-234 1998.
54. Janet S. Rasey, Phillip D. Hofstrand, Lay K. Chin and Timothy J. Tewson.
Charaterization of [F-18]Fluoroetanidazole, a New Radiopharmaceutical for Detecting
Tumor Hypoxia. J. Nucl. Med. 40 1072-1079 1999.
55. Timothy J. Tewson, Svetlana Stekhova, Berma Kinsey, Lay Chin, Linda Wiens and
Roger Barber. Synthesis and Biodistribution of the stereoisomers of [F-18]-
Fluoropropanolol, a Tracer for the -Adrenergic Receptor. Nucl. Med. and Biol. 26
891-896, 1999
8
56. Tewson T. J. Mankoff D. A. Peterson L.M, Woo I., and Petra P. The Interactions of
16-[18F]-Fluoroestradiol (FES) with Sex Steroid Binding Protein (SBP). Nucl. Med.
and Biol. 26 905-913 1999
57. Tewson T. J. Enzyme Inhibition as an Aid to Simplify Pharmacokinetic Measurments.
J. Nucl. Med. 41 1725-26 2000
58. David A. Mankoff, Lanell M. Peterson, Timothy J. Tewson, Jeanne M. Link, Julie R.
Gralow, Michael M. Graham, Kenneth A. Krohn, [F-18]Fluoroestradiol Radiation
Dosimetry in Human PET Imaging Studies. J. Nucl. Med. 42 679-684 2001
59. Swenson ER. Tewson TJ. Wistrand PJ. Ridderstrale Y. Tu C. Biochemical,
histological, and inhibitor studies of membrane carbonic anhydrase in frog gastric acid
secretion. American Journal of Physiology - Gastrointestinal & Liver Physiology.
281:G61-8, 2001.
60. P. Doze, A. van Waarde, T.J. Tewson W. Vaalburg, P.H. Elsinga. Synthesis and
evaluation of (S)-[18F]-fluoroethylcarazolol for in vivo beta-adrenoceptor imaging in
the brain. Neurochemistry International 41 17-27 2002.
61. Jeffrey J. Posakony John R. Grierson Timothy J. Tewson.New Routes to N-Alkylated
Cyclic Sulfamidates. J. Org. Chem., 67 (15), 5164 -5169, 2002
62. Jeffrey J. Posakony, Timothy J. Tewson. Substitution Reactions of Hindered Cyclic
Sulfamidates. Synthesis 859-864 2002
63. Jeffrey J. Posakony. Timothy J. Tewson. Fluoroamines via Chiral and Hindered Cyclic
Sulfamidates. Synthesis 766-770 2002
64. T. J. Tewson. Labeled Antibiotics: Positron Tomography as a Tool for Measuring
Tissue Distribution. Drug Development Research 59: 261-268 2003
9
CHAPTERS
1. Tewson, T.J.: Aromatic compounds. In: The Annual Reports of the Chemical Society,
P.G. Sammes (ed). Vol. B, ch. 11. The Chemical Society, 1974.
2. Welch, M.J., Whittmer, S.L., Dence, C.S., Tewson, T.J.: Radiopharmaceuticals
labelled with 11C and 18F: considerations related to the preparation of C-11 palmitate.
In: Short Lived Radionuclides in Chemistry and Biology, Root and Krohn (eds)
Advances in Chemistry Series 197, American Chemical Society, Washington, D.C.,
chapter 21, 407, 1981.
3. Welch, M.J., Tewson, T.J.: Production of high specific activity compounds with short
lived radionuclides. In: Receptor Binding Radiotracers. W.C. Eckleman (ed.), C.R.C.
Press, Boca Raton, Florida, p. 55, 1982.
OTHER PROFESSIONAL COMMUNICATIONS
1. Tewson, T.J., Welch, M.J.: Concerning the terminology of radiopharmaceuticals. J.
Nucl. Med. 22:392, 1981.
2. Tewson, T.J.: Radiopharmaceuticals - structure - activity relationships. J. Nucl. Med.
23:367, 1982.
3. Tewson, T.J.: (Teaching Editorial) Radiopharmaceuticals for receptor imaging. J.
Nucl. Med. 24:442-443, 1983.
4. Tewson, T.J.: Re Radiopharmaceuticals for receptor imaging. J. Nucl. Med. 25:534,
1984.
5. Tewson, T.J.: Chemistry for nuclear medicine. J. Nucl. Med. 24:753, 1983.
6. Tewson T.J: Fluorine-18 Labeling of Radiopharmaceuticals. J. Nucl. Med. and Biol.
32:2197 1991
ABSTRACTS
1. Tewson, T.J., Welch, M.J., Raichle, M.E.: Synthesis and animal distribution studies of
18F-3-deoxy-3-fluoro-D-glucose. Presented at the Second International Symposium
on Radiopharmaceutical Chemistry, St. Catherine's College, Oxford, England, p. 10,
1978.
2. Klein, M.S., Goldstein, R.A., Tewson, T.J., Welch, M.J., Sobel, B.E.: Non-invasive
quantification of myocardial metabolism with intravenous and intra-atrial injection of
C-11 palmitate. Presented at the 29th Annual Meeting of the American College of
Cardiology, Miami Beach, 1979.
3. Bergman, S.R., Hack, S.N., Tewson, T.J., Welch, M.J., Sobel, B.E.: Limitations in the
use of 13NH3 for measurement of myocardial perfusion. Presented at the American
Society for Clinical Investigation, Washington, D.C. 1979.
10
4. Tewson, T.J., Welch, M.J.: Synthesis of carrier-free fluorine-18 fluoroethanol. J.
Nucl. Med. 20:663, 1979.
5. Tewson, T.J., Welch, M.J.: Synthesis of carrier-free fluorine-18 labelled aromatic
compounds and its application to the preparation of fluorine-18 labeled neuroleptic
haloperidol. J. Nucl. Med. 20:671, 1979.
6. Tewson, T.J., Welch, M.J., Raichle, M.E.: Synthesis of F-18-3-fluoro-D-glucose.
Presented at the Second International Congress of the World Federation of Nuclear
Medicine and Biology, Washington, D.C., 1978.
7. Tewson, T.J.: Synthesis of positron emitting radiopharmaceuticals. Proceeding of the
34th Annual Conference on Engineering in Medicine and Biology, 32:3, 1981.
8. Tewson, T.J., Gould, K.L.: Synthesis of 2-deoxy-2-fluoro-glucose using fluoride ion as
a source of fluorine. J. Nucl. Med.23:109, 1982.
9. Tewson, T.J.: An alternative synthesis of 2-deoxy-2-fluoro-glucose. Fourth
International Symposium of Radiopharmaceutical Chemistry. Julich, West Germany
1982.
10. Gateley, S.J., Hutchins, P., Tewson, T .J., Nickles, J.: Reaction of electrophilic and
nucleophilic fluorine. Amer. Chem. Society, 1983.
11. Tewson, T.J.: Synthesis of 16-Fluoroestradiol. Society of Nuclear Medicine
Meeting, St. Louis, June 1983.
12. Tewson, T.J., Soderlind, M.: 1-propenyl-4,6-0-benzylidene-ß-mannopyranoside: A
new substrate for the synthesis of [F-18]-2-deoxy-2-fluoroglucose. J. Nucl. Med.
26:129, 1985.
13. Holden, J.E., Tewson, T.J., Degrado, T.R., Ng, C.K., Raffel, D.M.: Quantitative assay
of free beta adrenergic density in perfused rat heart. J. Nucl. Med. 27: 949, 1986.
14. Tewson, T.J., and Berridge, M.S.: In vivo biodistribution and competitive binding of I-
125 Iodocynaopindolol. J. Nucl. Med. 27:291, 1986.
15. Izumiyama, M., Kogure, K., Lockwood, A.H., Yap E., Tewson, T.J., IX-P05: An
Autoradiographic measurement of local hematocrit in the early phase of cerebral
ischemia. J. Cerebral Blood Flow and Metabolism 7: suppl. 1, 1987.
16. Masahiro Izumiyam, Kyuya Kogure, Alan H. Lockwood, Eddy W.H. Yap, and T.J.
Tewson Penetration of red blood cells into the ischemic boundary in the early phase of
cerebral embolism. Proceeding of the Satellite Symposium, Brain Section, Fourth
World Congress for Microcirculation, Oska, Japan, August 1987.
17. Izumiyama, M., Kogure, K. Lockwood, A.H., Tewson, T.J., Yap, E.W.H., Labove,
J.Y.: Measurement of local oxygen metabolism in postischemic rat brain by 1502
equilibration. 40th Meeting of AAN Scientific Program Abstract Form, Cincinnati
Ohio, April, 1988.
18. Digenis, G., Banks, W., Tewson, T.J.: Receptor level pharmacokinetics in man
utilizing Carbon-11 Labeled Alprazolam, A Benzodiazepine Receptor Agonist.
11
International Conference on Pharmaceutical Sciences and Clinical Pharmacology.
Jerusalem, Israel, May, 1988.
19. Mossberg, K.A., Marani, S., Tewson, T.J., Taegtmeyer, H.: Rapid Kinetic Assessment
of Skeletal Muscle Glucose Uptake by the Rabbit Hindlimb In Vivo. Clinical Research
36, 486A, 1988.
20. Tewson, T.J., Franceschini, M.P., Hoffpauir, J.: A Trap For Removing Oxides of
Nitrogen from Carbon-11 Carbon Dioxide. Presented at the Society of Nuclear
Medicine, San Francisco, June, 1988.
21. Rowe, R.W., Bull, J.M.C., Taegtmeyer, H., Tewson, T.J., Raval, B., Swanson, W.,
Crews, L., Patel, D., and Cheng, M.: Assessment of early tumor response to therapy by
metabolic imaging with positron emission tomography. J. Nucl. Med., 30(5)
suppl:789, 1989.
22. Tewson, T.J.: Organic synthesis with high specific activity fluorine-18. American
Chemical Society, Dallas, April, 1989.
23. Tewson, T.J., Franceschini, M., Gillum, K., Kinsey, B., Tilbury, R., Berridge, M.S.:
The synthesis of 1-[C-11] pyruvic acid. Society of Nuclear Medicine, St. Louis,
Missouri, June, 1989.
24. Rowe, R.W., Tewson, T.J., Bull, J.M.C., Schneider, C., and Sen, M.L.: Positron
emission tomographic (PET) measurement of early changes in metabolic activity of
liver metastases following therapy. Presented at 1990 Biomedical Engineering
Research in Houston Conference, Houston, February, 1990.
25. Bull, J.M.C., Rowe, R.W., Tewson, T.J., Raval, B., and Taegtmeyer, H.: Measurement
by positron emission tomography (PET) of thermo- (TC) and chemotherapy (CHEM)
induced metabolic response of colon liver metastases (METS). Presented at 1990
Radiation Research Society/North American Hyperthermia Group annual meeting,
New Orleans, April, 1990.
26. Tewson, T.J., Kinsey, B.M., and Franceschini, M.P.: Imaging the ß-adrenergic receptor
I: [F-18]-fluoroalkyl derivatives of pindolol. American Chemical Society, Boston,
April, 1990.
27. Kinsey, B.M. and Tewson, T.J.: Imaging the ß-adrenergic receptor II: [F-18]-
fluoroalkyl derivatives of carazolol. American Chemical Society, Boston, April, 1990.
28. Schneider, C.A., Bull, J.M.C., Rowe, R.W., Tewson, T.J., Raval, B., and Taegtmeyer,
H.: Positron emission tomography with [18F]-2-deoxy-2-fluoro-glucose: a sensitive
and specific non-invasive tool for monitoring metabolic changes in tumor metastases in
response to therapy. 1990 American Federation for Clinical Research annual meeting,
May, 1990.
29. Bull, J.M.C., Rowe, R.W., Tewson, T.J., Raval, B., and Taegtmeyer, H.: Therapuetic
response assessed by non-invasive measurement of early metabolic change in colon
cancer liver metastases. 1990 American Society of Clinical Oncology annual meeting,
May 20-22, 1990.
12
30. Tewson, T.J. and Kinsey, B.M. Barber, R.: Fluorine-18 ligands for the In Vivo study
of the ß-adrenergic receptor in the heart and lung. American Chemical Society,
Washington, D.C.,August, 1990.
31. T.J. Tewson, M.P. Francsechini, R.K. Scheule and M.A. Holian. Binding of
Radiolabeled Asbestos Fibres to Guinea Pig Alveolar Macrophages. Meeting of the
Society of Toxicology Dallas Texas March 1991.
32. Dobbs, J. Fleishaker, G. Digennis, T.J. Tewson, In Vivo Studies of the Cerbral Uptake
and Retention of Carbon-11 Alprazolam, a Benzodiazepine Receptor Agonist, Using
PET. 38th Annual Meeting of the Society of Nuclear Medicine, Cincinatti Ohio. 1991.
J. Nucl. Med. 32 1009 1991
33. Lim, M.S. Berridge and T. J. Tewson. Preparation of [18F]16-Fluoro-17-Estradiol by
Selective Nucleophilic Substitution. J. Lab. Cmpds. Radiopharm. 35, 176-177 1994.
34. T.J. Tewson, D. Yang, G. Wong, D. Macy, O. J. DeJesus, R. J. Nickles, S. B. Perlman,
M. Taylor, P. Frank. 18F-Lomefloxacin: Human In Vivo Pharmacokinetic Studies
Using Fluorine-18 Labelled Drugs Tenth International Symposium on
Radiopharmaceutical Chemistry, Kyoto, October 1992
35. Kenneth Krohn, Timothy J. Tewson and Janet Rasey, Imaging Nitroimidazoles as a
measure of O2 : Methods from PET, SPECT and NMR. Presented at the 210th
Americain Chemical Society National Meeeting, Chicago IL, August 20-24th, Abstract
NUCL 069.
36. Krohn, J.R. Grierson, J.M. Link, T. J. Tewson, J. F. Eary. Radiopharmaceuticals for
PET in Oncology: matching the chemical to biology to answer a clinical question.
Metabolic Imaging of Cancer, the European Confrence on Research and Application of
Positron Emission Tomography. April 1996
37. Tewson T.J. Mankoff D.A. Eary J.F. Positron Emission Tomography (PET) and [F-18]
16-fluoro-estradiol (FES) to assess breast cancer estrogen receptor content. National
Meeting of the Americain Association of Cancer Research, San Diego 1997
38. T.J.Tewson The synthesis of [F-18]-fluoroetanidazole: a potential new tracer for
measuring hypoxia. J. Nucl. Med. 38 43P 1997
39. . T. J. Tewson, D. A. Mankoff, J. F. Eary. Metabolism And Clearance Of [F-18] 16-
Fluoroestradiol (FES) In Patients 38 176P 1997
40. Janet S. Rasey, Phillip Hofstrand, Lay Chin, Ziping Yang and Timothy J. Tewson [F-
18]-Fluoroetanidazole, A New Tracer for Detecting Hypoxic Cells. Radiation
Research Society April 25th-29th 1998.
41. TJ Tewson, DA Mankoff, P. Petra, I Woo, LM Peterson. [F-18]-Fluoroestradiol [FES]:
Binding to Sex Steroid Binding Protein (SBP). J. Nucl. Med. 39 35P 1998.
42. J S. Rasey, P.D. Hofstrand, L. K. Chin, Z. Yang and T. J.. Tewson [F-18]-
Fluoroetanidazole, A New Tracer for Quantifying Hypoxia. 39 35P 1998.
43. T.J. Tewson, S. Stekhova and E. Swenson. The synthesis and preliminary evaluation of
[F-18]-N-p-fluorobenzyl-aminobenzolamide, an inhibitor of carbonic anhydrase IV.
13
The 13th International Symposium on Radiopharmaceutical Chemistry St. Louis MO
June 26th-July 1st 1999.
44. J.J. Posakany and T. J. Tewson. Progress in the synthesis of [18-F]-Fluoroamines;
Precursors to -selective adrenergic receptor ligands. The 13th International
Symposium on Radiopharmaceutical Chemistry St. Louis June MO 26th-July 1st 1999.
45. T. J. Tewson, S. Stekhova, L. Wiens, L. Chen, R. Barber. Synthesis and preliminary
evaluation of S and R fluoropropranolol, a lipophillic ligand for the -adrenergic
receptor 46th Annual Meeting of the Society of Nuclear Medicine, Los Angeles CA
June 6th-10th 1999.
1 2 1 2
46. T. J. Tewson, L. Zheng, K. M. Seymour, L. Wiens, J. H. Caldwell. Studies of
lipophillic fluorine-18 labeled b-adrenergic receptor ligands in the isolated rat heart:
Evidence for two binding sites. 46th Annual Meeting of the Society of Nuclear
Medicine, Los Angeles CA June 6th-10th 1999.
47. D. A. Mankoff T. J. Tewson, L. M. Peterson, S. Stekhova, J. R. Gralow, R. B.
Livingston, R. E. Moe, The Heterogeneity Of Estrogen Receptor (ER) Expression In
Metastatic Breast Cancer As Measured By [18F]-Fluoroestradiol (FES) PET. 47th
Annual Meeting of the Society of Nuclear Medicine, June 3-7th St. Louis MO. 2000
48. P. Doze*, P. H. Elsinga, A. van Waarde, T. J. Tewson, W. Vaalburg, [18F]-Fluoro-
ethylcarazolol; a Potent Radioligand for Imaging of Beta-adrenoceptors in the Brain
with PET. 47th Annual Meeting of the Society of Nuclear Medicine, June 3-7th St.
Louis MO. 2000
49. David Mankoff, Lanell Peterson, Tim Tewson, Svetlana Stekhova, Kenneth Krohn,
Non-invasive PET Imaging of ER Expression in Breast Cancer: Sex Steroid Binding
Protein (SBP or SHBG) Interaction and ER Expression Heterogeneity. 2001 AACR
Annual Meeting in New Orleans, LA
50. J.J. Posakany and T. J. Tewson. Progress in the synthesis of [18F]-Fluoroamines;
Precursors to -selective adrenergic receptor ligands. The 13th International
Symposium on Radiopharmaceutical Chemistry St. Louis June MO 26th-July 1st 1999.
51. J.J. Posakony and T.J. Tewson. The Synthesis and Characterization of [18F]-labeled
Fluoroamines. The 14th International Symposium on Radiopharmaceutical Chemistry,
Interlaken June 10th-15th, 2001
52. J.J. Posakony and T.J. Tewson. [18F]-Labeled 1-Selective Ligands For Imaging The
Adrendergic Receptors Of The Heart. The 14th International Symposium on
Radiopharmaceutical Chemistry, Interlaken June 10th-15th, 2001
53. Timothy Tewson, G. Leonard Watkins, Tweaking the FLT Synthesis: Modifications
that Improve the Yield. The Annual Meeting of the Society of Nucler Medicine 2001.
54. Timothy Tewson, Andrew Paulsen and Faiza el-Shafie. Production of F-18
fluorothymidine: substrates and yields. The 15th International Symposium on
14
Radiopharmaceutical Chemistry, Sydney, Australia, August 2003 (J. Lab. Cmpds.
Radiopharm. 46 S222 2003
55. DA Mankoff, LM Peterson, PH. Petra, S Stekhova, JR Gralow, RB Livingston, EK
Schubert, TJ Tewson, KA Krohn. Factors Affecting the Level and Heterogeneity of
Uptake of [F-18]-fluoroestradiol (FES) in Patients with Estrogen Receptor-Positive
(ER+) Breast Cancer J. Nucl.. Med.43 286P 2002
NATIONAL INVITATIONAL LECTURES
Welch, M.J., Tewson, T.J.: Radiopharmaceuticals for neurological studies.
Radiopharmaceuticals II, Society of Nuclear Medicine, New York, 1980.
Tewson, T.J.: Preparation and use of high specific activity fluorine-18 fluoride. D.O.E.
symposium on receptor binding radiopharmaceuticals. Las Vegas, 1985.
Tewson, T.J.: Dynamic characteristics of labelled ß-adrenergic receptor ligands. 1986
Society of Nuclear Medicine Winter Meeting, West Palm Beach, Florida.
Tewson, T.J.: Preparation of High specific activity Fluorine-18 Fluoride. American
Chemical Society, Dallas 1989.
15