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School of Life Sciences - Edinburgh Napier University

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					Role Description

Grade & Salary:         Grade 5 £28839 - £34435 p.a.

Location:               School of Life Sciences, Merchiston

Responsible to:         Prof Vicki Stone

Responsible for:        Delivering the research objectives of the EC FP7 project InLiveTox

Role Summary:           Postdoctoral research fellow working primarily at Napier University and
                        for short periods at PIsa
                        To deliver the toxicology work required for the project InLiveTox
                        according to the Description of Work agreed by the EC and project
                        partners.


Main Duties and Responsibilities

     Assessment of the toxicology of a panel of nanoparticles using a range of cell lines in vitro
      (Gastrointestinal tract, endothelial cells and liver).

     To incorporate these cells into a microfluidics model (designed by CSEM and Pisa) and
      assess their viabilty and function.

     To provide feedback on the suitability of the microfluidics system to Pisa.

     To assess the toxicity of nanoparticles to the cells in the microfluidics model and to relate
      this to the data generated in vitro and in vivo.

     To integrate and promote knowledge transfer between workers at the participating
      institutions in order to strenghthen the network of experts and promote further studies.

     To present data at local, national and international meetings
Nanoparticle Toxicology – development of an in vitro tool

European Commission FP7 funded Postdoctoral Research Fellow (full time 36
months)
School of Life Sciences, Edinburgh Napier University (Prof Vicki Stone)
In Collaboration with:
     Centre Suisse d'Electronique et de Microtechnique, Switzerland
     Universities of Pisa, Italy
     Saarland University, Germany
     Helmholtz Zentrum München, Germany
     Kirkstall Ltd, UK
     University of Rochester, USA
     ALMA Consulting Group, France

Nanotechnology is rapidly expanding resulting in the development of many
nanomaterials for incorporation into a wide range of consumer products including
food, food packaging, health remedies and medicines. This project, InLiveTox,
funded by European Commission, will use an interdisciplinary consortium to develop
an improved in vitro microfluidics model for the study of nanoparticle (NP) uptake,
transport and cellular interactions. InLiveTox will focus on the impact of NP
exposure via ingestion, in the healthy and diseased gastrointestinal tract,
endothelium and liver. The key questions pertaining to this research are: (i) How do
these tissues individually respond to NP? (ii) How do the interactions between these
different tissues modulate their individual responses? (iii) How does inflammation
affect the toxicity of NP and their ability cross the intestinal barrier? (iv) Which
physico-chemical characteristics of NP influence their uptake by intestinal epithelial
cells and their subsequent interactions with the vascular endothelium and liver cells?

Applications are invited for a postdoctoral research fellow to work primarily at
Edinburgh Napier University, Edinburgh, but also at Pisa. You should be educated
to PhD in biomedical science, immunology, pharmacology, toxicology, ecotoxicology
or environmental biology and be strongly motivated to carry out research. In order to
apply or for further information, please contact Ann-Marie Ford on
a.glenny@napier.ac.uk.

Project start date July/August 2009
Closing date for applications:
Interview date: (Edinburgh Napier University, Edinburgh)

				
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posted:11/9/2011
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