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EFFECTS OF MONOSODIUM GLUTAMATE ON LIVER ENZYMES

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					EFFECTS OF MONOSODIUM GLUTAMATE ON LIVER ENZYMES

Buraimoh AA 1, Bako IG2 and Bello B1

1. DEPARTMENT OF HUMAN ANATOMY, FACULTY OF MEDICINE, AHMADU BELLO
UNIVERSITY, ZARIA, NIGERIA.

2. DEPARTMENT OF HUMAN PHYSIOLOGY, FACULTY OF MEDICINE, AHMADU BELLO
UNIVERSITY, ZARIA, NIGERIA.



Monosodium glutamate, also known as sodium glutamate (MSG), is a sodium salt of the
naturally occurring non-essential amino acid glutamic acid. It is a white crystalline powder
used as a food additive and is commonly marketed as a flavor enhancer.Trade names of
monosodium glutamate include Ajinomoto, Vetsin, and Accent.It was once predominantly
made from wheat gluten, but is now mostly made from bacterial fermentation. Liver
enzymes are proteins that help to speed up a chemical reaction in the liver and they are
found in normal plasma or serum, and can be divided into the following: aspartate
aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase(ALP). AST
and ALT are sensitive indicators of liver damage.This study is aimed at investigating the
effect that monosodium glutamate could have on the activities of liver enzymes. A total of
20 wistar rats were used. The rats were divided into four groups; Group I was the control,
group II received 0.6mg/kg, Group III received 6mg/kg and group IV received 60mg/kg via
oral intubation for a period of 14 days. Blood samples were collected and centrifuged for 10
minutes for biochemical analysis. Our results indicated rise in the level of activities of the
enzymes when compared with the control. However, the rise was only statistically
significant at P< 0.05 for AST and ALT in Group II and also for ALT in Group IV. Based on our
observation, we therefore conclude that Monosodium glutamate alters the activities of liver
enzymes and could have detrimental effects on the liver. Therefore, caution should be taken
in its usage.

				
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posted:11/9/2011
language:English
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