cologne_conference by pengxiang

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									                                                                                          DIE AKADEMIE
                                                                                          FRESENIUS




International Fresenius Conference

Endocrine Disrupters in
91/414/EEC
21 – 22 June 2004
Cologne/Germany

Highlights:
• Update on the OECD ecotoxicology work
  for endocrine disrupters

• Toxicological and ecotoxicological
  assessment

• Test activities in the aquatic and
  terrestrial compartment

• Assessing effects of endocrine
  disrupters in fishes, amphibians, birds
  and mammals

• Present and future regulatory systems –   Some of the speakers:
  view from the European Commission
                                            John Ashby Syngenta Central Toxicology Laboratory • Vladimir
• Regulator’s and industry’s view on a      Bencko Charles University • Elaine Z. Francis U.S.
  regulatory system                         Environmental Protection Agency • Andreas Gies Federal
                                            Environmental Agency • Werner Kloas Leibniz-Institute for
                                            Freshwater Ecology and Inland Fisheries • Canice Nolan
                                  nd        European Commission • Claudia E. Olivieri BASF • Samuel W.
                        orities a
          d fee for auth d education        Page World Health Organization • Ralf Schulz Syngenta •
  Reduce s for advance
             n                              Hans-Christian Stolzenberg OECD • Pieter W. Wester
  institutio
                                            National Institute for Public Health and the Environment • Sabine
                                            Zok BASF • and others
Monday
21 June 2004

8.45 Refreshments by courtesy of Holiday       10.40 Panel discussion                                Endocrine disrupter testing and
     Inn Cologne am Stadtwald                                                                            assessment activities
                                               11.00 Coffee break
9.30 Welcoming speech by
                                                                                               15.50 Update on the OECD Ecotoxicology
Andreas Zumdick, Head of Competence            11.30 Situation in Germany                            Work for Endocrine Disrupters
Center Agro, INSTITUT FRESENIUS AG,
                                               Andreas Gies, Head of the department for        • Work on endocrine disrupters as a special
Taunusstein/Germany
                                               chemicals assessment and gene technology,         activity of the OECD test guidelines pro-
and
                                               Federal Environmental Agency, Berlin/Germany      gramme
the chairman,
                                                                                               • OECD conceptual framework for testing and
Ralf Schulz, Ecological Sciences, Syngenta
                                                                                                 assessment of endocrine disrupters
Crop Protection AG, Bracknell, Berkshire/UK    12.00 Overview of the U.S. Environmental
                                                                                               • Validation work as a distinguished part of
                                                     Protection Agency's Endocrine
                                                                                                 test method development
                                                     Disrupters Screening Program
                                                                                               • Current activities in particular areas (fish,
                                               • History and implementation of the               amphibians, invertebrates, birds)
                                                 Endocrine Disrupters Screening Program
   Identification of endocrine disrupters                                                      Hans-Christian Stolzenberg, Environmental,
                                                 • Development and validation of tier 1 and
                                                                                               Health and Safety Division, OECD, Paris/France
                                                   tier 2 assays
                                                                                               – Scientific Staff/Administrator, Federal
                                                 • Approach for priority setting
                                                                                               Environmental Agency (UBA), Berlin/Germany
9.40 IPCS/WHO perspectives on what               • Policies for regulatory implementation
                                                                                               Anne Gourmelon, Environment, Health and
     we need to know about endocrine           • Research that supports the Endocrine
                                                                                               Safety Division, OECD, Paris/France (co-au-
     disrupters                                  Disrupters Screening Program
                                                                                               thor)
Samuel W. Page, Scientist, World Health        Elaine Z. Francis, National Program Director
Organization, Geneva/Switzerland               for the Endocrine Disrupters Research
                                                                                               16.30 Human exposure to endocrine dis-
Terry Damstra, Team Leader, IPCS/IRRU,         Program, U.S. Environmental Protection
                                                                                                     rupters: risk assessment and a case
World Health Organization, Research Triangle   Agency, Washington, DC/USA
                                                                                                     study trigger for the ecotoxicology
Park, North Carolina/USA (co-author)
                                                                                               • Human exposure to endocrine disrupters
                                               12.30 Panel discussion
                                                                                                 from a central European Perspective
                                                                                               • Risk assessment of breast fed children –
                                               12.50 Lunch                                       grant of the Ministry of environment, Czech
           Regulatory perspective                                                                Republic
                                                                                               • Some preliminary experiences from the
                                               14.20 Industry expectations from a regula-
                                                                                                 PCBRISK 5th Framework Project "Evaluating
                                                     tory system: the agricultural outlook
                                                                                                 human health risk from low-dose & long-
10.10 Endocrine disruption in the eva-
                                               Claudia E. Olivieri, Global Issues Manager,       term PCB exposure”
      luation of active substances in plant
                                               BASF Agricultural Products, BASF Corporation,
      protection products under Directive                                                      Vladimir Bencko, Head of Institute of Hygiene
                                               Research Triangle Park, North Carolina/USA
      91/414/EEC                                                                               & Epidemiology, Charles University of Prague,
                                                                                               First Faculty of Medicine, Prague/Czech
Canice Nolan, Head of Sector – Plant
                                               15.00 Panel discussion                          Republic
Protection Products, DG Health and Consumer
Protection, European Commission,
Brussels/Belgium                               15.20 Coffee break                              17.00 Panel Discussion
                                               Tuesday
                                               22 June 2004

Approx.                                        8.30 Welcoming speech by the chairman            11.10 Assessing effects of endocrine
17.30 Summary of the results by the                                                                   disrupters in birds and mammals -
      chairman                                                                                        test methods and risk assessment

                                                     Endocrine disrupter testing and            • Test strategy - where are additional test
                                                         assessment activities                    methods needed?
                                                                                                • Additional endpoints - specificity and
                                                                                                  biological relevance
                                               8.40 Ecotoxicology testing in laboratory         • Avian Two Generation Test
                                                    fish with reference to endocrine            • Evaluation and risk assessment for
                                                    disrupters: partial life cycle test           endocrine modulators
                                                    with emphasis on histopathology
                                                                                                Sabine Zok, Department of Product Safety,
                                               Pieter W. Wester, Laboratory for Toxicology,     BASF AG, Ludwigshafen/Germany
                                               Pathology and Genetics, National Institute for
 After the first conference day has ended,
                                               Public Health and the Environment (RIVM),
 Akademie Fresenius would like to invite the                                                    11.40 Combination effects and risk
                                               Bilthoven/The Netherlands
 participants to a leisurely evening in the                                                           assessment
 Private Brewery Sion - a perfect opportuni-
                                                                                                Andreas Kortenkamp, University of London,
 ty for talks and discussions with speakers    9.10 Proposed enhanced and new OECD
                                                                                                The School of Pharmacy, Centre for
 and participants – and perhaps for a sight-        guidelines to determine endocrine
                                                                                                Toxicology, London/UK
 seeing tour through the Old Town of                disrupting effects in fish
 Cologne.
                                               • Fish screens and tests
                                                                                                12.10 Mammalian endocrine disruption –
                                               • Additional, endocrine specific endpoints
                                                                                                      where are we a decade on?
                                               • Status of the pre-validation work
                                                                                                • Assays for endocrine disruption
                                               Thomas Knacker, Managing Director, ECT
                                                                                                • Complicating factors
                                               Ökotoxikologie GmbH, Flörsheim/Germany
                                                                                                • The bigger picture

                                                                                                John Ashby, Principal Syngenta Fellow,
                                               9.40 Test activities in the aquatic
                                                                                                Syngenta Central Toxicology Laboratory,
                                                    compartment – assessment of
                                                                                                Macclesfield, Cheshire/UK
                                                    effects of endocrine disrupters in
                                                    amphibians
                                                                                                12.40 Panel Discussion and summary of
                                               • Amphibians as model to study endocrine
                                                                                                      results by the chairman
                                                 disrupters
                                               • Potential effects of endocrine disrupters on
                                                 reproductive biology and thyroid system of     13.30 Lunch and end of the conference
                                                 amphibians (methodology)
                                               • Testing strategies for endocrine disrupters
                                                 using amphibians as model

                                               Werner Kloas, Head of Department of Inland
                                               Fisheries, Leibniz-Institute for Freshwater
                                               Ecology and Inland Fisheries, Berlin/Germany


                                               10.10 Panel Discussion

                                               10.40 Coffee break
Profile of
Lecturers

               John Ashby is Syngenta Senior                     Thomas Knacker has been                             Ralf Schulz is Syngenta Fellow
               Fellow and has been with Syn-                     Managing Director of the ECT                        for Ecological Sciences based in
               genta Central Toxicology Labo-                    Ökotoxikologie GmbH, Flörsheim/                     Bracknell, Berkshire/UK. He held
               ratory, Cheshire/UK, for the past                 Germany, since 1993. 1984, he                       a postdoctoral fellowship with the
               30 years. For the past nine years                 started as Manager of the                           Department of Zoology at the
he has concentrated on the study of endocrine       Department of Ecotoxicology and Biode-             University of Stellenbosch/South Africa during
disruption in mammals. John Ashby has publis-       gradation at Battelle Institute, Frankfurt/        2001 and 2002.
hed over 500 papers/articles/book chapters and      Germany. Furthermore, Thomas Knacker has
is Editorial Board of six international journals.   co-ordinated several research projects.
                                                                                                                        Hans-Christian Stolzenberg is
                                                                                                                        seconded from February to June
              Vladimir Bencko is Head of the                      Andreas Kortenkamp became a                           2004 to the OECD secretariat and
              Institute of Hygiene and Epide-                     senior lecturer in Toxicology at                      in charge for the ecotoxicology
              miology at the First Faculty of                     the School of Pharmacy,                               work on endocrine disrupters. He
              Medicine at the Charles Uni-                        London/UK. Combination effects       is affiliated to the Federal Environmental Agency
              versity of Prague/Czech Republic.                   of mixtures of environmental pol-    in Berlin/Germany since 1997. Since April 2000
His main fields of interest are health aspects of   lutants with endocrine-disrupting properties is    his work has been focussed on technical and
human exposure to persistent xenobiotics in en-     one area of his current research interests.        scientific support of national co-ordination of
vironmental and occupational settings.              Andreas Kortenkamp ist member of the British       the OECD and on programmes for EU test
                                                    Toxicology Society.                                guidelines. Hans-Christian Stolzenberg is
                                                                                                       member of the OECD Validation Management
              Elaine Z. Francis is National                                                            Group for Ecotoxicology Testing.
              Program Director for the U.S.         Canice Nolan is Head of the Sector on Plant
              Environmental Protection Agen-        Protection Products at DG Health and Consumer
              cy's endocrine disrupters re-         Protection, European Commission, Brussels/         Pieter W. Wester is working for the Laboratory
              search program, coordinating the      Belgium. He has been working in this area sin-     for Toxicology, Pathology and Genetics at the
multi-million dollar intramural and extramural      ce 1998. Previously he worked for DG Research      National Institute for Public Health and the
research programs. She has been a develop-          with responsibility for environment, health and    Environment (RIVM), Bilthoven/The Nether-
mental/reproductive toxicologist at EPA for         chemical safety.                                   lands. He has been Head of the department for
almost 24 years.                                                                                       pathology of the Laboratory for Pathology and
                                                                                                       Immunobiology since 1990.
                                                                  Claudia E. Olivieri works at BASF
               Andreas Gies became Head of                        Corporation, Research Triangle
               the department for chemicals                       Park, North Carolina/USA, as                      Sabine Zok is working as
               assessment and gene technology                     Global Issues Manager for BASF                    ecotoxicologist in the Department
               at the Federal Environmental                       Agricultural Products. She has                    Product Safety of BASF AG, Lud-
               Agency, Berlin/Germany, in 2002.     worked in industry for more than 7 years in eco-                wigshafen/Germany. Her special
He is with the Federal Environmental Agency as      toxicology, regulatory affairs and issues                       fields of interest are the aquatic-
senior scientist in the chemicals notification      management. In addition Claudia E. Olivieri has    and avian toxicology and the development of
unit since 1988 and later as the Head of the        developed and taught workshops on ecotoxico-       test methods for endocrine effects.
section for environmental assessment. Andreas       logy risk assessment for crop protection.
Gies has co-ordinated the work of the agency
on endocrine disruption since 1996.                                                                                   Andreas Zumdick is Head of the
                                                    Samuel W. Page is currently a staff scientist in                  Competence Center Agro and the
                                                    the International Programme on Chemical                           GLP test facility at INSTITUT
               Werner Kloas became Head of          Safety at World Health Organization in Geneva/                    FRESENIUS AG in Taunusstein/
               department of inland fisheries at    Switzerland. He is Co-ordinator for the Project                   Germany. He has worked for 12
               the Leibniz-Institute for Fresh-     to Update the Principles and Methods for the       years in the crop production industry managing
               water Ecology and Inland             Risk Assessment of Chemicals in Food. Samuel       regulatory studies on crop and soil residues,
               Fisheries, Berlin, in 1999. Since    Page has authored or co-authored more than         plant/soil metabolism and E-Fate studies.
2002 he has been full professor for endocrino-      one hundred research publications.
logy at the Institute of Biology, Humboldt
University, Berlin/Germany.
Whom do you                              The Organizers                                    Sponsoring
meet?                                                                                      and Exhibition

Sectors that should take part:           INSTITUT FRESENIUS soon became and has            Take advantage of our conference – use it as
• Agrochemical industry                  remained one of the leading German labora-        a platform to present your products and ser-
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• Producers of biocides
                                         offering services in the field of chemical,       ticipants.
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• Authorities (agricultural inspection   has established a network of well-equipped        To get more information, simply use the fax
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• Contract laboratories                  in both the European and international            ful presentations, please contact us:
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• Environmental Consultants
                                                                                           Frank Ropers
                                         Covering a wide range of analytical and           phone +49 (0) 231 75896 85
                                         consulting services, Fresenius offers com-        email: fropers@akademie-fresenius.de
Groups that should take part:            prehensive specialised high-technology
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  directors, members of supervisory      the field of the registration of agrochemicals.
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Date and location                                                           Fax-Registration
21 - 22 June 2004                                                           +49 (0) 231 75896 53
Conference hotel: You will stay at the conference hotel Holiday Inn         ■ Yes, I am pleased to accept the invitation to attend the
Cologne am Stadtwald (formerly Cologne Queens Hotel), which is sur-                 International Fresenius Conference on Endocrine
rounded by parkland. It is well located for access within minutes to                Disrupters in 91/414/EEC (Event No. VK1771), 21 - 22 June
the motorway junction Köln-West and Cologne city. The airport is just               2004, Fee: € 1,395.00 plus 16 % VAT.
18 kilometers away. In the conference hotel, a limited number of rooms
is available for our participants at reduced rates. Please make your                ■    I am a representative of a university, an employee of an
reservation directly with the hotel up to 4 weeks before the beginning                   authority or an institution for advanced education and
of the conference using "Fresenius” as reference.                                        therefore eligible for a reduced fee of € 795.00 for the
                                                                                         conference plus 16 % VAT.

                                                                                    ■     I would like to accept the invitation to attend the event
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                                                                                    and exhibition possibilities.
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(Project Manager)
and
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(Project Organisation)                                                      bottom right of the letter):
Tel. +49 (0) 231 75896 48,
email mstratmann@akademie-fresenius.de
                                                                            name, first name


Fee: The fee for both days of the conference is € 1,395.00 plus 16 %
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