Fernando J. Martinez, M.D., M.S.
Faculty Appointment: Professor of Internal Medicine
Director, Pulmonary Diagnostic Services
Co-Medical Director, Lung Transplantation
Specialty: Pulmonary & Critical Care Medicine
Clinical Interests: Interstitial lung disease, COPD, lung transplantation,
exercise physiology, respiratory muscle function, pulmonary
rehabilitation, dyspnea, cost-effective use of diagnostic
resources, lung volume reduction.
Research Interests: Interstitial lung disease, COPD, respiratory muscle function,
physiologic response to lung transplantation, optimal
diagnostic approach to the evaluation of dyspnea.
Degree: M.D., 1983, University of Florida School of Medicine
M.S., 2001, University of Michigan School of Public Health
Biostatistics and Clinical Study Design
Residency: Beth Israel Hospital 1984-1986
Fellowships: Boston University Pulmonary Center 1986-1989
Certifications: 1986, Internal Medicine, ABIM Valid Indefinitely
1988, Pulmonary Medicine, ABIM Valid Indefinitely
1989, Critical Care Medicine; Recertified 2000-2010 and
2010-2020, ABIM
Faculty Appointment Date: 9/01/1991
Clinical Address: A. Alfred Taubman Health Care Center
3rd Floor Taubman Center, Reception Area’s A & C
3916 Taubman Center
1500 E. Medical Center Drive
Ann Arbor, MI 48109-5360
Appointments: Toll Free: 1-888-284-5864 (LUNG) or (734) 763-7668
Nursing: Toll Free: 1-888-284-5864 (LUNG) or (734) 763-7668
Option selections: Appointments – 1
Medical Records – 2; Billing – 3; Test Results – 4
Prescription Refills – 5
Leave a message or to speak to a nurse - 6
M-Line physician consultation: 1-800-962-3555
Clinic Fax: (734) 936-3494
Academic Office Address: Pulmonary and Critical Care Medicine
University of Michigan Health System
3916 Taubman Center
1500 E. Medical Center Drive
Ann Arbor, MI 48109-5360
Academic Office Telephone: (734) 763-2540
Academic Office Fax: (734) 936-5048
Recent Articles:
1. Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV, Cordier JF,
Flaherty KR, Lasky JA, Lynch DA, Ryu JH, Swigris JJ, Wells AU, Ancochea J, Bouros D,
Carvalho C, Costabel U, Ebina M, Hansell DM, Johkoh T, Kim DS, King TE Jr, Kondoh
Y, Myers J, Müller NL, Nicholson AG, Richeldi L, Selman M, Dudden RF, Griss BS,
Protzko SL, Schünemann HJ; on behalf of the ATS/ERS/JRS/ALAT Committee on
Idiopathic Pulmonary Fibrosis. An Official ATS/ERS/JRS/ALAT Statement: Idiopathic
Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management. Am J
Respir Crit Care Med. 2011;183(6):788-824.
http://www.ncbi.nlm.nih.gov/pubmed/21471066
2. Erb-Downward JR, Thompson DL, Han MK, Freeman CM, McCloskey L, Schmidt LA,
Young VB, Toews GB, Curtis JL, Sundaram B, Martinez FJ, Huffnagle GB. Analysis of
the Lung Microbiome in the “Healthy” Smoker and in COPD. PLoS One.
2011;6(2):e16384. http://www.ncbi.nlm.nih.gov/pubmed/21364979
3. Woodruff PG, Albert RK, Bailey WC, Casaburi R, Connett JE, Cooper JA Jr, Criner GJ,
Curtis JL, Dransfield MT, Han MK, Harnden SM, Kim V, Marchetti N, Martinez FJ,
McEvoy CE, Niewoehner DE, Reilly JJ, Rice K, Scanlon PD, Scharf SM, Sciurba FC,
Washko GR, Lazarus SC; Copd Clinical Research Network. Randomized Trial of
Zileuton for Treatment of COPD Exacerbations requiring Hospitalization. COPD.
2011;8(1):21-9. http://www.ncbi.nlm.nih.gov/pubmed/21299475
4. Rennard SI, Calverley PM, Goehring UM, Bredenbröker D, Martinez FJ. Reduction of
Exacerbations by the PDE4 Inhibitor Roflumilast – The Importance of Defining Different
Subsets of Patients with COPD. Respir Res. 2011;12:18.
http://www.ncbi.nlm.nih.gov/pubmed/21272339
5. Badri L, Murray S, Liu LX, Walker NM, Flint A, Wadhwa A, Chan KM, Toews GB, Pinsky
DJ, Martinez FJ, Lama VN. Mesenchymal Stromal Cells in Bronchoalveolar Lavage as
Predictors of Bronchiolitis Obliterans Syndrome. Am J Respir Crit Care Med.
2011;183(8):1062-70. http://www.ncbi.nlm.nih.gov/pubmed/21169468
6. Trujillo G, Meneghin A, Flaherty KR, Sholl LM, Myers JL, Kazerooni EA, Gross BH, Oak
SR, Coelho AL, Evanoff H, Day E, Toews GB, Joshi AD, Schaller MA, Waters B, Jarai
G, Westwick J, Kunkel SL, Martinez FJ, Hogaboam CM. TLR9 Differentiates Rapidly
from Slowly Progressing Forms of Idiopathic Pulmonary Fibrosis. Sci Transl Med.
2010;2(57):57ra82. http://www.ncbi.nlm.nih.gov/pubmed/21068441
7. Ganesan S, Faris AN, Comstock AT, Chattoraj SS, Chattoraj A, Burgess JR, Curtis JL,
Martinez FJ, Zick S, Hershenson MB, Sajjan US. Quercetin Prevents Progression of
Disease in Elastase/LPS-exposed mice by negatively regulating MMP Expression.
Respir Res. 2010 Sep 28;11:131. http://www.ncbi.nlm.nih.gov/pubmed/20920189
8. Han MK, Agusti A, Calverley PM, Celli BR, Criner G, Curtis JL, Fabbri LM, Goldin JG,
Jones PW, Macnee W, Make BJ, Rabe KF, Rennard SI, Sciurba FC, Silverman EK,
Vestbo J, Washko GR, Wouters EF, Martinez FJ. Chronic Obstructive Pulmonary
Disease Phenotypes: The Future of COPD. Am J Respir Crit Care Med.
2010;182(5):598-604. http://www.ncbi.nlm.nih.gov/pubmed/20522794
9. Freeman CM, Han MK, Martinez FJ, Murray S, Liu LX, Chensue SW, Polak TJ,
Sonstein J, Todt JC, Ames TM, Arenberg DA, Meldrum CA, Getty C, McCloskey L,
Curtis JL. Cytotoxic Potential of Lung CD8(+) T Cells Increases with Chronic Obstructive
Pulmonary Disease Severity and with in Vitro Stimulation by IL-18 or IL-15. J Immunol.
2010;184(11):6504-13. http://www.ncbi.nlm.nih.gov/pubmed/20427767
10. Schneider D, Ganesan S, Comstock AT, Meldrum CA, Mahidhara R, Goldsmith AM,
Curtis JL, Martinez FJ, Hershenson MB, Sajjan U. Increased Cytokine Repsonse of
Rhinovirus-infected Airway Epithelial Cells in Chronic Obstructive Pulmonary Disease.
Am J Respir Crit Care Med. 2010;182(3):332-40.
http://www.ncbi.nlm.nih.gov/pubmed/20395558
11. Yawn BP, Mapel DW, Mannino DM, Martinez FJ, Donohue JF, Hanania NA, Kosinski M,
Rendas-Baum R, Mintz M, Samuels S, Dalal AA; Lung Function Questionnaire Working
Group. Development of the Lung Function Questionnaire (LFQ) to identify Airflow
Obstruction. Int J Chron Obstruct Pulmon Dis. 2010;5:1-10.
http://www.ncbi.nlm.nih.gov/pubmed/20368906
12. Benzo RP, Chang CC, Farrell MH, Kaplan R, Ries A, Martinez FJ, Wise R, Make B,
Sciurba F; NETT Research Group. Physical Activity, Health Status and risk of
hospitalization in Patients with Severe Chronic Obstructive Pulmonary Disease.
Respiration. 2010;80(1):10-8. http://www.ncbi.nlm.nih.gov/pubmed/20234126
13. Cho MH, Washko GR, Hoffmann TJ, Criner GJ, Hoffman EA, Martinez FJ, Laird N,
Reilly JJ, Silverman EK. Cluster Analysis in Severe Emphysema Subjects using
Phenotype and Genotype Data: An Exploratory Investigation. Respir Res. 2010;11:30.
http://www.ncbi.nlm.nih.gov/pubmed/20233420
14. Hanania NA, Mannino DM, Yawn BP, Mapel DW, Martinez FJ, Donohue JF, Kosinski M,
Rendas-Baum R, Mintz M, Samuels S, Jhingran P, Dalal AA. Predicting Risk of Airflow
Obstruction in Primary Care: Validation of the Lung Function Questionnaire (LFQ).
Respir Med. 2010;104(8):1160-70. http://www.ncbi.nlm.nih.gov/pubmed/20226647
15. Giardino ND, Curtis JL, Andrei AC, Fan VS, Benditt JO, Lyubkin M, Naunheim K, Criner
G, Make B, Wise RA, Murray SK, Fishman AP, Sciurba FC, Liberzon I, Martinez FJ.
Anxiety is Associated with Diminished Exercise Performance and Quality of Life in
Severe Emphysema: A Cross-sectional Study. Respir Res. 2010 Mar 9;11:29.
http://www.ncbi.nlm.nih.gov/pubmed/20214820
16. Giardino ND, Curtis JL, Abelson JL, King AP, Pamp B, Liberzon I, Martinez FJ. The
Impact of Panic Disorder on Interoception and Dyspnea Reports in Chronic Obstructive
Pulmonary Disease. Biol Psychol. 2010;84(1):142-6.
http://www.ncbi.nlm.nih.gov/pubmed/20176074
17. Fell CD, Martinez FJ, Liu LX, Murray S, Han MK, Kazerooni EA, Gross BH, Myers J,
Travis WD, Colby TV, Toews GB, Flaherty KR. Clinical Predictors of a Diagnosis of
Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2010;181(8):832-7.
http://www.ncbi.nlm.nih.gov/pubmed/20056903
18. Han MK, Swigris J, Liu L, Bartholmai B, Murray S, Giardino N, Thompson B, Frederick
M, Li D, Schwarz M, Limper A, Flaherty K, Martinez FJ. Gender influences Health-
Related Quality of Life in IPF. Respir Med. 2010;104(5):724-30.
http://www.ncbi.nlm.nih.gov/pubmed/20036113
19. Washko GR, Martinez FJ, Hoffman EA, Loring SH, Estépar RS, Diaz AA, Sciurba FC,
Silverman EK, Han MK, Decamp M, Reilly JJ; National Emphysema Treatment Trial
Research Group. Physiological and computed tomographic predictors of outcome from
lung volume reduction surgery. Am J Respir Crit Care Med. 2010;181(5):494-500.
http://www.ncbi.nlm.nih.gov/pubmed/19965810
20. Fell CD, Liu LX, Motika C, Kazerooni EA, Gross BH, Travis WD, Colby TV, Murray S,
Toews GB, Martinez FJ, Flaherty KR. The prognostic value of cardiopulmonary exercise
testing in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2009;179(5):402-7.
http://www.ncbi.nlm.nih.gov/pubmed/19074597
21. Chan KM, Martinez FJ, Chang AC. Nonmedical therapy for chronic obstructive
pulmonary disease. Proc Am Thorac Soc. 2009;6(1):137-45.
http://www.ncbi.nlm.nih.gov/pubmed/19131539
22. Joshi AD, Fong DJ, Oak SR, Trujillo G, Flaherty KR, Martinez FJ, Hogaboam CM.
Interleukin-17-mediated immunopathogenesis in experimental hypersensitivity
pneumonitis. Am J Respir Crit Care Med. 2009;179(8):705-16.
http://www.ncbi.nlm.nih.gov/pubmed/19151189
23. Hyett B, Martinez FJ, Gill BM, Mehra S, Lembo A, Kelly CP, Leffler DA. Delayed
radionucleotide gastric emptying studies predict morbidity in diabetics with symptoms of
gastroparesis. Gastroenterology. 2009;137(2):445-52.
http://www.ncbi.nlm.nih.gov/pubmed/19410575
24. Kim WJ, Silverman EK, Hoffman E, Criner GJ, Mosenifar Z, Sciurba FC, Make BJ, Carey
V, Estépar RS, Diaz A, Reilly JJ, Martinez FJ, Washko GR; NETT Research Group. CT
metrics of airway disease and emphysema in severe COPD. Chest. 2009;136(2):396-
404. http://www.ncbi.nlm.nih.gov/pubmed/19411295
25. Clark NM, Dodge JA, Partridge MR, Martinez FJ. Focusing on outcomes: making the
most of COPD interventions. Int J Chron Obstruct Pulmon Dis. 2009;4:61-77.
http://www.ncbi.nlm.nih.gov/pubmed/19436690
26. Benzo R, Farrell MH, Chang CC, Martinez FJ, Kaplan R, Reilly J, Criner G, Wise R,
Make B, Luketich J, Fishman AP, Sciurba FC; NETT Research Group. Integrating health
status and survival data: the palliative effect of lung volume reduction surgery. Am J
Respir Crit Care Med. 2009;180(3):239-46.
http://www.ncbi.nlm.nih.gov/pubmed/19483114
27. Bailey WC, Sciurba FC, Hanania NA, Donohue JF, Ferguson GT, Zibrak JD,
Sharafkhaneh A, Marcus P, Rosa K, Piault EC, Martinez FJ. Development of validation
of the Chronic Obstructive Pulmonary Disease Assessment Questionnaire (COPD-AQ).
Prim Care Respir J. 2009;18(3):198-207. http://www.ncbi.nlm.nih.gov/pubmed/19492178
28. Dransfield MT, Nahm MH, Han MK, Harnden S, Criner GJ, Martinez FJ, Scanlon PD,
Woodruff PG, Washko GR, Connett JE, Anthonisen NR, Bailey WC; COPD Clinical
Research Network. Superior immune response to protein-conjugate versus free
pneumococcal polysaccharide vaccine in chronic obstructive pulmonary disease. Am J
Respir Crit Care Med. 2009;180(6):499-505.
http://www.ncbi.nlm.nih.gov/pubmed/19556517
29. Hoeper MM, Barberà JA, Channick RN, Hassoun PM, Lang IM, Manes A, Martinez FJ,
Naeije R, Olschewski H, Pepke-Zaba J, Redfield MM, Robbins IM, Souza R, Torbicki A,
McGoon M. Diagnosis assessment, and treatment of non-pulmonary arterial
hypertension pulmonary hypertension. J Am Coll Cardiol. 2009;54(1 Suppl):S85-96.
http://www.ncbi.nlm.nih.gov/pubmed/19555862
30. Hecker L, Vittal R, Jones T, Jagirdar R, Luckhardt TR, Horowitz JC, Pennathur S,
Martinez FJ, Thannickal VJ. NADPH oxidase-4 mediates myofibroblast activation and
fibrogenic response to lung injury. Nat Med. 2009 Sep;15(9):1077-81.
http://www.ncbi.nlm.nih.gov/pubmed/19701206
31. Fabbri LM, Calverley PM, Izquierdo-Alonso JL, Bundschuh DS, Brose M, Martinez FJ,
Rabe KF; M2-127 and M2-128 study groups. Lancet. 2009;374(9691):695-703.
http://www.ncbi.nlm.nih.gov/pubmed/19716961
32. Calverley PM, Rabe KF, Goehring UM, Kristiansen S, Fabbri LM, Martinez FJ; M2-124
and M2-125 study groups. Roflumilast in symptochronic obstructive pulmonary disease:
two randomised clinical trials. Lancet. 2010;376(9747):1146.
http://www.ncbi.nlm.nih.gov/pubmed/19716960
33. Freeman CM, Martinez FJ, Han MK, Ames TM, Chensue SW, Todt JC, Arenberg DA,
Meldrum CA, Getty C, McCloskey L, Curtis JL. Lung dendritic cell expression of
maturation molecules increase with worsening chronic obstructive pulmonary disease.
Am J Respir Crit Care Med. 2009;180(12):1179-88.
http://www.ncbi.nlm.nih.gov/pubmed/19729666
34. Horowitz JC, Martinez FJ, Thannickal VJ. Mesenchymal cell fate and phenotypes in the
pathogenesis of emphysema. COPD. 2009;6(3):201-10.
http://www.ncbi.nlm.nih.gov/pubmed/19811376
35. Matsuoka S, Washko GR, Yamashiro T, Estepar RS, Diaz A, Silverman EK, Hoffman E,
Fessler HE, Criner GJ, Marchetti N, Scharf SM, Martinez FJ, Reilly JJ, Hatabu H;
National Emphysema Treatment Trial Research Group. Pulmonary hypertension and
computed tomography measurement of small pulmonary vessels in severe emphysema.
Am J Respir Crit Care Med. 2010;181(3):218-25.
http://www.ncbi.nlm.nih.gov/pubmed/19875683
36. Han MK, Bartholmai B, Liu LX, Murray S, Curtis JL, Sciurba FC, Kazerooni EA,
Thompson B, Frederick M, Li D, Schwarz M, Limper A, Freeman C, Landreneau RJ,
Wise R, Martinez FJ. Clinical significance of radiologic characterizations in COPD.
COPD. 2009;6(6):459-67. http://www.ncbi.nlm.nih.gov/pubmed/19938970
37. Muro AF, Moretti FA, Moore BB, Yan M, Atrasz RG, Wilke CA, Flaherty KR, Martinez
FJ, Tsui JL, Sheppard D, Baralle FE, Toews GB, White ES. An essential role for
fibronectin extra type III domain A in pulmonary fibrosis. Am J Respir Crit Care Med.
2008;177(6):638-45. http://www.ncbi.nlm.nih.gov/pubmed/18096707
38. Travis WD, Hunninghake G, King TE Jr, Lynch DA, Colby TV, Galvin JR, Brown KK,
Chung MP, Cordier JF, du Bois RM, Flaherty KR, Franks TJ, Hansell DM, Hartman TE,
Kazerooni EA, Kim DS, Kitaichi M, Koyama T, Martinez FJ, Nagai S, Midthun DE,
Müller NL, Nicholson AG, Raghu G, Selman M, Wells A. Idiopathic nonspecific interstitial
pneumonia: report of an American Thoracic Society project. Am J Respir Crit Care
Med.2008;178(2): 211. http://www.ncbi.nlm.nih.gov/pubmed/18388353
39. Martinez FJ, Raczek AE, Seifer FD, Conoscenti CS, Curtice TG, D'Eletto T, Cote C,
Hawkins C, Phillips AL; COPD-PS Clinician Working Group. Development and initial
validation of self-scored COPD Population Screener Questionnaire (COPD-PS). COPD.
2008;5(2):85-95. http://www.ncbi.nlm.nih.gov/pubmed/18415807
40. Minai OA, Benditt J, Martinez FJ. Natural history of emphysema. Proc Am Thorac Soc.
2008;5(4):468-74. http://www.ncbi.nlm.nih.gov/pubmed/18453357
41. Martinez FJ, Han MK, Andrei AC, Wise R, Murray S, Curtis JL, Sternberg A, Criner G,
Gay SE, Reilly J, Make B, Ries AL, Sciurba F, Weinmann G, Mosenifar Z, DeCamp M,
Fishman AP, Celli BR; National Emphysema Treatment Trial Research Group.
Longitudinal change in the BODE index predicts mortality in severe emphysema. Am J
Respir Crit Care Med. 2008;178(5):491-9.
http://www.ncbi.nlm.nih.gov/pubmed/18535255
42. Attili AK, Kazerooni EA, Gross BH, Flaherty KR, Myers JL, Martinez FJ. Smoking-
related interstitial lung disease: radiologic-clinical-pathologic correlation. Radiographics.
2008;28(5):1383-96; discussion 1396-8. http://www.ncbi.nlm.nih.gov/pubmed/18794314
43. Sundaram B, Gross BH, Martinez FJ, Oh E, Müller NL, Schipper M, Kazerooni EA.
Accuracy of high-resolution CT in the diagnosis of diffuse lung disease: effect of
predominance and distribution of findings. AJR Am J Roentgenol. 2008;191(4):1032-9.
http://www.ncbi.nlm.nih.gov/pubmed/18806139
44. Martinez FJ, Curtis JL, Albert R. Role of macrolide therapy in chronic obstructive
pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2008;3(3):331-50.
http://www.ncbi.nlm.nih.gov/pubmed/18990961
45. Make BJ, Martinez FJ. Assessment of patients with chronic obstructive pulmonary
disease. Proc Am Thorac Soc. 2008;5(9):884-90.
http://www.ncbi.nlm.nih.gov/pubmed/19056711