School of Biomedical Sciences
PhD Research Studentship
Title: The role of the tumour suppressor protein LIMD1 in lung cancer development
through regulation of the HIF1 hypoxic response.
The successful applicant will be part of a young and enthusiastic research group
examining the various function of this unique tumour suppressor gene. Specifically,
the research project will examine the novel and exciting function of LIMD1 in
preventing lung cancer development through critical regulation of the HIF1 hypoxic
response pathway. We have previously shown that the LIMD1 gene is lost in lung
cancer (Sharp TV et al PNAS 2008). Therefore, the research project will aim to link
LIMD1-HIF1 regulation and the new molecular biology the student will discover
throughout the course of their PhD, to lung cancer development and also the
physiological response to hypoxia.
This project will involve the use of physiological, biochemical and molecular
techniques together with primary lung cell culture, siRNA methodology and Deep
Sequencing thereby providing comprehensive skills and training to students
embarking on a career in biomedical research. This project will be jointly supervised
by Dr Tyson V. Sharp and Dr Tim Constantin (for more details see:
http://www.nottingham.ac.uk/biomedsci/).
Applicants should have, or will expect to attain at least a 2i degree classification in
biochemistry, pharmacology, neuroscience or physiology (or a related discipline).
This studentship is available for a period of three years and provides a stipend of at
least £13,590 per annum. Please note that certain eligibility conditions apply, and
therefore, this studentship is only available to UK/EU citizens ordinarily resident in the
UK. Successful applicants are identified in a 2-stage process involving appraisal by
both the academic supervisors, and by the School’s Postgraduate Selection Panel.
Informal enquiries may be addressed to Dr Tyson V. Sharp Email:
Tyson.Sharp@Nottingham.ac.uk
Applications, with a detailed CV and the names and addresses of 2 referees, should be
sent to Dr Tyson Sharp, School of Biomedical Sciences, Queen’s Medical Centre,
Nottingham NG7 2UH. Please quote ref. DTA2011TS. Open until filled.
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