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NHMRC FUNDED RESEARCH INTO BURNS, WOUNDS AND RELATED ISSUES 2000-2008

2000 2001 2002 2003 2004 2005 2006 2007 2008

All Burns, Wounds and

Related Issues by CY $325,497 $862,431 $1,011,966 $1,433,525 $1,293,162 $1,525,198 $1,278,134 $1,419,382 $1,651,365

Report Run: 4 June 2008

Source: Extracted from NHMRC research databases RMIS/GMS as at Jun 08



2000-01 2001-02 2002-03 2003-04 2004-05 2005-06 2006-07 2007-08 2008-09

All Burns, Wounds and

Related Issues FY

$352,325 $1,144,184 $1,151,575 $1,463,679 $1,345,260 $1,465,588 $1,348,884 $1,535,376 $1,595,886



Methodology: NHMRC Research funding datasets rely entirely on the information provided by the Chief Investigators through the application process. Decisions

on allocation to particular disease and health issue datasets are made subjectively by the NHMRC Evaluation and Reporting Section (supported by other internal

review mechanisms) based on the information provided. The key search parameters listed above form the basis of the coverage of this dataset. Lay descriptions,

where available have also been reviewed to support the allocation.

Keywords: vaccine, vaccination, vaccinate, immunize, immunisation, innoculate, innoculation,antiviral, anti-viral, viral immunity

Grant Types:Includes all grant types except IRIISS and equipment grants

Fields of Research: Review all but in particular Immunology FOR

GMS Admin Type: NH PH

GMS Budget Type: 4

GMS App ID range: 900000 - 009999

Status: Accepted, Approved, Payments can be made, Suspended, Terminated, Completed

Where: Start Year >= 2000

Pay Type: Calendar year budgets. Excludes claims. Excludes GST

Note: All figures shown are the cash amounts awarded to recipients in the calendar year

Data source: These data are sourced from the pre 2000 NHMRC Grants Management Systems (GMS) and post 1999 NHMRC Research Management

Information Systems (RMIS) grants databases.

NHMRC FUNDED RESEARCH INTO BURNS, WOUNDS AND RELATED ISSUES 2000-2008

Keywords: burns, scald, heat, caustic, friction, third degree, skin grafting, wound healing, pressure therapy, epidermal cells , dressing,

adhesive elastic bandage, cosmetic, partial thickness, scarring, cultured epithelial autograft , cultured cells, dermabrasion

Report Run: 4 June 2008

Source: Extracted from NHMRC research databases RMIS/GMS as at Jun 08

Summary Notes

1. This dataset contains the details of all NHMRC funded research grants that have been identified as having a connection with the

research area of Burns, wounds and related Issues through search of the Chief Investigator provided keyword and titles contained in

the NHMRC research database. Relevance to the research area in question may be either immediate or be a longer term perceived

benefit. This dataset was current as at 4 June 2008 but is subject to change over time.

Summary of Expenditure: Burns, Wounds and Related Issues

2000 $325,497 Actual Expenditure 2 grants NHMRC Research Funding 2000-2008

2001 $862,431 Actual Expenditure 8 grants Burns and Wounds

2002 $1,011,966 Actual Expenditure 10 grants $2,000

Thousands

2003 $1,433,525 Actual Expenditure 15 grants $1,600

2004 $1,293,162 Actual Expenditure 12 grants

2005 $1,525,198 Actual Expenditure 14 grants $1,200

2006 $1,278,134 Actual Expenditure 10 grants

$800

2007 $1,419,382 Actual Expenditure 12 grants

2008 $1,651,365 Forecast Expenditure 15 grants $400

Total $10,800,660 As at Dec 2008

2009 $1,542,656 Forward commitments 13 grants $0

2010 $919,433 Forward commitments 8 grants 2000 2001 2002 2003 2004 2005 2006 2007 2008

2011 $434,380 Forward commitments 3 grants

Total $13,697,129 Incl out years

2 . Forward commitments funding data for out-years (ie beyond 2008) is subject to change when new grants are awarded in subsequent years





Grant Id CIA Grant Type Grant Subtype Scientific Title Simplified Title Admin Institutution

114408 Prof David A Power NHMRC Project Grants How from experimental acute renal Health

St. Vincent's

Standard Project Grant HB-EGF promotes recoverydoes the kidney repair itself? failure

124331 A/Pr Peter AW Rogers NHMRC Project Grants New Monash University

Research Fellowship Endometrial angiogenesis blood vessel growth in the human uterus

139021 Dr Robin M SCAIFE NHMRC Project Grants Signalling by Cbl: investigation

University of Western Australia

Standard Project Grant Regulation of signal transduction to the cytoskeleton of effects on the cytoskeleton, cell ad

142942 Dr Alpha S.K. Yap NHMRC Project Grants Receptor tyrosine complex between receptor protein tyrosine phosp

University of Queensland

Standard Project Grant Functional characterization of a signalingphosphatase-E-cadherin signal complex

143054 Prof John S. Mattick NHMRC Project Grants Pseduomonas aeruginosa of type IV Queensland

University of

Standard Project Grant Genetic dissection of the biogenesis and function infections fimbriae of Pseudomonas aerug

143061 of blood vessel vessel development Queensland

University of

Prof Peter A Koopman NHMRC Project Grants Standard Project Grant Transcriptional control Control of blooddevelopment by Sox18

145654 Dr Pritinder Kaur Skin stem cell biology stem cells

NHMRC Project Grants Standard Project Grant Developmental potential of murine keratinocyte University of Melbourne

145828 Characterisation transgenic mice: of Melbourne

University PAR2 knock-out mice

A/Pr Thomas M Cocks NHMRC Project Grants Research Fellowship Characterisation of PAR2 knockout and of inflammation intowards gene therapy for epithelia

183770 CJ Martin Fellowship Differential gene expression in hepatic wound healing.hepatic wound healing. Medicine and

Dr Nicholas A Shackel Training Fellowship (Overseas) Centenary Institute of Cancer

Differential gene expression in

195100 nerve stimulation to improve healing of chronic venous

National Ageing Research Institute

A/Pr Peteris J Darzins NHMRC Project Grants Standard Project Grant Non-invasive electricalUsing nerve stimulation to help chronic leg wounds healleg ulcers

243706 Dr John F Fraser SCHOLARSHIP Fetal wound Fetal wound healing; an ovine model for scarless wound recovery in

Royal Children's Hospital, Brisbane

Medical Postgraduate Scholarship healing; an ovine model for scarless wound recovery in burns patients

249414 Treatment of kidney disease using specific against Westmead of e

The Children's Hospital at TCR subsets

Prof David CH Harris NHMRC Project Grants Standard Project Grant Treatment of chronic proteinuric renal disease with DNA vaccines vaccines against inflamm

251535 Dr Pritinder Kaur Factors of the tissue regeneration of Melbourne

University

NHMRC Project Grants Standard Project Grant Microenvironmental regulation affecting skinregenerative capacity of keratinocyte stem cells

253805 mechanisms of the profibrogenic effect of leptin in the liver.

Dr Isabelle Leclercq NHMRC Project Grants Standard Project Grant Cellular and molecular Leptin and hepatic fibrosis University of Sydney

253855 NHMRC Project Grants Development Grant

Dr Christopher J Jackson a promoter of wound promoteUniversity of healing

Activated protein C as Activated protein C tohealing woundSydney

258419 Dr Colin CW Chong SCHOLARSHIP Transforming Transforming growth factor-beta (TGF-B) and the role resolution of o

University of Sydney

Medical Postgraduate Scholarship growth factor-beta (TGF-B) and the role of Wnt signalling in theof Wnt signalli

278802 Dr Yeesim Khew-Goodall A tyrosine An enzyme that regulates cell-cell adhesion, migration the epithelial-m

Institute of cell migration and and Science

NHMRC Project Grants Priming Grant (New Investigator) phosphatase that regulates adherens junctions, Medical and Veterinary morphog

298900 Dr Allison J Cowin Mechanisms of skin wound repair and scar formation

University formation

NHMRC Project Grants Standard Project Grant Function of the Flightless protein in wound repair and scarof Adelaidein skin

301137 Regulation of SNAREs and cytokine macrophages.

secretion of Queensland

A/Pr Jennifer L Stow NHMRC Project Grants Standard Project Grant LPS-regulated SNAREs and control of cytokine University in secretion.

334076 Dr Cynthia B Whitchurch Control of PseudomonasMonash University

aeruginosa virulence

NHMRC Project Grants Standard Project Grant Analysis of a chemosensory complex that controls twitching motility and virulence in Pseudo

351140 CD151 in epithelial biology and cancer

University of Newcastle

Prof Leonie K Ashman NHMRC Project Grants Standard Project Grant Role of the tetraspaninCD151, a cell surface protein that regulates cell migration and cance

351519 Dr Sheree E Cross Burns and antibiotic andUniversity pharmacokinetics

antibiotic of

NHMRC Project Grants Standard Project Grant Management of burn injury: Fluid dynamicspharmacokineticsQueensland

353645 Investigation of investigation of the first genetic risk factor

University factor for venous leg

Prof Michael C Stacey NHMRC Project Grants Standard Project Grant Susceptibility to venous leg ulceration: the first genetic riskof Western Australia ulcers

382903 An ancient gene family is essential for skin barrier deficient mice

Melbourne Health

A/Pr Stephen M Jane NHMRC Project Grants Standard Project Grant Defects in epidermal morphogenesis in mammalian Grainyhead-like geneformation, hair de

390100 A/Pr Zee Upton NHMRC Project Grants Development Grant Pre-clinical evaluation and optimisation of a novel therapy for burns

Queensland a topical of Technology

Pre-clinical assessment of novel growth factor complexes asUniversityagent in the treatmen

409902 Ms Leila Cuttle SCHOLARSHIP Treating Burn First-aid Burn injuries: First-aid and alternative therapies

University

Biomedical Postgraduate Scholarship injuries: Treating and alternative therapies of Queensland

436659 Dr Ian M Smyth The role Understanding Fraser and disease

Monash

NHMRC Project Grants Priming Grant (New Investigator)of the Frem proteins in development Syndrome University

437205 N Adrenergic receptors and pain

Murdoch

Prof Peter D Drummond HMRC Project Grants Standard Project Grant Involvement of adrenergic receptors in neuropathic pain University

446201 Prof Annemarie HennessyNHMRC Enabling Grants Enabling The National NHMRC Baboon Colony Alfred Hospital

The National NHMRC Baboon Colony Royal Prince

454693 migration by Scribble in University of Melbourne repair

Dr Patrick O Humbert NHMRC Project Grants Standard Project Grant Regulation of epithelialRole of Scribble in migration development and wound

456106 A/Pr Roy M Kimble Ice of ice water and ice?University of Queensland

NHMRC Project Grants Standard Project Grant First aid for burns: the use water for burn first aid?

457247 AWARDS

Dr Rachael Z Murray CAREER DEVELOPMENTBiomedical CDA The cell biology and immunology ofof Sydney

The cell biology and immunology of wound healing University wound healing

491130 NHMRC Project Grants Standard Project Grant Characterisation of extracellular DNases of Pseudomonas aeruginosa causes disease

A/Pr Cynthia B Whitchurch Monash University

How the bacterium Pseudomonas aeruginosa and their contribution

497266 Prof Zee Upton NHMRC Project Grants Development Grant Treatment for chronic novelQueensland University of Technology

Development and pre-clinical evaluation of a ulcers wound dressing treatment for chronic ul

497267 Prof Zee Upton NHMRC Project Grants Development Grant Dressings for Scar Remediation

Queensland University of Technology

Development and Pre-Clinical Evaluation of a Silicone Dressing for Scar Remediation

508097 Dr Stuart Pitson sphingosine kinase in wound healing healing

University of

NHMRC Project Grants Standard Project Grant The role of SKAM and Novel mechanisms controlling wound Adelaide

512179 Signalling mechanisms of a new and Sydney

University of epidermal growth

A/Pr Chris Jackson NHMRC Project Grants Standard Project Grant Activated protein C utilises protease activated receptorswound healing agent factor recept

512259 Integrin intracellular transport, expression and function in macrophages regulates inflamma

Dr Rachael Z Murray NHMRC Project Grants Priming Grant (New Investigator) University of Sydney

Adhesion receptors in the macrophage that regulate wound healing

513877 Evaluation of new complex for therapy for chronic venous leg ulc

University of Western Australia

Prof Michael C Stacey NHMRC Project Grants Standard Project Grant Evaluation a novel vitronectin:growthafactorgrowth factortreatment ofchronic venous leg ulce

State App Year Start Year 2000 2001 2002 2003 2004 2005 2006 2007

VIC 1999 2000 $101,037 $115,136 $121,275

VIC 1999 2000 $224,460 $129,730 $135,780 $137,655 $132,303

WA 2000 2001 $85,285 $85,621 $85,621

QLD 2000 2001 $75,380 $75,828 $75,828

QLD 2000 2001 $135,475 $136,035 $136,035

QLD 2000 2001 $155,665 $156,450 $156,450

VIC 2000 2001 $70,380 $70,828 $70,828

VIC 2000 2001 $95,380 $95,828 $95,828 $95,828 $105,828

NSW 2001 2002 $58,771 $109,338 $46,684 $18,375

VIC 2001 2002 $75,550 $70,440 $60,220

QLD 2002 2003 $28,432

NSW 2002 2003 $94,250 $94,250 $94,250

VIC 2002 2003 $130,588 $130,588 $130,588

NSW 2002 2003 $83,250 $83,250

NSW 2001 2003 $130,550 $130,550 $130,550

NSW 2002 2003 $28,432 $29,489 $30,014

SA 2003 2004 $165,500 $165,500 $165,500

SA 2003 2004 $164,250 $164,250 $144,250

QLD 2003 2004 $160,250 $155,250 $155,250

VIC 2004 2005 $118,750 $113,750 $113,750

NSW 2004 2005 $151,500 $151,500 $151,500

QLD 2004 2005 $114,125 $114,125 $114,125

WA 2004 2005 $107,000 $92,000 $92,000

VIC 2005 2006 $202,875 $207,291

QLD 2004 2005 $39,218 $117,653

QLD 2005 2006 $21,231 $21,866

VIC 2006 2007 $156,950

WA 2006 2007 $112,775

NSW 2006 2007 $120,000

VIC 2006 2007 $168,450

QLD 2006 2007 $70,175

NSW 2006 2007 $90,500

VIC 2007 2008

QLD 2007 2008

QLD 2007 2008

SA 2007 2008

NSW 2007 2008

NSW 2007 2008

WA 2007 2008



$ 325,497 $ 862,431 $ 1,011,966 $1,433,525 $ 1,293,162 $ 1,525,198 $ 1,278,134 $ 1,419,382

Broad Research Field Of Research Research

2008 2009 2010 2011 Total

Area Research KW 1 KW 2

$337,448 Nephrology

Clinical Medicine and Science and UrologyHB-EGF acute renal failure

$759,928 Basic Science angiogenesis endometrium

Obstetrics and Gynaecology

$256,527 Basic Science Actin cytoskeleton

Anti-cancer drugs

Protein Targeting and Signal Transduction

$227,036 Basic Science Cell adhesion Cell signaling

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)

$407,545 Basic Science P aeruginosa

Medical Bacteriology seudomonas fimbriae

$468,565 Basic Science Developmental biology

Endothelial cells

Genetic Development (incl. Sex Determination)

$212,036 Basic Science Dermatology epidermis keratinocyte stem cells

$488,692 Basic Science E Endothelium

Basic Pharmacology pithelium andInflammation

$233,168 Basic Science Array

Gastroenterology and Hepatology Fibrosis

$206,210 Therapies neurogenic inflammation and healing

Clinical Medicine and Science and Therapeutic Technology neuropathy

$28,432 Surgery

Clinical Medicine and Science Burns Children

$282,750 Nephrology DNA

Clinical Medicine and Science and Urology vaccination interstitial inflammatory cells

$391,764 Basic Science Dermatology epidermis epithelial morphogenesis

$166,500 Gastroenterology and Hepatology Leptin

Clinical Medicine and Science Fibrosis

$391,650 Dermatology

Clinical Medicine and Science gelatinase

activated protein C

$87,935 Basic Science Vision Science

Ophthalmology andApoptosis Cataract surgery

$496,500 Basic Science adherens junctions

cell-cell adhesion

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)

$472,750 Basic Science Dermatology cytoskeletal

conditional gene targeting components

$470,750 Basic Science SNARE proteins biology

cell

Protein Targeting and Signal Transduction

$346,250 Basic Science P aeruginosa

Medical Bacteriology seudomonas chemotaxis

$454,500 Basic Science cell migration epithelial biology

Oncology and Carcinogenesis

$342,375 Intensive Care

Clinical Medicine and Science Antibiotic tissue penetration

Antibiotic pharmacokinetics

$291,000 Surgery

Clinical Medicine and Science clinical research

chronic venous insufficiency

$211,491 $621,657 Basic Science Developmental biology morphogenesis

Epidermal

Genetic Development (incl. Sex Determination)

$156,871 Medical Biotechnology

Clinical Medicine and Science E

Epithelialisation xtracellular matrix protein

$22,257 $65,354 Surgery

Clinical Medicine and Science Burn First-aid

$160,200 $154,993 $472,143 Basic Science Cell Adhesion Extracellular

and growth factor signalling

Genetic Development (incl. Sex Determination)matrix

$115,078 $115,078 $342,931 Basic Science System neurotrauma

Peripheral Nervous adrenergic receptor

$120,000 $120,000 $120,000 $120,000 $600,000 Basic Science not elsewhere Gene therapy

classified

Medical Physiology Diabetes - retinopathy, nephropathy, wound healing

$171,950 $171,950 $512,350 Basic Science Drosophila melanogaster

cell migration

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)

$71,621 $66,414 $208,210 Surgery

Clinical Medicine and Science cell death/apoptosis

burn wound healing

$92,500 $92,500 $92,500 $92,500 $460,500 Basic Science Protein

Membrane Biology Cellular Interactions Targeting

$136,630 $136,630 $136,630 $409,890 Basic Science Infectious DiseasesBacterial pathogenBacterial virulence factors

$61,223 $61,223 $122,446 Basic Science skin venous

Clinical Sciences not elsewhere classified leg ulcers

$53,565 $80,348 $26,783 $160,696 Basic Science collagen synthesis remediation

elsewhere classified

Biochemistry and Cell Biology not scar down-regulation

$91,815 $91,815 $91,815 $275,445 Basic Science Cell Physiology cell migration cell proliferation

$77,880 $77,880 $77,880 $233,640 Basic Science delayed wound repair

elsewhere agent

Biochemistry and Cell Biology not therapeuticclassified

$141,735 $141,735 $141,735 $425,205 Basic Science Inflammation cell adhesion

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)

$123,420 $232,090 $232,090 $221,880 $809,480 Surgery

Clinical Medicine and Science clinical trial growth factor therapy



$ 1,651,365 $ 1,542,656 $ 919,433 $ 434,380 $ 13,697,129

Research Research Research Health Health Health Health Health Application

Unit Status

KW 3 KW 4 KW 5 KW 1 KW 2 KW 3 KW 4 KW 5 Status

ischaemia-reperfusion injury growth factor

growth factor-like signal

acute end-stage renal failure wound healing

heparin-binding epidermalnuclear localisationrenal failure trauma Payments can be made

Payments can be made

immunohistochemistry cancer cell growth factor

endothelial cell vascular endothelial endometriosis

embryo implantation Payments can be made

menorrhagiawound healing Payments can be made

Rac and Rho GTPase signalling

Nerve Tumour Wound

Cell motility and adhesion Tyrosine kinases regeneration metastasis healing Payments can be made

Payments can be made

Tyrosine phosphorylationCancer biology

Breast

E-cadherin Receptor tyrosine phosphatase disease Wound healing

Kidney disease Payments can be made

Payments can be made

infection

host colonisation cystic fibrosis

burns patients nosocomial infections Payments can be made

immunocompromised patients Payments can be made

Sox genes TranscriptionAngiogenesis

Molecular genetics factors Wound

Vascular disease healing Payments can be made

Payments can be made

skin gene therapy soriasis skin cancer wound healing

pluripotentiality biology tissue regeneration p Payments can be made

Payments can be made

cytoprotection enetically manipulated animals

Protease-activated receptors g Airway inflammation

Arthritis Wound

Vascular remodelinghealing Payments can be made

Payments can be made

Liver

Hepatic Stellate Cell Payments can be made

Payments can be made

electrical nerve stimulation

wound

non-invasive venous leg ulcers healing ageing impaired healing

chronic venous leg ulcers Payments can be made

peripheral neuropathy Payments can be made

Skin Trauma Wound healing Accepted Payments can be made

renal failurerenal interstitial scarring

nephrology proteinuria renal failure proteinuric renal disease vaccination Payments can be made

Payments can be made

mesenchymal signals

extracellular matrix dermatologyepithelial function healing

microenvironment wound Payments can be made

Payments can be made

Liver Obesity Wound healingHepatic fibrosis/cirrhosis

Hyperleptinemia

Obesity resistance Payments can be made

Type II diabetes/insulin Payments can be made

wound healing Payments can be made

Payments can be made

TransformingWound healing

Glaucoma surgery growth factor-beta Payments can be made

Payments can be made

protein localisation

tyrosine cancer

epithelial-mesenchymal transitionsphosphatase cardiovascular inflammationwound healing Payments can be made

Payments can be made

scar formation wound

transgenic animals healing wound healing andreepithelialsation

basic science wound scarring Payments can be made

Payments can be made

cytokine

cellular immunology secretion activation inflammation, cirrhosis, arthritis,disease wound healing can be made

macrophage infection/acute inflammation bowel psoriasis,

inflammatoryinflammatory mediatorsPayments Payments can be made

signal transduciton

type

protein interaction networks IV fimbriae cystic fibrosis

burns patients nosocomial infections Payments can be made

immunocompromised patients Payments can be made

metastases tetraspanin metastasis squamous carcinoma

invasion and membrane protein wound healing Payments can be made

Payments can be made

Protein extravasation Burn injury Burn resuscitation therapy

Burn injury and infection Wound fluid dynamics management Infection management Payments can be made

Payments can be made

vascular surgical research

leg ulcer wound healing deep risk factor

chronic leg ulcer vein thrombosis venous disease Payments can be made

Payments can be made

Gene

Gene expression targeting Neural tube closure

Hair development tubeSkin barrier formation

Neural defects Wound healing Payments can be made

Payments can be made

Wound healing

Growth factorPre-clinical assessment Payments can be made

Payments can be made

Scar Wound Healing Payments can be made

Payments can be made

Mouse models of diseaseEpidermal blistering

Renal and epidermal Fraser Syndrome Wound dysplasia

Inherited genetic disease (Fraser Syndrome) development Kidney agenesis andhealing Payments can be made

Payments can be made

sympathetic burn injury neuropathicpain transmission sensory neuropathy

nociception peripheral nerve injury nervous system pain painful Payments can be made

Payments can be made

in pregnancy Pharmakokinetics marrow transplantation

Bone

HypertensionOrgan transplantation/toleranceand aging Preeclampsia/eclampsia/ hypertension in pregnancy Payments can be made

Receptor mimetics

Diabetic neuropathy, wound healing Transplantation surgery be made

Payments can

cell polarity mouse genetics wound healing epithelial function

embryonic developmentmigration wound healing Payments can be made

Payments can be made

re-epithelialisation wound

burn injury cell survivalcooling burn first aid Payments can be

Payments can be made

inflammation: wound healing made

Signal Transduction Payments can be made

Payments can be made

Biofilms Pseudomonas aeruginosa Pneumonia burns

Host-pathogen interactionHospital acquired infection cystic fibrosisespiratory Accepted

r diseases Accepted

wound healing chronic leg or foot metalloproteinase wound repair

bisphosphonate matrix ulcerstissue regeneration Approved No Unit Found

silicones hypertropic keloid scarring

scarring

collagen synthesis down-regulation silicones Approved

tissue regeneration No Unit Found

wound

signalling pathways healing wound healing

cell growth cell signalling wound repair Accepted Payments can be made

wound healing protease skin wound

topical drug deliveryhealing Approved No Unit Found

cell migrationintegrins burns patients

membrane transport s

inflammationcar formation wound healing Accepted Payments can be made

skin wound

venous leg ulcers healing chronic leg or foot regenerationreepithelialisation

tissue ulcers wound wound repair Accepted Payments can be made

NHMRC FUNDED RESEARCH INTO BURNS, WOUNDS AND RELATED ISSUES 2000/01 TO 2007/08

Keywords: burns, scald, heat, caustic, friction, third degree, skin grafting, wound healing, pressure therapy, epidermal cells , dressing, adhesive elastic

bandage, cosmetic, partial thickness, scarring, cultured epithelial autograft , cultured cells, dermabrasion

Report Run: 4 June 2008

Source: Extracted from NHMRC research databases RMIS/GMS as at Jun 08

Summary Notes

1. This dataset contains the details of all NHMRC funded research grants that have been identified as having a connection with the research area of Burns,

wounds and related Issues through search of the Chief Investigator provided keyword and titles contained in the NHMRC research database. Relevance to the

research area in question may be either immediate or be a longer term perceived benefit. This dataset was current as at 4 June 2008 but is subject to change

over time.

Summary of Expenditure: Burns, Wounds and Related Issues

1999-00 $169,237 Actual Expenditure 2 grants

2000-01 $352,325 Actual Expenditure 4 grants

2001-02 $1,144,184 Actual Expenditure 9 grants

2002-03 $1,151,575 Actual Expenditure 14 grants

2003-04 $1,463,679 Actual Expenditure 18 grants

2004-05 $1,345,260 Actual Expenditure 15 grants

2005-06 $1,465,588 Actual Expenditure 15 grants

2006-07 $1,348,884 Actual Expenditure 16 grants

2007-08 $1,535,376 Actual Expenditure 19 grants

2008-09 $1,595,886 Forecast Expenditure 15 grants

Total $11,571,994 As at Dec 2008

2009-10 $1,231,043 Forward commitments 13 grants

2010-11 $676,907 Forward commitments 8 grants

2011-12 $217,190 Forward commitments 3 grants

Total $13,697,134 Incl out years

2 . Forward commitments funding data for out-years (ie beyond 2008) is subject to change when new grants are awarded in subsequent years





Grant Id CIA Grant Type Grant Subtype Scientific Title Simplified Title Admin Institutution

114408 Prof David A Power NHMRC Project Grants How does the kidney repair itself? Health

St. Vincent's

Standard Project Grant HB-EGF promotes recovery from experimental acute renal failure

124331 A/Pr Peter AW Rogers NHMRC Project Grants New Monash University

Research Fellowship Endometrial angiogenesis blood vessel growth in the human uterus

139021 Dr Robin M SCAIFE NHMRC Project Grants Signalling to the investigation

University of Western Australia

Standard Project Grant Regulation of signal transduction by Cbl: cytoskeleton of effects on the cytoskeleton, cell ad

142942 Dr Alpha S.K. Yap NHMRC Project Grants Receptor tyrosine phosphatase-E-cadherin signal complex

University of Queensland

Standard Project Grant Functional characterization of a signaling complex between receptor protein tyrosine phosp

143054 Prof John S. Mattick NHMRC Project Grants Pseduomonas aeruginosa infectionsQueensland

University of

Standard Project Grant Genetic dissection of the biogenesis and function of type IV fimbriae of Pseudomonas aeru

143061 Prof Peter A Koopman NHMRC Project Grants Control of blood vessel University of Queensland

development

Standard Project Grant Transcriptional control of blood vessel development by Sox18

145654 Dr Pritinder Kaur NHMRC Project Grants of murine keratinocyte stem cells

Standard Project Grant Developmental potentialSkin stem cell biology University of Melbourne

145828 A/Pr Thomas M Cocks NHMRC Project Grants Characterisation of inflammation towards knock-out mice

University of Melbourne

Research Fellowship Characterisation of PAR2 knockout and transgenic mice: in PAR2 gene therapy for epithelia

183770 CJ Martin Fellowship Differential gene expression in hepatic wound healing. hepatic woundCancer Medicine and

Dr Nicholas A Shackel Training Fellowship (Overseas) Centenary Institute of healing.

Differential gene expression in

195100 A/Pr Peteris J Darzins NHMRC Project Grants Using nerve stimulationNationalchronic leg wounds heal

to help Ageing Research Institute

Standard Project Grant Non-invasive electrical nerve stimulation to improve healing of chronic venous leg ulcers

243706 Dr John F Fraser SCHOLARSHIP Fetal wound ovine model for scarless wound recovery in burns patients

Royal model for scarless Brisbane

Medical Postgraduate Scholarship healing; anFetal wound healing; an ovineChildren's Hospital, wound recovery i

249414 Prof David CH Harris NHMRC Project Grants Treatment of disease with DNA vaccines vaccines against

The Children's Hospital at TCR subsets of

Standard Project Grant Treatment of chronic proteinuric renalkidney disease using specificagainst Westmeadinflame

251535 Dr Pritinder Kaur NHMRC Project Grants Factors affecting skin regeneration Melbourne

University of

Standard Project Grant Microenvironmental regulation of the tissue regenerative capacity of keratinocyte stem cells

253805 Dr Isabelle Leclercq NHMRC Project Grants Leptin and hepatic fibrosis

University of Sydney

Standard Project Grant Cellular and molecular mechanisms of the profibrogenic effect of leptin in the liver.

253855 NHMRC Project Grants

Dr Christopher J Jackson Development Grant promoter of wound healingUniversity of Sydney

Activated protein C as aActivated protein C to promote wound healing

258419 Dr Colin CW Chong SCHOLARSHIP Transforming Transforming growth the role of Wnt signalling in the of Wnt signa

University of Sydney

Medical Postgraduate Scholarship growth factor-beta (TGF-B) andfactor-beta (TGF-B) and the role resolution of

278802 Dr Yeesim Khew-Goodall NHMRC Project Grants A tyrosine that regulates adherens junctions, Medical and Veterinary morpho

Institute of cell migration and the epithelial-m

Priming Grant (New Investigator) phosphatase An enzyme that regulates cell-cell adhesion, migration andScience

298900 Dr Allison J Cowin NHMRC Project Grants Mechanisms of skin wound repair and scar formation

University formation

Standard Project Grant Function of the Flightless protein in wound repair and scarof Adelaidein skin

301137 A/Pr Jennifer L Stow NHMRC Project Grants and control of cytokine and cytokine Queensland

secretion of secretion.

Standard Project Grant LPS-regulated SNAREsRegulation of SNAREs University in macrophages.

334076 Dr Cynthia B WhitchurchNHMRC Project Grants Control of Pseudomonas aeruginosa virulence

Monash University

Standard Project Grant Analysis of a chemosensory complex that controls twitching motility and virulence in Pseudo

351140 Prof Leonie K Ashman NHMRC Project Grants CD151, a cell surface protein that of Newcastle migration and canc

University regulates cell

Standard Project Grant Role of the tetraspanin CD151 in epithelial biology and cancer

351519 Dr Sheree E Cross NHMRC Project Grants Burns and antibiotic pharmacokinetics

antibiotic of Queensland

Standard Project Grant Management of burn injury: Fluid dynamics andUniversity pharmacokinetics

353645 Prof Michael C Stacey NHMRC Project Grants leg ulceration: the first University first geneticAustralia

genetic risk Western risk factor

Standard Project Grant Susceptibility to venous Investigation ofinvestigation of the of factor for venous leg ulcers

382903 A/Pr Stephen M Jane NHMRC Project Grants An ancient gene familyMelbourne Health

is essential for skin gene formation, hair

Standard Project Grant Defects in epidermal morphogenesis in mammalian Grainyhead-likebarrierdeficient mice d

390100 A/Pr Zee Upton NHMRC Project Grants Development Grant of novel growth factor complexes asUniversity of Technology

Queensland a of a novel therapy treatmen

Pre-clinical assessment Pre-clinical evaluation and optimisationtopical agent in the for burns

409902 Ms Leila Cuttle SCHOLARSHIP Treating Burn Treating Burn injuries: therapies of Queensland

University

Biomedical Postgraduate Scholarship injuries: First-aid and alternative First-aid and alternative therapies

436659 Dr Ian M Smyth NHMRC Project Grants The role of Understanding Fraser Syndrome

Monash University

Priming Grant (New Investigator) the Frem proteins in development and disease

437205 N

Prof Peter D Drummond HMRC Project Grants Adrenergic receptors and pain

Murdoch

Standard Project Grant Involvement of adrenergic receptors in neuropathic pain University

446201 Prof Annemarie HennessyNHMRC Enabling Grants Enabling The National NHMRC Baboon Colony

The National NHMRC Baboon Colony Royal Prince Alfred Hospital

454693 Dr Patrick O Humbert NHMRC Project Grants Role of Scribble in migration

development and wound

Standard Project Grant Regulation of epithelial migration by Scribble in University of Melbourne repair

456106 A/Pr Roy M Kimble NHMRC Project Grants Ice water for burn first aid?

Standard Project Grant First aid for burns: the use of ice water and ice?University of Queensland

457247 AWARDS

Dr Rachael Z Murray CAREER DEVELOPMENT Biomedical CDA The cell of wound healing University of Sydney

The cell biology and immunologybiology and immunology of wound healing

491130 NHMRC Project Grants

A/Pr Cynthia B Whitchurch How the bacterium Pseudomonas aeruginosa causes contribution

Monash University

Standard Project Grant Characterisation of extracellular DNases of Pseudomonas aeruginosa and theirdisease

497266 Prof Zee Upton NHMRC Project Grants Development Grant Treatment for chronic ulcers

Queensland University of Technology

Development and pre-clinical evaluation of a novel wound dressing treatment for chronic ul

497267 Prof Zee Upton NHMRC Project Grants Development Grant Dressings for Scar a Silicone Dressing for Scar Remediation

Development and Pre-Clinical Evaluation ofRemediationQueensland University of Technology

508097 Dr Stuart Pitson NHMRC Project Grants Novel mechanisms controlling wound healing

University of

Standard Project Grant The role of SKAM and sphingosine kinase in wound healing Adelaide

512179 A/Pr Chris Jackson NHMRC Project Grants Signalling mechanisms Universitywound healinggrowth factor recep

of a new of epidermal agent

Standard Project Grant Activated protein C utilises protease activated receptors and Sydney

512259 Dr Rachael Z Murray NHMRC Project Grants Integrin intracellular transport, expression and the macrophage that regulate wound healing

Priming Grant (New Investigator) University of Sydney

Adhesion receptors in function in macrophages regulates inflamma

513877 Prof Michael C Stacey NHMRC Project Grants Evaluation of a new growth factor of Western chronic venous leg ul

University therapy of Australia

Standard Project Grant Evaluation a novel vitronectin:growth factor complex for treatment forchronic venous leg ulc

App Start

State 1999-00 2000-01 2001-02 2002-03 2003-04 2004-05 2005-06 2006-07

Year Year

VIC 1999 2000 $50,243 $106,488 $118,447 $62,270

VIC 1999 2000 $118,994 $168,004 $137,934 $131,188 $137,655 $66,152

WA 2000 2001 $42,643 $85,453 $85,621 $42,811

QLD 2000 2001 $113,294 $75,828 $37,914

QLD 2000 2001 $203,493 $136,035 $68,018

QLD 2000 2001 $233,890 $156,450 $78,225

VIC 2000 2001 $35,190 $70,604 $70,828 $35,414

VIC 2000 2001 $143,294 $95,828 $95,828 $100,828 $52,914

NSW 2001 2002 $122,050 $69,401 $41,717

VIC 2001 2002 $37,775 $72,995 $65,330 $30,110

QLD 2002 2003 $15,041 $13,391

NSW 2002 2003 $47,125 $94,250 $94,250 $47,125

VIC 2002 2003 $195,881 $130,588 $65,294

NSW 2002 2003 $124,875 $41,625

NSW 2001 2003 $65,275 $130,550 $130,550 $65,275

NSW 2002 2003 $15,041 $29,136 $29,752 $14,007

SA 2003 2004 $82,750 $165,500 $165,500 $82,750

SA 2003 2004 $82,125 $164,250 $154,250 $72,125

QLD 2003 2004 $80,125 $157,750 $155,250 $77,625

VIC 2004 2005 $59,375 $116,250 $113,750

NSW 2004 2005 $75,750 $151,500 $151,500

QLD 2004 2005 $57,063 $114,125 $114,125

WA 2004 2005 $153,000 $92,000

VIC 2005 2006 $101,438 $205,083

QLD 2004 2005 $98,044 $58,826

QLD 2005 2006 $11,616 $21,674

VIC 2006 2007 $78,475

WA 2006 2007 $56,388

NSW 2006 2007 $60,000

VIC 2006 2007 $84,225

QLD 2006 2007 $35,088

NSW 2006 2007 $45,250

VIC 2007 2008

QLD 2007 2008

QLD 2007 2008

SA 2007 2008

NSW 2007 2008

NSW 2007 2008

WA 2007 2008

$169,237.00 $352,325.00 $1,144,184.00 $1,151,575.00 $1,463,679.00 $1,345,260.00 $1,465,588.00 $1,348,884.00

Broad Research Field Of Research Research

2007-08 2008-09 2009-10 2010-11 2011-12 Total

Area Research KW 1 KW 2

$337,448 Nephrology

Clinical Medicine and Science and UrologyHB-EGF acute renal failure

$759,927 Basic Science angiogenesis endometrium

Obstetrics and Gynaecology

$256,528 Basic Science Actin cytoskeleton

Anti-cancer drugs

Protein Targeting and Signal Transduction

$227,036 Basic Science Cell adhesion Cell signaling

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)

$407,546 Basic Science P aeruginosa

Medical Bacteriology seudomonasfimbriae

$468,565 Basic Science Developmental biology

Endothelial cells

Genetic Development (incl. Sex Determination)

$212,036 Basic Science Dermatology epidermis keratinocyte stem cells

$488,692 Basic Science E Endothelium

Basic Pharmacology pithelium andInflammation

$233,168 Basic Science Array

Gastroenterology and Hepatology Fibrosis

$206,210 Therapies neurogenic inflammation and healing

Clinical Medicine and Science and Therapeutic Technology neuropathy

$28,432 Surgery

Clinical Medicine and Science Burns Children

$282,750 Nephrology DNA

Clinical Medicine and Science and Urology vaccination interstitial inflammatory cells

$391,763 Basic Science Dermatology epidermis epithelial morphogenesis

$166,500 Gastroenterology and Hepatology Leptin

Clinical Medicine and Science Fibrosis

$391,650 Dermatology

Clinical Medicine and Science gelatinase

activated protein C

$87,936 Basic Science Vision Science

Ophthalmology andApoptosis Cataract surgery

$496,500 Basic Science adherens junctions

cell-cell adhesion

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)

$472,750 Basic Science Dermatology cytoskeletal

conditional gene targeting components

$470,750 Basic Science SNARE proteins biology

cell

Protein Targeting and Signal Transduction

$56,875 $346,250 Basic Science P aeruginosa

Medical Bacteriology seudomonaschemotaxis

$75,750 $454,500 Basic Science cell migration epithelial biology

Oncology and Carcinogenesis

$57,063 $342,376 Intensive Care

Clinical Medicine and Science Antibiotic tissue penetration

Antibiotic pharmacokinetics

$46,000 $291,000 Surgery

Clinical Medicine and Science clinical research

chronic venous insufficiency

$209,391 $105,746 $621,658 Basic Science Developmental biology morphogenesis

Epidermal

Genetic Development (incl. Sex Determination)

$156,870 Medical Biotechnology

Clinical Medicine and Science E

Epithelialisation xtracellular matrix protein

$22,062 $10,004 $65,356 Surgery

Clinical Medicine and Science Burn First-aid

$158,575 $157,596 $77,496 $472,142 Basic Science Cell Adhesion Extracellular

and growth factor signalling

Genetic Development (incl. Sex Determination)matrix

$113,927 $115,078 $57,539 $342,932 Basic Science System neurotrauma

Peripheral Nervous adrenergic receptor

$120,000 $120,000 $120,000 $120,000 $60,000 $600,000 Basic Science not elsewhere Gene therapy

classified

Medical Physiology Diabetes - retinopathy, nephropathy, wound heal

$170,200 $171,950 $85,975 $512,350 Basic Science Drosophila melanogaster

cell migration

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)

$70,898 $69,018 $33,207 $208,211 Surgery

Clinical Medicine and Science cell death/apoptosis

burn wound healing

$91,500 $92,500 $92,500 $92,500 $46,250 $460,500 Basic Science Protein

Membrane Biology Cellular Interactions Targeting

$68,315 $136,630 $136,630 $68,315 $409,890 Basic Science Infectious DiseasesBacterial pathogenBacterial virulence factors

$30,611 $61,223 $30,611 $122,445 Basic Science skin venous

Clinical Sciences not elsewhere classified leg ulcers

$26,783 $66,956 $53,565 $13,391 $160,695 Basic Science collagen synthesis remediation

elsewhere classified

Biochemistry and Cell Biology not scar down-regulation

$45,908 $91,815 $91,815 $45,908 $275,446 Basic Science Cell Physiology cell migration cell proliferation

$38,940 $77,880 $77,880 $38,940 $233,640 Basic Science delayed wound repair

elsewhere agent

Biochemistry and Cell Biology not therapeuticclassified

$70,868 $141,735 $141,735 $70,868 $425,206 Basic Science Inflammation cell adhesion

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)

$61,710 $177,755 $232,090 $226,985 $110,940 $809,480 Surgery

Clinical Medicine and Science clinical trial growth factor therapy

$1,535,376.00 $1,595,886.00 $1,231,043.00 $676,907.00 $217,190.00 $13,697,134.00

Research Research Research Health Health Health Health Health Application

Unit Status

KW 3 KW 4 KW 5 KW 1 KW 2 KW 3 KW 4 KW 5 Status

ischaemia-reperfusion injury growth factor

growth factor-like signal

acute end-stage renal failure wound healing

heparin-binding epidermalnuclear localisationrenal failure trauma Payments can be made

Payments can be made

immunohistochemistry cancer cell growth factor

endothelial cell vascular endothelial endometriosis

embryo implantation Payments can be made

menorrhagiawound healing Payments can be made

Rac and Rho GTPase signalling

Nerve Tumour Wound

Cell motility and adhesion Tyrosine kinases regeneration metastasis healing Payments can be made

Payments can be made

Tyrosine phosphorylationCancer biology

Breast

E-cadherin Receptor tyrosine phosphatase disease Wound healing

Kidney disease Payments can be made

Payments can be made

infection

host colonisation cystic fibrosis

burns patients nosocomial infections Payments can be made

immunocompromised patients Payments can be made

Sox genes TranscriptionAngiogenesis

Molecular genetics factors Wound

Vascular disease healing Payments can be made

Payments can be made

skin gene therapy soriasis skin cancer wound healing

pluripotentiality biology tissue regeneration p Payments can be made

Payments can be made

cytoprotection enetically manipulated animals

Protease-activated receptors g Airway inflammation

Arthritis Wound

Vascular remodelinghealing Payments can be made

Payments can be made

Liver

Hepatic Stellate Cell Payments can be made

Payments can be made

electrical nerve stimulation

wound

non-invasive venous leg ulcers healing ageing impaired healing

chronic venous leg ulcers Payments can be made

peripheral neuropathy Payments can be made

Skin Trauma Wound healing Accepted Payments can be made

renal failurerenal interstitial scarring

nephrology proteinuria renal failure proteinuric renal disease vaccination Payments can be made

Payments can be made

mesenchymal signals

extracellular matrix dermatologyepithelial function healing

microenvironment wound Payments can be made

Payments can be made

Liver Obesity Wound healingHepatic fibrosis/cirrhosis

Hyperleptinemia

Obesity resistance Payments can be made

Type II diabetes/insulin Payments can be made

wound healing Payments can be made

Payments can be made

TransformingWound healing

Glaucoma surgery growth factor-beta Payments can be made

Payments can be made

protein localisation

tyrosine cancer

epithelial-mesenchymal transitionsphosphatase cardiovascular inflammationwound healing Payments can be made

Payments can be made

scar formation wound

transgenic animals healing wound healing andreepithelialsation

basic science wound scarring Payments can be made

Payments can be made

cytokine

cellular immunology secretion activation inflammation, cirrhosis, arthritis,disease wound healing can be made

macrophage infection/acute inflammation bowel psoriasis,

inflammatoryinflammatory mediatorsPayments Payments can be made

signal transduciton

type

protein interaction networks IV fimbriae cystic fibrosis

burns patients nosocomial infections Payments can be made

immunocompromised patients Payments can be made

metastases tetraspanin metastasis squamous carcinoma

invasion and membrane protein wound healing Payments can be made

Payments can be made

Protein extravasation Burn injury Burn resuscitation therapy

Burn injury and infection Wound fluid dynamics management Infection management Payments can be made

Payments can be made

vascular surgical research

leg ulcer wound healing deep risk factor

chronic leg ulcer vein thrombosis venous disease Payments can be made

Payments can be made

Gene

Gene expression targeting Neural tube closure

Hair development tubeSkin barrier formation

Neural defects Wound healing Payments can be made

Payments can be made

Wound healing

Growth factorPre-clinical assessment Payments can be made

Payments can be made

Scar Wound Healing Payments can be made

Payments can be made

Mouse models of diseaseEpidermal blistering

Renal and epidermal Fraser Syndrome

Inherited genetic disease (Fraser Syndrome) development Kidney agenesis andhealingWound dysplasia Payments can be made

Payments can be made

sympathetic burn injury neuropathicpain transmission sensory neuropathy

nociception peripheral nerve injury nervous system pain painful Payments can be made

Payments can be made

in pregnancy Pharmakokinetics marrow transplantation

Bone

HypertensionOrgan transplantation/toleranceand aging Preeclampsia/eclampsia/ hypertension in pregnancy Payments can be made

Receptor mimetics

Diabetic neuropathy, wound healing Transplantation surgery be made

Payments can

cell polarity mouse genetics wound healing epithelial function

embryonic developmentmigration wound healing Payments can be made

Payments can be made

re-epithelialisation wound

burn injury cell survivalcooling burn first aid Payments can be

Payments can be made

inflammation: wound healing made

Signal Transduction Payments can be made

Payments can be made

Biofilms Pseudomonas aeruginosa Pneumonia burns

Host-pathogen interactionHospital acquired infection cystic fibrosisespiratory Accepted

r diseases Accepted

wound healing chronic leg or foot metalloproteinase wound repair

bisphosphonate matrix ulcerstissue regeneration Approved No Unit Found

silicones hypertropic keloid scarring

scarring

collagen synthesis down-regulation silicones Approved

tissue regeneration No Unit Found

wound

signalling pathways healing wound healing

cell growth cell signalling wound repair Accepted Payments can be made

wound healing protease skin wound

topical drug deliveryhealing Approved No Unit Found

cell migrationintegrins burns patients

membrane transport s

inflammationcar formation wound healing Accepted Payments can be made

skin wound

venous leg ulcers healing chronic leg or foot regenerationreepithelialisation

tissue ulcers wound wound repair Accepted Payments can be made



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