CONgenital CORvitia

Document Sample
CONgenital CORvitia Powered By Docstoc
					                                                                                     CONgenital CORvitia


Project group                                                                                                                                                            Steering committee
B.J.M. Mulder, AMC Amsterdam                                                                                                                                             B.J.M. Mulder, chairman, ICIN
E.T. van der Velde, LUMC Leiden                                                                                                                                          E.T. van der Velde, LUMC Leiden
J.W.J. Vriend, ICIN                                                                             National registry and DNA-bank of adults                                 E.C.M. Mariman, AZM Maastricht
C.J.M. Engelfriet-Rijk, ICIN                                                                         with congenital heart disease                                       J.E. Speksnijder, Netherlands Heart Foundation
I. Harms, ICIN                                                                                          www.CONCOR.net                                                   F.J. Meijboom, EMC Rotterdam
H.D.M. Murk Jansen, ICIN                                                                                                                                                 H.W. Vliegen, LUMC Leiden
L.M. Roffel, ICIN                                                                                                                                                        G. Veen, VUMC Amsterdam
W. Hoekstra, ICIN                                                                                                                                                        P.G. Pieper, AZG Groningen
                                                                                                                                                                         H.W.M. Plokker, UMCU Utrecht
                                                                                                                                                                         A.P.J. van Dijk, UMC St. Radboud Nijmegen
                                                                                                       Inclusion results -                                               O. Daniëls, UMC St. Radboud Nijmegen
                                                                                                                                                                         J.L.M. Stappers, AZM Maastricht
                                                                                                                June 30, 2004
                                                                                                                                                                         J.G.P. Tijssen, AMC Amsterdam
 Number of Patients




                      4400
                      4000            Total Patients Included
                                      DNA obtained                                                                                                                                                      Tetralogy of Fallot
                                                                                                                                                                             590
                      3600                                                                                                                                                                              Aortic coarctation

                      3200                                                                                                              1032                                                            Aortic valvar stenosis
                                                                                                                                                                                                        Transposition of
                      2800                                                                                                                                                                              great arteries
                      2400                                                                                                                                                               413            Pulmonary
                                                                                                                                                                                                        valvar stenosis
                      2000                                                                                                                                                                              ASD II

                      1600                                                                                                                                                                              Marfan syndrome
                                                                                                                            93
                      1200                                                                                                  126                                                           343           VSD

                      800                                                                                                                                                                               ASD I
                                                                                                                                    151
                      400                                                                                                                                                                               Perimembranous VSD
                                                                                                                                          215                                      311
                         0                                                                                                                                                                              Subvalvar aortic stenosis
                             jan'02    apr'02    jul'02   oct'02   jan'03   apr'03   jul'03   oct'03   feb'04   jun'04                               219                   283                          Other diagnoses (<2%)
                                                                                                                Month                                              241

Figure 1. Number of patients included.
                                                                                                                         Figure 2. Most frequent main diagnoses.
               Table 1. Late complications in CONCOR patients and main
               diagnoses.
                                                                                                                           Events




               Main diagnosis         Number of patients                                           Percentage*                                       1,6%
                                                                                                                                    Aneurysm/
               Endocarditis                                                                                                         Dissection

               Tetralogy of Fallot           23                                                          3.9%
                                                                                                                                                     2,6%
               VSD                           15                                                          6.8%                          CVA/TIA

               Aortic valvar stenosis        11                                                          3.1%
               CVA/TIA                                                                                                                               3,3%
                                                                                                                               Endocarditis
               ASD II                        12                                                          4.9%
               Tetralogy of Fallot           10                                                          1.7%
               Aortic valvar stenosis         9                                                          2.6%                Hypertension
                                                                                                                                                     4,5%

               Arrhythmia
               Tetralogy of Fallot          135                                                         22.8%                                        18,9%
               Complete transposition                                                                                               Arrhythmias

               of great arteries            116                                                         37.2%
               ASD II                        74                                                         30.3%                                    0           100     200     300    400     500   600      700      800       900
                                                                                                                                                                                                        Number of patients
               Hypertension
               Aortic coarctation            79                                                         19.1%            Figure 3. Late complications.
               ASD II                        18                                                          7.4%
               Aortic valvar stenosis        18                                                          5.1%
               Aneurysma/dissection
               Marfan syndrome               34                                                         15.5%
               Aortic coarctation            12                                                         2.9%
               Aortic valvar stenosis         5                                                         1.4%
               * Percentage is the occurrence of this complication with patients with the
               specific main diagnosis.




                             Netherlands Heart Journal, Volume 12, Number 9, September 2004                                                                                                                      425

				
DOCUMENT INFO
Shared By:
Categories:
Tags:
Stats:
views:11
posted:11/2/2011
language:English
pages:1