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					                                      Ferrous Sulfate
 USE: Prevention and treatment of iron deficiency anemias; supplemental therapy for patients receiving                            Saccharomyces Boullardii
epoetin alfa                                                                                             USE: Promote maintenance of normal microflora in the gastrointestinal tract; used in
                                                                                                         management of bloating, gas, and diarrhea, particularly to decrease the incidence of diarrhea
                                                                                                         associated with antibiotic use
Mechanism: Iron is released from the plasma and eventually replenishes the depleted iron stores
in the bone marrow where it is incorporated into hemoglobin
                                                                                                         Mechanism: S. boulardii, a nonpathogenic live yeast probiotic, acts as temporary flora to help re-
                                                                                                         establish the normal gastrointestinal microflora. May also modulate the immune system by
Dosage:Infants and Children: Male 11-18 : 12 mg
                                                                                                         inducing cytokines and suppress pathogenic bacteria growth.
Adverse Reactions
Gastrointestinal: GI irritation, epigastric pain, nausea, diarrhea, dark stools, constipation
Genitourinary: Discoloration of urine (black or dark)                                                    Dosage Florastor® Kids: 250 mg twice daily (may vary by manufacturer)
Miscellaneous: Liquid preparations may temporarily stain the teeth
Effects: Hypersensitivity to iron salts or any component (see Warnings); hemochromatosis,                Adverse Rx: Gastrointestinal: Constipation, flatulence
hemolytic anemia                                                                                         Miscellaneous: Thirst
                                                                                                         Postmarketing and/or case reports: Fungemias
Interactions: Absorption of oral preparation of iron and tetracyclines are decreased when both of
these drugs are given together; concurrent administration of antacids and cimetidine may
                                                                                                         Interactions: Antifungal Agents: May diminish the therapeutic effect of Saccharomyces
decrease iron absorption; iron may decrease absorption of penicillamine, levothyroxine,                  boulardii. Exceptions: Butenafine; Butoconazole; Ciclopirox; Econazole; Gentian Violet;
methyldopa, and levodopa when given at the same time; response to iron therapy may be delayed
                                                                                                         Iodoquinol; Naftifine; Natamycin; Oxiconazole; Povidone-Iodine; Sertaconazole; Sulconazole;
in patients receiving chloramphenicol; concurrent administration of ≥200 mg vitamin C per 30 mg          Sulfanilamide; Terconazole; Tioconazole; Tolnaftate; Triacetin; Undecylenic Acid. Risk D: Consider
elemental iron increases absorption of oral iron; absorption of quinolones may be decreased due
                                                                                                         therapy modification
to formation of a ferric ion-quinolone complex




                                                                                                                              Zosyn (Piperacillin and Tazobactam)
                                        Eucerin (Urea)                                                   USE: Treatment of sepsis, postpartum endometritis or pelvic inflammatory disease, intra-
                                                                                                         abdominal infections, including appendicitis (complicated by rupture or abscess) and peritonitis;
USE: Urea is used topically in the treatment of dry skin. At concentrations of 10–30%, urea              uncomplicated or complicated infections involving skin and skin structures, the lower respiratory
promotes hydration of keratin and mild keratolysis in dry and hyperkeratotic skin. The drug              tract, and urinary tract caused by piperacillin-resistant, beta-lactamase-producing strains that
increases the uptake of water by the stratum corneum, giving it a high water-binding capacity.           are piperacillin/tazobactam susceptible. Tazobactam expands activity of piperacillin to include
Topically applied urea may also have an antipruritic effect. At high concentrations (e.g., 40%),         beta-lactamase producing strains of S. aureus, H. influenzae, B. fragilis, Klebsiella, E. coli, and
urea is a protein denaturant.                                                                            Acinetobacter. When piperacillin and tazobactam is used to treat nosocomial pneumonia caused
Adverse Effects                                                                                          by P. aeruginosa, combination therapy with an aminoglycoside is recommended.
When used in appropriate dosage, topically applied urea preparations have a low order of toxicity.       Mechanism of Action Inhibits bacterial cell wall synthesis by binding to one or more of the
Transient stinging may occur, especially when urea preparations are applied to the face or broken        penicillin-binding proteins; inhibits the final transpeptidation step of peptidoglycan synthesis in
or inflamed skin. Local irritation may also occur following topical application of urea.                 bacterial cell walls; tazobactam prevents degradation of piperacillin by binding to beta-lactamases
Precautions and Contraindications                                                                        Precautions Use with caution in patients requiring restricted salt intake, and in patients with
Topical preparations containing urea are intended for external use only. Topical urea preparations       renal impairment or pre-existing seizure disorder; dosage modification required in patients with
should be applied with caution to the face or broken or inflamed skin. Urea should not be used           impaired renal function
near the eyes.                                                                                           Adverse Reactions: Cardiovascular: Hypertension, hypotension, edema, chest pain, arrhythmia,
Some commercially available topical formulations of urea contain sulfites that may cause allergic-       tachycardia, cardiac arrest Central nervous system: Insomnia, headache, dizziness, agitation,
type reactions, including anaphylaxis and life-threatening or less severe asthmatic episodes, in         confusion, fever, anxiety, convulsions, confusion Dermatologic: Rash, pruritus, erythema
certain susceptible individuals. The overall prevalence of sulfite sensitivity in the general            multiforme, Stevens-Johnson syndrome, urticaria Endocrine & metabolism: Hypokalemia
population is unknown but probably low; such sensitivity appears to occur more frequently in             Gastrointestinal: Diarrhea, constipation, nausea, vomiting, dyspepsia, melena, abdominal pain,
asthmatic than in nonasthmatic individuals. Topical urea preparations should be discontinued if          pseudomembranous colitis Hematologic: Leukopenia, thrombocytopenia, neutropenia, decrease
local irritation or rash occurs during use.                                                              in hemoglobin/hematocrit, eosinophilia, prolonged prothrombin time, hemolytic anemia,
Infant Dosage: Amebiasis: Oral: 35-50 mg/kg/day in divided doses every 8 hours                           agranulocytosis Hepatic: Elevated AST, ALT, bilirubin; hepatitis, cholestatic jaundice
Other parasitic iUrea is applied topically as a cream or lotion. The moisturizing effect of urea may     Local: Phlebitis, pain, injection site reaction Otic: Tinnitus Renal: Elevated BUN and serum
be enhanced by applying the preparation to the skin while it is still moist after washing or             creatinine, interstitial nephritis, renal failure Respiratory: Dyspnea, rhinitis, pharyngitis
bathing. Urea is applied topically to the affected area 1–3 times daily or as directed by a              Miscellaneous: Hypersensitivity reactions, anaphylaxis
physician.                                                                                               Dosage: Children >40 kg and Adults: I.V.: 3.375 g (3 g piperacillin/0.375 g tazobactam) every 6
                                                                                                         hours; maximum dose: 16 g of piperacillin component/day
                                                                                                         Adults: Nosocomial pneumonia: I.V.: 4.5 g (4 g piperacillin/0.5 g tazobactam) every 6 hours for 7-
                                                                                                         14 daysInfant Dosage Zosyn® (piperacillin and tazobactam) is a combination product; each
                                                                                                         3.375 g vial contains 3 g piperacillin sodium and 0.375 g tazobactam sodium in a 8:1 ratio.
                                                                                                         Dosage recommendations are based on the piperacillin component.<6 months of age: I.V.: 150-
                                                                                                         300 mg of piperacillin component/kg/day in divided doses every 6-8 hours

				
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posted:11/1/2011
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