Subcellular Tissue
Gene/Protei Role in Transcript Localizatio Expression
AGI n Name Synonyms Pathway Activation Activity n Patterns
BIOSYNTHES
IS
Lipid, fatty-acid and
isoprenoid
biosynthesis; sterol
At1g76490 HMG1 F14G6_9 biosynthesis Ind by dark ER membrane All tissues
Lipid, fatty-acid and
isoprenoid
biosynthesis; sterol Young seedlings,
At2g17370 HMG2 biosynthesis ER membrane roots, inflorescences
Lipid, fatty-acid and
isoprenoid
biosynthesis; sterol
At5g27450 MVK F21A20_160 biosynthesis
Lipid, fatty-acid and
isoprenoid
biosynthesis; sterol
At1g31910 F5M6_9 biosynthesis
Lipid, fatty-acid and
isoprenoid
biosynthesis; sterol
At2g38700 biosynthesis
Lipid, fatty-acid and
isoprenoid
biosynthesis; sterol
At3g54250 F24B22_210 biosynthesis
Lipid, fatty-acid and
isoprenoid
biosynthesis; sterol
At5g16440 IDI1 MQK4_17 biosynthesis plastid, cytosol
Lipid, fatty-acid and
isoprenoid
biosynthesis; sterol
At3g02780 IDI2 IPP2, F13E7_28 biosynthesis plastid, cytosol
Lipid, fatty-acid and FPS1S--roots and
isoprenoid inflorescences;
biosynthesis; sterol FPS1L--
At5g47770 FPS1 MCA23_9 biosynthesis inflorescences
Lipid, fatty-acid and
isoprenoid
biosynthesis; sterol
At4g17190 FPS2 dl4630c biosynthesis inflorescences
Biosynthesis of Rep by fungal
derivatives of elicitor in
homoisopentenyl tobacco
pyrophosphate; suspension
At4g34640 SQS1 T4L20_220 Sterol biosynthesis cultures
T4L20_230;
farnesyl-
diphosphate
farnesyltransfera
se; FPP:FPP Biosynthesis of Rep by fungal
farnesyltransfera derivatives of elicitor in
se; and homoisopentenyl tobacco
squalene pyrophosphate; suspension
At4g34650 SQS2 synthetase Sterol biosynthesis cultures
Biosynthesis of
derivatives of
homoisopentenyl Microsomal-
pyrophosphate; bound in
At1g58440 F9K23_3 Sterol biosynthesis animal cells
Biosynthesis of
derivatives of
homoisopentenyl Microsomal-
pyrophosphate; bound in
At2g22830 Sterol biosynthesis animal cells
Biosynthesis of
derivatives of
homoisopentenyl Microsomal-
pyrophosphate; bound in
At4g37760 T28I19_40 Sterol biosynthesis animal cells
MLE8_6,
squalene Biosynthesis of
monooxygenase derivatives of
2 (squalene homoisopentenyl Microsomal-
epoxidase 2) pyrophosphate; bound in
At5g24140 SE2 (SE 2) Sterol biosynthesis animal cells
Biosynthesis of
derivatives of
homoisopentenyl Microsomal-
pyrophosphate; bound in
At5g24150 K12G2_2 Sterol biosynthesis animal cells
K12G2_4,
squalene Biosynthesis of
monooxygenase derivatives of
1,2 (squalene homoisopentenyl Microsomal-
epoxidase 1,2) pyrophosphate; bound in
At5g24160 (se 1,2) Sterol biosynthesis animal cells
At2g07050 ATCYC sterol biosynthesis
At3g45130 T14D3_70 sterol biosynthesis
At1g78970 ATLUP1 YUP8H12R_28 sterol biosynthesis
At1g78960 ATLUP2 YUP8H12R_27 sterol biosynthesis
At1g78950 ATLUP3 YUP8H12R_23 sterol biosynthesis
At1g78955 ATLUP4 sterol biosynthesis
At1g66960 ATLUP5 F1O19_14 sterol biosynthesis
At4g15340 ATPEN1 dl3715c sterol biosynthesis
At4g15370 ATPEN2 dl3730c sterol biosynthesis
At5g48010 ATPEN3 MDN11_9 sterol biosynthesis
At5g36150 ATPEN4 MAB16_10 sterol biosynthesis
At5g42600 ATPEN5 MFO20_1 sterol biosynthesis
At1g78500 ATPEN6 T30F21_16 sterol biosynthesis
Not registered
(At3g29255?) ATPEN7 sterol biosynthesis
vasculature, mature
leaves, young roots
and other regions
undergoing cellular
At5g13710 ATSMT1 MSH12_18 sterol biosynthesis expansion
At1g20330 ATSMT2-1 F14O10_5 sterol biosynthesis
At1g76090 ATSMT2-2 T23E18_40 sterol biosynthesis
68299.m04843,
At5g50375 CPI1 MXI22.9 sterol biosynthesis
At1g11680 ATCYP51 F25C20_17 sterol biosynthesis
At2g17330 sterol biosynthesis
early stages of
embryogenesis, but
tetracyclic and not cellularizing
pentacyclic endosperm; nearly
triterpenes uniform in globular
(cholesterin, and early heart stage
steroids and embryos;by mature
hopanoids) embryo only in
biosynthesis; sterol presumptive shoot
biosynthesis; meristem and root tip;
regulation of cell anters, ovules,
expansion and germinating
division; seedlings, shoot tips,
development-- root tips, actively
embryogensis and dividing or expanding
At3g52940 FACKEL, FK F8J2_111 meristem vascular tissues
At1g20050 T20H2_16 sterol biosynthesis
Rep by BL--
F16B3_21; delta feedback
7-sterol-C5- inhibition of
desaturase 1; sterol biosynthesis; BR
At3g02580 STE1 Dwarf7, DWF7 target gene biosynthesis
delta 7-sterol-
C5-desaturase
At3g02590 2 F16B3_22 sterol biosynthesis
At1g50430 Dwarf5, DWF5 F11F12_22 sterol biosynthesis
MPN9_6;
Dwarf1, DWF1; sterol biosynthesis;
Diminuto1, CABBAGE1, campesterol and
At3g19820 DIM1 CBB1 sitosterol synthesis
sterol metabolism--
At3g07020 F17A9_17 sterol glycosylation
sterol metabolism--
At1g43620 T10P12_7 sterol glycosylation
brassinosteroid
Uncloned SAX1 biosynthesis
AAC49264.1; brassinosteroid
At2g38050 DET2 Dwarf6, DWF6 biosynthesis
Rep by BL--
feedback
brassinosteroid inhibition of
biosynthesis; target BR Highest in apical
At3g50660 Dwarf4, DWF4 T3A5_40 gene biosynthesis shoots and siliques
MJJ3_9; Rep by BL--
CAA60793.1; feedback
Cabbage3, brassinosteroid inhibition of
CBB3; Dwarf3, biosynthesis; target BR
At5g05690 CPD DWF3; CYP90 gene biosynthesis
BR-6-oxidase,
BR6ox, brassinosteroid Highest is apical
At5g38970 BR6ox1 CYP85A1 biosynthesis shoots and siliques
BR-6-oxidase brassinosteroid Highest in apical
At3g30180 2, BR6ox2 CYP85A2 biosynthesis shoots
biosynthesis of
phenylpropanoids;
putative Rep by BL--
brassinosteroid feedback
biosynthetic inhibition of
ROTUNDIFOLI enzyme; target BR
At4g36380 A3, ROT3 C7A10_980 gene biosynthesis Highest in roots
brassinosteroid
metabolism--
inactivation; BR Ind by SA
At2g03760 F19B11.21 target gene and MeJA
AC003105;
CYP72B1; putative role in
PHYB brassinosteroid
ACTIVATION metabolism--
TAGGED inactivation; target
At2g26710 BAS1 SUPPRESSOR gene Ind by BL ubiquitous
BR Signaling
F23K16_30;
AAC49810.1;
BIN1; Rep by BL--
Cabbage2, Part of the BR feedback
CBB2; Dwarf2, receptor complex; inhibition of
At4g39400 BRI1 DWF2 target gene BR signaling PM ubiquitous
Negative regulator
of BR signaling
F28A21_120; through inhibitory
X94939; UCU1; phosphorylation of
brassinosteroid- ASK-eta; BR positive
insensitive 2, DWARF12, regulators BES1
At4g18710 BIN2 DWF12 and BRZ1 Rep by BL Suspensor
Increased
activity
following BR
treatment
because of
increased
protein
stability. In
the absence
of BR, BIN2
targets the
protein for
proteasome-
BK000396; mediated
AY093500; degradation Nuclear
bri1-EMS- DAA00023.1; via accumulation
suppressor 1, F18O14_4; Positive regulator of phosphorylati following BR
At1g19350 BES1 BZR2 BR signaling on treatment
Increased
activity
following BR
treatment
because of
increased
protein
stability. In
the absence
of BR, BIN2
targets the
protein for
proteasome-
mediated
degradation Nuclear
brassinazole via accumulation
resistant 1, AF494338; Positive regulator of phosphorylati following BR
At1g75080 BZR1 F9E10_7 BR signaling on treatment
F17M5_190;
somatic
embryogenesis
BRI associated receptor-like putative member of
receptor kinase kinase 3 the BR receptor
At4g33430 1, BAK1 (SERK3) complex PM ubiquitous
Hypothesized to
cleave a BR-
binding protein,
making it
competent to bind
BRI1 BR; such a protein-
suppressor BR complex would
dominant, then interact with
At4g30610 BRS1 F17I23_50 BRI1/BAK1 secreted?
Immediate early
gene; positive
regulator of BR
signaling? Possible
mechanism-- High throughout liquid-
transcriptional culture-grown
upregulation by BR seedlings, but highest
TRIP-1, TGF- may increase in roots; all organs in
beta receptor- protein translation; 35 day plants, but
interacting AAC62878.1; possible substrate highest in roots and
At2g46280 protein eIF3i of BRI1 Ind by BR flowers
Immediate early
gene; positive
regulator of BR High throughout liquid-
signaling? Possible culture-grown
mechanism-- seedlings, but highest
TRIP-1, TGF- transcriptional in roots; all organs in
beta receptor- upregulation by BR 35 day plants, but
interacting AAC629877.1; may increase highest in roots and
At2g46290 protein eIF3i protein translation Ind by BR flowers
AL132962; Rep by BR;
At3g61410 BRH1 F2A19_10 Ind by chitin
Ind by BR,
auxin, and
abiotic
stresses--
touch
darkness and
temperature;
transcriptiona
l activation to
all of these
signals is
Immediate early conferred 102
At5g57560 TCH4 MUA2_13 gene bp region
Other GSK3-
like genes
Probably negative
regulator of
meristem
proliferation and
positive regulator of
gynoecium
patterning--RNAi
leads to increase in
number of flower
meristems and periphery of the
X75432; perianth organs and inflorescence
F2P16_10; ASK- an altered meristem; flower
At5g26750 AtSK11 alpha gynoecium pattern meristem
Probably negative
regulator of
meristem
proliferation and
positive regulator of
gynoecium
patterning--RNAi
leads to increase in
number of flower
meristems and periphery of the
X75431; perianth organs and inflorescence
F10A16_14; an altered meristem; flower
At3g05840 AtSK12 ASK-gamma gynoecium pattern meristem
AL163792;
At5g14640 ASK-epsilon T15N1_130
Overexpression
leads to enhanced
salt and drought
tolerance; induces
salt-stress-
T2D23_8; responsive genes Ind by NaCL
X99696; ASK- and anthocyanin and ABA, but
At1g06390 AtGSK1 iota accumulation not KCl
Throughout the
At2g30980 ASKd-zeta X94938 embryo
T20K12_60;
At3g61160 ASK-beta AJ002280 Pollen
F6N23_11;
At4g00720 ASK-theta Y07822 Pollen
F21M12_23;
X79279; ASK-
At1g09840 AtK-1 kappa
F13D13.5;
At1g57870 ASK-delta AC079732
Signaling
Pathway Description Reference
3-hydroxy-3-
methylglutaryl
coenzyme A
reductase, HMGR
3-hydroxy-3-
methylglutaryl
coenzyme A
reductase, HMGR
mevalonate kinase,
MVK
putative 5-
phosphomevalonate
kinase, PMVK
putative mevalonate
diphosphate
decarboxylase,
MVDPD
putative mevalonate
diphosphate
decarboxylase,
MVDPD
isopentenyl
diphosphate (IPP):
dimethylallyl
diphosphate (DMAPP)
isomerase, IDI
isopentenyl
diphosphate (IPP):
dimethylallyl
diphosphate (DMAPP)
isomerase, IDI
Two RNAs from the
same gene: FPS1S--
farnesyl diphosphate
synthase (FPS);
FPS1L--mitochondrial
farnesyl diphosphate
synthase
farnesyl diphosphate
synthase (FPS)
squalene synthase
(SQS)--the first
committed step of
sterol formation
squalene synthase
(SQS)--the first
committed step of
sterol formation
putative squalene
epoxidase (squalene
monoxygenase)
putative squalene
epoxidase (squalene
monoxygenase)
putative squalene
epoxidase (squalene
monoxygenase)
putative squalene
epoxidase (squalene
monoxygenase)
putative squalene
epoxidase (squalene
monoxygenase)
putative squalene
epoxidase (squalene
monoxygenase)
2,3(S)-oxidosqualene-
cycloartenol cyclase;
cycloartenol synthase
putative cycloartenol
synthase
lupeol synthase
multifunctional
triterpene synthase
putative lupeol
synthase
putative lupeol
synthase
putative lupeol
synthase
putative pentacyclic
triterpene synthase
putative pentacyclic
triterpene synthase
putative pentacyclic
triterpene synthase
putative pentacyclic
triterpene synthase
putative pentacyclic
triterpene synthase;
cycloartenol synthase
putative pentacyclic
triterpene synthase;
putative
oxidosqualene cyclase
putative pentacyclic
triterpene synthase
S-adenosyl methionine-
cycloartenol-C24-
methyltransferase;
dwarf mutant
S-adenosyl methionine-
24-methylene lophenol-
C-24(24')-
methyltransferase
S-adenosyl methionine-
24-methylene lophenol-
C-24(24')-
methyltransferase
cyclopropyl sterol
isomerase (CPI)
obtusifoliol-14alpha-
demethylase (CYP51)
1
obtusifoliol-14alpha-
demethylase (CYP51)-
2
delta 8,14-sterol-delta
14-reductase; sterol C-
14 reductase; dwarf
mutant
delta 8-delta 7-sterol
isomerase; C-8,7
sterol isomerase
delta 7-sterol-C5-
desaturase 1; sterol-
C5-desaturase; dwarf
mutant
delta 7-sterol-C5-
desaturase 2; sterol-
C5-desaturase
delta 5,7-sterol-delta 7-
reductase; sterol
delta7 reductase;
dwarf mutant
delta 5-sterol-delta 24-
reductase
(isomerase); dwarf
mutant
UDP-glucose : sterol
glucosyltransferase
UDP-glucose : sterol
glucosyltransferase
Uncloned--
chromosome 1, lower
arm; ; dwarf mutant;
hypersensitive to ABA
and auxin
5-alpha-steroid
reductase; 3-oxo-5-
alpha-steroid 4-
dehydrogenase; dwarf
mutant
steroid 22-alpha-
hydroxylase; dwarf
BR mutant
C-23 steroid
hydroxylase;
cytochrome P450
BR 90A1; dwarf mutant
cytochromoe P450;
overlapping functions
with BR6ox2; likely
carrying out steps of
BR biosynthesis
downstream of DWF4
cytochromoe P450;
overlapping functions
with BR6ox1; likely
carrying out steps of
BR biosynthesis
downstream of DWF4
cytochrome P450;
mutant is defective cell
elongation and
reduced leaf
expansion, but
phenotype not rescued
BR with BRs
brassinosteroid
BR sulfotransferase
putative 26-
hydroxylase
inactivating BRs; a
cytochrome P450 that
serves as a control
point between multiple
photoreceptor systems
and brassinosteroid
BR signal transduction
leucine-rich repeat
BR receptor kinase
glycogen synthase
kinase (GSK)
BR 3/SHAGGY-like kinase
Dominant mutants
show constitutive BR
responses; insensitive
to brassinazole;
partially overlapping
BR function with BZR1
Dominant mutants
show BR
hyperresponse
phenotypes in the dark
and increased BR
biosynthesis feedback
inhibition in the light;
partially overlapping
function with BES1, a
close homologue; bri1
BR suppressor
leucine-rich repeat
receptor kinase; null
has a weak bri1
phenotype--semidwarf;
overexpression can
overcome weak bri1
allele phenotypes, but
not bri1 null allele
BR phenotypes
putative secreted
serine
BR carboxypeptidase
WD-repeat protein;
functional component
of the plant translation
initiation factor eIF3;
antisense makes a
dwarf plant with a BR
deficient/insensitive
BR phenotype
WD-repeat protein;
functional component
of the plant translation
initiation factor eIF3;
antisense makes a
dwarf plant with a BR
deficient/insensitive
BR phenotype
RING-H2; antisense
plants have thicker
inflorescence stems
and altered leaf
BR; chitin morphology
BR; auxin; Encodes a xyloglucan
abiotic stress endotransglycosylase
glycogen synthase
Flower kinase (GSK)
development 3/SHAGGY-like kinase
glycogen synthase
Flower kinase (GSK)
development 3/SHAGGY-like kinase
glycogen synthase
kinase (GSK)
3/SHAGGY-like kinase
Abiotic stress-- glycogen synthase
salt and kinase (GSK)
drought 3/SHAGGY-like kinase
glycogen synthase
kinase (GSK)
3/SHAGGY-like kinase
glycogen synthase
kinase (GSK)
3/SHAGGY-like kinase
glycogen synthase
kinase (GSK)
3/SHAGGY-like kinase
glycogen synthase
kinase (GSK)
3/SHAGGY-like kinase
glycogen synthase
kinase (GSK)
3/SHAGGY-like kinase