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Emory_CV_JENKINS

VIEWS: 6 PAGES: 11

									Andrew Jenkins, Ph.D.                                                                  Page 1


                        Emory University School of Medicine
                                Curriculum Vitae
                                                                           Revised July 1, 2008
1.     Andrew Jenkins

2.     1462 Clifton Rd. NE, Suite 420 Tel: 404 727 3910
       Atlanta GA, 30322              Fax: 404 712 2585

3.     email: ajenki2@emory.edu, andrew.jenkins@emoryhealthcare.org

4.     British Citizen, U.S. Permanent Resident

5a.    Assistant Professor (Tenure Track),
       Dept. Anesthesiology, Emory University School of Medicine
       Appointed: March 2003

5c.    Faculty Member, Graduate Division of Biological and Biomedical Sciences,
       Graduate School of Arts and Sciences, Emory University.
       Appointed: July 2006

6.     Previous Academic Appointments:

       2000 - 2003      Instructor, Departments of Pharmacology and Anesthesiology
                        Weill Medical College of Cornell University, New York, NY

10.    Education:

       1989 - 1991      B.Sc. (Hons.) Physics Imperial College London & University of London,
                        UK

       1991 - 1995      Ph.D. Biophysics, Imperial College London & University of London, UK
                        Advisors: Professors Nick P. Franks & Bill Lieb

11.    Postgraduate Training:

       1995 - 1998      Postdoctoral Research Assistant (RA-1a), Biophysics Dept.,
                        Imperial College London & University of London, UK

       1998 - 1999      Postdoctoral Research Associate, Dept. Anesthesia & Critical Care,
                        Univ. of Chicago, Chicago, IL

       1999 - 2000      Postdoctoral Research Associate, Dept. Anesthesiology,
                        Weill Medical College of Cornell University, New York, NY

13c.   Committee Memberships

       Research Committee, Dept. Anesthesiology, Member 2003 -, Chair 2008 -
       Electronic Education Committee, Dept. Anesthesiology, Member, 2004 –
       Task Force on Research, Dept. Anesthesiology, Member, 2007 –
       Neuroscience Initiative / Comprehensive Neuroscience Center (Research), Fall 2007-
       Neuroscience Ph.D. Training Program, Oral Qualifying Examination Committee 2008-
Andrew Jenkins, Ph.D.                                                              Page 2


14.   Consultancies / Advisory Boards

      NIH P01 GM04718 PI Eger: 2005 – (UCSF)
      NIH P01 GM058448 PI Miller: 2008 – (Harvard Univ. / Massachusetts General Hospital)
      NIH R01 GM064371 PI Trudell 2000 – 2004 (Stanford University)

15.   Editorships & Editorial Boards:

      Evaluation Board, F1000 Medicine, 2004-
      Editorial Board, PLoSONE, 2006-

16.   Manuscript Reviewer:

      Neuropharmacology, 2000-
      Journal of Neurochemistry, 2002-
      Journal of Neurophysiology, 2003-
      Biochemistry, 2003-
      Anesthesiology, 2003-
      Alcoholism: Clinical and Experimental Research, 2003-
      Molecular Pharmacology, 2004-
      Journal of Pharmacology and Experimental Therapeutics, 2004-
      Biochemical Pharmacology, 2004-
      Anesthesia & Analgesia, 2004-
      Neuroscience, 2005-
      PLoSONE 2006-
      Journal of Molecular Biology, 2006-
      Journal of Neuroscience, 2007-

17.   Honors & Awards

      1991    Associate of the Royal College of Science
      1991    Medical Research Council (UK) Postgraduate Studentship
      1995    Diploma of Imperial College
      1997    Royal Society (UK) Travel Award
      2000    WCBR Travel Fellow
      2005    USCIS Outstanding Professor

18.   Society Memberships

      Member of the Society for Neuroscience (1997-)
      Member of the Biophysical Society (2001-)

19.   Organization of National Conferences:

      Session Chair, Winter Conference for Brain Research: 2001, 2004
      Session Chair, American Society for Anesthesiologists Annual Meeting, 2008

20.   Research Focus:

      i. the molecular mechanisms of general anesthetics and synaptic inhibition
      ii. allosteric modulation of ion channel proteins
      iii. computational modeling of protein function
      iv. neuropharmacology of idiopathic hypersomnia
Andrew Jenkins, Ph.D.                                                                        Page 3


21b.    Patents (pending)

        US 61/036,047: Use of flumazenil for the treatment of hypersomnia

22ai.   Active Support:

        P.I., NIH (NIGMS) GM073959
        GABA(A) receptor modulation via the beta subunit
        R01, $1,258,365, 2006-2011

24b.    Formal Teaching - Training & Residency Programs:

        Director, Introductory Neuroscience Seminars NS570, Graduate Division of Biological
        and Biomedical Sciences, Emory University, 2007 -

        Faculty, Scientific Writing for Grants IBS522, Graduate Division of Biological and
        Biomedical Sciences, Emory University, 2007 -

        Lecturer, Cellular, Molecular, and Developmental Neuroscience IBS 514, Division of
        Biological and Biomedical Sciences, Emory University, 2007 -

        Lecturer, Cell Surface Receptors IBS701, Graduate Division of Biological and
        Biomedical, Sciences, Emory University, 2006 -

        Lecturer, Frontiers in Neuroscience, IBS530R, Graduate Division of Biological and
        Biomedical, Sciences, Emory University, 2006

        Lecturer, Anesthesiology Grand Rounds Conference, Emory University School of
        Medicine, 2003 -

        Lecturer, Ion Channels of Excitable Membranes, Neuroscience Program, Weill Graduate
        School of Medical Sciences of Cornell University, 2002

        Instructor, Foundations of Modern Pharmacology, Committee on Neurobiology,
        Pharmacology and Physiology, Division of Biological Sciences, University of Chicago,
        1998-9

24c.    Formal Teaching – other categories

        Lecturer, Allied Health Pharmacology BAHS 504, 506, Emory University School of
        Medicine, 2006 -

        Lecturer, Introduction To Pharmacology IBS 532, Graduate Division of Biological and
        Biomedical Sciences, Emory University, 2006-

25.     Supervisory Teaching

        a. Ph.D. Students:

        Current
        Kate O’Toole, Graduate Student, Graduate Program in Neuroscience, Emory University
Andrew Jenkins, Ph.D.                                                                 Page 4


25.   Supervisory Teaching (continued)

      b. Postdoctoral Fellows:

      Jason Derry Ph.D., Multidisciplinary Translational Cancer Research Center, U. Alberta
      Paul Garcia M.D., Ph.D., CA2 Resident, Dept. Anesthesiology, Emory University
      Sean O’Shea, Ph.D. Postdoctoral Fellow, Max-Planck-Institut für Hirnforschung, Frankfurt

      Current
      Carrie Williams Ph.D. Postdoctoral Fellow Dept. Anesthesiology, Emory University

      c. Residents:

      James Richardson M.D., ICU Fellow, Dept. Anesthesiology, Emory University
      Marc Azran M.D., Cardiac Fellow, Brigham & Women’s Hospital, Harvard Medical School

      Current

      Scott Kolesky, MD PhD, CA3 Resident, Dept. Anesthesiology, Emory University

      d. Other; Graduate Students Mentored:
      Thomas Kash, Postdoctoral Fellow, Vanderbilt University (Winder Lab)
      Claude Schofield, Postdoctoral Fellow, Stanford University (Huguenard Lab)

      d. Other; Undergraduate Students Supervised:
      Luke Sebel, MD, PhD candidate, Feinberg Sch. Med., Northwestern Univ. (Surmeier Lab)
      Martin Frank, Ph.D. candidate, Baylor University (Physics)

      Current
      James Sebel, BS candidate (Physics) Emory University
      Jarin Joyner, BS candidate (Chemistry) Oberlin College

      d. Other; Medical Students:
      Mark Lofye, CA2 Resident, Dept. Anesthesiology, Emory University

      d. Other; Rotating Graduate Students:

      Mark Porath, Grad. Student, Graduate Program in Neuroscience, Emory University
      Terrell Brotherton, Grad. Student, Graduate Program in Neuroscience, Emory University
      Kate O’Toole, Graduate Student, Graduate Program in Neuroscience, Emory University
      Charity Duran, Grad. Student, Graduate Program in Neuroscience, Emory University
      Stefanie Ritter, Grad. Student, Graduate Program in Neuroscience, Emory University

      Other; Faculty:
      Olga Lazar, Assistant Professor, Dept Anesthesiology, Emory University
Andrew Jenkins, Ph.D.                                                                          Page 5


26.    Lectureships (last 5 years only)

       Dept. of Anesthesia and Perioperative Care, UCSF, San Francisco, CA, 1999 - 2008
       Dept. Anesthesiology, Weill Medical College of Cornell Univ., New York NY 2000 - 2005
       Dept. Anesthesiology, Emory University School of Medicine, Atlanta GA, 2002
       Dept. Anesthesia & Critical Care, Univ. of Chicago, Chicago, IL, 2002
       Visiting Professor; Massachusetts General Hospital, Boston, MA, 2002
       Membrane Biology Conference; Vanderbilt University, Nashville, TN, 2002
       Dept. Anesthesiology, UCLA, Los Angeles, CA, 2002
       Department of Anesthesia, Stanford University School of Medicine, CA, 2002
       Visiting Professor, Texas Tech Univ. Health Sciences Center, TX, February 2004
       Visiting Professor, Smith College, Northampton MA, March 2004
       Neural & Behavioral Science, SUNY-Downstate, Brooklyn NY, November 2005
       Dept. Anesthesiology, Washington University, St. Louis MO, January 2006
       Frontiers in Neuroscience, Emory University, November 2006
       Grady Memorial Hospital, Atlanta GA, January 2007
       Children's at Egleston - Children's Healthcare of Atlanta, Atlanta GA, March 2007

27.    Conference Invitations

       New Horizons in Anesthesiology, Steamboat Springs, CO, 2003
       New Horizons in Anesthesiology, Cozumel, Mexico, 2003
       MAC2005 (Mechanisms of Anesthesia Conference), Nara, Japan, February 2005

28.    Other:

       Immigration Consultant to Outstanding Professor Candidates, ISSP, Division of Campus
       Life, Emory University

29.    Bibliography

29a.   Research Articles.

       23 papers total, cited 706 times. Articles 16 onwards have been published while an
       independent investigator at Emory. Papers #8 & #14 have each been cited more than
       100 times.

       1. Actions of general anaesthetics on serotonin 5-HT3 receptors in N1E-115
       neuroblastoma cells. British Journal of Pharmacology (1996) 117, 1507-1515.
       Jenkins A, Franks, NP & Lieb, WR [cited 56 times]

       2. Stereoselective effects of etomidate optical isomers on gamma-aminobutyric acid type
       A receptors and animals. Anesthesiology (1998) 88, 708-717.
       Tomlin SL, Jenkins A, Lieb WR & Franks NP [cited 60 times]

       3. Structural basis for the inhibition of firefly luciferase by a general anesthetic.
       Biophysical Journal (1998) 75(5), 2205-2211.
       Franks NP, Jenkins A, Conti E, Lieb WR & Brick P [cited 82 times]

       4. Effects of temperature and volatile anesthetics on GABAA receptors.
       Anesthesiology (1999) 90(2), 484-491.
       Jenkins A, Franks NP & Lieb WR [cited 30 times]
Andrew Jenkins, Ph.D.                                                                   Page 6


      5. Preparation of barbiturate optical isomers and their effects on GABA(A) receptors.
      Anesthesiology (1999) 90(6), 1714-22.
      Tomlin SL, Jenkins A, Lieb WR & Franks NP [cited 17 times]

      6. Agonist gating and isoflurane potentiation in the human -aminobutyric acid type A
      receptor determined by the volume of a second transmembrane domain residue.
      Molecular Pharmacology (1999) 56(5), 1087-1093.
      Koltchine VV, Finn SE, Jenkins A, Nikolaeva N, Lin A & Harrison NL [cited 57 times]

      7. Patch-clamp analysis of anesthetic interactions with recombinant SK2 subtype
      neuronal calcium-activated potassium channels.
      Anesthesia & Analgesia (2000), 90(3), 727-32.
      Dreixler JC, Jenkins A, Cao YJ, Roizen JD & Houamed KM [cited 9 times]

      8. Evidence for a Common Binding Cavity for Three General Anesthetics within the
      GABAA Receptor.
      Journal of Neuroscience (2001) 21(6): RC136, 1-4
      Jenkins A, Greenblatt EP, Bertaccini E, Faulkner HJ, Light A, Andreasen A, Viner A,
      Trudell JR & Harrison NL [cited 104 times]

      9. The general anesthetic potencies of a series of propofol analogues correlate with
      potency for potentiation of GABA current at the GABA A receptor but not with lipid
      solubility.
      Journal of Pharmacology and Experimental Therapeutics (2001) 297:338-351
      Krasowski MD, Jenkins A, Flood, PD, Kung AK, Hopfinger AJ & Harrison NL [cited 36
      times]

      10. Anesthetic properties of 4-iodopropofol: Implications for mechanisms of anesthesia.
      Anesthesiology (2001) 94:1050-1057
      Lingamaneni R, Krasowski MD, Jenkins A, Troung T, MacIver BM, Harrison NL. &
      Hemmings HC [cited 12 times]

      11. Volatile anesthetic action on GABAA receptors: contrasting effects of 1(S270) and
      2(N265) point mutations
      Neuropharmacology (2002) 42(3):337-45
      Nishikawa K, Jenkins A, Paraskevakis I & Harrison NL [cited 33 times]

      12. Tryptophan scanning mutagenesis in TM4 of the GABAA receptor 1 subunit:
      Implications for modulation by inhaled anesthetics and ion channel structure
      Neuropharmacology (2002) 43(5):669-678
      Jenkins A, Andreasen AE Trudell JR & Harrison NL [cited 27 times]

      13. The anesthetic bromoform is a positive modulator of the GABAA receptor.
      Brain Research (2003) 960(1-2):36-41
      Kash TL, Jenkins A & Harrison NL [cited 6 times]

      14. Coupling of agonist binding to channel gating in the GABAA receptor
      Nature (2003) 412:272-275
      Kash TL, Jenkins A, Trudell JR & Harrison NL [cited 118 times]

      15. The Effects of Isoflurane on GABAA Receptors Activated by Full and Partial Agonists
      Anesthesiology (2003) 98(2): 306-11
      Topf N, Jenkins A, Baron N & Harrison, NL [cited 16 times]
Andrew Jenkins, Ph.D.                                                                     Page 7


       16. A Highly conserved aspartic acid residue in the signature disulfide-loop of the alpha 1
       subunit is a determinant of gating in the glycine receptor.
       J. Biol.Chem (2003) 278(36):34079-83
       Schofield, CM, Jenkins A, & Harrison, NL [cited 30 times]

       17. A gain-of-function mutation in the GABAA receptor produces synaptic and behavioral
       abnormalities in the mouse
       Genes, Brain and Behavior (2005) 4:10–19
       Homanics G, Elsen FP, Jenkins A, Ferguson C, Sloat B, Yuditskaya S, Ying S-W,
       Goldstein PA, Kralic J, Morrow AL & Harrison NL [cited 7 times]

       18. Additive actions of sevoflurane and propofol on -aminobutyric acid receptor function
       Anesthesiology (2006) 104:1176-83
       Sebel LE, Richardson JE, Singh SP, Bell SV & Jenkins A [cited 5 times]

       19. A conserved tyrosine in the 2 subunit M4 segment is a determinant of -aminobutyric
       acid type A receptor sensitivity to propofol
       Anesthesiology, (2007) 107:412-8
       Richardson JE, Garcia PA, O'Toole KK, Derry MC, Bell SV & Jenkins A [cited once]
                                                                                          2+
       20. Molecular modeling and mutagenesis reveals a tetradentate binding site for Zn in
       GABA(A)  receptors and provides a structural basis for the modulating effect of the 
       subunit
       J Chem Inf Model (2008) 48:344-9
       Trudell JR, Yue ME, Bertaccini EJ, Jenkins A, Harrison NL

       21. General anesthetics have additive actions on three ligand gated ion channels
       Anesthesia & Analgesia (2008) 107 in press
       Jenkins A, Lobo IA, Gong D, Trudell JR. Solt K, Harris RA and Eger EI II

       22. Inhaled anesthetics do not combine to produce synergistic effects regarding MAC in
       rats.
       Anesthesia & Analgesia (2008) 107 in press
       Eger EI II, Tang M, Liao M, Laster M, Solt K, Flood P, Jenkins A, Raines DE, Hendrickx
       JFA, Shafer SL, Yasumasa T, Sonner JM

       23. Menthol shares general anesthetic activity and sites of action on the GABA A receptor
       with the intravenous agent, propofol
       European Journal of Pharmacology (2008) in press
       Watt EA, Betts BA, Kotey FO, Humbert DJ, Griffith TN, Kelly EW, Veneskey KC, Gil N,
       Rowan KC, Jenkins A, & Hall AC.

29e.   Book Chapters:

       1. Structural elements governing activation and modulation of GABAA receptors
       Jenkins A, Kash TL, Schofield CM, Trudell JR & Harrison NL
       In Mashimo T, Ogli K & Uchida I: Basic and Systemic Mechanisms of General
       Anesthesia. Amsterdam Elsevier B.V., 2005, pp 26-31.

29i.   Other; Meeting Abstracts:

       1.The stereoselective effects of etomidate on GABA A receptors and tadpoles. Society
       for Neuroscience Annual Meeting (1997)
       Tomlin, S.L., Jenkins, A., Lieb, W.R & Franks, N.P.
Andrew Jenkins, Ph.D.                                                                   Page 8


      2. The volume of a single amino acid residue controls gating and isoflurane sensitivity of
      a GABA-A receptor American Society of Anesthesiologists Annual Meeting (1999)
      Harrison, N.L., Koltchine, V.V., Nikolaeva, N., Lin, A. & Jenkins, A.

      3. Interactions of volatile anesthetics with recombinant mammalian brain SK2 potassium
      channels American Society of Anesthesiologists Annual Meeting (1999)
      Jenkins, A., Harrison, N.L. & Houamed, K.M.

      4. Actions of alcohols and general anesthetics on 5-HT3 receptors American Society for
      Biochemistry and Molecular Biology 1999 Fall Symposia: Ethanol and Cell Signalling.
      Jenkins, A., Franks, N.P. & Lieb, W.R.

      5. The sensitivity of a human GABAA recetor to isoflurane is determined by the volume of
      a single amino acid residue. Society for Neuroscience Annual Meeting (1999)
      Jenkins, A., Koltchine, V.V., Nikolaeva, N., Finn, S., Lin, A. & Harrison, N.L.

      6. Interaction of anesthetic agents with a recombinant mammalian neuronal SK
      potassium channel. Society for Neuroscience Annual Meeting (1999)
      Dreixler, J.C., Jenkins, A., Cao, Y.-J., Harrison, N.L. & Houamed, K.M.

      7. Multiple Mutations Are Required to Remove Chloroform Sensitivity from GABA A
      Receptors American Society of Anesthesiologists Annual Meeting (2000)
      Harrison, N.L., Andreason, A.E., Viner, A., Light A. & Jenkins A.

      8. Halothane and Isoflurane Have a Common Site of Action on GABA A Receptors
      American Society of Anesthesiologists Annual Meeting (2000)
      Jenkins, A., & Harrison, N.L.

      9. A tryptophan scan in the TM-IV domain of the GABAA receptor reveals further amino
      acids critical for receptor and inhaled anesthetic modulation Society for Neuroscience
      Annual Meeting (2000) Jenkins, A., Andreasen, A.E. & Harrison, N.L.

      10. Multiple “cut-offs” define the volume of an anesthetic binding cavity in the GABA A
      receptor Society for Neuroscience Annual Meeting (2000) Harrison, N.L., Bertaccini, E.,
      Light, A., Viner, A., Andreasen, A.E., Trudell, J.R. & Jenkins, A.

      11. GABA receptors as anesthetic targets: What we’ve learned from gene and ion
      channel structure/function studies Winter Conference for Brain Research (2001)
      Jenkins, A., Homanics, G., Mihic, S.J., Weiss, D.S. & Cjazkowski, C.M.

      12. A tryptophan scan in TM4 reveals further residues critical for GABAA receptor function
      Mechanisms of Anesthetic Action Congress (2001)
      Jenkins, A., Andreasen, A. & Harrison, N.L.

      13. Inhaled anesthetic action on the GABAA receptor: contrasting effects of a and b
      subunit mutations American Society of Anesthesiologists Annual Meeting (2001)
      Nishikawa, K., Jenkins A., Paraskevakis I. & Harrison N.L.

      14. Residues in the TM4 segment of the GABAA receptor a subunit are critical for ion-
      channel gating and receptor modulation by inhalational anesthetics
      American Society of Anesthesiologists Annual Meeting (2001)
      Jenkins, A., Andreasen, A.E. & Harrison, N.L.

      15.Repairing a gating defect in a mutant GABAA receptor
      American Society of Anesthesiologists Annual Meeting (2001)
      Topf, N., Jenkins, A., Paraskevakis, I. & Harrison, N.L.
Andrew Jenkins, Ph.D.                                                                    Page 9


      16. A comparative study of GABAA receptor 1 Ser270 and 2 Asn265:               Anesthetic
      binding sites or critical transduction residues?
      Molecular Mechanisms of Alcohol and Anesthetic Action (2001)
      Jenkins A., Nishikawa, K., Paraskevakis I. & Harrison N.L.

      17.Actions of propofol analogs on GABAA receptors and animals: Results of 4D-QSAR
      analyses Society for Neuroscience Annual Meeting (2001)
      Krasowski, M.D., Jenkins, A., Rezac, M., Hopfinger, A.J. & Harrison N.L.

      18. Repairing a gating defect in a mutant GABAA receptors
      Society for Neuroscience Annual Meeting (2001)
      Topf, N., Jenkins, A., Paraskevakis, I. & Harrison, N.L.

      19. Volatile anesthetic action on GABAA receptors: contrasting effects of 1(S270) and
      2(N265) point mutations
      Society for Neuroscience Annual Meeting (2001)
      Nishikawa, K., Jenkins A., Paraskevakis I. & Harrison N.L.

      20. Docking of anesthetics to a GABA receptor model reproduces in vitro potency order
      American Society of Anesthesiologists Annual Meeting (2001)
      Bertaccini, E.J., Trudell, J.R., Jenkins, A. & Harrison, N.L.

      21. Interactions between the extracellular and transmembrane doamians of the GABA AR
        th
      12 Neuropharmacology Conference: GABAA Receptors in Network and Cellular
      Excitability (2002). Kash, T.K., Jenkins A., Ruscito, B., Trudell, J.R. & Harrison, N.L.

      22. Tryptophan scanning mutagenesis in TM4 of the GABAA receptor a1 subunit:
      Implications for modulation by inhaled anesthetics and ion channel structure
        th
      12 Neuropharmacology Conference: GABAA Receptors in Network and Cellular
      Excitability (2002). Jenkins, A., Andreasen, A., Trudell, J.R. & Harrison, N.L.

      23. Mutagenesis and Equilibrium Modeling Studies Provide Insights into Ion-Channel
      Function and General Anesthetic Action
      American Society of Anesthesiologists Annual Meeting (2003)
      Sebel LE, Frank M, Bell S & Jenkins A

      24. Asp148 in the Signature Disulfide-Loop couples ligand binding to channel opening in
      the Glycine Receptor a1 Subunit
      Society for Neuroscience Annual Meeting (2003)
      Schofield CM, Harrison NL & Jenkins A

      25. Reversing Consciousness
      Winter Conference for Brain Research (2004)
      Jenkins A, Homanics G, Nelson, LE, Pearce RA & MacIver MB

      26. Additive Effects of Sevoflurane and Propofol on GABA(A) Receptor Function
      American Society of Anesthesiologists Annual Meeting (2004)
      Jenkins A

      27. Multiple actions of propofol on cultured rat cerebellar Purkinje neurons
      Society for Neuroscience Annual Meeting (2004)
                           2                            2                          1
      Tracy O’Leary Ph.D. , Elizabeth E. Finch Ph.D. and Andrew Jenkins Ph.D. *
Andrew Jenkins, Ph.D.                                                                  Page 10


      28. A Glutamic Acid Residue Adjacent to the GABA Binding Site is Important for Agonist
                                        th
      Efficacy at the GABAA Receptor 7 International Conference on Basic and Systemic
      Mechanisms of Anesthesia, Nara, Japan (2005) Martin Frank, Jason M.C. Derry, Maria-
      Johanna Dizon, Neil L. Harrison, James R. Trudell & Andrew Jenkins

      29. Propofol Sensitivity of the GABA(A) Receptor Is Determined by a Conserved Tyrosine
      in the TM4 Domain of the beta2 Subunit (A104)
      American Society for Anesthesiologists Annual Meeting (2005)
      James E. Richardson, M.D., Jason M.C. Derry, Ph.D., Andrew Jenkins, Ph.D.

      30. Multiple Actions of Propofol on Cerebellar Cultures of Purkinje Neurons (A134)
      American Society for Anesthesiologists Annual Meeting, Atlanta GA (2005)
      Paul S. Garcia, Tracy O'Leary, Shannon Bell, Elizabeth A. Finch, Andrew Jenkins.

      31. Mutation of an isoleucine in the extracellular domain of the GABAA receptor 2
      subunit abolishes directactivation by pregnanolone (488.10)
      Society for Neuroscience Annual Meeting, Washington DC, (2005)
      J.M.C.Derry*; A.Jenkins

      32. Response surface modeling reveals additive actions of propofol and sevoflurane on
      GABAA receptors (488.16)
      Society for Neuroscience Annual Meeting, Washington DC, (2005)
      L.E.Sebel, J.Richardson, A.Jenkins*

      33. An extracellular domain of the GABAA receptor 2 subunit controls direct activation
      American Society for Anesthesiologists Annual Meeting, Chicago IL (2006)
      J.M.C.Derry*; A.Jenkins

      34. Propofol Sensitivity of the GABA(A) Receptor Is Determined by a Conserved Tyrosine
      in the TM4 Domain of the beta2 Subunit (A104)
      Society for Neuroscience Annual Meeting, Atlanta GA, (2006)
      JE Richardson, PA Garcia, JMC Derry & A Jenkins*

      35. Both Halothane and Chloroform Exhibit a Synergistic Relationship with GABA on the
      GABA(A) Receptor
      American Society for Anesthesiologists Annual Meeting, Chicago IL (2007)
      Richardson JE & Jenkins A

      36. A Conserved H-Bond Donor in the GABA(A) Receptor β2 Subunit M4 Segment
      Controls Propofol Sensitivity
      American Society for Anesthesiologists Annual Meeting, Chicago IL (2007)
      Garcia PS & Jenkins A

      37. Comparison of global optimization methods for kinetic rate constant estimation
      Society for Neuroscience Annual Meeting, Atlanta GA, (2007)
      Williams CA & Jenkins A

      38 Propofol enables "supramaximal" currents in mutant GABAA receptors
      Society for Neuroscience Annual Meeting, Atlanta GA, (2007)
      O’Shea SM & Jenkins A

      39. Inherited human epilepsy mutations differentially effect inhaled and intravenous
      general anesthetic action on GABA(A) receptor function
      Society for Neuroscience Annual Meeting, Atlanta GA, (2007)
      O’Toole KK & Jenkins A
Andrew Jenkins, Ph.D.                                                            Page 11


      40. Flumazenil selectively inhibits potentiation of volatile anesthetics
      American Society for Anesthesiologists Annual Meeting, Orlando FL (2008)
      Azran M & Jenkins A

      41. Direct activation of the GABAA receptor by GABA, propofol and pregnanolone is
      altered by point mutations in Loop F of the 2 subunit
      Society for Neuroscience Annual Meeting, Washington DC, (2008)
      Williams, CA & Jenkins A

								
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