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Creation of new In vivo experimental murine model of complete human adaptive immune function for the design and the preclinical evaluation of vaccine candidates

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Creation of new In vivo experimental murine model of complete human adaptive immune function for the design and the preclinical evaluation of vaccine candidates Powered By Docstoc
					PASTEUR LECTURE SERIES
A seminar entitled

‘Creation of new In vivo experimental murine model of complete human adaptive immune function for the design and the preclinical evaluation of vaccine candidates’
will be given by

Dr Yuchun LONE Institut Pasteur, France
Date: Time: Venue: Monday, 28 February 2005 11:00 am -12:00 noon Seminar Room 6, LG1/F., Laboratory Block HKU, Faculty of Medicine Building 21 Sassoon Road, Pokfulam, Hong Kong hkuip@hkusua.hku.hk or Anne Li at +852 2816 8403

Contact:

The seminar will describe the creation of first transgenic mouse that lacks murine MHC class I and class II molecules, and instead expresses human HLA class I and class II molecules. These mice enable a simultaneous evaluation, in every mouse tested, of the three adaptative components (help/TCD4+, cytolysis/TCD8+ and antibody/B lymphocytes) of « human like » immune response to antigens. Remarkably, the responses documented against hepatitis envelope are directed at the same T-epitope than the responses of HBV naturally infected or vaccinated humans expressing the same HLA molecules. Therefore, these mice authorize to perform protection assays. The novelty of the presented study lies in the fact that it is based on a completely humanized experimental animal model, which will facilitate investigation on basic and applied aspects of human Immunology. These mice provide a unique system for studying the immune response that allows the simultaneous evaluation of cytolytic, helper and antibody responses to immunogenic antigens of direct relevance for humans. These mice also raise the possibility to study cooperation between human HLA-restricted CD8+ T cell and HLA-restricted CD4+ T cells in the total absence of interference from murine responses (in “classic HLA transgenic mice”, the influence of murine-restricted responses modify qualitatively the human HLA-restricted responses, which compromise the predictive capacity for human responses in experimental model).
Sponsors:

I/F, Dexter HC Man Building, 8 Sassoon Road, Pokfulam, Hong Kong tel. : (852) 2816 8403 fax : (852) 2872 5782 e-mail : hkuip@hkusua.hku.hk

ALL ARE WELCOME


				
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