BIOGRAPHICAL SKETCH (PAN, DIPANJAN)
NAME: Dipanjan Pan POSITION TITLE:
eRA COMMONS USER NAME: DIPANJANPAN Research Assistant Professor of Medicine
Washington University in St. Louis
Education/training
INSTITUTION AND LOCATION (MENTORS) DEGREE YEAR FIELD
Vidyasagar University, India MS 1997 Organic Chemistry
Indian Institute of Technology, Kharagpur, India PhD 2002 Synthetic Chemistry
Washington University in St. Louis (Department of Chemistry) Postdoc 2002-05 Polymer Chemistry,
Nanotechnology
B. Positions and Honors
PERIOD TITLE INSTITUTION
1998-2000 Junior Research Scholar Indian Institute of Technology, Kharagpur, India
2000-2002 Senior Research Scholar Indian Institute of Technology, Kharagpur, India
2002-2005 Postdoctoral Research Associate Washington University in Saint Louis, MO
2005-2006 IP Analyst General Electric Global Research, Biosciences, Bangalore
2006-2006 Diploma on Patent and litigation Won, Central Board of GO, Hague, NL
2006-2007 Postdoctoral Research Associate Washington University in Saint Louis, MO
08/07–06/10 Research Instructor of Medicine Division of Cardiology, Washington Univ School of Medicine
07/10- Research Assistant Professor of Division of Cardiology, Washington Univ School of Medicine
Medicine
Selected Honors and Fellowship Awards
2010- MO-Life Pilot project grant (St. Louis Institute of Nanomedicine), 2010-2011
2010- Best paper award, St. Louis Institute of Nanomedicine, 2010
2010- Editorial board member, J of Biotechnology and Biomaterials
2009- Scientific Advisory Board Member, Lifeboat Foundation
2009- Editorial board member, World Journal of Radiology
2008- National Scientists Development Grant (American Heart Association) 2008-2012
2008- Reviewer /Referee for journals from Institute of Physics, American Chemical Society, Royal
Society of Chemistry, Wiley Interscience
2008- Elected member, Sigma XI, The scientific research society
2008- Associate Research Member, Siteman Cancer Center for Nanotechnology Excellence; WUSM
2006- Corporate Awards: Management Award: GE Global Research, JFWTC
2001-02 CSIR, India senior research fellowship
1998-01 Indian Institute of Technology Junior Research Fellowship
US Issued and Pending Patents
1. Becker ML, Fang H, Li X, Pan D, Rossin R, Sun X, Taylor JS, Turner JL, Welch MJ, Wooley KL. Cell
permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids ("PNAs") with
uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of
cancer. Washington University. (2006) US Pat No. 2006159619.
2. Lanza GM, Wickline, SA, Pan D, “Water Soluble Nano-Bialys: A Vascularly Constrained, Slow
Releasing Nano-carrier for Therapeutic Imaging” (2007) US provisional 60/978,679, 10-9-07.
WO2009049083.
3. Lanza GM, Wickline, SA, Pan D, “Particles for Imaging (Hard Particle Filing)” (2007) US provisional
60/980,955, 10-19-07. WO 2009049089
4. Lanza GM, Wickline, SA, Pan D, “Particles for Imaging (Soft Particle Filing)” (2007) US provisional
60/981,192, 10-19-07. WO 2009049089
5. Lanza GM, Wickline, SA, Senpan A, Pan D, “Development of colloidal iron oxide contrast agent for
magnetic resonance imaging (MRI) and magnetic particle imaging (MPI)” (2007) US provisional
60/978,678, 10-9-07. WO 2009049089
C. 15 Recent peer-reviewed publications (selected from 35 peer-reviewed journal articles)
1. Pan D, Roessl E, Scholmka J, Caruthers SD, Senpan A, Scott MJ, Allen JS, Zhang H, Hu G, Gaffney PJ,
Choi ET, Rasche V, Wickline SA, Proksa R, Lanza GM. Computed Tomography in Color: NanoK-
enhanced Spectral CT Molecular Imaging. Angew. Chem. Int. Ed. 2010 (in press)
2. Pan D, Caruthers SD, Senpan A, Schiemeder AH, Wickline SA, Lanza GM: Revisiting an old friend:
manganese-based MRI contrast agents. Nanomedicine and Nanobiotechnology, 2010 (in press).
3. Pan D, Caruthers SD, Chen J, Winter PM, Senpan A, Schiemeder AH, Wickline SA, Lanza GM:
Nanomedicine strategies for molecular targets with MR and optical imaging. Future Med. Chem. March
2010, 2(3), 471-490.
4. Pan D, Pramanik M, Senpan A, Ghosh S, Wickline SA, Wang LV, Lanza GM: Near infrared photoacoustic
detection of sentinel lymph nodes with gold nanobeacons. Biomaterials 2010, 31, 4088-4093.
5. Pan D, Williams TA, Senpan A, Allen JS, Scott MJ, Gaffney PJ Wickline SA, Lanza GM: Detecting
Vascular Biosignatures with a Colloidal, Radio-Opaque Polymeric Nanoparticle. J. Am. Chem. Soc., 2009;
131(42), 15522–15527.
6. Senpan A, Caruthers SD, Rhee I, Mauro NA, Pan D, Hu G, Scott MJ, Fuhrhop RW, Gaffney PJ, Wickline
SA, Lanza GM. Conquering the dark side: colloidal iron oxide nanoparticles. ACS Nano. 2009;3(12), 3917-
26.
7. Pan D, Pramanik M, Senpan A, Yang X, Song KH, Scott MJ, Zhang H, Gaffney PJ, Wickline SA, Wang
LV, Lanza GM: Molecular Photoacoustic Tomography with Colloidal Nanobeacons. Angew. Chem. Int. Ed.,
2009, 121 (23), 4243-4237.
8. Pan D, Senpan A, Caruthers SD, Williams T, Scott MJ, Gaffney PJ, Wickline SA, Lanza, GM: Sensitive
and efficient detection of thrombus with fibrin-specific manganese nanocolloids. Chemical
Communications. 2009, 3234-3236.
9. Pan D, Lanza, GM Wickline SA Caruthers SD: Nanomedicine: Perspective and promises with ligand-
directed molecular imaging. Eur. J. Radiol. 2009; 70(2), 274-285.
10. Pan D, Caruthers SD, Hu G, Senpan A, Scott MJ, Gaffney PJ, Wickline SA, Lanza, GM: Ligand-directed
Nanobialys as Theranostic Agent for Drug Delivery and Manganese based Magnetic Resonance Imaging
(MRI) of Vascular Targets. J. Am. Chem. Soc., 2008; 130 (29): 9186–9187.
11. Rossin R, Pan D, Qi K, Turner JL, Welch MJ, Wooley KL: 64Cu-labeled folate-conjugated shell cross-
linked nanoparticles for tumor imaging and radiotherapy: synthesis, radio labeling and biological
evaluation. J Nucl. Med. 2005; 46:1210.
12. Turner JL, Pan D, Plummer R, Chen Z, Whittaker AK, Wooley KL: Synthesis of Gadolinium Labeled Shell
Crosslinked Nanoparticle for Magnetic Resonance Imaging Applications. Adv. Func. Mat. 2005; 15:1248.
13. Pan D, Turner JL, Wooley KL: Shell crosslinked nanoparticles designed to target angiogenic blood
vessels via avß3 receptor-ligand interactions. Macromolecules 2004; 37:7109.
14. Pan D, Turner JL, Wooley KL: Folic acid conjugated nanostructured materials designed for cancer cell
targeting. Chemical Communications 2003; 19:2400.
15. Pan D, Mal SK, Kar GK, Ray JK: Highly chemoselective method for the synthesis of 4-hydroxy-4-
allylcyclohexa-2,5-dienone derivatives by indium-mediated allylation protocol. Tetrahedron 2002; 58:2847-
2852.
D. RESEARCH SUPPORT
0835426N (Pan) 7/1/2008-6/30/2012 4.2
American Heart Association $70,000 calendar
A Nanomedicine Approach to Coronary Ruptured Plaque with spectral Computed Tomography
The aims of the proposal are 1) Synthesis and characterization of thrombus (fribin) specific
nanoparticles for K-edge-based Spectral CT imaging. Synthesize and physic-chemically
characterize novel bismuth based nano-colloids (BiNCs) for Spectral CT and optimize fibrin-bound
BiNCs for spectral CT contrast using in vitro clot phantoms. Determine the stability of the Spectral
CT BiNCs to sterilization, exposure to blood/plasma, and storage. 2) Evaluate and refine Spectral
CT bismuth nano-colloids (BiNCs) in vivo for detection of intravascular thrombus. Demonstrate
fibrin-specific Spectral CT agent for detection and quantification of fibrin specific BiNCs in dogs
(first in situ and then circulating). Delineate the pharmacokinetics, bio-distribution and gross
toxicological behavior of the preferred fibrin-targeted Spectral CT BiNCs in dogs.
U54 CA119342 (Wickline) 9/30/2005-8/31/2010 6
National Institutes of Health $369,333 calendar
The Siteman Center of Cancer Nanotechnology Excellence at Washington University
Project 1 - Neovascular-Directed Nanoparticles for Detection, Characterization and Treatment of
Neoplasia with MRI (Lanza)
The subject of this proposal is the application of a novel paramagnetic site-targeted contrast
"platform technology" for sensitive and specific imaging of molecular epitopes expressed on tumor
neovasculature alone and in combination with the local delivery of chemotherapeutic agents to
these sites.
091076 (Pan) 3/1/2010-2/28/2011 1.56
Missouri Life Sciences Research Board $35,000 calendar
Development and characterization of K-edge metal nanocolloids (NanoK) for detection of thrombus with
spectral computed tomography (Spectral CT)
The specific aims of this project are:
(A) Synthesize and characterize Spectral CT K-edge metal nanocolloids
(NanoK) and define their stability with sterilization and storage. (1-5 months)
For the preliminary demonstration of in vitro, ex vivo and in vivo spectral CT contrast, fibrin specific bismuth
nanocolloids were used. The K-edge x-ray absorption of bismuth is very high (~90KeV) in comparison to Au
(~80KeV) and W (~60KeV), which often becomes problematic in terms of separating Bi from photo effect.
Therefore, for this project, while we continue to explore the bismuth nanoparticles, we will emphasize on the
development of gold and tungsten based NanoKs. More specifically, we will synthesize and characterize novel
K-edge metal based nanocolloids (NanoK-Au, W). The goal would also be to chemically and physically
characterize NanoK and define the stability with sterilization and storage. The gross toxicological behavior of
NanoK will be determined in vitro.
(B) Characterize NanoK in vitro and vivo for detection of intravascular
thrombus with spectral CT and delineate in vivo preliminary clearance and toxicity profile. (5-12 months)
Anti-fibrin NanoK of varying compositions emerging as candidates from aim 1 will be studied first in vitro to
characterize their spectral and CT signals followed by their in vivo evaluation. More specifically, NanoKs will be
characterized in vivo for detection of intravascular thrombus with Spectral CT in a rabbit model and in vivo
preliminary clearance and toxicity profile will be delineated.
# not assigned (Pan) 1/1/2011-12/31/2012 2.4
American Heart Association $68,130 calendar
Photoacoustic tomography theranostic approach to diagnosis and treatment of carotid disease
This proposal will develop nanomedicine techniques and advanced noninvasive photoacoustic
imaging technologies to achieve more sensitive diagnosis of unstable/ruptured plaque to help
stratify patients into appropriate treatment regimens, and to stabilize or reverse luminal
thrombosis and plaque progression processes.
Completed Research Support
N01-CO-27103 Karen L Wooley (PI) 3/1/2002-6/30/2004
National Cancer Institute
Department of Chemistry at Washington University
Nanoscale Bioconjugates as Passive and Active Detection, Diagnosis and Treatment Systems
The subject of this proposal was the development of polymeric nanoparticle based multi-component
recognition units that will harness the information generated from the human genome project to prepare
devices that can be produced with a few building blocks by an automated process for cancer-specific mRNA
targeting and imaging, and thus, early detection and diagnosis.
Role: Researcher