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Animal Care and Use Review Form

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                                                                               Protocol #
                                                                               Date Approved
                                                                               Date Expires


                                                 The University of Iowa
                                            Animal Care and Use Review Form

University policy and federal regulations require a review of projects for humane treatment and
safe use of vertebrate animals in research and teaching by all University of Iowa staff on or off
campus. At the University of Iowa, the review is conducted by the Institutional Animal Care and
Use Committee (IACUC). The U.S. Public Health Service requires verification of IACUC
approval of animal care and use for funded projects before monies will be released for use. For
projects funded by non-PHS agencies; verification of IACUC approval of animal care and use
generally must occur within 60 days after submission of an application or proposal. Six weeks is
required to process this application. Please complete all parts of the attached form. Additional
information to clarify some questions can be accessed by clicking on the icon adjacent to the
question. This application must be completed on a word processor, and submission must include a
signed hardcopy and computer file (Word, Word Perfect or Adobe). E-mail the file to
acurf@uiowa.edu. For externally sponsored projects, please provide a hardcopy of the
Research Plan portion of the grant/contract application. Please return the signed hardcopy of
this form and the Research Plan portion of the grant/contract to the OAR, 400 Medical
Laboratories. This document is best viewed in “Print Layout”. It is recommended, that first-time
users of this form schedule an appointment with the IACUC coordinator by sending an e-mail to
acurf@uiowa.edu or calling 5-7985.

I. Principal Investigator:
Name
Department
Campus Address
Telephone #
E-mail address
Lab phone
Lab Address(Building,
Rm#)
Please copy and paste this table to add additional personnel.

Co-Investigator(s):
Name
Department
Campus Address
Telephone #:
E-mail address
Please copy and paste this table to add additional personnel.

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II. Project Information:
Project title: (Use the same title as the grant application; For Center, PPG, or Training Grant, use subproject title.)

Grant Application
Deadline
Project Start Date


III. Funding Information: Answer all Three Questions Yes or No

     Yes            No      External funding expected: (Please provide a hard copy of research plan
                            portion of grant)
     Yes            No      Research Plan attached: If not attached please explain:
     Yes            No      Internal funding expected;(If YES, Departmental review and assurance are
                            required [see VII])

Funding Agency Name
Funding Agency Number (if known)

IV. Type of project:
     Yes        No                New Project
     Yes        No                Renewal                                       Previous ACURF#
     Yes        No                Duplicate Submission                          Previous ACURF #
     Yes        No                Instructional project
     Yes        No                Part of training grant:                       Program Dir.
     Yes        No                Part of center or program                     Program Dir
                                  project;

V. SPECIAL CONCERNS
Answer ALL of the following:
Please read the material hyperlinked to any positive response:
        Yes               No
                        Instructional use of animals (teaching course or training class)
        Yes               No
                        Survival surgery
        Yes             Hazardous chemicals, Biological agents, Recombinant DNA (including
                          No
                        production of transgenic animals), other biohazardous agents
      Yes         No Death as an endpoint (i.e. LD50, tumor growth).
      Yes         No Custom antibody production by outside vendor
      Yes         No Production of monoclonal antibodies using ascites method
      Yes         No Use of Complete Freund's Adjuvant
If you answer yes to any of the above questions click on the associated link to obtain additional
information

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VI. PROJECT DESCRIPTION

1.    If this is an initial application summarize in language that a high school student can
      understand, the aims and objectives of this project including its long-term goals and briefly
      explain the relevance this work will have to human or animal health, the advancement of
      knowledge or the good of society. The grant abstract may not be used. If animals in this
      proposal will be used for instructional purposes also list the course objectives.   If the answer
      is longer than one page the contents in the box often will not all appear. To enter a longer answer click in the
      box, then go to the top menu, click on “Table” then click on “Convert” and then click on “Table to text”.




      If this is a renewal application summarize in language that a high school student can
      understand, what was learned during the initial approval and explain how the results influence
      the continuation of the project. Briefly explain the relevance this work will have to human or
      animal health, the advancement of knowledge or the good of society. The grant abstract may
      not be used. If animals in this proposal will be used for instructional purposes also list the
      course objectives.     If the answer is longer than one page the contents in the box often will not all appear.
       To enter a longer answer click in the box, then go to the top menu, click on “Table” then click on “Convert”
      and then click on “Table to text”.




QUESTIONS SPECIFICALLY MANDATED by Regulations
2. a. You must perform database searches unless compelling justification can be made without
      it. A standard literature search is the usual method to demonstrate this project is not
      “unnecessarily duplicative” and to search for “alternative experimental approaches.” To
      search for alternatives, match the basic problem under investigation (e.g, heart failure,
      hypertension, arrhythmia) to terms or phrases like “animal testing alternatives”,
      simulations, in vitro, or cell culture. If a database search was performed please answer
      ALL four of the following questions.

 Database(s) Searched:
 Date of Search (must be within two months of
 submission)
 Years Searched (range):
 Search Terms and/or Search Strategy

      b.    If a literature search is NOT performed, provide a narrative to justify why this project is
            not duplicative and that no acceptable alternatives are available.


      c.    Comment upon the potential application of any identified alternatives.


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      d.    Describe what consideration has been given to the following alternatives :
                -Reducing the numbers of animals required
                -Modifying a procedure to lessen or eliminate pain or distress to the animal
                -Use of a non-mammalian or invertebrate species
               -Use of a non-animal system (cell or tissue culture, computer model, mathematical
               model, etc.)



3.    Is this project unnecessarily duplicative?

           No Proceed to Question 4.
           Yes Proceed to Question 4.


PERSONNEL:
4. Personnel: Please provide the following information for all personnel involved in this project
   who will handle animals, including investigators, technicians and students. Describe the
   relevant training and experience of each person. If personnel do not have experience, describe
   how they will be trained. Participation in the University Employee Health Clinic ((UEHC)
   Clinic A; Boyd Tower; 356-3632) program for animal users is determined on a case by case
   basis for all persons having any contact with animals or animal tissues. List all individuals
   having contact with animals, the species involved and a brief description of the degree of
   contact (e.g. rodents, less than 2 hours/week). Include their University address, phone
   number, e-mail address, so that they can be contacted by the UEHC regarding enrollment in
   the program.
      Principal Investigator/Coinvestigators: Please complete for each investigator listed in I. (first page)
        Name:
        Describe Training:
        Has this person taken the University                        Yes
        online training module on
        Policies/Regulations?                                      No
        Describe related experience with
        techniques Proposed:
        Describe how individual will be
        trained if no prior relevant
        training or experience
        Is this person performing                                   Survival Surgery
        surgery?
                                                                    Nonsurvival surgery
                                                                    Not Applicable

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        Describe exposure to each
        species that will occur during
        performance of this proposal.
      Please copy and paste this table to add additional investigators


      Technical Personnel
        Name:
        Address:
        Dept:
        Phone #:
        E-mail address:
        Describe Training:
        Has this person taken the University                      Yes
        online training module on
        Policies/Regulations?                                     No

        Describe related experience with
        techniques Proposed:
        Describe how individual will be
        trained if no prior relevant
        training or experience
        Is this person performing                                 Survival Surgery
        surgery?
                                                                  Nonsurvival surgery
                                                                  Not Applicable
        Describe exposure to each
        species that will occur during
        performance of this proposal.
      Please copy and paste this table to add additional personnel.
      NOTE: All personnel are required to take the Online course for “Policies/Regulations”
      and pass the associated quiz. (http://courses2.uiowa.edu:8900/public/AUEC/index.html)


ANIMAL Information
5.
    Animal species (common name)

        Strain (if applicable)


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       Describe the biological
       characteristics of each species
       that are essential to the proposed
       study
      Please copy and paste this table to add additional species/strains.
      Guidelines for proper nomenclature:

6.    a.    Approximately how many of each species will be used? You must include the total
            number of each species to be used over the three year duration of this proposal. This
            approval is for a maximum of three years. Do not count rodents that are not weaned.
            [NOTE: U.S. Government Principles for the Utilization and Care of Vertebrate Animals
            used in Testing, Research, and Training: III. The animals selected for a procedure should
            be of an appropriate species and quality and the minimum number required to obtain
            valid results.
        Species/
        Strain
        Total

      Please copy and paste this table to add additional species/strains.

b.    Describe how the number of animals needed for the study was determined. When appropriate,
      provide the number and type of experimental and control groups in each experiment, the
      number of experiments planned, and the number of animals in each group. The Guide states
      that whenever possible, the number of animals requested should be justified statistically. A
      power analysis is strongly encouraged to justify group sizes when appropriate.      If the answer
      is longer than one page the contents in the box often will not all appear, to solve this problem click in the box
      then go to the top menu, click on “Table” then click on “Convert” and then click on “Table to text”.



c.    What is the source of the animals?
             Yes           No Via the OAR
             Yes           No Breeding colony in house

d.    Are Transgenic Animals utilized in this study?
            No Proceed to Question 7.
            Yes

e.    Does expression of the transgene/knockout phenotype result in pain/distress?
            No Proceed to Question 7.
            Yes It is mandatory that you answer Question 23 even if you answer Yes to
                  Question 18 or 20.


7.    Will the animals used in this study be subjected to any of the following                       :


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              Yes             NoThe animal(s) utilized in this study will have already been used in a
                                previous study (non-naïve animals)?
            Yes         No The same animal(s) used in this study may be used in a future?
      If yes to either of the above, please explain.

      Note: Prior Committee approval is required for each of the above.

8.    Animal Housing Location:
          Yes      No University of Iowa Animal Care Unit
          Yes      No Veterans Administration Research Facility
          Yes      No Other: Please
                        describe

9.    Will animals be kept outside of the OAR animal quarters for longer than 12 or 24 hours
           No; Proceed to next question
           > 12 hours      Building and Room #
           > 24 hours      Building and Room #

      If housed outside of OAR for > 24 hours please justify this requirement:


10. Will any special housing conditions be required for this project (lighting, feed, special caging,
    biological containment, etc.)?
         No; Proceed to Next Question
         Yes Please Specify




11. Do you request that rodents be housed in wire bottom cages?
        No or Not Applicable; Proceed to Next Question
        Yes; Please Justify



12. Do you request that nonhuman primates be excluded from the University of Iowa’s
      “Psychological Enrichment Program”? This program is designed to provide an enriched
      environment including social interactions among primates in use at the University.
        No or Not Applicable; Proceed to Next Question
        Yes; Please Justify




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13. Do you request that dogs be excluded from the University of Iowa’s “Canine exercise
      Program”?
         No or Not Applicable; Proceed to Next Question
         Yes; Please Justify



HAZARD USE

14. Does this study utilize rDNA in vivo AND the animals are returned to the Animal Care Unit
      after exposure?
          No or Not Applicable; Proceed to Next Question
          Yes; Specify rDNA

      If yes, please complete and submit rDNA application to the Health Protection Office, available
      online or contact the Health Protection Office (HPO) at 335-8501. If an approval has
      already been received, please note approval:
        rDNA approval number


      NOTE: If rDNA is used AT ALL (whether in animals or not) it’s use must be approved by the
      Institutional Biosafety Committee (IBC). Approval of this Animal Care and Use form does not
      approve the use of rDNA. rDNA use can only be approved by the IBC which is coordinated
      through the Health Protection Office (335-8501).


15. Are any of the substances listed in 15.a. used in this project?
          No or Not Applicable; Proceed to Question 16.
          Yes; Please complete 15a. & 15.b.


      a.
       Substance                                                                     Specify Substance
       Human blood, blood products, tissues
       Animal cells or extracts (from sources outside the
       OAR barrier facility)
       Non-sterile biological fluids
       Other Biological agents (other than rDNA, e.g.
       infectious agents)
       Carcinogens
       Hazardous chemicals
       Radioactive materials



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      b.    Are any of the substances listed in 15.a. introduced into animals that are returned to the
            Animal Care Unit ALIVE:
             No or Not Applicable; Proceed to Question 15.e.
             Yes; Please complete 15.c.


      c.    Please complete and attach a containment protocol to this ACURF. Prior to initiation
            of this protocol, inform the OAR when use of the hazardous agent/material is pending to
            ensure the protection of OAR personnel. Forms are available at :

            Have you appended a containment protocol?
             Yes; Proceed to Question 15.e.
             NO; Please complete 15.d.

      d.    If a containment protocol is NOT necessary please provide your rationale:


      e.    Could any of the hazardous substances listed in 15.c.contaminate Animal Caging?
             No; Proceed to Question 16.
             Yes; Please complete 15.f.


      f.    If NOT already described in a submitted containment protocol (15.c.) please describe how
            you will decontaminate caging or equipment before returning it to the Animal Care Unit.




EXPERIMENTATION

16. Describe fully the method of euthanasia that will be employed for each species                   .
    a. Method

     Species
     Chemical Agent
         Not applicable:
         Dose
         Route
     Physical Method
         Not applicable:
Please copy and paste this table to add additional methods/species.


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      b.   Scientific justification must be provided to perform euthanasia by a Physical method in an
           UNanesthetized or UNsedated animal.
           Not applicable (Proceed to Question 17.
        Scientific justification

17. Are tissues collected before euthanasia? If tail samples are taken for genetic analysis please
         indicate here and review IACUC guidelines
          No; Proceed to Question 18.
          Yes; Please list tissues harvested

18. Is the “only” procedure: euthanasia performed followed by harvest of tissues?
          No; Proceed to Question 19.
          Yes; You are finished; you do not need to complete the rest of the form

19. Will any procedures (surgical or non-surgical) require anesthesia?
    Anesthetic dosages can be found at this link
         No; Proceed to Question 20.
         Yes

      a. Preanesthetic agent(s), dosage and route
       Species
       Drug (e.g. Atropine)
       Dosage (mg/kg)
       Route (IV, IM, SQ, IP)
           Please copy and paste additional tables if needed.
      b. Anesthetic agent(s), dosage and route
       Species
       Drug (e.g. Pentobarbital)
       Dosage (mg/kg)
       Route (IV, IM, SQ, IP)
      Please copy and paste additional tables if needed.

      c.    For prolonged procedures how will anesthesia be maintained?


      d.    How many times will anesthesia be required for each animal during the study              ?


      e.    Describe the methods used to monitor the state of anesthesia and general well being          :


      f.    Will paralytic agents be employed?
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             No; Proceed to 19.g.
             Yes; Name of agent
        Explain why it is necessary to use
        this agent
        Explain how the animals will be
        monitored to insure adequate
        anesthesia

      g. Is the proposed postprocedural and postanesthesia monitoring in accordance with IACUC
         recommendations?
           Yes; Proceed to 20.
           No; Specify the procedures that will be utilized below


20. Is the “only” procedure performed the harvest of tissue and/or body fluids under anesthesia
          followed by euthanasia?
            No; Proceed to Question 21.
            Yes; You are finished; you do not need to complete the rest of the form

21. Will antemortem blood samples be taken?
           No; Proceed to Question 22.
           Yes
     Species
     Route
     Amount
     # of collections
     Interval between
     collections
     Will blood collection be performed under anesthesia?
           Yes; Anesthesia should be described in answer to Question 19.
           No
    Please copy and paste additional tables if needed.

22. Is any procedure (including survival surgery) likely to cause pain or distress (e.g. any
    procedures that would reasonably be expected to cause pain or distress in a human)? Common
    analgesic dosages can be found at this link
    Do not provide anesthetic regimens; these are already described in Question 19.
           No; Proceed to Question 23.
           Yes
     Species
     Identify Painful
     Procedure
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       Methods to alleviate
       pain/distress
       Justification for not
       providing relief from
       pain/distress
      Please copy and paste additional tables if needed.

23. Are there predictable adverse pre- or post-procedural events that may occur?
          No; Proceed to Question 24.
          Yes; Please describe event below and indicate how it will be humanely managed to
          minimize discomfort to the animal

      Please copy and paste additional tables if needed.

24. Will food and/or water be restricted?
          No; Proceed to Question 25.
          Yes       What is restricted?      Food                                   Water
     Species
     Length of restriction
     Interval between restrictions
     Monitoring during restriction
     Justify restricting food and/or water
    Please copy and paste additional tables if needed.

25. Will animals be restrained by tethers, stanchions, metabolism cages, etc.?
          No; Proceed to Question 26.
          Yes          Species
     Method of restraint
     Duration of restraint
     Frequency of restraint
     Monitoring during restraint
     Acclimation of animal to
     restraint
     Justify restraint
    Please copy and paste additional tables if needed.

26. Will survival surgical procedures be employed? (Disruption of any integumentary surface of
    a living animal by any means other than a hypodermic needle, biopsy needle, ear punch, or tail
    snip is considered surgery. All surgical procedures must be described in Question 27.)
      NOTE: If survival surgery is performed it must be done using aseptic technique. Provide a
      description of the surgery in your answer to Question 27; describe the anesthetic regimen in
      your answer to Question 19 and describe your analgesic regimen in your answer to Question
      22.
            No; Proceed to Question 27
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               Yes; Proceed to 26.a.

      a. Will “multiple” survival surgeries be performed on the same animal?
            No; Proceed to Question 26.b.
            Yes; You must provide a detailed scientific justification as required by Federal
            regulations


      b. Where will the survival surgery be performed?
      Bldg:                               Room:

      c.  Describe the postoperative care, fluids, physical support methods and postoperative
          monitoring given to the animals.
      Species                      Monitoring
                                   provided
      Please copy and paste additional tables if needed.

      d.         Is the proposed postprocedural and postanesthesia monitoring in accordance with
                 IACUC recommendations?
               Yes;
               No; Specify below the procedures that will be utilized

      Please copy and paste additional tables if needed.

      e.     How are the instruments sterilized?
              Steam Sterilization
              Ethylene oxide
              Chemical                Please answer next the question in the table and review
              sterilization           IACUC guidelines
              Name of sterilant

      f.    How do you insure that proper sterilization has occurred (check all that apply)
             All sterilization is performed by University Hospitals Central Sterilizing
             Integrator strips on inside of steam/ethylene oxide sterilized pack
             Indicator on outside of steam/ethylene oxide sterilized pack


      g.    Does the surgeon utilize the following during surgery?
             Yes       No       Sterile gloves
             If NO Why Not?
             Yes       No       Sterile gown
             If NO Why Not? Not required for rodent/ectotherm surgery
                                Other reasons

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              Yes     No                  Face mask
              If NO Why Not?


27. For each distinct procedure, describe the manipulations that will be performed (including
    surgery) and the order in which they will be performed. Include time frames and intervals for
    the sequence of procedures. Unless listed elsewhere in this document, describe all drugs
    (including test substances) administered during the study as well as the dosage, route, and
    frequency. Procedures that will be performed after the animal has been euthanized need not
    be described. (Describe the procedures in enough detail so that reviewers will be able to
    determine what is actually being done to the animal. You DO NOT need to re-describe in
    detail procedures addressed in previous Questions (e.g anesthesia, euthanasia)     If the answer
      is longer than one page the contents in the box often will not all appear. To enter a longer answer click in the
      box, then go to the top menu, click on “Table” then click on “Convert” and then click on “Table to text”.




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II. Assurances and Approvals



(Signature of Departmental Executive Officer)                                                        (Date)
(“Per signature not acceptable)

If this project will not receive external peer review prior to beginning work with animals, the
DEO must designate an individual or committee for scientific review and assurance of this
ACURF. This person/committee member cannot be involved in this project.


(Signature Certifying Scientific Review and Approval)                                                (Date)


The policies and procedures of the University of Iowa, the AWA and the PHS apply to all activities
involving live vertebrate animals performed at or by the personnel of this Institution. Therefore, no
activities involving the use of these animals are to be initiated without prior written approval by the
University Animal Care and Use Committee (IACUC).

The undersigned is familiar with the AWA and the PHS Policy on Humane Care and Use of
Laboratory Animals by Awardee Institutions, the NIH Guide for the Care and Use of Laboratory
Animals and the University Guidelines, and agrees to abide by the Principles for the Utilization
and Care of Vertebrate Animals Used in Testing, Research, and Training contained in this
document. I assure that I will obtain IACUC approval prior to significant changes in the protocol. I
assure that students, staff, and faculty on the project are qualified or will be trained to conduct the
project in a humane and scientific manner. Any change in the care and use of animals involved in
this protocol that would affect their welfare will be promptly forwarded to the IACUC for review.
Such changes will not be implemented until the Committee's approval is obtained. Animals will
not be transferred between investigators without prior approval.




(Signature of Principal Investigator)                                                                (Date)
 ("Per" Signature not acceptable)




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Approvals


   Refer to IACUC
Signature                                                                                   Date:



    Administrative Approval
         Duplicate Submission
         Approved by Full IACUC at                           Date:
         convened meeting
      Signature                                                                             Date:



   Veterinary Review Complete                                                                  Refer to IACUC
Signature of Veterinarian                                                                   Date:



   Approved                                                                                    Refer to IACUC
Signature of Designated Reviewer                                                            Date:




                                                  Comments of University Reviewers:




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                                      INFORMATION AND INSTRUCTIONS FOR THE
                                     ANIMAL CARE AND USE REVIEW FORM (ACURF)

Please complete all parts of the attached form. This application must be completed on a word processor, and
submission must include a signed hardcopy and computer file (Word or Word Perfect format). E-mail the
file to acurf@uiowa.edu. Please return the signed hardcopy to the OAR, 400 Medical Laboratories. The
reviewers would also appreciate the formatting of your answers in a manner that allows for ease of review
(i.e. boldface). Please note: Six weeks is required to process each application.

University policy and federal law require a review of projects for humane treatment and safe use of
vertebrate animals. At the University of Iowa, the review is conducted by the University Institutional
Animal Care and Use Committee (IACUC).

Principal investigators and course directors must obtain approval from the IACUC before initiating any
research, testing or instructional project involving the use of live vertebrate animals. (The U.S. Public
Health Service requires verification of IACUC approval of animal care and use for funded projects before
monies will be released for use. For projects funded by non-PHS agencies; verification of IACUC approval
of animal care and use generally must occur within 60 days after submission of an application or proposal.
Projects with multiple components, such as Program Projects, may require several ACURFs. IACUC
approval must also be obtained prior to significant changes in previously approved protocols.

The maximum period of approval is three years. (An annual review of your approved protocol is also
required utilizing the Annual Review Form, which will be sent to you 60 days prior to the annual date.)
Prior to initial IACUC review, an approval number will be assigned to the project. No project involving the
use of vertebrate animals may be initiated without approval by the IACUC, including projects where animals
are not directly purchased (e.g. wild trapping, in-house breeding, field observation).

The Office of Animal Resources (OAR) may be contacted for guidance in selecting analgesics, anesthetics, methods for
euthanasia, nursing care techniques, etc. The OAR maintains a repository of information on veterinary medicine, laws and
standards, and many aspects of the humane care and use of animals. OAR professional and technical staff are available for
training and instruction of groups or individuals in animal manipulations. Instructional Material is available on the OAR Home
Page:
http://research.uiowa.edu/animal
Please note that approved and funded (or activated) ACURFs are available for public inspection (Iowa
Public Records Act, Chapter 22, Iowa Code). In order to ensure that the information contained in this form
is not misinterpreted, it is imperative that significance, aims and procedures of your protocol be in terms
which are understandable by the lay public. Your attention to this will greatly facilitate the dissemination of
accurate information concerning the essential role of animals in research and teaching. Be assured also that
you will be contacted before any information concerning your project is released. It is also advised and
encouraged that information supplied to the public and to the news media be made available with the
assistance of the Health Science Relations Office 335-8037 or University Relations Office 335-0557.

If you have concerns regarding the security of the animals or the animal facilities, contact OAR at 335-7985
or Department of Public Safety at 335-5027.



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      UNIVERSITY OF IOWA PRINCIPLES
      FOR THE CARE AND USE OF LABORATORY ANIMALS

(Adapted from the U.S. Government Principles for the Utilization and Care of Vertebrate Animals Used in
Testing, Research, and Training)

I. The transportation, care and use of animals must be in accordance with the Animal Welfare Act and
other applicable federal and state laws, guidelines, and policies.

II. Procedures involving animals should be designed and performed with due consideration of their
relevance to human or animal health, the advancement of knowledge, or the good of society.

III. The animals selected for a procedure should be of an appropriate species and quality and the minimum
number required to obtain valid results. Alternative methods such as mathematical models, computer
simulation, and in vitro biological systems must be considered.

IV. Proper use of animals, including the avoidance or minimization of discomfort, distress, and pain when consistent with sound
scientific practices, is imperative. Unless the contrary is established, investigators must consider that procedures that cause pain or
distress in human beings may cause pain or distress in other animals.

V. Procedures with animals that may cause more than momentary or slight pain or distress should be
performed with appropriate sedation, analgesia, or anesthesia. Surgical or other painful procedures must not
be performed on unanesthetized animals paralyzed by chemical agents.

VI. Animals that would otherwise suffer severe or chronic pain or distress that cannot be relieved must be
painlessly euthanized at the end of the procedure or, if appropriate, during the procedure. UI veterinarians
have the authority to euthanize animals whose welfare is seriously threatened. The action will follow
contact or several efforts to contact the responsible investigators.

VII. The living conditions of the animals should be appropriate for their species and contribute to their
health and comfort. Normally the housing, feeding, and care of all animals used for biomedical purposes
must be directed by a veterinarian or other scientist trained and experienced in the proper care, handling, and
use of the species being maintained or studied. In any case, veterinary care shall be provided.

VIII. Investigators and other personnel shall be appropriately qualified and experienced for conducting
procedures on living animals. Adequate arrangements shall be made for their in-service training, including
the proper and humane care and use of laboratory animals.

IX. Where exceptions are required in relation to the provisions of these Principles, the decisions should not
rest with the investigators directly concerned but should be made, with due regard to Principle II, by an
appropriate group such as an institutional animal research committee. Such exception should not be made
solely for the purpose of teaching or demonstration.




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(Revised 1 6/11/03) Please download the latest form at http://research.uiowa.edu/animal/?get=forms

				
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