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PHARMACOKINETICS, PIGS Tylosin Tylvalosin Tilmicosin Tulathromycin
INTRAVENOUS
distribution volume, l/kg
elimination half-life, hours
Reference
INTRAMUSCULAR
elimination half-life, hours 0.20
absorption half-life, hours 1.55
absorptionkoefficient, F/V 1.50
Reference
INTRAMUSCULAR, PROLONGATUM
elimination half-life, hours 52.98
absorption half-life, hours 4.70
absorptionkoefficient, F/V 0.06
Reference Benchaoui et al. (2004)
ORAL
elimination half-life, hours 1.89 NO DATA 3.85
absorption half-life, hours 1.88 NO DATA 1.73
absorptionkoefficient, F/V 0.06 NO DATA 0.15
biotilgængelighed, %
Reference Laber Shen 2005
Lincomycin Tiamulin Valemulin
NO DATA 7.26
NO DATA 0.85
NO DATA 0.08
#1590
Benchaoui et al. (2004)
2.75 3.51 NO DATA
2.70 1.17 NO DATA
0.37 0.11 NO DATA
40.00 90.00
#1334
Tissue or secret/plasma ratio
Tylosin Tylvalosin
Lungs total tissue 4-5
bronchial epithelium
bronchial secret
Nose nose epithelium
nose secret
Milk normal, pH: 6.6 3.0
acute mastitis, pH: 7.2
Uterus total tissue
endometrium
uterus secret
Intestine total tissue
intestine epithelium
intestine secret
Peritonium peritoneal fluid
Joints synovial fluid
Brain meninges
Exp. implan. fluid
References 3440, 4300
Tilmicosin Tulathromycin Lincomycin Tiamulin Valnemulin
6 51 25
8
2.8
0.6
0.5
Keles et al 2001 ? 250, 4930
Reference: Sauter RA et al. 1962
Tylosin, IM TYPE IN
32.00
MIC, µg/ml 0.10 0
postantibiotic time, hours 2.40 10.0
dosing interval, hours 12.00
tissue/plasma ratio 5.00
weight of animal, kg 50.00
number of animals 1.00
treatment period, 24 hours 3.00 1.0
Conc. (mcg/ml)
drug concentration, mg/ml or mg/g 100.00
product price, kr./ml or g 0.00
RESULTS
initial dose, [mg/kg] [ml or g/animal] 11.41 5.70 0.1
maintenance dose, [mg/kg] [ml;g/animal] 11.13 5.56
drugs in all, ml or g 33.53
expenses, kr. 0.00
0.0
CONCENTRATIONS
maximum plasma concentration, mg/l 0.08
minimum plasma concentration, mg/l 0.06
maximum tissue concentration, mg/l 0.40
minimum tissue concentration, mg/l 0.31
drugs ml or g per animal 33.53
recommended dose, mg/kg 10.00
withdrawal time slaughter, 24 hours 30.00
prolongation of withdrawal time from plasma, hours 0.36
t1/2el, hours 1.89
t1/2ab, hours 1.88
F/V 0.06
F, %
1 1 2 2 3 3
Plasma
Tissue
MIC
Plasmai
Tissuei
Days
Time n Hours
Cmic 0.02
ka 0.37 1 1 1
ke 0.37 2 1 2
4 1 4
aT 0.01 6 1 6
eT 0.01 12 1 12
tmax 5.84 1 2 13
etmax 0.12 2 2 14
Cmin 0.01 4 2 16
Dv 2.50 6 2 18
Cmax 0.02 12 2 24
Dp 2.56 1 3 25
cmaxcmic 0.90 2 3 26
DpFakt 11.41 4 3 28
DvFakt 11.13 6 3 30
CmaxFakt 0.08 12 3 36
CminFakt 0.06 1 4 37
faktor,MIC 4.00 2 4 38
4 4 40
6 4 42
Dpkorrekt 11.41 12 4 48
1 5 49
Dvkorrekt 11.13 2 5 50
4 5 52
Cmaxkorrekt 0.08 6 5 54
Cminkorrekt 0.06 12 5 60
medicin dyr 33.53
medicin i alt 33.53
pris 0.00
Time Stomac Duodenum Jejunum_1 Jejunum_2 Ileum
days ug/g
0.25 756.868 21.368 143.256 358.77 75.842
0.5 11.56 8.62 12.41 157.06 28.91
1 2.561 5.533 2.772 5.729 4.514
1.5 0.2473 1.1572 0.9329 1.3344 2.7235
2 2.3668 3.0654 3.0109 4.6475 2.4363
3 0.182 1.0628 1.0638 1.411 1.7622
4 0.4717 0.7534 0.91777 1.73876 1.7004
6 0.06122 0.39987 0.54112 0.4793 0.58301
Zn dosis, ppm 2500
Foder/gang, kg 0.35
vægt, kg 10
Zn dosis, mg/kg 875
Oxytertracyclin Jejunum
Dosis mg/kg 11.13 4.56334
1.99771
0.07287
0.01697
0.05911
0.01795
0.02212
0.0061
kaFVD/ka-ke enkeT enketi ekeT enkaT ekati ekaT Plasma Tissue
84.64 0.01 0.69 0.01 0.01 0.69 0.01 0.17 0.86
84.64 0.01 0.48 0.01 0.01 0.48 0.01 0.24 1.18
84.64 0.01 0.23 0.01 0.01 0.23 0.01 0.23 1.14
84.64 0.01 0.11 0.01 0.01 0.11 0.01 0.16 0.82
84.64 0.01 0.01 0.01 0.01 0.01 0.01 0.04 0.18
84.64 0.00 0.69 0.01 0.00 0.69 0.01 0.20 0.99
84.64 0.00 0.48 0.01 0.00 0.48 0.01 0.26 1.29
84.64 0.00 0.23 0.01 0.00 0.23 0.01 0.24 1.19
84.64 0.00 0.11 0.01 0.00 0.11 0.01 0.17 0.85
84.64 0.00 0.01 0.01 0.00 0.01 0.01 0.04 0.19
84.64 0.00 0.69 0.01 0.00 0.69 0.01 0.20 0.99
84.64 0.00 0.48 0.01 0.00 0.48 0.01 0.26 1.29
84.64 0.00 0.23 0.01 0.00 0.23 0.01 0.24 1.19
84.64 0.00 0.11 0.01 0.00 0.11 0.01 0.17 0.85
84.64 0.00 0.01 0.01 0.00 0.01 0.01 0.04 0.19
84.64 0.00 0.69 0.01 0.00 0.69 0.01 0.20 0.99
84.64 0.00 0.48 0.01 0.00 0.48 0.01 0.26 1.29
84.64 0.00 0.23 0.01 0.00 0.23 0.01 0.24 1.19
84.64 0.00 0.11 0.01 0.00 0.11 0.01 0.17 0.85
84.64 0.00 0.01 0.01 0.00 0.01 0.01 0.04 0.19
84.64 0.00 0.69 0.01 0.00 0.69 0.01 0.20 0.99
84.64 0.00 0.48 0.01 0.00 0.48 0.01 0.26 1.29
84.64 0.00 0.23 0.01 0.00 0.23 0.01 0.24 1.19
84.64 0.00 0.11 0.01 0.00 0.11 0.01 0.17 0.85
84.64 0.00 0.01 0.01 0.00 0.01 0.01 0.04 0.19
Colon Caecum
171.044 604.646
1135.32
436.503 78.708
43.8104 9.7317
87.8152 19.9664
2.9722 1.8359
2.8816 1.83835
0.47058 0.26127
Colon Days MIC
2.17557639 0.25 32.00
14.4405848 0.5 32.00
5.55205457 1 32.00
0.55724183 1.5 32.00
1.11695632 2 32.00
0.03780459 3 32.00
0.03665221 4 32.00
0.00598549 6 32.00
MIC Days Plasmai Tissuei
0.10 0.04 0.18 0.88
0.10 0.08 0.24 1.21
0.10 0.17 0.23 1.17
0.10 0.25 0.17 0.84
0.10 0.50 0.04 0.19
0.10 0.54
0.10 0.58
0.10 0.67
0.10 0.75
0.10 1.00
0.10 1.04
0.10 1.08
0.10 1.17
0.10 1.25
0.10 1.50
0.10 1.54
0.10 1.58
0.10 1.67
0.10 1.75
0.10 2.00
0.10 2.04
0.10 2.08
0.10 2.17
0.10 2.25
0.10 2.50
Reference: Laber G and Schütze E, 1981
Tylosin, PO TYPE IN
MIC extracellular, relevant for Lawsonia 16.00
MIC, µg/ml 0.02 0
postantibiotic time, hours 2.40 1.0
dosing interval, hours 12.00
tissue/plasma ratio 1.00
weight of animal, kg 50.00
number of animals 1.00
treatment period, 24 hours 3.00
Conc. (mcg/ml)
drug concentration, mg/ml or mg/g 100.00
product price, kr./ml or g 0.00 0.1
RESULTS
initial dose, [mg/kg] [ml or g/animal] 5.79 2.89
maintenance dose, [mg/kg] [ml;g/animal] 5.66 2.83
drugs in all, ml or g 17.05
expenses, kr. 0.00
0.0
CONCENTRATIONS
maximum plasma concentration, mg/l 0.08
minimum plasma concentration, mg/l 0.02
maximum tissue concentration, mg/l 0.08 0
minimum tissue concentration, mg/l 0.02 100.0
drugs ml or g per animal 17.05
recommended dose, mg/kg 10.00
10.0
withdrawal time slaughter, 24 hours 1.00
prolongation of withdrawal time from plasma, hours -1.49
1.0
Conc. (mcg/ml)
t1/2el, hours 1.89
t1/2ab, hours 1.80
F/V 0.06 0.1
F, %
0.0
0.0
1 1 2 2 3 3
Plasma
Tissue
MIC
Plasmai
Tissuei
Days
1 2 3 4 5 6 7
Jenunum
Colon
MIC
Days
Time n Hours
Cmic 0.02
ka 0.39 1 1 1
ke 0.37 2 1 2
4 1 4
aT 0.01 6 1 6
eT 0.01 12 1 12
tmax 4.00 1 2 13
etmax 0.23 2 2 14
Cmin 0.01 4 2 16
Dv 2.64 6 2 18
Cmax 0.04 12 2 24
Dp 2.70 1 3 25
cmaxcmic 1.86 2 3 26
DpFakt 5.79 4 3 28
DvFakt 5.66 6 3 30
CmaxFakt 0.08 12 3 36
CminFakt 0.02 1 4 37
faktor,MIC 4.00 2 4 38
4 4 40
6 4 42
Dpkorrekt 5.79 12 4 48
1 5 49
Dvkorrekt 5.66 2 5 50
4 5 52
Cmaxkorrekt 0.08 6 5 54
Cminkorrekt 0.02 12 5 60
medicin dyr 17.05
medicin i alt 17.05
pris 0.00
Time Stomac Duodenum Jejunum_1 Jejunum_2 Ileum
days ug/g
0.25 756.868 21.368 143.256 358.77 75.842
0.5 11.56 8.62 12.41 157.06 28.91
1 2.561 5.533 2.772 5.729 4.514
1.5 0.2473 1.1572 0.9329 1.3344 2.7235
2 2.3668 3.0654 3.0109 4.6475 2.4363
3 0.182 1.0628 1.0638 1.411 1.7622
4 0.4717 0.7534 0.91777 1.73876 1.7004
6 0.06122 0.39987 0.54112 0.4793 0.58301
Zn dosis, ppm 2500
Foder/gang, kg 0.35
vægt, kg 10
Zn dosis, mg/kg 875
Tylosin Jejunum
Dosis mg/kg 5.66 2.32138
1.01624
0.03707
0.00863
0.03007
0.00913
0.01125
0.0031
kaFVD/ka-ke enkeT enketi ekeT enkaT ekati ekaT Plasma Tissue
6.80 0.01 0.69 0.01 0.01 0.68 0.01 0.09 0.09
6.80 0.01 0.48 0.01 0.01 0.46 0.01 0.12 0.12
6.80 0.01 0.23 0.01 0.01 0.21 0.01 0.12 0.12
6.80 0.01 0.11 0.01 0.01 0.10 0.01 0.08 0.08
6.80 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.02
6.80 0.00 0.69 0.01 0.00 0.68 0.01 0.10 0.10
6.80 0.00 0.48 0.01 0.00 0.46 0.01 0.13 0.13
6.80 0.00 0.23 0.01 0.00 0.21 0.01 0.12 0.12
6.80 0.00 0.11 0.01 0.00 0.10 0.01 0.09 0.09
6.80 0.00 0.01 0.01 0.00 0.01 0.01 0.02 0.02
6.80 0.00 0.69 0.01 0.00 0.68 0.01 0.10 0.10
6.80 0.00 0.48 0.01 0.00 0.46 0.01 0.13 0.13
6.80 0.00 0.23 0.01 0.00 0.21 0.01 0.12 0.12
6.80 0.00 0.11 0.01 0.00 0.10 0.01 0.09 0.09
6.80 0.00 0.01 0.01 0.00 0.01 0.01 0.02 0.02
6.80 0.00 0.69 0.01 0.00 0.68 0.01 0.10 0.10
6.80 0.00 0.48 0.01 0.00 0.46 0.01 0.13 0.13
6.80 0.00 0.23 0.01 0.00 0.21 0.01 0.12 0.12
6.80 0.00 0.11 0.01 0.00 0.10 0.01 0.09 0.09
6.80 0.00 0.01 0.01 0.00 0.01 0.01 0.02 0.02
6.80 0.00 0.69 0.01 0.00 0.68 0.01 0.10 0.10
6.80 0.00 0.48 0.01 0.00 0.46 0.01 0.13 0.13
6.80 0.00 0.23 0.01 0.00 0.21 0.01 0.12 0.12
6.80 0.00 0.11 0.01 0.00 0.10 0.01 0.09 0.09
6.80 0.00 0.01 0.01 0.00 0.01 0.01 0.02 0.02
Colon Caecum
171.044 604.646
1135.32
436.503 78.708
43.8104 9.7317
87.8152 19.9664
2.9722 1.8359
2.8816 1.83835
0.47058 0.26127
Colon Days MIC
1.1067183 0.25 16.00
7.34594271 0.5 16.00
2.82433678 1 16.00
0.28346958 1.5 16.00
0.56819701 2 16.00
0.01923124 3 16.00
0.01864502 4 16.00
0.00304483 6 16.00
MIC Days Plasmai Tissuei
0.02 0.04 0.09 0.09
0.02 0.08 0.13 0.13
0.02 0.17 0.12 0.12
0.02 0.25 0.08 0.08
0.02 0.50 0.02 0.02
0.02 0.54
0.02 0.58
0.02 0.67
0.02 0.75
0.02 1.00
0.02 1.04
0.02 1.08
0.02 1.17
0.02 1.25
0.02 1.50
0.02 1.54
0.02 1.58
0.02 1.67
0.02 1.75
0.02 2.00
0.02 2.04
0.02 2.08
0.02 2.17
0.02 2.25
0.02 2.50
NO DATA PHARMAKOKINETIC DATA AVAILABLE
Tylvalosin, PO TYPE IN
MIC extracellular, relevant for Lawsonia
MIC, µg/ml 0
postantibiotic time, hours 2.40 10.0
dosing interval, hours 12.00
tissue/plasma ratio 0.80
weight of animal, kg 50.00
number of animals 1.00
treatment period, 24 hours 3.00
Conc. (mcg/ml)
drug concentration, mg/ml or mg/g 100.00
product price, kr./ml or g 0.00
RESULTS
initial dose, [mg/kg] [ml or g/animal] #VALUE! #VALUE!
maintenance dose, [mg/kg] [ml;g/animal] #VALUE! #VALUE!
drugs in all, ml or g #VALUE!
expenses, kr. #VALUE!
1.0
CONCENTRATIONS
maximum plasma concentration, mg/l #VALUE!
minimum plasma concentration, mg/l #VALUE!
maximum tissue concentration, mg/l #VALUE! 0
minimum tissue concentration, mg/l #VALUE! 10.0
drugs ml or g per animal #VALUE!
recommended dose, mg/kg
withdrawal time slaughter, 24 hours
prolongation of withdrawal time from plasma, hours #VALUE!
Conc. (mcg/ml)
t1/2el, hours NO DATA
t1/2ab, hours NO DATA
F/V NO DATA
F, %
V, L/kg
1.0
a) relevant for Lawsonia
1 1 2 2 3 3
Plasma
Tissue
MIC
Plasmai
Tissuei
Days
1 2 3 4 5 6 7
Jenunum
Colon
MIC
Days
Time n Hours
Cmic 0.00
ka #VALUE! 1 1 1
ke #VALUE! 2 1 2
4 1 4
aT #VALUE! 6 1 6
eT #VALUE! 12 1 12
tmax #VALUE! 1 2 13
etmax #VALUE! 2 2 14
Cmin #VALUE! 4 2 16
Dv #VALUE! 6 2 18
Cmax #VALUE! 12 2 24
Dp #VALUE! 1 3 25
cmaxcmic #VALUE! 2 3 26
DpFakt #VALUE! 4 3 28
DvFakt #VALUE! 6 3 30
CmaxFakt #VALUE! 12 3 36
CminFakt #VALUE! 1 4 37
faktor,MIC 4.00 2 4 38
4 4 40
6 4 42
Dpkorrekt #VALUE! 12 4 48
1 5 49
Dvkorrekt #VALUE! 2 5 50
4 5 52
Cmaxkorrekt #VALUE! 6 5 54
Cminkorrekt #VALUE! 12 5 60
medicin dyr #VALUE!
medicin i alt #VALUE!
pris #VALUE!
Time Stomac Duodenum Jejunum_1 Jejunum_2 Ileum
days ug/g
0.25 756.868 21.368 143.256 358.77 75.842
0.5 11.56 8.62 12.41 157.06 28.91
1 2.561 5.533 2.772 5.729 4.514
1.5 0.2473 1.1572 0.9329 1.3344 2.7235
2 2.3668 3.0654 3.0109 4.6475 2.4363
3 0.182 1.0628 1.0638 1.411 1.7622
4 0.4717 0.7534 0.91777 1.73876 1.7004
6 0.06122 0.39987 0.54112 0.4793 0.58301
Zn dosis, ppm 2500
Foder/gang, kg 0.35
vægt, kg 10
Zn dosis, mg/kg 875
Oxytertracyclin Jejunum
Dosis mg/kg #VALUE! #VALUE!
#VALUE!
#VALUE!
#VALUE!
#VALUE!
#VALUE!
#VALUE!
#VALUE!
kaFVD/ka-ke enkeT enketi ekeT enkaT ekati ekaT Plasma Tissue
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
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#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
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#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
Colon Caecum
171.044 604.646
1135.32
436.503 78.708
43.8104 9.7317
87.8152 19.9664
2.9722 1.8359
2.8816 1.83835
0.47058 0.26127
Colon Days MIC
#VALUE! 0.25 0.00
#VALUE! 0.5 0.00
#VALUE! 1 0.00
#VALUE! 1.5 0.00
#VALUE! 2 0.00
#VALUE! 3 0.00
#VALUE! 4 0.00
#VALUE! 6 0.00
MIC Days Plasmai Tissuei
0.00 0.04 #VALUE! #VALUE!
0.00 0.08 #VALUE! #VALUE!
0.00 0.17 #VALUE! #VALUE!
0.00 0.25 #VALUE! #VALUE!
0.00 0.50 #VALUE! #VALUE!
0.00 0.54
0.00 0.58
0.00 0.67
0.00 0.75
0.00 1.00
0.00 1.04
0.00 1.08
0.00 1.17
0.00 1.25
0.00 1.50
0.00 1.54
0.00 1.58
0.00 1.67
0.00 1.75
0.00 2.00
0.00 2.04
0.00 2.08
0.00 2.17
0.00 2.25
0.00 2.50
Reference: Shen J et al. AJVR 66, 1071, 2005
Tilmicosin, PO TYPE IN
MIC, µg/ml 3.00 0
postantibiotic time, hours 2.40 100.0
dosing interval, hours 12.00
tissue/plasma ratio 6.00
weight of animal, kg 50.00
number of animals 1.00
10.0
treatment period, 24 hours 3.00
Conc. (mcg/ml)
drug concentration, mg/ml or mg/g 100.00
product price, kr./ml or g 0.00
RESULTS
initial dose, [mg/kg] [ml or g/animal] 19.97 9.99 1.0
maintenance dose, [mg/kg] [ml;g/animal] 17.52 8.76
drugs in all, ml or g 53.79
expenses, kr. 0.00
0.1
CONCENTRATIONS
maximum plasma concentration, mg/l 2.00
minimum plasma concentration, mg/l 0.58
maximum tissue concentration, mg/l 12.00
minimum tissue concentration, mg/l 3.50
drugs ml or g per animal 53.79
recommended dose, mg/kg 20.00
withdrawal time slaughter, 24 hours 21.00
prolongation of withdrawal time from plasma, hours -0.01
t1/2el, hours 3.85
t1/2ab, hours 1.73
F/V 0.15
F, % 0.00
V, L/kg #1334
a) relevant for Lawsonia
1 1 2 2 3 3
Plasma
Tissue
MIC
Plasmai
Tissuei
Days
Time n Hours
Cmic 0.50
ka 0.40 1 1 1
ke 0.18 2 1 2
4 1 4
aT 0.01 6 1 6
eT 0.12 12 1 12
tmax 2.20 1 2 13
etmax 0.67 2 2 14
Cmin 0.32 4 2 16
Dv 9.75 6 2 18
Cmax 1.11 12 2 24
Dp 11.11 1 3 25
cmaxcmic 2.23 2 3 26
DpFakt 19.97 4 3 28
DvFakt 17.52 6 3 30
CmaxFakt 2.00 12 3 36
CminFakt 0.58 1 4 37
faktor,MIC 4.00 2 4 38
4 4 40
6 4 42
Dpkorrekt 19.97 12 4 48
1 5 49
Dvkorrekt 17.52 2 5 50
4 5 52
Cmaxkorrekt 2.00 6 5 54
Cminkorrekt 0.58 12 5 60
medicin dyr 53.79
medicin i alt 53.79
pris 0.00
Time Stomac Duodenum Jejunum_1 Jejunum_2 Ileum
days ug/g
0.25 756.868 21.368 143.256 358.77 75.842
0.5 11.56 8.62 12.41 157.06 28.91
1 2.561 5.533 2.772 5.729 4.514
1.5 0.2473 1.1572 0.9329 1.3344 2.7235
2 2.3668 3.0654 3.0109 4.6475 2.4363
3 0.182 1.0628 1.0638 1.411 1.7622
4 0.4717 0.7534 0.91777 1.73876 1.7004
6 0.06122 0.39987 0.54112 0.4793 0.58301
Zn dosis, ppm 2500
Foder/gang, kg 0.35
vægt, kg 10
Zn dosis, mg/kg 875
Oxytertracyclin Jejunum
Dosis mg/kg 17.52 7.18428
3.14509
0.11472
0.02672
0.09307
0.02825
0.03482
0.0096
kaFVD/ka-ke enkeT enketi ekeT enkaT ekati ekaT Plasma Tissue
4.78 0.12 0.84 0.12 0.01 0.67 0.01 0.79 4.73
4.78 0.12 0.70 0.12 0.01 0.45 0.01 1.19 7.12
4.78 0.12 0.49 0.12 0.01 0.20 0.01 1.36 8.17
4.78 0.12 0.34 0.12 0.01 0.09 0.01 1.19 7.14
4.78 0.12 0.12 0.12 0.01 0.01 0.01 0.51 3.07
4.78 0.01 0.84 0.12 0.00 0.67 0.01 1.22 7.33
4.78 0.01 0.70 0.12 0.00 0.45 0.01 1.55 9.32
4.78 0.01 0.49 0.12 0.00 0.20 0.01 1.62 9.73
4.78 0.01 0.34 0.12 0.00 0.09 0.01 1.37 8.24
4.78 0.01 0.12 0.12 0.00 0.01 0.01 0.58 3.45
4.78 0.00 0.84 0.12 0.00 0.67 0.01 1.28 7.65
4.78 0.00 0.70 0.12 0.00 0.45 0.01 1.60 9.59
4.78 0.00 0.49 0.12 0.00 0.20 0.01 1.65 9.91
4.78 0.00 0.34 0.12 0.00 0.09 0.01 1.39 8.37
4.78 0.00 0.12 0.12 0.00 0.01 0.01 0.58 3.49
4.78 0.00 0.84 0.12 0.00 0.67 0.01 1.28 7.69
4.78 0.00 0.70 0.12 0.00 0.45 0.01 1.60 9.62
4.78 0.00 0.49 0.12 0.00 0.20 0.01 1.66 9.94
4.78 0.00 0.34 0.12 0.00 0.09 0.01 1.40 8.38
4.78 0.00 0.12 0.12 0.00 0.01 0.01 0.58 3.50
4.78 0.00 0.84 0.12 0.00 0.67 0.01 1.28 7.69
4.78 0.00 0.70 0.12 0.00 0.45 0.01 1.60 9.62
4.78 0.00 0.49 0.12 0.00 0.20 0.01 1.66 9.94
4.78 0.00 0.34 0.12 0.00 0.09 0.01 1.40 8.38
4.78 0.00 0.12 0.12 0.00 0.01 0.01 0.58 3.50
Colon Caecum
171.044 604.646
1135.32
436.503 78.708
43.8104 9.7317
87.8152 19.9664
2.9722 1.8359
2.8816 1.83835
0.47058 0.26127
Colon Days MIC
3.42511344 0.25 0.00
22.7344998 0.5 0.00
8.74086369 1 0.00
0.87729233 1.5 0.00
1.75847748 2 0.00
0.05951756 3 0.00
0.05770332 4 0.00
0.00942325 6 0.00
MIC Days Plasmai Tissuei
3.00 0.04 0.90 5.39
3.00 0.08 1.35 8.12
3.00 0.17 1.55 9.31
3.00 0.25 1.36 8.13
3.00 0.50 0.58 3.50
3.00 0.54
3.00 0.58
3.00 0.67
3.00 0.75
3.00 1.00
3.00 1.04
3.00 1.08
3.00 1.17
3.00 1.25
3.00 1.50
3.00 1.54
3.00 1.58
3.00 1.67
3.00 1.75
3.00 2.00
3.00 2.04
3.00 2.08
3.00 2.17
3.00 2.25
3.00 2.50
Reference:
Tulathromycin, IM TYPE IN
MIC, µg/ml 3.50 0
postantibiotic time, hours 0.00 10.0
dosing interval, hours 72.00
tissue/plasma ratio 51.00
weight of animal, kg 50.00
number of animals 1.00
treatment period, 24 hours 3.00 1.0
Conc. (mcg/ml)
drug concentration, mg/ml or mg/g 100.00
product price, kr./ml or g 0.00
RESULTS
initial dose, [mg/kg] [ml or g/animal] 2.54 1.27 0.1
maintenance dose, [mg/kg] [ml;g/animal] 1.55 0.78
drugs in all, ml or g 1.27
expenses, kr. 0.00
0.0
CONCENTRATIONS
maximum plasma concentration, mg/l 0.15
minimum plasma concentration, mg/l 0.07
maximum tissue concentration, mg/l 7.77
minimum tissue concentration, mg/l 3.50
drugs ml or g per animal 1.27
recommended dose, mg/kg 2.50
withdrawal time slaughter, 24 hours 33.00
prolongation of withdrawal time from plasma, hours 1.24
t1/2el, hours 52.98
t1/2ab, hours 4.70
F/V 0.06
F, %
2 4 6 8 10 12 14 16
Plasma
Tissue
MIC
Plasmai
Tissuei
Days
Time n Hours
Cmic 0.07
ka 0.15 6 1 6
ke 0.01 12 1 12
24 1 24
aT 0.00 36 1 36
eT 0.39 72 1 72
tmax 3.94 6 2 78
etmax 0.95 12 2 84
Cmin 0.07 24 2 96
Dv 1.55 36 2 108
Cmax 0.15 72 2 144
Dp 2.54 6 3 150
cmaxcmic 2.22 12 3 156
DpFakt 2.29 24 3 168
DvFakt 1.40 36 3 180
CmaxFakt 0.14 72 3 216
CminFakt 0.06 6 4 222
faktor,MIC 2.00 12 4 228
24 4 240
36 4 252
Dpkorrekt 2.54 72 4 288
6 5 294
Dvkorrekt 1.55 12 5 300
24 5 312
Cmaxkorrekt 0.15 36 5 324
Cminkorrekt 0.07 72 5 360
medicin dyr 1.27
medicin i alt 1.27
pris 0.00
Time Stomac Duodenum Jejunum_1 Jejunum_2 Ileum
days ug/g
0.25 756.868 21.368 143.256 358.77 75.842
0.5 11.56 8.62 12.41 157.06 28.91
1 2.561 5.533 2.772 5.729 4.514
1.5 0.2473 1.1572 0.9329 1.3344 2.7235
2 2.3668 3.0654 3.0109 4.6475 2.4363
3 0.182 1.0628 1.0638 1.411 1.7622
4 0.4717 0.7534 0.91777 1.73876 1.7004
6 0.06122 0.39987 0.54112 0.4793 0.58301
Zn dosis, ppm 2500
Foder/gang, kg 0.35
vægt, kg 10
Zn dosis, mg/kg 875
Oxytertracyclin Jejunum
Dosis mg/kg 1.55 0.63558
0.27824
0.01015
0.00236
0.00823
0.0025
0.00308
0.00085
kaFVD/ka-ke enkeT enketi ekeT enkaT ekati ekaT Plasma Tissue
0.11 0.39 0.92 0.39 0.00 0.41 0.00 0.05 2.80
0.11 0.39 0.85 0.39 0.00 0.17 0.00 0.07 3.75
0.11 0.39 0.73 0.39 0.00 0.03 0.00 0.08 3.84
0.11 0.39 0.62 0.39 0.00 0.00 0.00 0.07 3.39
0.11 0.39 0.39 0.39 0.00 0.00 0.00 0.04 2.14
0.11 0.15 0.92 0.39 0.00 0.41 0.00 0.09 4.78
0.11 0.15 0.85 0.39 0.00 0.17 0.00 0.11 5.57
0.11 0.15 0.73 0.39 0.00 0.03 0.00 0.11 5.40
0.11 0.15 0.62 0.39 0.00 0.00 0.00 0.09 4.73
0.11 0.15 0.39 0.39 0.00 0.00 0.00 0.06 2.97
0.11 0.06 0.92 0.39 0.00 0.41 0.00 0.11 5.55
0.11 0.06 0.85 0.39 0.00 0.17 0.00 0.12 6.28
0.11 0.06 0.73 0.39 0.00 0.03 0.00 0.12 6.01
0.11 0.06 0.62 0.39 0.00 0.00 0.00 0.10 5.25
0.11 0.06 0.39 0.39 0.00 0.00 0.00 0.06 3.29
0.11 0.02 0.92 0.39 0.00 0.41 0.00 0.11 5.85
0.11 0.02 0.85 0.39 0.00 0.17 0.00 0.13 6.56
0.11 0.02 0.73 0.39 0.00 0.03 0.00 0.12 6.25
0.11 0.02 0.62 0.39 0.00 0.00 0.00 0.11 5.45
0.11 0.02 0.39 0.39 0.00 0.00 0.00 0.07 3.42
0.11 0.01 0.92 0.39 0.00 0.41 0.00 0.12 5.96
0.11 0.01 0.85 0.39 0.00 0.17 0.00 0.13 6.67
0.11 0.01 0.73 0.39 0.00 0.03 0.00 0.12 6.34
0.11 0.01 0.62 0.39 0.00 0.00 0.00 0.11 5.53
0.11 0.01 0.39 0.39 0.00 0.00 0.00 0.07 3.47
Colon Caecum
171.044 604.646
1135.32
436.503 78.708
43.8104 9.7317
87.8152 19.9664
2.9722 1.8359
2.8816 1.83835
0.47058 0.26127
Colon Days MIC
0.30301466 0.25 0.00
2.01128717 0.5 0.00
0.77329113 1 0.00
0.07761274 1.5 0.00
0.15556987 2 0.00
0.00526543 3 0.00
0.00510493 4 0.00
0.00083366 6 0.00
MIC Days Plasmai Tissuei
3.50 0.25 0.09 4.59
3.50 0.50 0.12 6.14
3.50 1.00 0.12 6.30
3.50 1.50 0.11 5.56
3.50 3.00 0.07 3.50
3.50 3.25
3.50 3.50
3.50 4.00
3.50 4.50
3.50 6.00
3.50 6.25
3.50 6.50
3.50 7.00
3.50 7.50
3.50 9.00
3.50 9.25
3.50 9.50
3.50 10.00
3.50 10.50
3.50 12.00
3.50 12.25
3.50 12.50
3.50 13.00
3.50 13.50
3.50 15.00
Reference:
NO DATA PHARMAKOKINETIC DATA AVAILABLE
Lincomycin, IM TYPE IN
MIC, µg/ml 0.25 0
postantibiotic time, hours 2.40 1.0
dosing interval, hours 12.00
tissue/plasma ratio 1.00
weight of animal, kg 50.00
number of animals 1.00
treatment period, 24 hours 3.00
Conc. (mcg/ml)
drug concentration, mg/ml or mg/g 100.00
product price, kr./ml or g 0.00
RESULTS
initial dose, [mg/kg] [ml or g/animal] #VALUE! #VALUE!
maintenance dose, [mg/kg] [ml;g/animal] #VALUE! #VALUE!
drugs in all, ml or g #VALUE!
expenses, kr. #VALUE!
0.1
CONCENTRATIONS
maximum plasma concentration, mg/l #VALUE!
minimum plasma concentration, mg/l #VALUE!
maximum tissue concentration, mg/l #VALUE!
minimum tissue concentration, mg/l #VALUE!
drugs ml or g per animal #VALUE!
recommended dose, mg/kg 10.00
withdrawal time slaughter, 24 hours 6.00
prolongation of withdrawal time from plasma, hours #VALUE!
t1/2el, hours NO DATA
t1/2ab, hours NO DATA
F/V NO DATA
F, %
V, L/kg
1 1 2 2 3 3
Plasma
Tissue
MIC
Plasmai
Tissuei
Days
Time n Hours
Cmic 0.25
ka #VALUE! 1 1 1
ke #VALUE! 2 1 2
4 1 4
aT #VALUE! 6 1 6
eT #VALUE! 12 1 12
tmax #VALUE! 1 2 13
etmax #VALUE! 2 2 14
Cmin #VALUE! 4 2 16
Dv #VALUE! 6 2 18
Cmax #VALUE! 12 2 24
Dp #VALUE! 1 3 25
cmaxcmic #VALUE! 2 3 26
DpFakt #VALUE! 4 3 28
DvFakt #VALUE! 6 3 30
CmaxFakt #VALUE! 12 3 36
CminFakt #VALUE! 1 4 37
faktor,MIC 4.00 2 4 38
4 4 40
6 4 42
Dpkorrekt #VALUE! 12 4 48
1 5 49
Dvkorrekt #VALUE! 2 5 50
4 5 52
Cmaxkorrekt #VALUE! 6 5 54
Cminkorrekt #VALUE! 12 5 60
medicin dyr #VALUE!
medicin i alt #VALUE!
pris #VALUE!
Time Stomac Duodenum Jejunum_1 Jejunum_2 Ileum
days ug/g
0.25 756.868 21.368 143.256 358.77 75.842
0.5 11.56 8.62 12.41 157.06 28.91
1 2.561 5.533 2.772 5.729 4.514
1.5 0.2473 1.1572 0.9329 1.3344 2.7235
2 2.3668 3.0654 3.0109 4.6475 2.4363
3 0.182 1.0628 1.0638 1.411 1.7622
4 0.4717 0.7534 0.91777 1.73876 1.7004
6 0.06122 0.39987 0.54112 0.4793 0.58301
Zn dosis, ppm 2500
Foder/gang, kg 0.35
vægt, kg 10
Zn dosis, mg/kg 875
Lincosamin Jejunum
Dosis mg/kg #VALUE! #VALUE!
#VALUE!
#VALUE!
#VALUE!
#VALUE!
#VALUE!
#VALUE!
#VALUE!
kaFVD/ka-ke enkeT enketi ekeT enkaT ekati ekaT Plasma Tissue
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
Colon Caecum
171.044 604.646
1135.32
436.503 78.708
43.8104 9.7317
87.8152 19.9664
2.9722 1.8359
2.8816 1.83835
0.47058 0.26127
Colon Days MIC
#VALUE! 0.25 0.00
#VALUE! 0.5 0.00
#VALUE! 1 0.00
#VALUE! 1.5 0.00
#VALUE! 2 0.00
#VALUE! 3 0.00
#VALUE! 4 0.00
#VALUE! 6 0.00
MIC Days Plasmai Tissuei
0.25 0.04 #VALUE! #VALUE!
0.25 0.08 #VALUE! #VALUE!
0.25 0.17 #VALUE! #VALUE!
0.25 0.25 #VALUE! #VALUE!
0.25 0.50 #VALUE! #VALUE!
0.25 0.54
0.25 0.58
0.25 0.67
0.25 0.75
0.25 1.00
0.25 1.04
0.25 1.08
0.25 1.17
0.25 1.25
0.25 1.50
0.25 1.54
0.25 1.58
0.25 1.67
0.25 1.75
0.25 2.00
0.25 2.04
0.25 2.08
0.25 2.17
0.25 2.25
0.25 2.50
Reference: Nielsen P, Gyrd-Hansen, N: J.vet.Pharmacol.Therap.
Lincomycin, PO TYPE IN
MIC extracellular, relevant for Lawsonia 32.00
MIC, µg/ml 0.25
postantibiotic time, hours 2.40
dosing interval, hours 12.00
tissue/plasma ratio 1.50
10.0
weight of animal, kg 50.00
number of animals 1.00
treatment period, 24 hours 3.00
Conc. (mcg/ml)
drug concentration, mg/ml or mg/g 100.00
product price, kr./ml or g 0.00
1.0
RESULTS
initial dose, [mg/kg] [ml or g/animal] 7.38 3.69
maintenance dose, [mg/kg] [ml;g/animal] 6.70 3.35
drugs in all, ml or g 20.44
expenses, kr. 0.00
0.1
CONCENTRATIONS
maximum plasma concentration, mg/l 0.67
minimum plasma concentration, mg/l 1.03
maximum tissue concentration, mg/l 1.00 0
minimum tissue concentration, mg/l 1.55 100.0
drugs ml or g per animal 20.44
recommended dose, mg/kg 5.00
10.0
withdrawal time slaughter, 24 hours 1.00
prolongation of withdrawal time from plasma, hours 1.55
1.0
Conc. (mcg/ml)
t1/2el, hours 2.75
t1/2ab, hours 2.70
F/V 0.37 0.1
F 40.00
0.0
0.0
0 1 1 2 2 3 3
10.0 Plasma
Tissue
MIC
Plasmai
Tissuei
1.0
0.1
Days
1 2 3 4 5 6 7
Jenunum
Colon
MIC
Days
Time n Hours
Cmic 0.17
ka 0.26 1 1 1
ke 0.25 2 1 2
4 1 4
aT 0.05 6 1 6
eT 0.05 12 1 12
tmax 5.44 1 2 13
etmax 0.25 2 2 14
Cmin 0.09 4 2 16
Dv 1.52 6 2 18
Cmax 0.15 12 2 24
Dp 1.68 1 3 25
cmaxcmic 0.91 2 3 26
DpFakt 7.38 4 3 28
DvFakt 6.70 6 3 30
CmaxFakt 0.67 12 3 36
CminFakt 1.03 1 4 37
faktor,MIC 4.00 2 4 38
4 4 40
6 4 42
Dpkorrekt 7.38 12 4 48
1 5 49
Dvkorrekt 6.70 2 5 50
4 5 52
Cmaxkorrekt 0.67 6 5 54
Cminkorrekt 1.03 12 5 60
medicin dyr 20.44
medicin i alt 20.44
pris 0.00
Time Stomac Duodenum Jejunum_1 Jejunum_2 Ileum
days ug/g
0.25 756.868 21.368 143.256 358.77 75.842
0.5 11.56 8.62 12.41 157.06 28.91
1 2.561 5.533 2.772 5.729 4.514
1.5 0.2473 1.1572 0.9329 1.3344 2.7235
2 2.3668 3.0654 3.0109 4.6475 2.4363
3 0.182 1.0628 1.0638 1.411 1.7622
4 0.4717 0.7534 0.91777 1.73876 1.7004
6 0.06122 0.39987 0.54112 0.4793 0.58301
Zn dosis, ppm 2500
Foder/gang, kg 0.35
vægt, kg 10
Zn dosis, mg/kg 875
Lincomycin Jejunum
Dosis mg/kg 4.02 1.64833
0.72159
0.02632
0.00613
0.02135
0.00648
0.00799
0.0022
kaFVD/ka-ke enkeT enketi ekeT enkaT ekati ekaT Plasma Tissue
145.19 0.05 0.78 0.05 0.05 0.77 0.05 0.50 0.74
145.19 0.05 0.60 0.05 0.05 0.60 0.05 0.77 1.16
145.19 0.05 0.36 0.05 0.05 0.36 0.05 0.93 1.39
145.19 0.05 0.22 0.05 0.05 0.21 0.05 0.84 1.25
145.19 0.05 0.05 0.05 0.05 0.05 0.05 0.36 0.55
145.19 0.00 0.78 0.05 0.00 0.77 0.05 0.80 1.20
145.19 0.00 0.60 0.05 0.00 0.60 0.05 1.03 1.54
145.19 0.00 0.36 0.05 0.00 0.36 0.05 1.10 1.65
145.19 0.00 0.22 0.05 0.00 0.21 0.05 0.95 1.43
145.19 0.00 0.05 0.05 0.00 0.05 0.05 0.40 0.60
145.19 0.00 0.78 0.05 0.00 0.77 0.05 0.83 1.25
145.19 0.00 0.60 0.05 0.00 0.60 0.05 1.05 1.57
145.19 0.00 0.36 0.05 0.00 0.36 0.05 1.12 1.67
145.19 0.00 0.22 0.05 0.00 0.21 0.05 0.96 1.45
145.19 0.00 0.05 0.05 0.00 0.05 0.05 0.40 0.60
145.19 0.00 0.78 0.05 0.00 0.77 0.05 0.83 1.25
145.19 0.00 0.60 0.05 0.00 0.60 0.05 1.05 1.57
145.19 0.00 0.36 0.05 0.00 0.36 0.05 1.12 1.68
145.19 0.00 0.22 0.05 0.00 0.21 0.05 0.96 1.45
145.19 0.00 0.05 0.05 0.00 0.05 0.05 0.40 0.60
145.19 0.00 0.78 0.05 0.00 0.77 0.05 0.83 1.25
145.19 0.00 0.60 0.05 0.00 0.60 0.05 1.05 1.57
145.19 0.00 0.36 0.05 0.00 0.36 0.05 1.12 1.68
145.19 0.00 0.22 0.05 0.00 0.21 0.05 0.96 1.45
145.19 0.00 0.05 0.05 0.00 0.05 0.05 0.40 0.60
Colon Caecum
171.044 604.646
1135.32
436.503 78.708
43.8104 9.7317
87.8152 19.9664
2.9722 1.8359
2.8816 1.83835
0.47058 0.26127
Colon Days MIC
0.78584137 0.25 32.00
5.21609311 0.5 32.00
2.00546127 1 32.00
0.20128169 1.5 32.00
0.40345652 2 32.00
0.01365542 3 32.00
0.01323917 4 32.00
0.00216202 6 32.00
MIC Days Plasmai Tissuei
0.25 0.04 0.55 0.82
0.25 0.08 0.85 1.27
0.25 0.17 1.02 1.53
0.25 0.25 0.92 1.38
0.25 0.50 0.40 0.60
0.25 0.54
0.25 0.58
0.25 0.67
0.25 0.75
0.25 1.00
0.25 1.04
0.25 1.08
0.25 1.17
0.25 1.25
0.25 1.50
0.25 1.54
0.25 1.58
0.25 1.67
0.25 1.75
0.25 2.00
0.25 2.04
0.25 2.08
0.25 2.17
0.25 2.25
0.25 2.50
Reference: Forster et al 1982
Tiamulin, IM TYPE IN
MIC, µg/ml 1.50 0
postantibiotic time, hours 2.40 10.0
dosing interval, hours 12.00
tissue/plasma ratio 8.00
weight of animal, kg 50.00
number of animals 1.00
treatment period, 24 hours 3.00
Conc. (mcg/ml)
drug concentration, mg/ml or mg/g 100.00
product price, kr./ml or g 0.00 1.0
RESULTS
initial dose, [mg/kg] [ml or g/animal] 12.11 6.06
maintenance dose, [mg/kg] [ml;g/animal] 8.26 4.13
drugs in all, ml or g 26.71
expenses, kr. 0.00
0.1
CONCENTRATIONS
maximum plasma concentration, mg/l 0.75
minimum plasma concentration, mg/l 0.33
maximum tissue concentration, mg/l 6.00
minimum tissue concentration, mg/l 2.64
drugs ml or g per animal 26.71
recommended dose, mg/kg 20.00
withdrawal time slaughter, 24 hours 30.00
prolongation of withdrawal time from plasma, hours -5.25
t1/2el, hours 7.26
t1/2ab, hours 0.85
F/V 0.08
F, %
1 1 2 2 3 3
Plasma
Tissue
MIC
Plasmai
Tissuei
Days
Time n Hours
Cmic 0.19
ka 0.81 1 1 1
ke 0.10 2 1 2
4 1 4
aT 0.00 6 1 6
eT 0.32 12 1 12
tmax 2.09 1 2 13
etmax 0.82 2 2 14
Cmin 0.15 4 2 16
Dv 3.73 6 2 18
Cmax 0.34 12 2 24
Dp 5.47 1 3 25
cmaxcmic 1.81 2 3 26
DpFakt 12.11 4 3 28
DvFakt 8.26 6 3 30
CmaxFakt 0.75 12 3 36
CminFakt 0.33 1 4 37
faktor,MIC 4.00 2 4 38
4 4 40
6 4 42
Dpkorrekt 12.11 12 4 48
1 5 49
Dvkorrekt 8.26 2 5 50
4 5 52
Cmaxkorrekt 0.75 6 5 54
Cminkorrekt 0.33 12 5 60
medicin dyr 26.71
medicin i alt 26.71
pris 0.00
kaFVD/ka-ke enkeT enketi ekeT enkaT ekati ekaT Plasma Tissue
0.71 0.32 0.91 0.32 0.00 0.44 0.00 0.33 2.63
0.71 0.32 0.83 0.32 0.00 0.20 0.00 0.45 3.56
0.71 0.32 0.68 0.32 0.00 0.04 0.00 0.46 3.64
0.71 0.32 0.56 0.32 0.00 0.01 0.00 0.39 3.15
0.71 0.32 0.32 0.32 0.00 0.00 0.00 0.23 1.80
0.71 0.10 0.91 0.32 0.00 0.44 0.00 0.53 4.27
0.71 0.10 0.83 0.32 0.00 0.20 0.00 0.63 5.05
0.71 0.10 0.68 0.32 0.00 0.04 0.00 0.61 4.87
0.71 0.10 0.56 0.32 0.00 0.01 0.00 0.52 4.17
0.71 0.10 0.32 0.32 0.00 0.00 0.00 0.30 2.37
0.71 0.03 0.91 0.32 0.00 0.44 0.00 0.60 4.79
0.71 0.03 0.83 0.32 0.00 0.20 0.00 0.69 5.52
0.71 0.03 0.68 0.32 0.00 0.04 0.00 0.66 5.26
0.71 0.03 0.56 0.32 0.00 0.01 0.00 0.56 4.49
0.71 0.03 0.32 0.32 0.00 0.00 0.00 0.32 2.56
0.71 0.01 0.91 0.32 0.00 0.44 0.00 0.62 4.95
0.71 0.01 0.83 0.32 0.00 0.20 0.00 0.71 5.67
0.71 0.01 0.68 0.32 0.00 0.04 0.00 0.67 5.39
0.71 0.01 0.56 0.32 0.00 0.01 0.00 0.57 4.59
0.71 0.01 0.32 0.32 0.00 0.00 0.00 0.33 2.61
0.71 0.00 0.91 0.32 0.00 0.44 0.00 0.63 5.01
0.71 0.00 0.83 0.32 0.00 0.20 0.00 0.71 5.72
0.71 0.00 0.68 0.32 0.00 0.04 0.00 0.68 5.43
0.71 0.00 0.56 0.32 0.00 0.01 0.00 0.58 4.62
0.71 0.00 0.32 0.32 0.00 0.00 0.00 0.33 2.63
MIC Days Plasmai Tissuei
1.50 0.04 0.48 3.86
1.50 0.08 0.65 5.22
1.50 0.17 0.67 5.34
1.50 0.25 0.58 4.62
1.50 0.50 0.33 2.64
1.50 0.54
1.50 0.58
1.50 0.67
1.50 0.75
1.50 1.00
1.50 1.04
1.50 1.08
1.50 1.17
1.50 1.25
1.50 1.50
1.50 1.54
1.50 1.58
1.50 1.67
1.50 1.75
1.50 2.00
1.50 2.04
1.50 2.08
1.50 2.17
1.50 2.25
1.50 2.50
Reference: Laber Schütze 1981
Tiamulin, PO TYPE IN
MIC extracellular, relevant for Lawsonia 2.00
MIC, µg/ml 0.10 0
postantibiotic time, hours 2.40 1.0
dosing interval, hours 12.00
tissue/plasma ratio 0.60
weight of animal, kg 50.00
number of animals 1.00
treatment period, 24 hours 3.00
Conc. (mcg/ml)
drug concentration, mg/ml or mg/g 100.00
product price, kr./ml or g 0.00 0.1
RESULTS
initial dose, [mg/kg] [ml or g/animal] 8.56 4.28
maintenance dose, [mg/kg] [ml;g/animal] 7.75 3.88
drugs in all, ml or g 23.66
expenses, kr. 0.00
0.0
CONCENTRATIONS
maximum plasma concentration, mg/l 0.67
minimum plasma concentration, mg/l 0.14
maximum tissue concentration, mg/l 0.40 0
minimum tissue concentration, mg/l 0.08 10.0
drugs ml or g per animal 23.66
recommended dose, mg/kg 8.00
1.0
withdrawal time slaughter, 24 hours 6.00
prolongation of withdrawal time from plasma, hours 0.34
0.1
Conc. (mcg/ml)
t1/2el, hours 3.51
t1/2ab, hours 1.17
F/V 0.11 0.0
F, % 90.00
0.0
0.0
1 1 2 2 3 3
Plasma
Tissue
MIC
Plasmai
Tissuei
Days
1 2 3 4 5 6 7
Jenunum
Colon
MIC
Days
Time n Hours
Cmic 0.17
ka 0.59 1 1 1
ke 0.20 2 1 2
4 1 4
aT 0.00 6 1 6
eT 0.09 12 1 12
tmax 1.93 1 2 13
etmax 0.68 2 2 14
Cmin 0.10 4 2 16
Dv 5.91 6 2 18
Cmax 0.51 12 2 24
Dp 6.53 1 3 25
cmaxcmic 3.05 2 3 26
DpFakt 8.56 4 3 28
DvFakt 7.75 6 3 30
CmaxFakt 0.67 12 3 36
CminFakt 0.14 1 4 37
faktor,MIC 4.00 2 4 38
4 4 40
6 4 42
Dpkorrekt 8.56 12 4 48
1 5 49
Dvkorrekt 7.75 2 5 50
4 5 52
Cmaxkorrekt 0.67 6 5 54
Cminkorrekt 0.14 12 5 60
medicin dyr 23.66
medicin i alt 23.66
pris 0.00
Time Stomac Duodenum Jejunum_1 Jejunum_2 Ileum
days ug/g
0.25 756.868 21.368 143.256 358.77 75.842
0.5 11.56 8.62 12.41 157.06 28.91
1 2.561 5.533 2.772 5.729 4.514
1.5 0.2473 1.1572 0.9329 1.3344 2.7235
2 2.3668 3.0654 3.0109 4.6475 2.4363
3 0.182 1.0628 1.0638 1.411 1.7622
4 0.4717 0.7534 0.91777 1.73876 1.7004
6 0.06122 0.39987 0.54112 0.4793 0.58301
Zn dosis, ppm 2500
Foder/gang, kg 0.35
vægt, kg 10
Zn dosis, mg/kg 875
Tiamulin Jejunum
Dosis mg/kg 0.78 0.31786
0.13915
0.00508
0.00118
0.00412
0.00125
0.00154
0.00042
kaFVD/ka-ke enkeT enketi ekeT enkaT ekati ekaT Plasma Tissue
1.33 0.09 0.82 0.09 0.00 0.55 0.00 0.36 0.21
1.33 0.09 0.67 0.09 0.00 0.31 0.00 0.49 0.29
1.33 0.09 0.45 0.09 0.00 0.09 0.00 0.48 0.29
1.33 0.09 0.31 0.09 0.00 0.03 0.00 0.37 0.22
1.33 0.09 0.09 0.09 0.00 0.00 0.00 0.12 0.07
1.33 0.01 0.82 0.09 0.00 0.55 0.00 0.46 0.27
1.33 0.01 0.67 0.09 0.00 0.31 0.00 0.57 0.34
1.33 0.01 0.45 0.09 0.00 0.09 0.00 0.53 0.32
1.33 0.01 0.31 0.09 0.00 0.03 0.00 0.41 0.24
1.33 0.01 0.09 0.09 0.00 0.00 0.00 0.13 0.08
1.33 0.00 0.82 0.09 0.00 0.55 0.00 0.47 0.28
1.33 0.00 0.67 0.09 0.00 0.31 0.00 0.58 0.35
1.33 0.00 0.45 0.09 0.00 0.09 0.00 0.54 0.32
1.33 0.00 0.31 0.09 0.00 0.03 0.00 0.41 0.25
1.33 0.00 0.09 0.09 0.00 0.00 0.00 0.14 0.08
1.33 0.00 0.82 0.09 0.00 0.55 0.00 0.47 0.28
1.33 0.00 0.67 0.09 0.00 0.31 0.00 0.58 0.35
1.33 0.00 0.45 0.09 0.00 0.09 0.00 0.54 0.32
1.33 0.00 0.31 0.09 0.00 0.03 0.00 0.41 0.25
1.33 0.00 0.09 0.09 0.00 0.00 0.00 0.14 0.08
1.33 0.00 0.82 0.09 0.00 0.55 0.00 0.47 0.28
1.33 0.00 0.67 0.09 0.00 0.31 0.00 0.58 0.35
1.33 0.00 0.45 0.09 0.00 0.09 0.00 0.54 0.32
1.33 0.00 0.31 0.09 0.00 0.03 0.00 0.41 0.25
1.33 0.00 0.09 0.09 0.00 0.00 0.00 0.14 0.08
Colon Caecum
171.044 604.646
1135.32
436.503 78.708
43.8104 9.7317
87.8152 19.9664
2.9722 1.8359
2.8816 1.83835
0.47058 0.26127
Colon Days MIC
0.15154237 0.25 2.00
1.00587615 0.5 2.00
0.38673498 1 2.00
0.03881534 1.5 2.00
0.07780292 2 2.00
0.00263332 3 2.00
0.00255305 4 2.00
0.00041693 6 2.00
MIC Days Plasmai Tissuei
0.10 0.04 0.39 0.24
0.10 0.08 0.54 0.32
0.10 0.17 0.53 0.32
0.10 0.25 0.41 0.24
0.10 0.50 0.14 0.08
0.10 0.54
0.10 0.58
0.10 0.67
0.10 0.75
0.10 1.00
0.10 1.04
0.10 1.08
0.10 1.17
0.10 1.25
0.10 1.50
0.10 1.54
0.10 1.58
0.10 1.67
0.10 1.75
0.10 2.00
0.10 2.04
0.10 2.08
0.10 2.17
0.10 2.25
0.10 2.50
NO DATA PHARMAKOKINETIC DATA AVAILABLE
Valnemulin, PO TYPE IN
MIC extracellular, relevant for Lawsonia
MIC, µg/ml 0
postantibiotic time, hours 2.40 10.0
dosing interval, hours 12.00
tissue/plasma ratio
weight of animal, kg 50.00
number of animals 1.00
treatment period, 24 hours 3.00
Conc. (mcg/ml)
drug concentration, mg/ml or mg/g 100.00
product price, kr./ml or g 0.00
RESULTS
initial dose, [mg/kg] [ml or g/animal] #VALUE! #VALUE!
maintenance dose, [mg/kg] [ml;g/animal] #VALUE! #VALUE!
drugs in all, ml or g #VALUE!
expenses, kr. #VALUE!
1.0
CONCENTRATIONS
maximum plasma concentration, mg/l #VALUE!
minimum plasma concentration, mg/l #VALUE!
maximum tissue concentration, mg/l #VALUE! 0
minimum tissue concentration, mg/l #VALUE! 10.0
drugs ml or g per animal #VALUE!
recommended dose, mg/kg 4.00
withdrawal time slaughter, 24 hours 1.00
prolongation of withdrawal time from plasma, hours #VALUE!
Conc. (mcg/ml)
t1/2el, hours NO DATA
t1/2ab, hours NO DATA
F/V NO DATA
F, %
1.0
1 1 2 2 3 3
Plasma
Tissue
MIC
Plasmai
Tissuei
Days
1 2 3 4 5 6 7
Jenunum
Colon
MIC
Days
Time n Hours
Cmic #DIV/0!
ka #VALUE! 1 1 1
ke #VALUE! 2 1 2
4 1 4
aT #VALUE! 6 1 6
eT #VALUE! 12 1 12
tmax #VALUE! 1 2 13
etmax #VALUE! 2 2 14
Cmin #DIV/0! 4 2 16
Dv #DIV/0! 6 2 18
Cmax #VALUE! 12 2 24
Dp #DIV/0! 1 3 25
cmaxcmic #VALUE! 2 3 26
DpFakt #DIV/0! 4 3 28
DvFakt #DIV/0! 6 3 30
CmaxFakt #VALUE! 12 3 36
CminFakt #DIV/0! 1 4 37
faktor,MIC 4.00 2 4 38
4 4 40
6 4 42
Dpkorrekt #VALUE! 12 4 48
1 5 49
Dvkorrekt #VALUE! 2 5 50
4 5 52
Cmaxkorrekt #VALUE! 6 5 54
Cminkorrekt #VALUE! 12 5 60
medicin dyr #VALUE!
medicin i alt #VALUE!
pris #VALUE!
Time Stomac Duodenum Jejunum_1 Jejunum_2 Ileum
days ug/g
0.25 756.868 21.368 143.256 358.77 75.842
0.5 11.56 8.62 12.41 157.06 28.91
1 2.561 5.533 2.772 5.729 4.514
1.5 0.2473 1.1572 0.9329 1.3344 2.7235
2 2.3668 3.0654 3.0109 4.6475 2.4363
3 0.182 1.0628 1.0638 1.411 1.7622
4 0.4717 0.7534 0.91777 1.73876 1.7004
6 0.06122 0.39987 0.54112 0.4793 0.58301
Zn dosis, ppm 2500
Foder/gang, kg 0.35
vægt, kg 10
Zn dosis, mg/kg 875
Tiamulin Jejunum
Dosis mg/kg #VALUE! #VALUE!
#VALUE!
#VALUE!
#VALUE!
#VALUE!
#VALUE!
#VALUE!
#VALUE!
kaFVD/ka-ke enkeT enketi ekeT enkaT ekati ekaT Plasma Tissue
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
#VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE! #VALUE!
Colon Caecum
171.044 604.646
1135.32
436.503 78.708
43.8104 9.7317
87.8152 19.9664
2.9722 1.8359
2.8816 1.83835
0.47058 0.26127
Colon Days MIC
#VALUE! 0.25 0.00
#VALUE! 0.5 0.00
#VALUE! 1 0.00
#VALUE! 1.5 0.00
#VALUE! 2 0.00
#VALUE! 3 0.00
#VALUE! 4 0.00
#VALUE! 6 0.00
MIC Days Plasmai Tissuei
0.00 0.04 #VALUE! #VALUE!
0.00 0.08 #VALUE! #VALUE!
0.00 0.17 #VALUE! #VALUE!
0.00 0.25 #VALUE! #VALUE!
0.00 0.50 #VALUE! #VALUE!
0.00 0.54
0.00 0.58
0.00 0.67
0.00 0.75
0.00 1.00
0.00 1.04
0.00 1.08
0.00 1.17
0.00 1.25
0.00 1.50
0.00 1.54
0.00 1.58
0.00 1.67
0.00 1.75
0.00 2.00
0.00 2.04
0.00 2.08
0.00 2.17
0.00 2.25
0.00 2.50
