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Macrolides licosamines pleuromutilins

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					PHARMACOKINETICS, PIGS         Tylosin    Tylvalosin   Tilmicosin    Tulathromycin
INTRAVENOUS
distribution volume, l/kg
elimination half-life, hours
Reference

INTRAMUSCULAR
elimination half-life, hours       0.20
absorption half-life, hours        1.55
absorptionkoefficient, F/V         1.50
Reference

INTRAMUSCULAR, PROLONGATUM
elimination half-life, hours                                                   52.98
absorption half-life, hours                                                     4.70
absorptionkoefficient, F/V                                                      0.06
Reference                                                            Benchaoui et al. (2004)

ORAL
elimination half-life, hours       1.89 NO DATA               3.85
absorption half-life, hours        1.88 NO DATA               1.73
absorptionkoefficient, F/V         0.06 NO DATA               0.15
biotilgængelighed, %
Reference                      Laber                   Shen 2005
                 Lincomycin Tiamulin Valemulin




                 NO DATA              7.26
                 NO DATA              0.85
                 NO DATA              0.08
                                  #1590




Benchaoui et al. (2004)


                           2.75       3.51 NO DATA
                           2.70       1.17 NO DATA
                           0.37       0.11 NO DATA
                          40.00      90.00
                                  #1334
Tissue or secret/plasma ratio
                                          Tylosin     Tylvalosin
Lungs          total tissue                 4-5
               bronchial epithelium
               bronchial secret
Nose           nose epithelium
               nose secret
Milk           normal, pH: 6.6              3.0
               acute mastitis, pH: 7.2
Uterus         total tissue
               endometrium
               uterus secret
Intestine      total tissue
               intestine epithelium
               intestine secret
Peritonium     peritoneal fluid
Joints         synovial fluid
Brain          meninges
Exp. implan.   fluid

References                               3440, 4300
  Tilmicosin       Tulathromycin   Lincomycin   Tiamulin   Valnemulin
       6                 51                        25
                                                   8




                                      2.8




                                                  0.6




                                      0.5




Keles et al 2001        ?          250, 4930
Reference: Sauter RA et al. 1962

Tylosin, IM                                 TYPE IN
                                                       32.00
MIC, µg/ml                                              0.10                                 0
postantibiotic time, hours                              2.40                  10.0
dosing interval, hours                                 12.00
tissue/plasma ratio                                     5.00

weight of animal, kg                                   50.00
number of animals                                       1.00
treatment period, 24 hours                              3.00                           1.0




                                                                      Conc. (mcg/ml)
drug concentration, mg/ml or mg/g                     100.00
product price, kr./ml or g                              0.00

                                            RESULTS
initial dose, [mg/kg] [ml or g/animal]                 11.41   5.70                    0.1
maintenance dose, [mg/kg] [ml;g/animal]                11.13   5.56

drugs in all, ml or g                                  33.53
expenses, kr.                                           0.00
                                                                                       0.0


                                            CONCENTRATIONS
maximum plasma concentration, mg/l                      0.08
minimum plasma concentration, mg/l                      0.06
maximum tissue concentration, mg/l                      0.40
minimum tissue concentration, mg/l                      0.31
drugs ml or g per animal                               33.53

recommended dose, mg/kg                                10.00
withdrawal time slaughter, 24 hours                    30.00
prolongation of withdrawal time from plasma, hours      0.36


t1/2el, hours                                           1.89
t1/2ab, hours                                           1.88
F/V                                                     0.06
F, %
1   1   2      2   3             3

                       Plasma
                       Tissue
                       MIC
                       Plasmai
                       Tissuei




        Days
                                 Time        n       Hours
Cmic               0.02
ka                 0.37                  1       1            1
ke                 0.37                  2       1            2
                                         4       1            4
aT                 0.01                  6       1            6
eT                 0.01                 12       1           12
tmax               5.84                  1       2           13
etmax              0.12                  2       2           14
Cmin               0.01                  4       2           16
Dv                 2.50                  6       2           18
Cmax               0.02                 12       2           24
Dp                 2.56                  1       3           25
cmaxcmic           0.90                  2       3           26
DpFakt            11.41                  4       3           28
DvFakt            11.13                  6       3           30
CmaxFakt           0.08                 12       3           36
CminFakt           0.06                  1       4           37
faktor,MIC         4.00                  2       4           38
                                         4       4           40
                                         6       4           42
Dpkorrekt         11.41                 12       4           48
                                         1       5           49
Dvkorrekt         11.13                  2       5           50
                                         4       5           52
Cmaxkorrekt        0.08                  6       5           54
Cminkorrekt        0.06                 12       5           60


medicin dyr       33.53
medicin i alt     33.53
pris               0.00




    Time      Stomac Duodenum   Jejunum_1 Jejunum_2 Ileum
    days       ug/g
        0.25    756.868  21.368 143.256      358.77  75.842
          0.5     11.56    8.62     12.41    157.06    28.91
            1     2.561   5.533     2.772     5.729    4.514
          1.5    0.2473  1.1572    0.9329    1.3344  2.7235
            2    2.3668  3.0654    3.0109    4.6475  2.4363
            3     0.182  1.0628    1.0638     1.411  1.7622
            4    0.4717  0.7534 0.91777 1.73876      1.7004
            6   0.06122 0.39987 0.54112      0.4793 0.58301
Zn dosis, ppm      2500
Foder/gang, kg        0.35
vægt, kg                10
Zn dosis, mg/kg        875


Oxytertracyclin                      Jejunum
Dosis         mg/kg          11.13    4.56334
                                      1.99771
                                      0.07287
                                      0.01697
                                      0.05911
                                      0.01795
                                      0.02212
                                        0.0061
kaFVD/ka-ke enkeT          enketi      ekeT          enkaT      ekati          ekaT          Plasma     Tissue

      84.64         0.01        0.69          0.01       0.01           0.69          0.01       0.17       0.86
      84.64         0.01        0.48          0.01       0.01           0.48          0.01       0.24       1.18
      84.64         0.01        0.23          0.01       0.01           0.23          0.01       0.23       1.14
      84.64         0.01        0.11          0.01       0.01           0.11          0.01       0.16       0.82
      84.64         0.01        0.01          0.01       0.01           0.01          0.01       0.04       0.18
      84.64         0.00        0.69          0.01       0.00           0.69          0.01       0.20       0.99
      84.64         0.00        0.48          0.01       0.00           0.48          0.01       0.26       1.29
      84.64         0.00        0.23          0.01       0.00           0.23          0.01       0.24       1.19
      84.64         0.00        0.11          0.01       0.00           0.11          0.01       0.17       0.85
      84.64         0.00        0.01          0.01       0.00           0.01          0.01       0.04       0.19
      84.64         0.00        0.69          0.01       0.00           0.69          0.01       0.20       0.99
      84.64         0.00        0.48          0.01       0.00           0.48          0.01       0.26       1.29
      84.64         0.00        0.23          0.01       0.00           0.23          0.01       0.24       1.19
      84.64         0.00        0.11          0.01       0.00           0.11          0.01       0.17       0.85
      84.64         0.00        0.01          0.01       0.00           0.01          0.01       0.04       0.19
      84.64         0.00        0.69          0.01       0.00           0.69          0.01       0.20       0.99
      84.64         0.00        0.48          0.01       0.00           0.48          0.01       0.26       1.29
      84.64         0.00        0.23          0.01       0.00           0.23          0.01       0.24       1.19
      84.64         0.00        0.11          0.01       0.00           0.11          0.01       0.17       0.85
      84.64         0.00        0.01          0.01       0.00           0.01          0.01       0.04       0.19
      84.64         0.00        0.69          0.01       0.00           0.69          0.01       0.20       0.99
      84.64         0.00        0.48          0.01       0.00           0.48          0.01       0.26       1.29
      84.64         0.00        0.23          0.01       0.00           0.23          0.01       0.24       1.19
      84.64         0.00        0.11          0.01       0.00           0.11          0.01       0.17       0.85
      84.64         0.00        0.01          0.01       0.00           0.01          0.01       0.04       0.19




   Colon      Caecum

   171.044     604.646
   1135.32
   436.503      78.708
   43.8104      9.7317
   87.8152     19.9664
    2.9722      1.8359
    2.8816     1.83835
   0.47058     0.26127
Colon         Days          MIC
 2.17557639          0.25      32.00
 14.4405848           0.5      32.00
 5.55205457             1      32.00
 0.55724183           1.5      32.00
 1.11695632             2      32.00
 0.03780459             3      32.00
 0.03665221             4      32.00
 0.00598549             6      32.00
MIC          Days          Plasmai    Tissuei

      0.10          0.04       0.18        0.88
      0.10          0.08       0.24        1.21
      0.10          0.17       0.23        1.17
      0.10          0.25       0.17        0.84
      0.10          0.50       0.04        0.19
      0.10          0.54
      0.10          0.58
      0.10          0.67
      0.10          0.75
      0.10          1.00
      0.10          1.04
      0.10          1.08
      0.10          1.17
      0.10          1.25
      0.10          1.50
      0.10          1.54
      0.10          1.58
      0.10          1.67
      0.10          1.75
      0.10          2.00
      0.10          2.04
      0.10          2.08
      0.10          2.17
      0.10          2.25
      0.10          2.50
Reference: Laber G and Schütze E, 1981

Tylosin, PO                                 TYPE IN
MIC extracellular, relevant for Lawsonia               16.00
MIC, µg/ml                                              0.02                                 0
postantibiotic time, hours                              2.40                           1.0
dosing interval, hours                                 12.00
tissue/plasma ratio                                     1.00

weight of animal, kg                                   50.00
number of animals                                       1.00
treatment period, 24 hours                              3.00




                                                                      Conc. (mcg/ml)
drug concentration, mg/ml or mg/g                     100.00
product price, kr./ml or g                              0.00                           0.1

                                            RESULTS
initial dose, [mg/kg] [ml or g/animal]                  5.79   2.89
maintenance dose, [mg/kg] [ml;g/animal]                 5.66   2.83

drugs in all, ml or g                                  17.05
expenses, kr.                                           0.00
                                                                                       0.0


                                            CONCENTRATIONS
maximum plasma concentration, mg/l                      0.08
minimum plasma concentration, mg/l                      0.02
maximum tissue concentration, mg/l                      0.08                                 0
minimum tissue concentration, mg/l                      0.02          100.0
drugs ml or g per animal                               17.05

recommended dose, mg/kg                                10.00
                                                                              10.0
withdrawal time slaughter, 24 hours                     1.00
prolongation of withdrawal time from plasma, hours     -1.49

                                                                                       1.0
                                                                      Conc. (mcg/ml)




t1/2el, hours                                           1.89
t1/2ab, hours                                           1.80
F/V                                                     0.06                           0.1
F, %

                                                                                       0.0


                                                                                       0.0
    1       1       2          2       3                 3

                                               Plasma
                                               Tissue
                                               MIC
                                               Plasmai
                                               Tissuei




                    Days



1       2       3          4       5       6             7


                                           Jenunum

                                           Colon

                                           MIC




                    Days
                                  Time        n         Hours
Cmic                0.02
ka                  0.39                  1         1            1
ke                  0.37                  2         1            2
                                          4         1            4
aT                  0.01                  6         1            6
eT                  0.01                 12         1           12
tmax                4.00                  1         2           13
etmax               0.23                  2         2           14
Cmin                0.01                  4         2           16
Dv                  2.64                  6         2           18
Cmax                0.04                 12         2           24
Dp                  2.70                  1         3           25
cmaxcmic            1.86                  2         3           26
DpFakt              5.79                  4         3           28
DvFakt              5.66                  6         3           30
CmaxFakt            0.08                 12         3           36
CminFakt            0.02                  1         4           37
faktor,MIC          4.00                  2         4           38
                                          4         4           40
                                          6         4           42
Dpkorrekt           5.79                 12         4           48
                                          1         5           49
Dvkorrekt           5.66                  2         5           50
                                          4         5           52
Cmaxkorrekt         0.08                  6         5           54
Cminkorrekt         0.02                 12         5           60


medicin dyr        17.05
medicin i alt      17.05
pris                0.00




    Time        Stomac Duodenum    Jejunum_1 Jejunum_2 Ileum
    days         ug/g
        0.25      756.868  21.368 143.256       358.77  75.842
          0.5        11.56    8.62     12.41    157.06    28.91
            1        2.561   5.533     2.772     5.729    4.514
          1.5      0.2473  1.1572     0.9329    1.3344  2.7235
            2      2.3668  3.0654     3.0109    4.6475  2.4363
            3        0.182 1.0628     1.0638     1.411  1.7622
            4      0.4717  0.7534 0.91777 1.73876       1.7004
            6     0.06122 0.39987 0.54112       0.4793 0.58301
Zn dosis, ppm        2500
Foder/gang, kg        0.35
vægt, kg                10
Zn dosis, mg/kg        875
Tylosin                  Jejunum
Dosis     mg/kg   5.66    2.32138
                          1.01624
                          0.03707
                          0.00863
                          0.03007
                          0.00913
                          0.01125
                            0.0031
kaFVD/ka-ke enkeT          enketi      ekeT          enkaT      ekati          ekaT          Plasma     Tissue

       6.80         0.01        0.69          0.01       0.01           0.68          0.01       0.09       0.09
       6.80         0.01        0.48          0.01       0.01           0.46          0.01       0.12       0.12
       6.80         0.01        0.23          0.01       0.01           0.21          0.01       0.12       0.12
       6.80         0.01        0.11          0.01       0.01           0.10          0.01       0.08       0.08
       6.80         0.01        0.01          0.01       0.01           0.01          0.01       0.02       0.02
       6.80         0.00        0.69          0.01       0.00           0.68          0.01       0.10       0.10
       6.80         0.00        0.48          0.01       0.00           0.46          0.01       0.13       0.13
       6.80         0.00        0.23          0.01       0.00           0.21          0.01       0.12       0.12
       6.80         0.00        0.11          0.01       0.00           0.10          0.01       0.09       0.09
       6.80         0.00        0.01          0.01       0.00           0.01          0.01       0.02       0.02
       6.80         0.00        0.69          0.01       0.00           0.68          0.01       0.10       0.10
       6.80         0.00        0.48          0.01       0.00           0.46          0.01       0.13       0.13
       6.80         0.00        0.23          0.01       0.00           0.21          0.01       0.12       0.12
       6.80         0.00        0.11          0.01       0.00           0.10          0.01       0.09       0.09
       6.80         0.00        0.01          0.01       0.00           0.01          0.01       0.02       0.02
       6.80         0.00        0.69          0.01       0.00           0.68          0.01       0.10       0.10
       6.80         0.00        0.48          0.01       0.00           0.46          0.01       0.13       0.13
       6.80         0.00        0.23          0.01       0.00           0.21          0.01       0.12       0.12
       6.80         0.00        0.11          0.01       0.00           0.10          0.01       0.09       0.09
       6.80         0.00        0.01          0.01       0.00           0.01          0.01       0.02       0.02
       6.80         0.00        0.69          0.01       0.00           0.68          0.01       0.10       0.10
       6.80         0.00        0.48          0.01       0.00           0.46          0.01       0.13       0.13
       6.80         0.00        0.23          0.01       0.00           0.21          0.01       0.12       0.12
       6.80         0.00        0.11          0.01       0.00           0.10          0.01       0.09       0.09
       6.80         0.00        0.01          0.01       0.00           0.01          0.01       0.02       0.02




   Colon      Caecum

   171.044     604.646
   1135.32
   436.503      78.708
   43.8104      9.7317
   87.8152     19.9664
    2.9722      1.8359
    2.8816     1.83835
   0.47058     0.26127
Colon         Days          MIC
  1.1067183          0.25         16.00
 7.34594271           0.5         16.00
 2.82433678             1         16.00
 0.28346958           1.5         16.00
 0.56819701             2         16.00
 0.01923124             3         16.00
 0.01864502             4         16.00
 0.00304483             6         16.00
MIC          Days          Plasmai    Tissuei

      0.02          0.04       0.09        0.09
      0.02          0.08       0.13        0.13
      0.02          0.17       0.12        0.12
      0.02          0.25       0.08        0.08
      0.02          0.50       0.02        0.02
      0.02          0.54
      0.02          0.58
      0.02          0.67
      0.02          0.75
      0.02          1.00
      0.02          1.04
      0.02          1.08
      0.02          1.17
      0.02          1.25
      0.02          1.50
      0.02          1.54
      0.02          1.58
      0.02          1.67
      0.02          1.75
      0.02          2.00
      0.02          2.04
      0.02          2.08
      0.02          2.17
      0.02          2.25
      0.02          2.50
NO DATA PHARMAKOKINETIC DATA AVAILABLE

Tylvalosin, PO                             TYPE IN
MIC extracellular, relevant for Lawsonia
MIC, µg/ml                                                                                            0
postantibiotic time, hours                                    2.40                     10.0
dosing interval, hours                                       12.00
tissue/plasma ratio                                           0.80

weight of animal, kg                                      50.00
number of animals                                          1.00
treatment period, 24 hours                                 3.00




                                                                               Conc. (mcg/ml)
drug concentration, mg/ml or mg/g                        100.00
product price, kr./ml or g                                 0.00

                                           RESULTS
initial dose, [mg/kg] [ml or g/animal]         #VALUE!               #VALUE!
maintenance dose, [mg/kg] [ml;g/animal]        #VALUE!               #VALUE!

drugs in all, ml or g                            #VALUE!
expenses, kr.                                    #VALUE!
                                                                                                1.0


                                           CONCENTRATIONS
maximum plasma concentration, mg/l             #VALUE!
minimum plasma concentration, mg/l             #VALUE!
maximum tissue concentration, mg/l             #VALUE!                                                0
minimum tissue concentration, mg/l             #VALUE!                                 10.0
drugs ml or g per animal                       #VALUE!

recommended dose, mg/kg
withdrawal time slaughter, 24 hours
prolongation of withdrawal time from plasma, hours #VALUE!
                                                                               Conc. (mcg/ml)




t1/2el, hours                              NO DATA
t1/2ab, hours                              NO DATA
F/V                                        NO DATA
F, %
V, L/kg




                                                                                                1.0



a) relevant for Lawsonia
    1       1       2          2       3                 3

                                               Plasma
                                               Tissue
                                               MIC
                                               Plasmai
                                               Tissuei




                    Days



1       2       3          4       5       6             7


                                           Jenunum

                                           Colon

                                           MIC




                    Days
                                  Time        n         Hours
Cmic                 0.00
ka              #VALUE!                   1         1            1
ke              #VALUE!                   2         1            2
                                          4         1            4
aT              #VALUE!                   6         1            6
eT              #VALUE!                  12         1           12
tmax            #VALUE!                   1         2           13
etmax           #VALUE!                   2         2           14
Cmin            #VALUE!                   4         2           16
Dv              #VALUE!                   6         2           18
Cmax            #VALUE!                  12         2           24
Dp              #VALUE!                   1         3           25
cmaxcmic        #VALUE!                   2         3           26
DpFakt          #VALUE!                   4         3           28
DvFakt          #VALUE!                   6         3           30
CmaxFakt        #VALUE!                  12         3           36
CminFakt        #VALUE!                   1         4           37
faktor,MIC           4.00                 2         4           38
                                          4         4           40
                                          6         4           42
Dpkorrekt       #VALUE!                  12         4           48
                                          1         5           49
Dvkorrekt       #VALUE!                   2         5           50
                                          4         5           52
Cmaxkorrekt     #VALUE!                   6         5           54
Cminkorrekt     #VALUE!                  12         5           60


medicin dyr     #VALUE!
medicin i alt   #VALUE!
pris            #VALUE!




    Time        Stomac Duodenum    Jejunum_1 Jejunum_2 Ileum
    days         ug/g
        0.25      756.868  21.368 143.256       358.77  75.842
          0.5        11.56    8.62     12.41    157.06    28.91
            1        2.561   5.533     2.772     5.729    4.514
          1.5      0.2473  1.1572     0.9329    1.3344  2.7235
            2      2.3668  3.0654     3.0109    4.6475  2.4363
            3        0.182 1.0628     1.0638     1.411  1.7622
            4      0.4717  0.7534 0.91777 1.73876       1.7004
            6     0.06122 0.39987 0.54112       0.4793 0.58301
Zn dosis, ppm        2500
Foder/gang, kg        0.35
vægt, kg                10
Zn dosis, mg/kg        875
Oxytertracyclin                 Jejunum
Dosis         mg/kg   #VALUE!   #VALUE!
                                #VALUE!
                                #VALUE!
                                #VALUE!
                                #VALUE!
                                #VALUE!
                                #VALUE!
                                #VALUE!
kaFVD/ka-ke enkeT       enketi    ekeT      enkaT     ekati     ekaT      Plasma    Tissue

 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!




   Colon     Caecum

   171.044    604.646
   1135.32
   436.503     78.708
   43.8104     9.7317
   87.8152    19.9664
    2.9722     1.8359
    2.8816    1.83835
   0.47058    0.26127
Colon      Days          MIC
 #VALUE!          0.25         0.00
 #VALUE!           0.5         0.00
 #VALUE!             1         0.00
 #VALUE!           1.5         0.00
 #VALUE!             2         0.00
 #VALUE!             3         0.00
 #VALUE!             4         0.00
 #VALUE!             6         0.00
MIC          Days          Plasmai   Tissuei

      0.00          0.04   #VALUE!   #VALUE!
      0.00          0.08   #VALUE!   #VALUE!
      0.00          0.17   #VALUE!   #VALUE!
      0.00          0.25   #VALUE!   #VALUE!
      0.00          0.50   #VALUE!   #VALUE!
      0.00          0.54
      0.00          0.58
      0.00          0.67
      0.00          0.75
      0.00          1.00
      0.00          1.04
      0.00          1.08
      0.00          1.17
      0.00          1.25
      0.00          1.50
      0.00          1.54
      0.00          1.58
      0.00          1.67
      0.00          1.75
      0.00          2.00
      0.00          2.04
      0.00          2.08
      0.00          2.17
      0.00          2.25
      0.00          2.50
Reference: Shen J et al. AJVR 66, 1071, 2005

Tilmicosin, PO                              TYPE IN

MIC, µg/ml                                              3.00                                 0
postantibiotic time, hours                              2.40          100.0
dosing interval, hours                                 12.00
tissue/plasma ratio                                     6.00

weight of animal, kg                                   50.00
number of animals                                       1.00
                                                                              10.0
treatment period, 24 hours                              3.00




                                                                      Conc. (mcg/ml)
drug concentration, mg/ml or mg/g                     100.00
product price, kr./ml or g                              0.00

                                            RESULTS
initial dose, [mg/kg] [ml or g/animal]                 19.97   9.99                    1.0
maintenance dose, [mg/kg] [ml;g/animal]                17.52   8.76

drugs in all, ml or g                                  53.79
expenses, kr.                                           0.00
                                                                                       0.1


                                            CONCENTRATIONS
maximum plasma concentration, mg/l                      2.00
minimum plasma concentration, mg/l                      0.58
maximum tissue concentration, mg/l                     12.00
minimum tissue concentration, mg/l                      3.50
drugs ml or g per animal                               53.79

recommended dose, mg/kg                                20.00
withdrawal time slaughter, 24 hours                    21.00
prolongation of withdrawal time from plasma, hours     -0.01


t1/2el, hours                                           3.85
t1/2ab, hours                                           1.73
F/V                                                     0.15
F, %                                                    0.00
V, L/kg                                     #1334




a) relevant for Lawsonia
1   1   2      2   3             3

                       Plasma
                       Tissue
                       MIC
                       Plasmai
                       Tissuei




        Days
                                 Time        n       Hours
Cmic               0.50
ka                 0.40                  1       1            1
ke                 0.18                  2       1            2
                                         4       1            4
aT                 0.01                  6       1            6
eT                 0.12                 12       1           12
tmax               2.20                  1       2           13
etmax              0.67                  2       2           14
Cmin               0.32                  4       2           16
Dv                 9.75                  6       2           18
Cmax               1.11                 12       2           24
Dp                11.11                  1       3           25
cmaxcmic           2.23                  2       3           26
DpFakt            19.97                  4       3           28
DvFakt            17.52                  6       3           30
CmaxFakt           2.00                 12       3           36
CminFakt           0.58                  1       4           37
faktor,MIC         4.00                  2       4           38
                                         4       4           40
                                         6       4           42
Dpkorrekt         19.97                 12       4           48
                                         1       5           49
Dvkorrekt         17.52                  2       5           50
                                         4       5           52
Cmaxkorrekt        2.00                  6       5           54
Cminkorrekt        0.58                 12       5           60


medicin dyr       53.79
medicin i alt     53.79
pris               0.00




    Time      Stomac Duodenum   Jejunum_1 Jejunum_2 Ileum
    days       ug/g
        0.25    756.868  21.368 143.256      358.77  75.842
          0.5     11.56    8.62     12.41    157.06    28.91
            1     2.561   5.533     2.772     5.729    4.514
          1.5    0.2473  1.1572    0.9329    1.3344  2.7235
            2    2.3668  3.0654    3.0109    4.6475  2.4363
            3     0.182  1.0628    1.0638     1.411  1.7622
            4    0.4717  0.7534 0.91777 1.73876      1.7004
            6   0.06122 0.39987 0.54112      0.4793 0.58301
Zn dosis, ppm      2500
Foder/gang, kg        0.35
vægt, kg                10
Zn dosis, mg/kg        875


Oxytertracyclin                      Jejunum
Dosis         mg/kg          17.52    7.18428
                                      3.14509
                                      0.11472
                                      0.02672
                                      0.09307
                                      0.02825
                                      0.03482
                                        0.0096
kaFVD/ka-ke enkeT          enketi      ekeT          enkaT      ekati          ekaT          Plasma     Tissue

       4.78         0.12        0.84          0.12       0.01           0.67          0.01       0.79       4.73
       4.78         0.12        0.70          0.12       0.01           0.45          0.01       1.19       7.12
       4.78         0.12        0.49          0.12       0.01           0.20          0.01       1.36       8.17
       4.78         0.12        0.34          0.12       0.01           0.09          0.01       1.19       7.14
       4.78         0.12        0.12          0.12       0.01           0.01          0.01       0.51       3.07
       4.78         0.01        0.84          0.12       0.00           0.67          0.01       1.22       7.33
       4.78         0.01        0.70          0.12       0.00           0.45          0.01       1.55       9.32
       4.78         0.01        0.49          0.12       0.00           0.20          0.01       1.62       9.73
       4.78         0.01        0.34          0.12       0.00           0.09          0.01       1.37       8.24
       4.78         0.01        0.12          0.12       0.00           0.01          0.01       0.58       3.45
       4.78         0.00        0.84          0.12       0.00           0.67          0.01       1.28       7.65
       4.78         0.00        0.70          0.12       0.00           0.45          0.01       1.60       9.59
       4.78         0.00        0.49          0.12       0.00           0.20          0.01       1.65       9.91
       4.78         0.00        0.34          0.12       0.00           0.09          0.01       1.39       8.37
       4.78         0.00        0.12          0.12       0.00           0.01          0.01       0.58       3.49
       4.78         0.00        0.84          0.12       0.00           0.67          0.01       1.28       7.69
       4.78         0.00        0.70          0.12       0.00           0.45          0.01       1.60       9.62
       4.78         0.00        0.49          0.12       0.00           0.20          0.01       1.66       9.94
       4.78         0.00        0.34          0.12       0.00           0.09          0.01       1.40       8.38
       4.78         0.00        0.12          0.12       0.00           0.01          0.01       0.58       3.50
       4.78         0.00        0.84          0.12       0.00           0.67          0.01       1.28       7.69
       4.78         0.00        0.70          0.12       0.00           0.45          0.01       1.60       9.62
       4.78         0.00        0.49          0.12       0.00           0.20          0.01       1.66       9.94
       4.78         0.00        0.34          0.12       0.00           0.09          0.01       1.40       8.38
       4.78         0.00        0.12          0.12       0.00           0.01          0.01       0.58       3.50




   Colon      Caecum

   171.044     604.646
   1135.32
   436.503      78.708
   43.8104      9.7317
   87.8152     19.9664
    2.9722      1.8359
    2.8816     1.83835
   0.47058     0.26127
Colon         Days          MIC
 3.42511344          0.25         0.00
 22.7344998           0.5         0.00
 8.74086369             1         0.00
 0.87729233           1.5         0.00
 1.75847748             2         0.00
 0.05951756             3         0.00
 0.05770332             4         0.00
 0.00942325             6         0.00
MIC          Days          Plasmai    Tissuei

      3.00          0.04       0.90        5.39
      3.00          0.08       1.35        8.12
      3.00          0.17       1.55        9.31
      3.00          0.25       1.36        8.13
      3.00          0.50       0.58        3.50
      3.00          0.54
      3.00          0.58
      3.00          0.67
      3.00          0.75
      3.00          1.00
      3.00          1.04
      3.00          1.08
      3.00          1.17
      3.00          1.25
      3.00          1.50
      3.00          1.54
      3.00          1.58
      3.00          1.67
      3.00          1.75
      3.00          2.00
      3.00          2.04
      3.00          2.08
      3.00          2.17
      3.00          2.25
      3.00          2.50
Reference:

Tulathromycin, IM                           TYPE IN

MIC, µg/ml                                              3.50                                 0
postantibiotic time, hours                              0.00                  10.0
dosing interval, hours                                 72.00
tissue/plasma ratio                                    51.00

weight of animal, kg                                   50.00
number of animals                                       1.00
treatment period, 24 hours                              3.00                           1.0




                                                                      Conc. (mcg/ml)
drug concentration, mg/ml or mg/g                     100.00
product price, kr./ml or g                              0.00

                                            RESULTS
initial dose, [mg/kg] [ml or g/animal]                  2.54   1.27                    0.1
maintenance dose, [mg/kg] [ml;g/animal]                 1.55   0.78

drugs in all, ml or g                                   1.27
expenses, kr.                                           0.00
                                                                                       0.0


                                            CONCENTRATIONS
maximum plasma concentration, mg/l                      0.15
minimum plasma concentration, mg/l                      0.07
maximum tissue concentration, mg/l                      7.77
minimum tissue concentration, mg/l                      3.50
drugs ml or g per animal                                1.27

recommended dose, mg/kg                                 2.50
withdrawal time slaughter, 24 hours                    33.00
prolongation of withdrawal time from plasma, hours      1.24


t1/2el, hours                                          52.98
t1/2ab, hours                                           4.70
F/V                                                     0.06
F, %
2   4   6   8      10   12   14         16

                              Plasma
                              Tissue
                              MIC
                              Plasmai
                              Tissuei




            Days
                                 Time        n       Hours
Cmic               0.07
ka                 0.15                  6       1         6
ke                 0.01                 12       1        12
                                        24       1        24
aT                 0.00                 36       1        36
eT                 0.39                 72       1        72
tmax               3.94                  6       2        78
etmax              0.95                 12       2        84
Cmin               0.07                 24       2        96
Dv                 1.55                 36       2       108
Cmax               0.15                 72       2       144
Dp                 2.54                  6       3       150
cmaxcmic           2.22                 12       3       156
DpFakt             2.29                 24       3       168
DvFakt             1.40                 36       3       180
CmaxFakt           0.14                 72       3       216
CminFakt           0.06                  6       4       222
faktor,MIC         2.00                 12       4       228
                                        24       4       240
                                        36       4       252
Dpkorrekt          2.54                 72       4       288
                                         6       5       294
Dvkorrekt          1.55                 12       5       300
                                        24       5       312
Cmaxkorrekt        0.15                 36       5       324
Cminkorrekt        0.07                 72       5       360


medicin dyr        1.27
medicin i alt      1.27
pris               0.00




    Time      Stomac Duodenum   Jejunum_1 Jejunum_2 Ileum
    days       ug/g
        0.25    756.868  21.368 143.256      358.77  75.842
          0.5     11.56    8.62     12.41    157.06    28.91
            1     2.561   5.533     2.772     5.729    4.514
          1.5    0.2473  1.1572    0.9329    1.3344  2.7235
            2    2.3668  3.0654    3.0109    4.6475  2.4363
            3     0.182  1.0628    1.0638     1.411  1.7622
            4    0.4717  0.7534 0.91777 1.73876      1.7004
            6   0.06122 0.39987 0.54112      0.4793 0.58301
Zn dosis, ppm      2500
Foder/gang, kg        0.35
vægt, kg                10
Zn dosis, mg/kg        875


Oxytertracyclin                     Jejunum
Dosis         mg/kg          1.55    0.63558
                                     0.27824
                                     0.01015
                                     0.00236
                                     0.00823
                                       0.0025
                                     0.00308
                                     0.00085
kaFVD/ka-ke enkeT          enketi      ekeT          enkaT      ekati          ekaT          Plasma     Tissue

       0.11         0.39        0.92          0.39       0.00           0.41          0.00       0.05       2.80
       0.11         0.39        0.85          0.39       0.00           0.17          0.00       0.07       3.75
       0.11         0.39        0.73          0.39       0.00           0.03          0.00       0.08       3.84
       0.11         0.39        0.62          0.39       0.00           0.00          0.00       0.07       3.39
       0.11         0.39        0.39          0.39       0.00           0.00          0.00       0.04       2.14
       0.11         0.15        0.92          0.39       0.00           0.41          0.00       0.09       4.78
       0.11         0.15        0.85          0.39       0.00           0.17          0.00       0.11       5.57
       0.11         0.15        0.73          0.39       0.00           0.03          0.00       0.11       5.40
       0.11         0.15        0.62          0.39       0.00           0.00          0.00       0.09       4.73
       0.11         0.15        0.39          0.39       0.00           0.00          0.00       0.06       2.97
       0.11         0.06        0.92          0.39       0.00           0.41          0.00       0.11       5.55
       0.11         0.06        0.85          0.39       0.00           0.17          0.00       0.12       6.28
       0.11         0.06        0.73          0.39       0.00           0.03          0.00       0.12       6.01
       0.11         0.06        0.62          0.39       0.00           0.00          0.00       0.10       5.25
       0.11         0.06        0.39          0.39       0.00           0.00          0.00       0.06       3.29
       0.11         0.02        0.92          0.39       0.00           0.41          0.00       0.11       5.85
       0.11         0.02        0.85          0.39       0.00           0.17          0.00       0.13       6.56
       0.11         0.02        0.73          0.39       0.00           0.03          0.00       0.12       6.25
       0.11         0.02        0.62          0.39       0.00           0.00          0.00       0.11       5.45
       0.11         0.02        0.39          0.39       0.00           0.00          0.00       0.07       3.42
       0.11         0.01        0.92          0.39       0.00           0.41          0.00       0.12       5.96
       0.11         0.01        0.85          0.39       0.00           0.17          0.00       0.13       6.67
       0.11         0.01        0.73          0.39       0.00           0.03          0.00       0.12       6.34
       0.11         0.01        0.62          0.39       0.00           0.00          0.00       0.11       5.53
       0.11         0.01        0.39          0.39       0.00           0.00          0.00       0.07       3.47




   Colon      Caecum

   171.044     604.646
   1135.32
   436.503      78.708
   43.8104      9.7317
   87.8152     19.9664
    2.9722      1.8359
    2.8816     1.83835
   0.47058     0.26127
Colon         Days          MIC
 0.30301466          0.25         0.00
 2.01128717           0.5         0.00
 0.77329113             1         0.00
 0.07761274           1.5         0.00
 0.15556987             2         0.00
 0.00526543             3         0.00
 0.00510493             4         0.00
 0.00083366             6         0.00
MIC          Days       Plasmai    Tissuei

      3.50       0.25       0.09        4.59
      3.50       0.50       0.12        6.14
      3.50       1.00       0.12        6.30
      3.50       1.50       0.11        5.56
      3.50       3.00       0.07        3.50
      3.50       3.25
      3.50       3.50
      3.50       4.00
      3.50       4.50
      3.50       6.00
      3.50       6.25
      3.50       6.50
      3.50       7.00
      3.50       7.50
      3.50       9.00
      3.50       9.25
      3.50       9.50
      3.50      10.00
      3.50      10.50
      3.50      12.00
      3.50      12.25
      3.50      12.50
      3.50      13.00
      3.50      13.50
      3.50      15.00
Reference:
NO DATA PHARMAKOKINETIC DATA AVAILABLE
Lincomycin, IM                  TYPE IN

MIC, µg/ml                                                  0.25                                    0
postantibiotic time, hours                                  2.40                              1.0
dosing interval, hours                                     12.00
tissue/plasma ratio                                         1.00

weight of animal, kg                                      50.00
number of animals                                          1.00
treatment period, 24 hours                                 3.00




                                                                             Conc. (mcg/ml)
drug concentration, mg/ml or mg/g                        100.00
product price, kr./ml or g                                 0.00

                                           RESULTS
initial dose, [mg/kg] [ml or g/animal]         #VALUE!             #VALUE!
maintenance dose, [mg/kg] [ml;g/animal]        #VALUE!             #VALUE!

drugs in all, ml or g                            #VALUE!
expenses, kr.                                    #VALUE!
                                                                                              0.1


                                           CONCENTRATIONS
maximum plasma concentration, mg/l             #VALUE!
minimum plasma concentration, mg/l             #VALUE!
maximum tissue concentration, mg/l             #VALUE!
minimum tissue concentration, mg/l             #VALUE!
drugs ml or g per animal                       #VALUE!

recommended dose, mg/kg                                    10.00
withdrawal time slaughter, 24 hours                         6.00
prolongation of withdrawal time from plasma, hours #VALUE!


t1/2el, hours                              NO DATA
t1/2ab, hours                              NO DATA
F/V                                        NO DATA
F, %
V, L/kg
1   1   2      2   3             3

                       Plasma
                       Tissue
                       MIC
                       Plasmai
                       Tissuei




        Days
                                  Time        n         Hours
Cmic                 0.25
ka              #VALUE!                   1         1            1
ke              #VALUE!                   2         1            2
                                          4         1            4
aT              #VALUE!                   6         1            6
eT              #VALUE!                  12         1           12
tmax            #VALUE!                   1         2           13
etmax           #VALUE!                   2         2           14
Cmin            #VALUE!                   4         2           16
Dv              #VALUE!                   6         2           18
Cmax            #VALUE!                  12         2           24
Dp              #VALUE!                   1         3           25
cmaxcmic        #VALUE!                   2         3           26
DpFakt          #VALUE!                   4         3           28
DvFakt          #VALUE!                   6         3           30
CmaxFakt        #VALUE!                  12         3           36
CminFakt        #VALUE!                   1         4           37
faktor,MIC           4.00                 2         4           38
                                          4         4           40
                                          6         4           42
Dpkorrekt       #VALUE!                  12         4           48
                                          1         5           49
Dvkorrekt       #VALUE!                   2         5           50
                                          4         5           52
Cmaxkorrekt     #VALUE!                   6         5           54
Cminkorrekt     #VALUE!                  12         5           60


medicin dyr     #VALUE!
medicin i alt   #VALUE!
pris            #VALUE!




    Time        Stomac Duodenum    Jejunum_1 Jejunum_2 Ileum
    days         ug/g
        0.25      756.868  21.368 143.256       358.77  75.842
          0.5        11.56    8.62     12.41    157.06    28.91
            1        2.561   5.533     2.772     5.729    4.514
          1.5      0.2473  1.1572     0.9329    1.3344  2.7235
            2      2.3668  3.0654     3.0109    4.6475  2.4363
            3        0.182 1.0628     1.0638     1.411  1.7622
            4      0.4717  0.7534 0.91777 1.73876       1.7004
            6     0.06122 0.39987 0.54112       0.4793 0.58301
Zn dosis, ppm        2500
Foder/gang, kg        0.35
vægt, kg                10
Zn dosis, mg/kg        875
Lincosamin                     Jejunum
Dosis        mg/kg   #VALUE!   #VALUE!
                               #VALUE!
                               #VALUE!
                               #VALUE!
                               #VALUE!
                               #VALUE!
                               #VALUE!
                               #VALUE!
kaFVD/ka-ke enkeT       enketi    ekeT      enkaT     ekati     ekaT      Plasma    Tissue

 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!




   Colon     Caecum

   171.044    604.646
   1135.32
   436.503     78.708
   43.8104     9.7317
   87.8152    19.9664
    2.9722     1.8359
    2.8816    1.83835
   0.47058    0.26127
Colon      Days          MIC
 #VALUE!          0.25         0.00
 #VALUE!           0.5         0.00
 #VALUE!             1         0.00
 #VALUE!           1.5         0.00
 #VALUE!             2         0.00
 #VALUE!             3         0.00
 #VALUE!             4         0.00
 #VALUE!             6         0.00
MIC          Days          Plasmai   Tissuei

      0.25          0.04   #VALUE!   #VALUE!
      0.25          0.08   #VALUE!   #VALUE!
      0.25          0.17   #VALUE!   #VALUE!
      0.25          0.25   #VALUE!   #VALUE!
      0.25          0.50   #VALUE!   #VALUE!
      0.25          0.54
      0.25          0.58
      0.25          0.67
      0.25          0.75
      0.25          1.00
      0.25          1.04
      0.25          1.08
      0.25          1.17
      0.25          1.25
      0.25          1.50
      0.25          1.54
      0.25          1.58
      0.25          1.67
      0.25          1.75
      0.25          2.00
      0.25          2.04
      0.25          2.08
      0.25          2.17
      0.25          2.25
      0.25          2.50
Reference: Nielsen P, Gyrd-Hansen, N: J.vet.Pharmacol.Therap.

Lincomycin, PO                              TYPE IN
MIC extracellular, relevant for Lawsonia                 32.00
MIC, µg/ml                                                0.25
postantibiotic time, hours                                2.40
dosing interval, hours                                   12.00
tissue/plasma ratio                                       1.50
                                                                                                   10.0

weight of animal, kg                                    50.00
number of animals                                        1.00
treatment period, 24 hours                               3.00




                                                                        Conc. (mcg/ml)
drug concentration, mg/ml or mg/g                      100.00
product price, kr./ml or g                               0.00
                                                                                                    1.0
                                            RESULTS
initial dose, [mg/kg] [ml or g/animal]                    7.38   3.69
maintenance dose, [mg/kg] [ml;g/animal]                   6.70   3.35

drugs in all, ml or g                                    20.44
expenses, kr.                                             0.00


                                                                                                    0.1
                                            CONCENTRATIONS
maximum plasma concentration, mg/l                      0.67
minimum plasma concentration, mg/l                      1.03
maximum tissue concentration, mg/l                      1.00                                   0
minimum tissue concentration, mg/l                      1.55            100.0
drugs ml or g per animal                               20.44

recommended dose, mg/kg                                   5.00
                                                                                10.0
withdrawal time slaughter, 24 hours                       1.00
prolongation of withdrawal time from plasma, hours        1.55
                                                                                         1.0
                                                                        Conc. (mcg/ml)




t1/2el, hours                                             2.75
t1/2ab, hours                                             2.70
F/V                                                       0.37                           0.1
F                                                        40.00

                                                                                         0.0


                                                                                         0.0
       0       1       1              2       2             3       3
10.0                                                  Plasma
                                                      Tissue
                                                      MIC
                                                      Plasmai
                                                      Tissuei




 1.0




 0.1
                           Days



           1   2   3              4       5       6             7


                                                  Jenunum

                                                  Colon

                                                  MIC




                           Days
                                 Time        n       Hours
Cmic               0.17
ka                 0.26                  1       1            1
ke                 0.25                  2       1            2
                                         4       1            4
aT                 0.05                  6       1            6
eT                 0.05                 12       1           12
tmax               5.44                  1       2           13
etmax              0.25                  2       2           14
Cmin               0.09                  4       2           16
Dv                 1.52                  6       2           18
Cmax               0.15                 12       2           24
Dp                 1.68                  1       3           25
cmaxcmic           0.91                  2       3           26
DpFakt             7.38                  4       3           28
DvFakt             6.70                  6       3           30
CmaxFakt           0.67                 12       3           36
CminFakt           1.03                  1       4           37
faktor,MIC         4.00                  2       4           38
                                         4       4           40
                                         6       4           42
Dpkorrekt          7.38                 12       4           48
                                         1       5           49
Dvkorrekt          6.70                  2       5           50
                                         4       5           52
Cmaxkorrekt        0.67                  6       5           54
Cminkorrekt        1.03                 12       5           60


medicin dyr       20.44
medicin i alt     20.44
pris               0.00




    Time      Stomac Duodenum   Jejunum_1 Jejunum_2 Ileum
    days       ug/g
        0.25    756.868  21.368 143.256      358.77  75.842
          0.5     11.56    8.62     12.41    157.06    28.91
            1     2.561   5.533     2.772     5.729    4.514
          1.5    0.2473  1.1572    0.9329    1.3344  2.7235
            2    2.3668  3.0654    3.0109    4.6475  2.4363
            3     0.182  1.0628    1.0638     1.411  1.7622
            4    0.4717  0.7534 0.91777 1.73876      1.7004
            6   0.06122 0.39987 0.54112      0.4793 0.58301
Zn dosis, ppm      2500
Foder/gang, kg       0.35
vægt, kg               10
Zn dosis, mg/kg       875


Lincomycin                         Jejunum
Dosis        mg/kg          4.02    1.64833
                                    0.72159
                                    0.02632
                                    0.00613
                                    0.02135
                                    0.00648
                                    0.00799
                                      0.0022
kaFVD/ka-ke enkeT          enketi      ekeT          enkaT      ekati          ekaT          Plasma     Tissue

     145.19         0.05        0.78          0.05       0.05           0.77          0.05       0.50       0.74
     145.19         0.05        0.60          0.05       0.05           0.60          0.05       0.77       1.16
     145.19         0.05        0.36          0.05       0.05           0.36          0.05       0.93       1.39
     145.19         0.05        0.22          0.05       0.05           0.21          0.05       0.84       1.25
     145.19         0.05        0.05          0.05       0.05           0.05          0.05       0.36       0.55
     145.19         0.00        0.78          0.05       0.00           0.77          0.05       0.80       1.20
     145.19         0.00        0.60          0.05       0.00           0.60          0.05       1.03       1.54
     145.19         0.00        0.36          0.05       0.00           0.36          0.05       1.10       1.65
     145.19         0.00        0.22          0.05       0.00           0.21          0.05       0.95       1.43
     145.19         0.00        0.05          0.05       0.00           0.05          0.05       0.40       0.60
     145.19         0.00        0.78          0.05       0.00           0.77          0.05       0.83       1.25
     145.19         0.00        0.60          0.05       0.00           0.60          0.05       1.05       1.57
     145.19         0.00        0.36          0.05       0.00           0.36          0.05       1.12       1.67
     145.19         0.00        0.22          0.05       0.00           0.21          0.05       0.96       1.45
     145.19         0.00        0.05          0.05       0.00           0.05          0.05       0.40       0.60
     145.19         0.00        0.78          0.05       0.00           0.77          0.05       0.83       1.25
     145.19         0.00        0.60          0.05       0.00           0.60          0.05       1.05       1.57
     145.19         0.00        0.36          0.05       0.00           0.36          0.05       1.12       1.68
     145.19         0.00        0.22          0.05       0.00           0.21          0.05       0.96       1.45
     145.19         0.00        0.05          0.05       0.00           0.05          0.05       0.40       0.60
     145.19         0.00        0.78          0.05       0.00           0.77          0.05       0.83       1.25
     145.19         0.00        0.60          0.05       0.00           0.60          0.05       1.05       1.57
     145.19         0.00        0.36          0.05       0.00           0.36          0.05       1.12       1.68
     145.19         0.00        0.22          0.05       0.00           0.21          0.05       0.96       1.45
     145.19         0.00        0.05          0.05       0.00           0.05          0.05       0.40       0.60




   Colon      Caecum

   171.044     604.646
   1135.32
   436.503      78.708
   43.8104      9.7317
   87.8152     19.9664
    2.9722      1.8359
    2.8816     1.83835
   0.47058     0.26127
Colon         Days          MIC
 0.78584137          0.25      32.00
 5.21609311           0.5      32.00
 2.00546127             1      32.00
 0.20128169           1.5      32.00
 0.40345652             2      32.00
 0.01365542             3      32.00
 0.01323917             4      32.00
 0.00216202             6      32.00
MIC          Days          Plasmai    Tissuei

      0.25          0.04       0.55        0.82
      0.25          0.08       0.85        1.27
      0.25          0.17       1.02        1.53
      0.25          0.25       0.92        1.38
      0.25          0.50       0.40        0.60
      0.25          0.54
      0.25          0.58
      0.25          0.67
      0.25          0.75
      0.25          1.00
      0.25          1.04
      0.25          1.08
      0.25          1.17
      0.25          1.25
      0.25          1.50
      0.25          1.54
      0.25          1.58
      0.25          1.67
      0.25          1.75
      0.25          2.00
      0.25          2.04
      0.25          2.08
      0.25          2.17
      0.25          2.25
      0.25          2.50
Reference: Forster et al 1982

Tiamulin, IM                                TYPE IN

MIC, µg/ml                                              1.50                                 0
postantibiotic time, hours                              2.40                  10.0
dosing interval, hours                                 12.00
tissue/plasma ratio                                     8.00

weight of animal, kg                                   50.00
number of animals                                       1.00
treatment period, 24 hours                              3.00




                                                                      Conc. (mcg/ml)
drug concentration, mg/ml or mg/g                     100.00
product price, kr./ml or g                              0.00                           1.0

                                            RESULTS
initial dose, [mg/kg] [ml or g/animal]                 12.11   6.06
maintenance dose, [mg/kg] [ml;g/animal]                 8.26   4.13

drugs in all, ml or g                                  26.71
expenses, kr.                                           0.00
                                                                                       0.1


                                            CONCENTRATIONS
maximum plasma concentration, mg/l                      0.75
minimum plasma concentration, mg/l                      0.33
maximum tissue concentration, mg/l                      6.00
minimum tissue concentration, mg/l                      2.64
drugs ml or g per animal                               26.71

recommended dose, mg/kg                                20.00
withdrawal time slaughter, 24 hours                    30.00
prolongation of withdrawal time from plasma, hours     -5.25


t1/2el, hours                                           7.26
t1/2ab, hours                                           0.85
F/V                                                     0.08
F, %
1   1   2      2   3             3

                       Plasma
                       Tissue
                       MIC
                       Plasmai
                       Tissuei




        Days
                        Time        n       Hours
Cmic             0.19
ka               0.81           1       1            1
ke               0.10           2       1            2
                                4       1            4
aT               0.00           6       1            6
eT               0.32          12       1           12
tmax             2.09           1       2           13
etmax            0.82           2       2           14
Cmin             0.15           4       2           16
Dv               3.73           6       2           18
Cmax             0.34          12       2           24
Dp               5.47           1       3           25
cmaxcmic         1.81           2       3           26
DpFakt          12.11           4       3           28
DvFakt           8.26           6       3           30
CmaxFakt         0.75          12       3           36
CminFakt         0.33           1       4           37
faktor,MIC       4.00           2       4           38
                                4       4           40
                                6       4           42
Dpkorrekt       12.11          12       4           48
                                1       5           49
Dvkorrekt        8.26           2       5           50
                                4       5           52
Cmaxkorrekt      0.75           6       5           54
Cminkorrekt      0.33          12       5           60


medicin dyr     26.71
medicin i alt   26.71
pris             0.00
kaFVD/ka-ke enkeT          enketi      ekeT          enkaT      ekati          ekaT          Plasma     Tissue

       0.71         0.32        0.91          0.32       0.00           0.44          0.00       0.33       2.63
       0.71         0.32        0.83          0.32       0.00           0.20          0.00       0.45       3.56
       0.71         0.32        0.68          0.32       0.00           0.04          0.00       0.46       3.64
       0.71         0.32        0.56          0.32       0.00           0.01          0.00       0.39       3.15
       0.71         0.32        0.32          0.32       0.00           0.00          0.00       0.23       1.80
       0.71         0.10        0.91          0.32       0.00           0.44          0.00       0.53       4.27
       0.71         0.10        0.83          0.32       0.00           0.20          0.00       0.63       5.05
       0.71         0.10        0.68          0.32       0.00           0.04          0.00       0.61       4.87
       0.71         0.10        0.56          0.32       0.00           0.01          0.00       0.52       4.17
       0.71         0.10        0.32          0.32       0.00           0.00          0.00       0.30       2.37
       0.71         0.03        0.91          0.32       0.00           0.44          0.00       0.60       4.79
       0.71         0.03        0.83          0.32       0.00           0.20          0.00       0.69       5.52
       0.71         0.03        0.68          0.32       0.00           0.04          0.00       0.66       5.26
       0.71         0.03        0.56          0.32       0.00           0.01          0.00       0.56       4.49
       0.71         0.03        0.32          0.32       0.00           0.00          0.00       0.32       2.56
       0.71         0.01        0.91          0.32       0.00           0.44          0.00       0.62       4.95
       0.71         0.01        0.83          0.32       0.00           0.20          0.00       0.71       5.67
       0.71         0.01        0.68          0.32       0.00           0.04          0.00       0.67       5.39
       0.71         0.01        0.56          0.32       0.00           0.01          0.00       0.57       4.59
       0.71         0.01        0.32          0.32       0.00           0.00          0.00       0.33       2.61
       0.71         0.00        0.91          0.32       0.00           0.44          0.00       0.63       5.01
       0.71         0.00        0.83          0.32       0.00           0.20          0.00       0.71       5.72
       0.71         0.00        0.68          0.32       0.00           0.04          0.00       0.68       5.43
       0.71         0.00        0.56          0.32       0.00           0.01          0.00       0.58       4.62
       0.71         0.00        0.32          0.32       0.00           0.00          0.00       0.33       2.63
MIC          Days          Plasmai    Tissuei

      1.50          0.04       0.48        3.86
      1.50          0.08       0.65        5.22
      1.50          0.17       0.67        5.34
      1.50          0.25       0.58        4.62
      1.50          0.50       0.33        2.64
      1.50          0.54
      1.50          0.58
      1.50          0.67
      1.50          0.75
      1.50          1.00
      1.50          1.04
      1.50          1.08
      1.50          1.17
      1.50          1.25
      1.50          1.50
      1.50          1.54
      1.50          1.58
      1.50          1.67
      1.50          1.75
      1.50          2.00
      1.50          2.04
      1.50          2.08
      1.50          2.17
      1.50          2.25
      1.50          2.50
Reference: Laber Schütze 1981

Tiamulin, PO                                TYPE IN
MIC extracellular, relevant for Lawsonia                2.00
MIC, µg/ml                                              0.10                                 0
postantibiotic time, hours                              2.40                           1.0
dosing interval, hours                                 12.00
tissue/plasma ratio                                     0.60

weight of animal, kg                                   50.00
number of animals                                       1.00
treatment period, 24 hours                              3.00




                                                                      Conc. (mcg/ml)
drug concentration, mg/ml or mg/g                     100.00
product price, kr./ml or g                              0.00                           0.1

                                            RESULTS
initial dose, [mg/kg] [ml or g/animal]                  8.56   4.28
maintenance dose, [mg/kg] [ml;g/animal]                 7.75   3.88

drugs in all, ml or g                                  23.66
expenses, kr.                                           0.00
                                                                                       0.0


                                            CONCENTRATIONS
maximum plasma concentration, mg/l                      0.67
minimum plasma concentration, mg/l                      0.14
maximum tissue concentration, mg/l                      0.40                                 0
minimum tissue concentration, mg/l                      0.08                  10.0
drugs ml or g per animal                               23.66

recommended dose, mg/kg                                 8.00
                                                                                       1.0
withdrawal time slaughter, 24 hours                     6.00
prolongation of withdrawal time from plasma, hours      0.34
                                                                                       0.1
                                                                      Conc. (mcg/ml)




t1/2el, hours                                           3.51
t1/2ab, hours                                           1.17
F/V                                                     0.11                           0.0
F, %                                                   90.00

                                                                                       0.0


                                                                                       0.0
    1       1       2          2       3                 3

                                               Plasma
                                               Tissue
                                               MIC
                                               Plasmai
                                               Tissuei




                    Days



1       2       3          4       5       6             7


                                           Jenunum

                                           Colon

                                           MIC




                    Days
                                 Time        n       Hours
Cmic               0.17
ka                 0.59                  1       1            1
ke                 0.20                  2       1            2
                                         4       1            4
aT                 0.00                  6       1            6
eT                 0.09                 12       1           12
tmax               1.93                  1       2           13
etmax              0.68                  2       2           14
Cmin               0.10                  4       2           16
Dv                 5.91                  6       2           18
Cmax               0.51                 12       2           24
Dp                 6.53                  1       3           25
cmaxcmic           3.05                  2       3           26
DpFakt             8.56                  4       3           28
DvFakt             7.75                  6       3           30
CmaxFakt           0.67                 12       3           36
CminFakt           0.14                  1       4           37
faktor,MIC         4.00                  2       4           38
                                         4       4           40
                                         6       4           42
Dpkorrekt          8.56                 12       4           48
                                         1       5           49
Dvkorrekt          7.75                  2       5           50
                                         4       5           52
Cmaxkorrekt        0.67                  6       5           54
Cminkorrekt        0.14                 12       5           60


medicin dyr       23.66
medicin i alt     23.66
pris               0.00




    Time      Stomac Duodenum   Jejunum_1 Jejunum_2 Ileum
    days       ug/g
        0.25    756.868  21.368 143.256      358.77  75.842
          0.5     11.56    8.62     12.41    157.06    28.91
            1     2.561   5.533     2.772     5.729    4.514
          1.5    0.2473  1.1572    0.9329    1.3344  2.7235
            2    2.3668  3.0654    3.0109    4.6475  2.4363
            3     0.182  1.0628    1.0638     1.411  1.7622
            4    0.4717  0.7534 0.91777 1.73876      1.7004
            6   0.06122 0.39987 0.54112      0.4793 0.58301
Zn dosis, ppm      2500
Foder/gang, kg      0.35
vægt, kg              10
Zn dosis, mg/kg      875


Tiamulin                          Jejunum
Dosis       mg/kg          0.78    0.31786
                                   0.13915
                                   0.00508
                                   0.00118
                                   0.00412
                                   0.00125
                                   0.00154
                                   0.00042
kaFVD/ka-ke enkeT          enketi      ekeT          enkaT      ekati          ekaT          Plasma     Tissue

       1.33         0.09        0.82          0.09       0.00           0.55          0.00       0.36       0.21
       1.33         0.09        0.67          0.09       0.00           0.31          0.00       0.49       0.29
       1.33         0.09        0.45          0.09       0.00           0.09          0.00       0.48       0.29
       1.33         0.09        0.31          0.09       0.00           0.03          0.00       0.37       0.22
       1.33         0.09        0.09          0.09       0.00           0.00          0.00       0.12       0.07
       1.33         0.01        0.82          0.09       0.00           0.55          0.00       0.46       0.27
       1.33         0.01        0.67          0.09       0.00           0.31          0.00       0.57       0.34
       1.33         0.01        0.45          0.09       0.00           0.09          0.00       0.53       0.32
       1.33         0.01        0.31          0.09       0.00           0.03          0.00       0.41       0.24
       1.33         0.01        0.09          0.09       0.00           0.00          0.00       0.13       0.08
       1.33         0.00        0.82          0.09       0.00           0.55          0.00       0.47       0.28
       1.33         0.00        0.67          0.09       0.00           0.31          0.00       0.58       0.35
       1.33         0.00        0.45          0.09       0.00           0.09          0.00       0.54       0.32
       1.33         0.00        0.31          0.09       0.00           0.03          0.00       0.41       0.25
       1.33         0.00        0.09          0.09       0.00           0.00          0.00       0.14       0.08
       1.33         0.00        0.82          0.09       0.00           0.55          0.00       0.47       0.28
       1.33         0.00        0.67          0.09       0.00           0.31          0.00       0.58       0.35
       1.33         0.00        0.45          0.09       0.00           0.09          0.00       0.54       0.32
       1.33         0.00        0.31          0.09       0.00           0.03          0.00       0.41       0.25
       1.33         0.00        0.09          0.09       0.00           0.00          0.00       0.14       0.08
       1.33         0.00        0.82          0.09       0.00           0.55          0.00       0.47       0.28
       1.33         0.00        0.67          0.09       0.00           0.31          0.00       0.58       0.35
       1.33         0.00        0.45          0.09       0.00           0.09          0.00       0.54       0.32
       1.33         0.00        0.31          0.09       0.00           0.03          0.00       0.41       0.25
       1.33         0.00        0.09          0.09       0.00           0.00          0.00       0.14       0.08




   Colon      Caecum

   171.044     604.646
   1135.32
   436.503      78.708
   43.8104      9.7317
   87.8152     19.9664
    2.9722      1.8359
    2.8816     1.83835
   0.47058     0.26127
Colon         Days          MIC
 0.15154237          0.25         2.00
 1.00587615           0.5         2.00
 0.38673498             1         2.00
 0.03881534           1.5         2.00
 0.07780292             2         2.00
 0.00263332             3         2.00
 0.00255305             4         2.00
 0.00041693             6         2.00
MIC          Days          Plasmai    Tissuei

      0.10          0.04       0.39        0.24
      0.10          0.08       0.54        0.32
      0.10          0.17       0.53        0.32
      0.10          0.25       0.41        0.24
      0.10          0.50       0.14        0.08
      0.10          0.54
      0.10          0.58
      0.10          0.67
      0.10          0.75
      0.10          1.00
      0.10          1.04
      0.10          1.08
      0.10          1.17
      0.10          1.25
      0.10          1.50
      0.10          1.54
      0.10          1.58
      0.10          1.67
      0.10          1.75
      0.10          2.00
      0.10          2.04
      0.10          2.08
      0.10          2.17
      0.10          2.25
      0.10          2.50
NO DATA PHARMAKOKINETIC DATA AVAILABLE

Valnemulin, PO                             TYPE IN
MIC extracellular, relevant for Lawsonia
MIC, µg/ml                                                                                         0
postantibiotic time, hours                                 2.40                     10.0
dosing interval, hours                                    12.00
tissue/plasma ratio

weight of animal, kg                                     50.00
number of animals                                         1.00
treatment period, 24 hours                                3.00




                                                                            Conc. (mcg/ml)
drug concentration, mg/ml or mg/g                       100.00
product price, kr./ml or g                                0.00

                                           RESULTS
initial dose, [mg/kg] [ml or g/animal]         #VALUE!            #VALUE!
maintenance dose, [mg/kg] [ml;g/animal]        #VALUE!            #VALUE!

drugs in all, ml or g                           #VALUE!
expenses, kr.                                   #VALUE!
                                                                                             1.0


                                           CONCENTRATIONS
maximum plasma concentration, mg/l             #VALUE!
minimum plasma concentration, mg/l             #VALUE!
maximum tissue concentration, mg/l             #VALUE!                                             0
minimum tissue concentration, mg/l             #VALUE!                              10.0
drugs ml or g per animal                       #VALUE!

recommended dose, mg/kg                                    4.00
withdrawal time slaughter, 24 hours                        1.00
prolongation of withdrawal time from plasma, hours #VALUE!
                                                                            Conc. (mcg/ml)




t1/2el, hours                              NO DATA
t1/2ab, hours                              NO DATA
F/V                                        NO DATA
F, %




                                                                                             1.0
    1       1       2          2       3                 3

                                               Plasma
                                               Tissue
                                               MIC
                                               Plasmai
                                               Tissuei




                    Days




1       2       3          4       5       6             7


                                           Jenunum

                                           Colon

                                           MIC




                    Days
                                 Time        n       Hours
Cmic             #DIV/0!
ka              #VALUE!                  1       1            1
ke              #VALUE!                  2       1            2
                                         4       1            4
aT              #VALUE!                  6       1            6
eT              #VALUE!                 12       1           12
tmax            #VALUE!                  1       2           13
etmax           #VALUE!                  2       2           14
Cmin             #DIV/0!                 4       2           16
Dv               #DIV/0!                 6       2           18
Cmax            #VALUE!                 12       2           24
Dp               #DIV/0!                 1       3           25
cmaxcmic        #VALUE!                  2       3           26
DpFakt           #DIV/0!                 4       3           28
DvFakt           #DIV/0!                 6       3           30
CmaxFakt        #VALUE!                 12       3           36
CminFakt         #DIV/0!                 1       4           37
faktor,MIC            4.00               2       4           38
                                         4       4           40
                                         6       4           42
Dpkorrekt       #VALUE!                 12       4           48
                                         1       5           49
Dvkorrekt       #VALUE!                  2       5           50
                                         4       5           52
Cmaxkorrekt     #VALUE!                  6       5           54
Cminkorrekt     #VALUE!                 12       5           60


medicin dyr     #VALUE!
medicin i alt   #VALUE!
pris            #VALUE!




    Time      Stomac Duodenum   Jejunum_1 Jejunum_2 Ileum
    days       ug/g
        0.25    756.868  21.368 143.256      358.77  75.842
          0.5     11.56    8.62     12.41    157.06    28.91
            1     2.561   5.533     2.772     5.729    4.514
          1.5    0.2473  1.1572    0.9329    1.3344  2.7235
            2    2.3668  3.0654    3.0109    4.6475  2.4363
            3     0.182  1.0628    1.0638     1.411  1.7622
            4    0.4717  0.7534 0.91777 1.73876      1.7004
            6   0.06122 0.39987 0.54112      0.4793 0.58301
Zn dosis, ppm      2500
Foder/gang, kg      0.35
vægt, kg              10
Zn dosis, mg/kg      875


Tiamulin                             Jejunum
Dosis       mg/kg          #VALUE!   #VALUE!
                                     #VALUE!
                                     #VALUE!
                                     #VALUE!
                                     #VALUE!
                                     #VALUE!
                                     #VALUE!
                                     #VALUE!
kaFVD/ka-ke enkeT       enketi    ekeT      enkaT     ekati     ekaT      Plasma    Tissue

 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!
 #VALUE!     #VALUE!    #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!   #VALUE!




   Colon     Caecum

   171.044    604.646
   1135.32
   436.503     78.708
   43.8104     9.7317
   87.8152    19.9664
    2.9722     1.8359
    2.8816    1.83835
   0.47058    0.26127
Colon      Days          MIC
 #VALUE!          0.25         0.00
 #VALUE!           0.5         0.00
 #VALUE!             1         0.00
 #VALUE!           1.5         0.00
 #VALUE!             2         0.00
 #VALUE!             3         0.00
 #VALUE!             4         0.00
 #VALUE!             6         0.00
MIC          Days          Plasmai   Tissuei

      0.00          0.04   #VALUE!   #VALUE!
      0.00          0.08   #VALUE!   #VALUE!
      0.00          0.17   #VALUE!   #VALUE!
      0.00          0.25   #VALUE!   #VALUE!
      0.00          0.50   #VALUE!   #VALUE!
      0.00          0.54
      0.00          0.58
      0.00          0.67
      0.00          0.75
      0.00          1.00
      0.00          1.04
      0.00          1.08
      0.00          1.17
      0.00          1.25
      0.00          1.50
      0.00          1.54
      0.00          1.58
      0.00          1.67
      0.00          1.75
      0.00          2.00
      0.00          2.04
      0.00          2.08
      0.00          2.17
      0.00          2.25
      0.00          2.50

				
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