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Leptospirosis Leptospirosis pathophysiology organism invade

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Leptospirosis Leptospirosis pathophysiology organism invade Powered By Docstoc
					Leptospirosis
         pathophysiology
organism invade the epithelium

proliferate & disseminates
        Heart - Pancarditis heart block
        RS     - Pulmonary haemorrhage
        CNS - Aseptic mengitis
        Renal - ARF
       Adrenal Haemorrhage - insufficiency
                  Treatment
Suppress org.                Fighting complications

• Penicillin 10000           • Proper hydration &
   U/Kg/d IV 6H -7d             electrolyte balance
(1 – 1.5 MU 4H - adults)     • Dialysis
• Doxycycline > 8y           ( prednisolone 30 – 60
   4mg/Kg/d – 7d                mg/d 7-10 d –prolong
• Ampicillin, Amoxycillin,      the dialysis)
   Cefotaxime
                   Sequela
• ARF - due to ATN , ITN
• ARDS
• Liver failure


         Prognosis
     Good
     Persistent headache in 1/3 rd of meningitis
     Uveitis – Persistent visual loss
     10% fatal in severe cases
     (in Weil’s disease)
     Deaths due to delayed diagnosis & pulmonary
      h’age
          Prevention

• Sanitary measures
• no vaccine available in humans
• Prophylactic A’biotics
   Doxycycline 200-250 mg once a week
   95% effective in adults
THANK
 YOU
IUUII

				
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posted:10/20/2011
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