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• Largest fatty organ in the body and essential for life
• Produces bile to help absorb fats and fat-soluble
• Removes or neutralizes poisons from the blood
• Produces immune cells to stop infection
• Removes germs and bacteria from the blood
• Makes proteins that regulate blood clotting
• Chief dysfunctions of liver:
   – Fatty Liver: fat deposits accumulate and choke the liver
   – Cirrhosis: Non-functioning scar tissue replaces healthy tissue; it
     is the 8th leading cause of death by disease, killing over 22,000
     people a year
                         Liver Stressors
•   Exposure to Chemicals, Toxins, Pharmaceutical Drugs, and Parasites. Many
    pesticides, petrochemicals, and environmental toxins are potent liver stressors.
    Acetaminophen can also stress the liver as can reactions to prescription drugs.
    Parasitic infection (schistosomiasis) can also contribute to cirrhosis.
•   Poor Diet. Excess intake of refined carbohydrates and sugars can cause fatty liver or
    liver degeneration over time. Diabetes, protein malnutrition, obesity, and
    corticosteroid treatment can also cause fatty liver.
•   Iron Overload. Excess iron in the diet can stress the liver, especially in individuals
    who are genetically unable to dispose of or sequester dietary iron (hemochromatosis).
    Creates a haemo-type liver pathology.
•   Nonalcoholic steatohepatitis (NASH) causes fat buildup and eventual cirrhosis in the
    liver This type of hepatitis appears to be associated with diabetes, protein
    malnutrition, obesity, coronary artery disease, and corticosteroid treatment.
•   Chronic hepatitis B and C. The hepatitis virus is a major cause of chronic liver disease
    and cirrhosis in the United States. Hepatitis viral infections cause inflammation and
    low-grade damage to the liver that eventually leads to cirrhosis and death.
•   Inherited diseases. Alpha-1 antitrypsin deficiency, Wilson's disease, galactosemia, and
    glycogen storage diseases are inherited disorders that result in malproduction,
    malprocessing, and malstorage by the liver of enzymes, proteins, and metals.
•   Blocked bile ducts. When the ducts that carry bile out of the liver are blocked, bile
    backs up and damages liver tissue (biliary cirrhosis).
       Symptoms of Stressed Liver
–   Loss of appetite
–   Nausea
–   Weakness
–   Weight loss
–   Edema and ascites. When the liver stops making albumin, water increases
    in the leg (edema) and abdomen (ascites).
–   Bruising and bleeding. Caused when liver slows production of clotting
–   Jaundice. Yellowing of the skin and eyes.
–   Itching. Bile products deposited in the skin may cause intense itching
–   Gallstones
–   Forgetfulness, poor concentration, or disturbed sleep
–   Sensitivity to medication. Because the liver does not remove drugs from
    the blood at the usual rate, drugs act longer than expected.
–   Portal hypertension. The flow of blood through the portal vein is slowed,
    which increases the pressure inside.
–   Varices. Blood from the intestines and spleen backs up into blood vessels in
    the stomach and esophagus. These vessels swell and are more likely to
–   Lowered immunity. Cirrhosis can result in immune system dysfunction,
    leading to infection.
•   Rice Bran (Oryza Sativa): Stabilized,            Broccoli Floret Powder (Brassica oleracea ssp.
    nonchemically treated. Contains gamma-           cymosa): high in sulphoraphane, which
    oryzanol, tocotrienols, tocopherols, squalene,   protects against cellular mutations
    ferulic acid, IP6 (inositol hexaphosphate)       Cucumber Powder (Cucumis sativus):
•   Spinach Powder (Spinacea oleracea): One of       100gram contains 5,160 iu vitamin A (516 RE),
    the highest known antioxidant foods (1,260       312 mcg folate, 3,456 mg vitamin K
    ORAC units/100g), rich in carotenoids (ie.,
    lutein, zeaxanthin), 9-cis-beta-carotene,        Peppermint Leaf (Mentha piperita): studied
    flavonoids, and p-coumaric acid derivatives      for its ability to protect against cellular
•   Tomato Flake (Lycospersicon esculentum):
    High in lycopene, a well-studied                 Anise (Pimpinella anisum): seed and EO
    antimutagen, as well as kaempferol and           Fennel (Foeniculum vulgare): seed and EO
    chlorogenic acid
                                                     Dill Leaf (Anethum graveolens)
•   Beet Root Powder (Beta vulgaris): High-
    pigment red phenotypes have been shown to        Barley Sprout Powder (Hordeum vulgare L.)
    have the best liver-protecting properties        Ginger Root Powder (Zingiber officinale Rosc.)
•   Flax Seed Bran (Linum usitatissimum): high in    Aloe Vera Extract (Aloe barbadensis)
    lignans, which prevent cellular mutations
•   Oat Bran (Avena sativa): high in immune          Slippery Elm, inner bark, (Ulmus fulva)
    supporting beta glucans                          Psyllium Seed Husk (Plantago ovata), a key
•   L-taurine: A sulfur-bearing amino acid that is   colon cleanser. A healthy liver requires a
    a key precursor to glutathione and essential     healthy colon
    for bile acid production in the liver
•   Rice Bran (Oryza Sativa): Stabilized,             •    Broccoli Floret Powder (Brassica oleracea ssp.
    nonchemically treated. Contains gamma-                 cymosa): high in sulphoraphane, protective
    oryzanol, tocotrienols, tocopherols,                   against cellular mutations; 890 TE/100g
    squalene, ferulic acid, IP6 (inositol             • Cucumber Powder (Cucumis sativus): 100
    hexaphosphate)                                         grams has 5,160 iu Vit. A, 312 mcg folate,
•   Spinach Powder (Spinacea oleracea): One of             3,456 mg Vit. K
    the highest known antioxidant foods (1,260        • L-taurine: Essential for bile acid formation
    ORAC units/100g), rich in mixed carotenoids
    (ie., lutein, zeaxanthin), 9-cis-beta-carotene,   • Dill Leaf (Anethum graveolens)
    flavonoids, and p-coumaric acid derivatives       • Barley Sprout Powder (Hordeum vulgare L.)
•   Tomato Flake (Lycospersicon esculentum):          • Ginger Root Powder (Zingiber officinale Rosc.)
    High in antimutagens lycopene, kaempferol,        • Aloe Vera Extract (Aloe barbadensis)
    and chlorogenic acid                              • Slippery Elm, inner bark, (Ulmus fulva)
•   Beet Root Powder (Beta vulgaris): High-           • Psyllium Seed Husk (Plantago ovata), a key
    pigment red phenotypes have been shown                 colon cleanser. A healthy liver requires a
    to have the best liver-protecting properties           healthy colon.
•   Flax Seed Bran (Linum usitatissimum): high        • Anise (Pimpinella anisum): seed and EO
    in lignans, which prevent cellular mutations      • Fennel (Foeniculum vulgare): seed and EO
•   Oat Bran (Avena sativa): high in immune-          ----------------------------------------------------------------
    supporting beta glucans
                                                      • Potassium Cloride
•   Peppermint Leaf (Mentha piperita): studied
    for its ability to combat cellular mutation.      • Real Salt (Redmond Utah)
                                                      • Cayenne Pepper (Capsium Annum)
         Beet Root Powder
• "High-pigment red phenotypes were most
  capable of ... inducing phase II
  [detoxifying] enzymes and antioxidant
   – M. Wettasinghe, University of Wisconsin-
     Madison, Madison, Wisconsin
• “Analysis of the data on the hepatocyte cytolysis,
  cholestasis, lipid peroxidation, and antioxidant system of
  blood serum showed that the preparations [beet juice,
  peppermint leaves] possess membranoprotector and
  antioxidant properties. This was manifested by a decrease
  in the activity of alanine aminotransferase and in the levels
  of total bilirubin and the final (malonaldehyde) and lipid
  peroxidation products.“
  — Olu Katikova, Department of Experimental and Clinical
  Pharmacology, Ul'yanovsk State University, Ul'yanovsk, Russia.
                                  Rice Bran
Rice Bran (Oryza Sativa) is rich in
• Gamma-oryzanol, a triterpene alcohol that is more effective than vitamin E in
  stopping oxidation of cholesterol.
• In studies at the Louisiana State University in Baton Rouge, researchers
  concluded that gamma-oryzanol “had activities higher than that of any of the 4
  vitamin E components. Gamma-oryzanol may be a more important antioxidant
  of rice bran in the reduction of cholesterol oxidation than vitamin E.”
    – Z. Xu et al., J Agric Food Chem. 2001.
• Tocotrienols and Tocopherols (Vitamin E). Rice bran is considered one of the
  best sources of alpha, beta, gamma, delta tocopherol and tocotrienol
• Squalene, an antimutagen also found in olive oil and shark liver oil.
• "Experimental studies have shown that squalene can effectively inhibit
  chemically-induced colon, lung and skin tumourigenesis in rodents.“
    – TJ Smith, University of South Carolina (Expert Opin Investig Drugs. 2000)
• "...the high squalene content of olive oil, as compared to other human foods, is a
  major factor in the cancer-risk reducing effect of olive oil.“
    – HL Newmark, Rockefeller University, New York (Ann N Y Acad Sci. 1999)
• Ferulic acid, an antioxidative, hypotensive polyphenol shown to reduce blood
    – Suzuki A et al., Short- and long-term effects of ferulic acid on blood pressure in
      spontaneously hypertensive rats. Am J Hypertens. 2002 Apr;15(4 Pt 1):351-7.
                         Rice Bran 2
Rice Bran (Oryza Sativa) is rich in
• IP6 (inositol hexaphosphate) and myo-inositol
    – IP6 is a strong chelating agent
    – myo-inositol is antimutagenic
    – myo-inositol and IP6 have been clinically studied for their effects
      against fatty liver at Hiroshima University in Japan. At physiologic
      dosages (0.1 -0.5% of diet), these compounds inhibit rises in hepatic
      total lipids and triglycerides resulting from administration of sucrose.
        • T. Katayama,Anticancer Res. 1999.
• A 1998 University of Maryland School of Medicine study found
  that IP6 reverses liver cancer in human liver cancer cell lines.
    – Vucenik I et al., (Anticancer Res. 1998).
• Researchers at the National Institute of Health Sciences, Tokyo,
  Japan, concluded that phytic acid in rice bran “inhibits hepatic and
  mammary carcinogenesis.“
    – Sugano M et al., (Anticancer Res. 1999)
                          Flax Seed
• Flax seed bran is exceptionally high in lignans, which
  prevent cellular mutations according to over 50 peer-
  reviewed clinical studies.
• The lignans in flax seed also protect the liver against
  over burden of toxins, according to recent university
  research (Rakuno Gakuen University, Ebetsu, Japan)
• "A lignan-containing flaxseed extract appears to protect
  liver cells against CCl(4)-induced necrosis.“
   – Endoh D et al., Rakuno Gakuen University, Ebetsu, Japan.
• Lignans have been well-documented to inhibit other
  human cancers. According to researchers at the
  University of Toronto, “flaxseed inhibits metastasis in
  human breast cancer.“
   – Dabrosin C et al., University of Toronto, Toronto, Canada.
            Broccoli Florets
• Broccoli is rich in antimutagens sulphoraphane
  and other isothiocyanates
• According to Cornell University scientists,
  “Broccoli possessed the highest total phenolic
  content, followed by spinach, yellow onion,
  red pepper, carrot, cabbage, potato.”
    – Y. Chu, Cornell University
• According to Havard University researchers,
  “Broccoli was associated with 25-30% reductions
  in CVD risk.”
    – Brigham and Women's Hospital and Harvard Medical School
• “Selenium-enriched broccoli effectively reduces colon cancer
    – Zeng et al., United States Department of Agriculture, Grand Forks
      Human Nutrition Research Center, North Dakota, USA
• “Brassica species, and broccoli in particular, are associated with
  reduced risk of several important cancers.”
    – JW Finley, United States Department of Agriculture, Grand Forks
      Human Nutrition Research Center, Grand Forks, ND, USA
• "Antiproliferative activities were also studied in vitro using HepG(2) human
  liver cancer cells. Spinach showed the highest inhibitory effect.“
    – YF Chu, Cornell University
• “When administered before and after DOX, natural spinach extract conferred
  the most significant cardiac protection. Pretreatment with natural spinach
  extract prevented increases in malondialdehyde H2O2/ hydroperoxides,
  decreased catalase and increased superoxide dismutase activities compared
  to the DOX group.”
    – Bar-Ilan University, Ramat Gan Israel
• "Neoxanthin from spinach significantly reduced cell viability to 10.9% for PC-
  3, 15% for DU 145 (prostate cell cancer lines).“
    – E Kotake-Nara E, Hokkaido University
• "A total of 927 freeze-dried vegetable samples … were analyzed using the
  oxygen radical absorption capacity (ORAC) and ferric reducing antioxidant
  capacity (FRAP) methods. On the basis of the ORAC results, green pepper,
  spinach, purple onion, broccoli, beet, and cauliflower are the leading sources
  of antioxidant activities against the peroxyl radicals.“
    – Ou B et al., Brunswick Laboratories
• "Active components in tomato, such as
  kaempferol and chlorogenic acid, have
  antimutagenic activities and lycopene is
  the most active oxygen quencher with potential chemopreventive
   – A. Sengupta, Department of Cancer Chemoprevention, Chittaranjan
     National Cancer Institute, Kolkata, India.
• "Several studies have shown an inverse association between tomato
  products or lycopene consumption and prostate cancer.“
   – RP Gallagher, CL Kutynec, University of British Columbia, Vancouver,
     British Columbia
• "Cardioprotective functions provided by the nutrients in tomatoes
  may include the reduction of low-density lipoprotein (LDL)
  cholesterol, homocysteine, platelet aggregation, and blood
   – JK Willcox et al., North Carolina State University
• Recent studies show that the sulfur-bearing amino acid, L-taurine,
  increases bile flow and reduces peroxidative (free radical) damage
  in the liver.
    – AT Nandhini et al, Indian J Exp Biol. 2002.
    – T Kishida et al., J Nutr Biochem. 2003 Jan;14(1):7-16.
• Research at the University of Bonn in 2003 showed that taurine
  was just as effective as SOD (superoxide dismutase) in reducing
  injury to the liver in reperfusion studies. Taurine reduced both
  lipid peroxidation and enzyme release, while at the same time
  increasing liver bile production.
    – Lauschke et al., Surgical Research Divison, University of Bonn,
• Investigators at University of Shizuoka in Japan found that taurine
  increase fecal bile acid excretion, crucial is ridding the body of
  toxins as well as excess LDL cholesterol.
    – H Yokogoshi and H Oda, Amino Acids, 2002

• Helichrysum (Helichrysum italicum)
  – flowering top
• Ledum (Ledum groenlandicum)
  – leaf
• Celery (Apium graveolens)
  – seed
• Enzyme complex
    –   Protease 3.0
    –   Protease 4.5
    –   Protease 6.0
    –   Amylase
    –   Peptidase
    –   Bromelain 600
    –   Cellulase
    –   Lipase
    –   Phytase
•   Calcium carbonate
•   Fructose
•   Apple Syrup
•   Alfalfa powder
•   Carrot powder
– Pancreatin 4x
– Pancrelipase
– Trypsin
– Thymus Extract
– Bromelain
– Papain
– Betaine HCl
– Alfalfa leaf
– Carrot powder
– Cumin Seeds
   •   Tarragon EO
   •   Anise EO
   •   Fennel EO
   •   Peppermint EO
   •   Clove EO

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