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					                                                           Molecular Medicine
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                    Identification of Marker Genes for Differential Diagnosis of

                    Chronic Fatigue Syndrome
UNCORRECTED PROOF


                    Takuya Saiki, MD, 1 Tomoko Kawai, PhD, 2 Kyoko Morita, PhD,2 Masayuki Ohta, PhD,

                    3
                        Toshiro Saito, PhD, 3 Kazuhito Rokutan, MD, PhD, 2* Nobutaro Ban, MD, PhD 1




                    1
                        Department of General Medicine, Nagoya University Hospital, Nagoya, Japan

                    2
                        Department of Stress Science, Institute of Health Biosciences, University of Tokushima


                    Graduate School, Tokushima, Japan

                    3
                        Life Science Group, Hitachi, Ltd., Saitama, Japan




                    Running title: Marker genes for CFS




                    *Address correspondence and requests for reprints to Kazuhito Rokutan


                    Department of Stress Science, Institute of Health Biosciences, Graduate School of


                    Medicine, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho,


                    Tokushima 770-8503, Japan


                    Phone: +81-88-633-9007        Fax: +81-88-633-9008


                    E-mail: rokutan16@basic.med.tokushima-u.ac.jp




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                    KEYWORDS: prolonged fatigue, stress, gene expression, peripheral blood cells,
UNCORRECTED PROOF

                    microarray




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                    ABSTRACT

                    Chronic fatigue syndrome (CFS) is a clinically defined condition characterized by long-lasting
UNCORRECTED PROOF

                    disabling fatigue. Because of the unknown mechanism underlying this syndrome, there is still


                    no specific biomarker for objective assessment of the pathological fatigue. We have compared


                    gene expression profiles in peripheral blood between 11 drug-free patients with CFS and age-


                    and sex-matched healthy subjects using a custom microarray carrying complementary DNA


                    probes for 1,467 stress-responsive genes. We identified 12 genes whose mRNA levels were


                    significantly changed in CFS patients. Of these 12 genes, quantitative real-time PCR validated


                    the changes in 9 genes encoding granzyme in activated T or natural killer cells (GZMA),


                    energy regulators (ATP5J2, COX5B, and DBI), proteasome subunits (PSMA3 and PSMA4),


                    putative protein kinase c inhibitor (HINT), GTPase (ARHC), and signal transducers and


                    activators of transcription 5A (STAT5A). Next, we performed the same microarray analysis on


                    3 additional CFS patients and 20 other patients with the chief complaint of long-lasting


                    fatigue related to other disorders (non-CFS patients) and found that the relative mRNA


                    expression of 9 genes classified 79% (11/14) of CFS and 85% (17/20) of the non-CFS


                    patients. Finally, real-time PCR measurements of the levels of the 9 involved mRNAs were


                    done in another group of 18 CFS and 12 non-CFS patients. The expression pattern correctly


                    classified 94% (17/18) of CFS and 92% (11/12) of non-CFS patients. Our results suggest that


                    the defined gene cluster (9 genes) may be useful for detecting of pathological responses in




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                    CFS patients and for differential diagnosis of this syndrome.
UNCORRECTED PROOF

                    (250 words: limit, 250 words)




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                    INTRODUCTION

                    Chronic fatigue syndrome (CFS) is a clinically defined condition characterized by long-lasting
UNCORRECTED PROOF

                    disabling fatigue, resulting in severe impairment in daily functioning and associated


                    symptoms such as memory and concentration difficulties, muscle aches, sleep disturbances,


                    and headache (1). CFS poses a diagnostic challenge because of the unknown mechanism


                    underlying this syndrome and the difficulty in making an objective assessment of pathological


                    fatigue.


                       Several groups have been searching for reliable biomarkers for diagnosing CFS and have


                    shown altered gene expression profiles in peripheral blood leukocyte populations, which can


                    distinguish the majority of CFS cases (2-5). Recently, a data-intensive analysis has been


                    successfully conducted by the Wichita CFS project (6). In the 2-day in-hospital study, gene


                    expression levels of 20,000 genes in isolated peripheral blood mononuclear cells were


                    analyzed to identify biologically and clinically meaningful signatures of gene expression


                    relevant to classification, diagnosis, and treatment of CFS (6).


                       Peripheral leukocytes express receptors for stress mediators, such as hormones,


                    neurotransmitters, growth factors, and cytokines. Also, leukocytes produce a number of


                    mediators,     including      cytokines,     some      of     which   can     activate       the


                    hypothalamus-pituitary-adrenal (HPA) axis (7). Leukocytes may be potential targets for


                    mediators eliciting pathological responses associated with stress-related disorders. CFS has




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                    been hypothesized to involve an abnormal response to various stressful experiences such as


                    infection, overwork, or psychological stresses resulting in immunologic dysfunction,
UNCORRECTED PROOF

                    dysregulation of the HPA axis, and dysautonomia (8-11). At the same time, psychological and


                    sociocultural factors, when present in patients with CFS, also influence the severity of the


                    illness and treatment outcome (8-10). In fact, CFS is frequently accompanied by psychiatric


                    disorders such as mood disorders, and the clinical manifestations of these two conditions


                    partly overlap. Therefore, it is important that physicians are able to make the differential


                    diagnosis between CFS and mood disorders, particularly major depression. However, at


                    present, we have no reliable laboratory tool linking or separating these two disease states (10).


                       We developed a custom cDNA microarray specifically designed to measure mRNA levels


                    of stress-responsive 1,467 genes in blood (12). Using this microarray, a whole-blood RNA


                    collection system, and real-time PCR, we have identified a cluster of 9 genes in blood as


                    marker genes useful for differential diagnosis of CFS.




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                    MATERIALS AND METHODS
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                    Subjects

                    The present study was approved by the institutional review boards of the Nagoya University


                    School of Medicine. After the experimental procedures were fully explained, written informed


                    consent was obtained from all patients. All procedures were in accordance with the


                    institutional guidelines and the Helsinki Declaration. Patients were recruited from a series of


                    patients referred to the Department of General Medicine, Nagoya University Hospital,


                    Nagoya, Japan. Initially, 11 patients with CFS (4 males and 7 females; aged 33.4 ± 9.4 years)


                    were selected according to the Centers for Disease Control and Prevention criteria for CFS


                    (1). Next, for a discriminating analysis of CFS versus non-CFS patients, 3 patients with CFS


                    and 20 patients who presented with the chief complaint of general fatigue related to other


                    disorders (non-CFS patients) were additionally enrolled in microarray analysis. Finally, 18


                    CFS and 12 non-CFS patients were newly enrolled in quantitative real-time PCR assay for


                    checking the validity of differential diagnosis. We obtained clinical information concerning


                    current disability, duration of illness, number and nature of accompanying symptoms (Table


                    1), the clinical data on blood chemistry, and complete blood cell counts (CBC)


                    (supplementary Table 1) by standard laboratory tests. All CFS and non-CFS patients were


                    consulted to a psychiatrist who was accustomed to seeing CFS patients to confirm the




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                    diagnosis. Age- and sex-matched healthy volunteers were randomly recruited to each


                    experiment as controls. The controls were free of medication and underwent comprehensive
UNCORRECTED PROOF

                    medical examination for past and current health problems.




                    Measures

                    RNA preparation, amplification, and hybridization. Venous blood (5 or 10 ml) was taken


                    from patients and healthy volunteers under fasting conditions before lunch. Whole blood was


                    directly poured into the PAXgene Blood RNA tube (Becton Dickinson, Franklin lakes, NJ,


                    USA). Total RNA was extracted from the whole blood mixture using a PAXgene Blood RNA


                    kit (Qiagen, Hilden, Germany) according to the manufacturer’s protocol. Contaminating DNA


                    was removed using an RNase-free DNase kit included in the PAXgene Blood RNA kit


                    (Qiagen). The quality of the purified RNA and its applicability for microarray analysis was


                    assessed by the Agilent 2100 Bioanalyzer using an RNA 6000 Nano Labchip kit (Agilent


                    Technologies, Palo Alto, CA, USA). Quality of RNA was considered to be acceptable when


                    the RIN value was > 8.0. All RNA samples fulfilled this criterion. The labeling of RNA was


                    done by an indirect amino-allyl labeling methodology. Five μg of total RNA was first reverse

                    transcribed with oligo dT primer conjugating T7 sequence. The yield of first strand cDNA


                    complementary to poly(A) RNA was amplified by using a MEGAscript T7 in vitro RNA


                    transcription kit (Applied Biosystems, Foster City, CA, USA). Amplified RNA (6 μg) was




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                    reverse transcribed by using random hexamer and aminoallyl-dUTP. The synthesized cDNA


                    was labeled by reaction with a dye (NHS-ester Cy5 or Cy3; Amersham Biosciences,
UNCORRECTED PROOF

                    Piscataway, NJ, USA). Cy5-cDNAs prepared from each patient were mixed with the


                    equivalent amount of Cy3-cDNAs from the respective healthy subject, and the mixture was


                    applied to the cDNA microarray. Hybridization was performed at 62ºC for 12 h. After


                    washing, fluorescence intensity at each spot was assayed using a scanner (ScanArray 5000;


                    GSI-Lumonics, Billerica, MA, USA).




                    Microarray analysis. The construction of our microarray has already been described (12). To


                    minimize non-specific hybridization reactions mainly with hemoglobin RNAs, we selected


                    1,467 genes whose mRNAs were confirmed to be detectable in whole blood RNA samples by


                    reverse transcriptase-PCR. The genes carried on our cDNA microarray are categorized into


                    stress hormones, neurotransmitters, cytokines, growth factors, receptors, signal transduction


                    molecules, transcription factors, heat shock proteins, growth- or apoptosis-associated factors,


                    metabolic enzymes, and others (see supplementary data).


                       Signal intensities of Cy5 and Cy3 were quantified and analyzed by subtracting


                    backgrounds, using the QuantArray software (GSI-Lumonics). The global normalization was


                    performed by scaling the Cy3 signal intensities to the median Cy5:Cy3 ratio. The normalized


                    values for duplicate cDNA probes were averaged. Then, we selected 1,072 genes having




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                    fluorescence intensities higher than a cut-off value of 300 in either Cy5 or Cy3 conditions


                    among all samples. The relative expression values (Cy5/Cy3) for 1,072 genes were subjected
UNCORRECTED PROOF

                    to hierarchical clustering using the GeneSpring 7.3 software (Agilent). Average linkage and


                    cosine θ were used for clustering algorithm and the calculations of distance metric,


                    respectively. After Cy5/Cy3 ratios of 1,072 genes were transformed to logarithm base 2,

                    statistical significance between CFS patients and age- and sex-matched controls was


                    examined by the paired t-test statistic using the Cyber-T stats program written in the R stats


                    language    (see    http://cybert.microarray.ics.uci.edu/help/index.html)   (13).   Statistical


                    significance was defined as a Bonferroni-corrected P value of <0.05, after the problem of a


                    multiple test was addressed.




                    Quantitative real-time PCR. cDNA was prepared from total RNA (0.5 μg) using oligo dT


                    primer according to the instructions of SuperScript™ II reverse transcriptase kit (Invitrogen,


                    Carlsbad, CA, USA). The mRNA levels of 10 target genes based on GenBank accession


                    numbers (Table 2) were analyzed by quantitative real-time PCR using predesigned,


                    gene-specific TaqMan probes and primer sets (search the batch ID for each gene in Table 2 at


                    https://products.appliedbiosystems.com/ab/en/US/adirect/ab?cmd=ABGEBatchSearch)             and


                    the ABI-PRISM 7500 sequence detection system (Applied Biosystems, Foster City, CA,


                    USA). Appropriate predesigned TaqMan probe and primer sets for detecting specifically




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                    mRNA types of COX7C and HSPA2 were not available because of their gene structure


                    (Applied Biosystems). Each PCR reaction was performed according to the protocol of
UNCORRECTED PROOF

                    TaqMan Universal PCR Mastermix (Applied Biosystems), and data were analyzed using SDS


                    2.2 software (Applied Biosystems). A no template control and a no RT step control were also


                    run for every reaction in order to see the amplification was not off genomic DNA.


                    Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as an endogenous quantity


                    control, and quantity values were normalized to GAPDH mRNA expression. After the relative


                    ratio of each mRNA between CFS patients and control subjects was calculated, the unpaired


                    t-test was performed to compare the relative ratio for each gene in the microarray (n = 11)


                    versus quantitative real time PCR results (n = 11). Finally, we also examined relative mRNA


                    ratios of the target genes in newly enrolled 18 CFS and 12 non-CFS patients using age- and


                    sex-matched healthy subjects as controls by quantitative real-time PCR.




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                    RESULTS
UNCORRECTED PROOF

                    Clinical features of CFS patients

                    The initially enrolled 11 patients with CFS comprised 4 males and 7 females whose median


                    age was 33.4 ± 9.4 years. The clinical features of the 11 patients are shown in Table 1. All


                    patients were complaining of debilitating fatigue lasting for longer than one year, and the


                    median duration of fatigue was 4.9 years. Five patients (patient Nos. 3, 6, 7, 9, and 10)


                    reported some linkage between infectious episodes and onset of their symptoms, but none of


                    them were positive for serum antibody against Coxiella burnetti (Q fever) that could trigger


                    CFS-like symptoms (14), human herpes viruses type 6 and 7, Epstein-Barr virus or


                    cytomegalovirus (data not shown). Biochemical data also demonstrated the absence of current


                    active infection (data not shown). CBC of one patient (No. 6) was not measured at the time of


                    sampling for microarray analysis, since the medical record from another hospital described no


                    abnormalities in CBC and leukocyte populations. CBC data and white blood cell differential


                    counts of the other patients were normal (Supplementary Table 1). All 11 patients showed


                    normal BMI values (20.3 ± 2.2, means ± SD) (Supplementary Table 1). Three CFS patients


                    (Nos. 2, 6, and 9) had past histories of major depression or adjustment disorder. We consulted


                    the psychiatrist and confirmed that these disorders were not active during the experimental


                    period. Three months prior to enrollment in this study all patients were removed from




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                    medications being taken.
UNCORRECTED PROOF

                    Gene expression profile in patients with CFS

                    Hierarchical cluster analysis of 1,072 genes whose fluorescence intensities were higher than a


                    cut-off value of 300 in either Cy5 or Cy3 conditions among all samples suggested the


                    presence of genes that commonly changed among all patients, compared with age- and


                    sex-matched controls (data not shown). The statistic analysis of 1,072 genes (paired t-test;


                    Bonferroni (experiment-wide false positive rate) adjusted P-value = 0.05) identified 12 genes


                    whose mRNA levels were significantly changed in CFS patients, compared with the healthy


                    controls (Figure 1). Several up-regulated genes were categorized into regulators of energy


                    metabolism; a mitochondrial ATP subunit (ATP5J2; f subunit of the F0 complex),


                    nuclear-encoded subunits of the mitochondrial cytochrome c (COX7C and COX5B), and an


                    intracellular acyl-coenzyme A transporter (DBI). The significantly up-regulated genes also


                    contained a cytotoxic T lymphocyte- and natural killer cell-specific serine protease, granzyme


                    A (GZMA), a member of the ras homolog gene family (ARHC), and proteasome subunits


                    (PSMA3 and PSMA4). The mRNA levels of two other genes encoding a protein with unknown


                    function (KIAA0194) and a putative protein kinase C inhibitor of the HINT family (HINT)


                    were also significantly elevated. In contrast, CFS patients showed decreased mRNA levels of


                    heat shock 70-KDa protein 2 (HSPA2) and a member of the signal transducer and activator of




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                    transcription (STAT) family of transcription factors (STAT5A).
UNCORRECTED PROOF

                    Quantitative real-time PCR

                    Although we applied the indirect labeling method to reduce the extent of cyanine dye bias in


                    our microarray assay, there may be some concerns regarding the possibility of the genes


                    exhibiting some dye-bias in dual-labeled spotted cDNA microarrays. Therefore, we performed


                    TaqMan real-time PCR to validate the microarray data. The mRNA levels of two genes


                    (COX7C and HSPA2) were not measured, since appropriate TaqMan probes for these genes


                    were not available. As for the rest of genes, we confirmed that each PCR reaction had a


                    similar efficiency of reaction when we checked the slope in a standard curve for each PCR


                    reaction using the same total RNA from whole blood as standard (Table 2). Among the 10


                    mRNA levels measured, real-time PCR did not demonstrate any significant change in the


                    KIAA0194 mRNA level, while the other 9 mRNA levels in CFS patients were confirmed to be


                    significantly changed (Figure 2).




                    Microarray analysis of CFS and non-CFS patients with prolonged fatigue

                    To test whether gene expression profiling could be useful for differential diagnosis of CFS, 3


                    CFS patients and 20 patients who presented with the chief complaint of general fatigue related


                    to other disorders (non-CFS patients) were additionally enrolled in this study. Relative gene




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                    expression levels of the CFS and non-CFS patients were also measured by the dual-labeled


                    cDNA microarray using age- and sex-matched healthy subjects as controls. RNA samples
UNCORRECTED PROOF

                    from the newly added patients (3 CFS and 20 non-CFS) and age- and sex-matched healthy


                    controls were labeled Cy5 and Cy3, respectively. All 20 non-CFS patients complained of


                    abnormal fatigue lasting for more than 6 months, while their clinical features did not


                    completely meet the CDC criteria for CFS (Table 1). First, we compared gene expression


                    profiles of 1,072 genes in 14 CFS patients, including 3 additionally enrolled patients, and 20


                    non-CFS patients. Hierarchical cluster analysis of the relative mRNA levels of 1,072 genes


                    showed that gene expression patterns could be roughly classified into CFS and non-CFS


                    patterns, but it was difficult to draw a margin between the two patterns (data not shown).


                       Next, we tested whether the changes in 9 genes, whose expressions were confirmed to be


                    significantly changed between 11 CFS patients and healthy subjects by both microarray


                    (Figure 1) and quantitative real-time PCR (Figure 2), could exclude non-CFS patients. As


                    shown in Figure 3, the hierarchical clustering of the expression of 9 genes classified 34


                    patients into two (groups A and B) or three groups (groups A, B1, and B2). Group A branches


                    contained 13 CFS patients and 3 non-CFS patients (mood disorder, 30 year-old female;


                    somatoform disorder, 24 year-old female; personality disorder, 45 year-old female). Among


                    10 branches of group B1, only one CFS patient was included. All branches of group B2 were


                    composed of non-CFS patients. Thus, the cluster analysis of relative mRNA levels of 9 genes




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                    measured by the microarray suggested that the 9 marker genes might be useful for differential


                    diagnosis of CFS.
UNCORRECTED PROOF


                    Use of 9 marker genes for differential diagnosis of CFS

                    Finally, we tested whether the 9 marker genes could be useful for differential diagnosis of


                    CFS. To correctly assess this issue, we omitted the 11 patients in whom we had identified the


                    9 genes. A total of 18 newly enrolled CFS patients and 12 non-CFS patients (Table 1) were


                    subjected to quantitative real time RT-PCR analysis using GAPDH mRNA as an endogenous


                    quantity control. Age- and sex-matched healthy subjects (total 30 subjects) were also used as


                    controls of individual patients. As shown in Figure 4A, the expression levels of 6 genes


                    (PSMA4, PSMA3, HINT1, DBI, GZMA, and ATHC) out of 9 genes in 18 CFS patients were


                    significantly different from that in 12 non-CFS patients. The hierarchical clustering of the


                    expression of 9 genes classified 30 patients into two groups (a and b) (Figure 4B). Group a


                    branches contained 17 CFS patients and 1 non-CFS patient (major depression, 37 F). Among


                    12 branches of group b, one case of CFS was included. Thus, the expression pattern of 9


                    genes could distinguish the majority of our CFS patients from non-CFS patients.




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                    DISCUSSION
UNCORRECTED PROOF

                       The microarray or differential display approach has been used to examine the


                    CFS-specific gene expression in peripheral blood mononuclear cells (2-5). Two sources are


                    commonly used for preparation of RNA, whole blood or its leukocyte populations (15).


                    Because of advantages and disadvantages associated with both systems (16-20), at present


                    there is no consensus regarding the optimal technique for isolation of RNA from peripheral


                    blood. A whole-blood RNA collection system is attractive particularly in clinical settings,


                    since the RNA isolation method is easy to use and reduces operator time and sample volume.


                    In addition, this system reduces the risk of exposure of laboratory personnel to biohazards


                    relative to the risk involved in isolation of leukocyte populations.


                       Using RNA from whole blood, we show here that both microarray analysis and real-time


                    PCR identify 9 genes whose mRNA expression are significantly different in 11 patients with


                    CFS, compared with age- and sex-matched healthy controls. Although the individual genes


                    identified as CFS-related genes did not overlap with those identified in other studies (2-5), a


                    majority of them could be categorized into distinct clusters, including host defense, energy


                    metabolism, or small G protein-dependent signal transduction (2-5). The significance of our


                    study can be considered from the three different perspectives.


                       First, the identified genes are informative in considering the pathophysiology of CFS. The




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                    up-regulated GZMA encodes a T cell- and natural killer cell-specific serine protease that


                    functions as a common component necessary for lysis of target cells by these cytotoxic cells.
UNCORRECTED PROOF

                    The proteasome subunits PSMA3 and PSMA4 were also up-regulated. The proteasome is the


                    central proteolytic system that also plays an important role in the major histocompatibility


                    complex-class I antigen processing. Previous studies identified genes involved in T cell


                    activation (2-5). Our findings also suggest that patients with CFS may have altered immunity,


                    such as that involved in anti-viral defense. As reported in other studies (3, 5), we have also


                    identified genes encoding molecules catalyzing oxidative phosphorylation in mitochondria


                    (COX5B and ATP5J2). COX5B and ATP5J2 encode a cytochrome c oxidase subunit and a


                    subunit of the mitochondrial proton channel, respectively. Although we were unable to


                    measure the mRNA level of another cytochrome c oxidase subunit (COX7C) by real time


                    PCR, these nuclear-encoded subunits (COX5B and COX7C) function in the regulation and


                    assembly of the cytochrome c oxidase complex and mitochondrial ATPase. In addition, our


                    CFS patients had significantly increased DBI mRNA levels. The diazepam binding inhibitor


                    (DBI) is known as a GABA receptor modulator or acyl-coenzyme A (acyl-CoA) binding


                    protein (ACBP). ACBP binds thiol esters of long fatty acids and coenzyme A in a one-to-one


                    binding mode with high specificity and affinity. This molecule is suggested to act as an


                    intracellular acyl-CoA transporter and form a pool of ACBP-acyl-CoA complex that is an


                    important intermediate in lipid synthesis and fatty acid degradation and participates in




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                    regulating intermediary metabolism and gene expression. The increased mRNA expression of


                    DBI, COX5B, and ATP5J2 strongly suggests abnormalities in energy metabolism in our CFS
UNCORRECTED PROOF

                    patients.


                        We also found that the STAT5A mRNA level was significantly decreased in CFS patients.


                    The protein encoded by STAT5A is a member of the STAT family of transcription factors.


                    STAT-5 mediates the signal transduction triggered by various cell ligands, such as IL2, IL4,


                    colony-stimulating factor 1, and growth hormones. Adult growth hormone deficiency


                    (AGHD) is a CFS-like disorder characterized by fatigue, tiredness, and myalgia, and


                    replacement therapy with human growth hormone improves these symptoms (21). Growth


                    hormone activates STAT1, 3, 5A and 5B in different cell systems (22). Webb et al. reported


                    that STAT-5 isoform, but not STAT-1 or STAT3, were markedly increased in skeletal muscles


                    in patients with AGHD and suggested that the STAT5 signal transduction pathway in skeletal


                    muscle might be abnormal in AGHD (21). The decreased expression of STAT5A mRNA in


                    peripheral blood cells from CFS patients suggests that the abnormality in STAT5 signaling


                    might be associated with symptoms of CFS.


                            In the Wichita study directed by CDC (6), fatigue-associated gene expression patterns


                    in isolated blood mononuclear cells were identified by several groups sharing the same data


                    sets. Most of the groups in that study did not divide subjects into CFS and non-CFS cases by


                    CDC classification but focused instead on fatigue itself and accompanying symptoms for




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                    elucidation of fatigue-associated genes. It was confirmed that nine of 16 genes reported by


                    Kaushik et al. as differentially expressed genes in CFS (5) also were included among
UNCORRECTED PROOF

                    fatigue-associated genes measured by quantitative trait analysis (QTA) in the Wichita study


                    (23). Our study also revealed that 2 genes, STAT5A and COX5B, were categorized in the same


                    pathways as STAT5B and COX7A2, which were identified as fatigue-associated genes


                    according to QTA. STAT5A and COX5B belong to the Jak-STAT signaling pathway and


                    oxidative phosphorylation pathway, respectively. Furthermore, Fang et al. in the Wichita


                    study succeeded in separating CFS from non-CFS patients based on expression profiles of 24


                    genes that were differentially expressed in subjects between those who received high scores


                    and low scores in both multidimensional fatigue inventory scores and the Zung depression


                    scale (24). The reported 24 genes included ACBD6 that encodes one of the acyl-CoA-binding


                    proteins. Another homologue of the acyl-CoA-binding proteins, DBI (ACBD1), was


                    up-regulated in our CFS cases. The Wichita study was a population-based study, while our


                    data are based on a clinical cohort. Despite the fact that we used a different RNA preparation


                    method and a different microarray platform, there was a significant overlap between our


                    results and those of the Wichita study.


                        Second, most of the non-CFS patients in our study were psychiatric disorders, which


                    usually present a challenge for the clinicians to differentiate. Thus, the present study may


                    provide a potential tool to clinicians who see chronically fatigued patients in daily practice




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                    with no objective marker for CFS.


                       Third, the expression pattern of the 9 marker genes did not distinguish all of our clinically
UNCORRECTED PROOF

                    diagnosed CFS cases, since they include heterogeneous populations. However, identification


                    of a group of CFS patient having this unique expression pattern will be useful for future


                    treatment studies.


                       With regard to the limitations of our study, although we could not detect any common


                    abnormality in the CBC and leukocyte subpopulations of our CFS cases, the use of whole


                    blood RNA could not rule out heterogeneity of the cell population and the potential diversity


                    of the cell-specific responses. The second concern is that microarrays carrying different gene

                    probes may pick up different groups of genes. Although our microarray carries cDNA probes


                    for 1,467 genes that have been confirmed to be actually detectable by reverse transcription


                    PCR, more genome-wide examinations in larger numbers of cases may reveal additional


                    marker genes for CFS. However, we also found that the expression pattern of 9 genes


                    measured by the microarray could classify 79% (11/14) of CFS and 85% (17/20) of non-CFS


                    patients. Finally, real-time PCR measurement of the 9 mRNA levels in another group of


                    subjects (18 CFS and 12 non-CFS patients) classified 94% (17/18) of CFS and 92% (11/12) of


                    non-CFS patients. A clinical trial of a larger number of CFS and non-CFS patients with


                    long-lasting fatigue is now under way.




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                    ACKNOWLEDGEMENTS

                    The authors thank Dr. Tetsushi Yoshikawa (Fujita Healthscience University) for his
UNCORRECTED PROOF

                    measurements of the titers of HHV6 and 7, Drs Motohiko Ogawa (National Infectious


                    Disease Research Center) and Yumiko Furuya (Kanagawa Health Research Center) for their


                    measurements of the titer of C. burnetii for Q-fever, and Dr. Mitsuo Kondo (Kondo Mental


                    Clinic) for psychiatric evaluation of the patients. The authors also thank Gyoshin Ko and


                    Teruko Mizutani for their technical assistance. This work was supported in part by a


                    Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of


                    Japan (No. 16390199 to N. B.) and a grant from Japan Science and Technology Agency (to K.


                    R.).




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                    REFERENCES

                    1.   Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. (1994) The
UNCORRECTED PROOF

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UNCORRECTED PROOF

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UNCORRECTED PROOF

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                    21.   Webb SM, de Andres-Aguayo I, Rojas-Garcia R, et al. (2003) Neuromuscular


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                                                       www.molmed.org
                                                         Molecular Medicine
                                                                               MoMed-2007-00059.R2            27


                    Figure Legends

                    Figure 1.     Identification of 12 CFS-associated genes in patients with CFS. The
UNCORRECTED PROOF

                    expressions of 1072 genes were compared between 11 patients with CFS and age- and


                    sex-matched healthy controls, and 12 common genes were identified that were significantly


                    changed in CFS patients according to the paired t-test using the cyber-T stats program


                    (Bonferroni wide false positive rate = 0.05). Heatmap values represent the relative ratios of


                    gene expressions between CFS and age- and sex-matched healthy controls. Hierarchical


                    clustering was performed by the results of average linkage and distance metric of cosine θ.

                    Gene symbols, P-values, GenBank accession numbers, and names of the 12 genes are listed.


                    P-values are based on paired t-tests. Patient’s numbers indicated at the bottom of column are


                    corresponding to the numbers in Table 1.




                    Figure 2.   Relative expression of 10 marker genes in patients with CFS by microarray

                    and real-time PCR. RNA prepared from 11 patients with CFS and age- and sex-matched

                    healthy controls was subjected to TaqMan real-time PCR as described in the method section.


                    Of the 12 genes, 10 mRNA levels were measured and then normalized to GAPDH mRNA


                    expression. After the relative ratios of 10 mRNAs between CFS patients and control subjects


                    were calculated, they were compared between microarray (empty bars) and real time PCR


                    results (solid bars). Values are mean fold changes ± SD (n = 11). #P < 0.05 by the paired t-test.




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                                                        Molecular Medicine
                                                                             MoMed-2007-00059.R2           28




                    Figure 3. Expression of 9 marker genes in CFS and non-CFS cases. RNA was prepared
UNCORRECTED PROOF

                    from whole blood of 3 additionally enrolled patients with CFS and 20 patients with the chief


                    complaint of general fatigue related to other disorders, and subjected to the microarray


                    analysis. The expression patterns of 9 genes in these patients were compared with those of the


                    initially enrolled 11 patients with CFS by hierarchical cluster analysis. CFS and non-CFS


                    cases are indicated as red and yellow bars, respectively. Patient’s numbers indicated at the

                                                                                         #
                    bottom of columns are corresponding to the numbers in Table 1.           Three newly enrolled


                    patients with CFS.




                    Figure 4.   Differentiation of CFS and non-CFS cases by expression levels of 9 marker

                    genes. (A) The expressions of 9 marker genes were validated by real-time PCR, and their

                    mean values were compared in 18 newly enrolled CFS patients (indicated as “C”) with 12


                    non-CFS patients (indicated as “N”). Values are mean fold changes ± SD. #P < 0.05 by the


                    unpaired t-test. (B) The expression levels of 9 genes from 18 CFS and 12 non-CFS patients

                    were differentiated using hierarchical cluster analysis by the results of average linkage and


                    distance metric of cosine θ. CFS and non-CFS patients are indicated as red and yellow bars,

                    respectively. Patient’s numbers indicated at the bottom of columns are corresponding to the


                    numbers in Table 1.




                                                         www.molmed.org
UNCORRECTED PROOF                                                           Molecular Medicine
                                                                                                                                   MoMed-2007-00059.R2          29



                    Table 1 Clinical features of patients
                                                                                   Symptoms according to the revised CDC criteria for CFS
                    Patient Age Sex Duration      Clinical        Unexplained   Impairment   Sore     Tender   Muscle   Multijoint     Headaches   Un-          Post-
                    No.                of illness diagnosis       fatigue       in memory    throat   nodes    pain     pain                       refreshing   exertional
                                       (y)                                                                                                         sleep        malaise
                    1       41   F     12         CFS                   +           +            -      -         -            +           +             +           +
                    2       25   M     2          CFS +                 +           +            -      -         -            -           +             +           +
                                                  Adjustment
                                                  disorder
                    3       35   M     3          CFS                   +           -            -      +         -            +           +             +           +
                    4       30   F     5          CFS                   +           +            +      +         +            +           +             +           +
                    5       27   F     1          CFS                   +           +            -      -         +            +           +             +           +
                    6       25   F     7          CFS +                 +           +            +      -         -            +           +             +           +
                                                  Mood disorder
                    7       26   F     3          CFS                   +           +            -      -         +            +           +             +           +
                    8       46   F     13         CFS                   +           +            -      -         -            +           +             +           +
                    9       29   M     2          CFS +                 +           +            -      +         -            -           +             +           +
                                                  Mood disorder
                    10      30   M     1          CFS                   +           +            -      -         +            -           +             -           +
                    11      53   F     5          CFS                   +           +            -      +         -            -           +             +           +


                    Additionally enrolled patients for microarray analysis
                    12     28     F    2           CFS +              +             +            -      +         -            -           +             +           -




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UNCORRECTED PROOF                                             Molecular Medicine
                                                                                                   MoMed-2007-00059.R2   30

                                        Adjustment
                                        disorder
                    13   24   F   8     CFS               +           +            +   +   -   -           -        +         +
                    14   25   M   5     CFS +             +           +            +   -   +   +           -        +         +
                                        Mood disorder
                    15   30   F   3     Mood disorder     +           +            +   -   +   +           +        +         +
                    16   24   F   3     Somatoform        +           -            +   +   -   +           -        +         -
                                        disorder
                    17   45   F   12    Personality       +           +            -   -   -   -           -         -        +
                                        disorder
                    18   38   F   3     Mood disorder     +            -           -   -   -   +           +        +         -
                    19   39   F   1     Adjustment        +           +            +   -   +   +           +        +         -
                                        disorder
                    20   25   F   0.5   Eosinophillia     +            -           -   +   +   +           +        +         -
                    21   42   M   13    Diabetes          +            -           -   +   -   -           -        +         -
                                        mellitus
                                        type II +
                                        Hyper-
                                        creatininkinase
                                        mia
                    22   34   M   0.5   Mood disorder     +           +            -   -   +   -           -        +         +
                    23   15   M   1     Sleep disorder    +           +            -   +   -   -           -        +         +
                    24   42   F   8     Mood disorder     +           +            -   +   -   +           +        +         -
                    25   35   F   5     Anxiety           +           +            -   -   -   -           +        +         -
                                        disorder



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UNCORRECTED PROOF                                                         Molecular Medicine
                                                                                                               MoMed-2007-00059.R2   31

                    26      60   F     5          Mood disorder       +             -          +   -   -   +           +        +         -
                    27      23   F     1          Mood disorder       +             +          +   -   -   +           +        +         -
                    28      41   F     2          Mood disorder       +             -          -   +   +   -           -        +         -
                    29      30   M     4          Adjustment          +             +          +   -   +   -           +        +         +
                                                  disorder
                    30      17   F     1          Adjustment          +             -          +   -   +   +           +         -        -
                                                  disorder
                    31      46   M     7          Unexplained         +             +          +   -   +   +           +         -        +
                                                  fatigue
                    32      31   F     4          Unexplained         +             +          +   +   +   -           +        +         +
                                                  fatigue
                    33      23   F     0.5        Unexplained         +             -          +   +   -   -           -        +         +
                                                  fatigue
                    34      33   M     3          Adjustment          +             +          -   -   -   -           +        +         +
                                                  disorder


                    Additionally enrolled patients for quantitative real-time PCR
                    35     45     F    0.5         CFS                  +           +          +   +   +   +           +        +         +
                    36     13     F    0.75        CFS +                +           +          +   -   +   +           +        +         +
                                                  Adjustment
                                                  disorder
                    37      28   F     7          CFS +               +             +          +   -   +   -           -        +         +
                                                  Adjustment
                                                  disorder
                    38      31   F     2.5        CFS                 +             -          +   +   +   +           +        +         +



                                                                          www.molmed.org
UNCORRECTED PROOF                                         Molecular Medicine
                                                                                               MoMed-2007-00059.R2   32

                    39   24   F   4     CFS           +           -            +   +   +   +           +        +         +
                    40   25   M   2     CFS +         +           +            +   -   +   -           +        +         +
                                        Adjustment
                                        disorder
                    41   25   F   3     CFS +         +           +            +   -   +   -           +        +         +
                                        Adjustment
                                        disorder
                    42   35   M   10    CFS           +           +            +   -   +   +           +        +         +
                    43   27   F   10    CFS           +           +            -   -   +   +           +        +         +
                    44   29   M   3     CFS           +           +            +   -   -   -           +        +         +
                    45   41   F   15    CFS           +           +            +   -   -   +           +        +         +
                    46   45   M   7     CFS           +           +            +   +   +   +           +        +         +
                    47   46   F   0.8   CFS +         +           +            +   -   +   -           +        -         -
                                        Secondary
                                        depression
                    48   35   M   1.1   CFS + Major   +           +            -   +   -   +           -        +         +
                                        depression
                    49   53   M   6     CFS           +           +            +   -   -   +           -        +         +
                    50   26   M   4     CFS +         +           +            +   -   +   +           +        +         +
                                        Secondary
                                        depression
                    51   38   M   6     CFS           +           +            +   -   -   -           +        +         +
                    52   26   F   1     CFS           +           +            +   +   +   +           +        +         +
                    53   37   F   1     Major         +           +            -   -   +   +           -        +         +
                                        depression



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UNCORRECTED PROOF                                           Molecular Medicine
                                                                                                  MoMed-2007-00059.R2   33

                    54   48   F   1.5   Adjustment      +           +            +   -   +-   +           -        +         +
                                        disorder
                    55   31   F   5     Adjustment      +            -           -   -   -    +           +         -        +
                                        disorder
                    56   28   M   5     Major           +           +            +   -   +    +           +        +         +
                                        depression
                    57   26   M   2     Unexplained     +           +            -   -   -    -           -        +         +
                                        fatigue
                    58   72   F   5     Unexplained     +           +            -   -   +    +           +        +         +
                                        fatigue
                    59   41   F   4     Adjustment      +           +            +   +   -    +           +        +         +
                                        disorder
                    60   38   F   9     Adjustment      +            -           -   -   +    -           +         -        +
                                        disorder
                    61   33   F   7     Adjustment      +           +            -   -   -    -           +        +         +
                                        disorder
                    62   32   M   2.5   Hypo-cerebros   +            -           -   -   +    -           -        +         +
                                        pinal fluid
                    63   28   F   4     Mood disorder   +           +            -   -   -    +           +        +         +
                    64   37   M   1     Major           +           +            -   -   +    -           -        +         +
                                        depression +
                                        Sleep apnea




                                                            www.molmed.org
UNCORRECTED PROOF                                                     Molecular Medicine
                                                                                                                   MoMed-2007-00059.R2   34

                    Table 2   List of TaqMan probes and primer sets




                    Gene Symbol                 GenBank accession number   Batch ID        Slope    in      standard   curve
                                                                                           (Ct/Quantity)
                    GZMA                        M18737                     Hs00196206_m1                   -3.58
                    ATP5J2                      AF047436                   Hs00934710_m1                   -3.30
                    DBI                         BC006466                   Hs01554584_m1                   -3.69
                    HINT                        U51004                     Hs00602163_m1                   -3.19
                    KIAA0194                    D83778                     Hs00412357_m1                   -3.77
                    COX5B                       NM_001862                  Hs00426948_m1                   -3.24
                    ARHC                        L25081                     Hs00237129_m1                   -3.70
                    PSMA4                       BC005361                   Hs00160566_m1                   -3.88
                    PSMA3                       BC005265                   Hs00541061_m1                   -3.09
                    STAT5A                      L41142                     Hs00559643_m1                   -3.29
                    GAPDH                       M33197                     Hs99999905_m1                   -3.29




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UNCORRECTED PROOF
                    Molecular Medicine
UNCORRECTED PROOF




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UNCORRECTED PROOF
UNCORRECTED PROOF   Molecular Medicine




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                                                         Molecular Medicine




                    Supplementary Table 1      Laboratory data of patients
                    Patient Age Sex BMI Laboratory data
                    No.                        RBCA       PLTB     WBCC      PMND   LymphE   MonoF   EoG   BasoH
UNCORRECTED PROOF

                    1       41    F     20.8    4.48       283      5300     51.3    41.4     4.2    2.5    0.6
                    2       25    M     17.8    5.40       246      6800     51.8    38.9     5.5    3.4    0.4
                    3       35    M     23.5    4.77       193      3900     55.4    33.4     4.8    5.9    0.5
                    4       30    F     19.7    4.55       199      8400     77.8    16.9     4.1    0.8    0.4
                    5       27    F     20.3    4.51       197      6100     75.0    19.6     4.8    0.3    0.3
                    6       25    F     17.2    N/D       N/D       N/D      N/D     N/D     N/D     N/D   N/D
                    7       26    F     18.6    4.02       264      4500     63.9    26.9     4.0    2.6    2.6
                    8       46    F     18.0    4.37       138      5500     68.6    25.0     3.1    3.1    0.2
                    9       29    M     22.8    5.00       222      6300     65.8    28.4     4.3    1.3    0.2
                    10      30    M     22.3    4.65       171      4300     60.8    32.6     4.0    2.1    0.5
                    11      53    F     21.8    4.23       228      5300     53.6    39.2     4.5    2.3    0.4


                    Additionally enrolled patients for microarray analysis
                    12      28    F     17.4    4.17       211      2800     54.5    37.2    N/D     N/D   N/D
                    13      24    F     22.2    4.09       232      3900     65.2    27.6     2.8    4.1    0.8
                    14      25    M     20.2    4.89       238      8800     68.2    25.5     4.8    0.9    0.6
                    15      30    F     16.6    4.29       229      7300     56.2    36.8     4.1    2.5    0.4
                    16      24    F     19.0    4.29       223      5600     36.9    55.3     1.0    3.0    0
                    17      45    F     23.1    N/D       N/D       9900     76.5    N/D     N/D     0.7   N/D
                    18      38    F     20.6    N/D       N/D       N/D      N/D     N/D     N/D     N/D   N/D
                    19      39    F     21.1    3.97       340      9000     73.2    16.4     4.7    4.8    0.9
                    20      25    F     19.8    3.87       202      5000     51.1    35.5     3.6    7.8    2.2
                    21      42    M     22.0    4.48      197       7500     48.6    40.5     6.0    4.0    0
                    22      34    M     24.3    4.91      292       6200     65.3    25.6     4.7    2.8    1.6
                    23      15    M     20.6    5.02      245       5700     44.0    46.7     4.9    3.5    0.9
                    24      42    F     22.2    N/D       N/D       N/D      N/D     N/D     N/D     N/D   N/D
                    25      35    F     18.7    4.71       275      4200     59.8    36.1     3.1    0.5    0.5
                    26      60    F     22.6    4.57       181      7700     62.6    32.3     3.7    1.0    0.4
                    27      23    F     40.6    4.37       245      7500     68.0    27.2     4.0    0.7    0.1
                    28      41    F     16.6    4.57       296      4100     69.4    24.8     4.6    0.5    0.7
                    29      30    M     20.2    4.52       277      5100     58.1    27.6     5.3    8.2    0.8
                    30      17    F     26.1     4.5       306      8300     50.0    42.8     8.0    6.0    1.0
                    31      46    M     23.5    4.65       200      3500     62.0    27.2     5.7    4.5    0.6
                    32      31    F     18.7    4.75      240       7000     60.7    33.5    N/D     N/D   N/D




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                                                            Molecular Medicine



                    33      23    F     25.6      4.64       266      5600   63.0        28.4        4.3   3.9   0.4
                    34      33    M     21.5      5.93       260      6500   66.9        22.8        5.6   4.2   0.5


                    Additionally enrolled patients for quantitative real-time PCR
UNCORRECTED PROOF

                    35      45    F     15.5      3.53        69      5500   51.6        40.1        8.0   2.0   0
                    36      25    M     20.2      3.73       209      4900   56.1        38.2        3.3   1.8   0.6
                    37      31    F     16.9      4.26       253      5100   63.4        26.2        5.9   3.9   0.6
                    38      24    F     17.3      4.06       203      5400   62.1        31.3        3.7   2.2   0.7
                    39      13    F     21.5      4.82       194      4500   57.7        33.1        7.2   1.8   0.2
                    40      28    F     22.0      4.93       209     10800   68.4        23.7        5.4   2.1   0.4
                    41      29    M     18.4      4.92       205      4500   50.9        37.9        4.5   5.6   1.1
                    42      41    F     21.7      3.48       192      3200   60.3        30.2        4.8   4.1   0.6
                    43      25    F     19.1      3.86       184      5100   62.0        29.0        3.3   4.5   1.2
                    44      35    M     18.6      5.03       212      4600   58.7        28.1        3.9   8.4   0.9
                    45      27    F     21.4      4.26       192      4700   57.7        33.5        4.1   4.3   0.4
                    46      45    M     23.1      5.23       282      5300   61.0        25.3        7.7   5.6   0.4
                    47      46    F     23.2      4.31       186      5000   67.9        24.7        3.8   3.2   0.4
                    48      53    M     24.8      5.52       209      5400   61.7        32.5        4.5   0.9   0.4
                    49      26    M     26.8      4.97       233      4200   65.4        25.2        5.4   3.3   0.7
                    50      38    M     20.7      4.86       180      5200   59.5        32.4        5.6   2.1   0.4
                    51      35    M     22.7      4.41       247      5300   46.7        42.1        5.6   5.4   0.2
                    52      26    F     16.9      4.06       284      3900   53.3        39.0        5.1   1.8   0.8
                    53      37    F     22.5      4.36       210      3900   44.9        40.4        7.2   6.7   0.8
                    54      48    F     20.3      4.69       298      5700   63.9        29.5        3.8   2.6   0.2
                    55      26    M     21.6      5.67       220      5000   50.3        42.7        5.4   1.2   0.4
                    56      72    F     24.2      3.89       229      7500   66.0        28.1        3.3   2.3   0.3
                    57      28    M     20.9      5.56       218      8300   62.1        28.6        4.8   4.3   0.2
                    58      33    F     18.2      4.01       190      4900   53.0        39.2        3.9   3.1   0.8
                    59      41    F     21.3      3.58       248      5300   57.8        35.4        5.1   1.5   0.2
                    60      38    F     19.7      4.71       107      3400   51.3        43.4        4.1   0.9   0.3
                    61      31    F     21.5      3.99       200      5100   61.4        30.9        5.7   1.4   0.6
                    62      32    M     20.3      5.31       234      5800   53.2        41.1        2.9   1.9   0.9
                    63      28    F     19.2      4.47       214      5200   72.6        21.5        4.1   1.0   0.8
                    64      37    M     29.3      4.93       266      8800   55.4        33.6        5.0   5.4   0.6
                    A
                     RBC, erythrocytes (x 106/mm3); BPLT, thrombocytes (x 103/mm3); CWBC,

                    leukocytes/mm3;       D
                                              PMN,         neutrophils/WBC       (%);      E
                                                                                               Lymph,
                                                     F                                           G
                    lymphocytes/WBC        (%);          Mono,     monocytes/WBC        (%);      Eo,




                                                             www.molmed.org
                                                    Molecular Medicine



                    eosinophils/WBC (%); HBaso, basophils/WBC (%);

                    N/D, not determined
UNCORRECTED PROOF




                                                     www.molmed.org
                                                                                                                                                       1                                            2                                            3




                                                                                                                                                                                                                                                              UNCORRECTED PROOF
                                                                                                                                 CFS                                             CFS                                          CFS
                              Probe ID                                                                                                                Cy5            Cy3                           Cy5            Cy3                           Cy5
                     Systematic          GenBank     Symbol2   Name                                                             Ratio           Patient        Control        Ratio          Patient         Control        Ratio          Patient
                     <346>5T4            Z29083      5T4       H.sapiens 5T4 gene for 5T4 Oncofetal antigen                          0.82468563       26582.53      32233.53       0.8283697       16415.28       19816.37       0.8185312       49995.55
                     <376>AADAC          L32179      AADAC     Human arylacetamide deacetylase mRNA                                   0.9661829         127.14         131.59 0.39672217                30.5          76.88
                     <1046>AANAT         U40347      AANAT     Human serotonin N-acetyltransferase mRNA, complete cds                  1.281873          3134         2444.86      1.4208754         4606.89        3242.29       1.543924         7740.71
                     <486>ABCA1          AJ012376    ABCA1     Homo sapiens mRNA for ATP-binding cassette transporter-1 (ABC-1)       0.6302882         113.08         179.41 0.78014886              325.01          416.6      0.3623763           81.31
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                     <1152>ABCA2         U18235      ABCA2                                                                           cds
                                                               Human ATP-binding cassette protein (ABC2) mRNA HFBCD04 clone, partial 1.281212              304.89       237.97         2.2050097        362.68       164.48
                     <708>ABCA3          U78735      ABCA3     Human ABC3 mRNA, complete cds                                            1.1685586        54.56          46.69
                     <779>ABCA4          U88667      ABCA4     Human ATP binding cassette transporter (ABCR) mRNA, complete cds         1.4912049        1470          985.78        1.078978       1288.44        1194.13       1.0043156        1708.15
                     <1208>ABCA8         AB020629    ABCA8     Homo sapiens mRNA for KIAA0822 protein, complete cds                     1.9931512     19661.14        9864.35       1.4977642      28177.17       18812.82       1.4833399       45303.44
                     <269>ABCB1          M14758      ABCB1     Homo sapiens P-glycoprotein (PGY1) mRNA (MDR1)                           1.6052847      4275.05        2663.11       1.3012205       5354.47        4114.96       0.8949641        9443.76
                     <657>ABCB10         U18237      ABCB10    Human ATP-binding cassette protein mRNA 06B09 clone, partial cds        0.98042285      1014.62        1034.88      0.39366078        329.25         836.38      0.80588883        2784.37
                     <616>ABCB11         AF091582    ABCB11    Homo sapiens bile salt export pump (BSEP) mRNA, complete cds             1.7851515       144.99          81.22     0.108126424         12.76         118.01       0.8809934         163.53
                     <909>ABCB2          X57522      ABCB2     H.sapiens RING4 cDNA                                                     0.4073754     30857.13       75746.18      0.85192376      58222.04       68341.84       1.0743388       68623.35

                     <414>ABCB3          NM_000544   ABCB3     Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 3 0.58315915              516.16       885.11         0.8837771        661.79       748.82
                     <270>ABCB4          M23234      ABCB4     Human membrane glycoprotein P (mdr3) mRNA, complete cds            0.96547383            7605.52         7877.5         0.6860313     1170.04        1705.52         0.8776653        498.47
                     <880>ABCB6          AF070598    ABCB6     Homo sapiens clone 24410 ABC transporter mRNA, partial cds          1.1919404             475.62         399.03         1.7368027     1761.83        1014.41         0.9138552        773.88
                     <153>ABCB7          AF038950    ABCB7     Homo sapiens ATP binding cassette transporter mRNA, complete cds    1.0907798            1817.73        1666.45         1.0660722     3733.79        3502.38         1.2137651        4217.3
                                                               Homo sapiens ATP-binding cassette protein M-ABC1 mRNA, nuclear gene
                     <939>ABCB8          AF047690    ABCB8               encoding mitochondrial protein, complete cds              0.5537899                92.35       166.76         1.365355         319.93       234.32         0.8398882     1097.02

                     <752>ABCC1          L05628      ABCC1     Human multidrug resistance-associated protein (MRP) mRNA, complete cds
                                                                                                                                   0.90677726           1188.25        1310.41     0.93322104        1102.47        1181.36         0.8260399     1113.89
                                                               Human canalicular multispecific organic anion transporter (cMOAT) mRNA,
                     <530>ABCC2          U63970      ABCC2                complete cds                                                  1.2428247          174.94       140.76         0.7585105         341.8       450.62     0.37003654            80.05
                                                               Homo sapiens canalicular multispecific organic anion transporter 2 (CMOAT2)
                     <477>ABCC3          AF083552    ABCC3                mRNA, complete cds                                            0.8786711       1062.99        1209.77         1.0935366        938.67       858.38         1.4105465     2359.52

                     <155>ABCC4          AF071202    ABCC4     Homo sapiens ABC transporter MOAT-B (MOAT-B) mRNA, complete cds 0.89412165                  812.39       908.59         0.6251294        555.29       888.28         0.3517467        191.41
                     <127>ABCC5          AB005659    ABCC5     Homo sapiens SMRP mRNA, complete cds                               0.77427864               399.28       515.68                                                      1.1936091        2578.9
                     <1123>ABCC6         AF076622    ABCC6     Homo sapiens MRP6 (MRP6) mRNA, complete cds                          13.97376                47.93         3.43         2.4057357        141.77        58.93
                     <698>ABCC8          U63421      ABCC8     Human sulfonylurea receptor (SUR1) mRNA, complete cds.              3.4846232               168.83        48.45
                                                               Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 9
                     <498>ABCC9          NM_005691   ABCC9                (ABCC9), mRNA                                             1.190869               399.87       335.78     0.65391845           330.51       505.43         0.8522669        233.47
                     <129>ABCD2          AJ000327    ABCD2     Homo sapiens mRNA for adrenoleukodystrophy related protein (ALDR). 0.86739737               653.61       753.53         0.9379554     1348.02        1437.19     0.88453656           621.44
Molecular Medicine




                     <1235>ABCD3         M81182      ABCD3     Homo sapiens peroxisomal 70 kD membrane protein mRNA, complete cds
                                                                                                                                0.96493876              4991.03        5172.38         0.881302      5530.54        6275.42         0.970598      4009.87
                     <387>ABCE1          X74987      ABCE1     H.sapiens mRNA for 2'-5' oligoadenylate binding protein                 1.5619996        5407.33         3461.8         0.8555613     6261.34         7318.4         0.9373272    15237.81

                     <814>ABCF1          AF027302    ABCF1     Homo sapiens TNF-alpha stimulated ABC protein (ABC50) mRNA, complete cds
                                                                                                                                 0.84540296             1616.14        1911.68     0.59163773           446.58       754.82         0.6605788        844.18
                     <924>ABCF2          AF091073    ABCF2     Homo sapiens clone 203 ABC transporter mRNA, complete cds                1.0710317       1952.78        1823.27          1.074721     1949.92        1814.35         1.1784067     4072.55
                     <690>ABCG1          U34919      ABCG1     Human white homolog (white) mRNA, complete cds                          0.58146095        365.14         627.97         0.4467824      647.83        1449.99         0.5244734      778.67
                                                               Homo sapiens placenta-specific ATP-binding cassette transporter (ABCP) mRNA,
                     <176>ABCG2          AF103796    ABCG2                   complete cds                                                0.966169       3002.37         3107.5         1.295151      5376.56         4151.3         1.3780384    12920.57
                     <1056>ABL1          M14752      ABL1      V-abl Abelson murine leukemia viral oncogene homolog 1                   2.0948482            61.4        29.31                                                      0.7382431        285.39
                     <713>ABL2           M35296      ABL2      Human tyrosine kinase arg gene mRNA                                       1.427806          199.85       139.97         0.8592585        164.78       191.77
                                                               Homo sapiens dipeptidyl carboxypeptidase 1 (angiotensin I converting enzyme)
                     <1398>ACE           NM_000789   ACE                   (ACE)                                                         1.298575          1175.6        905.3         1.859806      3588.57        1929.54         1.5334356     3308.74
                                                               Human TGF-b superfamily receptor type I mRNA; activin receptor-like kinase 1
                     <938>ACVRL1         L17075      ACVRL1                  (ACVRL1; ALK1)                                             0.6893663          422.94       613.52         0.3498439        173.68       496.45         1.0061438        1061.2

                                                               Homo sapiens snake venom-like protease (cSVP) mRNA, A disintegrin and
                     <302>ADAM17         U92649      ADAM17                                                                            1.3750882
                                                                          metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) 4864.76        3537.78         1.2099768     5764.97        4764.53         1.0634949        3703.1

                                                               Homo sapiens adenylate cyclase 1 (ADCY1); Human fetal brain adenylyl cyclase
                     <1393>ADCY1         L05500      ADCY1                mRNA, 3' end
                     <1360>ADCY2       AF070583    ADCY2         Homo sapiens clone 24648 adenylyl cyclase mRNA, partial cds            0.52770066      83.63     158.48                                        1.7733462     256.55




                                                                                                                                                                                                                                       UNCORRECTED PROOF
                     <1358>ADCY3       NM_004036   ADCY3         Homo sapiens adenylate cyclase 3 (ADCY3)                                0.9153301    2942.64    3214.84    1.3385147     2452.44    1832.21    1.0042719    7468.72
                     <1356>ADCY6       AF250226    ADCY6         Homo sapiens adenylyl cyclase type VI mRNA                             0.79294884    3768.18    4752.11    0.6768964      949.97    1403.42    0.8426859    2899.64
                     <1289>ADCY7       NM_001114   ADCY7         Homo sapiens adenylate cyclase 7 (ADCY7)                               0.93176603    9566.73   10267.31   0.79218477     9076.14    11457.1   0.94750434   10063.32
                     <1309>ADCY8       Z35309      ADCY8         H.sapiens mRNA for adenylyl cyclase                                     1.5033292     720.26     479.11    1.1460236      742.44     647.84    1.3249396     707.69
                     <1290>ADCY9       NM_001116   ADCY9         Homo sapiens adenylate cyclase 9 (ADCY9)                                0.8122153    1792.08    2206.41   0.80049825     1150.38    1437.08    1.0224912    1879.84

                     <1260>ADCYAP1     NM_001117   ADCYAP1       Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) (ADCYAP1)                                                                  1.216524      659.21
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                                                             Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
                     <1379>ADCYAP1R1   NM_001118   ADCYAP1R1               (ADCYAP1R1)                                                 0.70860046      218.83     308.82    1.4417642      247.45     171.63   1.4935173      446.95
                     <1177>ADH1        M12963      ADH1      Human class I alcohol dehydrogenase (ADH1) alpha subunit mRNA              1.5230697      163.73      107.5    2.2421777      234.33     104.51
                     <227>ADH2         M21692      ADH2      Human class I alcohol dehydrogenase (ADH2) beta-1 subunit mRNA              0.821561     1274.43    1551.23   0.47294945     1151.14    2433.96   0.6619257     2347.93

                     <1057>ADH3        M12272      ADH3          Homo sapiens alcohol dehydrogenase class I gamma subunit (ADH3) mRNA7.516129           27.96       3.72                                       0.8814444      413.75
                     <228>ADH4         M15943      ADH4          Human class II alchohol dehydrogenase (ADH4) pi subunit mRNA         0.7770175        187.37     241.14    0.6216623      239.34       385
                     <229>ADH5         M29872      ADH5          Human alcohol dehydrogenase class III (ADH5) mRNA                     2.626805      12103.03    4607.51    1.7070508    23761.14   13919.41   1.3659952    40934.57
                     <632>ADH6         NM_000672   ADH6          Homo sapiens alcohol dehydrogenase 6 (class V) (ADH6) mRNA           1.3038776         49.43      37.91
                     <564>ADPRT        M18112      ADPRT         Human poly(ADP-ribose) polymerase mRNA (ADPRT), PARP                0.95607406      14022.26    14666.5     1.683587    76850.81   45647.07    0.8393498   23767.29
                     <163>ADPRTL1      AF057160    ADPRTL1       ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1   0.5750623        4357.5    7577.44   0.47112912     4105.24    8713.62   0.46654436    6271.98
                     <991>AFG3L2       NM_006796   AFG3L2        AFG3 (ATPase family gene 3, yeast)-like 2                            1.0438839        12256    11740.77    1.3279562    18463.73   13903.87    0.9753672   23411.28
                     <1332>AGTR1       M87290      AGTR1         Human angiotensin II type 1 receptor mRNA                           0.73764896         140.5     190.47    1.2688185      207.16     163.27
                     <1347>AGTR1B      X65699      AGTR1B        H.sapiens mRNA for angiotensin II receptor                           1.5530243        2953.2    1901.58     1.461303     5666.48    3877.69    1.1506997    8882.47
                     <1321>AGTR2       NM_000686   AGTR2         Homo sapiens angiotensin receptor 2 (AGTR2)                          1.5445592        594.47     384.88    1.6897374      489.01      289.4    1.4525867     763.16
                     <1439>AGTRL1      NM_005161   AGTRL1        Homo sapiens angiotensin receptor-like 1 (AGTRL1)                    1.4178787        320.71     226.19    1.3276998       348.8     262.71    3.2251482     184.93
                     <1318>AGTRL2      NM_005162   AGTRL2        Homo sapiens angiotensin receptor-like 2 (AGTRL2)                    0.8743982       6474.63    7404.67   0.84513503     9438.13    11167.6   0.88072217   36749.17
                     <1207>AHR         L19872      AHR           Human AH-receptor mRNA, complete cds                                 0.6428784        647.43    1007.08     1.054955     7217.38    6841.41    1.1670619    6933.69
                                                                 Homo sapiens immunophilin homolog ARA9 mRNA; aryl hydrocarbon receptor-
                     <1087>AIP         U78521      AIP                      interacting protein                                      0.99828666       2773.43    2778.19    1.7674624     2450.41     1386.4   0.6403233     5404.54
                     <1273>AKAP1       NM_003488   AKAP1         Homo sapiens A kinase (PRKA) anchor protein 1 (AKAP1)                1.0208435        1272.9    1246.91    1.4334913     4182.77    2917.89    0.7698112   15368.41
                     <1316>AKAP10      NM_007202   AKAP10        Homo sapiens A kinase (PRKA) anchor protein 10 (AKAP10)              0.9168752       3169.39    3456.73    1.0331743     3555.69    3441.52   0.78886765   13141.92
                                                                 A kinase (PRKA) anchor protein 11 (AKAP11); Homo sapiens mRNA for KIAA0629
                     <1268>AKAP11      AB014529    AKAP11                      protein, partial cds                                   1.2239121       10389.9    8489.09    1.0736177    39174.87   36488.66   1.2774324    32559.85
                     <1301>AKAP12      NM_005100   AKAP12        Homo sapiens A kinase (PRKA) anchor protein (gravin) 12 (AKAP12)     0.5020158        282.65     563.03   0.29225707      568.25    1944.35     0.877357    3090.06
                     <1317>AKAP2       NM_007203   AKAP2         Homo sapiens A kinase (PRKA) anchor protein 2 (AKAP2)                0.6092728        4144.2    6801.88    1.2173772     7557.94    6208.38   0.99113405   25060.19
                     <1310>AKAP3       NM_006422   AKAP3         Homo sapiens A kinase (PRKA) anchor protein 3 (AKAP3)                0.9590121       2394.73    2497.08    1.1265845     2730.92    2424.07    1.3601494     3320.9
                     <1274>AKAP4       NM_003886   AKAP4         Homo sapiens A kinase (PRKA) anchor protein 4 (AKAP4)                1.8879979        473.17     250.62    1.6051137      477.73     297.63   0.03673574      14.36
                     <1368>AKAP5       NM_004857   AKAP5         Homo sapiens A kinase (PRKA) anchor protein 5 (AKAP5)                1.5590241        633.26     406.19   0.61911976       236.9     382.64
                     <1311>AKAP6       NM_004274   AKAP6         Homo sapiens A kinase (PRKA) anchor protein 6 (AKAP6)                1.6593719      12633.81    7613.61     1.884132    12216.41    6483.84   0.95296705    12813.3
Molecular Medicine




                     <1325>AKAP7       NM_016377   AKAP7         Homo sapiens A kinase (PRKA) anchor protein 7 (AKAP7)                1.0865396       2057.33    1893.47     0.812842      974.24    1198.56    1.2566637    1792.48
                     <1304>AKAP8       NM_005858   AKAP8         Homo sapiens A kinase (PRKA) anchor protein 8 (AKAP8)                1.2259374       5661.82    4618.36    0.9907886     4165.82    4204.55    1.1083598    4412.99
                     <1307>AKAP9       NM_005751   AKAP9         Homo sapiens A kinase (PRKA) anchor protein (yotiao) 9 (AKAP9)       1.4250412        588.77     413.16

                     <1339>AKR1B1      NM_001628   AKR1B1        Homo sapiens aldo-keto reductase family 1, member B1 (aldose reductase)1.3558102    12257.88      9041     1.4893034    50311.96   33782.21   1.4829528    41219.34
                     <1336>AKR1B10     AF052577    AKR1B10       Homo sapiens aldo-keto reductase mRNA                                  0.88386506     325.28     368.02    0.7437776      492.47     662.12

                     <1434>AKR1B11     NM_004812   AKR1B11       Homo sapiens aldo-keto reductase family 1, member B11 (aldose reductase-like)
                                                                                                                                       1.7161835       213.15      124.2    2.3579967      611.57     259.36   0.99043596     588.21
                     <791>AKT1         M63167      AKT1          Human rac protein kinase alpha mRNA (akt1), complete cds               0.79591304    4654.46    5847.95     0.7137049    8668.56   12145.86    1.0771917     7870.9
                     <1058>AKT2        M95936      AKT2          Human protein-serine/threonine (AKT2) mRNA; rac protein kinase beta     0.6742311     531.22     787.89   0.047403887      17.73     374.02   0.64579743    1292.88
                     <455>ALDH1        AF003341    ALDH1         Homo sapiens aldehyde dehydrogenase 1 (ALDH1) mRNA                      0.5733465    3123.54    5447.91     0.3142829    4927.66   15679.06     1.505925   23050.38
                     <265>ALDH10       U46689      ALDH10        Human microsomal aldehyde dehydrogenase (ALD10) mRNA                   0.88327974    5791.25    6556.53     1.1597813   12469.61   10751.69    1.0221999   19917.39

                     <941>ALDH2        NM_000690   ALDH2         Homo sapiens aldehyde dehydrogenase 2, mitochondrial (ALDH2) mRNA 0.5146548           358.56      696.7    1.0491385     5933.98    5656.05   1.0733486    15649.52
                     <1059>ALDH3       M74542      ALDH3         Human aldehyde dehydrogenase type III (ALDHIII) mRNA                    1.3019997    1257.94     966.16    1.1280807     1779.57    1577.52   1.1576747     8636.16
                                                                 Homo sapiens aldehyde dehydrogenase 4 (glutamate gamma-semialdehyde
                     <1129>ALDH4       NM_003748   ALDH4                                                                             0.9047711
                                                                          dehydrogenase; pyrroline-5-carboxylate dehydrogenase) (ALDH4) mRNA           141.85     156.78       1.9676      710.52     361.11    1.558097     1053.18
                     <942>ALDH5      NM_000692   ALDH5     Homo sapiens aldehyde dehydrogenase 5 (ALDH5), mRNA                    1.1464777      156.07     136.13                                       0.8845002     277.68




                                                                                                                                                                                                                                UNCORRECTED PROOF
                     <482>ALDH5A1    Y11192      ALDH5A1   H.sapiens mRNA for NAD+-dependent succinic semialdehyde dehydrogenase
                                                                                                                              1.2517213         1367.08    1092.16    1.460472      2865.3     1961.9    0.7004507    1774.76
                     <412>ALDH6      U07919      ALDH6     Human aldehyde dehydrogenase 6 mRNA, complete cds                      1.3106712      498.54     380.37   0.7470888      669.16     895.69    0.7352589      275.7
                     <1223>ALDH7     U10868      ALDH7     Human aldehyde dehydrogenase ALDH7 mRNA                                0.9135903      666.72     729.78   1.2109733     1169.34     965.62    1.4306281    1184.56
                     <673>ALDH8      U37519      ALDH8     Human aldehyde dehydrogenase (ALDH8) mRNA                              1.1223238     2368.44     2110.3   0.8633953     3329.58    3856.38    1.1245165    3531.69
                     <199>ALDH9      U34252      ALDH9     Human gamma-aminobutyraldehyde dehydrogenase mRNA                      1.4911691    12682.08    8504.79   0.8847069    12957.09   14645.63    0.6947108   33565.07
                                                           Homo sapiens AP1S1adaptor-related protein complex 1, sigma 1 subunit
                     <1432>AP1S1     NM_001283   AP1S1
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                                                                     (AP1S1)

                     <1343>AP1S2     NM_003916   AP1S2     Homo sapiens adaptor-related protein complex 1, sigma 2 subunit (AP1S2)1.2757875       5904     4627.73   1.3939022    44476.06   31907.59    1.4785281   39300.33

                     <123>APAF1      AF013263    APAF1     Homo sapiens apoptotic protease activating factor 1 (Apaf-1) mRNA, complete cds
                                                                                                                                   0.5130777    4515.33    8800.48   0.5534187     6776.75   12245.25   0.66044337   17068.69
                     <249>APC        M74088      APC       adenomatous polyposis coli protein (APC protein); DP2.5                0.7759956    14979.71   19303.86   0.7854906    12201.74   15533.91     0.805152   30121.99
                                                           Homo sapiens mRNA for heat shock protein apg-1; Heat shock protein (hsp110
                     <183>APG-1      AB023421    APG-1                family)                                                     1.9931262     1667.25      836.5   2.7954342     6492.06    2322.38     2.589681    7887.78
                     <420>API1       U45879      API1      Human inhibitor of apoptosis protein 2 mRNA; Apoptosis inhibitor 1     1.1820182     6714.17    5680.26   0.8380132    13062.38   15587.32   0.80658114   12460.13
                     <419>API2       U45878      API2      Human inhibitor of apoptosis protein 1 mRNA; Apoptosis inhibitor 2    0.90164775      9286.8   10299.81    1.074773     14353.4   13354.82    1.0146095   17593.52
                                                           ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector
                     <644>APT6M8     NM_005765   APT6M8                 associated protein M8-9                                  0.96493477     9330.63     9669.7   0.6762842     12041.7   17805.68   0.58775115   13205.74
                                                           Homo sapiens v-raf murine sarcoma 3611 viral oncogene homolog 1 (ARAF1),
                     <943>ARAF1      NM_001654   ARAF1                 mRNA.                                                       1.033682     2604.92    2520.04   1.6910911    14889.77    8804.83    1.2120063   34642.27
                     <977>ARD1       X77588      ARD1      H.sapiens TE2 mRNA for ARD-1 N-acetyltransferase homologue            1.308017       1933.55    1478.23   1.9534863     3519.85    1801.83    1.2031636   23883.71
                                                           Homo sapiens RHOA proto-oncogene multi-drug-resistance protein mRNA, 3'
                     <1193>ARHA      L09159      ARHA                  end.; Ras homolog gene family, member A                0.86367905       46216.18   53510.83   0.6344186    40789.01   64293.53   0.76602846   48930.04
                     <1118>ARHB      X06820      ARHB      H.sapiens rhoB gene mRNA; Ras homolog gene family, member B         0.8766083        6482.72    7395.23   0.57054657     3093.8    5422.52    0.9290103    4326.15
                                                           Homo sapiens GTPase (rhoC) mRNA, complete cds; Ras homolog gene family,
                     <1124>ARHC      L25081      ARHC                  member C                                                  1.289663       3625.32    2811.06   1.5537252     5477.27    3525.25     1.452623   21837.79

                     <417>ARHE       X95282      ARHE      H.sapiens mRNA for Rho8 protein; Ras homolog gene family, member E     1.1857687      326.62     275.45   0.6902863      284.75     412.51    1.4998386     325.21

                     <908>ARHG       X61587      ARHG      H.sapiens rhoG mRNA for GTPase; Ras homolog gene family, member G (rho G)
                                                                                                                              0.8495391         9151.15    10771.9   1.0113069    18357.86   18152.61    1.0327561   38008.17
                     <952>ARHGAP1    U02570      ARHGAP1   Human CDC42 GTPase-activating protein mRNA, partial cds                0.56510025    9392.87    16621.6   0.9751425    19615.02   20115.03     1.152654   22534.93
                     <1163>ARHGAP4   X78817      ARHGAP4   H.sapiens partial C1 mRNA; Rho GTPase activating protein 4              1.0867256     1320.1    1214.75    0.938951     3018.69    3214.96    0.9346401    5695.22

                     <393>ARHGAP5    U17032      ARHGAP5   Human p190-B (p190-B) mRNA, complete cds; Rho GTPase activating protein 5
                                                                                                                                0.730392         634.55     868.78   0.5576476     1290.43    2314.06    0.5804365    1662.26

                                                           Homo sapiens GTPase-activating protein 6 isoform 4 (ARHGAP6) mRNA,
                     <185>ARHGAP6    AF177663    ARHGAP6                                                                           1.0912666
                                                                     alternatively spliced, complete cds; Rho GTPase activating protein 6        932.04     854.09   0.33855549     327.61     967.67    0.3736084      237.6

                     <1018>ARHGAP8   NM_015366   ARHGAP8   Homo sapiens Rho GTPase activating protein 8 (ARHGAP8), mRNA        1.0204072        6386.28    6258.56   1.5033026     8061.34    5362.42    1.8058276   14317.54
                     <1131>ARHGDIA   X69550      ARHGDIA   H.sapiens mRNA for rho GDP-dissociation Inhibitor 1                  1.139834       14719.93    12914.1   0.8050225     7381.38    9169.16    0.8691601    6854.84
Molecular Medicine




                     <485>ARHGDIB    L20688      ARHGDIB   Human GDP-dissociation inhibitor protein (Ly-GDI) mRNA, D4-GDI      1.0936512       68168.56   62331.17   0.8570452    55102.46   64293.53     1.256328   80028.72
                                                           Homo sapiens GDI-dissociation inhibitor RhoGDIgamma mRNA, complete cds;
                     <1055>ARHGDIG   U82532      ARHGDIG              Rho GDP dissociation inhibitor (GDI) gamma              0.48312643          49.82     103.12                                       1.3795332     339.31
                                                           Human guanine nucleotide exchange factor p115-RhoGEF mRNA, partial cds;
                     <1053>ARHGEF1   U64105      ARHGEF1             Rho guanine nucleotide exchange factor (GEF) 1            0.7214297        1271.96    1763.11   1.0564935      2751.5    2604.37   0.72195333   26068.12

                     <995>ARHH       Z35227      ARHH      H.sapiens TTF mRNA for small G protein; Ras homolog gene family, member H
                                                                                                                                1.0010722        5798.4    5792.19    1.615614    16751.09   10368.25    1.0318286     15435
                                                           Homo sapiens putative tumor supressor NOEY2 mRNA; Ras homolog gene
                     <342>ARHI       U96750      ARHI                family, member I                                        0.9114459           444.02     487.16   0.35515755      88.04     247.89   0.63173795      79.46
                                                           Homo sapiens mRNA for BMAL1a; aryl hydrocarbon receptor nuclear translocator-
                     <110>ARNTL      D89722      ARNTL                    like                                                    0.6205839     5190.34    8363.64   0.48783213   10296.97   21107.61    0.8785939   29933.07
                                                           Homo sapiens (clone 179 or 217) hydroxyindole-O-methyltransferase (HIOMT)
                     <1189>ASMT      M83779      ASMT                    mRNA, complete cds                                      0.55665493       41.07      73.78   0.79615617     142.09     178.47   0.85103256     318.55
                     <834>ASNA1      AF047469    ASNA1     ArsA (bacterial) arsenite transporter, ATP-binding, homolog 1          0.6863099      890.24    1297.14    0.4660493     703.11    1508.66    0.8403406    2651.72
                     <832>ATF1       NM_005171   ATF1      Homo sapiens activating transcription factor 1 (ATF1)                  0.7377044     1748.78    2370.57   0.30222964      550.2    1820.47   0.55393755     986.38

                     <1264>ATF2      M31630      ATF2      Human cyclic AMP response element-binding protein (HB16) mRNA, 3' end.85322785
                                                                                                                               0                1047.03    1227.14   0.6020714     1234.18    2049.89   0.71985024    3754.71
                     <1361>ATF3      L19871      ATF3      Human activating transcription factor 3 (ATF3) mRNA                    0.26371762      500.9    1899.38                                       0.6974396     185.77
                                                            Homo sapiens activating transcription factor 4 (tax-responsive enhancer element
                     <1380>ATF4      NM_001675   ATF4                     B67) (ATF4)                                                  1.1105398    1045.44     941.38   0.93280864    3209.58    3440.77   1.1422998     7711.78




                                                                                                                                                                                                                                     UNCORRECTED PROOF
                     <1357>ATF5      NM_012068   ATF5       Homo sapiens activating transcription factor 5 (ATF5)                     0.56199515     416.77     741.59    1.8134184    2006.91     1106.7    1.3991268   13151.19
                     <1320>ATF6      NM_007348   ATF6       Homo sapiens activating transcription factor 6 (ATF6)                      0.7974356    4790.77    6007.72   0.42397025    3962.99    9347.33     0.644865    6158.66
                     <1312>ATF7      NM_006856   ATF7       Homo sapiens activating transcription factor 7 (ATF7)                      0.8230142     425.63     517.16    1.0961044      968.2     883.31    1.2580768    1360.22
                     <201>ATM        U33841      ATM        Human ataxia telangiectasia (ATM) mRNA                                    0.82990116    2795.63    3368.63    0.5002177     4388.3    8772.78     0.586791    6828.61
                     <1680>ATP10D    AB040920    ATP10D     ATPase, Class V, type 10D                                                 0.77155554    4853.37    6290.37   0.91524637    7083.65    7739.61    1.1286441   12730.62
                     <1021>ATP1A1    U16798      ATP1A1     ATPase, Na+/K+ transporting, alpha 1 polypeptide                           0.7948863    2236.19    2813.22    0.9545396    5967.39    6251.59   0.69595474   15494.11
www.molmed.org



                     <350>ATP1A2     NM_000702   ATP1A2     ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide                       1.0143762     190.51     187.81
                     <944>ATP1A3     NM_000703   ATP1A3     ATPase, Na+/K+ transporting, alpha 3 polypeptide                           0.6750216    3347.83    4959.59    1.0422554     2574.6    2470.22   1.0834684     5249.48
                     <496>ATP1AL1    U02076      ATP1AL1    ATPase, Na+/K+ transporting, alpha polypeptide-like 1                      1.1463894     642.62     560.56     1.361008     425.56     312.68
                     <691>ATP1B2     U45945      ATP1B2     ATPase, Na+/K+ transporting, beta 2 polypeptide                            1.4398346      410.9     285.38    2.5137217     486.38     193.49   0.97887236    1096.66
                     <522>ATP1B3     U51478      ATP1B3     ATPase, Na+/K+ transporting, beta 3 polypeptide                            0.8045872     3362.7    4179.41    1.1620466    1499.04      1290     0.9452279    5902.06
                     <117>ATP1B3P1   AF005898    ATP1B3P1   ATPase, Na+/K+ transporting, beta 3 pseudogene                            0.87733424    6155.07    7015.65   0.86004907    8000.28    9302.12    0.7869115    22055.9
                     <1005>ATP1B4    NM_012069   ATP1B4     ATPase, (Na+)/K+ transporting, beta 4 polypeptide                          0.8259708      262.7     318.05                                      0.81549984     283.06
                     <794>ATP2A1     U96781      ATP2A1     ATPase, Ca++ transporting, cardiac muscle, fast twitch 1                  0.85462046     157.31     184.07
                     <256>ATP2A2     M23114      ATP2A2     ATPase, Ca++ transporting, cardiac muscle, slow twitch 2                  0.59961337    2137.13    3564.18   0.71130264    3560.61    5005.76   0.72601056    2272.66
                                                            ATPase, Ca++ transporting, ubiquitous; H.sapiens mRNA for adenosine
                     <701>ATP2A3     Z69881      ATP2A3               triphosphatase, calcium.                                         1.2965399    9534.65    7353.92    1.3280392   13282.41   10001.52   1.1513306    35679.26
                     <195>ATP2B1     J04027      ATP2B1     ATPase, Ca++ transporting, plasma membrane 1                              0.65945536    8700.92    13194.1    0.5660578   13103.01   23147.83    0.9057824     16180
                     <534>ATP2B2     L00620      ATP2B2     ATPase, Ca++ transporting, plasma membrane 2                               1.1593212     313.55     270.46    0.3553459      40.68     114.48   0.69172764     187.14
                     <694>ATP2B3     U57971      ATP2B3     ATPase, Ca++ transporting, plasma membrane 3                               0.6346028    1261.07    1987.18   0.44081378     199.12     451.71
                     <450>ATP2B4     M83363      ATP2B4     ATPase, Ca++ transporting, plasma membrane 4                              0.79133314     375.63     474.68   0.42204154     542.45     1285.3    0.5446679     322.89
                     <189>ATP2C1     AF225981    ATP2C1     ATPase, Ca++-sequestering                                                  1.1234274    7358.09    6549.68    0.6523868     6969.5   10683.08   0.73329127    6127.69
                     <945>ATP4A      NM_000704   ATP4A      ATPase, H+/K+ exchanging, alpha polypeptide                                0.5989121     200.39     334.59
                     <1182>ATP4B     M75110      ATP4B      ATPase, H+/K+ exchanging, beta polypeptide                                 0.5406565     114.63     212.02     0.739633     476.05     643.63
                                                            ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9),
                     <1099>ATP5G2    D13119      ATP5G2                   isoform 2                                                    1.2918222   23598.44   18267.56    1.7493134   30311.07   17327.41   1.8507961    30401.03
                     <1178>ATP5J     M37104      ATP5J      ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6      2.4460695       433.15     177.08    2.9394343    3330.82    1133.15    1.898858     5722.74

                     <871>ATP5J2     AF047436    ATP5J2     ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2
                                                                                                                                       1.8350067    4846.73    2641.26    2.5360806   11102.53    4377.83   2.0270126    11552.37
                     <613>ATP5JD     AF087135    ATP5JD     ATP synthase, H+ transporting, mitochondrial F1F0, subunit d             1.3379493     19684.86   14712.71     2.219705     62299    28066.34   1.7212971    109947.79
                                                            ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha polypeptide,
                     <584>ATP6A1     L09235      ATP6A1                 70kD, isoform 1                                            0.16917753        301.74    1783.57   0.19973385    2223.16   11130.61   0.3693339     7437.51
                                                            ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta polypeptide,
                     <789>ATP6B1     M25809      ATP6B1                 56/58kD, isoform 1                                           0.6200286      1500.06    2419.34   0.36158153    1137.38    3145.57   0.5300785     1110.26
                                                            ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta polypeptide,
                     <647>ATP6B2     L35249      ATP6B2                 56/58kD, isoform 2                                           0.7518769     28131.58   37415.14    0.5237976   37304.53   71219.37   0.70167977   63165.48
                     <783>ATP6C      M62762      ATP6C      ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD           1.0628065     55881.26   52578.96    1.1169631    69727.4   62425.87    1.200432    76677.55
Molecular Medicine




                                                            ATPase, H+ transporting, lysosomal (vacuolar proton pump) 42kD; Vacuolar
                     <159>ATP6D      J05682      ATP6D                   proton-ATPase, subunit C; V-ATPase, subunit C               1.8891975      3462.54    1832.81   0.69796973    5239.54    7506.83   0.77523106    6077.85
                     <858>ATP6DV     X71490      ATP6DV     Vacuolar proton-ATPase, subunit D; V-ATPase, subunit D                   0.7420899     13010.84    17532.7    0.6786321   13280.28   19569.19    0.843393    32589.38
                                                            ATPase, H+ transporting, lysosomal (vacuolar proton pump) 31kD; Vacuolar
                     <635>ATP6E      X76228      ATP6E                   proton-ATPase, subunit E; V-ATPase, subunit E               1.8657131       2118.2    1135.33    1.1755426    2933.12    2495.12   1.3442384    12409.86
                     <707>ATP6F      D89052      ATP6F      ATPase, H+ transporting, lysosomal (vacuolar proton pump) 21kD           1.0134083     11950.04   11791.93    0.6301357   12293.79   19509.75   0.93723375   59865.77
                     <460>ATP6H      Y15286      ATP6H      ATPase, H+ transporting, lysosomal (vacuolar proton pump) 9kD            2.0070128     89860.61   44773.31    1.2380872   79540.43   64244.61     1.519677   97069.31
                     <154>ATP6J      AF038954    ATP6J      ATPase, H+ transporting, lysosomal (vacuolar proton pump), member J 1.7469758          16316.51    9339.86    2.4134939   48353.02   20034.45     1.118708   54660.59
                                                            ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory
                     <525>ATP6N1A    U73006      ATP6N1A                    protein 1A (110/116kD)                                  0.62170666       505.92     813.76   0.45180878     939.83    2080.15     0.57681     1330.77
                     <1016>ATP6S1    D16469      ATP6S1     ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1 0.70169425          2272.5    3238.59   0.83044505   14775.22   17791.93    1.1693561   16704.79
                     <696>ATP6S14    D49400      ATP6S14    ATPase, vacuolar, 14 kD                                                 0.94441146      8026.09    8498.51    1.6121696   25702.87   15943.03    1.3032157   38283.03
                     <99>ATP7A       L06133      ATP7A      ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome)          0.23272982      4153.15   17845.37   0.59087634    1441.88    2440.24    0.5013437    7648.49
                     <377>ATP7B      U11700      ATP7B      ATPase, Cu++ transporting, beta polypeptide (Wilson disease)            0.61168814       487.65     797.22   0.56718004     486.89     858.44   0.98316306    1283.48

                     <1671>ATP8A1    AB013452    ATP8A1     ATPase, aminophospholipid transporter (APLT), Class I, type 8A, member 1 0.770932       1770.16    2296.13   0.73161507    2102.53    2873.82   0.8305571     2085.72
                     <980>ATPASEP    AL096735    ATPASEP    ATPase type IV, phospholipid transporting (P-type)(putative)            0.99547136      3204.93    3219.51   0.91154325    2083.25    2285.41    0.974377     5545.54
                     <394>ATRX       U72938      ATRX       Alpha thalassemia/mental retardation syndrome X-linked                   0.8912864      6080.73    6822.42     0.977653    13825.9   14141.93   1.1467409    12917.83
                                                             Human vasopressin mRNA; Arginine vasopressin (neurophysin II, antidiuretic
                     <1415>AVP        M25647      AVP                     hormone, diabetes insipidus, neurohypophyseal)




                                                                                                                                                                                                                                       UNCORRECTED PROOF
                     <1294>AVPR1A     L25615      AVPR1A     Human arginine vasopressin receptor 1 (AVPR1) mRNA, complete cds         0.8624243        302.09     350.28    1.8808283     422.34     224.55   0.7887703       877.72
                                                             H.sapiens mRNA for antidiuretic hormone receptor; Arginine vasopressin receptor
                     <1413>AVPR2      Z11687      AVPR2                    2 (nephrogenic diabetes insipidus)                         0.8930747        929.78     1041.1    1.8140478    4267.91     2352.7   0.9622598      5410.46
                     <76>AXIN1        AF009674    AXIN1      Homo sapiens axin (AXIN1) ,partial cds                                   1.2184222       1594.61    1308.75    1.1854526    1440.55    1215.19     1.929105     2378.76
                     <641>AXIN2       NM_004655   AXIN2      Homo sapiens axin 2 (conductin, axil) (AXIN2), mRNA                      0.9495185       1098.46    1156.86    0.9957753    1329.36      1335    0.78200585     1103.16
                     <1634>B2M        AY007153    B2M        beta-2-microglobulin                                                      3.422228      64923.16   18971.02    1.4229157   91106.55   64028.07    1.8225079   116412.62
www.molmed.org



                     <33>BAD          U66879      BAD        Human Bcl-2 binding component 6 (bbc6) mRNA; BAD protein                 1.3958164      20492.61   14681.45    1.1046621   23286.01   21079.76    1.1448538    58537.28
                     <1271>BAG1       AF022224    BAG1       Homo sapiens Bcl-2-binding protein (BAG-1) mRNA                          1.6506195      41516.15   25151.86    4.0273433   90016.52   22351.34    1.6237065    76215.84
                     <1615>BAG3       BC006418    BAG3       Homo sapiens BCL2-associated athanogene 3 (BAG3), mRNA                  0.83804226       5951.91    7102.16    1.1449153    6190.34    5406.81    0.6751373    10332.22
                                                             Homo sapiens silencer of death domains (SODD) mRNA; BCL2-associated
                     <627>BAG4        AF111116    BAG4                   athanogene 4                                                 1.5087559       1319.92     874.84    0.5811182     615.84    1059.75   0.60123676     4539.74
                     <1602>BAG5       NM_004873   BAG5       Homo sapiens BCL2-associated athanogene 5 (BAG5), mRNA                  0.86537707      19434.56   22457.91     1.055046   28610.64   27117.91   1.1021708     23493.96

                     <1387>BAIAP2     NM_017450   BAIAP2     Homo sapiens BAI1-associated protein 2 (BAIAP2), transcript variant 1, mRNA
                                                                                                                                      1.3386453        383.04     286.14    1.0580702      166.9     157.74   1.0554763      1213.84
                     <1017>BAK1       U23765      BAK1       Human bcl2 homologous antagonist/killer (BAK)                              0.730532      7780.45   10650.39   0.84784347   18757.46   22123.73     0.905562    37711.58
                     <94>BAX          L22474      BAX        Human Bax beta mRNA, apoptosis regulator bax                             0.45164296       353.65     783.03    1.3640128    2502.65    1834.77    2.2974496      4998.4
                     <232>BCL2        M14745      BCL2       Human bcl-2 mRNA; apoptosis regulator bcl2                                1.1404643      7524.35    6597.62    1.7455858    6748.33    3865.94    0.9952572     7371.85
                     <688>BCL2A1      U29680      BCL2A1     Human A1 protein; BCL-2-related protein A1 (BCL2A1); BFL1 protein         5.0482373      3673.35     727.65     0.868769    2520.49    2901.22    1.3216834     5256.85
                     <974>BCL2L1      Z23115      BCL2L1     H.sapiens bcl-xL mRNA; BCL2-like 1                                        1.3161879     27763.56   21093.92     2.321396   19777.18    8519.52    0.6378678    47051.72
                     <1051>BCL2L2     U59747      BCL2L2     Human apoptosis regulator bclw; KIAA0271; BCL2L2                          1.1580428       160.47     138.57    1.8200867      251.9      138.4   0.87140954      456.88

                     <719>BCL3        M31732      BCL3       Human B-cell lymphoma 3-encoded protein (bcl-3) mRNA, complete cds 0.85677314             8699.7   10154.03   0.54093856   12504.07   23115.51   0.7231749     13771.71
                     <1381>BDKRB1     NM_000710   BDKRB1     Homo sapiens bradykinin receptor B1                                       0.5264996         60.3     114.53
                     <1291>BDKRB2     NM_000623   BDKRB2     Homo sapiens bradykinin receptor B2                                       2.2219548      2040.31     918.25    2.0110257    1599.59     795.41   1.6416605      1550.22
                     <1559>BDNF       X60201      BDNF       Human mRNA for brain-derived neurotrophic facor                           1.2020899       511.91     425.85    0.6347455     602.64     949.42   0.7765072       858.32

                     <684>BIK         U34584      BIK        Human Bcl-2 interacting killer (BIK) ; NBK apoptotic inducer protein; BP4; BIP1.32926
                                                                                                                                           1          5152.77    3876.42    0.8626167    4126.62    4783.84   1.2172862       6927.6
                     <138>BMI1        L13689      BMI1       Human prot-oncogene (BMI-1) mRNA, complete cds                            1.1459665      2428.67    2119.32   0.74068254    5274.26    7120.81    0.7818337     6553.69
                     <1232>BRAF       M95712      BRAF       Human B-raf mRNA, complete cds                                            1.3254552      2449.68    1848.18   0.99490947    1573.31    1581.36    1.0995184     1433.75
                     <652>BRCA1       U14680      BRCA1      Human breast and ovarian cancer susceptibility (BRCA1)                   0.84514594       836.61      989.9    0.8923796     509.87     571.36    1.3131061      618.88
                     <204>BRCA2       U43746      BRCA2      Human breast cancer susceptibility (BRCA2) mRNA                           1.1557503      1023.44     885.52    0.8561491     594.45     694.33    1.6584641     2067.01
                     <467>BTK         X58957      BTK        H.sapiens atk mRNA for agammaglobulinaemia tyrosine kinase                1.0492787       35136    33485.86    0.5693738   37763.73   66325.02   0.83133495    53101.49

                     <588>BTRC        Y14153      BTRC       Homo sapiens mRNA for beta-transducin repeat containing protein (beta-TrCP)
                                                                                                                                     1.8992786         200.07     105.34    0.1746229      59.04      338.1   0.78697896      584.08
                                                             Human DNA-binding protein (HRC1) mRNA; Chromosome 11 open reading
                     <1073>C11ORF13   M91083      C11ORF13             frame 13                                                        1.6311641      1853.72    1136.44    2.1423423     8353.7    3899.33    1.657949      8455.44
                     <1446>CALCYON    NM_015722   CALCYON    calcyon; D1 dopamine receptor-interacting protein                          0.527201       173.66      329.4    1.6702302     407.77     244.14     0.911379       463.5
Molecular Medicine




                     <1485>CAPN1      BC008751    CAPN1      calpain 1, (mu/I) large subunit                                            0.678766      1760.95    2594.34    1.0615642    2439.57    2298.09   0.91048187     2402.27
                     <1499>CAPN10     NM_023088   CAPN10     calpain 10                                                                0.7339992     11935.59   16261.04    1.9577905   66267.14   33847.92    2.4317653   155328.92
                     <1637>CAPN2      NM_001748   CAPN2      calpain 2, (m/II) large subunit                                           1.0939885     55102.69   50368.62   0.82180846   48526.16   59048.02   0.99490994    58837.81
                     <1558>CAPN3      BC004883    CAPN3      calpain 3, (p94)                                                         0.97909945      2178.32    2224.82    0.8942832      1355     1515.18    1.2887285      701.21
                     <1487>CAPN5      U94346      CAPN5      calpain 5                                                                 1.7546467      2711.21    1545.16    2.0029495    2138.97    1067.91      1.32876     2313.73
                     <1678>CAPN6      AJ000388    CAPN6      calpain 6                                                                 1.1042975      1067.16     966.37    0.8985275     600.45     668.26    0.9254386       80.18
                     <1606>CAPN7      NM_014296   CAPN7      calpain 7                                                                 1.2613584       1146.6     909.02    0.5030513     941.39    1871.36   0.67632484     1552.95
                     <1663>CAPN9      AB038463    CAPN9      calpain 9 (nCL-4)                                                         1.3349221       893.53     669.35    2.2873328      234.2     102.39    1.4384375     1135.56
                     <1525>CAPNS1     BC000592    CAPNS1     calpain, small subunit 1                                                  1.1943763     10260.78    8590.91   0.98860896   12147.73    12287.7    1.1164974    71316.23
                                                             H.sapiens mRNA for cytokine inducible nuclear protein; Cardiac ankyrin repeat
                     <401>CARP        X83703      CARP                     protein                                                      2.238035        1733      774.34                                      2.3992703       203.89
                                                             Human interleukin 1-beta converting enzyme isoform delta (IL1BCE) mRNA,
                     <1011>CASP1      U13699      CASP1                    complete cds                                                1.3774186      9753.46    7080.97   0.90601176   13761.53   15189.13   1.2325517     78729.19
                     <521>CASP10      U60519      CASP10     Human apoptotic cysteine protease Mch4 (Mch4) mRNA, complete cds 0.73688585              6120.81    8306.32    0.9570688    7862.99     8215.7   1.1472384      8484.94
                                                             Human positive regulator of programmed cell death ICH-1L (Ich-1) mRNA,
                     <979>CASP2       U13021      CASP2                   complete cds                                                 0.6459022       152.42     235.98   0.75561106     123.89     163.96   0.5633274      2951.83
                     <382>CASP3       U13737      CASP3      Human cysteine protease CPP32 isoform alpha mRNA, complete cds            1.2273748      1293.69    1054.03   0.20249376     242.79      1199    0.5369254      1439.18
                     <1030>CASP4      U28014      CASP4      Human cysteine protease (ICErel-II) mRNA, complete cds                    1.3308187     13304.74    9997.41    1.2137057   35477.15   29230.44   1.3837607     41462.08
                     <410>CASP5     U28015      CASP5    Human cysteine protease (ICErel-III) mRNA, complete cds                1.2012609      3309.63    2755.13    1.0550029     5189.38    4918.83   0.9009905     2401.41




                                                                                                                                                                                                                                 UNCORRECTED PROOF
                     <1249>CASP6    U20536      CASP6    Human cysteine protease Mch2 isoform alpha (Mch2) mRNA, complete cds1.0929793        20750.42   18985.19    1.1603488    30954.45   26676.85   1.3059946     24479.2
                     <202>CASP7     U37448      CASP7    Human Mch3 isoform alpha (Mch3) mRNA, complete cds                   0.8315343        1723.33    2072.47    0.6324382      619.84     980.08   0.7234415     2538.52
                                                         Human apoptotic cysteine protease Mch5 isoform alpha (Mch5) mRNA, complete
                     <421>CASP8     U60520      CASP8                cds                                                        1.21438         386.44     318.22    0.9758947      277.32     284.17   0.7275834      263.96
                     <702>CASP9     U60521      CASP9    Human protease proMch6 (Mch6) mRNA, complete cds                     0.7914013         659.91     833.85   0.30805752      277.07     899.41    0.6581071     1003.87
                     <1530>CCK      BC008283    CCK      Homo sapiens cholecystokinin (CCK), mRNA                             1.1776077        1509.01    1281.42    2.2213893     3327.33    1497.86    1.6335601     7791.51
www.molmed.org



                     <1175>CCNA1    U66838      CCNA1    Human cyclin A1 mRNA, complete cds                                  0.32818627          54.41     165.79    1.1148955      155.16     139.17   0.12212132       28.37
                     <52>CCNA2      X51688      CCNA2    Human mRNA for cyclin A; Cyclin A2                                    2.440213       35001.88   14343.78    2.7762358    95045.46   34235.37     2.148663   129414.35
                     <430>CCNB1     M25753      CCNB1    Human cyclin B mRNA, 3' end.; Cyclin B1                             0.61403006         386.36     629.22
                     <625>CCNB2     AF002822    CCNB2    Human cyclin B2 mRNA, complete cds                                   1.2980498         3839.8    2958.13    1.6417049     7458.38    4543.07   1.1891466     9343.09
                     <239>CCNC      M74091      CCNC     Human cyclin mRNA                                                    1.0753772         1951.1    1814.34   0.93545765     3031.65    3240.82   0.6942223     6743.89

                     <1179>CCND1    M64349      CCND1    Human G1/S-specific cyclin D1 (CCND1); cyclin PRAD1; bcl-1 oncogene 0.8976239         1155.61    1287.41    1.2284662     4585.52    3732.72   0.98398554    3525.64
                     <235>CCND2     M90813      CCND2    Human D-type cyclin (CCND2) mRNA, complete cds; cyclin D2              0.8454795      1061.77    1255.82    0.9130611     1672.81    1832.09   0.81837827     4064.5
                     <729>CCND3     M92287      CCND3    Homo sapiens cyclin D3 (CCND3) mRNA, complete cds                      1.1551044     43145.66   37352.17   0.96897155    57479.44   59320.05   0.92777276   59261.45
                     <544>CCNE1     M73812      CCNE1    Human cyclin E mRNA sequence                                          0.42809784        37.45      87.48                                        1.1089548      405.7
                     <208>CCNG1     U47413      CCNG1    Human cyclin G1 mRNA, complete cds                                      1.081423       4881.1    4513.59     0.6076624    1719.49    2829.68   0.73945147    7111.66
                     <210>CCNG2     U47414      CCNG2    Human cyclin G2 mRNA, complete cds                                     0.4988395      2727.36    5467.41   0.122169316      325.2    2661.88   0.36086702    2513.06
                     <375>CCNH      U11791      CCNH     Human cyclin H mRNA, complete cds                                      1.6482922      4792.64    2907.64     1.2477661   17673.97   14164.49    1.2733108   20531.54
                     <679>CCNI      D50310      CCNI     Human mRNA for cyclin I, complete cds                                  1.2725435     74315.54   58399.21     1.5321631   72638.95   47409.41   0.88283527   32648.59
                     <215>CCR5      U54994      CCR5     Human CC chemokine receptor 5 (CCR5) mRNA, complete cds                0.9342662      1940.91    2077.47     1.0747597    3314.86    3084.28    2.0781236    5546.47
                     <1369>CD163    NM_004244   CD163    Homo sapiens CD163 antigen (CD163)                                     0.6350997      3290.28    5180.73     0.8998616    7417.19    8242.59    1.0497757    7430.05
                     <231>CD2       M14362      CD2      Human T-cell surface antigen CD2 (T11) mRNA, complete cds              1.3139639      2649.49    2016.41     1.1285349      5237     4640.53    1.0709155   10559.88

                     <157>CD28      J02988      CD28     Human T-cell-specific homodimer surface protein CD28 mRNA, complete cds
                                                                                                                              1.0883857         909.27     835.43    1.0180136      813.23     798.84   0.5582922      639.44

                     <946>CD3D      NM_000732   CD3D     Homo sapiens CD3D antigen, delta polypeptide (TiT3 complex) (CD3D), mRNA
                                                                                                                              0.89486164       5540.33    6191.27     0.759572     3978.76    5238.16   1.0101535     12477.7
                                                         Human mRNA for T3 epsilon chain (20K) of T-cell receptor (from peripheral blood
                     <916>CD3E      X03884      CD3E                  lymphocytes).                                               0.7931074    7508.34    9466.99    0.7203655    20593.55   28587.64   1.1038653    26744.25
                     <479>CD3G      X04145      CD3G     Human mRNA for T-cell receptor T3 gamma polypeptide, RON alpha           2.8174782    9813.36    3483.03    1.0261513     5422.85    5284.65   1.4906912      9898.1
                     <997>CD3Z      J04132      CD3Z     Human T cell receptor zeta-chain mRNA, complete cds                      0.8621569    3351.48    3887.32    0.7237932     4819.08    6658.09   1.2197428     16622.8
                     <536>CD44      M59040      CD44     CD44 antigen (homing function and Indian blood group system)             0.9618019    5367.97    5581.16    1.3168951    21128.66    16044.3    1.016572    30551.89
                     <1266>CD5L     U82812      CD5L     Human scavenger receptor cysteine rich Sp alpha mRNA                     0.6988231      36.22      51.83                                       0.7608839      322.98
                                                         Human immunoglobulin superfamily member B cell receptor complex cell surface
                     <718>CD79B     M89957      CD79B                 glycoprotein (IGB) mRNA, CD79B                              1.4334407    4720.65    3293.23    2.4006631    16530.75    6885.91   1.7487589    14046.73
                     <549>CD80      M27533      CD80     CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)                       3.9635816     989.31      249.6    2.1396494      1119.7     523.31   1.3093487     1302.54
                     <1517>CD81P3   BC004108    CD81P3   CD81 partner 3                                                           0.8796592    3813.12    4334.77    1.3683076     1396.18    1020.37   1.0402579      938.76
Molecular Medicine




                     <348>CD86      U04343      CD86     Human CD86 antigen mRNA, complete cds                                    1.4226874    4410.26    3099.95    1.4287149     6625.78    4637.58   1.4881122    12298.43
                     <717>CD8A      M12828      CD8A     Homo sapiens T-cell surface protein T8 mRNA                              1.2902774    1536.23    1190.62   0.53903574     6581.47   12209.71   1.3801458     6698.51

                     <722>CD8B1     M36712      CD8B1    Human T lymphocyte surface glycoprotein (CD8-beta) mRNA, complete cds
                                                                                                                             2.1022604         2622.78     1247.6    1.5065118      9067.8    6019.07   1.7425752    12962.11
                     <1362>CD9      NM_001769   CD9      Homo sapiens CD9 antigen (p24)                                          0.7591099      877.03    1155.34    0.6239208     2797.43    4483.63    0.7442131    3779.97
                     <381>CDC10     S72008      CDC10    hCDC10=CDC10 homolog [human, fetal lung, mRNA, 2314 nt].                1.7764087    28707.28   16160.29   0.81358075    21151.13   25997.58    0.9074915   53967.66
                     <385>CDC16     U18291      CDC16    Human CDC16Hs mRNA, complete cds                                        1.1405232      5390.5    4726.34    0.7953757     5719.03    7190.35   0.91741073   17405.54
                     <299>CDC2      X05360      CDC2     Human CDC2 gene involved in Cell Cycle control; CDK1                    1.0059868      514.18     511.12    0.6280357      325.58     518.41    0.6148666     256.59
                     <427>CDC25A    M81933      CDC25A   Human cdc25A mRNA, complete cds                                         0.8388764      967.04    1152.78    1.3965216      893.69     639.94    1.0016866     516.69
                     <723>CDC25B    M81934      CDC25B   Human cdc25B mRNA, complete cds.                                          1.122159    6912.23    6159.76    1.3150303    17558.39   13352.08    1.1051317   17666.25
                     <537>CDC25C    M34065      CDC25C   Human cdc25Hs mRNA, complete cds                                          1.657388    3020.49    1822.44    1.3284131     3242.63    2440.98     1.120279    5693.65
                                                         Human homologue of S. pombe nuc2+ and A. nidulans bimA; Cell division cycle
                     <340>CDC27     U00001      CDC27              27                                                           0.85105246     3256.05    3825.91   0.70817316     3807.16    5376.03   0.6727787     2823.76
                                                         Homo sapiens PITSLRE protein kinase beta SV12 isoform (CDC2L2) mRNA,
                     <922>CDC2L1    AF067524    CDC2L1             complete cds                                                  1.0668526      386.51     362.29    1.0739242       496.4     462.23   0.40029082     134.89
                                                         Human cdc2-related protein kinase (CHED) mRNA; Cell division cycle 2-like 5
                     <237>CDC2L5    M80629      CDC2L5              (cholinesterase-related cell division controller)           0.87942344     2412.32    2743.07   0.60354835     3326.33    5511.29   0.5770534     7550.79
                     <1122>CDC34     L22005      CDC34                                                                               34
                                                           Human ubiquitin conjugating enzyme mRNA, partial cds; Cell division cycle 1.1792339        2704.42    2293.37   4.3249574    13643.77    3154.66   0.6666261     9357.61




                                                                                                                                                                                                                                       UNCORRECTED PROOF
                     <697>CDC37      U63131      CDC37     Human CDC37 homolog mRNA, complete cds                               1.0992374             4096.77    3726.92   1.0340943    10253.76    9915.69    1.2013243   20113.33
                     <251>CDC42      M35543      CDC42     Human GTP-binding protein (G25K) mRNA, complete cds                  0.9648337              426.36      441.9   0.6474456      355.48     549.05    0.7197222     352.34
                     <575>CDC6       AF022109    CDC6      Homo sapiens HsCdc18p (HsCdc18) mRNA, complete cds                   1.0742829               301.1     280.28   0.9934653      492.58     495.82   0.84058475    1294.82
                                                           Homo sapiens CDC2-related protein kinase (PISSLRE) mRNA; Cyclin-
                     <65>CDK10       L33264      CDK10                dependent kinase (CDC2-like) 10                            0.836025              678.15     811.16   1.0287062      776.56     754.89   1.8729364     1806.11
                     <538>CDK2       M68520      CDK2      Human cdc2-related protein kinase mRNA, complete cds                 1.0823456              3375.1    3118.32   1.3659371     3329.95    2437.85   1.1581712     8399.74
www.molmed.org



                     <1119>CDK3      X66357      CDK3      H.sapiens mRNA cdk3 for serine/threonine protein kinase              0.9639791              924.08     958.61   0.8125658     1375.04    1692.22     1.55012      1117.9
                                                           Human (clone PSK-J3) cyclin-dependent protein kinase mRNA; cyclin-dependent
                     <954>CDK4       M14505      CDK4                   kinase 4 (CDK4)                                         0.9205614             4310.05    4681.98   1.6455302     9533.84    5793.78   1.3889966     6068.86
                     <914>CDK5       X66364      CDK5      H.sapiens mRNA PSSALRE for serine/threonine protein kinase.          0.9690223              656.28     677.26   1.0827066     1682.97    1554.41   0.9159966     1650.69
                     <984>CDK5R1     X80343      CDK5R1    H.sapiens p35 mRNA for regulatory subunit of cdk5 kinase            0.63357306              196.49     310.13   1.7654259      282.68     160.12

                     <1040>CDK5R2    U34051      CDK5R2    Human cyclin-dependent kinase 5 activator isoform p39i mRNA, complete cds.
                                                                                                                                  0.9508649            413.36     434.72   1.1063286     1641.67    1483.89   1.1742935     1220.96
                     <915>CDK6       X66365      CDK6      H.sapiens mRNA PLSTIRE for serine/threonine protein kinase                1.8525447          237.7     128.31   0.7265567      750.94    1033.56   0.91519326    1088.54
                     <363>CDK7       X77743      CDK7      H.sapiens CDK activating kinase mRNA                                        1.164788        3481.4    2988.87   0.7840661     3295.72    4203.37    1.1725584    4558.45
                     <336>CDK8       X85753      CDK8      Homo sapiens mRNA for CDK8 protein kinase.                                1.0012814       16785.32   16763.84   1.3282962    18526.21   13947.35    0.9777855   12899.23
                     <968>CDK9       L25676      CDK9      Homo sapiens CDC2-related kinase (PITALRE) mRNA, complete cds             1.0488348        2452.48    2338.29   0.7197773     2024.64    2812.87    1.0998918    6693.49
                                                           Homo sapiens cyclin-dependent kinase inhibitor mRNA; melanoma
                     <937>CDKN1A     L25610      CDKN1A             differentiation-associated protein 6 (MDA6); CDK-interacting protein 1 (CIP1);
                                                                                                                                     1.4648796        3673.42    2507.66   1.2853224     1733.18    1348.44   0.6450665     1980.58
                                                                                    WAF1; p21
                                                           Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B)
                     <1135>CDKN1B    NM_004064   CDKN1B                mRNA                                                         0.22934839         230.08    1003.19   0.25928977     305.28    1177.37   3.0047266     3489.96
                     <1019>CDKN1C    U22398      CDKN1C    Human Cdk-inhibitor p57KIP2 (KIP2) mRNA, complete cds                    0.77093714        1480.13    1919.91   1.4476027     4397.05    3037.47   0.6664933     7599.21
                                                           Human CDK4-inhibitor (p16-INK4) mRNA; cyclin-dependent kinase 4 inhibitor
                     <654>CDKN2A     L27211      CDKN2A                (CDK4I; CDKN2); multiple tumor suppressor 1 (MTS1); p16 1.4930629             22495.38    15066.6   1.7810733    27463.99   15419.91   1.4098272    39994.56
                     <1153>CDKN2B    U17075      CDKN2B    Human p14-CDK inhibitor mRNA, complete cds.; p15                    0.9147947               127.87     139.78   1.2848104      245.72     191.25
                                                           Homo sapiens cyclin-dependent kinase inhibitor (CDKN2C) mRNA, complete
                     <598>CDKN2C     AF041248    CDKN2C              cds.; p18                                                 1.0881696              3251.32    2987.88   1.6877925     6557.26    3885.11   1.2088757     4749.66
                     <416>CDKN2D     U40343      CDKN2D    Human CDK inhibitor p19INK4d mRNA, complete cds; p19                1.0718298              7495.81    6993.47   1.0978539    56132.85   51129.62   0.7678231    31643.85
                                                           Homo sapiens CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) mRNA;
                     <1137>CEBPB     NM_005194   CEBPB                 NF-IL6                                                  0.9144979              1336.31    1461.25   0.80864197    2375.79      2938    0.6997495    21740.42
                     <724>CEL        M85201      CEL       Human cholesterol esterase mRNA                                     1.9082189               175.06      91.74   0.54710776     123.05     224.91
                     <726>CES1       L07765      CES1      Human carboxylesterase mRNA                                         1.6208744               266.18     164.22    2.8279564    2151.99     760.97   1.6084657     2253.75
                                                           Homo sapiens Casper mRNA; CASP8 and FADD-like apoptosis regulator; I-
                     <457>CFLAR      AF010127    CFLAR                FLICE                                                    0.7564429              3565.07    4712.94   0.38987932   12822.07   32887.28   0.6014395    43013.14
                                                           Human cystic fibrosis mRNA, encoding a presumed transmembraneconductance
                     <236>CFTR       M28668      CFTR                  regulator (CFTR).                                       1.0048407              2437.02    2425.28   1.0852541     1604.57    1478.52   1.1964281      3283.8
                     <1618>CGI-11    NM_015941   CGI-11    Vacuolar ATPase subunit H                                                 1.1004523        4665.61    4239.72   1.2554789     7176.92    5716.48   0.81216455   24016.43
Molecular Medicine




                     <1455>CGI-152   AK026044    CGI-152   CGI-152 protein                                                           1.0282644        1781.18    1732.22   1.2164463     2014.35    1655.93    1.1253995     7593.7
                     <125>CHEK1      AF016582    CHEK1     checkpoint kinase 1 (CHK1)                                               0.23356223          125.5     537.33                                       0.8261689     806.44
                     <1199>CHRAC17   AF070640    CHRAC17    histone fold protein CHRAC17; DNA polymerase epsilon p17 subunit         0.9541593         5809.8    6088.92    1.2694311   13237.78   10428.12    1.0832654    25477.7
                     <1477>CHRM1     BC007740    CHRM1     cholinergic receptor, muscarinic 1                                        1.2273517         988.73     805.58    1.0756905     283.95     263.97
                     <1691>CHRM2     NM_000739   CHRM2     cholinergic receptor, muscarinic 2                                         1.663688        7614.65    4576.97    1.3925624    9250.18    6642.56    1.3126626    19110.07
                     <1520>CHRM3     NM_000740   CHRM3     cholinergic receptor, muscarinic 3                                        0.9593231         383.24     399.49    0.8600497     256.14     297.82   0.99921423      343.36
                     <1459>CHRM4     NM_000741   CHRM4     cholinergic receptor, muscarinic 4                                        1.4714445        5339.46    3628.72    1.9610589    5799.42    2957.29    1.7273184    10076.52
                     <1593>CHRNA1    BC006314    CHRNA1    cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)             0.7532908         468.69     622.19    1.0876303     394.44     362.66   0.56508195      119.69
                     <1648>CHRNA3    BC002996    CHRNA3    cholinergic receptor, nicotinic, alpha polypeptide 3                      0.9312954        4019.62    4316.16     1.338081    4102.73    3066.13    1.3484437     5781.83
                     <1445>CHRNA4    U62433      CHRNA4    cholinergic receptor, nicotinic, alpha polypeptide 4                      0.9932743         555.29     559.05   0.35513258       69.4     195.42    1.1498728       853.7
                     <1658>CHRNA6    U62435      CHRNA6    cholinergic receptor, nicotinic, alpha polypeptide 6                      1.1129003          366.3     329.14     1.082871     238.08     219.86    1.3205818      658.31
                     <1596>CHRNA7    X70297      CHRNA7    cholinergic receptor, nicotinic, alpha polypeptide 7                      1.1376789        3039.15    2671.36    1.4122742    3168.31    2243.41    1.2686545     4673.52
                     <1698>CHRNA9    NM_017581   CHRNA9    cholinergic receptor, nicotinic, alpha polypeptide 9                      1.2228549        1748.34    1429.72    1.3633536    2372.14    1739.93    1.3863167     6931.57
                     <1497>CHRNB1    X14830      CHRNB1    cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)              1.2413801        2375.89    1913.91    1.6345092    2358.27     1442.8    1.3362132     2952.59
                     <1484>CHRNB2    U62437      CHRNB2    cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)            0.8307915       19901.02   23954.29    2.1480482   55721.87    25940.7    1.9662982   125597.22
                     <833>CHST1      AB003791    CHST1     Homo sapiens mRNA for keratan sulfate Gal-6-sulfotransferase              1.0551256        4703.37    4457.64    1.1672686    2149.35    1841.35    1.1268698     3826.32
                                                           Homo sapiens carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
                     <642>CHST2      NM_004267   CHST2                                                                           0.49220628      9499.04    19298.9    0.4937798   16781.18   33985.15   0.6484457   16009.97
                                                                      (CHST2)




                                                                                                                                                                                                                                 UNCORRECTED PROOF
                     <891>CHST3      AB012192    CHST3     Homo sapiens mRNA for chondroitin 6-sulfotransferase                  0.91821736      13342.14   14530.48   2.2865486   41805.45   18283.21 0.48051822    47187.51
                                                           Homo sapiens carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
                     <497>CHST4      NM_005769   CHST4                                                                            1.0848085      2012.45    1855.12    0.985681    1934.33    1962.43    0.9739641    2399.75
                                                                      (CHST4)
                                                           Homo sapiens carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
                     <1006>CHST5     NM_012126   CHST5                                                                           0.72738826        85.81     117.97                                      2.9235957      26.02
                                                                      (CHST5)

                     <122>CHUK       AF009225    CHUK                                                                               0.85774
                                                           Homo sapiens IkB kinase alpha subunit (IKK alpha) mRNA, complete cds; IKK1               550      641.22 0.60127145     2517.65    4187.21    0.641233      5949.7
www.molmed.org




                     <1624>CL683     AF091092    CL683     weakly similar to glutathione peroxidase 2                             1.3796237      3969.26    2877.06    1.6701363   4762.01    2851.27    1.0390033   18001.24
                     <388>CLK1       L29222      CLK1      Homo sapiens clk1 mRNA; CDC-like kinase 1                              1.5568593      6938.47    4456.71 0.51306355     2390.05    4658.39    1.4478407    8699.38
                     <998>CLK2       L29216      CLK2      Homo sapiens clk2 mRNA; CDC-like kinase 2                              0.9592373      3057.54    3187.47    0.9140786   3605.72    3944.65 0.82064307      3672.23
                     <95>CLK3        L29220      CLK3      Homo sapiens clk3 mRNA; CDC-like kinase 3                              1.2811801       699.96     546.34    1.0317677    572.92     555.28    0.7905288    2573.44
                     <1628>CLOCK     NM_004898   CLOCK     Clock (mouse) homolog                                                   1.255828       3695.5    2942.68    1.2574012    3017.7    2399.95    1.2542553     3408.1
                     <1578>COL4A6    BC005305    COL4A6    collagen, type IV, alpha 6                                            0.85529757        278.1     325.15                                      0.1054315      16.81
                     <1062>COMT      M58525      COMT      Homo sapiens catechol-O-methyltransferase (COMT) mRNA                  0.6680591       235.09      351.9    1.429432     215.93     151.06 0.53147805       289.14
                     <1230>COPS5     U65928      COPS5     Human Jun activation domain binding protein mRNA, complete cds         1.1490372      9750.96     8486.2    1.4133309   27812.12   19678.42   1.6791362   22968.23
                                                           Homo sapiens COX10 (yeast) homolog, cytochrome c oxidase assembly protein
                     <1275>COX10     NM_001303   COX10                                                                         0.9392348         2845.44    3029.53    1.2943298   5601.16    4327.46    1.0254343     3102.8
                                                                      (heme A: farnesyltransferase)
                                                           Homo sapiens COX11 (yeast) homolog, cytochrome c oxidase assembly protein
                     <1295>COX11     NM_004375   COX11                                                                         0.9878713         2362.02    2391.02    1.1930735   3598.56    3016.21    1.2823591    2022.37
                                                                      (COX11)
                                                           Homo sapiens COX15 (yeast) homolog, cytochrome c oxidase assembly protein
                     <1296>COX15     NM_004376   COX15                                                                         1.0773674         7276.26    6753.74    1.1005216   5087.26    4622.59    1.0113063   12348.19
                                                                      (COX15)

                     <1371>COX17     NM_005694   COX17                                                                         2.3929048
                                                           Homo sapiens COX17 (yeast) homolog, cytochrome c oxidase assembly protein              5301.6    2215.55    1.8561171   10275.52   5536.03    1.6723752    9078.94
                                                           Homo sapiens cytochrome c oxidase subunit IV (COX4), nuclear gene encoding
                     <1397>COX4      NM_001861   COX4                                                                            1.2643428       14587.14   11537.33   2.5215774   72295.21   28670.63   2.0622468   56275.13
                                                                      mitochondrial protein
                     <1297>COX5A     NM_004255   COX5A     Homo sapiens cytochrome c oxidase subunit Va                           0.9336665      17418.1    18655.59   1.4171292   44840.39   31641.71   1.2362617   40832.82
                                                           Homo sapiens cytochrome c oxidase subunit Vb (COX5B), nuclear gene
                     <1419>COX5B     NM_001862   COX5B                                                                            1.3878225       890.76     641.84    1.8055627   9904.18    5485.37    1.4269608   43860.81
                                                                     encoding mitochondrial protein

                     <1388>COX6A1    NM_004373   COX6A1    Homo sapiens cytochrome c oxidase subunit VIa polypeptide 1 (COX6A1) 1.4828817        1765.43    1190.54    1.6373044   10879.43   6644.72    1.3254116   13619.12
                                                           Homo sapiens cytochrome c oxidase subunit VIb (COX6B), nuclear gene
                     <1403>COX6B     NM_001863   COX6B                                                                             0.7806488      934.14    1196.62    1.7855421   10880.63   6093.74    1.4073507   14712.36
                                                                     encoding mitochondrial protein
                                                           Homo sapiens cytochrome c oxidase subunit VIc (COX6C), nuclear gene
                     <1345>COX6C     NM_004374   COX6C                                                                             3.0912037     8954.97    2896.92     2.80256    25095.16   8954.37    3.284619    66296.92
                                                                     encoding mitochondrial protein
                                                           Homo sapiens cytochrome c oxidase subunit VIIa polypeptide 1(muscle)
                     <1420>COX7A1    NM_001864   COX7A1              (COX7A1), nuclear gene encoding mitochondrial protein
Molecular Medicine




                                                           Homo sapiens cytochrome c oxidase subunit VIIa polypeptide 2 (liver) (COX7A2),
                     <1363>COX7A2    NM_001865   COX7A2                                                                            3.1509693     14562.33   4621.54    2.860766    51585.22   18031.96    2.28055    42572.62
                                                                        nuclear gene encoding mitochondrial protein
                     <1298>COX7A2L   NM_004718   COX7A2L   Homo sapiens cytochrome c oxidase subunit VIIa polypeptide 2 like      1.1574451      13367.98   11549.56   1.8294053   17523.27   9578.67    1.5377538   23427.85
                     <1364>COX7B     NM_001866   COX7B     Homo sapiens cytochrome c oxidase subunit VIIb                         1.3834605      3452.73    2495.72    2.2024493   12975.51    5891.4    2.070779    14162.41
                     <1444>COX7C     NM_001867   COX7C     Homo sapiens cytochrome c oxidase subunit VIIc                         5.5867352      44714.61   8003.71    4.702427    80220.21   17059.32   2.5392854   145937.84
                                                           Homo sapiens cytochrome c oxidase subunit VIII (COX8), nuclear gene encoding
                     <1435>COX8      NM_004074   COX8                                                                             0.9576761      3175.52    3315.86    1.6357076   1697.93    1038.04    1.4957421    3994.08
                                                                      mitochondrial protein
                     <1365>CPE       NM_001873   CPE       Homo sapiens carboxypeptidase E (CPE)                                  0.5240408       139.18     265.59 0.51853526       114.7      221.2
                                                           Homo sapiens carnitine palmitoyltransferase I, liver (CPT1A),nuclear gene
                     <1340>CPT1A     NM_001876   CPT1A                                                                               0.8952647   1798.73    2009.16    0.5805843   1717.38    2958.02    0.5808127    1116.99
                                                                      encoding mitochondrial protein
                     <1436>CPT1B     NM_004377   CPT1B     Homo sapiens carnitine palmitoyltransferase I, muscle (CPT1B)          0.8934047      2152.48     2409.3    1.6923178   15080.48   8911.14    2.4933407   21334.77
                                                           Homo sapiens carnitine palmitoyltransferase II (CPT2), nuclear gene encoding
                     <1366>CPT2      NM_000098   CPT2                                                                              0.77940434    3318.54    4257.79    1.0306981   12776.44   12395.91   1.0465051    7752.96
                                                                      mitochondrial protein
                                                           Complement component (3b/4b) receptor 1, including Knops blood group
                     <1239>CR1       Y00816      CR1                                                                               0.98116165    16988.51   17314.69   1.4783067   38637.76   26136.5    1.9688206   94714.86
                                                                    system; CD35
                     <246>CR2        M26004      CR2       Complement component (3d/Epstein Barr virus) receptor 2; CD21          1.6130065       620.33     384.58    1.8036337   3444.85    1909.95 0.95321006      1062.61
                                                          Human death domain containing protein CRADD mRNA; CASP2 and RIPK1
                     <46>CRADD      U84388      CRADD                                                                       1.02503           1813.36    1769.08    0.9890559   2482.55    2510.02    0.8773836   2653.12
                                                                  domain containing adaptor with death domain




                                                                                                                                                                                                                             UNCORRECTED PROOF
                     <1346>CREB1    NM_004379   CREB1     Homo sapiens cAMP responsive element binding protein 1 (CREB1)      0.87385714      7890.03    9028.97    0.4681462   12858.75   27467.38   0.5989141   11837.37
                     <291>CREBBP    U47741      CREBBP    Human CREB-binding protein (CBP) mRNA, complete cds                  0.5544373      6867.97    12387.28   0.6023746   15798.25   26226.62   0.5849823   13351.53
                     <1276>CRH      NM_000756   CRH       Homo sapiens corticotropin releasing hormone (CRH), mRNA.            2.2456162       197.21      87.82    1.1966503    471.54     394.05    1.0728062     305.9

                     <1267>CRHBP    X58022      CRHBP     Human mRNA for corticotropin-releasing factor binding protein (CRF-BP). 0.9674412   1071.77    1107.84 0.71743566      893.15    1244.92 0.92621994      607.73
                                                                                                                               1.6085638       312.93     194.54    3.3420992    298.65      89.36    1.3781149    955.64
www.molmed.org



                     <1418>CRHR1    L23332      CRHR1     Human corticotropin releasing factor receptor mRNA

                     <1408>CRHR2    U34587      CRHR2     Human corticotropin-releasing factor receptor 2 mRNA                 1.1152484       374.69     335.97    1.1361418   1366.54    1202.79    1.1384645    1452.1
                     <933>CRKL      X59656      CRKL      H.sapiens crk-like gene CRKL                                         0.7756219       537.25     692.67    0.8303156    1313.8    1582.29    0.5451314    3100.8
                     <695>CRYBA4    U59057      CRYBA4    Human beta-A4 crystallin (CRYBA4) mRNA                               0.8312965        265.3     319.14    1.0113797    149.31     147.63
                     <1037>CRYBB1   U35340      CRYBB1    Human beta B1-crystallin mRNA                                        1.2171271      4518.84    3712.71    1.9544632   5435.46    2781.05    1.3073468   2639.35
                                                          Human chromosome segregation gene homolog CAS mRNA, Chromosome
                     <200>CSE1L     U33286      CSE1L                                                                              1.391038   5861.25    4213.58 0.74608743     4156.52    5571.09    0.7953142   5663.83
                                                                  segregation 1 (yeast homolog)-like
                                                          Human macrophage-specific colony-stimulating factor (CSF-1) mRNA,complete
                     <541>CSF1      M37435      CSF1                                                                             1.3115258     486.34     370.82 0.85980153     2082.19    2421.71    1.091027    7274.75
                                                                     cds
                                                          Human macrophage colony stimulating factor I receptor precursor (CSF1R); fms
                     <36>CSF1R      X03663      CSF1R                                                                            0.8980216    2334.03    2599.08    0.9263106   6863.35    7409.34    0.9129376   13029.49
                                                                      proto-oncogene (c-fms)

                     <728>CSF2      M10663      CSF2      Human T-cell granulocyte-macrophage colony stimulating factor (GM-CSF) 1.0646592
                                                                                                                                 mRNA         3451.87    3242.23    0.9715868   1859.52     1913.9    1.1987358   3129.12

                     <466>CSF2RA    M73832      CSF2RA    Human GM-CSF receptor (GM-CSF receptor) mRNA, complete cds           0.9205179       4935.9    5362.09     0.37294    1413.23    3789.43    0.7907508   9448.23
                     <964>CSF2RB    M59941      CSF2RB    Human GM-CSF receptor beta chain mRNA; IL3R-beta                      0.977393      1010.38    1033.75    0.9135555   1912.83    2093.83    1.1758763   2151.83
                     <862>CSF3      X03438      CSF3      Human mRNA for granulocyte colony-stimulating factor (G-CSF).        0.7993854       476.01     595.47    1.1191609    551.03     492.36 0.33825788      156.38
                                                          Human granulocyte colony-stimulating factor receptor (G-CSFR-1) mRNA,
                     <748>CSF3R     M59818      CSF3R                                                                           0.6984633     15340.95   21963.86   0.500682    32865.63   65641.73 0.97986454    62588.81
                                                                     complete cds
                     <1416>CSH2     V00573      CSH2      Human mRNA encoding placental lactogen hormone                       1.4191551        64.16      45.21
                     <405>CSNK1A1   L37042      CSNK1A1   Homo sapiens casein kinase I alpha isoform (CSNK1A1) mRNA            1.2584913      8154.13    6479.29    0.5353059   4872.14     9101.6    0.7663025   3695.08
                     <532>CSNK2A1   M55265      CSNK2A1   Human casein kinase II alpha subunit mRNA, complete cds.             0.8403506      2713.03    3228.45 0.94784296     5733.54    6049.04    0.779327    3695.21
                     <531>CSNK2A2   M55268      CSNK2A2   Human casein kinase II alpha' subunit mRNA, complete cds             1.0047016       698.78     695.51    0.7474971   1207.29    1615.11 0.58278143     2198.84
                     <845>CSNK2B    X16312      CSNK2B    Human mRNA for phosvitin/casein kinase II beta subunit               1.1043398      5519.48    4997.99    1.4658842   19988.65   13635.9    1.1598479   31027.68
                     <1078>CST      D88667      CST       Homo sapiens mRNA for cerebroside sulfotransferase                   0.9870999       942.71     955.03    1.9651994   1072.37     545.68    0.2316008    147.18
                                                          CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase,
                     <921>CTDP1     AF081287    CTDP1                                                                           0.86126417    1447.32    1680.46    0.8078269     893.4    1105.93 0.54734254      806.98
                                                                      subunit 1
                     <241>CTGF      M92934      CTGF      Human connective tissue growth factor (CTGF)                        0.95152646       489.96     514.92    1.7193961    539.77     313.93    0.6637683   1074.09
Molecular Medicine




                     <1229>CTNNB1   X87838      CTNNB1    H.sapiens mRNA for beta-catenin                                     0.89293665      9631.17    10785.95   1.0819924   14777.3    13657.49   1.020789    22165.25
                     <330>CTNND2    U96136      CTNND2    Homo sapiens delta-catenin mRNA, complete cds, Arm                   0.8576249       312.63     364.53    0.6217387    231.15     371.78
                     <1702>CTSB     NM_001908   CTSB      cathepsin B                                                          1.1400193      37783.15   33142.55   2.3252919   34986.85   15046.22   0.9858466   62970.91
                     <1610>CTSC     X87212      CTSC      cathepsin C                                                          1.1789489      18849.8    15988.65   0.6275635   18278.34   29125.88   1.1092756   44385.56
                     <1481>CTSD     BC016320    CTSD      cathepsin D (lysosomal aspartyl protease)                           0.82957214      9346.59    11266.76   0.9952134   5709.36    5736.82    1.3910927   17049.05
                     <1582>CTSE     NM_001910   CTSE      cathepsin E                                                          0.6408608      4958.84    7737.78 0.88375366      4357.1    4930.22 0.98066175     11200.04
                     <1522>CTSF     AL137742    CTSF      cathepsin F                                                         0.89362144       983.35    1100.41    1.3329791   1366.93    1025.47    1.6876607   3267.75
                     <1468>CTSG     NM_001911   CTSG      cathepsin G                                                          0.8923393       212.93     238.62    2.5114725    139.01      55.35    2.014484    1126.58
                     <1644>CTSK     U20280      CTSK      cathepsin K (pycnodysostosis)                                        1.0232447       2359.5     2305.9    1.0191544   3947.45    3873.26    1.5068419   4590.91
                     <1566>CTSL2    AB001928    CTSL2     cathepsin L2                                                         1.1540189      1320.74    1144.47 0.98558193     1186.69    1204.05    1.127766    3876.56
                     <1681>CTSS     BC002642    CTSS      cathepsin S                                                          1.2303721      79844.11   64894.28 0.85252523    54811.86   64293.53   1.3727105   87681.83
                     <1466>CTSW     NM_001335   CTSW      cathepsin W (lymphopain)                                             1.9438791      7764.65    3994.41    0.6891751   5002.35    7258.46    1.746078    89246.1
                                                            Human (clone L5) orphan G protein-coupled receptor mRNA, complete cds;
                     <175>CXCR4      L06797      CXCR4                                                                            0.6175779     21850.69   35381.27   0.6223672   18062.39   29022.08   1.0576411    67556.79
                                                                       Chemokine (C-X-C motif), receptor 4 (fusin)




                                                                                                                                                                                                                                UNCORRECTED PROOF
                                                            Human cytochrome P450c17 (steroid 17-alpha-hydroxylase/17,20 lyase) mRNA,
                     <431>CYP17      M14564      CYP17                                                                            0.6836632      667.98     977.06    5.495529     116.78      21.25    1.1263059      411.8
                                                                        complete cds.
                                                            Homo sapiens cytochrome P450, subfamily I (aromatic compound-inducible),
                     <1212>CYP1A2    NM_000761   CYP1A2                                                                         0.83408797      4559.05    5465.91    0.9789945   7565.64    7727.97    1.5141997    9436.28
                                                                        polypeptide 2 (CYP1A2) mRNA

                     <370>CYP1B1     U03688      CYP1B1     Human dioxin-inducible cytochrome P450 (CYP1B1) mRNA, complete cds 1.7305555        12384.08   7156.13    0.7052861   26468.66   37528.97   1.1090219    24549.33

                     <782>CYP21A2    M17252      CYP21A2    Human cytochrome P450c21 mRNA, 3' end                                0.6219796      6311.83    10147.97   0.5205675   2611.51    5016.66    0.5993874    5047.01
www.molmed.org



                                                            Homo sapiens cytochrome P450, subfamily XXVIA, polypeptide 1 (CYP26A1)
                     <1213>CYP26A1   NM_000783   CYP26A1                                                                        24.601067          92.5       3.76                                       1.275361     515.08
                                                                       mRNA, and translated products
                     <730>CYP27A1    M62401      CYP27A1    Human sterol 27-hydroxylase (CYP27) mRNA, complete cds.              0.6079588       1868.3    3073.07 0.43593618     3458.26    7932.95    1.8107944    24344.7
                                                            Homo sapiens cytochrome P450, subfamily XXVIIB (25 hydroxyvitamin D-1-alpha-
                     <491>CYP27B1    NM_000785   CYP27B1                                                                         2.3685849       190.15      80.28    0.9176172    332.26     362.09 0.70690584       327.46
                                                                         hydroxylase), polypeptide 1 (CYP27B1) mRNA.

                     <1176>CYP2A13   U22028      CYP2A13    Human cytochrome P450 (CYP2A13) gene, complete cds.; gene only       0.19793886       34.38     173.69    1.8077143    284.95     157.63
                     <1063>CYP2A6    M33318      CYP2A6     Human cytochrome P450IIA3 (CYP2A3) mRNA, complete cds                0.91945964     1565.38     1702.5    2.3747845   8054.58    3391.71     2.145527    11221.6
                     <1036>CYP2A7    U22029      CYP2A7     Human cytochrome P450 (CYP2A7) mRNA, complete cds                    0.6960686       752.13    1080.54    0.7254246   1088.71    1500.79    0.7816452    1453.18
                     <896>CYP2B6     X13494      CYP2B6     Human mRNA for cytochrome P-450IIB6                                  1.3066456       174.79     133.77                                      0.78750956    196.46
                     <731>CYP2C18    M61856      CYP2C18    Human cytochrome P4502C18 (CYP2C18) mRNA, clone 29c                  1.0015129        86.06      85.93                                       0.691331     404.56
                     <733>CYP2C19    M61854      CYP2C19    Human cytochrome P4502C19 (CYP2C19) mRNA, clone 11a                  0.84825236     1310.27    1544.67    1.133643    4478.82    3950.82 0.98189425      27123.69
                                                            Homo sapiens cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase),
                     <1214>CYP2C8    NM_000770   CYP2C8                polypeptide 8 (CYP2C8) mRNA
                     <732>CYP2C9     M61857      CYP2C9     Human cytochrome P4502C9 (CYP2C9) mRNA, clone 65                                                                                            15.499999      92.69
                     <1065>CYP2D6    M20403      CYP2D6     Human cytochrome P450 db1 mRNA (CYP2D6), complete cds                1.3097209       579.08     442.14    1.2837892    359.14     279.75    1.3554606     797.16
                     <90>CYP2E       J02625      CYP2E      Human cytochrome P-450j mRNA, complete cds                           1.1020048       917.97       833     1.6760192    805.83      480.8
                     <734>CYP2F1     J02906      CYP2F1     Human cytochrome P450IIF1 protein (CYP2F) mRNA, complete cds         0.7896382      2381.92    3016.47 0.48820412     1449.19    2968.41    0.8387326    3650.29

                     <514>CYP2J2     U37143      CYP2J2     Human cytochrome P450 monooxygenase CYP2J2 mRNA, complete cds 0.8305978              430.64     518.47                                      0.8380176     317.55

                     <190>CYP39A1    AF237982    CYP39A1                                                                       1.2259979
                                                            Homo sapiens oxysterol 7alpha-hydroxylase (CYP39A1) mRNA, complete cds.              225.13     183.63    0.5919513    310.07     523.81 0.41783047       169.94

                     <570>CYP3A3     D00003      CYP3A3     Homo sapiens mRNA for cytochrome P-450, complete cds                 0.65888244      270.01      409.8                                       1.546351     387.33
                     <1225>CYP3A4    AF182273    CYP3A4     Homo sapiens cytochrome P450-3A4 (CYP3A4) mRNA, complete cds           7.270357      181.25      24.93    13.089254     79.19       6.05    3.8433514      379.8
                     <631>CYP3A5P1   L26985      CYP3A5P1   Human cytochrome P450 pseudogene mRNA                                1.0604795      9002.92    8489.48 0.82875013      8236.5    9938.46    0.9431163    9996.73

                     <351>CYP3A7     NM_000765   CYP3A7                                                                            0.785928
                                                            Homo sapiens cytochrome P450, subfamily IIIA, polypeptide 7 (CYP3A7) mRNA            423.01     538.23 0.43494081      132.67     305.03    1.0224824     876.84
Molecular Medicine




                     <432>CYP4A11    L04751      CYP4A11    Human cytochrome p-450 4A (CYP4A) mRNA, complete cds                 0.8225009       4007.2    4871.97    0.5735103   1171.67    2042.98    1.0882517    3091.07
                     <540>CYP4B1     J02871      CYP4B1     Human lung cytochrome P450 (IV subfamily) BI protein, complete cds   0.77043563     1179.56    1531.03    0.5649531    580.93    1028.28    0.8066522     954.81
                     <669>CYP4F2     U02388      CYP4F2     Human cytochrome P450 4F2 (CYP4F2) mRNA, complete cds                0.9285546       907.17     976.97 0.45449018      919.42    2022.97    0.5816356    1346.12
                                                            Homo sapiens cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene B4
                     <352>CYP4F3     NM_000896   CYP4F3                                                                            0.92880064    2709.2    2916.88    0.4281992    782.29    1826.93    0.7703938     2629.2
                                                                       omega hydroxylase) (CYP4F3) mRNA

                     <993>CYP4F8     NM_007253   CYP4F8                                                                          0.94631076
                                                            Homo sapiens cytochrome P450, subfamily IVF, polypeptide 8 (CYP4F8), mRNA            220.85     233.38    0.5748832    580.77    1010.24 0.79365057       863.96
                                                            Human lanosterol 14-demethylase cytochrome P450 (CYP51) mRNA, complete
                     <1173>CYP51     U23942      CYP51                                                                       0.71116626          669.94     942.03    1.4078677   4760.62    3381.44    1.4601319    3295.43
                                                                       cds
                     <243>CYP7A1     M93133      CYP7A1     Human cholesterol 7-alpha hydroxylase (CYP7) mRNA, complete cds      1.3157667      1759.43    1337.19    1.9722251   1348.43     683.71     0.958085    3468.67

                     <615>CYP8B1     AF090318    CYP8B1                                                                        0.95020366
                                                            Homo sapiens sterol 12-alpha hydroxylase CYP8B1 (Cyp8b1) mRNA,partial cds           6511.66    6852.91    0.9276997   8652.71    9327.06    0.9381091     9726.7
                                                            Human ionizing radiation resistance conferring protein mRNA; Death associated
                     <508>DAP3       U18321      DAP3                                                                               1.8623658   19283.55   10354.33   1.248678    28018.1    22438.21   1.4030513    69669.79
                                                                        protein 3
                     <284>DAPK1      X76104      DAPK1      H.sapiens DAP-kinase mRNA                                            0.78082514     2383.57    3052.63 0.36156484     2160.69    5975.94 0.43630105      2496.58
                     <1673>DATF1     AB002331    DATF1      death associated transcription factor 1                              1.1211877      5897.66    5260.19    1.0881389   3194.21    2935.48    1.2482126    5448.86
                     <809>DAXX            AF015956    DAXX        Homo sapiens Fas-binding protein Daxx mRNA, complete cds                1.0431696      4963.13    4757.74    1.2113585    11446.15   9449.02    1.0984024   27529.72




                                                                                                                                                                                                                                          UNCORRECTED PROOF
                     <1422>DBH            NM_000787   DBH         Dopamine beta-hydroxylase (dopamine beta-monooxygenase)                                                                                         6.8186064     219.15
                                                                  diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding
                     <1529>DBI            BC006466    DBI                                                                                 5.3939247      10447.87   1936.97    3.0195549    20053.41   6641.18    2.7244134   168648.33
                                                                              protein)

                     <492>DCC             X76132      DCC                                                                                 0.594964
                                                                  Human tumor suppressor protein DCC precursor; colorectal cancer suppressor             4205.92     7069.2    0.5572495    1875.49    3365.62    0.6880587    3431.17

                     <1261>DDC            M76180      DDC         Dopa decarboxylase (aromatic L-amino acid decarboxylase)                1.0074495       120.36     119.47    1.3388968      218.2     162.97
                                                                                                                                          2.0317295       488.57     240.47    1.1026419     825.57     748.72    2.2810662     848.99
www.molmed.org



                     <1401>DDIT3          NM_004083   DDIT3       Homo sapiens DNA-damage-inducible transcript 3; GADD153
                                                                  Human mRNA for KIAA0115 gene; Dolichyl-diphosphooligosaccharide-protein
                     <958>DDOST           D29643      DDOST                                                                           0.8839326          15535.39   17575.31   1.3132111    36163.38   27538.13   1.4098663   36373.72
                                                                          glycosyltransferase
                     <796>DFFA            U91985      DFFA        Human DNA fragmentation factor-45 mRNA, DFF                             0.90344036     1620.23     1793.4 0.91156626      2834.57    3109.56    1.118499     2059.66
                     <1507>DHCR7          BC000054    DHCR7       7-dehydrocholesterol reductase                                          1.2741808       541.96     425.34    1.0814308     805.72     745.05    1.0433668    1574.91
                     <737>DIA1            M16462      DIA1        Human NADH-cytochrome b5 reductase mRNA, 3' end                          2.015708       170.67      84.67    0.8504673     244.79     287.83    1.2417291     417.37
                     <109>DIA4            J03934      DIA4        Human, NAD(P)H:menadione oxidoreductase mRNA                             0.907016       354.87     391.25    1.8758273      9538     5084.69    1.7950151   11020.37
                     <1351>DKFZP434A014   AF241254    DKFZP434A   Homo sapiens angiotensin converting enzyme-like protein mRNA             0.689414       158.71     230.21                                       1.1387708     238.47
                                                                  Human neuroendocrine-dlg (NE-dlg) mRNA; synapse-associated protein 102
                     <1171>DLG3           U49089      DLG3                                                                             0.3989743            52.9     132.59                                       1.216756      674.46
                                                                            (SAP102); human homolog of Drosophila discs large (DLG)

                     <812>DMBT1           AJ000342    DMBT1       Homo sapiens mRNA for DMBT1 6 kb transcript variant 1 (DMBT1/6kb.1). 2.1106224         2889.02     1368.8    1.4257073    1714.57    1202.61    1.5143003    1155.29

                     <720>DOK1            U70987      DOK1        Docking protein 1, 62kD (downstream of tyrosine kinase 1)               0.6668754      6836.02    10250.82    1.149481    11362.46   9884.86    1.1659281    12700.7
                     <380>DPYD            U09178      DPYD        Human dihydropyrimidine dehydrogenase mRNA                              1.9124032      75316.14   39382.98   0.9452318    40907.07   43277.29   1.2970471   78607.42
                     <1494>DRD2           S69899      DRD2        dopamine receptor D2                                                    1.2584705      12878.57   10233.51    1.572283    11657.44   7414.34    1.6522986   10418.52
                     <1574>DRIP78         AF351784    DRIP78      dopamine receptor interacting protein                                   0.8231939       695.64     845.05    0.6756371    1150.86    1703.37    0.7867882    6929.96
                                                                  Human heparin-binding EGF-like growth factor mRNA (HBEGF); diphtheria toxin
                     <255>DTR             M60278      DTR                                                                                  1.0460378      356.27     340.59 0.63106406       364.49     577.58    1.0507731     342.51
                                                                              receptor (DTR)
                                                                  H.sapiens CL 100 mRNA for protein tyrosine phosphatase, Dual specificity
                     <300>DUSP1           X68277      DUSP1                                                                               0.67164195     23145.6    34461.22 0.31674907     23990.27   75739.05 0.85536516    55302.13
                                                                             phosphatase 1, MKP1
                     <1042>DVL1           U46461      DVL1        Human dishevelled homolog (DVL) mRNA, complete cds.                     0.9084547      1679.76    1849.03    0.9977802    2454.18    2459.64    1.0428054    1533.07

                     <1136>DVL2           NM_004422   DVL2                                                                            0.62725854
                                                                  Homo sapiens dishevelled 2 (homologous to Drosophila dsh) (DVL2), mRNA                  337.44     537.96    0.5495326     245.13     446.07 0.79287773       663.71

                     <1044>DVL3           U49262      DVL3        Human dishevelled (DVL) mRNA, complete cds                              0.6836025       416.02     608.57 0.98013955      1254.02    1279.43 0.68155277       773.91
                                                                  Homo sapiens (E2F-1) pRB-binding protein mRNA; retinoblastoma-binding
                     <738>E2F1            M96577      E2F1                                                                                                                      2.001777     214.03     106.92
                                                                            protein 3 (RBBP3);

                     <927>E2F2            L22846      E2F2        Homo sapiens transcription factor E2F-2 mRNA, complete cds (clone 9).   1.0421145      3146.79    3019.62    1.1184341    6721.14    6009.42    1.0831912    6784.08
Molecular Medicine




                     <425>E2F3            Y10479      E2F3        Homo sapiens E2F transcription factor 3(E2F3)                           0.86034054     3442.36    4001.16    0.8250161    3911.36    4740.95 0.97909594       7645.3
                     <949>E2F4            NM_001950   E2F4        Homo sapiens E2F transcription factor 4, p107/p130-binding (E2F4)       0.7704171      1790.85    2324.52    1.7128628    4517.83    2637.59    1.2359642    7050.36
                     <396>E2F5            U15642      E2F5        Human transcription factor E2F-5 mRNA, complete cds                     0.9512345      1965.26    2066.01    1.7139347     5857.2     3417.4    1.2846837    8659.23

                     <545>EEF1A1          NM_001402   EEF1A1      Homo sapiens eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) 6.363961      64923.16   10201.69   4.7666287    306463.4   64293.53   4.256449    271880.53

                     <48>EGF              X04571      EGF                                                                              0.85223305
                                                                  Human mRNA for kidney epidermal growth factor (EGF) precursor; urogastrone             3008.57    3530.22 0.74420595       608.82     818.08 0.95150566      2462.43

                     <303>EGFR            X00588      EGFR        Human mRNA for precursor of epidermal growth factor receptor            1.9862378       243.91      122.8    0.61135375     131.6     215.26    1.2335021     143.74
                     <248>EGR1            M62829      EGR1        Human transcription factor ETR103 mRNA, complete cds                    0.5423452      4743.85    8746.92     0.599831    2583.46    4306.98    1.4685297    7620.01

                     <238>ELF1            M82882      ELF1                                                                                  0.23743176
                                                                  Human cis-acting sequence; E74-like factor 1 (ets domain transcription factor)          4468.1    18818.46   0.2354234    2078.36    8828.18 0.47283012      7499.35

                     <214>ELF2            U43188      ELF2        Human Ets transcription factor (NERF-2) mRNA, complete cds              0.6788202      1489.99    2194.97 0.84526575      3818.15     4517.1 0.84765625        4811

                     <929>ELK1            AB016193    ELK1                                                                        0.74552083
                                                                  Homo sapiens Elk1 mRNA, complete cds. Member of ETS oncogene family                     622.07     834.41    0.7556816    3348.41    4430.98 0.79910636      3569.76

                     <281>ELL2            U88629      ELL2        ELL-RELATED RNA POLYMERASE II, ELONGATION FACTOR                         1.186129      1363.23    1149.31     1.727502    1644.15     951.75 0.75376594      1327.51
                     <1627>ENTPD3         AF034840    ENTPD3      ectonucleoside triphosphate diphosphohydrolase 3                        1.0827816       642.62     593.49    0.4781704     305.68     639.27    1.2073346     1102.2
                     <369>EP300    U01877      EP300    Human p300 protein mRNA, complete cds                                    1.2501272       9758.08     7805.67   1.3316964    11555.29     8677.12    0.5193667    12398.41




                                                                                                                                                                                                                                    UNCORRECTED PROOF
                     <887>EPHX1    J03518      EPHX1    Human epoxide hydrolase microsomal (xenobiotic) (EPHX1) mRNA             1.2406607        183.32      147.76   0.9319883      363.55      390.08    1.1988443     950.24
                     <736>EPHX2    L05779      EPHX2    Human cytosolic epoxide hydrolase mRNA                                   0.9241237       5692.38     6159.76    1.352738     7817.73     5779.19 0.96560776      3256.01
                     <856>EPO      X02157      EPO      Human mRNA for fetal erythropoietin                                      1.0099345       3993.13     3953.85   1.2052125     8514.32     7064.58    1.2117934    9590.86
                     <741>EPOR     M60459      EPOR     Human erythropoietin receptor mRNA, complete cds                        0.90828013        1568.3     1726.67 0.79889774      1491.55     1867.01 0.66232353      2448.14
                                                        Human tyrosine kinase-type receptor (HER2) mRNA; ERBB2; neu proto-
                     <755>ERBB2    M11730      ERBB2                                                                       1.1290929             1325.86     1174.27 0.85136795      1872.09     2198.92    1.6750362    9807.37
                                                                   oncogene
www.molmed.org




                     <1181>ERBB3   M34309      ERBB3    Human epidermal growth factor receptor (HER3) mRNA (ERBB-3)                                                    1.4142091      158.25       111.9
                     <156>ERBB4    L07868      ERBB4    Homo sapiens receptor tyrosine kinase (ERBB4) gene, complete cds        0.95940775        2280.8      2377.3   1.1541475      2710.7     2348.66    1.0154092     4791.3

                     <988>ERCC1    M13194      ERCC1    Human excision repair protein (ERCC1) mRNA, complete cds, clone pcDE0.92639023           1580.57     1706.16   1.8023475     3218.47     1785.71    1.3918462    3238.52

                     <855>ERCC2    X52221      ERCC2    H.sapiens ERCC2 gene, exons 1 & 2 (partial).                            0.88932085       5458.18     6137.47 0.74821305      7798.58    10422.94    0.8587414    10088.15
                     <434>ERCC3    M31899      ERCC3    Human DNA repair helicase (ERCC3) mRNA, complete cds                    0.87044764         767.7      881.96 0.20041622        98.23      490.13 0.81195784       470.83
                     <172>ESD      AF112219    ESD      Homo sapiens esterase D mRNA                                             2.2361932      14744.43     6593.54   1.8488178    12648.41     6841.35    1.0863008    65139.03
                     <1024>FADD    U24231      FADD     Human Fas-associating death domain-containing protein mRNA              0.51395226         539.1     1048.93 0.65243226       970.78     1487.94    0.8111517    3313.66
                     <660>FAF1     AJ271408    FAF1     Homo sapiens mRNA for Fas-associated factor, FAF1                        0.7955932        384.55      483.35                                        0.88973165    279.18
                                                        Human mRNA for high affinity IgE receptor alpha-subunit (FcERI); Fc fragment of
                     <306>FCER1A   X06948      FCER1A                                                                           0.57865906        3394.2     5865.63   0.7767514    18612.92    23962.52    1.3242182    39601.76
                                                                     IgE, high affinity I, receptor for; alpha polypeptide
                                                        Human Fc-epsilon-receptor gamma-chain mRNA; Fc fragment of IgE, high affinity
                     <742>FCER1G   M33195      FCER1G                                                                            1.9446963       88489.2    45502.84   1.7213858    103860.04   60335.13     1.361849    84579.4
                                                                    I, receptor for; gamma polypeptide
                     <550>FCGR2B   M28696      FCGR2B   Fc fragment of IgG, low affinity IIb, receptor for (CD32)               0.47206625      64923.16    137529.77 0.48413834    56157.45    115994.63   0.8622909    56939.38
                     <1101>FES     X52192      FES      Human C-fes proto-oncogene                                               0.8688626       4916.19     5658.19   1.6467525    16156.75     9811.28    1.2585157    18652.45
                                                        acidic fibroblast growth factor (AFGF) + heparin-binding growth factor 1 precursor
                     <1240>FGF1    X51943      FGF1                                                                                 1.3818551     115.91       83.88   1.4799016      126.28       85.33    3.6620977     376.72
                                                                         (HBGF-1);
                     <803>FGF10    U67918      FGF10    Human keratinocyte growth factor 2 mRNA, complete cds                    0.9368413       2492.71     2660.76   0.8334959     4879.71     5854.51 0.91796964      5629.44

                     <1050>FGF11   U66199      FGF11                                                                          0.7862752
                                                        Human fibroblast growth factor homologous factor 3 (FHF-3) mRNA, complete cds             775.92      986.83   1.1002127      475.71      432.38 0.80025953       980.35

                     <1049>FGF12   U66197      FGF12                                                                           1.871534
                                                        Human fibroblast growth factor homologous factor 1 (FHF-1) mRNA, complete cds              93.82       50.13   1.9128841      130.65        68.3     0.696703     208.99

                     <703>FGF13    U66198      FGF13                                                                          1.1116226
                                                        Human fibroblast growth factor homologous factor 2 (FHF-2) mRNA, complete cds             173.88      156.42                                        1.2365791     347.59

                     <250>FGF2     M27968      FGF2     Human basic fibroblast growth factor (FGF) mRNA (BFGF; FGFB; FGF2) 3.0869012            100953.05   32703.69   2.1080372    72656.96    34466.64    1.9271047    85615.54
                                                        Human fibroblast growth factor 3 (FGF3) ; INT2 proto-oncogene protein precursor;
                     <1139>FGF3    NM_005247   FGF3                                                                             0.88875717        464.82        523    0.65412945      66.61      101.83    1.0409836     1092.2
                                                                     HBGF3
Molecular Medicine




                     <770>FGF4     M17446      FGF4     Human Kaposi's sarcoma oncogene fibroblast growth factor mRNA,complete0.802014
                                                                                                                               cds                818.72     1020.83   1.5024927     2974.68     1979.83    1.1687222    2208.02

                     <546>FGF5     M37825      FGF5     Human fibroblast growth factor-5 (FGF-5) mRNA, complete cds                                                                                         6.0157537      95.47

                     <263>FGF7     M60828      FGF7     Human keratinocyte growth factor mRNA; fibroblast growth factor 7 (FGF-7) 0.772468        886.77     1147.97   0.7676942     1720.61     2241.27    0.9731262    2346.47
                                                        Human fibroblast growth factor 8 (FGF8); androgen-induced growth factor
                     <1041>FGF8    U36223      FGF8                                                                             1.1478956         400.65      349.03   1.1064084     1487.92     1344.82 0.94347525      1868.43
                                                                   precursor (AIGF); HBGF8
                     <617>FGF9     D14838      FGF9     Human mRNA for FGF-9                                                     3.2880764        348.01      105.84   1.0171344      793.67       780.3    0.88657236    1397.3
                     <743>FGFR1    M34641      FGFR1    Human fibroblast growth factor (FGF) receptor-1 mRNA                      1.008218       1693.04     1679.24   0.8593231     2230.33     2595.45 0.73236924      3332.39
                                                        Human keratinocyte growth factor receptor mRNA; fibroblast growth factor receptor
                     <442>FGFR2    M80634      FGFR2                                                                              0.8042446       174.32      216.75   0.3796007       83.85      220.89
                                                                      2 (FGFR2)
                     <1067>FGFR3   M58051      FGFR3    Human fibroblast growth factor receptor (FGFR3) mRNA

                     <1068>FGFR4   L03840      FGFR4    Human fibroblast growth factor receptor 4 (FGFR4) mRNA, complete cds.     1.121307        805.76      718.59   1.4613478     1215.33      831.65 0.23439632       101.21

                     <744>FGR      M19722      FGR      Human fgr proto-oncogene encoded p55-c-fgr protein, complete cds.        0.9406491      64923.16    69019.53 0.59026885     37950.47    64293.53 0.92505324      59087.74
                     <681>FHIT     U46922      FHIT     Human diadenosine triphosphate (Ap3A) hydrolase (FHIT)                   0.6610172       4595.57     6952.27   1.5917714     5989.31     3762.67    2.9369836    4957.54
                                                                Homo sapiens mRNA for growth factor FIGF; C-fos induced growth factor (VEGF
                     <1238>FIGF        Y12863      FIGF                                                                                0.5932941         69.54     117.21
                                                                            D)




                                                                                                                                                                                                                                       UNCORRECTED PROOF
                     <1539>FLJ11190    NM_018354   FLJ11190     hypothetical protein FLJ11190                                           1.0870618      9559.86    8794.22    1.6079291   29988.94   18650.66   1.9787298   67663.81
                                                                Homo sapiens hypothetical protein FLJ14033 similar to hypoxia inducible factor
                     <1390>FLJ14033    NM_022462   FLJ14033                                                                              0.72853494     750.34    1029.93    1.3074573   3320.51    2539.67    0.9051723   10340.39
                                                                           3, alpha subunit
                     <1551>FLJ23322    NM_024955   FLJ23322     hypothetical protein FLJ23322                                           1.2873071         986      765.94    1.3057486    622.15     476.47 0.09468658        17.25
                                                                Human soluble vascular endothelial cell growth factor receptor (sflt) mRNA;
                     <358>FLT1         U01134      FLT1                                                                                   0.56333196    2398.2    4257.17    0.5716662   3114.62    5448.32    0.6516557     4220.8
                                                                            vascular endothelial growth factor receptor 1 (VEGFR1);
www.molmed.org



                     <341>FLT3         U02687      FLT3         Human growth factor receptor tyrosine kinase (STK-1) mRNA; FLK2         0.7351693       950.64    1293.09    0.6639952   2470.64    3720.87    1.1555345    3177.72
                                                                H.sapiens Flt4 mRNA for transmembrane tyrosine kinase; vascular endothelial
                     <841>FLT4         X69878      FLT4                                                                                1.2187207       4880.44    4004.56    1.4889551   6514.73    4375.37    1.207885     9502.77
                                                                             growth factor receptor 3 precursor (VEGFR3)
                                                                Homo sapiens v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS),
                     <392>FOS          NM_005252   FOS                                                                                0.54601973       4290.88    7858.47 0.25052184     9619.14    38396.41   0.5212548     44781
                                                                              mRNA.
                     <51>FOSL1         X16707      FOSL1        Human fra-1 mRNA; FOS-like antigen-1                                  0.94148564         902.8     958.91    1.1978467    734.28       613     1.2120775     546.55
                                                                Homo sapiens frequently rearranged in advanced T-cell lymphomas (FRAT1)
                     <967>FRAT1        NM_005479   FRAT1                                                                             0.6778613         16494.69   24333.43 0.58781374    24788.2    42170.16   1.0275544     65635
                                                                          mRNA
                     <1262>FSHR        M65085      FSHR         Human follicle stimulating hormone receptor mRNA                      0.06819565         10.08     147.81
                                                                Homo sapiens putative tumor suppressor protein unspliced form (Fus-2) mRNA,
                     <78>FUS2          AF040705    FUS2                                                                                0.7076283       1685.33    2381.66 0.84934294      1617.2    1904.06    1.1807796    2809.11
                                                                            complete cds
                                                                FYN oncogene related to SRC, FGR, YES; Homo sapiens c-syn protooncogene
                     <428>FYN          M14333      FYN                                                                                 1.3138924       16592.66   12628.63 0.75707954    9532.57    12591.24   1.2274365   19050.33
                                                                          mRNA;
                     <167>FZD1         AB017363    FZD1         Homo sapiens mRNA for frizzled-1, complete cds                           0.622973       531.72     853.52 0.86218756      147.96     171.61    1.1020845    2233.33

                     <1465>G17         AF244548    G17          transporter protein; system N1 Na+ and H+-coupled glutamine transporter 3.1649354      1176.09      371.6

                     <867>G1P3         X02492      G1P3         Human interferon-inducible mRNA fragment (cDNA 6-16).                 0.12917548       5351.48    41427.98   0.759856    12825.51   16878.87   1.0293236     65748

                     <555>G22P1        M32865      G22P1        Human Ku protein subunit mRNA; Thyroid autoantigen 70kD (Ku antigen) 0.8999707         15939.75   17711.41   0.8385303   14099.35   16814.36   0.8987801    10445.2

                     <415>G3BP         U32519      G3BP         Ras-GTPase-activating protein SH3-domain-binding protein                0.8066791      1891.84    2345.22    0.6101577   3288.14      5389     0.9738595    3290.72
                     <1521>GABARAP     NM_007278   GABARAP      GABA(A) receptor-associated protein                                     1.5039932      64923.16   43167.19   1.1767197   75655.46   64293.53   1.3098179   83664.57
                     <1709>GABARAPL1   BC008891    GABARAPL1 GABA(A) receptor-associated protein like 1                                 0.9690758      9040.77    9329.27 0.47836322     5160.85    10788.56 0.72024107    13576.45
                     <1604>GABARAPL2   BC005985    GABARAPL2 GABA(A) receptor-associated protein-like 2                                 1.7984577      64923.16   36099.35   1.0596423   68128.15   64293.53   1.0329261   65978.11
                     <1708>GABARAPL3   NM_032568   GABARAPL3 GABA(A) receptors associated protein like 3                                1.0881155      20079.81   18453.75   0.4879705   9886.95    20261.37 0.79232544    23812.77
                     <1677>GABBR1      NM_021905   GABBR1       gamma-aminobutyric acid (GABA) B receptor, 1                            1.1909351      13213.08   11094.71   2.6189928   29083.39   11104.8    1.6230739   32560.55
                                                                Homo sapiens GA-binding protein transcription factor, alpha subunit (60kD);
                     <1277>GABPA       NM_002040   GABPA                                                                                  1.2750378     1006.4     789.31    0.6314109   1277.18    2022.74 0.62858355      7324.62
                                                                           nuclear respiratory factor-2
                                                                Homo sapiens GA-binding protein transcription factor, beta subunit 1 (53kD);
                     <1326>GABPB1      NM_005254   GABPB1                                                                                 1.0479254    4873.67    4650.78 0.88620764     4007.36    4521.92    0.9254285    9473.88
Molecular Medicine




                                                                           nuclear respiratory factor-2
                                                                Homo sapiens GA-binding protein transcription factor, beta subunit 2 (47kD);
                     <1350>GABPB2      NM_002041   GABPB2                                                                                0.84514326     793.86     939.32    0.7425974   3255.25     4383.6    0.8156556    5940.33
                                                                           nuclear respiratory factor-2
                     <1625>GABRA1      X14766      GABRA1       gamma-aminobutyric acid (GABA) A receptor, alpha 1                    0.70146865       1726.63    2461.45 0.44057962      640.92    1454.72 0.62241375      3345.25
                     <1652>GABRA2      S62907      GABRA2       gamma-aminobutyric acid (GABA) A receptor, alpha 2                      1.5947912      1110.82     696.53    1.0738068    633.75     590.19    1.4444164    1317.25
                     <1692>GABRA4      U30461      GABRA4       gamma-aminobutyric acid (GABA) A receptor, alpha 4                      0.9118572      1290.36    1415.09    0.8941244    1154.1    1290.76    1.0795808    2318.13
                     <1623>GABRA5      NM_000810   GABRA5       gamma-aminobutyric acid (GABA) A receptor, alpha 5                      2.8737037       429.59     149.49    2.8422973    685.42     241.15    1.130499      2527.4
                     <1651>GABRA6      S81944      GABRA6       gamma-aminobutyric acid (GABA) A receptor, alpha 6                      1.3380667      1284.33     959.84    1.8971196   1470.04     774.88    1.625642     1576.19
                     <1585>GABRB3      NM_021912   GABRB3       gamma-aminobutyric acid (GABA) A receptor, beta 3                       1.0526701      2564.41     2436.1    2.1833673   8102.41    3710.97    1.6059306   14635.97
                     <1456>GABRD       NM_000815   GABRD        gamma-aminobutyric acid (GABA) A receptor, delta                        1.1595505      19433.88   16759.84   1.2534648   25241.95   20137.74   1.1299791   40451.67
                     <1620>GABRE       U66661      GABRE        gamma-aminobutyric acid (GABA) A receptor, epsilon                      0.5751697      5439.65    9457.47 0.87055945     5081.29    5836.81    1.3482382   14424.33
                     <1607>GABRG2      X15376      GABRG2       gamma-aminobutyric acid (GABA) A receptor, gamma 2                      1.4197156       435.37     306.66    0.9976356     324.9     325.67
                     <1660>GABRG3      S82769      GABRG3       gamma-aminobutyric acid (GABA) A receptor, gamma 3                      1.2687597      34034.2    26824.78   1.5569434   53622.63   34440.96   1.8483405   118062.68
                     <1630>GABRP       U95367      GABRP        gamma-aminobutyric acid (GABA) A receptor, pi                           1.1480826       175.14     152.55 0.22338307       17.96       80.4
                     <1700>GABRQ     NM_018558   GABRQ     gamma-aminobutyric acid (GABA) receptor, theta                         0.89292306     6044.75    6769.62    0.7218291    4715.84    6533.18    1.1262672    10899.18




                                                                                                                                                                                                                                  UNCORRECTED PROOF
                     <1533>GABRR2    NM_002043   GABRR2    gamma-aminobutyric acid (GABA) receptor, rho 2                         1.4388794      2414.31    1677.91    1.6099292     1629.2    1011.97    1.5496907     3972.4
                     <1392>GADD34    U83981      GADD34    Homo sapiens apoptosis associated protein (GADD34) mRNA                0.30304274       66.43     219.21                                       0.81043196    692.66

                     <252>GADD45A    M60974      GADD45A   Human growth arrest and DNA-damage-inducible protein (gadd45) mRNA 0.9557601          5768.71    6035.73 0.98188525      4766.13    4854.06    0.8468055    7789.73

                     <1406>GADD45G   NM_006705   GADD45G                                                                    0.99957246
                                                           Homo sapiens growth arrest and DNA-damage-inducible, gamma (GADD45G)                   397.49     397.66    1.3054801     682.74     522.98
                                                                                                                                  2.3766782       123.92      52.14    1.6709336     980.32     586.69    1.2939811     1427.3
www.molmed.org



                     <1043>GAMT      Z49878      GAMT      H.sapiens mRNA for guanidinoacetate N-methyltransferase

                     <637>GAPCENA    AJ011679    GAPCENA   rab6 GTPase activating protein (GAP and centrosome-associated)         1.2407506      14113.91   11375.3    1.0557964    12034.4    11398.41 0.83797306     9249.94
                     <1441>GAS       NM_000805   GAS       Homo sapiens gastrin (GAS)                                             0.7083667       194.73      274.9    0.8169006     285.76     349.81
                     <224>GATA6      U66075      GATA6     Human transcription factor hGATA-6 mRNA, complete cds                  1.1460319        390.9     341.09 0.72232693       233.81     323.69 0.91752815       119.82
                     <1333>GCG       J04040      GCG       Human glucagon mRNA, complete cds                                      0.6223441        383.7     616.54    0.4586339     596.99    1301.67    0.8882148    2136.21
                     <1417>GCGR      L20316      GCGR      Human glucagon receptor mRNA                                           188.77417        58.52       0.31     2.912964     144.25      49.52    1.8314122      284.4
                     <1410>GH2       M38451      GH2       Human placenta-specific growth hormone mRNA                            2.2431595         86.9      38.74    1.3911855     340.91     245.05 0.49503285       191.35
                     <1278>GHR       NM_000163   GHR       Homo sapiens growth hormone receptor (GHR)                             1.1839584        259.5     219.18    1.4516892     110.43      76.07    1.3182248     628.49
                     <1424>GHRHR     NM_000823   GHRHR     Homo sapiens growth hormone releasing hormone receptor (GHRHR)

                     <1437>GHSR      NM_004122   GHSR      Homo sapiens growth hormone secretagogue receptor (GHSR)               0.53395474      136.34     255.34     1.094887     288.01     263.05
                     <429>GJA1       M65188      GJA1      gap junction protein, alpha 1, 43kD (connexin 43)                      0.7285569         229      314.32                                        0.971178     517.23
                     <996>GJA4       M96789      GJA4      gap junction protein, alpha 4, 37kD (connexin 37)                      0.6939952      1698.81    2447.87 0.69678867      1360.25    1952.17 0.60556066       1541.6
                     <682>GJA5       L34954      GJA5      gap junction protein, alpha 5, 40kD (connexin 40)                      1.1573794       676.06     584.13 0.68418837       732.02    1069.91     0.654224    1076.29
                     <936>GJA7       U03493      GJA7      gap junction protein, alpha 7, 45kD (connexin 45)                      1.6416022       197.14     120.09    1.1844833      73.13      61.74    0.8406084     254.78
                                                           gap junction protein, beta 1, 32kD (connexin 32, Charcot-Marie-Tooth
                     <861>GJB1       X04325      GJB1                                                                             0.9557482       1309.7    1370.34    1.1955303     685.29     573.21    1.3003123     545.65
                                                                       neuropathy, X-linked)
                     <1156>GJB2      NM_004004   GJB2      gap junction protein, beta 2, 26kD (connexin 26)

                     <935>GJB3       AF052692    GJB3      gap junction protein, beta 3, 31kD (connexin 31)                       1.4316791         283      197.67    1.1416366      366.1     320.68    1.0507772     444.09
                     <925>GJB5       AF099731    GJB5      gap junction protein, beta 5 (connexin 31.1)                           1.0042361       1913.1    1905.03    0.8487204     391.99     461.86    0.5266326     242.33
                     <174>GJB6       AJ005585    GJB6      gap junction protein, beta 6 (connexin 30)                             1.1801429        82.61        70     0.6540808      85.75      131.1    1.1046745     721.01
                     <1632>GLO1      BC001741    GLO1      glyoxalase I                                                           1.3316065      19025.06   14287.3    1.2218618    19732.52   16149.55   1.2457596    21314.26

                     <1402>GMEB1     NM_006582   GMEB1                                                                           0.7987111
                                                           Homo sapiens glucocorticoid modulatory element binding protein 1 (GMEB1)               382.99     479.51    0.8187568     407.79     498.06    0.8850737     1035.2

                     <1443>GMEB2     NM_012384   GMEB2     Homo sapiens glucocorticoid modulatory element binding protein 2 (GMEB2)1.854902       165.55      89.25    1.2585654     364.77     289.83    0.6663817      358.6
Molecular Medicine




                                                           Human guanine nucleotide-binding regulatory protein (G-y-alpha) mRNA;
                     <754>GNA11      M69013      GNA11                                                                              1.2923045    19115.07   14791.46   2.1537294    40314.37   18718.4    1.1179425    27013.3
                                                                    Guanine nucleotide binding protein (G protein), alpha 11 (Gq class)

                     <747>GNA12      NM_007353   GNA12     Homo sapiens guanine nucleotide binding protein (G protein) alpha 12   1.1890063       237.29     199.57    1.0925684     609.97     558.29    0.6993662     803.32
                                                           Human guanine nucleotide regulatory protein (G13) mRNA; Guanine
                     <1206>GNA13     L22075      GNA13                                                                            0.6797551      5079.13      7472     0.60767424   4196.27    6905.46    0.5182902    5554.35
                                                                  nucleotide binding protein (G protein), alpha 13
                     <365>GNA14      NM_004297   GNA14     Homo sapiens guanine nucleotide-binding protein 14 (GNA14) mRNA        1.4569955       338.97     232.65 0.59749705       247.31     413.91 0.82731074        65.25
                                                           Human G-alpha 16 protein mRNA, complete cds; Guanine nucleotide binding
                     <746>GNA15      M63904      GNA15                                                                          1.0004327        2474.05    2472.98 0.86416185      1603.53    1855.59    1.3205522    2021.99
                                                                   protein (G protein), alpha 15 (Gq class)

                     <1341>GNAQ      NM_002072   GNAQ      Homo sapiens guanine nucleotide binding protein (G protein), q polypeptide0.6722122   1206.52    1794.85 0.28590164      1789.85    6260.37 0.41555932      3988.11
                                                           Homo sapiens guanine nucleotide binding protein (G protein), alpha z
                     <1279>GNAZ      NM_002073   GNAZ                                                                             1.4483371      11484.27   7929.28    0.9204871    3797.35    4125.37 0.82303554      11659.36
                                                                   polypeptide
                                                           Human liver mRNA for beta-subunit signal transducing proteins Gs/Gi (beta-G);
                     <308>GNB1       X04526      GNB1                                                                                0.6615699   25077.37   37905.85 0.53750974     31945.64   59432.67   0.5381442    37067.17
                                                                        Guanine nucleotide binding protein (G protein), beta polypeptide 1

                     <1409>GNB1L     AF238328    GNB1L     Homo sapiens G protein beta-subunit-like polypeptide (GY2)             1.7825798        80.43      45.12    1.6746715     668.06     398.92    1.3830762    1440.46
                                                        Human signal-transducing guanine nucleotide-binding regulatory (G) protein
                                                                                                                                 0.7357567
                                                                  beta subunit mRNA; Guanine nucleotide binding protein (G protein), beta     4284.26    5822.93 0.63965446      5271.06    8240.48    0.8356521     7142.77




                                                                                                                                                                                                                                UNCORRECTED PROOF
                     <1070>GNB2    M16538      GNB2
                                                                            polypeptide 2
                                                        Human MHC protein homologous to chicken B complex protein mRNA;
                     <775>GNB2L1   M24194      GNB2L1                                                                           2.1494985    126275.37   58746.43   2.1019726   135143.23   64293.53   2.0335326    129891.82
                                                                Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
                                                        Human guanine nucleotide-binding protein beta-3 subunit mRNA; Guanine
                     <750>GNB3     M31328      GNB3                                                                           0.6508655       4438.07    6818.72 0.62563926     14296.79    22851.49   0.7057325     9098.48
                                                               nucleotide binding protein (G protein), beta polypeptide 3
                     <1407>GNB4    NM_021629   GNB4     Homo sapiens guanine nucleotide binding protein beta subunit 4       0.39995742         56.31     140.79 0.20603678         67.1     325.67
www.molmed.org



                                                        Homo sapiens G protein beta 5 subunit mRNA; Guanine nucleotide binding
                     <576>GNB5     AF017656    GNB5                                                                            1.1787407       735.77      624.2    0.8273162     440.67     532.65 0.65511304       1494.66
                                                                 protein (G protein), beta 5
                                                        Human G protein gamma-10 subunit mRNA; Guanine nucleotide binding
                     <413>GNG10    U31383      GNG10                                                                           1.1754649     48478.97    41242.38   0.5164597   22377.02    43327.72    0.633577    26544.07
                                                                protein 10
                                                        Human G protein gamma-11 subunit mRNA; Guanine nucleotide binding
                     <1033>GNG11   U31384      GNG11                                                                            2.529719      1607.51     635.45    1.2219821    1747.74    1430.25    1.3951201      6556.8
                                                               protein 11
                     <1442>GNG13   NM_016541   GNG13    Homo sapiens guanine nucleotide binding protein 13, gamma             1.0285256        742.76     722.16    1.3731829    2013.91     1466.6 0.75871116        980.05
                     <1330>GNG2    AF130106    GNG2     Homo sapiens clone FLB4307 PRO1107 mRNA                               1.0285084       3899.95    3791.85 0.40998283      4774.57    11645.78 0.66908026       4609.2
                                                        Homo sapiens guanine nucleotide binding protein (G protein), gamma 3
                     <1007>GNG3    NM_012202   GNG3                                                                          0.86899245         923.4    1062.61    1.6944027     813.11     479.88    1.1935029      988.65
                                                                (GNG3), mRNA
                                                        Homo sapiens clone 24733 mRNA sequence; Guanine nucleotide binding
                     <872>GNG3LG   AF052149    GNG3LG                                                                        0.75220066        575.08     764.53    1.2342843     1434.3    1162.05    1.0855002     1138.82
                                                               protein (G protein), gamma 3, linked
                                                        Human G protein gamma-4 subunit mRNA; Guanine nucleotide binding protein
                     <1032>GNG4    U31382      GNG4              4
                                                        Homo sapiens G protein gamma 5 subunit mRNA; Guanine nucleotide binding
                     <604>GNG5     AF038955    GNG5                                                                          0.68504286      64923.16    94772.41   1.0329062   52954.35    51267.34   1.0869839    47956.56
                                                                 protein (G protein), gamma 5
                                                        Homo sapiens mRNA for G-protein gamma 7; Guanine nucleotide binding
                     <859>GNG7     AB010414    GNG7                                                                           1.1731106       2664.31    2271.15    2.1195154   11763.29    5549.99    1.0984162     7625.93
                                                                protein (G protein), gamma 7
                     <1354>GNL1    NM_005275   GNL1     Homo sapiens guanine nucleotide binding protein-like 1               0.43248862        126.97     293.58    1.035267      121.53     117.39    0.77062076    1317.33
                                                        Human placenta mRNA for luteinizing hormone releasing hormone precursor
                     <1269>GNRH1   X01059      GNRH1                                                                           1.001512        516.62     515.84 0.89290744      2141.21    2398.02    1.2269974     1851.76
                                                                  (LHRH).
                     <1547>GPR24   BC001736    GPR24    G protein-coupled receptor 24                                          2.122953       14994.8    7063.18    3.036654    27799.23    9154.56    2.5837266    29766.83
                     <1495>GPX1    X13710      GPX1     glutathione peroxidase 1                                              1.3301352       17110.3    12863.58    1.46049    18187.19    12452.8    1.5683687    26794.15
                     <1486>GPX2    X68314      GPX2     Glutathione peroxidase 2 (gastrointestinal)                            2.278106        354.61     155.66    1.0867802     841.07     773.91 0.55667824        372.44
                     <1553>GPX3    X58295      GPX3     glutathione peroxidase 3 (plasma)                                     0.6423355       2335.05    3635.25    1.4813409    6453.21    4356.33    1.1768026      8361.9
                     <1461>GPX4    X71973      GPX4     glutathione peroxidase 4 (phospholipid hydroperoxidase)               2.0096684       3444.23    1713.83    2.7544951   11039.63    4007.86    1.2767646    27483.84
                     <1303>GRB10   NM_005311   GRB10    Homo sapiens growth factor receptor-bound protein 10 (GRB10), mRNA    1.2089677       2925.98    2420.23    0.8595152    2766.04    3218.14    1.1013658     2681.22
                                                        Homo sapiens epidermal growth factor receptor-binding protein GRB2 (EGFRBP-
                     <433>GRB2     M96995      GRB2                                                                           1.0449631      29215.76    27958.65 0.57269794     23100.7    40336.62    0.716446    45762.96
                                                                   GRB2) mRNA sequence
Molecular Medicine




                     <1263>GRLF1   M73077      GRLF1    Human glucocorticoid receptor repression factor 1 (GRF-1) mRNA       0.68151057         256.8     376.81    0.393116      136.14     346.31

                     <323>GRO1     X12510      GRO1     Human mRNA for melanoma growth stimulatory activity (MGSA), groucho 0.6307762          2271.4    3600.96 0.22499533       906.54    4029.15    0.5325506     7752.52
                                                        Human mRNA for macrophage inflammatory protein-2alpha (MIP2alpha,; GRO2
                     <324>GRO2     X53799      GRO2                                                                        0.59205115         1095.49    1850.33                                       0.32520774     218.39
                                                                  oncogene
                                                        Human protein kinase mRNA; glycogen synthase kinase 3 beta (GSK3 beta); tau
                     <501>GSK3B    L33801      GSK3B                                                                         0.9727429        6978.38    7173.92    0.6562871   11230.91    17112.8 0.91277236      29645.87
                                                                    kinase subunit; factor A

                     <596>GSPT1    X17644      GSPT1                                                                         1.6236362
                                                        Human GST1-Hs mRNA for GTP-binding protein; G1 to S phase transition 1               86260.97    53128.26   3.2385092   154843.17   47813.1 0.59973264       38307.9

                     <1665>GSR     X15722      GSR      glutathione reductase                                                 0.9183039       2995.59    3262.09    0.7796433    1396.77    1791.55 0.88937044       5632.97
                     <8>GSS        NM_000178   GSS      Homo sapiens glutathione synthetase                                   0.9381295        666.86     710.84    0.9538082    1536.69    1611.11    1.4849637      1200.4
                     <436>GSTA2    M21758      GSTA2    Human glutathione S-transferase A2 (GSTA2) mRNA                       0.4858286        131.13     269.91                                       0.6814627       32.24
                     <826>GSTA3    AF020919    GSTA3    Homo sapiens glutathione transferase (GSTA3) mRNA, partial cds        1.0940417        342.26     312.84
                     <132>GSTA4    AF020918    GSTA4    Homo sapiens glutathione transferase (GSTA4) mRNA, complete cds      0.96511066        518.94      537.7    1.0071254    1102.49    1094.69    1.0714273     1920.63
                     <1071>GSTM1   J03817      GSTM1    Human glutathione transferase M1B (GST1) mRNA                         0.6110416       3219.45    5268.79    3.5235274   17684.02    5018.84    1.4067813     5167.15
                     <749>GSTM2    M63509      GSTM2    Human glutathione transferase M2 (GSTM2) mRNA                        0.51512975       1120.33    2174.85    2.9946783    13015.8    4346.31    1.3726629     6013.17
                     <437>GSTM3       J05459      GSTM3      Human glutathione transferase M3 (GSTM3) mRNA                           1.0443336       2042.8    1956.08    1.348936     2540.64    1883.44    0.8061388     4298.51




                                                                                                                                                                                                                                      UNCORRECTED PROOF
                     <1506>GSTM4      BC015513    GSTM4      glutathione S-transferase M4                                           0.91440374      9250.94    10116.91   1.9154674   14474.67    7556.73    1.5499015    11754.05
                     <976>GSTM5       L02321      GSTM5      Human glutathione S-transferase (GSTM5) mRNA                            0.3629678       222.59     613.25    7.3371487     551.24      75.13    1.3321276       736.6
                     <1106>GSTP1      X06547      GSTP1      Human mRNA for class Pi glutathione S-transferase                       1.0817322      1569.02    1450.47    1.4414777    8527.19    5915.59     1.630234    11768.74
                     <975>GSTT1       X79389      GSTT1      H.sapiens GSTT1 mRNA                                                    1.1277308       915.74     812.02 0.86054885       705.28     819.57    0.1877315      335.02
                     <994>GSTT2       L38503      GSTT2      Homo sapiens glutathione S-transferase theta 2 (GSTT2) mRNA              1.450752       342.45     236.05    1.8771068      267.3      142.4
www.molmed.org



                     <1611>GSTTLp28   BC000127    GSTTLp28   glutathione-S-transferase like; glutathione transferase omega           1.9867638      66893.69   33669.67   2.099888    97392.95    46380.07    1.715922    109604.45
                     <802>GSTZ1       U86529      GSTZ1      Human glutathione transferase Zeta 1 (GSTZ1) mRNA, complete cds.         0.616177      1225.04    1988.13    2.0156376    4029.32    1999.03    1.2075855      2826.1
                     <906>GTF2F1      X64037      GTF2F1     general transcription factor IIF, polypeptide 1 (74kD subunit)           0.917245      4618.64    5035.34    1.075556     9712.69    9030.39    1.2071105     5541.41
                                                             Human Hanukah factor serine protease (HuHF) mRNA (cytotoxic T-lymphocyte-
                     <438>GZMA        M18737      GZMA                                                                              3.62717         11788.81   3250.14    1.5141021   20033.01    13230.95    5.153718    47039.89
                                                                         associated serine esterase 3)
                                                             Human serine esterase (HSE26.1) mRNA; Granzyme B (granzyme 2, cytotoxic T-
                     <727>GZMB        J04071      GZMB                                                                           2.1260579            47.73      22.45    8.305897      142.28      17.13    0.3513164      100.48
                                                                           lymphocyte-associated serine esterase 1)

                     <1323>H11        AF250138    H11                                                                                 1.3117274
                                                             Protein kinase H11;Homo sapiens small stress protein-like protein HSP22 mRNA            318.33     242.68    1.1559634      201.6      174.4

                     <1014>HABP2      D49742      HABP2                                                                             0
                                                             Human mRNA for HGF activator like protein (hyaluronan-binding protein 2) .75121695       72.53      96.55                                         0.58587      160.71
                                                             Homo sapiens amyloid beta-peptide binding protein (ERAB) mRNA; Hydroxyacyl-
                     <816>HADH2       U96132      HADH2                                                                           1.2354921         4235.44    3428.14    1.524787     4630.29    3036.68    1.3526434     4988.17
                                                                        Coenzyme A dehydrogenase, type II
                     <1540>HAGH       BC002627    HAGH       hydroxyacyl glutathione hydrolase                                        1.326728      22721.25   17125.78   3.4484136   23812.85    6905.45    1.2820163     48337.4
                     <423>HDAC1       D50405      HDAC1      Human mRNA for RPD3 protein, Histone deacetylase 1                      1.0839194      17542.13   16183.98   1.3200513   84239.35    63815.21    1.336068    84687.95
                     <507>HDGF        D16431      HDGF       Human mRNA for hepatoma-derived growth factor, complete cds             1.5884056      33729.73   21234.96   2.261841     63760.1    28189.47   0.9650753    61644.15
                                                             Homo sapiens homocysteine-inducible, endoplasmic reticulum stress-inducible,
                     <1324>HERPUD1    NM_014685   HERPUD1                                                                           0.6534205       64923.16   99358.93 0.76308715    42184.23    55281.01   0.9262639     33900.4
                                                                        ubiquitin-like domain member 1

                     <439>HGF         M60718      HGF                                                                                3.119984
                                                             Human hepatocyte growth factor mRNA (HGF); scatter factor (SF); hepatopoeitin A        2994.28     959.71    3.041895     5840.56    1920.04    1.7199368     4626.51

                     <1093>HGFAC      D14012      HGFAC      Human mRNA for hepatocyte growth factor (HGF) activator precursor                                            4.172983       42.94      10.29    0.13165605      23.81
                                                             Homo sapiens hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix
                     <1280>HIF1A      NM_001530   HIF1A                                                                                 0.7216662   6546.09     9070.8 0.42541048      9385.47    22062.15   0.4944347    18842.61
                                                                        transcription factor)
                                                             Homo sapiens protein kinase C inhibitor (PKCI-1) mRNA, Histidine triad
                     <687>HINT        U51004      HINT                                                                                  3.0824826   4953.58    1607.01    3.7379484    7368.58    1971.29     2.007549     8815.47
                                                                       nucleotide-binding protein
                     <444>HLA-DRA     K01171      HLA-DRA    Human HLA-DR alpha-chain mRNA; Class II MHC alpha                       1.4714954      64923.16   44120.53   3.191839    205214.6    64293.53   1.6940787    108209.21
                     <850>HLA-DRB1    X02902      HLA-DRB1   Human mRNA for HLA class II DR-beta 1 (Dw14); Class II MHC beta         0.8860695      47707.37   53841.57   2.082479    133889.92   64293.53     1.67739    107143.22
                     <776>HLA-DRB5    M11867      HLA-DRB5   Human MHC class II HLA DR5 DR-beta-chain mRNA, complete cds             0.7023497      14300.69   20361.21   1.8296828   65119.64    35590.67   1.5067343    96242.59
                                                                                                                                     1.1131992      64923.16   58321.24   1.0725627   68958.84    64293.53    1.788869    114263.94
Molecular Medicine




                     <1524>HLA-G      M32800      HLA-G      HLA-G histocompatibility antigen, class I, G
                                                             Homo sapiens heat shock protein hsp40 homolog mRNA, complete cds; DnaJ-
                     <384>HLJ1        U40992      HLJ1                                                                           0.9833169           318.28     323.68
                                                                       like heat shock protein 40
                     <597>HMG1        X12597      HMG1       Human mRNA for high mobility group-1 protein (HMG-1).                    2.295179      26840.51   11694.3    1.0186905   30352.85    29795.95   2.0057745    40415.55
                     <689>HMGCL       U49719      HMGCL      Human hydroxymethylglutaryl-CoA lyase (HMGCL) gene                      1.0940846      2515.76    2299.42    0.8319414    3407.79    4096.19    1.2463905     4419.09
                     <879>HNK-1ST     AF070594    HNK-1ST    Homo sapiens clone 24570 HNK-1 sulfotransferase mRNA                    1.7351305       261.97     150.98    0.7594111     258.42     340.29    1.0084512      329.34
                     <362>HNMT        U08092      HNMT       Human histamine N-methyltransferase (HNMT) mRNA                         1.4868591        404.5     272.05    1.1944684    1360.38     1138.9    1.2047749     1441.73
                     <1640>HPGD       NM_000860   HPGD       hydroxyprostaglandin dehydrogenase 15-(NAD)                             0.9574069      2867.29    2994.85    1.047651     5635.86    5379.52    1.3012273     8461.92

                     <28>HRAS         NM_005343   HRAS                                                                           1.0533655
                                                             Homo sapiens v-Ha-ras Harvey rat sarcoma viral oncogene homolog (HRAS)                  763.69       725     1.6427256     704.45     428.83    1.2146093       670.1

                     <1586>HRH1       NM_000861   HRH1       histamine receptor H1                                                   1.1686999       183.93     157.38                                       0.8398229      561.43
                     <1513>HRH2       NM_022304   HRH2       histamine receptor H2                                                   1.2154347      1605.65    1321.05    1.657981     2053.94    1238.82    1.3360982     3071.77
                     <1514>HRH3       NM_007232   HRH3       histamine receptor H3                                                   0.7387003      2273.69    3077.96 0.76086307       1654.9    2175.03    0.7027748      560.73
                     <1701>HRH4       NM_021624   HRH4       histamine H4 receptor                                                   1.2756624      11095.75   8698.03    1.3139261   11478.13    8735.75 0.99072593        8249.2
                                                               Homo sapiens activator of apoptosis Hrk (HRK) mRNA; Harakiri, BCL2-interacting
                     <792>HRK          U76376      HRK                                                                               0.64666957      3166.12    4896.04    1.0737745   5459.08    5084.01    1.015627     5105.1
                                                                            protein (contains only BH3 domain)




                                                                                                                                                                                                                                    UNCORRECTED PROOF
                                                               Homo sapiens, Similar to histamine N-methyltransferase, clone MGC:14500
                     <1613>Hs.14438    BC005907    Hs.14438                                                                           1.2118255      4700.32    3878.71    1.3569614   6266.38    4617.95    1.5947388   8059.06
                                                                          IMAGE:4249496, mRNA, complete cds
                     <1688>Hs.240767   BC014320    Hs.240767   Similar to Unknown (protein for MGC:19209)                             1.500046        977.82     651.86    0.5630128    419.27     744.69 0.54235417      701.79
                                                               Homo sapiens cDNA FLJ32276 fis, clone PROST2000105, moderately similar to
                     <1518>Hs.350746   AK056838    Hs.350746                                                                      1.0288349          14921.82   14503.61   1.1320434   24151.59   21334.51   1.1821014   54450.84
                                                                         CALPAIN 2, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17)
                                                               Homo sapiens cDNA FLJ30648 fis, clone CTONG2006449, moderately similar
www.molmed.org



                     <1713>Hs.351290   AK055210    Hs.351290                                                                        1.1293834
                                                                         to Drosophila melanogaster 26S proteasome regulatory complex subunit p42A   9255.41     8195.1    0.9072419   9394.58    10355.1    1.0221452   22424.22
                                                                                     mRNA
                     <1471>HSA9947     NM_022089   HSA9947     putative ATPase                                                       0.9726907        348.34     358.12    2.7769222    259.67      93.51    0.9717102   3335.24
                                                               Homo sapiens heat shock factor binding protein 1 HSBP1 mRNA; Heat shock
                     <603>HSBP1        AF068754    HSBP1                                                                             1.842972        9715.54    5271.67    1.253878    19165.1    15284.66   1.4141058   20688.41
                                                                          factor binding protein 1

                     <907>HSC40        AF088982    HSC40       Homo sapiens heat shock protein hsp40-3 mRNA; Heat shock cognate 40 1.1201979          172.04     153.58    1.0887053    275.29     252.86    1.1642299    246.06

                     <1382>HSD11B2     NM_000196   HSD11B2     Homo sapiens hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2)       1.7664332        272.49     154.26    2.8909724    672.18     232.51    1.4440517   1237.87
                                                               Homo sapiens hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-
                     <1342>HSD3B1      NM_000862   HSD3B1                                                                               1.2326134    1939.32    1573.34    1.4719541   1972.08    1339.77    1.3782532   1383.78
                                                                             isomerase 1 (HSD3B1)
                                                               Human heat shock factor 1 (TCF5) mRNA, complete cds; Heat shock transcription
                     <757>HSF1         M64673      HSF1                                                                                0.93509495     299.38     320.16    0.968673     643.78      664.6    0.7505035   1445.92
                                                                               factor 1
                                                               Human heat shock factor 2 (HSF2) mRNA, complete cds; Heat shock transcription
                     <257>HSF2         M65217      HSF2                                                                                 1.6396329    2585.98    1577.17 0.86945045     4541.67    5223.61    1.1930182   5110.21
                                                                               factor 2
                                                               Homo sapiens mRNA for HSF2BP; Heat shock transcription factor 2 binding
                     <605>HSF2BP       AB007131    HSF2BP                                                                               2.5408163      149.4       58.8    0.7624544    430.68     564.86    0.5072221    282.33
                                                                            protein
                                                               Homo sapiens mRNA for heat shock transcription factor 4; Heat shock transcription
                     <1064>HSF4        D87673      HSF4                                                                                0.69027764     312.04     452.05 0.92831147      219.36      236.3
                                                                                factor 4
                                                               Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds; Heat
                     <590>HSJ2         L08069      HSJ2                                                                                   2.51817    24716.67   9815.33    1.0165083   21051.35   20709.47   1.0726762   43725.49
                                                                            shock protein, DNAJ-like 2
                                                               Molecular cloning, expression and localization of human 105 kDa heat shock
                     <168>HSP105B      AB003333    HSP105B                                                                              1.0136725     725.83     716.04    1.2402217   1906.01    1536.83 0.85738003     6449.23
                                                                           protein, hsp105D
                     <506>HSPA10       NM_006597   HSPA10      Homo sapiens heat shock 70kD protein 10 (HSC71) (HSPA10), mRNA        1.9605367       68654.31   35018.12   1.3537452   77418.66   57188.5    1.1257675   71908.35
                                                               Homo sapiens heat shock 70kD protein 1 (HSPA1A), mRNA; Heat shock 70kD
                     <983>HSPA1A       NM_005345   HSPA1A                                                                         0.63118356         64923.16   102859.4   0.7202702   32366.33   44936.37   0.8314935   31319.63
                                                                          protein 1
                     <653>HSPA1B       NM_005346   HSPA1B      Homo sapiens heat shock 70kD protein 1 (HSPA1B), mRNA                   0.72976       15360.31   21048.44   0.7747142   15893.51   20515.32   1.073682    33238.55
                                                               Homo sapiens HSPA1L mRNA for Heat shock protein 70 testis variant, complete
                     <475>HSPA1L       D85730      HSPA1L                                                                            0.9187732       15301.91   16654.72   0.8660368   7570.14    8741.13    0.8487425   6321.85
                                                                          cds; Heat shock 70kD protein-like 1

                     <344>HSPA2        U56725      HSPA2       Human heat shock protein mRNA, complete cds; Heat shock 70kD protein0.76759714
                                                                                                                                    2                 592.04     771.29 0.76393116      645.01     844.33    0.7328832    1036.7

                     <139>HSPA4        L12723      HSPA4       Human heat shock protein 70 (hsp70) mRNA; Heat shock 70kD protein 4 1.4313275         9279.11    6482.87 0.99469775     5256.56    5284.58 0.81407034     5052.56
Molecular Medicine




                                                               H.sapiens mRNA for BiP protein; Heat shock 70kD protein 5 (glucose-regulated
                     <512>HSPA5        X87949      HSPA5                                                                               0.6515309     18987.67   29143.16 0.83039993    59318.87   71434.1    0.7673833   49016.58
                                                                           protein, 78kD)

                     <897>HSPA6        X51758      HSPA6       Human mRNA for heat shock protein HSP70B'; Heat shock 70kD protein 60.43241516        12530.76   28978.54 0.73085177    23315.43   31901.72   0.7576192   48392.9
                                                               Homo sapiens mitochondrial HSP75 mRNA; Heat shock 70kD protein 9B
                     <586>HSPA9B       L15189      HSPA9B                                                                             1.288266       2775.35    2154.33    0.8391106   1630.35    1942.95    0.8489791   7318.31
                                                                        (mortalin-2)

                     <1108>HSPB1       X54079      HSPB1       Human mRNA for heat shock protein HSP27; Heat shock 27kD protein 1 1.0233785          5009.99    4895.54    1.9272352   12277.24   6370.39    1.5212082   30386.97

                     <824>HSPB2        D89617      HSPB2       Homo sapiens mRNA for MKBP; Heat shock 27kD protein 2                0.94265145        401.89     426.34 0.18475488       26.08     141.16 0.18316555       35.84
                                                               Homo sapiens heat shock 17kD protein 3 (HSPB3) mRNA, complete cds; Heat
                     <932>HSPB3        U15590      HSPB3                                                                             0.7216947        161.14     223.28 0.41895446      140.09     334.38 0.63632226      111.77
                                                                          shock 27kD protein 3
                                                               Homo sapiens mRNA for cardiovascular heat shock protein; Heat shock 27kD
                     <1001>HSPB7       AJ243191    HSPB7                                                                             0.9895292        991.35    1001.84    1.549916     719.44     464.18    1.1531566    650.98
                                                                          protein family, member 7 (cardiovascular)
                     <1697>HSPC228     AF271994    HSPC228     hypothetical protein                                                   1.328731       2591.57    1950.41    1.4011914   2933.59    2093.64    0.9813882   12022.82

                     <150>HSPCA        AF028832    HSPCA                                                                            4.6580367
                                                               Homo sapiens Hsp89-alpha-delta-N mRNA; Heat shock 90kD protein 1, alpha               15900.58   3413.58    1.5112925   40611.24   26871.86   1.5571934   45573.93

                     <440>HSPCB        M16660      HSPCB                                                                              0.729319
                                                               Human 90-kDa heat-shock protein gene, cDNA; Heat shock 90kD protein 1, beta           11457.9    15710.41   1.2207257   33206.46   27202.23   1.1477778   21091.61
                     <258>HSPD1     M34664      HSPD1    Heat shock 60kD protein 1 (chaperonin)                                 1.2259411      30553.65   24922.61   1.1922075   76651.23   64293.53    1.0045834    53937.53




                                                                                                                                                                                                                                 UNCORRECTED PROOF
                     <639>HSPE1     U07550      HSPE1    Human chaperonin 10 mRNA; Heat shock 10kD protein 1                    2.5978165      11399.4     4388.07   2.6400795   26822.76   10159.83    2.2667952    18914.84
                     <1010>HSPF1    D49547      HSPF1    Human mRNA for heat-shock protein 40; Heat shock 40kD protein 1        1.1463141      25565.19   22302.08 0.91693413    11803.95   12873.28    0.7847221    21412.46
                                                         Homo sapiens DnaJ protein (HSPF2) mRNA, complete cds; Heat shock 40kD
                     <818>HSPF2     AF012106    HSPF2                                                                      0.85680276           737.87      861.19   0.4988995    240.27       481.6    1.9205822      642.55
                                                                    protein 2
                     <1502>HTR1A    NM_000524   HTR1A    5-hydroxytryptamine (serotonin) receptor 1A                           0.80836165      4856.75     6008.14   1.9050041   16224.71    8516.89    1.8466247    27280.15
                     <1535>HTR1B    M81590      HTR1B    5-hydroxytryptamine (serotonin) receptor 1B                            1.0854207       383.49      353.31   38.221584    201.81        5.28    1.4646056      848.49
www.molmed.org




                     <1587>HTR1E    NM_000865   HTR1E    5-hydroxytryptamine (serotonin) receptor 1E                            1.2816771      12979.62   10127.06   1.2610542   12126.31    9616.01    1.1777204    33459.11
                     <1704>HTR2A    X57830      HTR2A    5-hydroxytryptamine (serotonin) receptor 2A                            1.5353214      3006.85     1958.45   1.9628175   3880.51     1977.01    1.9374751    13388.03
                     <1626>HTR2C    U49516      HTR2C    5-hydroxytryptamine (serotonin) receptor 2C                            3.3129337       802.26      242.16 0.20545125      72.89      354.78    0.9947598      288.55
                     <1592>HTR3A    BC002354    HTR3A    5-hydroxytryptamine (serotonin) receptor 3A                            1.2798438      1405.87     1098.47   1.0434387    882.05      845.33
                     <1662>HTR4     AJ131724    HTR4     5-hydroxytryptamine (serotonin) receptor 4                             1.7474376      1981.07      1133.7   1.1991651    1959.1     1633.72    1.0271568     4397.32
                     <1503>HTR5A    NM_024012   HTR5A    5-hydroxytryptamine (serotonin) receptor 5A                           0.25755867      1170.63      4545.1   1.1916001     1969       1652.4    0.7950026     2515.73
                     <1462>HTR6     NM_000871   HTR6     5-hydroxytryptamine (serotonin) receptor 6                              2.115629      47155.76   22289.24   2.1000164   31342.47   14924.87    2.3038926    143172.16
                     <760>ICAM1     J03132      ICAM1    Human intercellular adhesion molecule-1 (ICAM-1) mRNA, CD54           0.63417345       575.69      907.78 0.24873038     217.46      874.28    0.8656086     4134.32
                                                         Homo sapiens DNA-binding protein mRNA (Interferon consensus sequence
                     <807>ICSBP1    M91196      ICSBP1                                                                       0.7607338         1557.96     2047.97 0.71595937    3648.93     5096.56 0.89352846       5327.44
                                                                   binding protein 1)
                     <371>IFI16     NM_005531   IFI16    Homo sapiens interferon, gamma-inducible protein 16 (IFI16) mRNA      0.46955463      14457.84   30790.54 0.47305042    16650.41   35197.96     0.574849    22409.35
                     <895>IFI27     X67325      IFI27    H.sapiens p27 mRNA (interferon, alpha-inducible protein 27)           0.10928562      2244.15    20534.72   3.2384396   9071.29     2801.13 0.64515626       20545.4

                     <762>IFI30     J03909      IFI30    Human gamma-interferon-inducible protein (IP-30) mRNA, complete cds    0.7399266      41191.04   55669.09 0.98259866    19149.68   19488.81    1.4830936    90989.62

                     <310>IFIT1     X03557      IFIT1    Human mRNA for 56-KDa protein induced by interferon                   0.13978992      3180.65    22753.07 0.30263293    8408.28    27783.76    0.4785495    24834.14
                                                         Homo sapiens interferon induced tetratricopeptide protein IFI60 (IFIT4) mRNA,
                     <481>IFIT4     AF083470    IFIT4                                                                             0.13565682   4678.71    34489.31 0.30410945    9605.75    31586.49 0.77952814      33943.78
                                                                    complete cds
                     <711>IFITM1    J04164      IFITM1   Human interferon-inducible protein 9-27 mRNA, complete cds             0.6033064      64923.16   107612.25 0.50277334   52784.63   104986.93   1.0153435    64855.03
                     <853>IFITM3    X57352      IFITM3   Human 1-8U gene from interferon-inducible gene family                 0.52801645      11268.97   21342.08   0.5915814   16929.02   28616.55 0.66174495       9880.13
                     <868>IFNA13    V00538      IFNA13   Messenger RNA for human leukocyte (alpha) interferon

                     <601>IFNA14    V00542      IFNA14   Messenger RNA for human leukocyte (alpha) interferon                   2.2191541       382.56      172.39   2.2683294    707.56      311.93    0.77985036     694.02

                     <1183>IFNA16   M28585      IFNA16   Human leukocyte interferon-alpha mRNA, complete cds, clone pIFN105 0.50650805         1758.52     3471.85 0.49706233    2187.78     4401.42    0.6266777     3454.21

                     <1196>IFNA21   V00540      IFNA21   Messenger RNA for human leukocyte (alpha) interferon                   2.6161003       185.56       70.93
                     <600>IFNA5     V00541      IFNA5    Messenger RNA for human leukocyte interferon (one of eight).           1.0467132       707.62      676.04   0.9085827   1428.61     1572.35 0.87649167       1007.72
Molecular Medicine




                     <1197>IFNA8    V00550      IFNA8    Messenger RNA for human leukocyte (alpha) interferon.                 0.77284634        300.9      389.34   1.1811308     229.6      194.39    1.1976428       453.2

                     <104>IFNAR1    J03171      IFNAR1   Human interferon-alpha receptor (HuIFN-alpha-Rec) mRNA, complete cds0.71834546        7777.21    10826.56   0.5515184   6738.11    12217.38 0.74726814      18462.03

                     <367>IFNAR2    X77722      IFNAR2   H.sapiens mRNA for interferon alpha/beta receptor                      1.0537282      25478.59   24179.47   1.1442388   28630.56   25021.49    0.8894139    20424.92
                     <1258>IFNB1    V00547      IFNB1    Human messenger RNA for fibroblast (beta) interferon                    1.136578       599.92      527.83   0.9769967    526.23      538.62    0.9091765      414.93
                     <311>IFNG      X13274      IFNG     Human mRNA for interferon IFN-gamma                                    1.1328324      3640.21     3213.37   1.6046654   5274.84     3287.19    1.9342995     4934.05
                     <105>IFNGR1    J03143      IFNGR1   Human interferon-gamma receptor mRNA, complete cds                     1.7898964      23225.14   12975.69 0.56857866    24801.97     43621     0.99210346   30784.88
                                                         Human clone pSK1 interferon gamma receptor accessory factor-1 (AF-1) mRNA,
                     <493>IFNGR2    U05875      IFNGR2                                                                         1.1911273       44918.48    37710.9   0.6247158   38723.21   61985.32 0.93971276       55277.7
                                                                      complete cds
                     <1198>IFNW1    X02669      IFNW1    Human mRNA for type 1 interferon-omega 1.

                     <443>IGBP1     Y08915      IGBP1    Immunoglobulin (CD79A) binding protein 1                               2.9781206      7406.02     2486.81   1.4408765   3773.67     2619.01    1.5905534     7075.29
                     <1200>IGF1     X57025      IGF1     Human IGF-I mRNA for insulin-like growth factor I                      0.8271324       920.83     1113.28   1.3077271   4347.97     3324.83    1.4088987     9086.65
                     <470>IGF1R     X04434      IGF1R    Human mRNA for insulin-like growth factor I receptor                   0.6158924       881.65      1431.5 0.47428623    1233.59     2600.94    1.3722215      2004.5
                     <25>IGF2       J03242      IGF2     Human insulin-lke growth factor II mRNA, complete cds                  1.1775777      1289.53     1095.07   1.1389364    452.75      397.52
                     <1580>IGFALS    NM_004970   IGFALS    insulin-like growth factor binding protein, acid labile subunit               0.86185133     826.3     958.75     1.911749      534.2     279.43     1.29269    1014.71




                                                                                                                                                                                                                                      UNCORRECTED PROOF
                     <1180>IGFBP1    M31145      IGFBP1    Human insulin-like growth factor binding protein mRNA, complete cds           1.3097832     206.71     157.82    1.0281107     355.86     346.13
                     <1061>IGFBP2    M35410      IGFBP2    Human insulin-like growth factor binding protein 2 (IGFBP2) mRNA              1.6756743     342.91     204.64    2.1577837     480.97      222.9    1.6619861    312.47
                                                           Human growth hormone-dependent insulin-like growth factor-binding protein
                     <547>IGFBP3     M31159      IGFBP3                                                                            1.2808714          1243.06     970.48    1.0624319    1305.41     1228.7    1.3240232   10291.13
                                                                    mRNA, complete cds

                     <761>IGFBP4     M62403      IGFBP4                                                                            1.0158668
                                                           Human insulin-like growth factor binding protein 4 (IGFBP4) mRNA, complete cds              359.82      354.2    1.1460133    1603.33    1399.05    0.7443173   1825.87
www.molmed.org



                     <1076>IGFBP6    M62402      IGFBP6                                                                           0.83795893
                                                           Human insulin-like growth factor binding protein 6 (IGFBP6) mRNA, complete cds               95.41     113.86    0.72375983    271.96     375.76 0.04031773       24.77
                                                           prostacyclin-stimulating factor [human, cultured diploid fibroblastcells, mRNA, 1124
                     <407>IGFBP7     S75725      IGFBP7                                                                                  1.031906     4430.21    4293.23    0.9723701    8222.74    8456.39    1.7796336   10912.82
                                                                           nt].
                                                           Homo sapiens IkappaB kinase complex associated protein (IKAP) mRNA,
                     <165>IKBKAP     AF044195    IKBKAP                                                                                0.84610814      712.22     841.76    1.0584818    3153.99    2979.73    1.058651    13918.72
                                                                        complete cds; IKKAP2
                     <934>IKBKB      AF080158    IKBKB     Homo sapiens IkB kinase-b (IKK-beta) mRNA, IKK2/beta; IKK2                    0.9545974    1603.59    1679.86    0.9587363    1114.09    1162.04    0.8632151   1674.62
                     <912>IKBKG      AF074382    IKBKG     Homo sapiens IkB kinase gamma subunit (IKK-gamma) mRNA, NLK                   0.70085067   8468.75    12083.53   0.9273939    14413.51   15541.95   1.0177238   15392.93
                     <1252>IL10      M57627      IL10      Human interleukin 10 (IL10) mRNA                                               1.009662     470.24     465.74    0.9727002     459.63     472.53 0.44197598       169.9
                     <494>IL10RA     U00672      IL10RA    Human interleukin-10 receptor mRNA, complete cds                              0.99051714   28401.97   28673.88 0.99988097     63271.61   63279.14   1.1373183   50310.92
                     <620>IL10RB     Z17227      IL10RB    Homo sapiens mRNA for transmebrane receptor protein                           0.5824725    4786.13    8216.92 0.44383445      6394.23    14406.79   0.6392913   22224.22
                     <763>IL11       M57765      IL11      Human interleukin 11 mRNA, complete cds                                       0.9396184    2747.51    2924.07     1.489811    2470.33    1658.15 0.84713423     4535.32
                     <1031>IL11RA    Z38102      IL11RA    H.sapiens mRNA for interleukin-11 receptor                                    1.0007393     2030.4     2028.9    2.1733332     9920.2    4564.51    1.3884779   5854.92

                     <561>IL12A      M65291      IL12A                                                                               1.0761487
                                                           Human natural killer cell stimulatory factor (NKSF) mRNA, complete cds, clone p35           191.35     177.81    1.0304904     810.46     786.48    1.1454272    885.61

                     <1257>IL12B     M65290      IL12B                                                                               1.0123594
                                                           Human natural killer cell stimulatory factor (NKSF) mRNA, complete cds, clone p40           309.62     305.84 0.72581154       365.33     503.34    1.3457843    561.69

                     <1144>IL12RB1   U03187      IL12RB1   Human IL12 receptor component mRNA, complete cds                              0.4947442     260.28     526.09 0.33852032        87.67     258.98
                     <526>IL12RB2    U64198      IL12RB2   Human Il-12 receptor beta2 mRNA, complete cds                                 0.6112781     211.49     345.98    0.6208877     456.16     734.69
                     <271>IL13RA1    Y09328      IL13RA1   H.sapiens mRNA for IL13 receptor alpha-1 chain                                0.70456326   16337.04   23187.47   0.2841585    6729.68    23682.84 0.78412515    26963.57
                     <222>IL13RA2    U70981      IL13RA2   Human interleukin-13 receptor mRNA, complete cds                                2.25848    7041.67    3117.88    2.5512998    5860.08     2296.9    2.4573555    6897.6
                     <878>IL14       AF070546    IL14      Homo sapiens clone 24607 mRNA sequence                                        1.0592725    2097.01    1979.67 0.99661076      4404.91    4419.89    1.2250322   4757.89
                     <133>IL15       AF031167    IL15      Homo sapiens interleukin 15 precursor (IL-15) mRNA, complete cds.             0.8540849     987.51    1156.22     0.942833    1741.62    1847.22    1.1202717   1769.57
                                                           Human interleukin-15 receptor alpha chain precursor (IL15RA) mRNA, complete
                     <1167>IL15RA    U31628      IL15RA                                                                         0.61076427             556.73     911.53    0.96096295    1017.9    1059.25    0.7625271   4266.53
                                                                        cds
                     <487>IL16       M90391      IL16      Homo sapiens putative IL-16 protein precursor, mRNA, complete cds             1.2192823    9873.87     8098.1    1.5268314    11501.85   7533.15    1.1765691   14653.51
                     <1157>IL17C     NM_013278   IL17C     Homo sapiens interleukin 17C (IL17C), mRNA                                    0.74155056    103.78     139.95
Molecular Medicine




                     <828>IL17R      U58917      IL17R     Homo sapiens IL-17 receptor mRNA, complete cds                                 0.634181    18024.11   28421.08   0.5793386    8720.61    15052.7 0.74105406     25035.48

                     <96>IL18        D49950      IL18                                                                           0.92922115
                                                           Homo sapiens mRNA for interferon-gamma inducing factor(IGIF), complete cds                  321.78     346.29    0.9382102     426.06     454.12    1.2192446   1667.89

                     <206>IL18R1     U43672      IL18R1    Human putative transmembrane receptor IL-1Rrp mRNA, complete cds              0.57775813   2263.35    3917.47    0.3006253    1007.78    3352.28    0.5854506   3499.97
                     <312>IL1A       X02531      IL1A      Human mRNA for interleukin 1-alpha                                            0.7002356     190.24     271.68 0.23598208        50.04     212.05
                     <1184>IL1B      M15330      IL1B      Human interleukin 1-beta (IL1B) mRNA, complete cds                            0.45550618   6115.99    13426.8    0.5161091    7216.33    13982.18   0.6160257   12489.49
                     <260>IL1R1      M27492      IL1R1     Human interleukin 1 receptor mRNA, complete cds                               1.0934191    2634.67    2409.57 0.53614676      3949.45    7366.36 0.80100167     5746.13

                     <874>IL1R2      X59770      IL1R2     H.sapiens IL-1R2 mRNA for type II interleukin-1 receptor, (cell line CB23).    1.256898    8010.89    6373.54 0.48404616      5871.48      12130    1.0483619   14746.06

                     <116>IL1RL1     D12763      IL1RL1    Homo sapiens mRNA for ST2 protein                                             0.8475308     310.12     365.91    0.6731859    1416.41    2104.04 0.62203646     2221.23
                     <517>IL1RL2     U49065      IL1RL2    Human interleukin-1 receptor-related protein mRNA, complete cds               0.67877996    383.66     565.22 0.15078232        62.35     413.51    0.8730951    593.53
                     <599>IL1RN      X53296      IL1RN     H.sapiens mRNA for IRAP                                                       0.55658853   7683.95    13805.44   0.7941738    9531.46    12001.73 0.91627145    16670.66

                     <1255>IL2       V00564      IL2                                                                              2.2508907
                                                           Human mRNA encoding interleukin-2 (IL-2) a lymphozyte regulatory molecule                   120.04      53.33    0.44491383     78.99     177.54

                     <1201>IL2RA     X01057      IL2RA     Human mRNA for interleukin-2 receptor                                         0.8715331    2949.73    3384.53    1.2607999    9093.04    7212.12    0.9176935   22689.88
                     <261>IL2RB     M26062      IL2RB    Human interleukin 2 receptor beta chain (p70-75) mRNA, complete cds     0.83199114      7656.49     9202.61 0.57425386      12297.13    21414.1    0.923004    25636.13




                                                                                                                                                                                                                                   UNCORRECTED PROOF
                     <847>IL2RG     D11086      IL2RG    Human mRNA for interleukin 2 receptor gamma chain                        1.1098197      18515.1    16682.98    0.9683944    32975.99   34052.23   1.1232877    42881.89
                     <1254>IL3      M17115      IL3      Human multilineage-colony-stimulating factor mRNA                       0.92745274      10081.05   10869.61    1.0963682    13712.42   12507.13   1.0799869    1893.12
                     <765>IL3RA     M74782      IL3RA    Human interleukin 3 receptor (hIL-3Ra) mRNA, complete cds               0.96448857       723.27       749.9    0.71227986    211.54      296.99   1.5261478    1931.92
                     <766>IL4       M13982      IL4      Human interleukin 4 (IL-4) mRNA, complete cds                            2.0444221       143.13       70.01    0.3337114      173.6      520.21    1.452423       535
                     <875>IL4R      X52425      IL4R     Human IL-4-R mRNA for the interleukin 4 receptor                         1.1700894      8945.38     7645.04    1.6123149    34864.91   21624.13   0.8985294    33140.62
www.molmed.org



                     <314>IL5       X04688      IL5      Human mRNA for T-cell replacing factor (interleukin-5).                  0.8772769      6021.69     6864.07    1.3137997    5888.28     4481.87   1.2555861    6096.85
                     <553>IL5RA     M75914      IL5RA    Human interleukin 5 receptor alpha mRNA, complete cds                    2.5850065       294.82      114.05    0.7643095     289.23      378.42   0.6674723     345.21
                     <259>IL6       M14584      IL6      Human interleukin 6 mRNA, complete cds                                   2.2385752       313.02      139.83 0.99840224       406.17      406.82 0.99398464      391.62
                     <1203>IL6R     X12830      IL6R     Human mRNA for interleukin-6 (IL-6) receptor                            0.63998693      3707.15     5792.54 0.70659465      7767.92    10993.46 0.48011371     35213.94
                     <106>IL7       J04156      IL7      Human interleukin 7 (IL-7) mRNA, complete cds                            0.3724582       109.35      293.59    0.6842201     376.15      549.75    1.872899      289.7
                     <552>IL7R      M29696      IL7R     Human interleukin-7 receptor (IL-7) mRNA, complete cds                   1.3265984      8658.15     6526.58    1.0038888    21704.75   21620.67   1.0692009    12486.77
                     <234>IL8       M17017      IL8      Human beta-thromboglobulin-like protein mRNA, complete cds               1.5877538      5244.16     3302.88    0.4752578    3032.91     6381.61   1.0922685    13167.94

                     <985>IL8RA     L19591      IL8RA    Homo sapiens interleukin 8 receptor alpha (IL8RA) mRNA, complete cds 0.6689723          14406.78   21535.69 0.24477707      8405.31    34338.63   0.5843119    25731.5

                     <184>IL8RB     L19593      IL8RB    Homo sapiens interleukin 8 receptor beta (IL8RB) mRNA, complete cds 0.61527246          64923.16   105519.37    0.294904    18960.42   64293.53 0.47662464     30444.38
                     <1074>IL9R     M84747      IL9R     Human interleukin 9 receptor mRNA, complete cds.                         1.0548236        496.4       470.6    0.94715124     537.3      567.28 0.30493477      119.94
                     <1112>ILF1     X60787      ILF1     Human mRNA for transcription factor ILF                                 0.47447953        98.91      208.46    0.9492784     295.33      311.11
                     <502>ILF2      U10323      ILF2     Human nuclear factor NF45 mRNA, complete cds                             1.9382708      14320.08    7388.07 0.97234434      14024.92   14423.82   1.6334299    21028.71
                     <648>ILF3      U10324      ILF3     Human nuclear factor NF90 mRNA, complete cds                             0.9390626       6157.8     6557.39    1.3109776    10966.59     8365.2   0.8589002      11078
                     <113>ING1      AF001954    ING1     Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds          0.8645308       6193.3     7163.77 0.79879934      15904.87   19910.97   0.8424954    19460.8
                     <353>ING1L     NM_001564   ING1L    Homo sapiens inhibitor of growth family, member 1-like (ING1L) mRNA       1.083536      2446.05     2257.47    0.9242976    5401.05     5843.41 0.72325045     15366.96
                     <1433>INS      NM_000207   INS      Homo sapiens insulin (INS), mRNA                                        0.51991373       877.76     1688.28    0.9748331    3476.44     3566.19   0.7005335     932.27
                     <1305>INSIG1   NM_005542   INSIG1   Homo sapiens insulin induced gene 1 (INSIG1)                             1.0473691      3273.73     3125.67    0.5741361    4573.12     7965.22 0.82470506      6473.3
                     <441>INSR      NM_000208   INSR     Homo sapiens insulin receptor (INSR), mRNA.                              1.3022786      10547.61    8099.35    2.2119489    10989.14    4968.08   1.2710317    2351.18
                     <1391>INSRR    J05046      INSRR    Human insulin receptor-related receptor (IRR) mRNA, 3 ' end             0.29471287        58.25      197.65                                       1.0187755     174.72

                     <1352>IPF1     NM_000209   IPF1                                                                               1.0699444
                                                         Homo sapiens insulin promoter factor 1, homeodomain transcription factor (IPF1)         2383.13     2227.34 0.84815526      2617.11     3085.65   1.5742068    5284.03
                                                         Homo sapiens interleukin-1 receptor-associated kinase (IRAK) mRNA, complete
                     <1169>IRAK1    L76191      IRAK1                                                                          0.8312214          1682.6     2024.25    1.0745281    3803.69     3539.87 0.83346075     13717.03
                                                                     cds
Molecular Medicine




                     <820>IRAK2     AF026273    IRAK2    Homo sapiens interleukin-1 receptor-associated kinase-2 mRNA, complete 0.9530807
                                                                                                                                cds               204.96      215.05

                     <990>IRF1      X14454      IRF1     Human mRNA for interferon regulatory factor 1                            0.5914824      64923.16   109763.47   0.5057322    52766.74   104337.32 0.92912555    59347.86
                     <317>IRF2      X15949      IRF2     Human mRNA for interferon regulatory factor-2 (IRF-2).                   0.7312353      20518.55   28060.12 0.48546878      9346.76    19253.06   0.6760179    50630.72
                     <675>IRF3      Z56281      IRF3     H.sapiens mRNA for interferon regulatory factor 3                        0.9119537       904.12      991.41    1.0466368    2529.47     2416.76   1.1197988    3834.37
                                                         Human lymphocyte specific interferon regulatory factor/interferon regulatory factor 4
                     <212>IRF4      U52682      IRF4                                                                                 0.4306124    1706.9     3963.89 0.96962917       884.04      911.73   0.5287222    2115.46
                                                                      (LSIRF/IRF4) mRNA, complete cds
                     <686>IRF5      U51127      IRF5     Human interferon regulatory factor 5 (Humirf5) mRNA, complete cds        0.7151628       581.22      812.71    0.9533295    1187.82     1245.97   0.9618876     673.86

                     <130>IRF6      AF027292    IRF6     Homo sapiens interferon regulatory factor 6 (IRF6) mRNA, complete cds      2.33023         85.1       36.52    0.2789426       9.18       32.91   0.79313725    379.77

                     <1091>IRF7     U53830      IRF7     Homo sapiens interferon regulatory factor 7A mRNA, complete cds         0.32784122       728.65     2222.57    1.2237809    3200.64     2615.37   1.0106373    19609.62
                     <334>IRS1      S62539      IRS1     insulin receptor substrate-1 [human, skeletal muscle, mRNA, 5828 nt].    0.5421976       153.61      283.31 0.45601302       226.83      497.42
                     <1425>IRS2     NM_003749   IRS2     Homo sapiens insulin receptor substrate 2 (IRS2)

                     <1281>IRS4     NM_003604   IRS4     Homo sapiens insulin receptor substrate 4 (IRS4)                          1.057368        13902    13147.74 0.76258504      10476.5    13738.14   0.7190945    23336.76
                                                         Human interferon-induced 17-kDa/15-kDa protein mRNA (interferon-stimulated
                     <1075>ISG15    M13755      ISG15                                                                          0.11700238        2964.83    25339.91 0.97813904      12695.53   12979.27 0.92313606     25187.24
                                                                     protein, 15 kDa)
                     <795>ISG20       U88964      ISG20      Human HEM45 mRNA, complete cds                                            0.6315217       7970.41    12620.96    0.9172616   15596.97   17003.84   1.2273943    34282.82




                                                                                                                                                                                                                                        UNCORRECTED PROOF
                                                             Human IFN-responsive transcription factor subunit mRNA; Interferon-stimulated
                     <548>ISGF3G      M87503      ISGF3G                                                                                 0.48314372    48439.75   100259.51   0.7098425   31328.16   44133.96   1.1334207    60802.75
                                                                             transcription factor 3, gamma (48kD); p48
                                                             Human integrin alpha 4 subunit mRNA, complete cds; Integrin, alpha 4 (antigen
                     <193>ITGA4       L12002      ITGA4                                                                                   0.8450322     908.68     1075.32 0.85109705     1118.75    1314.48    0.8038249     967.54
                                                                          CD49D, alpha 4 subunit of VLA-4 receptor)
                                                             Human mRNA for leukocyte-associated molecule-1 alpha subunit (LFA-1 alpha
                     <1195>ITGAL      Y00796      ITGAL                                                                                   0.6632552      235.9      355.67 0.46425137      409.92     882.97    0.6796052    1335.56
                                                                           subunit)., CD11a
                                                             Integrin, alpha M (complement component receptor 3, alpha; also known as
                     <107>ITGAM       J03925      ITGAM                                                                                      0.73331   11814.71   16111.48 0.66214675     19159.99   28936.17    1.001348    25516.26
                                                                          CD11b (p170), macrophage antigen alpha polypeptide)
www.molmed.org



                                                             Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes
                     <307>ITGB1       X07979      ITGB1                                                                                   1.1285115    15915.15   14102.78 0.61357605     30695.46   50027.15 0.92156094     35709.04
                                                                          MDF2, MSK12);
                                                             Human leukocyte adhesion protein (LFA-1/Mac-1/p150,95 family) beta subunit
                     <772>ITGB2       M15395      ITGB2                                                                                   0.8100738    64923.16   80144.75    0.9581544   61603.13   64293.53   1.2412033    79281.81
                                                                           mRNA, CD18
                     <565>JAK1        M64174      JAK1       Human protein-tyrosine kinase (JAK1) mRNA, Janus kinase 1                 0.8591522        897.29     1044.39 0.40323994     4153.92    10301.36   0.5534425    15560.18

                     <128>JAK2        AF005216    JAK2                                                                              0.787402
                                                             Homo sapiens receptor-associated tyrosine kinase (JAK2) mRNA, Janus kinase 2               335.26      425.78    0.5362686    703.52    1311.88     0.983345    2295.54

                     <1221>JAK3       U09607      JAK3       Human JAK family protein tyrosine kinase (JAK3) mRNA, complete cds        1.5282527       2549.63     1668.33    1.7261021    813.65     471.38    0.9875109      740.1

                     <38>JUN          NM_002228   JUN                                                                            1.0768381
                                                             Homo sapiens v-jun avian sarcoma virus 17 oncogene homolog (JUN) mRNA.                    15625.18   14510.24    1.0736164   10224.95   9523.84 0.98631984      34731.26

                     <1237>KARP1      AF039597    KARP1      Ku86 autoantigen related protein 1                                       0.98176175       6372.89     6491.28 0.84518534     5489.42    6494.93    1.1541828    6273.78
                     <602>KATNA1      AF056022    KATNA1     Katanin p60 (ATPase-containing) subunit A 1                               1.6771866        571.82      340.94    0.6657887     419.6     630.23    0.6337155     243.22
                                                             H.sapiens mRNA for growth factor receptor tyrosine kinase; Kinase insert domain
                     <468>KDR         X61656      KDR                                                                                    1.5640031       60.48       38.67
                                                                            receptor (a type III receptor tyrosine kinase)
                                                             anti-oxidant protein 2 (non-selenium glutathione peroxidase, acidic calcium-
                     <1555>KIAA0106   NM_004905   KIAA0106                                                                               1.4319546     27784.56   19403.24    1.0679345   24712.08   23140.07   0.9967588    42829.21
                                                                          independent phospholipase A2)
                     <1621>KIAA0107   BC000904    KIAA0107   KIAA0107 gene product                                                     1.2234479       14327.04   11710.38    0.6683839   6323.38     9460.7    0.9046447    13164.2
                     <683>KIAA0194    D83778      KIAA0194   Human mRNA for KIAA0194 gene, partial cds.                                 2.167409        7144.3     3296.24    2.465388    8959.54    3634.13    1.7351516    12026.51
                     <1554>KIAA0436   AB007896    KIAA0436   putative L-type neutral amino acid transporter                             1.240379       1082.64      872.83    0.6714015    981.26    1461.51    0.7861708    1530.36
                     <1191>KIAA0566   AB011138    KIAA0566   ATPase type IV, phospholipid transporting (P-type) (putative)             1.1854763        304.62      256.96    1.1326563    1876.2    1656.46    1.4323949    2568.37
                     <152>KIAA0611    AB014511    KIAA0611   ATPase type IV, phospholipid-transporting (P-type),(putative)             0.7027959        3733.8     5312.78    0.526081    2826.26    5372.29    0.9392975    5287.39
                     <1338>KIAA0864   AB020671    KIAA0864   Homo sapiens mRNA for KIAA0864 protein, partial cds; IRS-1                1.1471845       8677.35     7564.04    1.3151258   14323.64   10891.46   1.1056925    16497.95
                                                             Human C-kit proto-oncogene; mast/stem cell growth factor receptor precursor
                     <321>KIT         X06182      KIT                                                                                0.97556406         297.03      304.47 0.11292071       74.95     663.74 0.73085165       1339.6
                                                                          (SCFR); CD117 antigen
                                                             Human stem cell factor mRNA; (SCF); mast cell growth factor (MGF); c-kit ligand
                     <313>KITLG       M59964      KITLG                                                                               1.2155832         224.19      184.43     0.74487     133.22     178.85 0.92582417       448.46
                                                                            (KITLG)
                     <1470>KLK1       BC005313    KLK1       kallikrein 1, renal/pancreas/salivary                                    0.53936446        124.07      230.03
Molecular Medicine




                     <1560>KLK11      AB041036    KLK11      kallikrein 11                                                              1.218261         1128       925.91    1.4702382    593.05     403.37    0.9855606     398.61
                     <1511>KLK12      NM_019598   KLK12      Homo sapiens kallikrein 12 (KLK12), mRNA                                  1.7514597       6742.84     3849.84    1.4982071   7900.72    5273.45    1.2047775    7275.88
                     <1675>KLK13      NM_015596   KLK13      kallikrein 13                                                              1.156047       1982.69     1715.06    1.320395    2901.04     2197.1    1.4487429    3272.29
                     <1516>KLK14      AF283670    KLK14      kallikrein 14                                                             1.4394737       7825.57     5436.41    3.6673982   2606.42      710.7    0.6881264      321.3
                     <1683>KLK2       AF188745    KLK2       kallikrein 2, prostatic                                                  0.67569506       3464.64     5127.52    1.1379175   8430.91    7409.07    1.6971841    23082.74
                     <1569>KLK3       BC005307    KLK3       kallikrein 3, (prostate specific antigen)                                  1.288487       3045.12     2363.33    1.0028071   1771.87    1766.91    1.0764093     2256.1
                     <1476>KLK4       NM_004917   KLK4       kallikrein 4 (prostase, enamel matrix, prostate)                         0.62039274        195.25      314.72    2.0597188    313.86     152.38    0.9946909     260.42
                     <1491>KLK5       BC008036    KLK5       kallikrein 5                                                             0.89683557        909.75      1014.4 0.87440944      855.12     977.94 0.27871698        213.5
                     <1565>KLK6       AF013988    KLK6       kallikrein 6 (neurosin, zyme)                                             1.2123955       5631.48     4644.92    1.3572205   8040.88    5924.52    1.4252644      6520
                     <1538>KLK7       NM_005046   KLK7       kallikrein 7 (chymotryptic, stratum corneum)                               1.454648        412.64      283.67    0.9306868    263.04     282.63    1.0781035      809.3
                     <1469>KLK8       AB008390    KLK8       kallikrein 8 (neuropsin/ovasin)                                                                                                                    0.10154717     17.59
                     <1589>KLKB1      NM_000892   KLKB1      kallikrein B, plasma (Fletcher factor) 1                                  1.1304193        379.12      335.38    0.8066052    184.64     228.91    0.9163654       773
                     <244>KRAS2       M54968      KRAS2      Human K-ras oncogene protein mRNA (KRAS2)                                 0.7869965       13626.19   17314.17 0.50514156     3336.94    6605.95    0.8348768    18485.75
                     <829>LAT         AF036905    LAT        Homo sapiens linker for activation of T cells (LAT) mRNA              1.1518728      18952.13   16453.32   1.3145074   19504.45   14837.84   1.1824092    45427.5




                                                                                                                                                                                                                                  UNCORRECTED PROOF
                     <1707>LAT1-3TM   NM_031211   LAT1-3TM   LAT1-3TM protein                                                     0.93432975      3078.28    3294.64 0.74083596     2667.18    3600.23    1.0397758    2879.68
                     <636>LBC         U03634      LBC        Human P47 LBC oncogene mRNA, complete cds                             1.2106414      2708.58    2237.31    0.7123658    266.09     373.53    0.7250747    1130.58
                     <773>LCK         M36881      LCK        Human lymphocyte-specific protein tyrosine kinase (lck) mRNA          1.1418554      3502.55    3067.42    1.1686752   15359.84   13142.95   1.0499151    19871.89
                     <1426>LHB        NM_000894   LHB        Homo sapiens luteinizing hormone beta polypeptide (LHB)               2.0554616       157.88      76.81                                      0.5601603      243.3
                     <1328>LHCGR      M73746      LHCGR      Homo sapiens lutropin/choriogonadotropin receptor (LHCGR) mRNA        0.7579875       411.61     543.03 0.41602892        89.7     215.61 0.86230403       765.45
www.molmed.org



                     <1474>LIECG3     BC009048    LIECG3     P3ECSL                                                                0.9978659      21579.41   21625.56   0.7319525   11124.36   15198.2    1.1679767    15752.83

                     <266>LIPA        M74775      LIPA                                                                               0.7562913
                                                             Human lysosomal acid lipase/cholesteryl esterase mRNA (cholesterol esterase)         29305.96   38749.57   0.975125    38577.04   39561.12   0.7559107    51068.35

                     <1077>LMNA       M13451      LMNA       Human lamin C mRNA, complete cds, Lamin A                             1.0202315       398.38     390.48    1.1365359   1311.21    1153.69    1.0362475    1556.62
                     <264>LMNB1       M34458      LMNB1      Human lamin B mRNA, complete cds,                                    0.36662066      4079.74    11127.96 0.77263224    6576.02    8511.19    0.8424425    8121.12
                     <771>LMNB2       M94362      LMNB2      Human lamin B2 (LAMB2) mRNA, partial cds                              0.8191165       922.62    1126.36 0.70293796       563.7     801.92 0.82169855       938.24
                     <1599>LOC51012   NM_016045   LOC51012   CGI-107 protein                                                       1.1216946      7168.29    6390.59    1.1032636   5876.92    5326.85      1.10183    8874.48
                     <1550>LOC51064   BC001231    LOC51064   glutathione S-transferase subunit 13 homolog                          1.1805537      3347.33    2835.39    1.6378958   11158.87   6812.93    1.2035974    39701.14
                     <664>LOC51082    NM_015972   LOC51082   RNA polymerase I 16 kDa subunit                                      0.78149503      2776.05    3552.23    3.5265243   6109.21    1732.36    1.5912881    13489.89
                     <1248>LOC51128   NM_016103   LOC51128   Homo sapiens GTP-binding protein Sara (LOC51128), mRNA                1.6129038      2584.63    1602.47 0.87041193      1354.3    1555.93    1.6983799    2823.03
                     <1372>LOC51141   AF125392    LOC51141   Homo sapiens insulin induced protein 2 mRNA, complete cds             1.1093676      1725.71    1555.58 0.76558346     2549.99    3330.78 0.70159423      2201.35
                     <1002>LOC51189   AB029042    LOC51189   ATPase inhibitor precursor                                            1.1068777      15883.44   14349.77   1.9431498   14311.9    7365.31    1.6359171    61799.89
                                                             G-protein coupled receptor SALPR; somatostatin and angiotensin-like peptide
                     <1473>LOC51289   NM_016568   LOC51289                                                                            1.4821272   17378.71   11725.52     1.8641    21416.57   11488.96   1.7993194    65172.57
                                                                         receptor

                     <1227>LOC51720   NM_016290   LOC51720   Homo sapiens retinoid x receptor interacting protein (LOC51720), mRNA 0.9693019      6654.82    6865.58    1.0402402   8858.57    8515.89    1.0537885    14189.2

                     <1162>LOC51728   NM_016310   LOC51728   RNA polymerase III subunit (hRPC11)                                   1.3292613        93.58       70.4    1.1422111    174.29     152.59 0.78008884       228.41
                     <1348>LOC55971   AF119666    LOC55971   Homo sapiens insulin receptor tyrosine kinase substrate mRNA         0.25708845       1303.5    5070.24    0.918066     718.91     783.07 0.44536057      1594.52
                                                             Human lyn mRNA encoding a tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral
                     <557>LYN         M16038      LYN                                                                                0.7658008     9030.2    11791.84   0.6993797   27396.76   39172.94 0.75423187     48176.53
                                                                        related oncogene homolog
                                                             Homo sapiens antagonizer of myc transcriptional activity (Mad) mRNA, complete
                     <62>MAD          L06895      MAD                                                                               0.43996754    1138.68     2588.1 0.18107599      786.27    4342.21    0.6786715    3169.07
                                                                         cds

                     <797>MADD        U77352      MADD       Homo sapiens MAP kinase-activating death domain protein (MADD) mRNA0.8368766         4186.45    5002.47    1.1355646   7843.56    6907.19    1.1069648    10931.4

                     <221>MADH2       U68018      MADH2                                                                   1
                                                             Human mad protein homolog (hMAD-2) mRNA; JV18-1.MADR2 OR SMAD2 .1143621              21139.35   18969.91   0.7067539   24470.35   34623.58 0.79280615     28072.68

                     <813>MADH3       U68019      MADH3      Homo sapiens mad protein homolog (hMAD-3) mRNA, complete cds          1.1134065      14389.12   12923.51   1.0161653   15441.21   15195.57   0.9032782    33065.76
Molecular Medicine




                                                             Human homozygous deletion target in pancreatic carcinoma (DPC4); mothers
                     <205>MADH4       U44378      MADH4                                                                           0.8089019       3231.83    3995.33 0.48113406     4617.15    9596.39    0.5455372    9510.89
                                                                       against dpp homolog 4 (SMAD4)
                     <121>MADH5       AF010601    MADH5      Homo sapiens SMAD5 (Smad5) mRNA, complete cds                         1.1097002       338.17     304.74    0.5914749    303.19      512.6    0.93247426   1839.38
                     <580>MADH6       AF035528    MADH6      Homo sapiens Smad6 mRNA, complete cds                                  1.460548      14752.5    10100.66   1.4788742   12052.47   8149.76 0.96182793      24307.18

                     <1236>MADH7      AF010193    MADH7      Homo sapiens MAD-related gene SMAD7 (SMAD7) mRNA, complete cds 1.1568631              646.27     558.64 0.40158725      709.44    1766.59 0.71318114      9534.27
                                                             Homo sapiens basic-leucine zipper transcription factor MafG (MAFG), mRNA,
                     <592>MAFG        AF059195    MAFG                                                                              1.3842522      5348.1    3863.53    3.293658    10260.47   3115.22    0.9281935    16910.61
                                                                         complete cds
                                                             Homo sapiens monoamine oxidase A (MAOA), nuclear gene encoding
                     <1292>MAOA       NM_000240   MAOA                                                                              0.9499168      136.94     144.16    1.3249636     81.79      61.73
                                                                     mitochondrial protein, mRNA
                     <1265>MAOB       M69177      MAOB       Human monoamine oxidase B (MAOB) mRNA, complete cds                   0.9484983        98.53     103.88
                     <1192>MAP2K1     L11284      MAP2K1     Homosapiens ERK activator kinase (MEK1) mRNA                         0.69349897      3671.89    5294.73    0.6220751    7725.8    12419.4 0.52321285      9865.99
                     <1103>MAP2K2     L11285      MAP2K2     Homosapiens ERK activator kinase (MEK2) mRNA                          0.8534769      12443.13   14579.34   1.3650774   22341.02   16366.12   1.1319177    32957.02
                     <1174>MAP2K3     D87116      MAP2K3     Human mRNA for MAP kinase kinase 3b ,complete cds, MEK3               0.8221027       3616.8    4399.45    1.8109413   11417.84   6304.92    0.6739333    21051.79
                     <667>MAP2K4      U17743      MAP2K4     Human JNK activating kinase (JNKK1) mRNA, complete cds; SEK1         0.99707025      1858.21    1863.67    0.5378442   1495.75    2781.01    0.7629556    1708.54
                     <516>MAP2K6      U39064      MAP2K6     Human MAP kinase kinase 6 mRNA, complete cds; MEK6                   0.99171907      2308.97    2328.25    0.9351561    1194.4    1277.22    0.8125838    3836.07
                                                             Homo sapiens mitogen-activated protein kinase kinase 7 (MKK7) mRNA,
                     <851>MAP2K7      AF013588    MAP2K7                                                                         1.4775182            150.5     101.86   1.3382832      292      218.19    0.6381593    367.35
                                                                       complete cds




                                                                                                                                                                                                                                  UNCORRECTED PROOF
                     <463>MAP3K1      AF042838    MAP3K1     Homo sapiens MEK kinase 1 (MEKK1) mRNA, partial cds                       0.6441791    2991.31     4643.6 0.55742025     3381.3    6065.98 0.35755402     11300.13
                     <756>MAP3K14     Y10256      MAP3K14    H.sapiens mRNA for serine/threonine protein kinase, NIK                   0.9366622     881.09     940.67   1.2464633   1015.02     814.32 0.96857053     4033.05
                                                             Homo sapiens mitogen-activated protein kinase kinase kinase 7 (MAP3K7),
                     <356>MAP3K7      NM_003188   MAP3K7                                                                            1.0595752       8404.19    7931.66 0.57346207     2653.3    4626.81 0.73414993     5177.71
                                                                        mRNA, TAK1
                     <181>MAP3K8      D14497      MAP3K8     Human mRNA for proto-oncogene protein, complete cds                       0.6203305    1925.45    3103.91 0.95752907    5612.48    5861.42    0.805606    5959.97
                                                                                                                                       1.0422331     6554.5     6288.9   0.7765911    3773.2    4858.67    1.0484596   3828.22
www.molmed.org



                     <629>MAP4K4      AF096300    MAP4K4     Homo sapiens HPK/GCK-like kinase HGK mRNA, complete cds

                     <740>MAPK1       M84489      MAPK1      Human extracellular signal-regulated kinase 2 mRNA; ERK2                   1.002783    21634.3    21574.26 0.68715566   16033.85   23333.65   0.843242    17944.67
                     <699>MAPK12      X79483      MAPK12     H.sapiens ERK6 mRNA for extracellular signal regulated kinase             0.8729575    1085.61     1243.6   1.5910201    1205.5     757.69    0.9008386   1059.17

                     <1334>MAPK13     AF004709    MAPK13                                                                            0.923262
                                                             Homo sapiens stress-activated protein kinase 4 (SAPK4) mRNA, complete cds              2762.16    2991.74   1.3868272   10045.94   7243.83    1.3862219   4610.56
                                                             Human p38 mitogen activated protein (MAP) kinase mRNA; cytokine suppressive
                     <500>MAPK14      L35253      MAPK14                                                                            0.7398923
                                                                        anti-inflammatory drug binding protein (CSAID binding protein; CSBP); MAX- 9472.19     12802.12 0.36498386   6346.62    17388.77 0.47144207    6672.56
                                                                                      interacting protein 2 (MXI2)
                     <1104>MAPK3      X60188      MAPK3      Human ERK1 mRNA for protein serine/threonine kinase                       0.42525408    462.77    1088.22 0.45622364     858.59    1881.95    0.594788    1155.34
                     <640>MAPK8       L26318      MAPK8      Human protein kinase (JNK1) mRNA; SAPK                                    0.9875918     1033.9    1046.89   1.0715348   1325.81     1237.3 0.93309635      443.51

                     <1377>MAPKAPK2   NM_004759   MAPKAPK2   Homo sapiens mitogen-activated protein kinase-activated protein kinase 2 0.8753265      418.94     478.61 0.44172588      728.3    1648.76    0.4492661   1005.79

                     <1353>MAPKAPK3   NM_004635   MAPKAPK3   Homo sapiens mitogen-activated protein kinase-activated protein kinase 3 1.143262      7859.24     6874.4   0.9424695   20578.2    21834.34 0.90915203    58072.05
                                                             Homo sapiens mRNA; cDNA DKFZp564J1022 (from clone DKFZp564J1022);
                     <1314>MAPKAPK5   AL110301    MAPKAPK5                                                                  1.069274                2019.88    1889.02    1.203275   3854.98    3203.74    0.856388    5334.03
                                                                      partial cds
                     <992>MAX         X60287      MAX        H.sapiens max mRNA                                                        1.4108802    10284.23   7289.23 0.77853024    7287.16    9360.15    1.1162932   8134.16
                     <1383>MC2R       NM_000529   MC2R       Homo sapiens melanocortin 2 receptor (adrenocorticotropic hormone)        1.3491844     331.67     245.83   1.7938199     402.3     224.27    1.4498044   1134.82
                     <511>MCM3        D38073      MCM3       minichromosome maintenance deficient (S. cerevisiae) 3                    1.1822721    2536.47    2145.42   1.3332088   15125.44   11345.14   0.8697322   35966.49

                     <1202>MDM2       M92424      MDM2       Human homolog of mouse-double-minute 2; p53-associated mdm2 protein            0.01       0.83     184.38

                     <120>MDM4        AF007111    MDM4       MDM2-like p53-binding protein (MDMX)                                      0.41200706    502.97    1220.78   0.8945902   2706.35    3025.24    0.8716918   8394.61
                     <372>MERTK       U08023      MERTK      Human cellular proto-oncogene (c-mer) tyrosine kinase mRNA                1.1917464     2285.4    1917.69 0.85377955    1884.65    2207.42 0.64081746     1345.14
                     <108>MET         J02958      MET        Human MET proto-oncogene mRNA, complete cds                               0.9295173     969.97    1043.52   1.1004822   4985.68    4530.45 0.50171906     3020.65
                     <1629>MGC12536   BC005397    MGC12536   hypothetical protein MGC12536                                             0.6364707    2512.92    3948.21 0.88018906    3399.07    3861.75    1.1574615   4012.78
                     <103>MGST1       J03746      MGST1      Human glutathione S-transferase mRNA, complete cds                        1.3087785    2595.36    1983.04   1.4138379   3267.86    2311.34    2.1226833   4610.15
                                                             Homo sapiens microsomal glutathione S-transferase 2 (MGST2) mRNA,complete
                     <528>MGST2       U77604      MGST2                                                                                 1.2413318   1288.85    1038.28   1.0422167   6022.23    5778.29    1.6233811   7966.11
                                                                         cds
Molecular Medicine




                                                             Homo sapiens microsomal glutathione S-transferase 3 (MGST3) mRNA, complete
                     <1095>MGST3      AF026977    MGST3                                                                                  1.344797     3122     2321.54   1.8521849   5474.54    2955.72    2.2981725   5017.37
                                                                         cds
                                                             Homo sapiens macrophage migration inhibitory factor (glycosylation-inhibiting
                     <1427>MIF        NM_002415   MIF                                                                                   0.7999722    863.21    1079.05   1.7651072   5125.73    2903.92    1.734338    23217.41
                                                                        factor) (MIF),
                     <305>MIG         X72755      MIG        H.sapiens Humig mRNA                                                      0.94084823    510.89     543.01   0.5269593     400.8     760.59    1.8165052    597.83
                     <638>MLH1        U07418      MLH1       Human mutL protein homolog; DNA mismatch repair protein MLH1              0.90942794    1717.1    1888.11   0.6033585   1242.11    2058.66    0.6406931    819.69
                     <70>MMP14        D26512      MMP14      Matrix metalloproteinase 14                                               1.0053082     1397.7    1390.32   0.9701189    886.97     914.29    0.5064787    453.03
                                                             Matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IV
                     <81>MMP2         J03210      MMP2                                                                                 1.3432257     349.87     260.47 0.91777945     157.39     171.49    1.1442255    479.03
                                                                         collagenase)
                     <1568>MOCS3      NM_014484   MOCS3      molybdopterin synthase sulfurylase                                        0.6606229     492.97     746.22   0.6159724    742.45    1205.33 0.90540624     1670.71

                     <368>MPL         NM_005373   MPL                                                                              0.6208277
                                                             Homo sapiens myeloproliferative leukemia virus oncogene (MPL), TPO receptor            3191.11    5140.09   0.7183637     3737      5202.1    0.7099008   4112.37

                     <1335>MRJ        AB014888    MRJ        Homo sapiens mRNA for MRJ                                                 0.84025496   7768.88    9245.86 0.46775976    8644.78    18481.24   0.6560323   13289.03
                     <345>MSH2        U04045      MSH2       Human DNA mismatch repair protein MSH2                                    1.8397506    4591.19    2495.55   0.8408147   13041.6    15510.67    1.15003    17790.93

                     <216>MSH3        U61981      MSH3       Human putative mismatch repair/binding protein hMSH3 (hMSH3) mRNA 0.9227033             556.63     603.26   1.1157078   1093.84      980.4    0.9988077    645.06
                                                          Human DNA mismatch repair protein MSH6; mutS alpha 160-kDa subunit; G/T
                     <386>MSH6      U54777      MSH6                                                                            1.0771365      6349.44     5894.74 0.52748835     1522.88    2887.04 0.73673326     3256.28
                                                                     mismatch binding protein (GTMBP; GTBP)




                                                                                                                                                                                                                               UNCORRECTED PROOF
                                                          H.sapiens RON mRNA for tyrosine kinase; Macrophage stimulating 1 receptor (c-
                     <910>MST1R     X70040      MST1R                                                                           1.0789845      3101.53     2874.49    1.3227339   5956.72    4503.34    1.3871993   5241.81
                                                                      met-related tyrosine kinase)
                     <1501>MTNR1B   NM_005959   MTNR1B    melatonin receptor 1B                                                 0.9665984      1397.74     1446.04    1.5712582   1950.12    1241.12    1.2715156   2528.04

                     <558>MX1       M30817      MX1                                                                             0.06494749
                                                          Human interferon-induced cellular resistance mediator protein (MxA)mRNA              9349.16    143949.53   0.6208143   10331.2    16641.37 0.50612485    11285.42

                     <273>MX2       M30818      MX2                                                                              0
                                                          Human interferon-induced cellular resistance mediator protein (MxB) mRNA.24179691    3741.95    15475.59 0.38000736     3134.16    8247.63    0.3742096   16519.02
www.molmed.org




                     <1233>MYB      M15024      MYB       Human c-myb mRNA, complete cds                                          1.03105       610.66      592.27    0.7461106    639.29     856.83 0.48355216      294.58
                     <839>MYBL2     X13293      MYBL2     Human mRNA for B-myb gene                                             0.4636864      2987.17     6442.22 0.92792445     7453.33    8032.26    1.3485004   9585.02
                     <890>MYC       V00568      MYC       Human mRNA encoding the c-myc oncogene                                0.8608059      1382.79     1606.39    0.8976625   3962.13    4413.83    0.814054    12690.85
                     <559>MYCL1     M19720      MYCL1     Human L-myc protein gene (MYCL1); gene only                           0.90978813     3365.37     3699.07    1.0927738   10194.29   9328.82    1.0450789   12182.85
                     <1082>MYCN     M13228      MYCN      Human N-myc oncogene protein                                          1.7270287       141.53       81.95
                                                          Human myleoid differentiation primary response protein MyD88 mRNA, complete
                     <529>MYD88     U70451      MYD88                                                                              0.5546103   7770.34    14010.45    0.7484724   27763.35   37093.35 0.93837714    54010.83
                                                                     cds
                                                          Homo sapiens myocilin, trabecular meshwork inducible glucocorticoid response
                     <1293>MYOC     NM_000261   MYOC                                                                               1.8278205    319.96      175.05
                                                                     (MYOC)
                                                          Homo sapiens N-acetyltransferase 1 (arylamine N-acetyltransferase) (NAT1),
                     <1215>NAT1     NM_000662   NAT1                                                                               1.0557636   1967.69     1863.76    1.0206076   2313.86    2267.14 0.84929645     7360.36
                                                                      mRNA

                     <360>NAT2      NM_000015   NAT2                                                                             0.73768187
                                                          Homo sapiens N-acetyltransferase 2 (arylamine N-acetyltransferase) (NAT2) RNA         167.38       226.9    1.9609641    126.09       64.3

                     <1676>NAT3     AF305814    NAT3      N amino acid transporter 3                                            0.8192138      2865.79     3498.22    1.4627441   6498.46    4442.65    1.6511084   10436.26
                     <148>NBS1      AF058696    NBS1      Nijmegen breakage syndrome 1 (nibrin)                                 0.4476603         649      1449.76 0.56593156      1709.3    3020.33 0.84585136     3788.23
                                                          Human silencing mediator of retinoid and thyroid hormone action (SMRT) mRNA,
                     <672>NCOR2     U37146      NCOR2                                                                             0.8166109    5081.01     6222.07    1.1937473   7817.91    6549.05    1.0968827   7595.54
                                                                      Nuclear receptor co-repressor 2
                     <560>NF1       M82814      NF1       Human type 1 neurofibromatosis protein mRNA (NF1); neurofibromin      0.5783922       682.74     1180.41 0.51306325      882.91    1720.86    0.2635104     155.4
                                                          Human moesin-ezrin-radixin-like protein mRNA, complete cds; neurofibromatosis
                     <836>NF2       L11353      NF2                                                                             0.77299505     3624.45     4688.84    0.6444307    1556.5    2415.31    0.7964636   2785.95
                                                                     2 (NF2)
                     <971>NFATC1    U08015      NFATC1    Human NF-ATc mRNA, complete cds                                       0.96952564     3687.94     3803.86    1.5293254   16437.8    10748.4    1.1412785   25610.12

                     <693>NFATC2    U43341      NFATC2    Human transcription factor NFAT1 isoform B (NFAT1) mRNA, complete cds 1.4504007      7173.87     4946.13    1.8563328   11205.92   6036.59    1.5918499   15504.22

                     <510>NFATC3    L41067      NFATC3    Homo sapiens NF-AT4c mRNA, complete cds                               0.90583545     6795.46     7501.87    0.6937594   4093.68    5900.72    1.2331263   10081.56
                     <1022>NFATC4   L41066      NFATC4    Homo sapiens NF-AT3 mRNA, complete cds                                                                                                        1.1676755    148.54
                     <209>NFIL3     U26173      NFIL3     Human bZIP protein NF-IL3A (IL3BP1) mRNA, complete cds                0.5979803      12529.2    20952.53 0.29815036     5951.14    19960.2    0.4766549   58359.16

                     <446>NFKB1     M58603      NFKB1     Human nuclear factor kappa-B DNA binding subunit (NF-kappa-B) mRNA,0.85647655
                                                                                                                             p105                4378      5111.64    0.833823    7496.82     8990.9 0.79081064     3950.02
Molecular Medicine




                     <1115>NFKB2    X61498      NFKB2     H.sapiens mRNA for NF-kB subunit (p49/p100)                           0.9640864      1423.57      1476.6    1.1181145   1208.76    1081.07    1.1208242   2119.77

                     <267>NFKBIA    M69043      NFKBIA                                                                            0.755938
                                                          Homo sapiens MAD-3 mRNA encoding IkB-like activity, complete cds, IkBalpha           53054.78   70184.04 0.85574096     55018.61   64293.53   0.7680473   49058.99

                     <1009>NFKBIB   L40407      NFKBIB    Homo sapiens thyroid receptor interactor (TRIP9) gene, complete cds   1.3436663      1428.68     1063.27    2.982753    2384.92     799.57    1.1250591   5000.19
                     <793>NFKBIE    U91616      NFKBIE    Human I kappa B epsilon (IkBe) mRNA, complete cds                     0.64413977     2856.38     4434.41    1.7586904   12605.22   7167.39    1.2197809   9153.31
                     <970>NFKBIL1   X77909      NFKBIL1   H.sapiens IKBL mRNA                                                    1.288644      6213.39     4821.65    2.3403683   8147.43    3481.26    1.1891019   8913.14
                     <961>NFRKB     U08191      NFRKB     Human R kappa B mRNA, complete cds                                    0.84483975     1526.22     1806.52 0.77024597     4346.19     5642.6 0.81227136     5990.29
                     <54>NGFB       X52599      NGFB      Human mRNA for beta nerve growth factor                               0.91451734      129.77       141.9    1.3424919     70.36      52.41    1.1855958    191.45
                     <461>NHP2L1    D50420      NHP2L1    Non-histone chromosome protein 2 (S. cerevisiae)-like 1               1.2230675      7361.68     6019.03    1.3927827   23621.58   16959.99   1.2928543   42036.11
                                                          Human putative NDP kinase (nm23-H2S) mRNA, complete cds; c-myc purine-
                     <1081>NME2     M36981      NME2                                                                          1.726791         1310.22      758.76    3.1296413   23153.24   7398.05    1.905943    69567.25
                                                                      binding transcription factor puf
                     <43>NME3       U29656      NME3      Non-metastatic cells 3, protein expressed in; Human DR-nm23 mRNA      1.2553838      2357.95     1878.27    1.4360954   2658.27    1851.04    2.0550933   3046.84
                                                          Human quinone oxidoreductase (NQO2) mRNA; NAD(P)H menadione
                     <790>NMOR2     J02888      NMOR2                                                                           0.79017556      316.41      400.43    0.761537     534.34     701.66    1.0575497   1221.29
                                                                  oxidoreductase 2, dioxin-inducible
                     <969>NNMT     U08021      NNMT     Human nicotinamide N-methyltransferase (NNMT) mRNA, complete cds      1.738842        57.66      33.16     1.810992     456.37       252     1.0485297     714.94




                                                                                                                                                                                                                             UNCORRECTED PROOF
                     <1319>NOS1    U17327      NOS1     Human neuronal nitric oxide synthase (NOS1) mRNA                    0.32661304        1656     5070.22    2.4707925    3663.79    1482.84 0.65140885      5024.61
                     <1349>NOS2A   U20141      NOS2A    Human inducible nitric oxide synthase mRNA                           1.1896523       214.53     180.33    1.2562027     510.86     406.67    0.8524222    1279.75
                     <1378>NOS3    M93718      NOS3     Human nitric oxide synthase mRNA (endothelial)                       1.0247936       621.65     606.61    1.2836815     774.92     603.67    1.4953895    1574.72
                     <23>NOTCH4    NM_004557   NOTCH4   Homo sapiens Notch (Drosophila) homolog 4                            1.2162108      2217.59    1823.36    1.3022972    1947.82    1495.68    0.7263541     455.01
                     <349>NOVA1    U04840      NOVA1    Human onconeural ventral antigen-1 (Nova-1) mRNA, complete cds       1.4136745        513.8     363.45    0.7843883      123.8     157.83    1.2092484      438.8
www.molmed.org




                     <1670>NOX1    NM_007052   NOX1     NADPH oxidase 1                                                     0.97935253      10431.74   10651.67   1.1767557    16826.57   14299.12   1.5070192    27281.69
                     <1653>NOX4    AB041035    NOX4     NADPH oxidase 4                                                       0.976946      5513.17    5643.27    1.6467848    7425.83    4509.29    1.6795707    20918.18
                     <1542>NOX5    AF317889    NOX5     NADPH oxidase, EF hand calcium-binding domain 5                      1.1000925      2627.12    2388.09    1.3826332    2437.61    1763.02    1.1983054    2753.55
                                                        Homo sapiens candidate tumor suppressor gene 21 protein mRNA, complete
                     <838>NPR2L    AF040708    NPR2L                                                                       0.78856325       2373.11    3009.41    1.0693332    4954.83    4633.57     1.100345    5205.05
                                                                  cds
                     <1160>NR1D1   X72631      NR1D1    Homo sapiens mRNA for Rev-ErbAalpha protein (hRev gene).             1.4878954      18591.12   12494.91   1.6214653    3539.74    2183.05    0.8832365    1365.36
                     <111>NR1D2    D16815      NR1D2    Homo sapiens mRNA for EAR-1r, complete cds                           1.4821892      1563.25    1054.69    0.8592008    4135.05    4812.67    0.6795013     2994.8
                     <1154>NR1H2   U07132      NR1H2    Human steroid hormone receptor Ner-I mRNA, complete cds              0.8266968       975.99    1180.59    0.7425739    1890.66    2546.09    0.7486882    2592.61
                     <1012>NR1H3   U22662      NR1H3    Human nuclear orphan receptor LXR-alpha mRNA, complete cds           1.2367445       396.76     320.81                                       0.7758484     568.79
                     <220>NR1H4    U68233      NR1H4    Human farnesol receptor HRR-1 (HRR-1) mRNA, complete cds             1.1810542      5597.76    4739.63    1.0437788    4874.76     4670.3 0.93066424       4186.1
                     <892>NR1I2    AF061056    NR1I2    Homo sapiens orphan nuclear receptor PXR mRNA, complete cds         0.87392837       374.12     428.09    3.2695303      146.9      44.93    1.6466382     469.72
                     <955>NR1I3    Z30425      NR1I3    H.sapiens mRNA for orphan nuclear hormone receptor (CAR)             0.7997621       390.06     487.72    0.9567437     717.73     750.18    0.9595464     760.69
                     <319>NR2C1    M29960      NR2C1    Human steroid receptor (TR2-11) mRNA, complete cds.                  1.2387669      1506.96     1216.5    1.1033777    1185.16    1074.12    1.1809431    5344.96
                     <499>NR2C2    L27586      NR2C2    Human TR4 orphan receptor mRNA, complete cds                          1.331865        1814       1362     0.8815099    5620.71    6376.23    1.2150369     9876.5
                     <458>NR2E1    Y13276      NR2E1    Homo sapiens mRNA for tailless gene homologue                        0.8183037       390.56     477.28 0.30344805       103.67     341.64    1.1702807     586.65

                     <398>NR2E3    NM_014249   NR2E3                                                                          0.8245014
                                                        Homo sapiens nuclear receptor subfamily 2, group E, member 3 (NR2E3), mRNA           517.96     628.21                                       0.20794272     44.14
                                                        Human mRNA for chicken ovalbumin upstream promoter transcription factor
                     <1102>NR2F1   X16155      NR2F1                                                                          0.7502853      282.73     376.83    1.0972527      460.1     419.32
                                                                 (COUP-TF).

                     <715>NR2F2    M64497      NR2F2    Human apolipoprotein AI regulatory protein (ARP-1) mRNA, complete cds 1.6116054     1179.55     731.91    2.6438708     918.56     347.43    2.4949038     308.42

                     <1138>NR2F6   NM_005234   NR2F6    Homo sapiens nuclear receptor subfamily 2, group F, member 6 (NR2F6), 0.77523714
                                                                                                                              mRNA           589.25     760.09 0.38828474       206.02     530.59    1.5852894    1293.39

                     <254>NR3C1    M10901      NR3C1    Human glucocorticoid receptor alpha mRNA, complete cds              0.79294014      10119.51   12762.01   0.5101073    9422.16    18470.94   0.7483851    10487.09
                     <268>NR3C2    M16801      NR3C2    Human mineralocorticoid receptor mRNA (hMR), complete cds            1.0067235      1676.98    1665.78 0.84048164      1348.62    1604.58    0.9065741    1269.53
Molecular Medicine




                     <1190>NR4A1   L13740      NR4A1    Human TR3 orphan receptor mRNA, complete cds.                       0.82397234      6665.31    8089.24    0.7502293     482.51     643.15 0.55052996       708.51
                     <343>NR4A2    X75918      NR4A2    H.sapiens mRNA for NOT                                               1.0891653      1095.94    1006.22    0.6279965    2155.19    3431.85 0.70608205      2271.36

                     <335>NR5A2    U80251      NR5A2    Homo sapiens hepatocytic transcription factor (hB1F) mRNA, complete cds 1.4803504    309.26     208.91    0.7270262     227.85      313.4    1.2959666     208.21

                     <700>NR6A1    U64876      NR6A1    Human nuclear orphan receptor mRNA, complete cds                    0.86364317      7239.55    8382.57 0.88656116      4798.45    5412.43    1.1961832      9881
                     <325>NRAS     X02751      NRAS     Human N-ras mRNA and flanking regions; transforming p21 protein     0.81216455       1198.3    1475.44    0.6866396    1512.88    2203.31    1.0204692     973.65
                     <1327>NRF     NM_017544   NRF      Homo sapiens transcription factor NRF                                1.1878597      2957.64    2489.89    1.0608048     2013.1    1897.71    0.8989071    2983.23
                     <1302>NRF1    NM_005011   NRF1     Homo sapiens nuclear respiratory factor 1 (NRF1)                     1.0814296      1206.14    1115.32    0.76591456   2597.04    3390.77    0.7974468    2094.47
                                                        Human recombinant glial growth factor 2 mRNA, complete cds and flanking
                     <585>NRG1     L12260      NRG1                                                                             3.31055     3347.86    1011.27    1.6070598    11513.25   7164.17    2.0019546    7999.57
                                                                  regions (neuregulin 1)
                     <842>NTE      AJ004832    NTE      Homo sapiens mRNA for neuropathy target esterase                    0.86781615      3204.42    3692.51    1.6945487    5757.67    3397.76    1.1998482    4377.85

                     <788>NTF5     M86528      NTF5                                                                             0.1572184
                                                        Human neurotrophin-4 (NT-4) gene; neurotrophin 5 (neurotrophin 4/5) (NTF5)          5882.45    37415.79 0.19663015     2834.73    14416.56 0.65668666     24250.84

                     <34>NTHL1     U79718      NTHL1    Human endonuclease III homolog 1 (OCTS3) mRNA                        1.3353668       562.55     421.27    1.8540623    1184.82     639.04    1.3787427    6027.16
                                                        Human mRNA of transforming tyrosine kinase protein trk oncogene; high-affinity
                     <918>NTRK1    X03541      NTRK1                                                                           0.77149093   28764.6    37284.43   0.6406198    30188.21   47123.44    0.955695    34362.29
                                                                  nerve growth factor receptor precursor;
                     <1464>OGFR     NM_007346   OGFR      opioid growth factor receptor                                          0.71642303      4334.18    6049.75    1.0064324   4359.04    4331.18    0.9224455    20251.12




                                                                                                                                                                                                                                 UNCORRECTED PROOF
                     <1452>OPRD1    U07882      OPRD1     opioid receptor, delta 1                                                1.0722736      1066.88     994.97    1.6298391   1924.84      1181     1.2799028    1459.87
                     <1532>OPRK1    L37362      OPRK1     opioid receptor, kappa 1                                                2.7517056       693.76     252.12    21.685032    417.22      19.24    1.5857866     1084.9
                     <1453>OPRL1    U30185      OPRL1     opiate receptor-like 1                                                  1.0126804      1301.75    1285.45    1.1155945   1390.12    1246.08    1.0581625    1718.17
                     <1594>OPRM1    NM_000914   OPRM1     opioid receptor, mu 1                                                  0.91757876      14473.63   15773.72   1.042561    20949.9    20094.65    1.311829    32408.84
                     <1515>ORP150   U65785      ORP150    Oxygen regulated protein (150kD)                                         0.863668      1279.93    1481.97    1.1225941   1553.76    1384.08           1     4696.84
www.molmed.org



                                                          Human oncostatin-M specific receptor beta subunit (OSMRB) mRNA, complete
                     <233>OSMR      U60805      OSMR                                                                          1.0965002           547.34     499.17    1.0291083    394.91     383.74    1.4301119     456.22
                                                                     cds
                     <1411>OXT      M25650      OXT       Human oxytocin mRNA                                                     0.7919333       228.94     289.09    1.197192     498.81     416.65
                     <1270>OXTR     X64878      OXTR      H.sapiens mRNA for oxytocin receptor                                   0.76059306      2572.82    3382.65 0.26471555      282.11    1065.71    0.6490974     259.97
                     <119>P2Y5      AF000546    P2Y5      Homo sapiens purinergic receptor P2Y5 mRNA                              1.2592908      4800.24    3811.86    1.3568339   13933.6    10269.2     1.507537    39956.42
                     <179>P66       D26018      P66       DNA polymerase delta, subunit 3                                        0.74965215       587.15     783.23    0.5874321     606.6    1032.63    0.7496761     839.12
                     <509>PAK1      U24152      PAK1      Human p21-activated protein kinase (PAK-alpha; PAK1)                   0.68051434      14061.48   20663.02   0.6808104   39618.83   58193.63 0.64364624     41112.88

                     <665>PAK2      U24153      PAK2      Human p21-activated protein kinase (PAK-gamma; PAK2); PAK65; S6/H4 0.66526544
                                                                                                                             kinase              6588.13    9903.01    0.5901849   12334.93   20900.11    0.669564    16095.22

                     <378>PAP       X76770      PAP       poly(A) polymerase                                                      1.1389066      3424.02    3006.41 0.95210105     4764.19    5003.87    0.8613459    10521.46
                     <1222>PC4      U12979      PC4       activated RNA polymerase II transcription cofactor 4                    3.2224772       617.62     191.66    3.0806284   2266.11      735.6    2.3895876     6578.2
                     <354>PCNA      NM_002592   PCNA      Homo sapiens proliferating cell nuclear antigen (PCNA) mRNA             0.8715079      10118.25   11610.05 0.81946003    6012.28    7336.88    0.9655665    10896.09
                                                          Procollagen (type III) N-endopeptidase; Human metallopeptidase PRSM1
                     <21>PCOLN3     U58048      PCOLN3                                                                             0.741231       1607.1    2168.15 0.61434823      878.69    1430.28    0.7654703    1538.45
                                                                     mRNA
                     <677>PDAP1     U41745      PDAP1     Human PDGF associated protein mRNA (PAP)                                0.5603602       1667.8     2976.3    0.8372195   3099.42    3702.04    1.1439923    3711.42
                                                          Homo sapiens apoptosis-inducing factor AIF mRNA, nuclear gene encoding
                     <489>PDCD8     AF100928    PDCD8                                                                            1.048409         2940.2    2804.44 0.82957834     4724.88    5695.52 0.97917026      5515.48
                                                                    mitochondrial protein; Programmed cell death 8

                     <326>PDGFA     X06374      PDGFA     Human platelet-derived growth factor A subunit precursor (PDGFA; PDGF-1)0.763497       4635.32    6071.17    1.0289999   4687.99    4555.87    0.8502552    5249.51
                                                          Human platelet-derived growth factor B subunit precursor (PDGFB; PDGF2);
                     <898>PDGFB     X02811      PDGFB                                                                          0.55244213         155.75     281.93                                      0.8754204     330.55
                                                                      bacaplermin; c-sis
                                                          Human platelet-derived growth factor receptor alpha (PDGFRA) mRNA; CD140A
                     <275>PDGFRA    M21574      PDGFRA                                                                          0.7938201         201.67     254.05                                       1.111113     677.29
                                                                     antigen
                                                          Human platelet-derived growth factor receptor mRNA (PDGFRB); CD140B
                     <784>PDGFRB    M21616      PDGFRB                                                                         0.75797176        1306.91    1724.22    0.5017778    292.12     582.17 0.72130144      1058.38
                                                                    antigen
                                                          Human mRNA for PDGF receptor beta-like tumor suppressor (PRLTS),complete
                     <668>PDGFRL    D37965      PDGFRL                                                                          1.5389097          36.98      24.03
                                                                       cds

                     <447>PECAM1    M28526      PECAM1                                                                               0.7898836
                                                          Platelet/endothelial cell adhesion molecule (CD31 antigen), neutrophil; CD31           23000.33   29118.63   0.5281672   22922.53   43400.14 0.79892325     53716.81
Molecular Medicine




                     <1614>PECI     AF069301    PECI      peroxisomal D3,D2-enoyl-CoA isomerase                                   1.3648212      9481.44    6947.02    1.0950699   9957.92    9093.41    1.0736144    22895.17
                                                          Homo sapiens mRNA for phosphatidylethanolamine N-
                     <1146>PEMT     AB029821    PEMT                                                                              1.0425485       340.34     326.45    1.187031     314.86     265.25    0.6825103      44.37
                                                                methyltransferase,complete cds
                     <1386>PENK     NM_006211   PENK      Homo sapiens proenkephalin (PENK), mRNA                                0.61895853         39.7      64.14                                      0.85815907    513.96
                     <135>PEX1      AF030356    PEX1      Peroxisome biogenesis factor 1                                          1.1039801      1142.52    1034.91    1.1445467    720.95      629.9    0.9966755    1136.23
                     <1668>PGDS     NM_014485   PGDS      prostaglandin D2 synthase, hematopoietic                               0.74362266      1593.39    2142.74    1.5803728   3702.15    2342.58    1.8725512    6703.49
                     <901>PGF       X54936      PGF       H.sapiens mRNA for placenta growth factor (PlGF).                       1.8880627        187.9      99.52                                      0.53319675    114.52
                     <611>PGK1      V00572      PGK1      phosphoglycerate kinase 1                                               1.3815368      89308.63   64644.41   1.1511635   74012.37   64293.53   1.0007014    63919.76
                     <827>PIG3      AF010309    PIG3      Homo sapiens Pig3 (PIG3) mRNA; Quinone oxidoreductase homolog            1.238413      1757.37    1419.05    1.2558321    3033.5    2415.53    1.1537966    4871.56
                     <86>PIG6       AF010310    PIG6      p53 induced protein (Proline oxidase homolog)                           0.7079744       206.24     291.31    15.337502     12.27        0.8
                                                          H.sapiens mRNA for phosphoinositide 3-kinase; Phosphoinositide-3-kinase, class
                     <286>PIK3C2A   Y13367      PIK3C2A                                                                          0.7108846       1329.02    1869.53 0.41217685      908.85      2205     0.3817721     402.09
                                                                       2, alpha polypeptide
                                                          H.sapiens mRNA for phosphoinositide 3-kinase, Phosphoinositide-3-kinase, class
                     <581>PIK3C2B   Y11312      PIK3C2B                                                                          1.0991868       1892.36     1721.6    2.4623096   15462.32    6279.6    1.5237697    13136.86
                                                                       2, beta polypeptide
                                                          Homo sapiens mRNA for C2 domain containing PI3-kinase, phosphoinositide-3-
                     <151>PIK3C2G   AJ000008    PIK3C2G                                                                         0.63717276          49.4      77.53
                                                                     kinase, class 2, gamma polypeptide
                                                          H.sapiens mRNA for phosphatidylinositol 3-kinase, Phosphoinositide-3-kinase,
                     <411>PIK3C3    Z46973      PIK3C3                                                                               1.8753364    7748.59    4131.84 0.98966783       6783.55    6854.37 0.97688454     7198.74
                                                                       class 3




                                                                                                                                                                                                                                   UNCORRECTED PROOF
                                                          Human phosphoinositide 3'-hydroxykinase p110-alpha subunit mRNA,
                     <226>PIK3CA    U79143      PIK3CA                                                                              0.94543815    3362.29    3556.33 0.39788884       4090.21    10279.78    0.58446    2497.69
                                                                   Phosphoinositide-3-kinase, catalytic, alpha polypeptide
                                                          phosphatidylinositol 3-kinase p110 beta isoform=110 kda catalytic subunit
                     <359>PIK3CB    S67334      PIK3CB                                                                               0.8222715
                                                                     [human, mRNA Partial, 3213 nt]. Phosphoinositide-3-kinase, catalytic, beta    422.59     513.93 0.35049498        332.08     947.46    0.6056605    297.24
                                                                                    polypeptide
                                                          Human phosphatidylinositol 3-kinase catalytic subunit p110delta
                     <808>PIK3CD    U86453      PIK3CD                                                                              0.80764246    6591.55    8161.47    1.2300353      22082     17952.33 0.81910586    57278.21
                                                                   mRNAPhosphoinositide-3-kinase, catalytic, delta polypeptide
www.molmed.org



                                                          H.sapiens mRNA for phosphatidylinositol 3 kinase gamma, Phosphoinositide-3-
                     <217>PIK3CG    X83368      PIK3CG                                                                               1.1275266    6825.02    6053.09 0.61856586       2984.63    4825.08    0.5397255   4482.62
                                                                      kinase, catalytic, gamma polypeptide
                                                          Human P13-kinase associated p85, Phosphoinositide-3-kinase, regulatory
                     <274>PIK3R1    M61906      PIK3R1                                                                               1.2296591     5631.9    4580.05 0.62194806       3245.02    5217.51    0.8411102    8337.9
                                                                      subunit, polypeptide 1 (p85 alpha)
                                                          H.sapiens mRNA for p85 beta subunit of phosphatidyl-inositol-3-kinase,
                     <799>PIK3R2    X80907      PIK3R2                                                                              1.2334176     1282.52    1039.81    0.8708421     1497.77    1719.91 0.76742715     1347.84
                                                                     Phosphoinositide-3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
                                                          Homo sapiens mRNA for p55pik, Phosphoinositide-3-kinase, regulatory subunit,
                     <97>PIK3R3     D88532      PIK3R3                                                                           0.92805153        243.53     262.41 0.60792106        390.03     641.58    0.7773178    435.57
                                                                     polypeptide 3 (p55, gamma)
                                                          H.sapiens mRNA for adaptor protein p150, Phosphoinositide-3-kinase, regulatory
                     <245>PIK3R4    Y08991      PIK3R4                                                                           0.74719226       2329.23    3117.31 0.75098825       2635.06    3508.79    1.0113075   3037.28
                                                                     subunit 4
                     <563>PIM1      M54915      PIM1      Human h-pim-1 protein (h-pim-1) mRNA, complete cds                        1.205688      64775.48   53724.91   2.2742994    146222.73   64293.53   0.9836097   62828.03
                     <424>PIM2      U77735      PIM2      Human pim-2 protooncogene homolog pim-2h mRNA, complete cds.            1.0340712       29888.93   28904.13   1.3034031    52173.53    40028.7    0.8724257   49607.73
                     <1150>PIPPIN   AB027011    PIPPIN    ortholog of rat pippin                                                                                        0.05257433       1.45      27.58
                                                          Human calcium-dependent phospholipid-binding protein (PLA2) mRNA;
                     <277>PLA2G4A   M72393      PLA2G4A                                                                            1.335251        937.68     702.25 0.86942065         810.7     932.46    1.0091349    848.41
                                                                  Phospholipase A2, group IVA (cytosolic)
                                                          Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent)
                     <1404>PLA2G6   NM_003560   PLA2G6                                                                           1.0906402          995.7     912.95    1.2557738     1479.54    1178.19    1.4989628    2955.4
                                                                     (PLA2G6)
                                                          Homo sapiens macrophage inhibitory cytokine-1 (MIC-1) mRNA (prostate
                     <823>PLAB      AF019770    PLAB                                                                             1.3679467        4407.21    3221.77    1.7952471     6816.93    3797.21    1.2683465    9686.4
                                                                     differentiation factor)
                     <1259>PLAT     NM_000931   PLAT      Homo sapiens plasminogen activator, tissue (PLAT); t-PA                0.50980246        138.08     270.85    1.9503475      238.43     122.25    0.653775     660.45

                     <786>PLCB2     M95678      PLCB2     Homo sapiens phospholipase C-beta-2 mRNA; Phospholipase C, beta 2 0.74606067            1058.69    1419.04     0.431274      505.41     1171.9    0.9083325   1686.51
                                                          H.sapiens mRNA encoding phospholipase c; Phospholipase C, beta 3
                     <923>PLCB3     Z16411      PLCB3                                                                        1.1016138            1665.64      1512     1.2283268     2469.76    2010.67    1.1247814   2906.12
                                                                   (phosphatidylinositol-specific)
                                                          Homo sapiens phospholipase C beta 4 (PLCB4) mRNA; Phospholipase C, beta
                     <397>PLCB4     L41349      PLCB4                                                                        0.6648824            8293.73    12473.98   0.6679098     3383.15    5065.28    0.7120784   12056.3
                                                                     4
                     <785>PLCG1     M34667      PLCG1     Human phospholipase C-gamma mRNA, complete cds                         0.12054948         44.93     372.71                                        3.0739567   2227.85
                     <902>PLG       X05199      PLG       Human mRNA for plasminogen                                             0.73620874        592.81     805.22    1.5268375     4052.41    2654.12    0.7432664   2879.02
                     <1505>PLTP     BC005045    PLTP      phospholipid transfer protein                                          0.84179604       1248.19    1482.77    1.3835744     1481.49    1070.77 0.91663694     1029.86
Molecular Medicine




                     <751>PMM1      U86070      PMM1      phosphomannomutase 1                                                    1.3706878       1301.66     949.64    1.1907123     1457.67     1224.2    1.2165701   4553.61
                     <374>PMS1      U13695      PMS1      Human DNA mismatch repair protein PMS1 (PMS1 protein homolog 1)        0.88260466        8960.6    10152.45 0.65610975      9118.41    13897.69 0.81170875    15484.44
                     <379>PMS2      U14658      PMS2      Human DNA mismatch repair protein PMS2 (PMS1 protein homolog 2)        0.91643786        547.26     597.16    0.7436016     1055.84     1419.9    1.0482563   3616.83
                     <1084>PNMT     J03727      PNMT      Human phenylethanolamine N-methyltransferase mRNA, complete cds         0.7786467        724.85     930.91    0.6851556       38.54      56.25
                     <328>POLA      X06745      POLA      polymerase (DNA directed), alpha                                       0.69527143        913.83    1314.35    1.4391484     1676.91    1165.21    1.0268664   1081.28
                     <940>POLA2     L24559      POLA2     polymerase (DNA-directed), alpha (70kD)                                0.81291634         943.3    1160.39    0.8225058      982.22    1194.18    0.9904377    4998.6
                     <646>POLB      D29013      POLB      polymerase (DNA directed), beta                                         1.0311639       2377.73    2305.87 0.67071235       3441.15    5130.59 0.75537986     6007.06
                     <1066>POLD1    M81735      POLD1     polymerase (DNA directed), delta 1, catalytic subunit (125kD)             0.668154       732.23     1095.9
                     <670>POLD2     U21090      POLD2     polymerase (DNA directed), delta 2, regulatory subunit (50kD)           1.1114161       1137.99    1023.91    1.2955692      1161.4     896.44    1.1548302    468.48
                     <863>POLE      L09561      POLE      polymerase (DNA directed), epsilon                                      1.5210778       3925.43    2580.69    1.3926585     3998.42    2871.07    1.2747993   6044.27
                     <131>POLE2     AF025840    POLE2     polymerase (DNA directed), epsilon 2                                   0.30021903        374.16    1246.29    1.0721495      1513.8    1411.93    0.8614467   1444.31
                     <705>POLG      D84103      POLG      polymerase (DNA directed), gamma                                          1.188858       806.45     678.34    1.0515904     1609.68    1530.71    1.1060168   5213.21
                     <285>POLG2     U94703      POLG2     polymerase (DNA directed), gamma 2, accessory subunit                   1.2694306       4633.46    3650.03    1.3282374     9765.44    7352.18    1.3720872   7766.37
                     <191>POLI       AF245438    POLI      polymerase (DNA-directed), iota                                         0.9320171         1408.11    1510.82    0.7138529   3719.83    5210.92    1.0904882    3271.77




                                                                                                                                                                                                                                     UNCORRECTED PROOF
                     <188>POLK       AB027564    POLK      polymerase (DNA-Directed) kappa                                        0.48805833         1610.49    3299.79    0.575932     1395.8    2423.55 0.76434726      1960.65
                     <1003>POLL      AJ131890    POLL      polymerase (DNA-directed), lambda                                       1.7356337         1126.27     648.91    2.8095567    2941.1    1046.82     1.163942    3979.18
                     <1004>POLM      AJ131891    POLM      polymerase (DNA-directed), mu                                            0.876284         1037.38    1183.84    1.1021267    677.83     615.02    1.3634148    4113.15
                     <628>POLQ       AF043628    POLQ      polymerase (DNA-directed), theta                                       0.88188195         25952.87   29428.96   1.0547681   26086.6    24732.07 0.95208997     60814.71
                                                           polymerase (RNA) II (DNA directed) polypeptide A (220kD); H.sapiens mRNA for
                     <911>POLR2A     X63564      POLR2A                                                                          0.93427324          1736.16     1858.3    1.3068321   6192.96    4738.91    1.0040889    8169.99
                                                                        RNA polymerase II largest subunit
www.molmed.org




                     <1243>POLR2B    X63563      POLR2B    polymerase (RNA) II (DNA directed) polypeptide B (140kD)                1.2361618         11146.36   9016.91 0.80808437     31212.34   38625.1 0.83805525      21684.05
                     <806>POLR2C     AF008443    POLR2C    polymerase (RNA) II (DNA directed) polypeptide C (33kD)                0.84355444         2283.89    2707.46 0.95727307     2855.22    2982.66 0.95379704      4337.22
                     <571>POLR2D     U85510      POLR2D    polymerase (RNA) II (DNA directed) polypeptide D                        1.0953685          683.74     624.21    0.8217733   2173.27    2644.61    0.8363226    2716.61
                     <1155>POLR2E    J04965      POLR2E    polymerase (RNA) II (DNA directed) polypeptide E (25kD)                 0.9929083          905.87     912.34    1.0043772   3281.22    3266.92    1.3289096    6288.52
                     <1125>POLR2F    Z27113      POLR2F    polymerase (RNA) II (DNA directed) polypeptide F                         1.306264         4281.62    3277.76    1.819952    23958.85   13164.55   1.3257208    22812.01
                     <1028>POLR2G    U20659      POLR2G    polymerase (RNA) II (DNA directed) polypeptide G                        0.9096222         7079.79    7783.22    1.1617413   7739.16    6661.69    1.1016729    19641.66
                                                           Human RNA polymerase II subunit (hsRPB8) mRNA; polymerase (RNA) II (DNA
                     <671>POLR2H     U37689      POLR2H                                                                        1.7274708             7540.79    4365.22    1.8397554   12270.69   6669.74     1.554472    8537.16
                                                                      directed) polypeptide H
                     <1148>POLR2I    NM_006233   POLR2I    polymerase (RNA) II (DNA directed) polypeptide I (14.5kD)               1.0709902         1122.13    1047.75    2.7029788   2020.72     747.59    1.7946482    3051.53
                     <1126>POLR2J    L37127      POLR2J    polymerase (RNA) II (DNA directed) polypeptide J (13.3kD)               1.1694163         1465.15    1252.89    1.5446728   6550.71    4240.84    1.2982823    13870.25
                     <1158>POLR2K    Z47727      POLR2K    polymerase (RNA) II (DNA directed) polypeptide K (7.0kD)                 1.243185          132.71     106.75    2.0842242    804.99     386.23    1.6232091    1562.29
                     <1038>POLR2L    U37690      POLR2L    polymerase (RNA) II (DNA directed) polypeptide L (7.6kD)                1.1113924          724.35     651.75    1.549562     1713.8    1105.99    1.8097718    7433.04
                     <798>POLRMT     U75370      POLRMT    polymerase (RNA) mitochondrial (DNA directed)                           1.0796703         10391.61    9624.8    1.5063131   15819.36   10502.04   1.2537216    14260.03
                                                           Homo sapiens proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-
                     <1428>POMC      NM_000939   POMC                                                                                1.0021105
                                                                      melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-       432.1     431.19    3.4762805    719.59       207     0.5642986     171.97
                                                                                   endorphin) (POMC)
                                                           Human mRNA for octamer-binding protein Oct-1; POU domain, class 2,
                     <30>POU2F1      X13403      POU2F1                                                                              1.1445557       2571.13     2246.4    1.761663    4645.84    2637.19    1.4222156     3874.3
                                                                     transcription factor 1
                                                           Human lymphoid-specific transcription factor mRNA; POU domain, class 2,
                     <882>POU2F2     M36542      POU2F2                                                                              1.1798208       2858.47     2422.8    3.119411    12498.45   4006.67    1.5871929    10683.03
                                                                       transcription factor 2
                     <894>POU5F1     Z11898      POU5F1    H.sapiens OTF3 mRNA encoding octamer binding protein 3A                0.45952082          896.81    1951.62    0.7169454   1406.69    1962.06    1.0598288    5136.47

                     <849>PPARA      L02932      PPARA     Human peroxisome proliferator activated receptor mRNA, complete cds      0.794706         3227.19    4060.86    0.7164515   5010.69    6993.76 0.91225034      5820.34

                     <787>PPARD      L07592      PPARD     Human peroxisome proliferator activated receptor mRNA, complete cds     1.1141623         7647.02    6863.47    0.8494397   2079.25    2447.79 0.87865895      8263.19

                     <1226>PPARG     L40904      PPARG     H. sapiens peroxisome proliferator activated receptor gamma, complete cds1.2547013         194.83     155.28                                      1.2963415     212.25
Molecular Medicine




                     <1048>PPARG2    U63415      PPARG2                                                                         1.4199823
                                                           Human peroxisome proliferator activated receptor gamma 2 mRNA, complete cds                177.37     124.91                                      0.71196795    294.89
                                                           Human calmodulin-dependent protein phosphatase catalytic subunit (PPP3CA)
                     <145>PPP3CA     L14778      PPP3CA                                                                         0.69885385           10866.73   15549.36 0.89031196    39985.88   44912.21   0.9496172    39516.84
                                                                     mRNA, complete cds and alternative exon
                     <240>PPP3CB     M29551      PPP3CB    Human calcineurin A2 mRNA;                                             0.90815055         3776.98    4158.98 0.58088446     1379.74    2375.24 0.72136664      7034.58
                                                           calcineurin A catalytic subunit [human, testis, mRNA, 2134 nt]; Protein
                     <577>PPP3CC     S46622      PPP3CC                 phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform1.0453035 A
                                                                                                                                      (calcineurin   2873.56    2749.02    1.3536085   19055.49   14077.55   1.2302943    39556.29
                                                                                        gamma)
                     <1472>PRDX2     BC003022    PRDX2     peroxiredoxin 2                                                         1.4191917         13145.93   9262.97    2.257609    13777.51    6102.7    1.0449245    66744.51
                     <1643>PRDX4     BC003609    PRDX4     peroxiredoxin 4                                                          2.301869         3964.67    1722.37    1.5487587   4122.13    2661.57     1.517306    8262.96
                     <1463>PRDX5     AF242525    PRDX5     peroxiredoxin 5                                                         2.2288508         23438.06   10515.76   3.810368    42003.17   11023.39   1.6274096    42921.61
                     <1549>PREB      BC008658    PREB      prolactin regulatory element binding                                     1.343872         1632.24    1214.58    1.8225263   2933.83    1609.76    1.1325243    18929.85

                     <476>PRKCA      X52479      PRKCA                                                                           0.93845135
                                                           Human PKC alpha mRNA for protein kinase C alpha; Protein kinase C, alpha                  1821.29    1940.74 0.68075854     1049.26    1541.31    0.7704524     345.91
                                                           Novel human mRNA similar to mouse gene PICK1 Protein kinase C, alpha
                     <1133>PRKCABP   AL049654    PRKCABP                                                                        1.5849427              80.42      50.74                                      1.4004346     554.25
                                                                     binding protein
                     <327>PRKCB1    X06318      PRKCB1                                                                             1.0616577
                                                          Human mRNA for protein kinase C (PKC) type beta I.; Protein kinase C, beta 1          15034.24   14161.1    0.7626453   20087.13    26338.76   0.9655382    23073.12




                                                                                                                                                                                                                                 UNCORRECTED PROOF
                                                          Homo sapiens protein kinase C-binding protein RACK7 mRNA, partial cds;
                     <594>PRKCBP1   U48251      PRKCBP1                                                                          1.0735688      2661.86    2479.45    1.1752626    2486.55    2115.74     0.969541    7293.77
                                                                    Protein kinase C binding protein 1
                                                          Human protein kinase C-binding protein RACK17 mRNA, partial cds; Protein
                     <515>PRKCBP2   U48250      PRKCBP2                                                                           1.328173       354.33     266.78    6.1889753     367.13      59.32    0.43928856   1996.36
                                                                    kinase C binding protein 2

                     <978>PRKCD     D10495      PRKCD                                                                              0
                                                          Homo sapiens mRNA for protein kinase C delta-type; Protein kinase C, delta .6245662     7190     11511.99 0.50590396     2344.43    4634.14 0.71759856      8722.74

                     <899>PRKCE     X65293      PRKCE     H.sapiens mRNA for protein kinase C-Epsilon; Protein kinase C, epsilon 0.11863612       17.71     149.28    26.729729      89.01       3.33    0.8351038    1353.72
www.molmed.org




                     <1116>PRKCG    Z15114      PRKCG                                                                             0.77284914
                                                          H.sapiens mRNA for protein kinase C gamma (partial); Protein kinase C, gamma           221.97     287.21    1.3058013     219.91     168.41

                     <448>PRKCH     M55284      PRKCH     Human protein kinase C-L (PRKCL) mRNA; Protein kinase C, eta           0.9690219      10397.13   10729.51 0.65861183    12582.16    19104.06   0.7994561    9963.75

                     <178>PRKCI     L18964      PRKCI     Human protein kinase C iota isoform (PRKCI) mRNA; Protein kinase C, iota0.9155828     1036.22    1131.76    0.9589824     2852.1    2974.09    0.8266866    2335.77

                     <197>PRKCL2    U33052      PRKCL2    Human lipid-activated, protein kinase PRK2 mRNA; Protein kinase C-like 2 0.5750537    3647.37    6342.66 0.36473876      4135.24    11337.54 0.52346945     14629.05

                     <347>PRKCM     X75756      PRKCM     H.sapiens mRNA for protein kinase C mu; Protein kinase C, mu           1.3979586       250.64     179.29 0.64310294       151.38     235.39     1.232811     610.34

                     <186>PRKCN     AB015982    PRKCN                                                                            1.2209942
                                                          Homo sapiens EPK2 mRNA for serine/threonine kinase; Protein kinase C, nu              2928.97    2398.84    0.7441888    3407.38    4578.65     1.012267    5074.96

                     <449>PRKCQ     L07032      PRKCQ     Human protein kinase C theta (PKC) mRNA; Protein kinase C, theta       1.1073312      2083.51    1881.56    0.6427477    3696.23    5750.67    0.7672462    6067.82
                                                          Human 80K-H protein (kinase C substrate) mRNA; Protein kinase C substrate 80K-
                     <745>PRKCSH    J03075      PRKCSH                                                                         0.27455053        352.91    1285.41    1.0306216    1235.87    1199.15    2.9958963    3343.33
                                                                      H
                     <900>PRKCZ     Z15108      PRKCZ     H.sapiens mRNA for protein kinase C zeta; Protein kinase C, zeta      0.93686604       1251.7    1336.05 0.59261125        704.2     1188.3    0.79337883   2080.16
                                                          Homo sapiens DNA-dependent protein kinase catalytic subunit (DNA-PKcs)
                     <408>PRKDC     U47077      PRKDC                                                                          0.5495752        1339.54    2437.41 0.68260354      3009.64    4409.06    0.7462026    3155.84
                                                                     mRNA
                     <1557>PRL      M29386      PRL       prolactin                                                              1.0282602      2323.58    2259.72    1.0293463    2211.18    2148.14    1.2357785    2255.79
                     <1590>PRLR     NM_000949   PRLR      prolactin receptor                                                     3.1954858      10951.44   3427.16    1.2342119    5666.23    4590.97    1.3396182    9749.34
                     <1631>PRSS11   Y07921      PRSS11    protease, serine, 11 (IGF binding)                                     1.9665592       586.31     298.14    0.9954501     802.93      806.6    0.7298663     703.27
                     <1642>PSMA1    BC002577    PSMA1     proteasome (prosome, macropain) subunit, alpha type, 1                  1.088581      1818.91     1670.9    1.4285752    4903.27    3432.28    1.1453754    5198.55
                     <1682>PSMA2    BC002900    PSMA2     proteasome (prosome, macropain) subunit, alpha type, 2                  2.017655       609.13      301.9    1.7385786    1615.07     928.96    1.2668049    1044.43
                     <1711>PSMA3    BC005265    PSMA3     proteasome (prosome, macropain) subunit, alpha type, 3                 2.1159785      25510.64   12056.19   1.4936178    19192.3    12849.54   2.2843232    46582.15
                     <1696>PSMA4    BC005361    PSMA4     proteasome (prosome, macropain) subunit, alpha type, 4                  3.472361      12558.21   3616.62    2.3762987   26958.56    11344.77   2.4830768    91117.35
                     <1639>PSMA5    X61970      PSMA5     proteasome (prosome, macropain) subunit, alpha type, 5                 1.1477416      24085.23   20984.89   1.4175109    29643.3    20912.22   1.2183654    37358.42
                     <1710>PSMA6    X59417      PSMA6     proteasome (prosome, macropain) subunit, alpha type 6                  2.9689949      16716.39   5630.32    2.6149385   15792.32    6039.27     2.333502    37467.34
                     <1687>PSMA7    BC004427    PSMA7     proteasome (prosome, macropain) subunit, alpha type, 7                 1.4602783      44253.88   30305.1    1.8522167   119056.75   64277.98   1.4602342    93272.4
Molecular Medicine




                     <1635>PSMB1    BC000508    PSMB1     proteasome (prosome, macropain) subunit, beta type, 1                  1.5286201      23049.36   15078.54   1.7014701   29454.71    17311.33   1.5605218    46064.86
                     <1488>PSMB10   Y13640      PSMB10    proteasome (prosome, macropain) subunit, beta type, 10                  1.204215      2635.28    2188.38    1.7734427    1087.28     613.09    1.3425715    5767.66
                     <1583>PSMB2    BC000268    PSMB2     proteasome (prosome, macropain) subunit, beta type, 2                  0.8853908      12498.69   14116.58   0.845583     8044.64    9513.72    1.2320795    13821.32
                     <1509>PSMB3    NM_002795   PSMB3     proteasome (prosome, macropain) subunit, beta type, 3                 0.94575655       5695.8    6022.48 0.95659745      13888.8    14518.96   1.3436023    34597.41
                     <1647>PSMB4    S71381      PSMB4     proteasome (prosome, macropain) subunit, beta type, 4                  1.1755265      52762.9    44884.48   1.6566248     76608     46243.42   1.4957445    95540.62
                     <1641>PSMB5    BC004146    PSMB5     proteasome (prosome, macropain) subunit, beta type, 5                  1.2001424      8160.02    6799.21    1.4627265   14524.83    9929.97    1.3836758    36633.83
                     <1528>PSMB6    BC000835    PSMB6     proteasome (prosome, macropain) subunit, beta type, 6                  1.7848575      5709.01    3198.58    1.680286     8882.58    5286.35    1.5852112    27858.47
                     <1534>PSMB7    BC000509    PSMB7     proteasome (prosome, macropain) subunit, beta type, 7                  1.8063866      10242.14   5669.96    1.7975953   20030.12    11142.73   1.5047696    96117.09
                                                          proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional
                     <1544>PSMB8    BC001114    PSMB8                                                                              0.56123763   4456.99    7941.36    1.2470511    7290.76     5846.4 0.88808894       2067.4
                                                                      protease 7)
                                                          proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional
                     <1609>PSMB9    BC008795    PSMB9                                                                               1.1749082   17035.17   14499.15   1.3799974   29259.23    21202.38   1.3656684    34105.81
                                                                      protease 2)
                     <484>PSMC1     L02426      PSMC1     Proteasome (prosome, macropain) 26S subunit, ATPase, 1                 1.3640736      14999.94   10996.43   1.0051126    41711.3    41499.13   1.0944295    35974.48
                     <569>PSMC2     D11094      PSMC2     Proteasome (prosome, macropain) 26S subunit, ATPase, 2                 3.2703004       589.21     180.17    2.1008375    7164.99    3410.54    1.4894892    43088.94
                     <877>PSMC3     M34079      PSMC3    Proteasome (prosome, macropain) 26S subunit, ATPase, 3              1.4317546        1203.49      840.57    1.2940953    5402.33     4174.6    1.0892854   6564.23




                                                                                                                                                                                                                               UNCORRECTED PROOF
                     <889>PSMC4     AF020736    PSMC4    Proteasome (prosome, macropain) 26S subunit, ATPase, 4              0.9459917        2586.19     2733.84    1.2361313    16430.25   13291.67   1.0896553   49999.91
                     <822>PSMC5     AF035309    PSMC5    Proteasome (prosome, macropain) 26S subunit, ATPase, 5               1.246759        2498.53     2004.02     1.174801    4840.92    4120.63    1.1926833   7333.19
                     <118>PSMC6     AF006305    PSMC6    Proteasome (prosome, macropain) 26S subunit, ATPase, 6               2.864693        7464.76     2605.78    1.3896267    27494.82   19785.76   1.8661025   89522.42
                     <1598>PSMD1    NM_002807   PSMD1    proteasome (prosome, macropain) 26S subunit, non-ATPase, 1          1.3759725       28499.09     20711.96   1.2088177    33116.99   27396.18   1.3383069   35237.49
                     <1608>PSMD10   NM_002814   PSMD10   proteasome (prosome, macropain) 26S subunit, non-ATPase, 10         1.9634634        3603.78     1835.42    1.1566571    5974.77    5165.55 0.73028547     5001.28
www.molmed.org



                     <1650>PSMD11   BC004430    PSMD11   proteasome (prosome, macropain) 26S subunit, non-ATPase, 11         1.2983142       32239.92     24832.14   1.7904797    47172.94   26346.54   1.0970547   70074.33
                     <1699>PSMD13   BC001100    PSMD13   proteasome (prosome, macropain) 26S subunit, non-ATPase, 13          1.123341       15341.49     13657.02 0.91207534     11352.2    12446.56   1.055227    33222.79
                     <1526>PSMD2    BC007897    PSMD2    proteasome (prosome, macropain) 26S subunit, non-ATPase, 2          1.1527559       12487.09     10832.38     1.16832    12112.72   10367.64 0.79132164    30873.43
                     <1489>PSMD3    NM_002809   PSMD3    proteasome (prosome, macropain) 26S subunit, non-ATPase, 3         0.74762696        5039.97     6741.29    1.3944212    2226.04    1596.39    1.1922666    4641.1
                     <1537>PSMD4    AB033605    PSMD4    proteasome (prosome, macropain) 26S subunit, non-ATPase, 4          1.3529859        4320.99     3193.67 0.98666686      1695.37    1718.28    1.1928463   7731.97
                     <1686>PSMD5    D31889      PSMD5    proteasome (prosome, macropain) 26S subunit, non-ATPase, 5           1.201197       19334.66     16096.16   1.1493497    21293.99   18526.99   0.9985655   26313.37

                     <1674>PSMD7    NM_002811   PSMD7                                                                        1.0334921
                                                         proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)          23255.97     22502.32   1.1213078    26243.66   23404.51   1.0734916   40572.87

                     <1496>PSMD8    BC001164    PSMD8    proteasome (prosome, macropain) 26S subunit, non-ATPase, 8          1.2776715        1802.36     1410.66    1.3132528    3483.18    2652.33    1.3678737   17796.68
                     <1603>PSMD9    BC004213    PSMD9    proteasome (prosome, macropain) 26S subunit, non-ATPase, 9          2.3102455        8218.26     3557.31     2.833443     9540.6    3367.14    1.471184    3452.31
                     <1563>PSME1    BC007503    PSME1    proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)   0.77361447       64923.16     83921.85   1.3224664    85026.03   64293.53   1.2166431   77713.03
                     <1570>PSME2    BC004368    PSME2    proteasome (prosome, macropain) activator subunit 2 (PA28 beta)     0.8347658       28028.68     33576.7    1.6576786    56993.23   34381.35   1.491993    84821.17
                     <1636>PSMF1    NM_006814   PSMF1    proteasome (prosome, macropain) inhibitor subunit 1 (PI31)          1.5365298       18035.25     11737.65   1.8183043    34818.11   19148.67   0.8318826   53388.26
                                                         Human mutated in multiple advanced cancers protein (MMAC1) mRNA; putative
                     <279>PTEN      U92436      PTEN                                                                         1.0519948       10176.44     9673.47    0.4889649    7368.07    15068.71 0.91158193    7896.66
                                                                   protein-tyrosine phosphatase PTEN
                     <1541>PTGDR    U31099      PTGDR    prostaglandin D2 receptor (DP)                                      1.9045057         711.39      373.53 0.14936154        42.81     286.62 0.91693074     3069.71
                     <1454>PTGDS    BC005939    PTGDS    prostaglandin D2 synthase (21kD, brain)                             1.4972668          983.3      656.73    0.2166434     1131.6    5223.33 0.87394214     6297.19
                     <1483>PTGER1   NM_000955   PTGER1   prostaglandin E receptor 1 (subtype EP1), 42kD                      1.4822277       12782.05     8623.54    1.5561023    14109.04   9066.91    1.2155007   25558.43
                     <1591>PTGER2   U19487      PTGER2   prostaglandin E receptor 2 (subtype EP2), 53kD                     0.92214584       17467.26     18941.97   0.6957853    7636.89    10975.93   1.151481    12980.6
                     <1679>PTGER3   X83860      PTGER3   prostaglandin E receptor 3 (subtype EP3)                            2.4844363        1930.73      777.13    4.2095695     3125.9     742.57    3.1672196   2385.93
                     <1545>PTGER4   NM_000958   PTGER4   prostaglandin E receptor 4 (subtype EP4)                           0.68994045          583.8      846.16    0.4980321     521.34     1046.8    0.4482931    959.93
                                                         Homo sapiens microsomal glutathione S-transferase 1-like 1(MGST1L1) mRNA;
                     <817>PTGES     AF027740    PTGES                                                                         1.0251665        334.03      325.83    1.2170788      379.4     311.73    1.210155    2298.52
                                                                    Prostaglandin E synthase
                     <1646>PTGFR    NM_000959   PTGFR    prostaglandin F receptor (FP)                                       1.1773378         486.37      413.11    0.92573535    456.98     493.64    1.4352769    924.39
Molecular Medicine




                     <1705>PTGFRN   AB037857    PTGFRN   prostaglandin F2 receptor negative regulator                        0.9884824        7385.98     7472.04    1.0295733    6366.49    6183.62    1.1342185   10299.61
                     <1576>PTGIR    D25418      PTGIR    prostaglandin I2 (prostacyclin) receptor (IP)                       0.4807173       13265.73     27595.7    0.9037163    11527.39   12755.54   1.3063734   28834.94
                                                         prostaglandin G/H synthase 1 precursor (PGH synthase 1; PGHS1; PTGS1);
                     <562>PTGS1     M59979      PTGS1                                                                           0.9381058       5809.53   6192.83    1.0086673    13586.85   13470.1 0.99452084     8993.79
                                                                       cyclooxygenase 1 (COX1)
                                                         prostaglandin G/H synthase 2 precursor (PGH synthase 2; PGHS2; PTGS2);
                     <242>PTGS2     M90100      PTGS2                                                                          0.43684226        602.27   1378.69                                       0.4275231    618.72
                                                                       cyclooxygenase 2 (COX2)
                                                         Homo sapiens SH-PTP3 mRNA for protein-tyrosine phosphatase; Protein tyrosine
                     <115>PTPN11    D13540      PTPN11                                                                          1.0535223       2044.75   1940.87 0.91975576      1644.79    1788.29    0.777985    2915.95
                                                                       phosphatase, non-receptor type 11; Shp2
                                                         Human mRNA for protein tyrosine phosphatase (PTP-BAS, type 2); Protein tyrosine
                     <180>PTPN13    D21210      PTPN13                                                                          0.7807488        352.43
                                                                        phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase);        451.4    0.7980172     579.56     726.25 0.80996424      565.76
                                                                                      FAP
                                                         H.sapiens PTP1C mRNA for protein-tyrosine phosphatase 1C.; Protein tyrosine
                     <903>PTPN6     X62055      PTPN6                                                                           0.6514779       9067.36   13918.14   1.1753209    31445.71     26755    1.0488391   37204.62
                                                                      phosphatase, non-receptor type 6; SHP-1
                                                         Human mRNA for protein-tyrosine phosphatase; Protein tyrosine phosphatase,
                     <800>PTPN7     D11327      PTPN7                                                                            0.956695       3691.14   3858.22    0.8029757    4093.04    5097.34    1.1225404   4793.64
                                                                      non-receptor type 7, HePTP
                     <322>PTPRC     Y00062      PTPRC    Human mRNA for T200 leukocyte common antigen (CD45, LC-A).           0.972809       64923.16     66737.83 0.34530523     24793.9    71802.85 0.70263565    57127.76
                                                         Homo sapiens herpesvirus entry protein C (HVEC) mRNA; Poliovirus receptor-
                     <1107>PVRL1    AF060231    PVRL1                                                                           3.999672       122.07       30.52    0.8368408     283.12     338.32 0.86490464      381.89
                                                                     related 1 (herpesvirus entry mediator C; nectin)
                     <649>RAB1     M28209      RAB1     Homo sapiens GTP-binding protein (RAB1) mRNA, complete cds.           0.8485229      7564.98    8915.47 0.53128886     11929.9    22454.64 0.72559446    27731.21




                                                                                                                                                                                                                            UNCORRECTED PROOF
                     <112>RAB11A   AF000231    RAB11A   Homo sapiens rab11a GTPase mRNA, complete cds.                       0.96937865      7449.84    7685.17    1.0125138   24667.71   24362.84 0.92133904    63034.83
                     <953>RAB13    X75593      RAB13    H.sapiens mRNA for rab 13                                             1.0585861       946.81     894.41    1.2871174   1910.61    1484.41    1.6759592   2879.65
                     <426>RAB33A   D14889      RAB33A   Human mRNA for small GTP-binding protein, S10, complete cds           1.3764949      1671.23    1214.12    1.2579124   2943.88    2340.29    1.159081    3848.52
                     <503>RAB4     M28211      RAB4     Homo sapiens GTP-binding protein (RAB4) mRNA, complete cds.           1.5559608      3869.69    2487.01    1.0872008   8258.29    7595.92    1.0990535   28346.83
                     <650>RAB5A    M28215      RAB5A    Homo sapiens GTP-binding protein (RAB5) mRNA, complete cds.          0.77284956       870.53    1126.39 0.34532607      402.26    1164.87 0.47461936     1677.02
www.molmed.org



                     <904>RAB5B    X54871      RAB5B    H.sapiens mRNA for ras-related protein Rab5b                         0.45689297      1035.58    2266.57 0.56277806     1860.91    3306.65 0.67534846     2327.71
                     <126>RAB7L1   D84488      RAB7L1   Homo sapiens mRNA for small GTP-binding protein, complete cds         0.9478565      2982.44    3146.51    1.0304819   4815.37    4672.93    0.8543027   51498.57
                     <678>RAB9     U44103      RAB9     Human small GTP binding protein Rab9 mRNA, complete cds.             0.71151495      3007.78    4227.29 0.75298387     3763.21    4997.73 0.86503005     3646.56
                                                        Human ras-related C3 botulinum toxin substrate (rac) mRNA ras-related C3
                     <1085>RAC1    M29870      RAC1                                                                              1.1476065   49167.7    42843.69   1.5990143   93327.69   58365.76   1.2150489   77611.2
                                                                    botulinum toxin substrate 1; p21-rac1; ras-like protein TC25
                                                        Human ras-related C3 botulinum toxin substrate (rac) mRNA; p21-rac2; small G
                     <1086>RAC2    M29871      RAC2                                                                              0.7280923   3220.76    4423.56 0.44332346      772.07    1741.55    0.9214072   2734.11
                                                                     protein
                     <296>RAD50    Z75311      RAD50    RAD50 (S. cerevisiae) homolog                                         1.7602824      1026.72     583.27    0.3196725      139      434.82 0.03208227       36.03
                     <835>RAD51C   AF029670    RAD51C   RAD51 (S. cerevisiae) homolog C                                       2.0478942        602.9      294.4    1.4600291    983.68     673.74    1.8752016   5720.49
                     <169>RAD53    AF086904    RAD53    Protein kinase Chk2                                                  0.57985896       669.54    1154.66                                      1.1500814    134.18
                                                        Human mRNA for raf oncogene, v-raf-1 murine leukemia viral oncogene
                     <905>RAF1     X03484      RAF1                                                                         0.84153336       10930.13   12988.35   0.6695454   20209.17   30183.42 0.92639965    34346.88
                                                                homolog 1
                     <566>RALB     M35416      RALB     Human GTP-binding protein (RALB) mRNA, complete cds.                  0.5724004      18152.55   31713.03 0.41030443    13883.15   33836.22 0.37779665    14847.59
                     <373>RAP1A    M22995      RAP1A    Human ras-related protein (Krev-1) mRNA, complete cds                 1.0409957      25028.69   24043.03 0.54449594    42981.22   78937.63 0.69574845    50174.63
                     <253>RASA1    M23379      RASA1    Human GTPase-activating protein ras p21 (RASA) mRNA; GAP              1.0310553      7282.88    7063.52    0.8254978   8733.42    10579.58   1.0149103    9335.5

                     <857>RASSF1   AF061836    RASSF1                                                                       1.0689304
                                                        Homo sapiens putative tumor suppressor protein (RDA32) mRNA, complete cds            3189.25    2983.59 0.64668375     5172.61    7998.67    1.5136513   23431.67

                     <278>RB1      M15400      RB1      Human retinoblastoma susceptibility mRNA, complete cds (RB1)         0.36214393       886.76    2448.64    0.5305486   1035.27    1951.32    0.3724712    674.05
                     <355>RBBP1    NM_002892   RBBP1    Homo sapiens retinoblastoma-binding protein 1 (RBBP1) mRNA            1.3067483      3538.23    2707.66 0.45797607     2460.71    5373.01    0.8256789   14283.56
                                                        RBP2=retinoblastoma binding protein 2 [human, Nalm-6 pre-B cell leukemia,
                     <630>RBBP2    S66431      RBBP2                                                                          0.95475554     8161.46    8548.22    0.8115999   3528.82    4347.98    1.0788577   4848.57
                                                                   mRNA, 6455 nt].
                                                        Human chromatin assembly factor 1 p48 subunit (CAF1 p48 subunit);
                     <337>RBBP4    X74262      RBBP4                                                                           1.1610695     11830.23   10189.08   1.0904299   23715.51   21748.77   1.1157888   31074.24
                                                                  retinoblastoma-binding protein 4
                     <1247>RBBP5   X85134      RBBP5    H.sapiens RBQ-3 mRNA                                                 0.95505077      21299.56   22302.02   0.7795589   18303.91   23479.83   0.9559907   11748.16
                     <395>RBBP6    X85133      RBBP6    H.sapiens RBQ-1 mRNA                                                 0.81249017       5881.6    7238.98    1.5019681   11790.57   7850.08 0.85533386     20098.13
                     <198>RBBP7    U35143      RBBP7    Human retinoblastoma-binding protein (RbAp46) mRNA, complete cds      1.0981983      30805.54   28050.98   1.0952181   40287.98   36785.35   1.0229638   49204.99
Molecular Medicine




                     <160>RBBP8    AF043431    RBBP8                                                                         1.0097755
                                                        Homo sapiens retinoblastoma-interacting protein (RBBP8) mRNA, complete cds            586.72     581.04    1.0015833   2435.56    2431.71    1.0400904    6450.1

                     <888>RBBP9    AF039564    RBBP9                                                                         1.5515579
                                                        Homo sapiens retinoblastoma binding protein (RBBP9) mRNA, complete cds.               534.31     344.37

                     <140>RBL1     L14812      RBL1     Human retinoblastoma related protein (p107) mRNA; Retinoblastoma-like 11.1366999       176.7     155.45 0.65677726      676.96    1030.73    0.6907576     939.9
                                                        Human retinoblastoma-like protein 2 (RBL2; RB2); 130-kDa retinoblastoma-
                     <621>RBL2     X74594      RBL2                                                                            1.0461211     5158.57    4931.14    0.3780184   5543.61    14664.92   0.4970985   14510.43
                                                                   associated protein (p130)
                     <451>RDS      M73531      RDS      Retinal degeneration, slow (retinitis pigmentosa 7)                   1.1632609      2805.39    2411.66    1.2223903   6301.41    5154.99    1.731659    7867.17
                     <338>REL      X75042      REL      H.sapiens rel proto-oncogene mRNA                                    0.65186757        2521     3867.35 0.76382834     3625.45    4746.42    0.5423861   3460.89

                     <74>RELA      L19067      RELA     Human NF-kappa-B transcription factor p65 subunit mRNA, complete cds.0.88908803       3522.3     3961.7    0.8731854   1576.51    1805.47    0.9071953   1607.16

                     <767>RELB     M83221      RELB     Homo sapiens I-Rel mRNA, complete cds.                                0.8911368       891.52    1000.43    1.3667924    761.44      557.1    0.8173065   3398.05
                     <1389>REN     NM_000537   REN      Homo sapiens renin (REN)                                                    1.95        8.97        4.6

                     <68>RGS14     AF037195    RGS14                                                                        0.95382595
                                                        Homo sapiens regulator of G protein signaling RGS14 mRNA, complete cds.              1931.86    2025.38 0.84075505     3473.26    4131.12 0.99150896     30955.97
                                                        Homo sapiens RIP protein kinase mRNA, Receptor (TNFRSF)-interacting serine-
                     <474>RIPK1    U50062      RIPK1                                                                        0.36262855        388.27    1070.71 0.32736233      427.09    1304.64 0.59419197      631.43
                                                                   threonine kinase 1
                     <1194>RIPK2    AF027706   RIPK2    Homo sapiens serine/threonine kinase RICK (RICK) mRNA; RIP2           0.50911725      499.78     981.66 0.55205905     1759.39    3186.96    0.7309881    2807.82




                                                                                                                                                                                                                             UNCORRECTED PROOF
                     <471>RPA1      M63488     RPA1     Replication protein A1 (70kD)                                          0.856572      3427.35    4001.24 0.72362727     4902.77    6775.27 0.81603396      6396.89
                     <805>RPA40     AF008442   RPA40    RNA polymerase I subunit                                              1.1018085      7189.62    6525.29    1.6716527   19572.68   11708.58   1.4781249    16381.91
                     <459>RPC155    AF021351   RPC155   polymerase (RNA) III (DNA directed) (155kD)                           0.90764153      607.43     669.24    0.9489084   1228.77    1294.93 0.76965004      2652.06
                     <287>RPC32     U93868     RPC32    polymerase (RNA) III (DNA directed) (32kD)                            1.3732166       602.54     438.78 0.77703285      435.76      560.8    1.8200983     480.87
                     <288>RPC39     U93869     RPC39    polymerase (RNA) III (DNA directed) (39kD)                            1.2147374      3242.45    2669.26 0.84126633      2713.9    3225.97    0.8658178    2395.51
www.molmed.org



                     <456>RPC62     U93867     RPC62    polymerase (RNA) III (DNA directed) (62kD)                            1.2499905      4558.74    3647.02    1.2438978   6824.62    5486.48    1.0428222    7778.38
                     <595>RS1       AF014459   RS1      retinoschisis (X-linked, juvenile) 1                                  1.7639984         396      224.49    1.0543951   1363.47    1293.13 0.98446745      7202.63
                                                        Human AML1 mRNA for AML1b protein (alternatively spliced product),complete
                     <196>RUNX1     D43968     RUNX1                                                                          0.7070382      3631.03    5135.55 0.86971265     6168.15    7092.17     0.906531    17814.45
                                                                  cds
                     <1117>RXRA     X52773     RXRA     Human mRNA for retinoic acid receptor-like protein                    0.9190072      5942.42    6466.13     1.81351    21422.83   11812.91   1.3196357    20000.03
                     <873>RXRB      M84820     RXRB     Human retinoid X receptor beta (RXR-beta) mRNA, complete cds          0.80699795      920.93    1141.18    0.6374263   1140.77    1789.65    0.8460448    2057.53
                     <1039>RXRG     U38480     RXRG     Human retinoid X receptor-gamma mRNA, complete cds                    1.5601169      7314.14     4688.2    1.4601278   14801.17   10136.9    1.1934923    23173.6
                     <1460>S100A6   BC001431   S100A6   S100 calcium-binding protein A6 (calcyclin)                           1.0825477      15703.87   14506.4    1.406353    15587.2    11083.42   1.3359773    85335.5
                                                        Human secreted protein (I-309) mRNA; Small inducible cytokine A1 (I-309,
                     <1113>SCYA1    M57502     SCYA1                                                                             1.0671303    296.15     277.52    1.0186092   1048.76     1029.6    0.9877148    1342.66
                                                                     homologous to mouse Tca-3)
                                                        Human mRNA for eotaxin; Small inducible cytokine subfamily A (Cys-Cys),
                     <524>SCYA11    D49372     SCYA11                                                                            1.2607636   1038.68     823.85    1.2729892    941.35     739.48    1.1595353     340.37
                                                                     member 11 (eotaxin)
                                                        Human monocyte chemotactic protein-4 precursor (MCP-4) mRNA; Small
                     <624>SCYA13    U59808     SCYA13                                                                            1.4312238    456.36     318.86    1.4975759   11428.75    7631.5    1.2365063    8954.47
                                                                     inducible cytokine subfamily A (Cys-Cys), member 13
                                                        H.sapiens mRNA for chemokine HCC-1; Small inducible cytokine subfamily A
                     <1035>SCYA14   Z49270     SCYA14                                                                            1.4630296    625.65     427.64    1.6723204    592.57     354.34 0.73861563       517.09
                                                                    (Cys-Cys), member 14
                                                        Homo sapiens MIP-1 delta mRNA; Small inducible cytokine subfamily A (Cys-Cys),
                     <1188>SCYA15   AF031587   SCYA15                                                                            0.7704939   1694.74    2199.55    1.2567323   7881.17    6271.16    1.2059437    9632.97
                                                                       member 15
                                                        Homo sapiens liver CC chemokine-1 precursor (SCYA16) mRNA; Small inducible
                     <623>SCYA16    AF039955   SCYA16                                                                            1.1280392    427.29     378.79    1.5343939    663.61     432.49    0.7888992     648.27
                                                                      cytokine subfamily A, member 16
                                                        Human mRNA for chemokine; Small inducible cytokine subfamily A (Cys-Cys),
                     <1172>SCYA17   D43767     SCYA17                                                                           0.36460218     62.46     171.31                                      0.74030423    293.96
                                                                      member 17
                                                        Homo sapiens mRNA for alternative activated macrophage specific CC
                     <572>SCYA18    Y13710     SCYA18                                                                            1.0569092
                                                                   chemokine 1; Small inducible cytokine subfamily A (Cys-Cys), member 18,     2991     2829.95    0.941384    2449.18    2601.68     1.094605    1583.97
                                                                                 pulmonary and activation-regulated
                                                        Human macrophage inflammatory protein 3 beta (MIP-3beta), Small inducible
                     <1060>SCYA19   U77180     SCYA19                                                                           0.58056825    202.09     348.09                                      0.63462085    267.81
                                                                    cytokine subfamily A (Cys-Cys), member 19
                     <573>SCYA2     S71513     SCYA2    monocyte chemoattractant protein-1 [human, mRNA, 739 nt], MCP-1       0.7194824       265.23     368.64    1.0207529    378.24     370.55 0.60830814      1025.79
                                                        Human macrophage inflammatory protein 3 alpha (MIP-3a) mRNA; Small
                     <533>SCYA20    U77035     SCYA20                                                                          7.030188        74.52       10.6    1.5404792    264.87     171.94    0.8340188     725.93
                                                                  inducible cytokine subfamily A (Cys-Cys), member 20
Molecular Medicine




                                                        Homo sapiens beta chemokine mRNA; Small inducible cytokine subfamily A (Cys-
                     <819>SCYA21    AF001979   SCYA21                                                                         1.0015445      1309.87    1307.85 0.98712564      903.22       915     0.9802278     2900.7
                                                                    Cys), member 21
                                                        Human macrophage-derived chemokine precursor (MDC) mRNA; Small
                     <1186>SCYA22   U83171     SCYA22                                                                       0.71361864          298      417.59 0.82642925        803      971.65 0.50764513       542.83
                                                                  inducible cytokine subfamily A (Cys-Cys), member 22
                                                        Human chemokine (hmrp-2a) mRNA; small inducible cytokine subfamily A (Cys-
                     <1127>SCYA23   U58913     SCYA23                                                                         0.8752418      1112.94    1271.58    1.2894171   2203.24    1708.71    1.1686764    1737.74
                                                                    Cys), member 23
                     <1088>SCYA24   U85768     SCYA24   Human myeloid progenitor inhibitory factor-1 MPIF-2 mRNA              1.0973662       303.74     276.79
                                                        Homo sapiens mRNA for CC chemokine eotaxin3;Small inducible cytokine
                     <1149>SCYA26   AB010447   SCYA26                                                                        1.9726353        157.87      80.03    3.9157722    116.69       29.8
                                                                  subfamily A (Cys-Cys), member 26
                                                        Human macrophage inflammatory protein (G0S19-1) mRNA, Small inducible
                     <777>SCYA3     M23452     SCYA3                                                                         1.1132267       5690.67    5111.87    1.0223343   9843.26    9628.22    1.9679675    27830.74
                                                                   cytokine subfamily A (Cys-Cys), member 3; Mip-1a
                     <712>SCYA4     J04130     SCYA4    Human activation (Act-2) mRNA, complete cds                           1.2200439      11910.96   9762.73    1.2400547   16094.05   12978.5    1.6518294    32534.71

                     <1242>SCYA5    M21121     SCYA5                                                                           1
                                                        Human T cell-specific protein (RANTES) mRNA, Small inducible cytokine A5 .1720431    52082.94   44437.74   1.0835688     53220    49115.48   1.4713882    24021.56
                                                        Homo sapiens mRNA for monocyte chemotactic protein-3 (MCP-3), Small
                     <618>SCYA7     X72308     SCYA7                                                                        1.5114192        5195.08    3437.22    1.3499054   2119.23    1569.91    1.2977699    3941.34
                                                                   inducible cytokine A7 (monocyte chemotactic protein 3)
                     <280>SCYA8     Y10802     SCYA8    H.sapiens mRNA for monocyte chemotactic protein 2                     0.66002464      128.85     195.22 0.28580683       44.12     154.37
                                                        Human mRNA for gamma-interferon inducible early response gene (with
                     <315>SCYB10    X02530     SCYB10                                                                         1.0186477      5164.34     5069.8 0.82391065     6919.63    8398.52    0.9300822    15805.23
                                                                homology to platelet proteins).
                                                           Homo sapiens interferon stimulated T-cell alpha chemoattractant precursor,
                     <149>SCYB11     AF030514    SCYB11                                                                             0.79085165         443.13      560.32    1.1297667     755.78     668.97 0.87755454       450.87
                                                                       mRNA, complete cds




                                                                                                                                                                                                                                        UNCORRECTED PROOF
                                                           Homo sapiens CXC chemokine BRAK mRNA,Small inducible cytokine subfamily
                     <930>SCYB14     AF073957    SCYB14                                                                              1.1457775         102.57       89.52     0.967596      79.13      81.78
                                                                      B (Cys-X-Cys), member 14
                                                           H.sapiens ENA-78 mRNA; Small inducible cytokine subfamily B (Cys-X-Cys),
                     <364>SCYB5      X78686      SCYB5                                                                               0.7351562       24764.17     33685.59   0.5238737    17938.29   34241.63   0.5177408    24633.77
                                                                        member 5 (epithelial-derived neutrophil-activating peptide 78)

                     <1216>SCYC2     NM_003175   SCYC2                                                                           1.2883505
                                                           Homo sapiens small inducible cytokine subfamily C, member 2 (SCYC2), mRNA.                  352.57      273.66                                       1.0565346     513.18

                     <778>SCYD1      U84487      SCYD1                                                                           1.048142
                                                           Human CX3C chemokine precursor, mRNA, alternatively spliced, complete cds                  2185.25     2084.88 0.88745683        950.2     1070.7    0.8651865    1903.22
www.molmed.org




                                                           Human endothelial-monocyte activating polypeptide II mRNA; small inducible
                     <643>SCYE1      U10117      SCYE1                                                                             1.4936521          1008.26      675.03    0.9304977    1227.68    1319.38     1.533232    2409.52
                                                                    cytokine subfamily E, member 1 (endothelial monocyte-activating)
                                                           Human pre-B cell stimulating factor homologue (SDF1b) mRNA, complete cds;
                     <207>SDF1       L36033      SDF1                                                                            3.3106515             115.31       34.83    1.8533555     134.22      72.42    0.8169751     354.51
                                                                      Stromal cell-derived factor 1
                     <247>SELE       M30640      SELE      selectin E (endothelial adhesion molecule 1)                                 1.3933963      747.78      536.66    1.8097055     692.52     382.67    1.2371058     956.32
                     <556>SELL       M25280      SELL      selectin L (lymphocyte adhesion molecule 1)                                  0.8167299    64923.16     79491.59   0.8838909    56828.47   64293.53 0.78442913     50105.38
                     <435>SELP       M25322      SELP      selectin P (granule membrane protein 140kD, antigen CD62)                  0.82025766       570.44      695.44    1.8374045      48.14       26.2    1.1029831     475.11
                     <1128>SELPLG    U02297      SELPLG    selectin P ligand                                                          0.83376133      1237.01     1483.65    0.6432162     2602.8    4046.54    0.9442379    9434.57
                     <1306>SGK       NM_005627   SGK       Homo sapiens serum/glucocorticoid regulated kinase                         0.79627115     15389.15     19326.52   0.5762804    19801.29   34360.51   0.5213951    22178.86
                     <1376>SGK2      NM_016276   SGK2      Homo sapiens serum/glucocorticoid regulated kinase 2                       0.87675464      3845.63     4386.21 0.96144617      12840.69   13355.6    1.1542343    21578.34
                                                           H.sapiens SHC mRNA, Src homology 2 domain-containing transforming protein
                     <614>SHC1       X68148      SHC1                                                                            0.835677              5969.4     7143.19 0.81780505      9960.53    12179.59   0.9055248    14492.58
                                                                      1
                     <1667>SKD1      AF195514    SKD1      suppressor of K+ transport defect 1                                          0.9002648    13092.19     14542.6 0.47145957       5412.7    11480.73   0.6672447    24817.34
                     <329>SKIL       X15219      SKIL      Human sno oncogene mRNA for snoN protein, ski-related                      0.76584053      2406.11     3141.79 0.84828055      2647.56    3121.09    0.7384143    2732.79
                                                           Homo sapiens solute carrier family 12 (sodium/potassium/chloride transporters),
                     <1283>SLC12A2   NM_001046   SLC12A2                                                                             1.4108399        1132.58      802.77    1.1355375     982.24       865     0.9858086    2445.87
                                                                        member 2; NKCC1; BSC2
                     <1308>SLC1A1    U08989      SLC1A1    Human glutamate transporter mRNA; HEACC1                                     0.7328279      327.64      447.09    1.1357511      332.9     293.11    0.13212991     16.03
                     <1385>SLC1A2    U01824      SLC1A2    Human glutamate/aspartate transporter II mRNA                                 0.315216       24.88       78.93
                                                           Homo sapiens solute carrier family 1 (glial high affinity glutamate transporter),
                     <1300>SLC1A3    NM_004172   SLC1A3                                                                                  1.1147444     245.79      220.49    1.1978692     544.18     454.29    1.3401525    1283.96
                                                                       member 3 (SLC1A3), nuclear gene encoding mitochondrial protein
                                                           Homo sapiens solute carrier family 1 (glutamate/neutral amino acid transporter),
                     <1429>SLC1A4    NM_003038   SLC1A4                 member 4; ASCT1; SATT
                                                           Homo sapiens solute carrier family 1 (high affinity aspartate/glutamate transporter),
                     <1438>SLC1A6    NM_005071   SLC1A6                                                                                                                      0.85701424     95.18     111.06    1.0669813     106.25
                                                                         member 6
                     <1645>SLC21A2   U70867      SLC21A2   solute carrier family 21 (prostaglandin transporter), member 2               1.2676646       454.8      358.77    1.0772377     848.12     787.31    1.6487447    2529.57
Molecular Medicine




                                                           Human insulin-responsive glucose transporter (GLUT4) mRNA; Solute carrier
                     <768>SLC2A4     M20747      SLC2A4                                                                           0.9218729           1339.97     1453.53    0.7057859     447.56     634.13    1.0269636    2375.87
                                                                        family 2 (facilitated glucose transporter), member 4
                     <98>SLC35A1     D87969      SLC35A1   solute carrier family 35 (CMP-sialic acid transporter), member 1             1.5939733     1561.52      979.64    1.3150457    3798.47    2888.47    1.6828119    6392.75
                     <1703>SLC38A2   AF259799    SLC38A2   amino acid transporter 2                                                      0.674379    10995.79     16305.06 0.57191557     4075.11    7125.37 0.68031347      11789.9
                                                           Homo sapiens solute carrier family 3 (cystine, dibasic and neutral amino acid
                     <1367>SLC3A1    NM_000341   SLC3A1                                                                               1.0951188         1161.68
                                                                       transporters, activator of cystine, dibasic and neutral amino acid transport), member      1060.78    0.7388219    1091.24      1477     0.60735536    632.67
                                                                                         1

                     <1315>SLC5A3    NM_006933   SLC5A3                                                                               1
                                                           Homo sapiens solute carrier family 5 (inositol transporters), member 3; SMIT .4893454       900.22      604.44    1.0528213     508.06     482.57    1.0318006     731.98

                     <1536>SLC6A11   S75989      SLC6A11   solute carrier family 6 (neurotransmitter transporter, GABA), member 11      0.9687116      1711.2     1766.47 0.83058983       769.99     927.04    1.1449938    3401.33
                     <1405>SLC6A12   U27699      SLC6A12   Human pephBGT-1 betaine-GABA transporter mRNA; BGT1                          1.1640565      423.67      363.96 0.90073186        537.8     597.07    15.448186     302.63
                     <1498>SLC6A13   U76343      SLC6A13   solute carrier family 6 (neurotransmitter transporter, GABA), member 13      1.2086742     3595.83     2975.02     2.112519    4476.47    2119.02    1.7283188    7025.08

                     <1373>SLC6A14   NM_007231   SLC6A14                                                                             0.6930052
                                                           Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 14              157.43      227.17    0.6249283     108.95     174.34
                                                           Homo sapiens solute carrier family 6 (neurotransmitter transporter, noradrenalin),
                     <1431>SLC6A2    NM_001043   SLC6A2                                                                              0.49961337        730.11     1461.35    1.2036777    2105.81    1749.48    2.9411764       498
                                                                        member 2 (SLC6A2)

                     <1577>SLC6A3    NM_001044   SLC6A3    solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 1.5754126      13609.28     8638.55    1.6842669    14830.07   8805.06    1.8344827    31117.63
                     <1579>SLC6A4    NM_001045   SLC6A4    solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 1.2458595    8468.48      6797.3    1.2494153   11999.36   9603.98    1.042434    15191.13




                                                                                                                                                                                                                                    UNCORRECTED PROOF
                                                           Homo sapiens solute carrier family 6 (neurotransmitter transporter, taurine), member
                     <1284>SLC6A6    NM_003043   SLC6A6                                                                                 0.6754223   4214.73     6240.14 0.26453236     1473.44    5569.98    0.6707165   8556.86
                                                                         6; TAUT
                                                           Homo sapiens solute carrier family 7 (cationic amino acid transporter, y+ system),
                     <1344>SLC7A1    NM_003045   SLC7A1                                                                                 1.7591399    371.46      211.16    1.4491246      557      384.37 0.49418056      189.37
                                                                         member 1
                                                           Homo sapiens solute carrier family 7, (cationic amino acid transporter, y+ system)
                     <1329>SLC7A10   NM_019849   SLC7A10                                                                                1.5706061    103.66         66     1.8008124    336.95     187.11    1.3420333    637.09
                                                                         member 10

                     <1605>SLC7A11   AF252872    SLC7A11                                                                                1.493749
                                                           solute carrier family 7, (cationic amino acid transporter, y+ system) member 11           389.51      260.76    0.9612412    563.47     586.19 0.71720064      463.62
www.molmed.org




                                                           Homo sapiens solute carrier family 7 (cationic amino acid transporter, y+ system),
                     <1285>SLC7A2    NM_003046   SLC7A2                                                                                1.5160872     6953.2     4586.28    2.0981324   7155.47     3410.4    1.9210603   17302.03
                                                                         member 2
                     <1394>SLC7A5    AF104032    SLC7A5    Homo sapiens L-type amino acid transporter subunit LAT1 mRNA             0.4198193        249.02      593.16    4.340206    1401.93     323.01    0.6122344     833.3
                                                           Homo sapiens solute carrier family 7 (cationic amino acid transporter, y+ system),
                     <1286>SLC7A7    NM_003982   SLC7A7                                                                               0.93888915    27227.11    28999.28   1.0812188   56358.45   52124.92   1.4364477   84178.76
                                                                          member 7
                                                           Homo sapiens solute carrier family 7 (cationic amino acid transporter, y+ system),
                     <1322>SLC7A8    NM_012244   SLC7A8                                                                                0.6643586     592.96      892.53    0.5097801    273.13     535.78    0.7006028    760.14
                                                                          member 8
                                                           Homo sapiens solute carrier family 7 (cationic amino acid transporter, y+ system),
                     <1374>SLC7A9    NM_014270   SLC7A9                                                                                1.4503763     246.68      170.08 0.93588626      988.09    1055.78    1.2825298   1293.97
                                                                          member 9
                                                           SWI/SNF related, matrix associated, actin dependent regulator of chromatin,
                     <383>SMARCA3    Z46606      SMARCA3                                                                               1.5899826    6494.03     4084.34    1.0236284   5308.25    5185.72    1.1467565   13917.92
                                                                       subfamily a, member 3
                     <1512>SN2       AF276889    SN2       similar to N system amino acids transporter NAT-1 (M. musculus)          0.9001268       1767.39     1963.49    1.1052465   1822.01    1648.51    1.3725903   2595.28
                                                           Homo sapiens superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1
                     <1384>SOD1      NM_000454   SOD1                                                                               1.7093523          705.33
                                                                       (adult)) (SOD1); Superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1         412.63    1.7069584   4108.99     2407.2    1.619495    66118.81
                                                                                       (adult))
                                                           Human mRNA for manganese superoxide dismutase; Superoxide dismutase 2,
                     <1337>SOD2      X07834      SOD2                                                                               1.0387584 23289.11          22420.14   0.558113    64102.12   114855.1 0.54729956    34958.74
                                                                     mitochondrial
                                                           Human extracellular-superoxide dismutase (SOD3) mRNA; Superoxide
                     <1414>SOD3      J02947      SOD3                                                                               1.7590482          263.91    150.03    2.6244268    360.57     137.39 0.22154057       42.25
                                                                     dismutase 3, extracellular
                                                           Human guanine nucleotide exchange factor mRNA, complete cds, SOS1, Sons
                     <147>SOS1       L13858      SOS1                                                                              0.72687024          712.58    980.34 0.24922232      423.01    1697.32 0.21784839      262.76
                                                                      of Sevenless
                     <230>SP100      M60618      SP100     Human nuclear autoantigen (SP-100) mRNA                                 0.65864855       16815.39    25530.14   1.0873704   27703.6    25477.61   0.7804976   31954.79
                     <1450>SPC       AY026949    SPC       Stresscopin                                                              0.8169746       1873.38     2293.07    1.843361    5273.34    2860.72    1.4241024   5768.17
                     <913>SPIB       X66079      SPIB      H.sapiens Spi-B mRNA; Spi-B transcription factor (Spi-1/PU.1 related)      1.049556      2763.46     2632.98    1.1999234   6199.86    5166.88    1.1434296   8894.11
                                                           Homo sapiens secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early
                     <1370>SPP1      NM_000582   SPP1                                                                               1.3406066        430.08      320.81    0.7138064    944.53    1323.23    0.2863926    992.84
                                                                      T-lymphocyte activation 1) (SPP1)
                     <725>SPTAN1     U83867      SPTAN1    Human alpha II spectrin mRNA, Fodrin                                     0.7180892        952.61     1326.59    0.986721    2137.06    2165.82    0.6505553   4226.84
                                                           Human serum response factor (SRF) mRNA; Serum response factor (c-fos serum
                     <876>SRF        J03161      SRF                                                                            0.6461285           8005.37     12389.75   0.9466826   13178.19   13920.39   0.783101    9522.54
                                                                        response element-binding transcription factor)
                     <1490>SST       NM_001048   SST       somatostatin                                                             1.3663824         692.1      506.52    1.2026234    801.32     666.31    0.3890363    224.33
Molecular Medicine




                     <1479>SSTR1     NM_001049   SSTR1     somatostatin receptor 1                                                  0.9979184        421.88      422.76    2.1403875    643.85     300.81    0.845889     356.17
                     <1447>SSTR3     NM_001051   SSTR3     somatostatin receptor 3                                                 0.96512604        860.13      891.21 0.88508433      370.93     419.09    0.7521686    1025.8
                     <1448>SSTR5     NM_001053   SSTR5     somatostatin receptor 5                                                  0.9893724       6796.86     6869.87 0.75423396     4094.94    5429.27    1.0005215   5390.43
                     <1449>SSTRIP    NM_016148   SSTRIP    somatostatin receptor-interacting protein                                1.1929504       1251.56     1049.13    1.1102163    940.12     846.79    1.463627     626.93

                     <339>ST13       U17714      ST13                                                                          1.3992246
                                                           Homo sapiens putative tumor suppressor ST13 (ST13) mRNA, complete cds                    10392.35    7427.22    1.0396882   22095.88   21252.41 0.81154025    15350.26
                                                           Human SNC19 mRNA sequence Suppression of tumorigenicity 14 (colon
                     <31>ST14        U20428      ST14                                                                        0.8455951              5571.44     6588.78    1.0086993   7314.23    7251.15    1.1814922   7367.75
                                                                   carcinoma, matriptase, epithin)
                     <134>ST1B2      D89479      ST1B2     Homo sapiens mRNA for ST1B2                                              1.0827929       6804.65     6284.35 0.87402606     5903.95    6754.89    1.1415895   8747.11
                                                           Homo sapiens mRNA for stac, (src homology three (SH3) and cysteine rich
                     <100>STAC       D86640      STAC                                                                              1.1739846         548.11      466.88    1.189713    1361.46    1144.36    1.0978993   1790.07
                                                                       domain)
                     <290>STAT1      M97935      STAT1     Homo sapiens transcription factor ISGF-3 mRNA, complete cds                0.260532      23090.34    88627.66 0.42485854      22073    51953.76 0.51435715    17074.81
                                                           Homo sapiens interferon alpha induced transcriptional activator (ISGF-3) mRNA
                     <1>STAT2        M97934      STAT2                                                                                                                     0.7004029    219.03     312.72 0.48435143      279.34
                                                                      sequence
                     <959>STAT3      L29277      STAT3     Homo sapiens DNA-binding protein (APRF) mRNA, complete cds              0.50296307       2648.88     5266.55 0.39669874     4340.17    10940.72   0.5028752   8561.31
                     <520>STAT4      L78440      STAT4     Homo sapiens STAT4 mRNA, complete cds                                  1.3629283       1959.7    1437.86    0.7165255    3333.52    4652.34    1.1076419   2746.11




                                                                                                                                                                                                                                 UNCORRECTED PROOF
                     <1013>STAT5     L41142      STAT5                                                                              0.6383952
                                                           Homo sapiens signal transducer and activator of transcription (STAT5) mRNA            1587.44    2486.61    0.5952967    2671.37    4487.46 0.76900154     7885.48
                                                           Human signal transducer and activator of transcription Stat5B mRNA, complete
                     <44>STAT5B      U47686      STAT5B                                                                            1.0673211     12492.93   11704.94   1.4490699    15166.82   10466.59   1.1246285   13229.59
                                                                        cds
                     <986>STAT6      U16031      STAT6     Human transcription factor IL-4 Stat mRNA, complete cds                 0.564676      4120.35    7296.84 0.57754123      4054.38    7020.07 0.84464794     6889.92
                                                           Human microsomal stress 70 protein ATPase core (stch) mRNA; Stress 70 protein
                     <361>STCH       U04735      STCH                                                                             1.054906       1171.22    1110.26    0.42323235    641.98    1516.85 0.73315704      670.89
                                                                        chaperone, microsome-associated, 60kD
www.molmed.org



                     <366>STE        U08098      STE       Human estrogen sulfotransferase (STE) mRNA                              1.532601       193.92     126.53     1.434637     205.44      143.2    1.991767       62.9
                                                           Homo sapiens stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
                     <1313>STIP1     NM_006819   STIP1                                                                           0.5683907        2074.2    3649.25    0.7853971    2812.24    3580.66    0.8671067   5211.71
                                                                     protein)
                                                           Human Ste20-like kinase (MST2) mRNA; Serine/threonine kinase 3 (Ste20, yeast
                     <1331>STK3      U26424      STK3                                                                          0.77992207         182.26     233.69    0.8764858     584.73     667.13    0.6698743    385.66
                                                                        homolog)
                                                           Human stress responsive serine/threonine protein kinase Krs-2 mRNA,
                     <519>STK4       U60207      STK4                                                                            1.4555148       9106.37    6256.46    0.5554361    5087.65    9159.74    0.8532169   7191.27
                                                                      Serine/threonine kinase 4
                     <1027>STK9      X89059      STK9      serine/threonine kinase 9                                              0.8780312       353.39     402.48    2.1589608      867.6     401.86 0.94204634     4972.13
                                                           Homo sapiens sulfotransferase family 1A, phenol-preferring, member 1
                     <1217>SULT1A1   NM_001055   SULT1A1                                                                          0.7395209      2531.55    3423.23    1.7847915    13209.01   7400.87    1.7413932   63278.21
                                                                     (SULT1A1)
                                                           Homo sapiens sulfotransferase family 1A, phenol-preferring, member 2
                     <1130>SULT1A2   NM_001054   SULT1A2                                                                           0.654059       561.32     858.21    1.0196402     943.83     925.65    1.400566    2454.52
                                                                     (SULT1A2) mRNA

                     <1219>SULT1A3   U08032      SULT1A3   Human thermolabile (monoamine, M form) phenol sulfotransferase (STM) 0.50233245
                                                                                                                                mRNA              290.75      578.8    1.3304601     3358.6    2524.39    1.7172954   14789.52

                     <283>SULT1C1    U66036      SULT1C1   Human sulfotransferase mRNA family 1C, member 1 (SULT1C1)              0.6630624      23362.09   35233.62 0.51313764     15938.25   31060.38   0.9799273   41880.1
                     <593>SULT2A1    X70222      SULT2A1   H.sapiens mRNA for dehydroepiandrosterone sulphotransferase            0.7107088       321.88      452.9    0.6389596     163.12     255.29 0.92272705     1188.98

                     <1089>SULT2B1   U92314      SULT2B1   Homo sapiens hydroxysteroid sulfotransferase SULT2B1a (HSST2) mRNA0.22243485            15.11      67.93                                       1.5511208    271.26

                     <662>SULTX3     AF188698    SULTX3    Homo sapiens sulfotransferase-like protein mRNA                        0.8568963       327.72     382.45
                     <218>SURB7      U52960      SURB7     SRB7 (suppressor of RNA polymerase B, yeast) homolog                   1.3368633      1413.88    1057.61    0.7925929    1448.21    1827.18    1.0511346   1835.26

                     <962>SYK        L28824      SYK                                                                             0.72280633
                                                           Homo sapiens protein tyrosine kinase (Syk) mRNA; Spleen tyrosine kinase               8791.11    12162.47   1.0204377    56237.7    55111.35   0.9168397   47320.16

                     <1047>TAB1      U49928      TAB1      Homo sapiens TAK1 binding protein (TAB1) mRNA, complete cds            1.1769663       738.77     627.69    1.4465773     718.92     496.98    1.0171915   1641.32

                     <389>TAF1A      L39060      TAF1A                                                                              1.3758335
                                                           TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kD            897.47     652.31     1.011788    1196.49    1182.55 0.93723047     1030.11

                     <390>TAF1B      L39061      TAF1B                                                                              0.9951207
                                                           TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kD           1654.01    1662.12    0.9468532    3591.49    3793.08    0.7626809   3951.32

                     <1000>TAF1C     L39059      TAF1C                                                                              1.1783875
                                                           TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kD          5334.56      4527      1.377624    6736.43    4889.89    1.4414697   8103.38

                     <504>TAF2A      D90359      TAF2A     Human CCG1 mRNA                                                        0.9935102       2642.3    2659.56 0.66004914      2811.73    4259.88 0.79189515     3330.64
Molecular Medicine




                     <136>TAF2B      AF040701    TAF2B                                                                               1.1189829
                                                           TATA box binding protein (TBP)-associated factor, RNA polymerase II, B, 150kD         2649.83    2368.07    1.1488264    14034.27   12216.18   1.4726523   17426.69

                     <453>TAF2C1     Y11354      TAF2C1                                                                             1.1358454
                                                           TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kD         705.36       621     0.85257024   1249.22    1465.24    0.7717549   1785.37

                     <225>TAF2C2     Y09321      TAF2C2    TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 1.3689789
                                                                                                                                    105kD         457.28     334.03 0.72276783       641.76     887.92    1.0118834    876.21

                     <568>TAF2D      U80191      TAF2D                                                                              0.9068754
                                                           TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100kD         1720.27    1896.92    0.7438821    2018.42    2713.36    0.589938    1923.77

                     <676>TAF2E      U31659      TAF2E                                                                               0.8497626
                                                           TATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85kD        275.68     324.42 0.79619354       631.27     792.86    0.5452263    592.83

                     <391>TAF2F      U18062      TAF2F                                                                               2.5096254
                                                           TATA box binding protein (TBP)-associated factor, RNA polymerase II, F, 55kD          17906.58   7135.16    0.9181209    59027.93   64292.11   1.1786829   75288.33

                     <404>TAF2G      U21858      TAF2G                                                                              1.5006304
                                                           TATA box binding protein (TBP)-associated factor, RNA polymerase II, G, 32kD          1547.54    1031.26    1.5231419    1124.49     738.27    1.2719935   3942.76

                     <987>TAF2H      U13991      TAF2H                                                                              1.2453852
                                                           TATA box binding protein (TBP)-associated factor, RNA polymerase II, H, 30kD          8015.05     6435.8     1.974966    17806.55   9016.13    1.4878892   19639.08

                     <462>TAF2I      D63705      TAF2I                                                                               1.1445976
                                                           TATA box binding protein (TBP)-associated factor, RNA polymerase II, I, 28kD          2578.08    2252.39    0.9614754    1928.71    2005.99    1.239706    6982.52

                     <211>TAF2J      U57693      TAF2J                                                                               1.7699783
                                                           TATA box binding protein (TBP)-associated factor, RNA polymerase II, J, 20kD           6052.6    3419.59     1.068331    7945.37    7437.18    0.8452574   34234.16
                                                         TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD
                     <422>TAF2N     U51334      TAF2N                                                                             0.9667369         1408.41    1456.87 0.46282873      1352.33    2921.88    0.7235525   2238.44
                                                                      (RNA-binding protein 56)




                                                                                                                                                                                                                                    UNCORRECTED PROOF
                     <223>TANK      U63830      TANK                                                                       1.1847651
                                                         Human TRAF family member-associated NF-kB activator TANK mRNA, I-TRAF                      7770.72    6558.87 0.52814037      7601.82    14393.56   0.7706162   18726.29

                     <651>TCEB1     L34587      TCEB1    transcription elongation factor B (SIII), polypeptide 1 (15kD, elongin C)    1.384927      2899.04    2093.28    1.2541422    14421.28   11498.92   1.2936739   31423.17
                     <406>TCEB1L    Z47087      TCEB1L   transcription elongation factor B (SIII), polypeptide 1-like                1.0508937     32596.62      31018    1.5459238    56060.47   36263.41   1.3701257   75419.61
                     <1166>TCEB2    L42856      TCEB2    Transcription elongation factor B (SIII), polypeptide 2 (18kD, elongin B)   1.2650614       402.96     318.53     2.622494    2457.88     937.23    1.3066322   3625.12
                                                                                                                                     0.4761658        64.33      135.1    0.82398933    228.69     277.54
www.molmed.org



                     <1072>TCF1     M57732      TCF1     Human hepatic nuclear factor 1 (TCF1) mRNA

                     <289>TCF12     M83233      TCF12    Homo sapiens transcription factor (HTF4) mRNA, complete cds                 0.7137881       745.93    1045.03 0.44084057      1553.91    3524.88    0.7461042   2072.67
                     <965>TCF15     U08336      TCF15    Human basic helix-loop-helix transcription factor mRNA, complete cds        1.1068629      1824.42    1648.28    1.0893334     2099.2    1927.05    0.9565763   2750.75
                     <142>TCF17     D89928      TCF17    Homo sapiens HKL1 mRNA, complete cds                                        1.4499542      1660.27    1145.05    0.7219274    3851.23    5334.65    0.8795749   6028.51
                     <1151>TCF19    NM_007109   TCF19    Homo sapiens transcription factor 19 (SC1) (TCF19), mRNA                    1.0568367      2676.27    2532.34    0.8666213    5280.09    6092.73 0.99677336     6895.06
                     <626>TCF2      X58840      TCF2     Human mRNA for variant hepatic nuclear factor 1 (vHNF1), TCF2               0.7910744        227.6     287.71                                       2.4132793     95.59
                     <837>TCF20     U19345      TCF20    Homo sapiens AR1 (TCF20) mRNA, partial cds                                   1.335192        718.4     538.05    1.0946509     210.37     192.18 0.78070897      335.01
                     <587>TCF21     AF047419    TCF21    Homo sapiens epicardin mRNA, complete cds.                                  1.0204946     31707.06    31070.29   0.5242474    45599.05   86980.02   0.7985968   51010.34
                     <607>TCF3      M31523      TCF3     Human transcription factor (E2A) mRNA, complete cds                         1.0286857      7490.21    7281.34    1.8734461    17963.95   9588.72    1.1910044   30232.17
                     <950>TCF4      NM_003199   TCF4     Homo sapiens transcription factor 4 (TCF4)                                    1.00232      3326.54    3318.84     3.054224    11644.9    3812.72    1.0187585   3317.74
                     <272>TCF6L1    M62810      TCF6L1   Human mitochondrial transcription factor 1 mRNA                             1.6564704      2747.72    1658.78    0.9574705     2113.3    2207.17    1.5357175   2993.39

                     <1245>TCF7     NM_003202   TCF7                                                                              0.878291
                                                         Homo sapiens transcription factor 7 (T-cell specific, HMG-box) (TCF7) mRNA.               16689.32    19002.04   1.3727424    34088.94   24832.73   0.953684    18024.6

                     <1209>TCF7L2   Y11306      TCF7L2   Homo sapiens mRNA for hTCF-4                                                0.79085183     3402.64     4302.5    1.0459572       5414    5176.12    0.9642978   9389.85
                                                         Human mRNA for transcription factor AREB6; Transcription factor 8 (represses
                     <182>TCF8      D15050      TCF8                                                                              1.0148778         1813.13    1786.55    1.0671958    3669.35    3438.31    0.8253281   2854.48
                                                                      interleukin 2 expression)
                                                         Human YL-1 mRNA for YL-1 protein (nuclear protein with DNA-binding ability),
                     <1020>TCFL1    D43642      TCFL1                                                                            0.85458446         1319.94    1544.54    1.2100602    2761.66    2282.25    1.2523497   15488.61
                                                                    complete cds

                     <173>TCFL5     AB012124    TCFL5    Homo sapiens TCFL5 mRNA for transcription factor-like 5, complete cds       0.9901858      1463.96    1478.47 0.39842793       283.86     712.45    0.593406    2341.77

                     <1218>TDGF1    NM_003212   TDGF1    Homo sapiens teratocarcinoma-derived growth factor 1 (TDGF1) mRNA

                     <15>TERF1      NM_003218   TERF1    Homo sapiens telomeric repeat binding factor (NIMA-interacting) 1           0.79823905     3005.45     3765.1    1.1657951    1237.27    1061.31 0.89699453      998.31
                     <56>TERT       NM_003219   TERT     Homo sapiens telomerase reverse transcriptase                               3.1614647     133653.92   42275.95   1.5259928    98111.46   64293.53   1.4899031   85849.17
                                                         Human transcription factor ERF-1 mRNA; Transcription factor AP-2 gamma
                     <282>TFAP2C    U85658      TFAP2C                                                                          0.6180641             70.62     114.26    0.60529673     99.65     164.63
                                                                     (activating enhancer-binding protein 2 gamma)

                     <931>TFDP1     L23959      TFDP1                                                                           1
                                                         Homo sapiens E2F-related transcription factor (DP-1) mRNA, complete cds. .0603232           789.75     744.82    0.7789009    2182.13    2801.55    0.6014391   3154.44
Molecular Medicine




                                                         Human DP2 (Humdp2) mRNA; Transcription factor Dp-2 (E2F dimerization
                     <656>TFDP2     U18422      TFDP2                                                                         2.6920784             2557.69     950.08    1.8142351    1481.45     816.57    1.2429729   3068.03
                                                                   partner 2)

                     <40>TFE3       NM_006521   TFE3                                                                            1.0924324
                                                         Homo sapiens transcription factor binding to IGHM enhancer 3 (TFE3), mRNA.                 9164.36    8388.95 0.96019965      8899.14    9268.01    1.0046841   10466.89

                     <1204>TGFA     X70340      TGFA     H.sapiens mRNA for transforming growth factor alpha                          0.501737       274.41     546.92
                     <12>TGFB1      X02812      TGFB1    Human transforming growth factor-beta (TGF-beta; TGFB)                      0.69179595       607.3     877.86    0.6796793    4337.19    6381.23 0.85917836     18293.61
                                                         Human transforming growth factor-beta-2 mRNA; glioblastoma -derived T-cell
                     <316>TGFB2     M19154      TGFB2                                                                               0.8857621         492.9     556.47
                                                                     suppressor factor (G-TSF); bsc-1 cell growth inhibitor; polyergin; cetermin

                     <91>TGFB3      J03241      TGFB3                                                                         1.0676686
                                                         Human transforming growth factor-beta 3 (TGF-beta3) mRNA, complete cds.                    3703.71    3468.97    1.2487533    1399.89    1121.03 0.021246295      14.47

                     <177>TGFBR1    L11695      TGFBR1   Human activin receptor-like kinase (ALK-5) mRNA, complete cds               0.84397537     1197.39    1418.75    1.6261094     5299.1    3258.76    1.5803334   4598.96
                     <102>TGFBR2    D50683      TGFBR2   Homo sapiens mRNA for TGF-betaIIR alpha, complete cds                       0.8408032      8020.38    9538.95 0.50328976      9899.11    19668.81 0.79223955    23261.38
                                                         Human transforming growth factor-beta type III receptor (TGF-beta) mRNA,
                     <192>TGFBR3    L07594      TGFBR3                                                                            1.738978           1687.4     970.34    0.7378809    2248.67    3047.47    1.061375    11490.85
                                                                     complete cds
                     <1430>TH       NM_000360   TH       Homo sapiens tyrosine hydroxylase (TH), mRNA                                0.9808583       114.27      116.5    1.1735457     205.57     175.17    1.816887     710.53
                     <1601>TH1L       AJ238374    TH1L         TH1-like (Drosophila homolog)                                        1.0723598      7829.17    7300.88    1.3084778    14098.77   10774.94   1.2380502    23307.41




                                                                                                                                                                                                                                    UNCORRECTED PROOF
                     <645>THPO        L33410      THPO         Human c-mpl ligand (ML) mRNA, complete cds                           1.0623603       503.75     474.18    1.1330882     492.95     435.05    1.1296118     447.01
                     <1145>THRA       M24898      THRA         Human triiodothyronine recptor (THRA1, ear1) mRNA, complete cds     0.90419143      3787.26    4188.56    1.6939914    6656.98    3929.76    1.9177382    4712.42
                     <854>THRB        X04707      THRB         Human c-erb-A mRNA for thyroid hormone receptor                      1.1189482       171.49     153.26    1.1301008      47.08      41.66    0.24441221     52.27
                     <981>THY1        NM_006288   THY1         Homo sapiens Thy-1 cell surface antigen (THY1), mRNA                 1.3466197       148.99     110.64    0.17698598     21.21     119.84    1.0630825     108.36

                     <963>TIM         U02082      TIM          Human guanine nucleotide regulatory protein (tim1) mRNA, complete cds. 1.7139926    12482.46   7282.68     6.414127    80785.16   12594.88 0.78722817     47086.42
www.molmed.org



                                                               Human tissue inhibitor of metalloproteinase-3 precursor (TIMP-3) mRNA, complete
                     <956>TIMP3       U02571      TIMP3                                                                                1.3704153    192.05     140.14
                                                                             cds
                     <292>TLR1        U88540      TLR1         Homo sapiens Toll-like receptor 1 (TLR1) mRNA, complete cds         0.66002965      20674.75   31323.97 0.27665433     12590.92   45511.38 0.43506956     17675.92
                     <293>TLR2        U88878      TLR2         Homo sapiens Toll-like receptor 2 (TLR2) mRNA, complete cds          0.6175583      15500.3    25099.33   0.2648418    9542.43    36030.68   0.6830011    10776.31
                     <294>TLR3        U88879      TLR3         Homo sapiens Toll-like receptor 3 (TLR3) mRNA, complete cds         0.85377276       311.61     364.98 0.44600812        164.8      369.5
                     <295>TLR4        U88880      TLR4         Homo sapiens Toll-like receptor 4 (TLR4) mRNA, complete cds          0.5609814      6018.96    10729.34 0.24177396     4020.95    16631.03 0.50880784     4452.45
                     <574>TLR5        U88881      TLR5         Homo sapiens Toll-like receptor 5 (TLR5) mRNA, partial cds.          0.8468219      3893.56    4597.85 0.87125355      2384.29    2736.62    1.0384922    7053.47
                     <472>TNF         M10988      TNF          Human tumor necrosis factor (TNF) mRNA                              0.48433772      1077.85    2225.41 0.87335205       1868.1      2139     1.1063132     1396.3

                     <1231>TNFAIP3    M59465      TNFAIP3      Human tumor necrosis factor alpha inducible protein A20 mRNA complete 0.81522256
                                                                                                                                     cds           3411.47    4184.71    1.0417526    31482.23   30220.45   1.2717457    43983.16

                     <320>TNFAIP6     M31165      TNFAIP6      Tumor necrosis factor, alpha-induced protein 6                      0.72269946      11119.31   15385.8 0.15247032      1711.49    11225.07 0.70697635     7338.69
                                                               Homo sapiens death receptor 5 (DR5) mRNA, Tumor necrosis factor receptor
                     <830>TNFRSF10B   AF016268    TNFRSF10B                                                                        0.37885368        72.38     191.05
                                                                          superfamily, member 10b
                     <815>TNFRSF10C   AF016267    TNFRSF10C Homo sapiens TRAIL receptor 3 mRNA, complete cds                       0.6515376       15896.07   24397.78 0.25551084      5511.1    21568.95    0.630571    53662.44
                                                            Homo sapiens receptor activator of nuclear factor-kappa B (RANK) mRNA,
                     <578>TNFRSF11A   AF018253    TNFRSF11A                                                                        0.8000153       2096.96    2621.15 0.60297465       585.41     970.87    0.7799016    3132.35
                                                                        complete cds
                     <454>TNFRSF11B   U94332      TNFRSF11B    Human osteoprotegerin (OPG) mRNA, complete cds                      0.91811883          196     213.48    1.1733834      187.8     160.05    1.0436695     434.25
                                                               Human Apo-3 mRNA; Tumor necrosis factor receptor superfamily, member 12
                     <45>TNFRSF12     U74611      TNFRSF12                                                                          0.6671052       968.53    1451.84     1.130148     3571.2    3159.94    1.1897811    2446.19
                                                                           (translocating chain-association membrane protein)
                                                               Homo sapiens tumor necrosis factor receptor superfamily, member 17
                     <633>TNFRSF17    NM_001192   TNFRSF17                                                                          0.8695109          557     640.59    1.7734711     844.19     476.01     1.347977    2099.38
                                                                          (TNFRSF17), mRNA
                     <917>TNFRSF1A    X55313      TNFRSF1A     H.sapiens TNF-R mRNA for tumor necrosis factor receptor type 1.      0.7218649      3112.58    4311.86 0.60209566      6094.34    10121.88   0.7949344    6019.76
                     <1185>TNFRSF1B   M32315      TNFRSF1B     Human tumor necrosis factor receptor mRNA, TNF R2                     0.682496      2056.77     3013.6    0.5732391    4866.76    8489.93 0.84942347      11741.14
                     <957>TNFRSF4     X75962      TNFRSF4      H.sapiens mRNA for OX40 homologue                                    1.0712456      4771.51    4454.17    1.1203399    9642.25    8606.54    1.1709824    18546.99
                                                               Human CDw40 mRNA for nerve growth factor receptor-related B-lymphocyte
                     <843>TNFRSF5     X60592      TNFRSF5                                                                           1.2171453      1198.17     984.41     2.452248    3500.29    1427.38    1.4551802    1679.86
                                                                        activation molecule; CD40
                     <297>TNFRSF6     X63717      TNFRSF6      H.sapiens mRNA for APO-1 cell surface antigen, FAS                   1.1526153      8730.15    7574.21    0.4635324    3946.26    8513.45    0.7376652    5442.56
Molecular Medicine




                     <490>TNFRSF9     L12964      TNFRSF9      Human activation dependent T cell mRNA, complete cds                0.93828946         5805    6186.79    1.2387437    6718.76    5423.85    1.3579752     4001.6

                     <203>TNFSF10     U37518      TNFSF10      Human TNF-related apoptosis inducing ligand TRAIL mRNA, complete cds 1.0360405      14828.61   14312.77 0.92205226     29642.95   32148.88 0.77134174     49269.42

                     <144>TNFSF11     AF053712    TNFSF11      Homo sapiens osteoprotegerin ligand mRNA, complete cds               1.3840233       204.96     148.09    0.4480317      185.4     413.81    0.6696388     253.09
                     <114>TNFSF4      D90224      TNFSF4       Human mRNA for glycoprotein 34 (gp34).                               1.0471736      1184.06    1130.72 0.46445552      1360.85    2929.99    0.3928231    2463.81
                                                               Human CD40-ligand mRNA (Tumor necrosis factor (ligand) superfamily, member
                     <535>TNFSF5      L07414      TNFSF5                                                                             2.1785476     2066.81     948.71    0.8315093    1571.22     1889.6    0.7587201    2541.94
                                                                         5); CD40L
                     <187>TNFSF6      D38122      TNFSF6       Human mRNA for Fas ligand, complete cds; FasL                        0.6594189      2347.03    3559.24 0.70237005      3416.11    4863.69 0.93371034      4859.99
                     <610>TNFSF8      L09753      TNFSF8       Homo sapiens CD30 ligand mRNA, complete cds.                          1.017844       193.37     189.98    1.3271011     271.14     204.31    0.7453956      50.59
                     <41>TNFSF9       U03398      TNFSF9       Human receptor 4-1BB ligand mRNA, complete cds                       1.2190312      54551.45   44749.84   1.8587763    89834.68   48330.01    1.960417    61298.69
                     <619>TNKS        AF082556    TNKS         tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase    1.9084308       168.19      88.13      1.29723     395.72     305.05    1.0149434     578.67
                     <158>TOP1        J03250      TOP1         Human topoisomerase I mRNA, complete cds                             0.4917702       821.63    1670.76    0.7010445    18619.54   26559.71   0.7666717    19398.19
                     <141>TOP2A       J04088      TOP2A        Human DNA topoisomerase II (top2) mRNA, complete cds                 1.1708964       835.54     713.59 0.90656465       646.29      712.9    0.8420091    1958.21
                                                               H.sapiens TOP2 mRNA for DNA topoisomerase II (partial).; Topoisomerase (DNA)
                     <298>TOP2B       Z15115      TOP2B                                                                              1.5069188     10344.35   6864.57    1.2524788    27216.14   21729.82   1.0905285    26581.97
                                                                           II beta (180kD)
                     <928>TOP3B     AF017146    TOP3B     Homo sapiens DNA topoisomerase III beta (TOP3b) mRNA, complete cds 1.1049391             676.72     612.45    0.8536578    570.73     668.57    1.0273547     433.78




                                                                                                                                                                                                                                  UNCORRECTED PROOF
                     <166>TOPBP1    AB019397    TOPBP1                                                                          0.8712509
                                                          Homo sapiens mRNA for DNA topoisomerase II binding protein, complete cds                4677.45    5368.66    0.6377796   10151.5    15916.94   0.7645469   21891.17

                     <884>TP53      M14695      TP53      Human p53 cellular tumor antigen mRNA, complete cds                       0.821848       207.87     252.93    0.767935     558.45     727.21    0.8085441      699.9
                     <495>TP53BP1   U09477      TP53BP1   Human clone 53BP1 p53-binding protein mRNA, partial cds.                 0.9076257      3105.75    3421.84    0.9740717   6674.68    6852.35    0.7600351    7630.76
                     <518>TP53BP2   U58334      TP53BP2   Human Bcl2, p53 binding protein Bbp/53BP2 (BBP/53BP2) mRNA             0.47091165         1802     3826.62 0.61112714     2517.96    4120.19    0.5977574     1744.8
                                                                                                                                   1.4427493       422.74     293.01    0.6483404     94.93     146.42
www.molmed.org



                     <1451>TPH      X52836      TPH       tryptophan hydroxylase (tryptophan 5-monooxygenase)

                     <402>TPMT      U12387      TPMT      Human thiopurine methyltransferase (TPMT) mRNA                         0.81609803        854.12    1046.59 0.16613819       59.73     359.52 0.91886055       693.85

                     <1224>TPR      X66397      TPR                                                                              0.5237271
                                                          H.sapiens tpr mRNA; Translocated promoter region (to activated MET oncogene)             551.16    1052.38    0.6214157   2000.71     3219.6    0.6634362    2992.21

                     <589>TPST1     AF038009    TPST1     Homo sapiens tyrosylprotein sulfotransferase-1 mRNA                      0.7959644      1122.66    1410.44 0.27399808     3194.96    11660.52   0.7257909    6460.04
                     <612>TPST2     AF049891    TPST2     Homo sapiens tyrosylprotein sulfotransferase-2 mRNA                      1.0504297      21424.06   20395.52   0.8104107   53834.48   66428.64   1.4497318   47847.47
                     <1508>TR       AF201385    TR        thioredoxin reductase beta                                               1.2675604      11638.65   9181.93    1.3604861     15308    11251.86   1.3276913   24498.64
                     <1619>TR2      AF171055    TR2       thioredoxin reductase 2                                                  1.1550473       515.59     446.38    1.3478463     86.99      64.54    1.5389029     501.59
                     <478>TRA@      X02592      TRA@      Human mRNA for T-cell receptor alpha chain (TCR-alpha).                  1.0815374      42083.59   38910.9    1.3718778   80260.28   58503.96   1.0767908   43496.56

                     <1023>TRADD    L41690      TRADD                                                                          0.8501461
                                                          Homo sapiens TNF receptor-1 associated protein (TRADD) mRNA, 3' end of cds              4034.36    4745.49    1.7761345   28205.3    15880.16   1.0273334   65620.88

                     <972>TRAF1     NM_005658   TRAF1     Homo sapiens TNF receptor-associated factor 1 (TRAF1) mRNA.              0.8687446      1127.17    1297.47    1.3426664   2841.23    2116.11    1.4375027    9858.25
                                                          Human tumor necrosis factor type 2 receptor associated protein (TRAP3) mRNA,
                     <1165>TRAF2    U12597      TRAF2                                                                             0.7843242        220.85     281.58    1.2096454    766.02     633.26    1.0919924    2709.67
                                                                       complete cds
                     <634>TRAF3     NM_003300   TRAF3     Homo sapiens TNF receptor-associated factor 3 (TRAF3) mRNA.            0.86982733       1971.02    2265.99     1.16334    3254.56     2797.6    1.140438     2932.91
                     <1029>TRAF4    X80200      TRAF4     H.sapiens MLN62 mRNA (TNF receptor-associated factor 4)                  1.1122944      1120.57    1007.44 0.78602165     1247.77    1587.45    0.9372971    1994.99
                     <143>TRAF5     AB000509    TRAF5     Homo sapiens mRNA for TRAF5, complete cds                                1.3042637      4968.71    3809.59    1.2957959   14673.27   11323.75   1.3323768   11073.45

                     <527>TRAF6     U78798      TRAF6     Human TNF receptor associated factor 6 (TRAF6) mRNA, complete cds 0.73764175            2500.65    3390.06 0.66283315      1693.3    2554.64    0.7522768    4646.46
                                                          Homo sapiens heat shock protein 75 (hsp75) mRNA, partial cds (tumor necrosis
                     <831>TRAP1     AF043254    TRAP1                                                                            1.2387124        2845.88    2297.45    1.4532421   4172.49    2871.16    1.2267213    9390.27
                                                                      factor type 1 receptor associated protein )
                     <881>TRB@      M12886      TRB@      Human T-cell receptor active beta-chain mRNA, complete cds               1.3654299      2446.55    1791.78    1.3366526   8316.84    6222.14    1.2140601    8967.06
                     <13>TSC2       NM_000548   TSC2      Homo sapiens tuberous sclerosis 2 (TSC2), transcript variant 1           0.9329556       255.21     273.55    1.0650606    754.67     708.57 0.80380255       2036.9
                                                          Human putative regulatory protein TGF-beta-stimulated clone 22 homolog
                     <213>TSC22     U35048      TSC22                                                                            0.751579         9132.03    12150.46   0.3942789   6313.45    16012.65   0.6122547    9887.02
                                                                   (TSC22)
                     <1400>TSHB     NM_000549   TSHB      Homo sapiens thyroid stimulating hormone, beta (TSHB)                    1.0012366       121.46     121.31     1.13294     230.44      203.4    1.6542604     347.13
                     <1287>TSHR     NM_000369   TSHR      Homo sapiens thyroid stimulating hormone receptor (TSHR)                 1.5590934      5131.07    3291.06    1.6201597   2801.71    1729.28    1.3291074    5843.78
Molecular Medicine




                     <821>TSSC1     AF019952    TSSC1                                                                        1.588461
                                                          Homo sapiens tumor suppressing STF cDNA 1 (TSSC1) mRNA, complete cds                    23209.1    14611.06   2.8707466   69034.36   24047.53   2.4134605   154159.69

                     <659>TTF1      X83973      TTF1      transcription termination factor, RNA polymerase                         1.6262369      1354.07     832.64 0.72278446      1309.1    1811.19    0.6821387    4841.22
                     <480>TTF2      AF073771    TTF2      transcription termination factor, RNA polymerase II                      1.1262867      4704.68    4177.16 0.96844125     7618.34     7866.6    1.021636     6484.62
                     <1527>TXN      X77584      TXN       thioredoxin                                                              2.3040261      4863.73    2110.97    1.678995    15741.72   9375.68    1.6947672   86658.99
                     <1475>TXN2     U78678      TXN2      thioredoxin, mitochondrial                                               1.6459146        1232      748.52    2.2839572   1782.72     780.54    1.5197012    3204.29
                     <1656>TXNDC2   NM_032243   TXNDC2    thioredoxin domain-containing 2 (spermatozoa)                            0.7593089       3583.3    4719.16    1.0308496   4794.09    4650.62    1.0467241    7905.97
                     <1617>TXNL     BC001156    TXNL      thioredoxin-like, 32kD                                                   1.1548728      9951.62    8617.07    1.1078093   23944.8    21614.55   1.0968213   43086.86
                     <1612>TXNRD1   X91247      TXNRD1    thioredoxin reductase 1                                                0.91418123       16372.52   17909.49   0.4641998   16303.12   35120.91   0.5149352   28525.29

                     <919>TYK2      X54637      TYK2                                                                              0.9674033
                                                          Human tyk2 mRNA for non-receptor protein tyrosine kinase; Tyrosine kinase 2             7209.67     7452.6    1.1265794   11512.64   10219.11   1.1980256   14233.97

                     <219>UBL1      U61397      UBL1      ubiquitin-like 1 (sentrin)                                               1.4683061      7245.87    4934.85    1.1463096   7597.27    6627.59    1.1884894   11313.35
                     <973>UBTF      X53390      UBTF      upstream binding transcription factor, RNA polymerase I                  1.2135397       1179.5     971.95    1.0823042   2442.49    2256.75 0.87724113      7101.32
                                                          Homo sapiens ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
                     <960>UCHL1     NM_004181   UCHL1                                                                                 1.7074318    127.05      74.41    0.5805927     85.62     147.47
                                                                     (UCHL1) mRNA
                                                           Human ubiquitin carboxyl-terminal hydrolase (PGP 9.5, UCH-L3) isozyme L3
                     <608>UCHL3      M30496      UCHL3                                                                             2.534424     4137.65    1632.58    1.8538554    14400.34   7767.78    1.7473754   6982.04
                                                                      mRNA




                                                                                                                                                                                                                                UNCORRECTED PROOF
                     <1684>UFD1L     BC005087    UFD1L     Ubiquitin fusion degradation 1-like                                    1.855261      7852.93    4232.79    1.4609858    13598.14   9307.51    1.4482927   31485.97
                     <758>UGT1A1     M57899      UGT1A1    Human bilirubin UDP-glucuronosyltransferase isozyme 1 mRNA            1.6528747        68.71      41.57    0.7044187      16.42      23.31    1.4177574    244.79
                     <658>UGT1A6     J04093      UGT1A6    Homo sapiens phenol UDP-glucuronosyltransferase (UDPGT) mRNA         0.68421394      1483.54    2168.24    0.4340544      484.6    1116.45    0.6812755   1796.36
                     <418>UGT1A8     U42604      UGT1A8    Human UDP-glucuronosyltransferase (UGT1H), exon 1                    0.24770786        63.22     255.22 0.20171674         8.93      44.27
                     <473>UGT1A9     AF056188    UGT1A9    Homo sapiens UDP-glucuronosyltransferase 1A9 (UGT1A9) mRNA            0.8013247       508.12      634.1    0.38436556   1215.46    3162.25    0.7660301   1936.21
www.molmed.org




                     <655>UGT2A1     NM_006798   UGT2A1    Homo sapiens UDP glycosyltransferase 2 family, polypeptide A1 (UGT2A1) 1.5484004      262.81     169.73    0.8806923     415.22     471.47    1.118335     659.84

                     <759>UGT2B      M57951      UGT2B     Human bilirubin UDP-glucuronosyltransferase isozyme 2 mRNA            1.9139472       428.15      223.7    1.4132842     686.63     485.84    0.8495379   1096.66

                     <357>UGT2B10    NM_001075   UGT2B10                                                                          1.171105
                                                           Homo sapiens UDP glycosyltransferase 2 family, polypeptide B10 (UGT2B10)             13210.86   11280.68      0.7587    9011.11    11877.04   0.8484781   9827.48

                     <1220>UGT2B15   U08854      UGT2B15   Human UDP glucuronosyltransferase precursor (UGT2B15) mRNA

                     <870>UGT2B17    U59209      UGT2B17   Homo sapiens C19steroid specific UDP-glucuronosyltransferase mRNA 0.24690583           43.29     175.33 0.30022624        39.81      132.6

                     <333>UGT2B4     Y00317      UGT2B4    Human mRNA for liver microsomal UDP-glucuronosyltransferase (UDPGT). 0.804747         906.29    1126.18    0.7231301     918.65    1270.38    2.0485392    888.39

                     <609>UGT2B7     J05428      UGT2B7                                                                      0.81744623
                                                           Human 3,4-catechol estrogen UDP-glucuronosyltransferase mRNA, complete cds             41.42      50.67    0.8053303     267.12     331.69 0.19297768       63.81

                     <567>UGT8       U62899      UGT8      Human ceramide UDPgalactosyltransferase mRNA                          1.6706227       434.98     260.37    1.1175753      962.4     861.15    0.8779994   1588.74

                     <331>USP6       X63547      USP6      H.sapiens mRNA for tre oncogene (clone 213).Ubiquitin specific protease 60.7701703   3301.92    4287.26 0.41109437      1819.96    4427.11    0.750741     4032.5

                     <920>VAV1       X16316      VAV1      Human mRNA for vav oncogene                                          0.53593546      4006.75    7476.18    0.6589341    6504.82    9871.73 0.98346066      8044.6

                     <1026>VAV2      S76992      VAV2      VAV2=VAV oncogene homolog [human, fetal brain, mRNA Partial, 2753bp 0.8615917        2202.84    2556.71    0.6209435    1108.44    1785.09    1.0415424   4865.94

                     <1288>VCAM1     NM_001078   VCAM1     Homo sapiens vascular cell adhesion molecule 1 (VCAM1)               0.46504873      2769.17    5954.58    1.1372647    3387.32    2978.48 0.77718574     16541.14
                     <1661>VCP       BC007562    VCP       valosin-containing protein                                            0.8188655       6252.8    7635.93    0.8452392    3049.04    3607.31    0.9359741   7768.66

                     <739>VEGF       M32977      VEGF      Human heparin-binding vascular endothelial growth factor (VEGF) mRNA 1.2188338        390.49     320.38    1.4538356      428.3      294.6    1.1020675    286.78

                     <1170>VEGFB     U48801      VEGFB     Human vascular endothelial growth factor B precursor (VEGFB)
                                                           Human vascular endothelial growth factor related protein VRP mRNA vascular
                     <1228>VEGFC     U43142      VEGFC                endothelial growth factor C precursor (VEGF-C); FLT4 ligand
                                                           Homo sapiens (clone g7) von Hippel-Lindau disease tumor suppressor mRNA
                     <93>VHL         L15409      VHL                                                                              0.4000068      703.92    1759.77    2.4044495    11346.26   4718.86    0.7108644   41639.73
                                                                     sequence
                                                           Homo sapiens cDNA FLJ30489 fis, clone BRAWH2000142, highly similar to
                     <1543>VIAAT     AK055051    VIAAT                                                                        0.85895056         305.46     355.62    1.1929464     330.47     277.02
                                                                    Rattus norvegicus vesicular GABA transporter (VGAT) mRNA
Molecular Medicine




                     <661>WEE1       U10564      WEE1      Human CDK tyrosine 15-kinase WEE1Hu (Wee1Hu) mRNA, complete cds. 1.1353458            403.57     355.46    0.4040339     175.08     433.33    0.7090235    233.29
                                                           Homo sapiens connective tissue growth factor related protein WISP-1 (WISP1)
                     <170>WISP1      AF100779    WISP1                                                                             0.7261742     449.48     618.97    0.7848403    1022.49     1302.8    1.0008513   2539.58
                                                                       mRNA, complete cds
                                                           Homo sapiens connective tissue growth factor related protein WISP-2 (WISP2)
                     <926>WISP2      AF100780    WISP2                                                                              1.070379    5763.82    5384.84    1.3782533    13657.43   9909.23    1.1828314   11123.43
                                                                       mRNA, complete cds.
                                                           Homo sapiens connective tissue growth factor related protein WISP-3 (WISP3)
                     <171>WISP3      AF100781    WISP3                                                                             1.4427121    1574.85    1091.59    1.4040879    1710.53    1218.25    1.3274066   3466.31
                                                                       mRNA, complete cds.
                                                           Homo sapiens wingless-type MMTV integration site family, member 1 (WNT1),
                     <1142>WNT1      NM_005430   WNT1                                                                               0.722033     674.35     933.96 0.81554854      1505.47    1845.96 0.83540356     1805.14
                                                                      mRNA
                     <452>WNT10B     U81787      WNT10B    Human Wnt10B mRNA, complete cds                                       1.1562366       865.79      748.8    1.3521632    2353.44     1740.5     1.51637    1416.79
                     <483>WNT11      Y12692      WNT11     Homo sapiens mRNA for WNT11 gene                                      1.0262862       996.37     970.85    1.6986035    1078.97     635.21    1.3426079    475.31
                     <523>WNT2B      Z71621      WNT2B     H.sapiens Wnt-13 mRNA                                                     1.618        48.54        30     0.7654276       209      273.05 0.86645937      284.19
                     <161>WNT5A      L20861      WNT5A     Homo sapiens proto-oncogene (Wnt-5a) mRNA, complete cds              0.96937907        343.8     354.66    0.6996134     305.85     437.17    0.9137757    344.53
                     <1092>WNT7A     U53476      WNT7A     Human proto-oncogene Wnt7a mRNA, complete cds.
                                                           Homo sapiens cytochrome P450, subfamily 46 (cholesterol24-hydroxylase)
                     <5>CYP46        NM_006668   YP46                                                                           0.92287797       313.88     340.11    1.3304042     687.34     516.64    0.6424137     58.98
                                                                      (CYP46), mRNA
                                                        Human 14-3-3n protein mRNA; Tyrosine 3-monooxygenase/tryptophan 5-
                     <1272>YWHAH   L20422     YWHAH                                                                           1.1457362   44296.81   38662.31   0.9242459   40567   43892    0.90650326   57902.86
                                                                 monooxygenase activation protein, eta polypeptide




                                                                                                                                                                                                                     UNCORRECTED PROOF
                                                        Human protein tyrosine kinase related mRNA sequence; Zeta-chain (TCR)
                     <1114>ZAP70   L05148     ZAP70                                                                           1.1855538    608.77     513.49 0.17092788     73.74   431.41   1.3785318      1148
                                                                  associated protein kinase (70 kD)
                     <1712>YWHAH       #N/A      #N/A                               #N/A
www.molmed.org
Molecular Medicine
               3                                         4                                             5                                             6                                            7                                             8                                            9




                                                                                                                                                                                                                                                                                       UNCORRECTED PROOF
                                     CFS                                           CFS                                           CFS                                          CFS                                           CFS                                           CFS
                          Cy3                           Cy5             Cy3                           Cy5             Cy3                           Cy5            Cy3                           Cy5             Cy3                           Cy5             Cy3
                     Control        Ratio          Patient         Control        Ratio          Patient         Control        Ratio          Patient        Control        Ratio          Patient         Control        Ratio          Patient         Control        Ratio
                          61079.59       0.6528589       21315.98       32650.21 0.32564858               11522         35381.7      1.2295209       36034.15      29307.47       0.8390971       31878.45       37991.37       0.9966526       35680.99       35800.83       1.0778735
                                         0.3060153           26.81          87.61      1.4353039          724.24         504.59      0.5929715         170.42          287.4    0.14832254            22.68         152.91                                                    0.9799851
                            5013.66      1.1319683         3920.38        3463.33      0.8359721         4304.88        5149.55      1.2415731         3972.5        3199.57      1.1286697         3744.17        3317.33      1.2060286         4539.54        3764.04       1.171299
                             224.38      0.9900878          1140.7        1152.12       0.740963         1168.38        1576.84 0.85696787             286.93         334.82 0.82127285              177.05         215.58      1.0297478          397.39         385.91      0.9453498
www.molmed.org




                                       0.92599005            470.94       508.58         1.7051524          2123       1245.05         1.6101255         124.35       77.23         1.6112558         111.37        69.12                                                       0.6182448
                                                                                     0.64592874         324.45          502.3       1.3083402          79.22          60.55      1.1330693         145.86          128.73     0.39877135         207.72          520.9
                           1700.81     0.99556816         1972.31        1981.09      0.5630639        3207.06        5695.73       1.1913848         940.92         789.77       1.608351        5401.92         3358.67      0.8903166         672.83         755.72          1.4065531
                          30541.51     0.83506906        27480.71       32908.31      1.0471067       32910.43       31429.87       0.9822169       14614.67       14879.27      1.0743686        15650.5        14567.16      1.2522571       18115.29       14466.11          1.1258065
                          10552.11      0.6553606         2765.91        4220.44      1.1492505        3525.82        3067.93        0.854155        1388.54        1625.63     0.83806974        7623.82         9096.88      1.5978295        2499.98        1564.61          1.0156876
                           3455.03     0.85842466           836.2         974.11     0.56575805         449.97         795.34      0.81434405         861.69        1058.14      1.1747952        4014.98          3417.6      0.6719075         448.72         667.83          0.7081917
                            185.62     0.35419846            2.32           6.55      0.9506124         191.71         201.67       0.7235173          91.25         126.12      1.0572555         112.64          106.54     0.45731243         127.11         277.95          1.0977196
                          63874.96      1.1886595        49040.79       41257.22      1.9913927      128082.96       64318.28       1.0922741        38357.2       35116.83      1.4733266       94969.95        64459.54      0.8804415       16960.48       19263.61          1.1546446

                                           0.8265386         818.67       990.48         0.5831836     2482.42         4256.67         0.7301025          543.7      744.69     0.76130366             522.3       686.06     0.16607623             58.13      350.02      0.63141054
                            567.95          2.223456      3334.05        1499.49         2.2876427     7624.05         3332.71     0.71480215        7082.51        9908.35      0.9857763        7482.19         7590.15         0.8596004     7737.16        9000.88          1.2704643
                            846.83         1.6959178       599.49         353.49         2.3065226     1387.95          601.75       5.539437         235.98           42.6     0.51299685         199.92          389.71         1.6572875      304.51         183.74          1.4401611
                           3474.56         1.0805216      2123.16        1964.94           1.48111     4774.61         3223.67      0.9631383        2175.19        2258.44     0.69539887        1514.69         2178.16         0.9456674     3133.45        3313.48          1.0209086

                           1306.15         0.5342448         408.74       765.08         0.9539964     2263.91         2373.08     0.98524624            359.94      365.33         0.9853736         635.97       645.41         0.4548453         315.79      694.28          1.1932294

                           1348.47         1.0077087      1396.13        1385.45         1.021416      2678.02         2621.87           1.23955     1452.48        1171.78     0.81461567        1295.19         1589.94         1.1348175     1187.28        1046.23          1.0455632

                            216.33         1.0558187         323.26       306.17     0.25759792             29.92       116.15         11.945001         143.34          12     0.95658994            457.69       478.46         2.6403806         202.57        76.72         1.2237647

                           1672.77         0.836614       1434.04         1714.1         1.399424      3123.85         2232.24     0.85763675        1396.73        1628.58         1.1917233     1841.88         1545.56     0.40663338            267.15      656.98      0.93009543

                            544.17     0.92002934            500.68        544.2     0.83148926            617.73       742.92     0.81991607            510.16      622.21         0.3732388         389.68      1044.05         0.6456749         881.23     1364.82          1.0047343
                           2160.59         0.8641601         779.17       901.65     0.35127768         172.79          491.89     0.39885598            449.04     1125.82         0.5454307     2018.29         3700.36     0.80450404            431.19      535.97      0.41105485
                                            5.018045         186.32        37.13     0.75321585        1120.16         1487.17                                                      1.2531035      189.77          151.44                                                    169.26321
                                                                                      0.5410829         311.68          576.03

                            273.94         0.9644336         277.13       287.35         1.1326737         195.76       172.83         1.1432203         400.23      350.09         0.6461171         319.24       494.09            1.4085         466.96      331.53          1.0983465
                            702.56     0.81060356         1323.74        1633.03         1.0133353     2563.11         2529.38          1.173143         559.12       476.6          0.476185         619.45      1300.86         1.0273387         633.19      616.34      0.97842944
Molecular Medicine




                           4131.34         0.8595381      6587.68        7664.21         0.6866452          6537        9520.2     0.84872454        5492.75        6471.77         0.7534409         4241.3      5629.24     0.80231494            3012.5     3754.76          0.8358633
                          16256.66         0.8458646      5439.51        6430.71         1.7849272     2353.98         1318.81         1.2050743     3810.65        3162.17         1.4518886    13741.08         9464.28     0.68085635        1641.32        2410.67          1.2897485

                           1277.94         0.6670833      1141.94        1711.84     0.23781817            405.87      1706.64     0.95566696        3391.49        3548.82         0.5606555     1493.76         2664.31     0.92368925            959.63     1038.91          1.068356
                           3455.98      1.2612073            961.33       762.23     0.73480666        1404.12         1910.87         1.3894932     1533.82        1103.87     0.96360034        1159.51         1203.31         2.0021067     2271.25        1134.43          1.1009976
                           1484.67     0.48025417            998.53      2079.17     0.57972425        1591.43         2745.15         1.2455565       1370         1099.91     0.96183366         510.07          530.31         0.9077043      186.86         205.86          1.1337596

                           9376.06         0.8474904      9390.21       11080.02         1.1795028    30618.75       25959.03          0.9733297     4364.07        4483.65         1.2392677     7181.73         5795.14         1.0067252     1294.87        1286.22          0.8537225
                            386.58     0.19118452             59.25       309.91     0.17292437          63.65          368.08          1.131858          284.9      251.71         0.7136817         332.54       465.95          2.199557         109.23        49.66     0.86207396
                                        1.3257453            156.08       117.73      1.5791264        1039.46          658.25         3.0312412          323.1      106.59         2.2728379         299.06       131.58                                                     1.397742

                           2157.73         1.0452908      3900.21        3731.22         1.5104523     8983.34         5947.45         1.2385613     2636.29        2128.51         1.6943212     1939.32          1144.6         1.5544113     1603.08        1031.31          1.0551097

                           1054.72     0.71754414         1068.05        1488.48         0.3860431          502.3      1301.15         1.2068788         700.75      580.63         1.3179449     1779.99         1350.58         1.4762319         763.95        517.5         0.7589461


                           3482.01         0.8788076      4357.04         4957.9         2.3963985     8781.65         3664.52          1.092275     4670.59        4276.02         1.1968518     5272.97          4405.7         1.3734804     3518.39        2561.66          1.3186613
                       144.67                                      122.02546      479.56       3.93   0.6864318      197.61     287.88    0.8049023     371.72     461.82




                                                                                                                                                                                                                       UNCORRECTED PROOF
                      7436.95    1.0070714    2419.63    2402.64   0.8378749     4433.95     5291.9   1.1854787      3270.7    2758.97    1.1280234    6415.87    5687.71   0.97265613    1297.64    1334.12    1.1100141
                      3440.95     1.151855    3301.85    2866.55   0.7323682     4194.47    5727.27   0.6887124     2820.78    4095.73    1.1913592    5765.13    4839.12     0.921087    3215.57    3491.06    0.9842154
                     10620.87    0.7477352    8923.95   11934.64   1.6304036     26042.6    15973.1   1.0799555    12369.96   11454.14   0.80447775    7412.08    9213.53    0.8560189    7345.19    8580.64    1.0664425
                       534.13    1.0931505      749.3     685.45    2.287248     4742.54    2073.47   1.6603944      787.11     474.05    1.1400949     679.85     596.31    1.0088751      90.94      90.14    1.5351027
                      1838.49   0.95909363    1794.56     1871.1   1.1319194     2310.27    2041.02   1.1010665     2227.05    2022.63   0.73201466    1497.68    2045.97    1.0371398    2110.32    2034.75     1.021876

                       541.88   0.72398204     211.41     292.01   0.22584434    1123.93    4976.57   0.22481447     153.89     684.52   2.1077302       25.63      12.16                                      0.32615715
www.molmed.org



                       299.26   0.6999195      434.93      621.4   0.7432332       398.7     536.44   1.9114876      160.24      83.83   0.7720006      616.18     798.16   0.7071058      235.94     333.67    0.7432921
                                 4.756394      152.49      32.06    0.8001744    1339.54    1674.06   0.99386984     137.81     138.66   0.5620837      183.97      327.3   0.35907555     119.17     331.88     1.068061
                      3547.12   0.6566275     2515.31    3830.65   0.57971543     2710.9    4676.26    0.8591698    2238.12    2604.98   1.0995251     2840.26    2583.17   0.35963488     199.36     554.34   0.73811203

                        469.4                                      3.8799212       19.71       5.08    1.569525      235.57     150.09    1.671777      613.91     367.22   0.48247257     108.18     224.22
                                2.6939676      158.54      58.85   0.6422911      603.06     938.92   0.81326836     181.92     223.69   0.61385256     212.35     345.93   0.99067694     195.52     197.36    0.6768154
                     29966.85   1.1685055    13173.17   11273.52    5.841786     45160.8    7730.65    2.3055758    9800.98    4250.99    2.2590778   16265.18    7199.92     2.011853    6507.52    3234.59    1.4772903
                                                                                                       1.2108452     321.77     265.74                                       1.3208867     179.35     135.78    0.9173531
                     28316.31     0.774934   14843.17   19154.11    1.5496206   26752.03    17263.6    1.0469183   12773.68   12201.22   0.38393545   14679.76   38234.97    1.2811702   13792.26   10765.36    1.0417846
                     13443.48    0.6304965    3974.82    6304.27   0.12840694     962.36    7494.61    0.9391726   10392.48   11065.57    0.6303778    7514.23    11920.2     1.126867    6356.77     5641.1    1.0417036
                     24002.53    0.9172283    13522.1   14742.35    1.3326426    27479.9   20620.61    1.3560944   12185.24    8985.54    0.9760237   14479.73   14835.43   0.99939686    7704.95     7709.6    1.0075176
                                0.75247544     383.01       509     1.6081388     325.23     202.24    0.9233983     558.97     605.34                                       1.2617345     201.07     159.36   0.82906973
                      7719.19    1.3767228     5746.4    4173.97    0.8106952    3699.94    4563.91    1.4978186    2011.78    1343.14   2.1277764      3643.2    1712.21    1.5011255     3374.5    2247.98    1.2109556
                       525.38    1.0688869     328.33     307.17    3.2228239     571.31     177.27    1.3436384     511.98     381.04   1.5343925      735.02     479.03    1.8188987     318.38     175.04    1.0741924
                        57.34    0.8078407     353.81     437.97    1.1184095     382.25     341.78    1.6191176     198.18      122.4   1.0996759      366.39     333.18     4.173308     302.69      72.53    2.5479636
                     41726.18    0.6368584   12015.04   18866.11    0.6507731   10372.62   15938.92    1.3272808   11298.77    8512.72    1.345181    15781.07   11731.56    1.0115242    5801.88    5735.78   0.84660727
                      5941.15    0.6174144    2315.73    3750.69    0.2866326    1957.48    6829.23   0.71628046     357.03     498.45   1.3431758     8313.17    6189.19   0.39820382    1155.48    2901.73    0.8297762

                      8440.33   1.0787607     3770.15    3494.89   0.7217837     4760.64    6595.66   1.9600682     3163.55      1614    1.2779677     6152.43    4814.23   0.9317864     2574.06     2762.5    0.8005321
                     19963.87   0.7943758     3645.16    4588.71   1.9075745     2905.98    1523.39   1.2924159      841.66     651.23   0.5606192     8921.66   15913.94   0.9916669      573.59     578.41   0.91609555
                     16659.22     0.96973     9733.51   10037.34   0.8714027     5066.44    5814.12   0.9784675     1310.08    1338.91   1.1582929    37886.06   32708.53     1.10447     2499.25    2262.85    1.2311783

                     25488.51   0.98713946   17686.36   17916.78   1.8383801    14189.04    7718.23   1.3004185     6030.34    4637.23   1.2616565    31739.43   25156.95   0.6730106     6909.45   10266.48    1.1008167
                      3522.01   0.36267817     922.86    2544.57    1.6403385    1102.57     672.16    0.8277207     888.79    1073.78    1.2313464    3809.17     3093.5    0.4338127     481.71    1110.41   0.94414437
                     25284.36    1.4402195   15063.86   10459.42   0.44447348    7772.77   17487.59    0.9397385    5594.31    5953.05   0.78590167   29250.56   37219.11   0.39597017    2141.89    5409.22    0.9156902
                      2441.57    0.8662797    3025.56    3492.59    1.0673004     6779.3    6351.82    0.8886795    2871.27    3230.94    0.9617785     4053.3    4214.38    0.8627155     827.81     959.54   0.97071683
                        390.9   0.71584535     168.51      235.4    1.6717634     555.41     332.23   0.95213187     251.22     263.85   0.74941427      63.97      85.36   0.27468857     102.11     371.73   0.75206953
                                 1.0511115     309.71     294.65   0.81924945    1300.28    1587.16    2.1147542     274.77     129.93    1.4941576     320.96     214.81     1.512525      364.7     241.12     1.255217
                     13445.69    1.0956074    9506.19    8676.64    1.0099005   14047.16   13909.45    1.9445487   11653.72    5993.02    0.9599894    12833.6   13368.48     2.142169   12403.78    5790.29    1.9323697
Molecular Medicine




                      1426.38   0.64083576    1567.01    2445.26   0.27923232    1010.31    3618.17    1.1000162    2695.15     2450.1     1.418377      2248     1584.91   0.97741467    1326.86    1357.52    1.3399079
                      3981.55    0.9786756    1447.52    1479.06    1.2625165    7477.09    5922.37   0.97335315    3081.85    3166.22    1.0146389    3408.72    3359.54    1.0993918    3532.72    3213.34    0.9460405
                                                                   0.32855004      109.9      334.5    1.0427022     941.07     902.53    1.5357316     477.29     310.79    2.6013858     596.94     229.47    14.987225

                     27795.45   1.2142329    12854.21   10586.28   3.1372688    41218.38    13138.3    1.050205     2828.16    2692.96   0.76702684    19299.3   25161.18    1.338793     8658.27    6467.22    1.0948378
                                0.8642367      668.15     773.11   0.8072139      670.27     830.35   1.0681455      676.04     632.91   1.1710564      518.86     443.07   0.8233498      204.94     248.91    0.8284026

                       593.89   0.8790241      560.58     637.73   1.9301425     1493.66     773.86    1.687381      142.01      84.16   1.3593384      359.98     264.82                                         2.68621
                      7306.87   0.91577244   10448.24   11409.21   0.89447004   11041.23   12343.88   0.8720774     6460.21    7407.84    1.131339     7637.85    6751.16   1.2498909     5844.84    4676.28   0.92799187
                      2001.99    0.7351569     976.95     1328.9                                      0.9747251     1670.25    1713.56   1.0556213     2667.08    2526.55   0.9915495      709.88     715.93   0.86992854
                     15306.46   0.90576553   12666.47   13984.27   0.79406273    7454.59    9387.91    1.063609     4629.55    4352.68   1.4072522    12927.37    9186.25   0.8221921     3550.11    4317.86    1.0662903
                     19484.83   0.94952714    8504.25     8956.3     2.232442   15731.35     7046.7   1.1482378     4114.32    3583.16   0.9570023    15951.82   16668.53   0.8938448     4504.62     5039.6    1.0137383

                     14580.09   0.96403766   11582.18   12014.24   1.4179008     7827.11    5520.21   1.1998695     1103.94     920.05   1.0986371     2852.93    2596.79   0.67824215     572.26     843.74   0.98680854
                      7459.92   1.2004777     4276.57    3562.39    1.290288      8414.2    6521.18   1.2095139     2178.77    1801.36   1.9415492     6015.56    3098.33   1.0255127     1503.33    1465.93     1.300234

                       675.94   1.4890815      783.51     526.17   0.76284003     440.83     577.88    2.160032      214.88      99.48   1.0961763      819.03     747.17   0.36465696      86.73     237.84   0.28957036
                       313.94                                      0.72206235     142.99     198.03   1.2467043      271.42     217.71   1.3006966       360.41     277.09    1.0379968     208.71     201.07    4.1725574




                                                                                                                                                                                                                        UNCORRECTED PROOF
                      2533.74   1.0132229      911.09      899.2    1.1039208    4673.89     4233.9    1.316114      433.37     329.28   0.5872139      1458.24    2483.32    0.8322622     793.82     953.81    0.7524421
                       374.97   1.4048221     1472.38    1048.09     2.927151    5000.13    1708.19    1.7811645    1170.51     657.16    0.8545079       401.2     469.51    0.8224238     664.65     808.16    1.3295733
                         828    1.1208128     1512.66    1349.61    1.2117451     2987.8     2465.7    1.4576274     739.95     507.64    1.2606418      743.64     589.89     2.365022     608.26     257.19    0.9306364
                      3140.63   1.3849211     5302.96    3829.07    1.4061227    6138.85     4365.8   0.96037346     2065.6    2150.83   0.89029396     4104.46    4610.23    0.7845361    1274.33    1624.31    1.0512772
                     48315.17   0.8618536    22832.88   26492.76    2.5788813   64920.45   25173.88    0.9482265   24047.65   25360.66   0.52280915    16425.43   31417.64   0.93901867    6129.51    6527.57   0.98861325

                                0.31967768     103.94     325.14                                                                                                              1.3295135     199.56      150.1
www.molmed.org




                     26580.71   1.9187113    16284.89    8487.41    3.9765463   33711.45    8477.57   1.8474451     7135.11    3862.15   1.9048532     26786.58   14062.28    0.6276387     5460.3    8699.75    1.0042676

                     25844.29   1.2063001    13198.77   10941.53    1.5564346   14037.92    9019.28   0.61325324    6091.69     9933.4   1.2495005     22907.37   18333.22    0.6569587    4767.24    7256.53   0.77911305
                     37411.56   0.9212236    21464.84   23300.36    1.0576373   44196.26   41787.73   1.1610354    20114.87   17324.94    1.112498     20735.84   18638.99    0.8534711   11049.25   12946.25     0.978754

                      3045.85   1.3971536     4311.56    3085.96    4.7587876    8276.96     1739.3   1.0432587     1361.15    1304.71   1.0418442      1574.56    1511.32    1.4629426    2455.71    1678.61    1.0869802
                     15448.08   0.83801764   10074.17   12021.43   0.69795126     5956.4    8534.12   1.1762944     5514.28    4687.84    1.765424      5956.17    3373.79    0.5265807     3954.8    7510.34   0.95956284
                     17340.19   0.81388825   10696.38   13142.32   0.70139426   13249.94   18890.86   1.3055797     8079.88    6188.73    1.173819     18473.27   15737.75    0.7271423    4098.69    5636.71    0.9629184

                     22468.25   0.8259882    12195.36   14764.57   0.46108487    7353.76   15948.82   0.9698913    19850.65   20466.88   0.90966433    11113.77   12217.44   0.77943677    6808.84    8735.59   0.77737176

                     28582.58   1.0425179    22684.97   21759.79    1.7763098   14632.44    8237.55   1.0565081      3132.8    2965.24   1.1018201     26619.38   24159.46    1.3074179    2931.95    2242.55    1.0482352
                     19850.76   1.0149305     5719.58    5635.44   0.77663165    2355.92    3033.51   1.5160424     1704.82    1124.52   1.5076926     15906.91    10550.5    1.5253438    2000.58    1311.56     1.260528

                     63874.96   0.7838175    62852.25   80187.35   0.89808285   59775.89   66559.44   0.7972668    28705.32   36004.66   1.0023804     64612.98   64459.54   0.74409044   34206.17   45970.45    0.8321968
                      4656.73   0.8304936     4424.87      5328     0.1980576    4243.84    21427.3   0.81241983    5423.43    6675.65   1.7278636     12550.44    7263.56    0.9934947    3650.01    3673.91    0.8663321

                     15033.35    1.199289     3788.35    3158.83    1.8232297   10065.23    5520.55   1.3291582     1510.07    1136.11   1.7064016     13001.91    7619.49    1.7482839    4064.55    2324.88    1.3063104

                       216.83   0.84983087     256.19     301.46    1.5891964     358.92     225.85   1.0253695      224.72     219.16    0.652832       356.27     545.73   0.28111595      74.06     263.45    1.0616452

                     36802.66   0.97665066   17296.29    17709.8    0.9749987   23396.12   23996.05    1.293565    13727.17   10611.89   1.1010284     20063.71    18222.7     1.625603   16578.89   10198.61   0.94834906
                     19550.47   1.1203967    19283.64   17211.44    3.2203474   64353.78   19983.49   0.73349714    3912.98    5334.69   0.70063597     11467.8    16367.7    1.6141735    6454.87    3998.87   0.99565566
                      6093.49   1.0014305     3304.22     3299.5     1.295183    5008.99     3867.4    1.2281114    1145.57     932.79    1.3560749     5578.39    4113.63    1.0821013    1586.22    1465.87   0.73709565

                      2863.81   0.49167967     778.56    1583.47    0.2262972      292.6    1292.99   0.5666821      280.74     495.41   1.1986079      3586.81    2992.48   0.45680287     595.47    1303.56   0.75807554


                       635.96   0.5488941      363.56     662.35   0.77109414     611.84     793.47   1.0776674      457.75     424.76   0.7034451       646.67     919.29    0.4304066     543.78    1263.41    0.9059164

                      7928.52   1.0439593     9318.59     8926.2    0.8609803   15356.72   17836.32   0.88981986    5675.68    6378.46   0.85466564     4777.94    5590.42    1.0012592     7108.3    7099.36   0.77804816
                      7886.74   0.8351853     9427.68   11288.13   0.91203195   23242.33   25484.12    1.0594639    9065.96    8557.12    1.4026703    32668.33    23290.1    1.2812214   12638.16    9864.15    1.2883425
Molecular Medicine




                      63700.5   0.9847533    62676.97   63647.38   0.56604713   36407.18   64318.28   0.90147305   58266.71     64635     1.8018979   116149.51   64459.54    1.3840351   46058.31   33278.28    1.4797857

                       245.96   0.77212244     199.03     257.77   0.82201195     709.98     863.71   0.8719886      336.98     386.45   1.3790458      1610.56    1167.88                                       1.7690303

                     36107.76    0.708694     9204.22   12987.58    0.9277125    3576.48    3855.16   1.4258626     1142.23     801.08   0.8554303     12959.47   15149.65    1.0273933    1726.37    1680.34    0.9705208

                     14958.88   0.86756194    7316.87    8433.83    1.2559273   14583.74   11611.93   1.1024524     6098.37    5531.64   0.92047083       9504    10325.15   0.72818214     2466.2    3386.79    0.8733394

                       125.78   1.1428773      242.77     212.42    1.1225336    1292.53    1151.44   0.74295086     373.89     503.25   0.5456492       173.32     317.64    1.3486797     274.78     203.74    1.0540313

                     34069.29    1.016213    17410.79   17133.01     2.440031    48790.4   19995.81   0.7354782      7902.5   10744.71   1.3402725     17871.38   13334.14    0.6672384    2579.19    3865.47    1.3196185

                       374.31   0.9552083      155.25     162.53    3.6999505      74.48      20.13   0.24338038      15.35      63.07   1.0101976        485.4      480.5                                       0.4702906
                      3155.53    1.221657     3206.19    2624.46    0.5270189    2737.61    5194.52   0.7439861      818.98     1100.8    1.051478      4196.89    3991.42    1.6425947     961.23     585.19    1.1151538
                      1780.67    0.722822     1270.02    1757.03   0.39452264     931.46    2360.98   0.7713543     4745.68     6152.4   1.5894129      4998.37    3144.79   0.74830234     1335.6    1784.84     1.070033

                      5215.96   0.56387866    1609.71    2854.71     1.018377    3113.26    3057.08   1.1121608     1851.87    1665.11   1.2011212      1864.08    1551.95   0.32514083     221.59     681.52    0.9251098
                       266.36                                       1.1165162    1299.77    1164.13   1.2013725     1729.58    1439.67   1.0861933      1111.48    1023.28    2.0394409     422.98      207.4    1.1454347
                       6751.1   1.1264614     3353.96    2977.43   0.33881873     931.04      2747.9   1.2176512      1002.2     823.06   2.5987816     5011.62     1928.45     1.36292      1452.9    1066.02   0.8129998




                                                                                                                                                                                                                         UNCORRECTED PROOF
                      9399.57    1.0898881    2475.31    2271.16      0.86971    1287.11     1479.93    1.6529421     416.31     251.86   0.89308995      6372      7134.78   0.49951145     444.77     890.41    0.8466141
                      9550.31   0.80012214    4556.84    5695.18   0.34061408    4148.39    12179.15    0.8493422    2740.53    3226.65    1.3716539   13819.77    10075.26   0.86040443    3196.48    3715.09    0.9230387
                      1081.19   0.94930893      960.9    1012.21   0.73666394    1281.39     1739.45     0.980848     467.07     476.19   0.61412054     509.37      829.43     0.716139     365.99     511.06    0.6509125
                     11637.21   0.49916887     4723.8    9463.33   0.18458736     897.94     4864.58    0.6841984    1889.53    2761.67    0.8955459    8308.23     9277.28   0.44030952    1428.91    3245.24    1.0315784
                     11279.57   0.75565195    3856.81    5103.95    1.9683177    8971.69     4558.05    1.1117744   10135.28    9116.31    1.2442497    7758.27      6235.3   0.74902683    4108.27    5484.81    1.2770077
                      22263.1   0.53637844   10474.93   19528.99    0.6989413    4169.15     5964.95    1.1062351    1606.32    1452.06   0.72141993   11801.65    16358.92    0.6070112    1799.26    2964.13    0.7769965
www.molmed.org



                                                                                                        1.0984226     476.32     433.64   0.70081025      94.28      134.53    0.7903472     651.42     824.22    1.1302146
                      4845.07   0.80167127    2442.62    3046.91    0.2634909    1214.05     4607.56    0.6940107    6093.24    8779.75    0.6527914    7295.76    11176.25    0.6591184    2222.91    3372.55      0.66729
                                 0.6275209     191.67     305.44   0.49207592     465.43      945.85    0.9448151      478.7     506.66    1.1111925      455.1      409.56    0.8689645     368.58     424.16     0.865327
                      1120.33    1.3352369     341.38     255.67     0.838679     185.65      221.36    1.2436405       220       176.9    1.1620531     420.64      361.98   0.89723176     460.89     513.68    0.8481112
                      6244.06    1.5653876     804.03     513.63    3.3366911    7207.22     2159.99   0.99112993     2146.5    2165.71    1.1008452    2608.75     2369.77    1.2471414    3820.63    3063.51    1.1463989
                     28028.44   0.90027994    6882.91     7645.3   0.62908113    3556.68     5653.77    1.1905482    6905.12    5799.95    0.5869023   11906.95    20287.79   0.77776086    6732.08    8655.72   0.72691554
                        347.1    0.5441565      80.41     147.77    0.8779311      92.85      105.76    0.8513751     179.24     210.53    1.6983309     391.72      230.65   0.57338333       70.4     122.78   0.14850768
                                 0.7281774     307.32     422.04    0.6363394     524.77      824.67    1.5507228     267.05     172.21     2.833635     312.55       110.3   0.36339214     301.71     830.26    1.7636546
                      3130.34    0.6929022    2990.24    4315.53   0.36865088    1428.36     3874.56     0.695544    3142.92    4518.65   0.39910513    2142.56     5368.41    0.6826973    1297.63    1900.74   0.70200914

                     30989.59   0.95046455   13740.79   14456.92    1.2258463   20094.98    16392.74   0.8365463     6377.11    7623.14   0.7394282    19963.23     26998.2   0.97529334    6867.85    7041.83   1.0417504
                     17863.01    0.9048102   11640.13   12864.72   0.22855255    1968.13     8611.28   0.72116596     7552.8   10473.04    1.4438387   19891.03    13776.49   0.74487585    9076.99   12185.91    0.9842907
                       270.54    1.0057336      59.64       59.3                                        0.8572562     324.18     378.16    0.6275557     794.04     1265.29   0.81574965     274.72     336.77    0.6426639
                                  1.638582    1040.86     635.22    0.6736364    1739.41     2582.12   0.50959015    1082.93     2125.1    0.5368915     998.28     1859.37   0.49381685     543.48    1100.57   0.57847816
                       592.82   0.34391606     511.95    1488.59   0.47431663     627.26     1322.45      0.96875     241.49     249.28    0.5460573     679.47     1244.32    1.0431026     338.08     324.11    1.3087149
                      8356.42   0.82077366    6097.79    7429.32    0.4901173    3850.69     7856.67     0.857264    4598.75    5364.45    1.0181782   10043.81     9864.49    0.8081497    4834.57    5982.27    1.0020452
                                0.41697326         51     122.31   0.44586667     576.47     1292.92     0.278904      44.99     161.31   0.24379992     112.56      461.69   0.14176455       59.5     419.71    0.6663018
                                 0.8522298     611.33     717.33    1.0564365    1138.68     1077.85   0.55673033     207.46     372.64   0.97775936     259.82      265.73   0.27169108      35.04     128.97   0.53718716

                     16425.92   1.1395236    14073.22   12350.09    1.1980566   30076.55    25104.45   1.3344617    17161.47   12860.22   0.9159103    10796.32    11787.53    1.374368     20479.8   14901.25   1.2585032
                      3013.78   1.5133593     2160.29    1427.48    5.0294447    9302.36     1849.58   11.042919      231.57      20.97    0.151991      154.09     1013.81   0.72628224     252.63     347.84   1.3713179

                      5699.21    1.391262     2415.69    1736.33    3.0205064   40395.86    13373.87   1.6713684     5796.74    3468.26   1.9197943     6584.05     3429.56   2.0663784     3477.88    1683.08   1.2440754
                     63874.96   1.9320762    74051.75   38327.55     7.227034   254857.62   35264.48   1.0589697    30290.56    28603.8    0.801381     23747.1    29632.72   0.7076187    12848.58   18157.49   0.9133994

                     20137.63   0.6707669     1110.24    1655.18    0.0863087     547.74     6346.29   0.65289694    3219.82    4931.59   0.5459276     9023.55    16528.84   0.7129985     5815.18    8155.95   1.2925614

                      2094.52   0.6945189     3417.45     4920.6   0.63723963    6866.92    10776.04   0.6612151     2414.89     3652.2   1.3221338     4025.99     3045.07   0.99220455    1154.42    1163.49   0.6595391

                     90020.38   0.88896424   37118.47   41754.74    0.9331027   39908.02    42769.16   0.7646218     20431.2   26720.66   1.3355843    86091.15    64459.54   0.94658697   26376.92   27865.29   0.9557439
                     63874.96   1.0804502    69403.35   64235.59    1.2059386    77563.9    64318.28   0.8105714    33336.96   41127.73   0.7983045    51458.34    64459.54   0.9693795    40553.35   41834.34   0.8338989
Molecular Medicine




                      7840.05   0.8595562     2747.58    3196.51    1.1186689     2470.2     2208.16   1.5704145     1453.56     925.59   3.0218592     7904.67     2615.83   2.1594179     2556.47    1183.87   1.9134599
                      38640.8   0.8759667    14354.23   16386.73   0.26117876     4846.3    18555.49   1.2095257     75514.9   62433.48   0.9161341    38404.87    41920.58   1.0173298    15914.06   15642.97   1.0249425

                      9231.89   1.1949393     1648.55    1379.61    3.5800889    6356.77     1775.59    1.352504     1599.62    1182.71    4.420635      3533.9      799.41   2.6373851     1175.72     445.79   1.4689207
                     63874.96   1.2182329    32251.01    26473.6    0.8934048       7662     8576.18   1.4725174    10990.34    7463.64   2.3740394    122248.41   51493.84   1.1730484     10311.6    8790.43   1.0100466
                     63874.96   1.4296613    69099.96    48333.1     3.107261   104375.41   33590.81   2.3536212    85761.54   36438.12   2.7240963    110610.67   40604.54   1.9561045    54772.55   28000.83    1.215172
                     48860.46   1.7900198     21321.3   11911.21     8.457839   117576.23   13901.45   3.2939417    11459.92    3479.09   4.6105804     44660.94    9686.62   2.0498188     6538.02    3189.56    1.436671

                      2307.12   0.6615564     1364.48    2062.53   0.35275856      445.4     1262.62   0.72028357     870.83    1209.01   0.59197295    1766.53     2984.14   0.86285657     335.47     388.79   0.81810784
                     14285.46    1.0524921   15243.38   14483.13    0.7154338     6570.2     9183.52   0.5136363     2786.22     5424.5   0.45060503   10656.76    23649.89   0.6196871     2374.74    3832.16    0.5317572
                     29375.82    1.5522764   22317.87   14377.51     2.850928   45667.74    16018.55   1.4872742    25286.13   17001.66    1.1375948   18534.73    16292.91   1.1173218    11298.47    10112.1   0.70614773
                     15255.98   0.49791697    4845.22    9730.98    0.4506789    4209.12     9339.51   1.5902789    15399.48    9683.51   0.95037335   11861.22    12480.59   1.1819434     7046.77    5962.02    1.5477171
                      1305.46    1.0762769     695.77     646.46    1.1094295    1079.83      973.32   0.8206305      541.69     660.09    1.0351235    1988.11     1920.65   0.8337186      645.69     774.47    0.7377793

                      2511.23   1.0413946     7003.92    6725.52    0.8927368    9279.74    10394.71   1.0562793     4618.18    4372.12   1.5519016      3481.8     2243.57    1.027972     2407.86    2342.34   0.9842233
                      5691.37    1.1466271    4721.73    4117.93    1.8347832    7648.11      4168.4   0.98102206    7399.84    7542.99   0.93830436    7539.97     8035.74   1.0343465     2401.98    2322.22   0.97072566
                     11264.82   0.77440816   10485.44   13539.94    2.2565596    16523.5     7322.43   0.52935404    8471.94    16004.3      1.09939    11031.5     10034.2   0.7957464     4278.41     5376.6    0.8530512
                                                                                                                                           0.34019613      142.93     420.14   0.81937015       96.53     117.81




                                                                                                                                                                                                                           UNCORRECTED PROOF
                      1112.77   0.9931461      536.14     539.84     1.44814     1124.64      776.61   0.8824872      901.39     1021.42    1.029965      1348.08    1308.86   0.67567635      295.98     438.05   1.0611752

                      5622.66    1.007128     3684.88     3658.8   0.72768146    3281.96     4510.16   1.3761483     1451.52     1054.77    0.899412      2029.73    2256.73    0.7444485      244.06     327.84    1.493046
                      1233.09   0.85742027    1307.06    1524.41   0.28833732     2033.77    7053.44    1.1882851     1335.68    1124.04   2.0466533       953.72     465.99     2.165881     2080.87     960.75     1.170325
                      1410.68    0.7041867    1070.73    1520.52   0.46660456      971.69    2082.47    0.8371367      703.22     840.03   0.5440891        1554     2856.15    0.4870746      372.69     765.16   0.86778647
                     63874.96    2.0135775   43915.28   21809.58    15.843645   563532.94   35568.39     7.936877   221838.98   27950.41   10.842115    111890.74   10320.01     4.287164    276065.6   64393.52    2.9420674
www.molmed.org



                     51130.79    1.3833905   39505.61   28557.09    0.7007353    23392.66   33383.02    1.4111334    18687.23   13242.71   2.3866935     36900.62   15460.98    1.4796739    20879.13   14110.63    1.1787084
                     46939.42    1.1952249   28610.29   23937.16    2.0066364     99909.6   49789.59    1.0062923    31887.04   31687.65   1.6844944     34932.49   20737.67    1.6379132    27756.75   16946.41   0.88601804
                     15303.88   0.88118166    4537.83    5149.71    1.5004054     9401.21    6265.78   0.79213095     5622.53    7097.98   0.5854488      7615.05    13007.2   0.79776955     5033.28    6309.19    1.1963437

                      7550.67   2.0050259     2485.41    1239.59   0.9368054     1581.29     1687.96   1.3538185     1029.43      760.39   1.1342416      3611.55    3184.11    1.5574347     1412.64     907.03    2.678289
                     21316.08   1.1463464    18724.25   16333.85   2.8020928    74146.57    26461.14   0.9223808    12577.87    13636.31   0.7299933     29878.78   40930.21   0.91167974    16084.52   17642.73   0.9911222

                      1150.04   1.0718595      351.72     328.14   1.2253497     1604.24     1309.21   0.8644275      184.27      213.17   1.1320196      1849.12    1633.47    0.9982816       307.9     308.43   1.4747032
                     41644.39    0.8692007   24663.12   28374.48   0.98145074   33139.98    33766.32    1.1062473   19206.91    17362.22   1.5076344     22140.11   14685.33   0.85587263     7095.21    8290.03    1.0924733
                      2175.63      2.35366    2319.32     985.41   0.34465218    1146.42     3326.31    1.2866825     539.21      419.07   0.7938038      3234.56    4074.76   0.52683264      734.51     1394.2   0.68469703
                      7406.98    0.6588067    3354.96    5092.48    1.1300724    5646.35     4996.45   0.75676894    4589.41     6064.48   0.5193584      4879.18    9394.63    0.7127364     5705.12    8004.53    0.8505595
                      3977.39    1.3109347    1536.73    1172.24    3.0867214      668.8      216.67    4.7487473     1895.7       399.2    15.77356      3707.26     235.03    4.1926947     1353.36     322.79    3.5248928
                     73764.06    1.1484782   20722.36   18043.32   0.12142908    1395.61    11493.21    2.4404755   44680.86    18308.26   1.9235386     52827.91   27463.92    0.8968401    16937.92   18886.22   0.79587096
                        524.3   0.83342105     490.86     588.97    0.8417376     653.18      775.99    0.9035106       393       434.97     1.41011       701.29     497.33    11.900709       16.78       1.41    1.0065585

                      19043.4   0.9859482    13489.28   13681.53   1.0339594    18598.82    17987.96   0.82929766     5325.6     6421.82   0.94082475    24656.59   26207.42     1.146467     7175.37    6258.68   0.7792423
                                0.18121184     106.23     586.22                                                                                                               0.098945655      53.68     542.52
                        944.3    1.6340548    1122.04     686.66    2.7868137    3826.49     1373.07   1.9326504     1658.62      858.21   1.3805373      1138.75     824.86     1.8611033    1898.53    1020.11   1.2934748
                      1105.36   0.68298465     723.67    1059.57   0.34842414     832.11     2388.21   1.2370706     1086.42      878.22   1.0132178       768.85     758.82    0.33603844      94.41     280.95    1.183391

                      5691.02   1.2500461     6896.13     5516.7   1.1174178     7779.82     6962.32   0.9928918     4714.28     4748.03   1.3381577      4835.54    3613.58    1.2265466     3504.44    2857.16   1.2264502
                      8382.46   0.53534466    4263.94    7964.85   0.45283538    3031.52     6694.53    0.9378198    1827.37     1948.53    0.930532      4159.58    4470.11   0.41158777      837.54     2034.9    0.8046718
                      1303.98    1.2019341     610.27     507.74     1.206279   21204.19    17578.18     0.976673     874.64      895.53   1.1463445      1739.83    1517.72    1.2787127     1636.65    1279.92    1.2677026
                       471.31   0.99469984    1525.79    1533.92    1.1297684    2386.41      2112.3   0.82398766     555.31      673.93   1.2032526       1306.6    1085.89    0.7502808      474.29     632.15   0.93451095
                      1246.34    0.7780395     208.04     267.39    1.4091271     674.07      478.36      0.88891     467.78      526.24   0.9514547      1674.96    1760.42    1.0935421      698.85     639.07    1.1911589
                     63874.96    0.7651559   57611.38   75293.65   0.83383805   50515.91     60582.4    0.8298158   26666.22    32135.11   2.4063518    155112.33   64459.54     1.090511    32673.41   29961.56    1.5271407

                       742.18   0.5140818       38.88      75.63                                       0.9340011      281.62      301.52   1.1186223      1019.49     911.38    1.1799935      292.78     248.12   0.7687581

                      5099.94   1.4034666     2795.93    1992.16   2.0220003     5279.16     2610.86   1.3956589      606.33      434.44   1.0855325      2772.07    2553.65     2.193088     1159.99     528.93   1.3429936
                       508.57    0.7194014     395.16     549.29   0.40934092     386.25      943.59    1.0671935     171.53      160.73   0.35045236      142.55     406.76    0.7582892      349.45     460.84   0.6698897
Molecular Medicine




                      2638.46    0.7607828    3664.47    4816.71   0.55913967    1865.67     3336.68    1.0170774    2102.96     2067.65    0.6078725     1764.97    2903.52   0.98619264     2040.61    2069.18   1.2970722
                     63874.96    1.2131658   18382.87   15152.81   0.13533057    6233.91    46064.32   0.63485223    7718.73    12158.31    0.5290234    23868.07   45117.23   0.41126412     7227.42   17573.67   0.3604375
                     59138.83    0.7329747   18423.18   25134.81    1.2786331   49452.53    38676.09    1.2839465   24165.85    18821.54    1.1198876    49122.87   43864.11    1.1105475    40424.32   36400.35   1.2899137
                       544.11    1.0529882    1331.83    1264.81   0.85626185    7223.93     8436.59    0.9123808    2045.64     2242.09    0.7347956     1000.38    1361.44    0.7408879     1121.03    1513.09   1.1476737
                      1741.27   0.99952364    1678.63    1679.43    0.7164192    3603.51     5029.89    1.2465029    2238.37     1795.72    1.1264623     1594.53    1415.52     0.961386      807.92     840.37   1.0613014
                        86.64    1.3266436     932.71     703.06    0.7399339     5733.4     7748.53    1.0394922     891.77      857.89   0.84068215     1264.47     1504.1    0.7577784      364.84     481.46   0.9068323
                      2296.16    0.6590486     573.57      870.3   0.24176085     589.06     2436.54    1.2010901     744.82      620.12    0.7965795     1439.69    1807.34    0.5409759      633.71    1171.42    1.075097
                       789.44    1.7323124     145.93      84.24    0.2717037    2931.21    10788.26    1.2637175     862.74       682.7     1.644754      918.48     558.43    1.1220821      489.34      436.1   1.2654876
                     63874.96    0.8289407   20471.32   24695.76    0.5133822   11200.13    21816.36    1.6477807   25881.64    15706.97    1.0326351    12827.62   12422.22    1.3408316     9888.66    7375.02   1.3852513

                        84.98                                                                          1.3407062     1545.66     1152.87   1.6723349      2618.91    1566.02    1.6785376     1523.34     907.54   0.96249056

                     63874.96   0.9547314     22314.9   23372.96   1.3265647    19415.76    14636.12   1.9848647     7920.92     3990.66    4.871983    103476.24   21239.04    2.0940404     7434.66    3550.39   1.9353882
                      7395.97   1.2111013     8076.35     6668.6   1.9533077    19181.62     9820.07   1.0301769     8252.51     8010.77   0.8714353      8671.87    9951.25   0.68929696     3480.04    5048.68   1.1763616

                      5239.99   0.6454717      369.61     572.62   0.26217675    1677.58     6398.66   1.6866584      579.89      343.81   0.5125249      1709.45    3335.35    1.1085169      277.75     250.56    1.068786
                      2680.41    1.228133     1342.03    1092.74   0.30776924     163.13      530.04   1.9499024     2337.66     1198.86   6.0130353      7850.98    1305.66   0.96707684      727.88     752.66   1.0535799
                     29963.33   1.4590616    28770.39   19718.42     2.555687   51472.15    20140.24   1.4291952    10686.75     7477.46   2.3336535     21184.86    9077.98    2.1399872    16248.56    7592.83   1.3993816
                       2665.3   1.1740383     6347.11    5406.22    2.5184052   12091.82    4801.38   1.0797682     4103.54    3800.39    1.992598      5023.2    2520.93   1.6331671     2765.05    1693.06   1.2484125




                                                                                                                                                                                                                       UNCORRECTED PROOF
                     18743.72   1.8100435    38059.82   21027.02    2.6419816   87937.07   33284.51   0.7904666    15761.28   19939.21   1.2300423    33124.19   26929.31   0.89947665   20579.89   22879.85   1.1260997
                      3508.95    0.516126     1133.81    2196.77   0.11561842     119.82    1036.34   0.9563679     2320.99    2426.88   0.8267207     2233.08    2701.13   0.7774828      1432.1    1841.97   1.1833463

                       362.79   0.6291713      248.12     394.36    0.6009933     373.95     622.22   1.3083255      319.48     244.19    1.050133      599.92     571.28   1.4242253      303.36       213    1.1577922
                      1525.39   0.97448426    1070.89    1098.93      1.18955    4175.63    3510.26    0.4912895      763.4    1553.87    0.9618335    2002.72    2082.19   1.2331047      505.24     409.73   1.0288115
                      4769.65    1.0076873    1500.92    1489.47    0.5338545    1880.15    3521.84    1.2263536    1680.73    1370.51   0.84241873    2477.09    2940.45   0.7769736      1351.6    1739.57   0.9280002
www.molmed.org



                       232.31   0.91063136     117.69     129.24    2.0897048     416.52     199.32     2.672156     139.54      52.22    0.8479856     273.84     322.93   21.492754       148.3        6.9   1.0630119
                     60230.17    1.3372278   43127.27   32251.25     4.124263   108199.7   26234.92    1.8934398   32838.08   17343.08    1.6221883    59858.6   36899.91   1.6021719    18749.93   11702.82   1.1116568
                                0.35970223      82.62     229.69    0.6523259     546.61     837.94   0.57174444     224.97     393.48   0.78749275     368.46     467.89   0.9060744      167.66     185.04    1.644124
                      7856.97    0.9455693    6509.62    6884.34    2.7116477   14795.13    5456.14    1.0630546    5558.67    5228.96   0.82855314    6835.05    8249.38   1.0976552     5945.57    5416.61   1.3351355
                      9714.31    0.7599952    4716.88    6206.46    0.5042119    2663.56    5282.62    0.6692827    2789.51    4167.91     1.014275    8284.05    8167.46   0.3807059      930.43    2443.96   1.1390258

                      3583.02   1.0896356     5300.14    4864.14    0.9438595   10748.38   11387.69   0.7541237     1348.69    1788.42   0.92476946    1707.67    1846.59   1.0366156     1576.63    1520.94   0.8326515
                      4966.53   0.73385465    3018.08    4112.64    1.0006541    4115.18    4112.49    0.9995017    2948.42    2949.89    0.8217689    3579.42    4355.75   0.73889744     732.24     990.99   1.1058606
                     63874.96    1.0182548   65408.19   64235.59     1.049382    45334.5   43201.14   0.95549065   36873.75   38591.43   0.62055594   40000.75   64459.54    1.0738516   43984.63   40959.69     1.18547
                       365.84                                                                         0.95304215     145.52     152.69     0.660227     308.94     467.93                                      1.2059839
                      9617.48   0.56517875    2284.17     4041.5     0.159524     480.03    3009.14    0.8553249    4058.97    4745.53    0.9897451   12566.16   12696.36     0.677371     2463.7    3637.15   0.8654267
                      6963.95   0.49420398    2424.11    4905.08   0.45006156    1546.11    3435.33   0.62109715    6581.04   10595.83    1.8600328   17347.67    9326.54    0.4586157    1892.95    4127.53   0.7451677
                     16124.53     1.388398    6479.39    4666.81    3.3988955   13529.44    3980.54    1.3338071    1623.31    1217.05    2.0212946   18047.11    8928.49    1.3559477    5130.73    3783.87   1.5294619
                     36981.52    1.1316854   41011.44   36239.26   0.53870654   29120.31   54055.98   0.79954857   57682.81   72144.22   0.77904433   54458.65   69904.43    0.9922739   34939.96   35212.01   0.9115662
                      2668.98    1.1323731    4140.76    3656.71     4.552038   21809.18    4791.08    0.6450891    2698.04    4182.43   0.77072567    1744.26    2263.14    1.8445802    1395.72     756.66   1.2995428
                      7077.75     1.188169    9370.84    7886.79    1.1638802    9011.18    7742.36    1.2023668   10123.22    8419.41    0.5247715    3726.24    7100.69    0.7399762    2991.45    4042.63   0.8850462
                      9860.61    0.8164356    7258.88    8890.94    1.5190808   17077.02   11241.68    1.3083662    6640.39    5075.33   0.88940275    4238.28    4765.31   0.87956876     951.28    1081.53   0.9461459

                      1145.35   0.72423273      482.1     665.67    1.6363484    1656.41    1012.26   1.5098722     1361.18     901.52   1.3861157      518.13      373.8   0.7343664      534.09     727.28   0.9719749

                     12352.28    0.745151     7941.03   10656.94    1.2322826    9499.79     7709.1   0.88003415    8938.92   10157.47    1.118418    17558.85   15699.72   1.0104594     3787.01    3747.81   0.7054275

                     24227.82    0.536463    11241.19   20954.27   0.13933754    4091.97   29367.32   0.59464526    7374.88   12402.15   0.29275036   11862.28   40520.12   0.6194116     7783.52   12565.99   0.53910804
                      6639.94   2.7802632     9302.51    3345.91    0.9331351   10357.52    11099.7    0.6700722    2518.56    3758.64    0.6103805    3128.09    5124.82    1.5490644    2202.15     1421.6   1.7126346
                     13628.12   0.5813264     6795.88    11690.3   0.15403262    1877.65   12189.95    0.3534928    1729.29    4892.01    0.9081998    6926.54    7626.67    0.6079366    1327.15    2183.04   0.7862544
                     30053.84   0.9581473     8338.67    8702.91    1.9428308   14588.25    7508.76   0.84496605    6633.55    7850.67    0.6820108    4034.51    5915.61   0.94742286    6760.44    7135.61   0.9486849
                       424.48   0.9307798      190.27     204.42     2.059268     545.15     264.73                                      0.28224552     190.05     673.35

                       8032.4   0.69771796    10024.4   14367.41     0.504631    8186.26   16222.27   1.4765414    11587.72    7847.88   0.6720477     3429.93     5103.7   1.9266287     3543.86    1839.41   1.1343889
                        994.8    1.1261202     962.54     854.74     3.179618    2696.38     848.02   1.9858353      822.95     414.41   2.8241396      865.74     306.55    1.8439233     618.12     335.22    1.2806581
                       902.43     1.306528    1780.85    1363.04   0.45103762    5029.43    11150.8   0.7611767     3540.05    4650.76   0.7879286     1322.94    1679.01   0.85112333    2760.61    3243.49   0.90079176
Molecular Medicine




                      8264.45    1.1222612    6482.91    5776.65    4.4568524   17098.18    3836.38   2.7425442    10810.34    3941.72   2.5987623     7134.98    2745.53    1.7573044    3255.09    1852.32    1.1970425
                      4853.48   0.56339914    4415.68    7837.57   0.39444596    2105.86    5338.78   1.0624713     1224.19    1152.21   0.6807913     3952.79    5806.17    1.1009971    1433.19    1301.72   0.60177493

                      7438.48   1.0952239    10543.71    9626.99     2.885915   23213.81    8043.83   1.5365671     5285.99    3440.13   1.0097203     2368.38    2345.58    1.013065      865.35     854.19   0.76034725
                      5079.15     0.862753    4037.33    4679.59    1.7397754   15568.45    8948.54    0.5982446    1181.91    1975.63   0.74892867    2789.22    3724.28   0.24435368     238.13     974.53    0.6614181
                     59469.05   0.59672076   15327.53   25686.27    0.5740357    4868.42    8481.04   0.94179237    8553.66    9082.32      1.50842   71635.21   47490.23    1.0367566   17259.23   16647.33    1.2711444
                     18972.46    0.7540633    6205.76    8229.76    1.1736658     4479.8    3816.93   0.80327004    2745.85    3418.34   0.85985905   16904.58   19659.71   0.89853394    1920.23    2137.07     0.902106
                       417.31   0.49874648     103.45     207.42    3.0996494     645.44     208.23    1.4664232     429.53     292.91    2.4825866     472.61     190.37    1.4529496     309.58     213.07    1.6216663
                       515.82      0.53164     877.19    1649.97   0.37205654     954.18    2564.61   0.72834665     649.27     891.43    0.9442259    2429.04    2572.52    0.9330843     412.19     441.75    0.7561319
                     15985.65   0.85361147    8654.75   10138.98    1.0467037   13214.75   12625.11   0.90347725    4128.24    4569.28   0.41549796    6824.23   16424.22    0.9553164    4846.11    5072.78   0.74805075
                      5082.35     0.873187    3948.56    4522.01    3.5337842    28709.1    8124.18    1.4352986    5936.28    4135.92    1.9604257    6938.77    3539.42    0.7705986     903.55    1172.53    1.3359416

                      4197.16   1.1035169     2657.71     2408.4   0.49993244    1442.37    2885.13   0.8378848     2422.04    2890.66   0.7638944     3037.03    3975.72   0.7178594     1982.62    2761.85   0.9048284

                       336.98    0.650038       513.4      789.8   0.34913692     574.62    1645.83   1.0448971      579.27     554.38   1.1460255      362.74     316.52   1.1971246      497.92     415.93   0.9465785

                     13085.08   0.63797534     5686.3    8913.04   0.40346527    2528.88     6267.9   0.79004216    2232.13    2825.33   0.71848375    8799.81   12247.75   0.79319876    1824.96    2300.76   1.0091842
                     14037.27   1.0499557      2244.9    2138.09   0.58875865    5190.52    8816.04   1.8502631     6428.11    3474.16   1.8809353    11364.31    6041.84   0.7823722     4421.96    5651.99   0.9024492




                                                                                                                                                                                                                       UNCORRECTED PROOF
                     16742.63   0.8121907     8579.82    10563.8   0.3445942     2817.12    8175.18    1.471981     3670.62    2493.66   1.3005456    15935.56   12252.98    1.3644028    4999.39    3664.16   1.0811044
                       489.55   1.6151834      296.37     183.49   1.0881103     1011.91     929.97    0.906444      367.98     405.96   2.2141275     1019.96     460.66   0.25463977      76.56     300.66   1.2140889
                      1540.38   0.9970033      475.77      477.2   0.6828354     1478.68     2165.5   1.0161077      490.78       483    1.0557171      853.22     808.19    1.0154531     246.42     242.67   1.5684028

                       964.32   1.0047475     1991.52    1982.11   0.56905764    1371.85    2410.74   1.1346104     1257.33    1108.16   0.95831954     581.01     606.28   1.1955785     1136.23     950.36   0.9434187
                      7252.59   0.8970644     1985.06    2212.84    1.4449975    3518.28     2434.8   1.1042625     2724.58    2467.33   0.9876075     6021.66    6097.22   1.0338305     2313.63    2237.92   1.0304067
www.molmed.org



                       721.17   1.0422877     1186.78    1138.63   0.85952914    1803.06    2097.73   1.3976074      772.29     552.58   1.2412143     1688.25    1360.16   1.5190101      440.68     290.11    1.051905

                      4369.24   1.2401038      2918.2    2353.19   2.4386547    11495.11    4713.71    1.106616     2692.74    2433.31   1.0124024     3510.89    3467.88   1.1034634     3279.46    2971.97   1.1858613
                      1802.07   0.98509866    1125.16    1142.18    0.5952931     824.35    1384.78   1.2003232      720.53     600.28   0.71625394    1464.46    2044.61   1.0983726      814.63     741.67   1.0508463
                                  1.183003     447.53      378.3   0.89690715    1886.68    2103.54   1.0562414      576.75     546.04                                      2.0932858       704.6      336.6   0.8745206

                      1039.74   1.1318089     1704.64    1506.12    0.691396     2569.11    3715.83   0.82613945     451.89     546.99   0.46263787     425.34     919.38    1.106486      744.82     673.14   0.7405412
                      1189.41    1.694729     1049.41     619.22    1.4480903    1846.46     1275.1   2.1034992      242.26     115.17    0.5293433     359.53      679.2                                      1.4084669
                      3887.61    1.515595     3090.48    2039.12    1.5222497    8234.32    5409.31   0.7500359     2558.65    3411.37     1.052122    4002.23    3803.96    1.2526181    3314.39    2645.97    1.675462
                     13192.29   1.0789777    16750.59    15524.5    1.5948883   39907.98   25022.43    0.915698    15201.74   16601.26   0.64791036   15138.27   23364.76   0.83012724    9605.51   11571.13   0.9058542
                      6085.59   0.7911565     2201.82    2783.04   0.43292028    1618.23    3737.94   1.2723941     4945.91    3887.09    0.5994767    2389.55    3986.06    1.5562631    3257.99    2093.47   1.2518358

                      3070.35   0.6973795     5123.55    7346.86   0.31902263    2694.87    8447.27   1.5493993    20558.19   13268.49   1.8760996     7151.56    3811.93   1.2885606     2709.83    2102.99   1.1927192


                      1161.49   3.2401414      448.63     138.46   0.12382402     445.92    3601.24   0.22705649      97.85     430.95   0.5671923     2038.75    3594.46   0.60813946     178.27     293.14   0.10492658
                     11401.78   0.9912398     3963.74    3998.77    2.113164     9629.54    4556.93   1.6239847     2603.15    1602.94   0.79332536    4285.52    5401.97    3.025879     2059.08     680.49   1.8364521

                     28368.41   0.8761322    22318.54   25473.94   1.4668103    52954.07   36101.51   1.0443044    19984.77   19136.92   1.4580725     39424.3   27038.64   1.5615579    25279.17   16188.43    0.955468
                                0.6928023      372.79     538.09   0.89699817      888.1     990.08   2.2629251       163.7      72.34   0.9503369      444.33     467.55                                      0.8771152

                      3928.99    1.687888      5619.3    3329.19    4.765335    20537.64     4309.8   1.1181409     3378.15    3021.22   1.3138071     2695.84    2051.93   1.2631651     3630.16    2873.86   1.1923125
                     41212.42   1.4525806    42881.08   29520.62   1.7311094    71166.46   41110.32   0.9995457     8031.07    8034.72   1.4509736     5449.03    3755.43   1.1177657     5128.89    4588.52   0.9114622

                     31068.86   0.6367032     5561.73     8735.2   0.37379023    3586.17    9594.07    1.226748     1262.25    1028.94    1.765134    22995.62   13027.69   1.3236538      1236.2     933.93   1.1175054
                                1.3336698      171.75     128.78    1.025989       355.3      346.3    1.4407542     314.07     217.99   0.49252704      64.59     131.14   2.1185665      189.76      89.57    1.0281593
                      1401.18   1.7103558      670.22     391.86                                      0.49464214     163.87     331.29    0.7718953    1713.87    2220.34    2.045334      293.26     143.38   0.42916986

                     71516.99   0.9398855     39301.5    41815.2   0.44404772   19408.07   43707.17   0.7968957     6600.83    8283.18   1.6493992    31367.12    19017.3   0.8588479     6831.07    7953.76   1.2322332

                      2744.67   0.79212946     2468.6    3116.41   0.7659027      2839.5    3707.39   1.0693243     2342.59    2190.72   0.94396764    3539.52    3749.62     0.98279     1893.05     1926.2   0.9105793
                     29570.89   0.77471626    8894.13    11480.5    0.5373742    4185.93     7789.6    0.9460811    3675.44    3884.91    0.8852084   13984.93   15798.46   0.93632275      4362     4658.65    1.1291991
Molecular Medicine




                      6747.56    0.9659411    1554.46    1609.27    1.0641749    4873.74    4579.83    1.5262445     5278.7    3458.62   0.48908848    1305.92    2670.11   0.79301023    1214.63    1531.67    0.9983138
                       976.12                                        4.046781     101.21      25.01   0.48157614     339.15     704.25    0.6723201     966.44    1437.47   0.67627794     343.84     508.43    1.7548434
                     23519.35   1.1999081     7362.66    6136.02     3.798473   29356.08    7728.39    1.0828931    3911.67    3612.24    1.0725309   21849.48   20371.89    1.0160594    3732.22    3673.23    1.0438741
                                1.1627715      590.56     507.89    0.8771873    4747.11    5411.74    1.3141729    1017.38     774.16    2.3412454     295.91     126.39    0.7378374     220.06     298.25   0.89798015
                     14558.25   0.8985662     9907.86    11026.3     0.957283    24779.1   25884.82    1.2968106   12962.79     9995.9    1.1823415   14835.56   12547.61        1.258    3986.64    3169.03    1.2460108
                       343.63   1.2133542      177.72     146.47    1.2894876     659.07     511.11    1.2221198     305.09     249.64    0.8783485      457.4     520.75   0.92147285     316.83     343.83     1.005171
                      5833.62   1.2565727     5504.58    4380.63    1.1396353     9710.9    8521.06    1.2377119    3893.73    3145.91    1.3131126    5570.71    4242.37    1.2697455    4289.34    3378.11   0.96453226
                       211.81   1.0318261     1401.22      1358     1.3800807    2568.91    1861.42    1.3861797    1306.71     942.67    0.7263668     309.04     425.46    1.0655444     667.18     626.14    1.0220954
                      4287.78    1.355479     4211.88     3107.3    0.7270675    8776.01   12070.42    0.5942964    3396.57    5715.28    0.6186405    2872.49    4643.23   0.63608676    2272.28    3572.28   0.78686124
                       742.43   1.6426497      933.14     568.07    1.6119351    5146.78    3192.92    1.0151778     719.69     708.93   0.97190344    1339.73    1378.46    1.4743934     904.85     613.71    1.0260209
                        498.5    2.385828      281.48     117.98   0.67925525    1198.05    1763.77    0.9902712     426.49     430.68    1.0905998     907.27      831.9    0.7745211     214.31      276.7    1.0882742
                      3683.84   1.2888935     3542.64    2748.59    1.3562388    9403.78    6933.72    1.0535995    3035.03    2880.63    1.3918227    4334.08    3113.96    1.0399123    1619.83    1557.66   0.97645795
                      4999.99   1.4232411     2295.09    1612.58    1.1776325    4338.81    3684.35    1.2447174    1727.73    1388.05   0.81117404    3206.79    3953.27    0.9022872    1385.85    1535.93    1.0002716
                      2209.67   1.0695745      1990.2    1860.74    1.0535257    5363.12    5090.64    1.3090181    1961.59    1498.52    0.8344482    2146.71    2572.61       1.1431    1486.11    1300.07   0.88526285
                     63874.96   1.2408975    39463.41   31802.31    0.3715973   19407.52   52227.29    1.0062469    31743.6   31546.53    0.6856352   29671.39   43275.77    0.6858685   27766.55   40483.78   0.51824564
                      3395.53   1.6282218     3912.91    2403.18    3.0868816   13079.24    4237.04    0.7762598    4946.04    6371.63    1.1802435    5844.99    4952.36      0.95534    4174.75    4369.91    0.9314134
                     24689.76   1.2053158   29045.87   24098.14   0.9333262    13096.05    14031.59   0.7943173   18199.66   22912.33   0.6976431   14800.08   21214.4     0.6532303    11628.46   17801.47 0.73924154




                                                                                                                                                                                                                    UNCORRECTED PROOF
                     98201.3    1.0862268   28400.67   26146.17   1.8019482     73304.5    40680.69   1.382515    18035.97   13045.77   1.7760494   35341.43   19898.9     0.8580254    13888.96   16187.12   0.8230304
                      2463.9    0.8985724   2405.64    2677.18    1.8275537    11935.06    6530.62    1.1213584   2812.21    2507.86    0.9526686   2954.94    3101.75     0.7937287     423.74     533.86    1.1437771

                         8.9                                                                          2.1079295    133.98      63.56    1.7384582    536.21     308.44

                     9278.53 0.63206655     3387.51    5359.42 0.76979667       2107.18    2737.32    0.7590207      581      765.46    1.7535335   5458.89    3113.08     0.8574419     856.13     998.47    1.1389976
www.molmed.org




                     17325.49   1.5353082   4892.26     3186.5    1.7318256     8338.81    4815.04    1.4081826    3440.5    2443.22    1.0476784   8611.78    8219.87 0.93116695       1848.86    1985.53    1.149425
                     6008.52    1.0104768   3854.07    3814.11 0.61941636       3690.65    5958.27    0.8314844   7600.05    9140.34    2.4698987   28467.19   11525.65 0.76597977      3501.24    4570.93    2.2171805
                     4474.82 0.80171025     2429.15    3029.96 0.19774635        871.13    4405.29 0.93612117     3894.76    4160.53 0.96631163     4842.68    5011.51 0.84030026       2784.36    3313.53    0.8332528
                     3255.34 0.85242945      496.31     582.23 0.20845057        163.74     785.51    1.5257835   1492.14     977.95    1.6902341   2303.13    1362.61      1.168726    1635.41    1399.31    1.037838
                     2717.23 0.98069525     2979.47    3038.12    0.7700725     5025.94    6526.58 0.95372474     3532.52    3703.92    0.799641    2405.92    3008.75     1.0830551    2089.17    1928.96 0.95580477
                      159.44                                      0.8288124      643.78     776.75 0.37825397      202.99     536.65    3.998239      272.4      68.13     0.7634439     244.47     320.22 0.65040314
                      544.03    1.1177802    444.15     397.35 0.53772646        195.27     363.14    0.9133254    1015.7    1112.09    2.1270425    643.09     302.34     1.5709106     740.81     471.58    1.3860401
                     13678.6    1.5458156   8789.09    5685.73    5.4807673    40602.23    7408.13    0.9993217   7763.95    7769.22    1.3293215   19133.96   14393.78    1.1785034    7790.98    6610.91 0.89175117
                     3025.84    1.126674    3297.11    2926.41    3.0318382     9017.99    2974.43    1.0538113   2961.41    2810.19    0.5170397   1599.24    3093.07     1.1177943    1871.78    1674.53    0.9696492

                     1577.07    1.0090953   2069.14    2050.49    2.6742842      7681.4    2872.32    0.9469445   1087.31    1148.23    1.1222061   1463.02     1303.7     0.7628422    1257.53    1648.48    1.1116375

                     12210.14   0.8398776   6549.08    7797.66 0.81313086       3167.47     3895.4    0.7424544   6623.45    8921.02    1.0088483   14278.1    14152.87    1.1543713    4400.74    3812.24    0.9501699

                     5428.77    1.4593602   5203.32    3565.48    7.1472497    23550.83    3295.09    1.651897    2320.37    1404.67    2.0781739   6639.35     3194.8     2.4689696    4615.22    1869.29    1.3088387

                     27288.26   1.9107903   31877.83   16683.06    9.278636    223595.23   24097.86   1.1964852   7261.11     6068.7    1.7943432   18462.68   10289.38    2.0238814    11039.08   5454.41    1.1674076
                     33029.27   1.8048419   31288.9    17336.09   4.8254247    83172.71    17236.35   1.3396693   28996.86   21644.79   0.6724971   15679.6    23315.49    0.9175309    16215.45   17672.92   1.1731461
                     30737.22   2.026209    8919.21    4401.92    1.8622099      7418.3     3983.6    1.6089994   3182.44     1977.9    2.1673496   3893.86     1796.6     1.8416824    2154.75    1169.99    1.430403

                     10275.39   1.9148902   6290.07    3284.82    5.0633206    12065.64    2382.95    1.5822659   2401.12    1517.52    1.9916445   17081.26   8576.46     1.7956632     1157.7     644.72    1.0928606

                     10453.94   1.2152672   9655.93    7945.52    1.7842481     8128.82    4555.88    1.1908967   1344.07    1128.62    2.1283948   3994.38    1876.71     1.8049859     997.02     552.37    1.0956647

                     20184.05   1.6288302   8413.56     5165.4     5.226973    32856.96    6286.04    1.3278823   5342.23    4023.12    1.3441548   9461.21    7038.78     1.1197176      2722     2430.97    1.3396934

                                                                                                                                                                          0.022297269     11.29     506.34
Molecular Medicine




                     18667.7    3.0292132   21135.91   6977.36    14.543669    123134.11   8466.51    3.3540561   10418.47   3106.23    6.6121097   13268.19   2006.65     3.1763098    9823.66    3092.79    1.5974803
                     15235.11   1.5327073   24325.72   15871.08   3.8436382    47724.65    12416.53   1.3259933   14624.34   11028.97   1.532059    6685.43    4363.69     1.0113198    11374.95   11247.63   0.8884928
                     6839.17    1.9579422   10906.11   5570.19     4.094642    27844.18    6800.15    1.2221093   5497.28    4498.19    1.3304255   3876.78    2913.94     1.1632555     4765.8    4096.95    1.0188522
                     57472.01   3.5856667   19157.32   5342.75    11.995286    100761.84   8400.12    5.195591    11439.6    2201.79    8.569722    67702.01   7900.14     4.0370793    12308.65    3048.9    1.6019773
                      2670.3    1.6691657    805.94     482.84     3.563179     5820.56    1633.53    1.2390864    2083.4     1681.4    0.9913492   2765.22    2789.35     1.4846267    2068.07    1392.99    0.9269729
                                1.080177     583.49     540.18    1.9071271     1575.02     825.86 0.94553024      751.81     795.12    1.1750612    239.83      204.1     0.6782417     249.81     368.32 0.91370636
                     1923.15    0.6217564   2407.08    3871.42 0.44731182       1635.43    3656.13 0.83556277     1997.63    2390.76    0.8474107   1509.23    1780.99     0.8328728     717.37     861.32    1.1083227
                      8556.7    1.1818616   8623.17    7296.26    0.3418664      5810.2    16995.53   0.9587171   1977.68    2062.84    0.8764299   2635.53    3007.12 0.77028644       2785.04    3615.59    0.7319677
                     7408.43    1.5697976   12466.25   7941.31    4.0339093    48738.34    12082.16   0.6050658   3150.36    5206.64    0.882904    3778.52    4279.65     0.5978028     2791.5     4669.6    0.8703948

                     48107.41   0.7839333   33207.03   42359.51 0.86100346     18742.29    21767.96   0.5275628     15751    29856.16 0.31171748    21783.91   69883.51    0.8131743    18286.86   22488.24   0.7438434
                     1114.77    0.5243945     601.9     1147.8    0.35180023     599.45    1703.95    1.2646905    338.33     267.52 0.42624277      860.03     2017.7     0.5964763     224.46     376.31 0.88592035
                      3023.9    0.8117833    2193.26    2701.78 0.33740854      2918.81    8650.67    1.0707508     1511.14    1411.29    1.8359092    3716.67    2024.43    1.2205974     942.35     772.04    1.0257783




                                                                                                                                                                                                                      UNCORRECTED PROOF
                     19764.72   0.6680851    9200.44    13771.36 0.61431146     5707.82    9291.41 0.68885726       2580.48    3746.03    1.1615225    27630.6    23788.26   0.6466811    6581.17    10176.84   1.052579
                     22823.82   0.8255126   10111.91    12249.25 0.67558163     8945.66    13241.42 0.38678637      3187.99    8242.25    0.6051413    11574.9    19127.6 0.76095456      4696.33    6171.63    0.8102208
                      285.14    1.110538      512.38     461.38    2.0086782       537      267.34    1.4120176      279.17     197.71    0.7370625      260.5     353.43                                       1.4520861
                      656.14    1.0109699     1101.3    1089.35    1.1251551    2148.72    1909.71    0.7390184      935.08     1265.3    0.7957401    1217.18    1529.62    0.6088981     662.95    1088.77    1.4265393
                      693.44    1.1586338     387.76     334.67    1.1802306     763.68     647.06    1.8189418      450.37      247.6    1.4417274     886.72     615.04    1.4151692     335.48     237.06    1.2659765
www.molmed.org




                     1275.49    0.9225262    1535.96    1664.95    1.4366608    2497.29    1738.26    0.9740392      344.43     353.61    0.7119568     734.12    1031.13 0.25796288       133.47      517.4    0.8461698
                     5688.17    0.5732659    2381.96    4155.07    1.1259718    5851.72    5197.04    1.0451336     2262.85    2165.13    0.6876116     1671.9    2431.46 0.33863693       231.99     685.07    1.1009868
                                1.8197904      133.7      73.47    1.7067044    12481.59   7313.27 0.67511284        143.61     212.72     0.080147       9.16     114.29    1.2402481      69.95       56.4    1.004381
                     2018.86    1.1387262    4663.46    4095.33    1.5431823    11042.92   7155.94    0.9820753     3457.18    3520.28 0.90071577      2312.93    2567.88    1.2508445     1073.9     858.54 0.93042517
                      7121.5    0.8385931     2581.5    3078.37 0.46321407      1413.28    3051.03    0.9907667     3287.77    3318.41    1.1398243    5991.84    5256.81    0.9674088    4602.66    4757.72 0.98536325

                      6667.8    1.2378587    2933.23     2369.6    0.8009206    1780.03    2222.48    0.9165507     1040.56     1135.3    1.3911017    5525.79    3972.24    1.6024555     459.44     286.71    1.5060549

                     14272.05   0.6882457    9311.71    13529.63   0.6775596    19415.2    28654.6     1.421362     6454.59    4541.13    0.9207495    5064.49     5500.4 0.97243655      1511.39    1554.23    1.0256724

                     2610.35    1.7908762    2952.51    1648.64     2.518969     8243.1    3272.41 0.90905046       3763.16    4139.66    1.1404326     5195.8    4555.99     1.061959    3924.82    3695.83    1.0637336
                     11948.43   1.0241942    6007.37    5865.46 0.13693084        453.2     3309.7    1.0812417     8922.45    8252.04    1.9549378    30113.49   15403.81   1.1239794    2563.37    2280.62    1.1275871
                     1829.98    0.8686024    1582.22    1821.57 0.56501913      1636.77    2896.84    0.9867025     1228.78    1245.34 0.73466915      1940.68    2641.57    1.4769264    1529.18    1035.38    1.1316241
                      462.31    1.1666348    1094.56     938.22    0.8091218     6336.2    7830.96    0.8218839      286.18      348.2    0.37000576    192.81      521.1    0.70968264    174.22     245.49    0.9575477
                     63874.96   1.3821325   43791.06    31683.69   0.7235519    26395.97   36481.1    0.7990484    11937.56    14939.72   1.7897402    86764.88   48479.04     1.19559    21095.11   17644.1    1.0194985
                                                                   0.39997545    228.27     570.71
                     4821.96 0.99210244      6009.78    6057.62 0.35512257       5046.8    14211.43   1.3974161     9052.07    6477.72    1.0668478    5797.24    5433.99    1.0744883    5282.99    4916.75    1.4265808
                     4741.54    0.7334627    2377.16    3241.01 0.59251565      2264.34    3821.57 0.87203693       1704.37    1954.47    0.5608059    4595.76    8194.92 0.83441323      2803.62    3359.99    0.824519
                     3773.01    0.6007189    1504.05    2503.75 0.24485266      1020.23    4166.71    1.0909884     1828.06     1675.6    0.5215386    1241.94     2381.3    0.3310181      303.1     915.66    0.7364404
                     26751.51   1.0251453   14161.48    13814.12   3.4466367    51294.74   14882.55 0.89231414      4255.33    4768.87    0.7165347    12940.81   18060.27    0.920387    3224.99    3503.95    0.8947971
                      635.49    0.9981939    1558.53    1561.35    1.1197269    3726.16    3327.74     1.208804      671.95     555.88    0.8352172     478.83      573.3    1.7563559     618.29     352.03 0.81017655
                     1474.36 0.90545654      2799.11    3091.38 0.89671963      14208.19   15844.63 0.77561843      1431.59    1845.74    1.2459654    2534.58    2034.23 0.46118718         70.7      153.3    0.8511144
                     1618.17 0.62383175        614.1      984.4    0.6251892    1012.05    1618.79    0.7200616      762.43    1058.84    0.7761189    1914.01    2466.13 0.80279255       528.39     658.19    0.8993989
Molecular Medicine




                     21713.84   1.0012796    16706.1    16684.75    2.029323    34735.52   17116.8    0.9771239    11020.57    11278.58     1.15993    19871.11   17131.3    1.0349023    8965.09    8662.74    0.9971066
                                0.7491073     409.11     546.13    2.5093079      997.5     397.52    1.1247396      610.07     542.41    2.0639365     307.96     149.21    0.6250044     175.92     281.47    1.1896329
                     63874.96   1.4315232   28949.75    20223.04   1.5935266    34924.7    21916.61   1.3768159    42175.41    30632.57   1.3634043    53861.33   39505.03   1.8152728    28584.43   15746.63 0.85773736
                     40013.1    1.4942969   22384.24    14979.78 0.48103008     12014.38   24976.36    1.303243    12654.96    9710.36     1.086853    40258.11   37040.99 0.88991433     15265.52   17153.92   1.5657479
                     12255.87   0.920995    16796.62    18237.47 0.71627474     14249.85   19894.39   1.0201443     9227.44    9045.23 0.59935546      5493.65    9165.93    1.0293002    6429.04    6246.03    0.9498649
                     11420.9    1.1520857     8497.3    7375.58 0.80065286      14308.69   17871.28   0.8466906     7639.24    9022.47    1.0442642    14849.05   14219.63 0.74159944     3977.45    5363.34    0.8241547
                     1936.26    0.7416232    1054.44     1421.8    1.8510399    3735.38    2017.99    0.9073494     2308.07    2543.75    0.6284781     594.49     945.92    1.1585683     697.91     602.39    1.2718004
                      559.24                                                                          0.24242215      34.95     144.17    2.5322545       895      353.44                                       10.297448
                     3046.71    1.7123045    4136.14    2415.54      2.12733    8279.42    3891.93 0.84136844       2180.12    2591.16 0.94759536      2695.34     2844.4 0.76086766      1229.76    1616.26    1.0321295
                     3437.38    0.9347223    1208.68    1293.09      0.46765    1859.83    3976.97    1.7649021     2930.02    1660.16    2.3384428    1905.41     814.82 0.69916385       505.88     723.55    1.4433721
                     63874.96   1.7344116   111410.95   64235.59   5.3389163    343389.9   64318.28    3.308534    168414.55   50903.07    4.524105    276940.9   61214.52   1.1900342    46255.26   38868.85   1.7914093
                     51112.32 0.98728913    19907.48    20163.78   1.6166887    12418.61   7681.51    1.8838925     7725.73    4100.94    1.2100786    32975.27   27250.52   3.4615142    10476.48   3026.56    1.2761884
                     63874.96   1.051407    33003.15   31389.51   1.9356169    98264.01   50766.25    0.524114    18801.12   35872.19   1.0909419    54365.37   49833.42   0.5201841   17037.44   32752.71   0.5652061




                                                                                                                                                                                                                   UNCORRECTED PROOF
                      365.62 0.85459775       62.36      72.97    0.8978547     871.35     970.48    0.7380036     755.14    1023.22    0.9587666    1163.77    1213.82 0.47873643      367.21     767.04    0.6523831

                     6231.86    1.7949524   12524.37   6977.55      3.61332    35734.04   9889.53     0.657928    4092.97      6221     0.91565835   3694.37    4034.66 0.71017534     4609.62    6490.82    1.0993509

                     22136.02   1.4200133   18159.23   12788.07   3.8672512    35525.96   9186.36    1.5586705    14194.11   9106.55     1.259937    10825.29   8591.93    0.6890946   5962.06    8652.02    0.8689161
                     8420.28    0.8741947   6729.83    7698.32    0.7789261    10173.74   13061.24 0.85765266     8620.85    10051.68    1.273361      15992    12558.89 0.71960723    3691.29    5129.59 0.79548347
www.molmed.org




                      403.87    1.3948357    230.12     164.98    1.1221023     324.31     289.02                                       1.2214469      498.9     408.45
                     13444.21   1.3722177   1402.53    1022.09    0.9504116    6526.61    6867.14    0.5129593    1966.65    3833.93    1.0565922    16896.41   15991.42   0.5883158    378.54     643.43    0.7354422

                      463.23    1.0790461    379.63     351.82     1.122084     896.59     799.04     1.116448      190.6     170.72    1.8027408     136.81      75.89                                      1.2983509

                                0.9433599     834.6     884.71    1.1751497    1506.06    1281.59    0.9652366     629.73     652.41    0.1323043     127.97     967.24 0.34813425      172.41     495.24    1.5197543
                     5230.23    1.4326174   7049.18    4920.49    1.1671464    27557.05   23610.62   0.8521912    1456.48     1709.1    1.3885905    1846.02    1329.42    1.6725554   1731.63    1035.32 0.86432606
                     1859.13    0.8949793   2311.83    2583.11    0.8553183    5189.31    6067.11 0.93754345      1453.83    1550.68    0.7539672     996.79    1322.06    1.2787739   1410.04    1102.65 0.99386257
                      249.47    1.8665493    254.56     136.38 0.63861746       574.43     899.49    0.5845363       132      225.82    0.4924867     264.16     536.38    1.5153266    401.41      264.9    213.9615
                      585.19 0.54778355      127.65     233.03    1.3552762     720.37     531.53 0.80379575        387.1     481.59    1.4386493      544.5     378.48    0.5078875    166.13      327.1    1.0986003
                     27623.84   0.7848755   7694.19    9803.07    0.5408459    3663.23    6773.15    0.9064018    2253.75    2486.48    1.0103804    18407.08   18217.97   1.1894292   1769.49    1487.68 0.97606266
                                                                                                                                        0.56538844     96.28     170.29
                        5.98                                                                         0.7703442     363.51     471.88 0.69228184       371.34      536.4    1.6132144    464.88     288.17
                      588.11    2.5412955    319.39     125.68    1.5299332    1978.02    1292.88    0.6336715     238.59     376.52    1.5879694     643.35     405.14    1.6570858    332.08      200.4     1.00905
                                1.0925384   1364.22    1248.67    0.8301947    21193.41   25528.24   1.1952678    1071.45     896.41    1.5347837     895.27     583.32 0.57195014      197.38      345.1    0.8187683
                     4352.15 0.98332375      1761.3    1791.17 0.19606125       349.54    1782.81 0.33714077      3807.59    11293.77   0.4755235    7347.87    15452.17 0.76816994     929.67    1210.24    0.7074065
                      378.93    9.310637     231.09      24.82    1.8410823      96.62      52.48    0.74275017    761.98    1025.89    0.7793178     904.71     1160.9    1.6048124    358.82     223.59    0.6430251

                      406.72    1.1282591    568.18     503.59    1.5744226     846.63     537.74    1.0239894     562.59     549.41 0.74361706       307.27     413.21                                      1.2253768
                      250.48    12.45117      90.52       7.27                                       0.5874064     259.71     442.13      1.16029      715.4     616.57    0.8046442    306.32     380.69    0.7065319
                       98.82                                      1.9427403     309.09      159.1    1.1139019     178.28     160.05    3.6125126     247.71      68.57                                      1.0535023
                     10599.68 0.82625705    10956.4    13260.28   0.6235846    15875.33   25458.18   0.9878435    13549.36   13716.1    1.0286151    11251.97   10938.95   1.133337    6217.94     5486.4 0.99527633
                      857.56    1.9949594    182.06      91.26    0.48589078    231.25     475.93    0.4414172     203.33     460.63 0.97142524      1099.09    1131.42 0.39080057       246.9     631.78 0.79554886
Molecular Medicine




                      2840.4    1.1551816   4000.14    3462.78 0.84104055      5319.27    6324.63 0.71037096      5261.81    7407.13    0.8531672    5513.96    6462.93 0.70981467     3693.62    5203.64 0.91554457
                     1183.67    1.2071977   1425.64    1180.95    1.1921791    2274.94    1908.22 0.70401436      1219.55    1732.28    1.0886563    1497.24    1375.31    0.9300793   1248.65    1342.52    0.8644869
                     2314.37    1.5540226   2117.48    1362.58    0.9490025     6823.1    7189.76    0.6255279     670.96    1072.63    1.3117664    3425.35    2611.25 0.92032045      652.36     708.84    1.0896558
                      3412.8    2.541973    4945.18    1945.41    2.6272817    10826.24    4120.7      0.45161    3683.06     8155.4    1.2203506    9627.81    7889.38    1.1284677   2462.17    2181.87    1.4657325

                     1088.59    0.909535     990.52    1089.04     0.577943    1010.99    1749.29 0.67742217       455.58     672.52    1.1656798     598.46      513.4                                      1.1341484

                     2256.94    1.4872339   2066.69    1389.62     3.726956    11744.98   3151.36    0.6248993     356.88      571.1    0.82677525    887.32    1073.23    1.3121761    496.37     378.28    1.1822826
                     3620.42    0.6936549   1335.91     1925.9    1.3407365    4590.99    3424.23    1.0966426    3364.05    3067.59 0.81957906      6036.47    7365.33 0.85936284     2097.55    2440.82    1.3163489
                     10368.41   1.3551962   12603.69   9300.27    2.2005763    34907.17   15862.74   0.6822724    8928.64    13086.62 0.87669796     10550.85   12034.76 0.71478444    3468.22    4852.12    0.8412294

                     49655.91   1.0608318   14139.18   13328.39   1.1279066    11574.51   10261.94   1.0819219    10312.49   9531.64     1.470018    37551.86   25545.17   1.1062247   16093.39   14548.03 0.87622905
                     5722.15    1.4069363   7608.05    5407.53 0.42485353      1749.36    4117.56    0.9996523     4629.1    4630.71 0.57958406      2897.59    4999.43 0.87793297     2170.54    2472.33 0.64524907
                     4365.33    1.3592607   3724.85    2740.35    3.8628132    47272.68   12237.89   0.9234036    6944.66    7520.72    1.2865218    4592.51    3569.71     0.72716    2245.39    3087.89    1.1228116
                     25063.42   1.0136223     10196.3    10059.27   1.1458974     8304.88    7247.49    1.0371637     3119.27     3007.5 0.87226504     14146.77    16218.43   1.532611     5445.29    3552.95    1.1645564




                                                                                                                                                                                                                         UNCORRECTED PROOF
                       32.14    0.03215403       3.29     102.32                                         9.054431       71.53        7.9    4.195234      301.05      71.76
                     61902.62   2.3919706    21479.06    8979.65    12.935089    80261.18    6204.92    2.6251512      6538.7    2490.79    3.8152323   24424.85    6401.93    3.5783093   10355.52    2893.97    1.9693987

                     4986.74 0.71552914       2263.14    3162.89 0.107665874       721.51    6701.38 0.77207166       4022.81    5210.41 0.94625014      3714.24    3925.22    0.8979549     5172.4     5760.2 0.89304537
                                1.2347705      303.84     246.07    1.8820393     2422.26    1287.04    2.2340508      230.42     103.14 0.16456129       212.08    1288.76    4.083322       286.2      70.09    1.2866523
                      372.19    1.0435882      508.05     486.83    1.2955626       526.4     406.31     1.186135      152.62     128.67    3.650189     1119.44     306.68    2.488714      426.69     171.45    1.5251139
www.molmed.org




                     25799.41   1.0121154     9019.86    8911.89    1.6293641    29126.22    17875.82    1.184589    10036.62    8472.66    0.879843    13409.67    15240.98   1.3564749   18003.61    13272.35 0.96520823
                     1841.45    1.4403743     5097.96    3539.33    0.7464274     9720.12    13022.19   1.0171547     2974.13    2923.97 0.88123316      2141.37    2429.97 0.95534164      1733.84    1814.89    1.0983882
                     1509.45    1.1880049     1189.87    1001.57    1.1805546     2446.05    2071.95    1.1900198      1005.9     845.28    0.6456755     495.02     766.67 0.43185353        97.18     225.03    1.0747694
                      336.12    0.7188045      474.26     659.79         0.01       15.77    2086.87    1.3512286      261.76     193.72 0.87491184       608.23     695.19 0.40453184        24.28      60.02    0.87399143
                     6139.43    1.1433802     7704.53    6738.38    2.0078537    13718.66     6832.5    0.6618017      423.52     639.95    0.5678273    1059.35    1865.62    1.1019211     730.21     662.67 0.96999633
                      209.41    0.9692288      229.62     236.91    0.5499621      312.12     567.53 0.52672964        146.71     278.53 0.83243954       448.61     538.91 0.97456944       193.53     198.58 0.20299192
                      554.31                                                                            0.18764581       18.5      98.59    0.5897646     416.94     706.96

                      762.92    1.0493025     2013.58    1918.97    0.7484525     3228.42    4313.46    1.3167609     1576.65    1197.37    2.6725335    2179.05     815.35    1.5794153    1459.98     924.38    1.0594695
                     10893.21    1.584987    12670.45    7994.04    1.9821049    25745.86    12989.15 0.88500756     10559.91      11932    0.9703751    8971.69    9245.59    0.9674203    6851.59    7082.33    0.8423032
                     60604.91   0.8556673    44046.88    51476.64   0.9095387    47424.51    52141.28   1.1462128    74085.47      64635    1.2585254   66891.48    53150.68   1.1780843   55325.43    46962.2    1.3523563
                     6305.47    1.2717344    12701.79    9987.77    1.1064129    31884.42    28817.83   1.1982324    16292.15    13596.82   1.0057203     6976.4    6936.72    1.0690649   13061.61    12217.79   1.1176788
                     8807.91    0.6033183     1742.54    2888.26 0.47404787       1594.55    3363.69    1.2274599     1454.27    1184.78    1.1230408    2955.54    2631.73 0.91510016       844.61     922.97    1.1356318
                      325.96    0.6820167      157.73     231.27    0.9501435      734.48     773.02 0.98646617        340.39     345.06    1.1002747     456.68     415.06 0.84495795       177.72     210.33 0.40066907

                     64653.24   1.1876467    52537.94    44237.01   1.7104231    82662.74    48328.83   0.7631552    30681.61    40203.63   1.9104215   48447.64    25359.66   1.1843772   21179.72    17882.58   1.3525835
                     1470.14    0.8177512     2731.06    3339.72 0.64271706       3209.71    4993.97    1.0513704      1579.4    1502.23    0.7496502    2673.32    3566.09 0.86083657      1572.12    1826.27    0.9795514
                      837.09     0.897614      957.44    1066.65 0.82163274       2228.72    2712.55 0.78187776        539.05     689.43    0.5882089     955.51    1624.44    2.3958826     303.75     126.78 0.77122366
                     1135.51 0.55947447       1158.28     2070.3    0.2934547      431.17    1469.29    1.4020281      523.98     373.73    0.6903084    1026.82    1487.48    1.3618108     575.76     422.79    1.2084799
                                 0.813961        250      307.14    0.7774528      356.19     458.15     1.401116      266.17     189.97    2.1117737      81.43      38.56    1.6575335     292.19     176.28     0.990566

                     6263.05    1.0080454     6204.61    6155.09    1.0761802    11872.57    11032.14   1.2454656     4048.61    3250.68    1.4891803    6249.36    4196.51    0.8374924      1032     1232.25    0.9876954
Molecular Medicine




                     7808.53 0.89130557       5177.63    5809.04 0.37605992       4144.94    11022.02   0.8551246     3444.04    4027.53    1.4862169    7911.92    5323.53 0.80598587       3918.8    4862.12    1.0289631
                     5704.34    1.1192734     8002.48    7149.71 0.90997535       15012.7    16497.92   0.7364262     2354.73    3197.51    1.0110122    4023.95    3980.12    0.6431748     579.88     901.59 0.68347335
                     6740.36 0.98812586       3861.24    3907.64    1.5332901     4972.92     3243.3    1.0377995     5203.35    5013.83    1.0642165    5520.57    5187.45 0.76177174      1707.58    2241.59    0.8533832
                     63874.96   1.8230344    117103.69   64235.59    35.90393    1468086.4   40889.29   2.7734284    179260.55     64635    7.0766444   456157.28   64459.54   2.9317875   188909.73     64435    2.2570455

                     2587.93    1.1490464     3164.83    2754.31    0.6728984     3868.52    5749.04    0.7409019     3179.64    4291.58 0.96275204      4863.13    5051.28    1.1056991    2546.79    2303.33 0.84449327
                      116.53    3.1638048       92.13      29.12    0.65469295       22.6      34.52    2.0946286      292.85     139.81    1.2474372     177.66     142.42 0.68315405       151.79     222.19    1.3605244
                     5188.87    0.9913133     8885.15    8963.01    0.5314974     7939.87    14938.68   0.9220902    12227.45    13260.58   1.2169244    5851.35    4808.31    0.823594     6424.61     7800.7     0.927538
                     15860.56   0.5264179     3949.84    7503.24 0.030124575         379     12581.09   0.5280946    16758.88    31734.62   0.7187156   25300.35    35202.17 0.19088067     2076.65    10879.31    0.935207
                     5675.65    1.0636392     7446.58    7001.04    0.6047519      3675.7    6078.03    0.8501871     4160.51    4893.64    1.486308     7216.59    4855.38     0.55887     2405.03    4303.38    0.8020755
                     4467.19    0.8167932     4771.51    5841.76 0.84135085       6969.49    8283.69    0.8162433     1526.13     1869.7    0.7700256    1660.36    2156.24 0.09767025        70.85      725.4    0.6495107
                     1761.17    0.9653504       858.1      888.9    0.5969805     1043.51    1747.98     1.150537     1167.68     1014.9    2.1960936    2080.14      947.2    1.766677     1013.79     573.84    1.0860391
                      912.92    1.1793044     1227.42     1040.8    1.2805464     6225.12     4861.3 0.72367567        614.35     848.93 0.75296324       750.87     997.22    0.5250049     133.85     254.95 0.96734124
                     23872.17   0.8485862   9103.03    10727.29   1.447867    25369.96    17522.3    1.3538643     6518.87    4815.01 0.38386822      10688.27    27843.59   1.6963469    5282.95    3114.31    1.6139969




                                                                                                                                                                                                                      UNCORRECTED PROOF
                      792.63    0.8820451    487.18     552.33    1.1395092    1348.78    1183.65     1.209768       581.1     480.34    0.5799472      399.63     689.08 0.94675106        61.34      64.79    0.9234638
                     3371.98    1.0196476   6889.29    6756.54    1.1281817    5583.45    4949.07    1.0412476     2297.44    2206.43    0.5766792      2165.2     3754.6    0.5902005    1348.85    2285.41 0.88435686
                      7914.6    1.1245542   7955.94    7074.75    1.8654697   15617.47    8371.87    1.0213413     7039.37    6892.28     0.951411     5941.01    6244.42    1.0070413     3232.2     3209.6    0.9674627
                     3696.29    0.8625242   1486.94    1723.94    1.1886532    5475.02    4606.07 0.95756555       2978.68    3110.68    1.4312273     3319.46    2319.31 0.64476377      1179.26    1828.98 0.88819134
                     5855.02    0.8099752   4129.14    5097.86    0.9519855    4723.79    4962.04    1.1568451     2866.72    2478.05    1.1258696     4134.79    3672.53    1.2616315     770.39     610.63    0.9273817
www.molmed.org




                                1.0347071      4.77       4.61                                                                           0.52376544      96.31     183.88
                     4718.59    0.7911134   1747.87    2209.38 0.90394163      3861.53    4271.88    0.7981557     2877.95    3605.75 0.53830487       3478.09    6461.19    0.8278419    1011.78    1222.19    0.8540643
                     2326.78    1.2059377   1657.26    1374.25    1.5471414    3365.28    2175.16    1.5545367     1435.91     923.69    1.3704507     1408.33    1027.64    1.6602116    2337.86    1408.17    1.3494927
                     11747.6 0.78117794     9108.87    11660.43   0.9460565   16919.02    17883.73 0.90378237      5295.46    5859.22    1.1381801    15511.62    13628.44   1.0167338    3179.55    3127.22    0.9301265
                      579.87    0.9948331    502.53     505.14 0.10356084        103.1     995.55    0.6892786     1286.38    1866.27 0.82926035       2199.53     2652.4    2.1767209     501.56     230.42    1.1700275
                     59964.08   1.113315    14786.75   13281.73   4.2381573   33017.02    7790.42    1.3305106     5571.78     4187.7    1.8164953    82166.37    45233.46   1.5444741    8867.15    5741.21    1.4712454
                     4085.13    1.0918132   3029.88    2775.09    0.2957557     505.97    1710.77    0.8261896     1060.72    1283.87    1.7263479     6554.08     3796.5 0.53579575       319.57     596.44    0.645987
                      313.78    2.1575148    472.28      218.9    0.441937      354.46     802.06 0.86108536        770.99     895.37    0.5329885      759.37    1424.74    2.1102362      361.8     171.45    1.089474
                     29905.77   0.6643601   8614.93    12967.26   11.528581   32501.49    2819.21    5.7660966    25237.11    4376.81    7.8927617    18695.19    2368.65    1.2144533    3408.74    2806.81 0.92796355

                     62106.3    1.0207745   43238.04   42358.07   3.9069355   193430.28   49509.47   2.5643325    51478.08    20074.65   2.6144829    74768.23    28597.71   3.1477423    72870.9    23150.21   1.293858
                     66032.68   1.3063526   78083.4    59772.07   1.068109    68698.94    64318.28   0.7520174    32520.96    43244.96   1.7912858    102083.55   56988.98   1.296488    56463.79    43551.34   1.2747492
                     14820.99   1.5982481   6705.61     4195.6    1.8355844   26268.04    14310.45   1.0809716      3974.7    3676.97    1.1010826    12328.48    11196.69   1.7427323    9459.69    5428.08    1.176276
                      102.87    1.9686239     87.84      44.62    1.1735983     145.89     124.31    1.9020649      157.51      82.81      1.31298      377.81     287.75 0.29038867        43.93     151.28    6.333891
                     6132.49    1.0412513   4872.65    4679.61    1.5303519    19848.8    12970.09   0.7134778      1772.4    2484.17 0.95203805       8317.48     8736.5    0.7189791    1653.58     2299.9 0.84578985
                     1225.04    0.9563353    765.03     799.96    0.8579178    1148.16    1338.31    0.9937109      807.41     812.52     1.488098     1726.03    1159.89    1.0593697     903.78     853.13    1.0058932

                      299.97    0.7837702     155.5      198.4    1.4626158     444.84     304.14     1.511765      422.75     279.64    6.8380933      347.17      50.77                                       2.4946048

                      281.09    0.9057317     55.15      60.89    0.9800186     327.14     333.81    1.3900113      158.92     114.33    1.7100089      857.33     501.36    1.5082691      197.9     131.21 0.01121902

                     44427.03    1.13044    43426.19   38415.3    2.235968     71074.6    31786.95   2.5566266    101790.55   39814.4    3.1018136    66049.99    21293.99   2.341026    115559.91   49362.93   1.5656195

                      1049.2    0.8077028    683.26     845.93 0.33301768      2827.76    8491.32    1.2878337        671      521.03    1.5710658     2406.26    1531.61    3.3682148     343.76     102.06    0.5974346
Molecular Medicine




                     1889.26    1.325585    3064.05    2311.47    1.2863235    7525.07    5850.06    0.6888419      660.93     959.48    0.7851158      2099.8    2674.51    2.1525865    1009.52     468.98    1.0995624
                       15.87                                                                         0.58938634     166.26     282.09 0.87419534       1742.28    1993.01    0.9539756      57.83      60.62
                     2411.27    1.0871316   1255.55    1154.92 0.43548605       668.85    1535.87    0.7535454      686.51     911.04    0.6209062      1910.1    3076.31    0.5321151     508.42     955.47 0.67284757

                     1980.37 0.86998564     1542.85    1773.42 0.92874396      2137.56    2301.56    1.3831692     1015.26     734.01    1.0239133      850.36      830.5    0.9630936     122.91     127.62    0.9787304
                     1576.07    0.6454118    870.17    1348.24    2.754016     4243.14    1540.71 0.80211586         536.8     669.23    1.4287894      730.64     511.37    1.1430876      21.25      18.59    1.4155948
                     4550.15    1.1493417   3270.13    2845.22    0.8228396   13075.95    15891.25 0.79490453       1855.8    2334.62 0.88805586       2019.75    2274.35 0.82928216      1035.79    1249.02    0.9548385
                                0.7209394    182.34     252.92    0.7246262      274.8     379.23     0.997822      274.88     275.48 0.59134656        215.67     364.71    0.9759562      288.6     295.71    0.9875171


                      431.79    1.1962777   2451.52    2049.29    2.2706215   12407.38    5464.31    1.0118998     1006.81     994.97    1.4626386      708.78     484.59    1.3568457     551.49     406.45 0.86050344
                     63874.96   1.1049709   48484.49   43878.52   1.5503513   99715.93    64318.28    1.100579    60996.76    55422.43   1.3562568    87423.69    64459.54   1.1078727   71385.78      64435    0.7981353
                     1687.97    0.8158992   1955.49    2396.73    0.6570013    7959.61    12115.06   1.1311504     3791.65    3352.03    1.2714642     2939.32    2311.76    1.0865395    4197.65    3863.32    1.1390815
                                                                   1.3557435    1046.39     771.82    0.6931412     155.43     224.24    1.6171981      190.7     117.92




                                                                                                                                                                                                                      UNCORRECTED PROOF
                     34195.58   1.0422609    25189.32   24167.96   1.4019841   28698.84    20470.16 0.45893738     6760.01    14729.7    0.5464621   14698.71    26897.95    0.780821     9555.5    12237.76   0.7951106
                     11423.67 0.85990804     5028.08    5847.23    0.9812748   10892.65    11100.51   1.028986     1322.71    1285.45    1.0941623    6736.55    6156.81 0.74541026      1129.14    1514.79    0.8323364
                      182.18    1.6640377     329.13     197.79    0.9175065    2589.35    2822.16    1.1826782     933.76     789.53    0.9039925     278.05     307.58    1.6106738    1362.63       846     1.2429775
                     6477.04    0.9158295    7097.01    7749.27    1.1901869   21125.16    17749.45   0.8463134    9414.01    11123.55   0.9768906    3259.21    3336.31    0.8429993     4975.5    5902.14 0.87651014
www.molmed.org



                       2750     0.84254277   1789.94    2124.45    1.0599954    2178.99    2055.66    0.7210711    1026.25    1423.23 0.52786857      3016.32    5714.15    1.0851847     1058.5     975.41    3.0658267
                     7867.28     1.014272    4254.12    4194.26    1.6817087   20572.78    12233.26   1.1574476    5678.97    4906.46    0.8585347    5860.77    6826.48     1.154646    2685.88    2326.15 0.76237476

                     85910.01   0.7929961    31395.32   39590.76   2.226525     65830.8    29566.61 0.42720005     6093.97    14264.91   1.4839096   46684.08    31460.19    0.630507    7396.32    11730.75   0.5904146
                      450.92    1.2425257    1659.48    1335.57    0.7517017   24033.01    31971.47   0.7614172     904.32    1187.68    1.158432      924.73     798.26    0.7904638     274.37      347.1    0.9024424
                     63874.96   1.3719817    39428.6    28738.43   2.4278893   125021.13   51493.75 0.77442855     17995.9    23237.65   1.848117      90854     49160.31 0.77669257     17609.61   22672.56   1.1041526
                                0.84739494    112.39     132.63 0.32302594       176.44     546.21 0.91917413       453.64     493.53    4.4789233      49.94      11.15    0.89666885    269.18      300.2    0.74827313
                     2379.03    0.9841619     3079.6    3129.16    0.7068245     8678.2    12277.73   0.7990241     1732.5    2168.27 0.84645456      1444.17    1706.14    0.8541306     1246.8    1459.73 0.83522767

                     15520.42   0.6440289     9513.1    14771.23   1.7834935   24667.89    13831.22 0.68759143    24578.32    35745.53   0.6863641   15036.37    21907.28    1.165761    13473.97   11558.09    1.128689
                     2026.46 0.66254705       290.56     438.55    0.7693175     265.83     345.54    1.0515321    1111.48    1057.01    0.5085132      534.6     1051.3    0.5916044     479.17     809.95    1.0024301
                                                                   0.4749009     400.18     842.66    1.8711326     281.83     150.62 0.87458646        29.08      33.25                                       4.1649823
                     63874.96   1.3576611    23955.97   17645.03   7.991652    68318.16    8548.69    5.527546    24556.79    4442.62    3.5272744   83149.07    23573.18 0.64879245       9117     14052.26    1.210708
                     11621.53 0.59904826     11604.9    19372.23 0.11959507     2767.88    23143.76   0.6752441   17379.48    25738.07   0.6599164   14931.77    22626.76   1.0655764    11699.07   10979.1 0.96654475
                     3379.05 0.51955694      2680.82    5159.82 0.27135193      2535.99    9345.76 0.99060816      2017.74    2036.87    0.5699958     3005.4    5272.67 0.68109107      1155.58    1696.66 0.97782415
                     63874.96   1.0285581    41778.89   40618.89   0.9924351   58324.58    58769.16   1.8778281   121373.42     64635    1.1088802   71477.91    64459.54   1.3671544    88092.59     64435    1.3914471
                     18849.87   1.1428318    16495.36   14433.76   1.5500199   13538.37    8734.32    0.7183688    6354.64    8845.93    2.060146    11476.25     5570.6     1.036429    5424.97    5234.29    0.8509604
                     63874.96   1.3044045    48658.03   37302.87   2.310885    133834.81   57914.96   1.3055665   82668.68    63320.16   2.2079575   142323.92   64459.54   0.8290224    63324.55   76384.61   0.9838976
                     30054.28   1.0190363    14242.58   13976.52   1.2975463   25955.26    20003.34   0.8940737    7236.32    8093.65    2.059014    21368.57    10378.06   1.2601433    9387.79    7449.78    0.9470168
                     20061.04 0.92135674     15390.5    16704.17   1.2357392   32993.53    26699.43   1.0300105    16927.1    16433.91 0.76783097    14803.39    19279.49   0.9534523      5984     6276.14    0.9746192
                     11652.58 0.50677115     2873.58    5670.37    1.1941079    2482.61    2079.05    1.1246144     1020.7      907.6    1.7563422   11243.26    6401.52 0.55764085       920.52    1650.74    1.3430121

                     10237.29     1.11611    3510.11    3144.95 0.95533574       859.42      899.6    1.4329159   10398.37    7256.79    1.3511733   16720.31    12374.66    1.153271     2089.9    1812.15    0.8788296
Molecular Medicine




                     7282.89    0.6820862     747.28    1095.58    1.1405039    1238.61    1086.02 0.74593586       417.56     559.78    1.4101298    7773.58    5512.67 0.73398954      1399.05    1906.09    0.7533959
                     5374.64 0.75601864      2501.59     3308.9    0.5749355    4146.05    7211.33    1.0678241     5441.6    5095.97 0.98419535      6706.74    6814.44    0.8221388    1762.83     2144.2 0.91014874
                      911.96    1.5947838     840.18     526.83    1.2345524    1565.61    1268.16    1.3958461     842.77     603.77    1.4058244    1277.81     908.94    1.2028371     840.29     698.59     1.236367
                     2147.25     1.327977    1428.85    1075.96    1.4566789     5011.5    3440.36 0.92715555      1170.33    1262.28    1.395929     2408.48    1725.36    1.2019923    1444.35    1201.63    1.2207317
                     2235.65    0.9144562     807.73     883.29    1.8857108    2050.39    1087.33    1.8005459    1016.03     564.29    1.4551693    2006.14    1378.63     1.716984     688.15     400.79    1.3139334
                      969.58    1.3372844     858.55     642.01    2.6433156    3298.25    1247.77    0.5338979     735.77    1378.11    0.5510745     887.77    1610.98 0.83307505      1026.64    1232.35    0.7296896
                      9113.7    1.0163561    4364.04    4293.81    0.520492     4164.93    8001.91    1.0312138    4614.64    4474.96    0.8548142    7063.68    8263.41    0.5639698    3275.26    5807.51     0.625003
                     35798.6    1.0035641    23320.22   23237.4    1.119154    47798.35    42709.36   1.4761754   35939.63    24346.45   1.1251767   29595.76    26303.21   1.2313402    11093.76    9009.5    1.2759453
                     10698.65   1.9893303    9376.23    4713.26 0.51541567     11901.05    23090.2    0.9427252   10630.81    11276.68   0.768579    15597.25    20293.62 0.42272416     2429.59    5747.46 0.69160664
                                1.0469137     279.17     266.66    0.5492159     299.07     544.54    0.9871025     259.45     262.84    0.770071      316.53     411.04    0.5811611     311.45     535.91    1.2459233
                     63874.96   0.8384245    36168.76   43138.96   0.5906746   22082.05    37384.46   0.7681739   27872.72    36284.39 0.84098876    41402.18    49230.36   1.0415198    28090.59   26970.77   0.8383041
                                1.8123364     297.64     164.23    1.4807804     842.49     568.95    1.5687078     374.78     238.91                                       1.4812826     198.64      134.1     1.053494
                     9677.26    0.9762232    8623.78    8833.82      0.89846    14251.39   15862.02   1.3458571    7576.92    5629.81    1.1736355    10772.26   9178.54    1.1809428   5731.21    4853.08    1.2260238




                                                                                                                                                                                                                     UNCORRECTED PROOF
                     2563.35    1.7660238    2106.16     1192.6     2.273174    8443.41    3714.37    1.3693509     2798.2    2043.45    1.2315677    3006.22    2440.97    1.3288821   1916.66    1442.31    1.2039839
                      854.68 0.56932396       374.86     658.43 0.12484626       108.61     869.95     0.815512     440.14     539.71    1.1225365    1228.56    1094.45
                     9198.96    1.2970914    5054.35    3896.68     1.881182     5211.1    2770.12 0.84621125      4229.77    4998.48    1.1126764    5051.54    4539.99    0.7825275   5291.67    6762.28    0.9933595

                                1.2424159     756.83     609.16    0.5948602    2230.22    3749.15                                       0.58285224    388.71     666.91    1.2238914    388.61     317.52    0.9185216
                     1103.03 0.86550146      1014.16    1171.76    1.1390882    1000.37     878.22    1.4397172     364.45     253.14 0.63132006       336.26     532.63                                      4.1793747
www.molmed.org




                     11038.47   0.7819206    10719.74   13709.5 0.55075604      14660.96   26619.7     1.159504    12038.47   10382.43   1.2540398    26023.97   20752.11   1.1000241   6589.53    5990.35 0.99507076
                                 0.886387     629.45     710.13 0.78736866       352.19      447.3    0.75667995    119.79     158.31 0.55601555       178.62     321.25    1.258032     223.98     178.04    1.9289426
                      130.59 0.97205365       174.61     179.63    1.1507204       766      665.67      0.95772     315.54     329.47    1.0504557     243.17     231.49    0.9569648    345.56      361.1    0.65822434
                     2405.06    0.5711136    1072.34    1877.63 0.20503172        813.9    3969.63    0.7517812      729.1     969.83    0.8421148    1675.48    1989.61 0.046866193      14.14     301.71 0.94017625
                      155.29 0.78115124        222.3     284.58    0.7640707     518.72     678.89 0.88686264       142.98     161.22    1.9963129     433.14     216.97                                      0.78808975
                      386.54    1.2203875     263.86     216.21 0.37966663       209.09     550.72 0.14388168         3.21      22.31    0.7442131     243.06      326.6    4.561246     177.25      38.86
                      476.77    2.3994284     159.49      66.47    1.7823316     422.27     236.92    1.1836852     248.42     209.87    1.1342343     632.88     557.98    1.5828137    208.14      131.5    1.8648566
                                                                                                                                         0.8606558     143.85     167.14
                                0.87640387    538.41     614.34    0.5360043    1210.48    2258.34    1.3140042      325.4     247.64    0.9686515      202.7     209.26 0.04063755       12.85     316.21 0.78736794
                      532.58    0.7557128      74.74       98.9    0.57039857    564.86     990.29 0.88250077       207.22     234.81    1.0334628     710.95     687.93 0.67659193      203.37     300.58    0.8553881
                     2545.74    1.2099575    1654.98     1367.8    1.2604681     6624.1    5255.27    0.5943957    1496.51     2517.7    0.7575982    2045.25    2699.65    0.6830759   1308.35    1915.38 0.82514656
                     1645.14 0.75424635      1819.71    2412.62    0.6752478    3684.78    5456.93    1.3731217    1676.87    1221.21    1.3447076    1352.87    1006.07    1.6227812     495.5     305.34     0.785706
                      303.09                                       0.93091875    371.66     399.24    0.6646669     137.38     206.69    1.1236367     134.96     120.11    3.8858218    175.95      45.28    2.3108642
                      419.63    1.4002291     831.12     593.56    0.6267115    4806.52    7669.43    0.9518045     1580.5    1660.53    1.3125252    2600.48    1981.28    0.8828272    830.97     941.26 0.72043866
                                0.02152642      1.76      81.76    4.4461164      91.59       20.6
                      422.63 0.78274393       455.33     581.71     1.124098     2282.2    2030.25    1.0345043      663.5     641.37    0.5922352     307.53     519.27        0.01       1.78     280.74    1.0068015
                      460.15    1.0032896     609.99     607.99    1.3896431     715.43     514.83 0.66768575      3048.82    4566.25    0.6261399    2419.68    3864.44 0.53009486      359.68     678.52 0.68461037
                      652.69    0.9962513     345.49     346.79    1.2415284     711.88     573.39    1.2628621     175.26     138.78 0.90908736       701.47     771.62    0.6328915    180.95     285.91    3.3815663
                     17109.45   1.0227194    6575.85    6429.77    1.7217041    19215.27   11160.61   1.4714981    11199.44   7610.91     1.238749    13645.91   11015.88   1.1287447   10994.99    9740.9    1.1131473
                     1169.62    2.0705743     328.89     158.84    1.2750598    2160.13    1694.14     9.653492     261.32      27.07    0.9021011     276.07     306.03    1.831783     303.27     165.56    1.6598876

                      538.13     1.016081     377.85     371.87     1.305982     854.06     653.96    0.9114701     108.31     118.83    0.8352521      275.7     330.08                                      0.25188717
Molecular Medicine




                     24163.41   1.3973615    37334.97   26718.19    2.314938    90205.29   38966.61   1.2381264    18507.91   14948.32   1.0919063    26067.33   23873.23   1.2743235   19592.66   15374.95   0.8903784

                     1148.64 0.68101645       858.36    1260.41    0.7395647      2222     3004.47    1.0741509     543.95      506.4     1.149099     516.52      449.5                                      0.87729716
                     10716.68   1.0541874    9165.58    8694.45 0.68869036      12735.51   18492.36   0.7702258    7967.17    10343.94 0.67577106      6740.6    9974.68    0.6603979   3582.89    5425.35 0.79843014
                       78.87    1.2615776     227.74     180.52     1.153514    1386.87     1202.3    1.2354281     319.84     258.89    1.3606668     441.55     324.51    1.3567138    140.04     103.22    1.0261339
                     1531.17    0.8618397    1577.52    1830.41 0.38849482      1568.54    4037.48     0.927666     2262.8    2439.24     0.996609    2562.78     2571.5    1.0638925   2489.87    2340.34    0.8840538

                     9596.97    0.5043434    3436.49    6813.79 0.16541678      1672.19    10108.95   0.5837559    1374.36    2354.34    1.4295119    10019.12   7008.77 0.30967787      407.66     1316.4 0.75526196

                     14166.29   0.5509075    3907.89    7093.55    1.6892009    16833.68   9965.47    1.2187042    9448.59    7752.98    1.4681834    17910.31   12198.96 0.78595155    4787.49    6091.33 0.85772276

                     68879.63   1.0018765    38480.2    38408.13   0.9194026    42662.32   46402.22   0.6633228    42873.87     64635    0.54412943   19138.73   35173.12   0.730583    16564.26   22672.66   0.7404807

                     1041.49    1.2249154      86.92      70.96    1.0324674     453.47     439.21                                       0.73416525    766.63    1044.22    31.226624    307.27       9.84    1.1912522
                     8547.54    0.7069915     8807.7      12458    0.5187245     5906.41    11386.41   0.9858133    7865.42    7978.61    0.9621333     6286.04    6533.44 0.98409283       3219.44    3271.48    0.9194643




                                                                                                                                                                                                                         UNCORRECTED PROOF
                     63874.96   0.9748648    63196.38   64825.79 0.66506416     55447.03    83370.95   1.6492839    62831.71   38096.36   1.5101721      97345     64459.54    1.808355    115160.66   63682.55   1.4563658

                     12892.25   0.7867844    10257.34   13037.04 0.33399332      7563.36    22645.24   0.8198034    3717.12    4534.16    0.8515875    18492.52    21715.35   0.9679091     6419.27     6632.1 0.69296426
                                0.53346056    170.51     319.63 0.34447142        297.83      864.6    2.5017445      215.1      85.98    0.7325547      122.93     167.81                                        1.8199335
www.molmed.org




                     2281.53    0.5399918     564.07    1044.59 0.41881955         237.5     567.07    1.2396911    1320.68    1065.33 0.77414495       1165.87    1506.01    0.7169998      469.47     654.77    0.8213485

                     41895.57   1.3132596    18761.11   14285.91   0.9471193    34213.38    36123.62   1.6574475    14793.58   8925.52    4.5300746    94171.96    20788.17   0.9349798    17620.05    18845.38   1.0526446

                     4699.81    0.6919862     1563.1    2258.86    1.0016656     3421.96    3416.27    1.8276346     948.25     518.84     4.027605     1192.01     295.96 0.13610199         38.54     283.17     1.398061
                     1291.73 0.78267986      1544.11    1972.85    0.7861573     2047.13    2603.97    1.1349183     806.28     710.43    0.8743565       796.6     911.07    0.6241329      278.02     445.45    1.0358813
                     6888.86 0.55579185      4173.68    7509.43 0.36964667       2416.82    6538.19 0.93026024       2973.8    3196.74    1.5911592     5190.95    3262.37    0.9913906     2066.97    2084.92    0.8147167
                      828.36     0.831178     721.13      867.6    0.70883226    2617.03    3692.03    0.8149685    1086.41    1333.07    1.1185967     2003.72    1791.28 0.71875405        493.13     686.09     0.918869

                     1049.12    0.7595241    1759.43    2316.49 0.76014495       1190.06    1565.57    1.2744157    1030.62      808.7    0.88126737     784.61     890.32     1.383597     1138.05     822.53 0.93696153

                                                                                                                                          0.61797553      34.31      55.52

                     44118.92   1.5597843    24587.16   15763.18   4.2104373    172372.83   40939.41   0.9346578    33900.75   36270.76   0.8909763      46649     52357.17 0.87677777     52045.36    59359.81   1.2593993

                     6942.66      1.18996    4021.22    3379.29     2.548712     9426.08    3698.37    1.4093869    1378.93     978.39    1.3009986     7656.74    5885.28      0.92633     2166.13     2338.4    0.9806639
                     1709.44 0.48406488       149.76     309.38 0.46382543         773.8     1668.3 0.48712543       184.83     379.43    0.7763232      699.18     900.63 0.59566724        279.91     469.91 0.34142596
                     1509.18    1.2545487    1168.06     931.06    0.8478805      881.27    1039.38    1.1379495     276.92     243.35 0.40956625       1092.69    2667.92    0.8228198      725.76     882.04    0.9989646
                     11520.89   1.5466472    13559.24   8766.86    2.2941327    85900.54    37443.58   1.3733896    13187.41   9602.09    1.2910776    12468.88    9657.73    1.5139321     6413.47     4236.3    1.4033178
                     17084.09   1.0307801    12443.69   12072.11   2.4380648    109056.72   44730.85   1.2084664    17025.83   14088.79   1.1490213     9997.68    8701.04    1.3292174     8480.42    6380.01    1.0144211
                      669.04    1.1297972      850.5     752.79    1.3676926     1279.75      935.7    1.3322856     495.89     372.21    3.8925843      218.88      56.23    0.39123738      45.72     116.86    1.2009166
                     7105.61     1.180022    7365.65    6241.96    0.6409425     5082.36    7929.51 0.80826104      3871.74    4790.21    0.6487571     3118.53    4806.93    0.5424496       2608     4807.82    0.5323511
                     21526.16   1.1020359    11349.02   10298.23   1.5952089    10944.92    6861.12    1.2353852    4805.92    3890.22    1.0162604    16893.56    16623.26   1.3649664     2878.25    2108.66    1.2005762
                     2434.45    1.1210611    1939.29    1729.87     1.546648     5168.48    3341.73    0.9726836    2208.41    2270.43    0.9269709     3673.66    3963.08 0.89094555       1821.85    2044.85    1.0068547
                     63874.96    1.419279    44791.68   31559.46   0.8949424    11521.05    12873.51   1.3753653    27957.31   20327.19    1.331375    85819.82    64459.54   1.6309694     8166.72    5007.28     1.517934
Molecular Medicine




                                0.6710299     442.92     660.06                                        0.92385995    469.21     507.88 0.52803206        139.58     264.34 0.73575133         227.2      308.8    0.9512047
                     14557.34   0.8592048     4376.6    5093.78    0.8380093     1517.66    1811.03    0.7225747    2226.39    3081.19    1.0328212    12371.35    11978.21    0.784224      982.17    1252.41    0.8314258

                      671.54    1.3285648     831.19     625.63 0.91811776       1827.44    1990.42 0.35908285       855.91     2383.6 0.84833103       2601.28    3066.35     0.774104      858.28    1108.74 0.78859866

                     32478.93   1.1467037    11704.61   10207.18 0.91453946      14561.7    15922.44 0.73640895     5834.87    7923.41 0.95032465      17636.43    18558.32   0.9920179     5242.14    5284.32    1.1936675

                     63874.96   1.7262743    48529.68   28112.38   1.6615465      20217     12167.58    1.462816    94549.11     64635    1.7949466    115701.43   64459.54   1.2819057    24719.27    19283.22   0.7693413
                     6333.66    0.9853875     864.51     877.33     0.532142      689.64    1295.97 0.91693234      5675.49    6189.65    0.6780104      8734.3    12882.25   1.3084909      635.22     485.46    1.1176449
                      808.37    0.9123034    1239.72    1358.89    0.6779869     1353.75    1996.72    1.4384714     633.92     440.69 0.71782434        984.13    1370.99    1.2256062      620.12     505.97    1.0812434
                       47.31                                       0.78917694     163.77     207.52 0.26579788        241.9     910.09 0.75710464        747.55     987.38 0.21207693         76.95     362.84 0.91000456
                                0.72362876    245.52     339.29    0.7820374      906.96    1159.74     0.301379      90.48     300.22      0.92797      190.67     205.47 0.099740006         8.44      84.62    0.93444103
                     1792.59    0.9120434     1934.9     2121.5 0.78992885       2883.13    3649.86 0.73412794       362.16     493.32 0.59356266        858.44    1446.25         0.01        5.96     685.19    1.1757507
                     3673.03      1.12713    4006.53    3554.63     1.266959    14072.48    11107.29   1.2720844    4248.38     3339.7 0.70766014       9057.08    12798.63    1.406885      8138.9    5785.05    1.1214905
                     4380.66     1.134496    4920.91    4337.53    2.0040045    15904.34    7936.28     0.855802    4219.54    4930.51    0.6910213     5971.91    8642.15    1.1414407     2328.95    2040.36    1.0695837
                     5332.22 0.98210216      3411.44    3473.61 0.68559325      6429.37    9377.82 0.49431318       1381.2    2794.18 0.57231677       1677.1    2930.37    0.4703474     631.94    1343.56    0.6720699




                                                                                                                                                                                                                     UNCORRECTED PROOF
                     7583.74    1.3658227    8806.36    6447.66    1.048052    18477.66    17630.48 0.97278535     9191.44    9448.58 0.67596805     10146.97    15011.02   0.897103      5603.7    6246.44    1.034041
                      552.95 0.86610293       321.61     371.33 0.015236746       13.57     890.61    0.9172453    1568.04    1709.51 0.65546894       595.31     908.22    1.0671084     611.88      573.4    1.7083426
                     7219.05    1.3719487    10155.74   7402.42    0.9069733    4481.21    4940.84    1.268919     3458.87    2725.84    0.7199039    1489.15    2068.54    1.3931999     1133.8     813.81    1.0087066
                     1784.57    1.8919357     898.31     474.81    0.7825586    4034.16    5155.09    0.8175252    1058.27    1294.48    1.3422594    1501.76    1118.83    1.0088364     466.95     462.86 0.98381335
                                                                   2.019023      823.62     407.93    1.9117931     178.16      93.19    1.0631782      121.5     114.28    0.7895974      285.4     361.45    0.7484904
www.molmed.org



                     63874.96   2.1497235    41633.35   19366.84   7.135953    157172.23   22025.4    2.6753376   59839.84    22367.21   2.0394058   100252.39   49157.65   1.7155275   74433.67    43388.21   1.3094095
                     2340.29    1.4072541    2119.93    1506.43    3.4927135     6840.2    1958.42    1.3244305    2829.01    2136.02    0.7526449     925.55    1229.73 0.84896606       803.02     945.88    0.7227667
                     4590.64    1.8602993    15134.13   8135.32    3.0488768   41156.85    13499.02   0.661526      3704.4    5599.78    0.7872871    3341.27    4244.03    1.049784     5972.83    5689.58    1.104998
                     9127.37    2.8607035    28698.49   10031.97   7.3621507    46811.2    6358.36    1.8809725    2898.24    1540.82    2.7850997    6039.85    2168.63    6.2966228   11578.04    1838.77    2.5127451

                      286.01 0.56272286       175.17     311.29    2.5182507    1505.36     597.78    1.1814717     421.62     356.86    1.4517528     271.26     186.85    0.2607575      43.51     166.86    0.6322817

                                1.7488863     899.05     514.07 0.64881396      1127.47    1737.74    1.388292      921.09     663.47                                       1.1258919     705.36     626.49    1.2045753

                      274.31    1.0426604     264.94      254.1    1.2180034     678.16     556.78    1.4359561     144.17      100.4    0.5779844      292.2     505.55    1.8642439     139.52      74.84    1.276399

                     3687.72      1.46696     5002.7    3410.25    3.227793     12806.3    3967.51    1.2975532    6006.49    4629.09    1.0225737    6645.85    6499.14    1.6949636    3525.66    2080.08    1.3818706
                     37704.2     1.224715    14296.11   11673.01   2.5927386   138357.77   53363.56   1.1483414    29170.1    25401.94   1.4277849   13927.77    9754.81    1.2376958   16048.83    12966.7    1.1315705
                     63385.96   0.9854166    40751.42   41354.51   1.5801824   62019.02    39248.01   1.0200071   25322.27    24825.58   0.9231419   52327.42    56684.05   1.183965    30970.44    26158.24   1.1719685
                     63874.96   1.5475814    90039.62   58180.86   1.0528922   39108.38    37143.76   1.8345228   55416.22    30207.43   1.4662757    51576.7    35175.31   1.0228568   34892.82    34113.1    1.2275301
                     36599.07   1.1503292    29946.37   26032.87   4.450683    199146.3    44745.11   1.018719    61086.32    59963.86   0.9718806   41341.84    42537.98   1.0812166   37593.22    34769.37   1.0708679

                     2689.93    1.5177369    3824.53    2519.89    2.5361047   15310.54    6037.03    1.5992229    2662.85    1665.09    1.9267787    2926.43    1518.82    1.7684968    1065.59     602.54    1.2765697
                      180.85    1.9659477     144.91      73.71    1.6598388     269.84     162.57    1.0634093      77.48      72.86                                                                          6.554123
                     38109.4 0.49953884      11985.23   23992.59 0.22011083     5464.37    24825.54   0.773618    20518.05    26522.2    0.888134    17861.29    20111.03   0.6343824    5498.51     8667.5 0.75977045

                     4391.16    2.2134902    2278.08    1029.18    3.3286557    4528.17    1360.36    5.0961146    2619.25     513.97    2.7942266    6943.01    2484.77     2.70239     2004.93     741.91    1.6713463
                     63874.96   1.2616909    81045.45   64235.59   7.101489    456755.56   64318.28   3.223079    208323.7      64635    1.934851    124719.61   64459.54   2.5418673   163785.22     64435     1.54544
                     63874.96   0.6957099    60742.26   87309.76   2.9337494   184245.2    62801.95   2.0354443   112354.41   55198.96   0.950533    61387.15    64581.82   1.2244676   49995.76    40830.61   1.1123245
                     63874.96   0.8535013    32757.66   38380.33   1.6999762   65524.29    38544.24   1.2571483   37419.47    29765.36                                      0.9264217   10756.84    11611.17   0.9803031
                     63874.96   1.1622517    74657.92   64235.59   2.775388    178508.19   64318.28   2.3216689   150061.06     64635    1.9299664   124404.75   64459.54   1.4307435   92189.95      64435    1.9055059
Molecular Medicine




                                0.40181214     63.86     158.93                                       0.7286089     386.17     530.01    1.3912212     567.66     408.03 0.22290847        82.65     370.78    0.915553
                     20149.6    1.5558438    41238.31   26505.43   2.1766148   84065.67    38622.21   1.0192682   33266.02    32637.16   2.7054756   29254.04    10812.9    1.4370985   16361.97    11385.42   1.9766808
                     3545.51 0.81107193      1969.38    2428.12 0.20340803       570.71    2805.74    1.2377025    1144.85     924.98    1.2185161    4643.57    3810.84    1.191194     2416.23    2028.41 0.91098136
                      326.58    1.1309756     329.08     290.97    0.4442766     147.06     331.01    1.7051227     269.29     157.93 0.76802325       285.72     372.02    9.320248       45.11       4.84    2.0512352
                     1196.68    1.7481048    1176.09     672.78    2.2956014    1838.57     800.91    2.7946856    1058.04     378.59    0.768132      284.47     370.34 0.97596323       250.52     256.69    1.359769
                     6503.03    0.9681524    3899.35    4027.62 0.75016046      3927.48    5235.52 0.88472724      3502.98    3959.39    1.1856045    7206.72    6078.52 0.44390956      1675.43    3774.26    0.6561041
                       551.7    1.0486866     975.74     930.44    0.8721091    9098.54    10432.8    1.0417801     879.95     844.66    1.3231078     446.84     337.72    2.107892       189.9      90.09    0.9328919
                      668.51                                       3.6768453    2962.14     805.62    1.2916802     277.75     215.03    1.0765665     575.78     534.83    1.0803926     157.37     145.66    0.3846925
                     2299.06    0.9342229    1417.73    1517.55    1.9257072    7812.96    4057.19    1.0171484    1960.34    1927.29    0.6878391    1284.23    1867.05    1.0068085      974.5     967.91    1.0171528
                      797.88    1.2332488    2680.01    2173.13    0.4807812   12065.93    25096.51 0.71731925     2806.87      3913     0.6997429    1282.09    1832.23 0.69286805      2610.99    3768.38    0.7957178
                     8326.42    1.7044114    8552.26    5017.72    3.7978802   54993.19    14479.97   0.9694116   15660.04    16154.17   1.2672529   10409.14    8213.94    1.1090692   15180.33    13687.45   1.5572332
                     5026.55    1.1413295   8506.82    7453.43 0.88028526     10080.78    11451.72   0.7912647   7949.56    10046.65 0.58704346     4284.56    7298.54    1.1560545   8875.99    7677.83 0.86267716




                                                                                                                                                                                                                  UNCORRECTED PROOF
                     5053.53    1.6653631   7737.86    4646.35    2.6952896   26562.43    9855.13 0.89324015     6894.09    7718.07    1.3443434     7168.9    5332.64    0.9684545   3917.66    4045.27    1.2548743
                     1293.97    2.5081398    174.09      69.41    0.2347464     112.69     480.05    1.2057431   1137.51     943.41 0.90487844      1209.37     1336.5    0.926401     1144.8    1235.75    1.0421093

                     46062.75 0.86641943    15328.06   17691.27   1.0115039    30431.4    30085.3    1.266071    14021.85   11075.09 0.78551835    22146.81    28193.88   0.7866256   7975.44    10138.8 0.94816685
www.molmed.org



                     21938.39   1.1716529   6585.65    5620.82    3.288145    35484.61    10791.68   1.2575513   4769.15    3792.41    1.1756308    8875.73    7549.76    1.1387007      4972    4366.38    1.1995701

                     3432.34 0.53161037       592.4    1114.35    0.8998771     1500.5    1667.45    1.3877406      705      508.02    0.7990547    2111.51    2642.51    1.5449893    401.45     259.84    1.1941905
                     14630.03   1.5594091   17379.24   11144.76    5.93811    66222.76    11152.16   1.4912554   11523.87   7727.63     2.80725    17496.55    6232.63    1.1297939   4593.29     4065.6    1.1252185

                      211.35    1.262467     489.61     387.82    0.8525851     840.18     985.45 0.82010454      106.63     130.02    1.2915258     400.98     310.47                                      1.6717118
                      857.22 0.97482556      587.04      602.2    3.5972772     908.96     252.68    1.8327965    478.03     260.82    1.0818837     740.69     684.63 0.62579596      165.11     263.84 0.88840246
                     1004.01    1.415916    1812.33    1279.97    1.4854805    3772.66    2539.69    1.0213774   1492.59    1461.35    1.1007165    1654.52    1503.13    1.2907233   1590.21    1232.03 0.99067086

                      1926.6    0.6636934     854.2    1287.04 0.63237524      1241.34    1962.98    0.9215448    645.45      700.4    1.0138676    1024.28    1010.27                                      0.8397232

                     4283.43    1.1100354   3094.69    2787.92    1.5490316    3489.55    2252.73    1.079266    1396.84    1294.25    1.063235     4449.83    4185.18 0.73179287      961.81    1314.32    1.2056878

                      556.62    1.1442485    616.83     539.07    1.2802199    1038.86     811.47    1.2452077    199.42     160.15    1.003595      103.29     102.92                                      0.711545

                                0.9957992   1095.17    1099.79    2.6795614   18230.02    6803.36    0.9530396   1369.07    1436.53    1.407115      267.38     190.02    0.9252888    424.43      458.7    1.095287

                     40762.99   1.2640061   17920.6    14177.62   5.6922917   27691.01    4864.65    2.5710573   36562.34   14220.74   4.5832267   67288.32    14681.43   3.1488006   17219.09   5468.46    2.107117

                     7522.02 0.83587384     1862.26    2227.92    1.0026668    1748.28    1743.63    1.0424619    927.52     889.74    1.208415     2815.74    2330.11 0.93389887      625.32     669.58    1.5298258
                     63874.96 0.91711307    50824.27   55417.67   1.2481242   38766.83    31060.07   2.074792    95674.02   46112.59   1.4936801   89246.69    59749.53   1.7377037   74003.43   42586.91   1.2601949
                     37666.72   0.9633171   33543.8    34821.14   2.1757205   139938.6    64318.28   0.6125093   39589.54     64635    0.7369007   63738.75    86495.71   1.3224736   42005.52   31762.84 0.69840115
                     30957.54   1.1575507   17855.82   15425.52   0.8721346   25395.47    29118.75   0.8360282   10504.77   12565.09   0.6321602   25670.08    40606.92   1.1828325   16233.04   13723.87   0.6720453
                     7448.49 0.87468386     9232.42    10555.15   0.9983702   32667.48    32720.81   1.1735388   26637.31   22698.28    1.45528    23671.38    16265.86   1.2549868   11153.28   8887.17 0.87668324

                     1414.55 0.85039765      993.46    1168.23    0.7202971    1416.99    1967.23    0.980649      726.2     740.53 0.65069246       456.22     701.13 0.62817335      387.74     617.25    0.8119906

                     6206.54    0.9909784   5081.46    5127.72    2.7539287   12112.22    4398.16    1.3662533   7358.49    5385.89    0.9606753    6332.57    6591.79    1.2323607   7629.04    6190.59 0.98669165
Molecular Medicine




                     63874.96   0.9121842   36679.22   40210.32   1.643114     42293.8    25740.03 0.80243474    27375.23   34115.21   0.718097     46288.2    64459.54    0.93425    12577.9    13463.1    1.1981013

                     63874.96   1.1714202   56985.88   48646.83   1.1626148   48732.78    41916.53   1.3514241   19029.66   14081.19   3.8983138   224629.77   57622.29 0.86010927    16960.28   19718.75   1.0446637

                     8620.13 0.62561506     1676.98    2680.53    0.5227056     998.42     1910.1    1.2517825   3890.39    3107.88 0.78853524      6562.08    8321.86    1.2660913   2068.54     1633.8    1.1275637

                     19975.55   0.921483    7205.26     7819.2    1.3588119   22426.92    16504.8    0.9046461   8642.79    9553.78 0.71448916      3161.05    4424.21 0.81344664     3689.55     4535.7    1.0876054
                      195.67    0.726927     309.62     425.93 0.53231573      1204.21    2262.21    1.3575742    303.54     223.59     1.35345      201.84     149.13                                      1.320617
                      175.65 0.95116997      107.72     113.25                                       1.0300014    144.88     140.66    1.043804      334.32     320.29 0.96406394      211.13       219     0.5568115

                      564.52 0.89423925      527.78      590.2    0.9053437    5495.02    6069.54 0.90267646     1670.15    1850.22    1.4095862    1682.75    1193.79    0.7873262    354.47     450.22    0.8547494
                     12250.83 0.94313127    3247.55    3443.37    2.301443     9786.22    4252.21    1.3182251   4286.42    3251.66    0.8931526    5676.78    6355.89    1.060731    2288.05    2157.05    1.2595103
                     29266.71   1.0000644   15842.65   15841.63   11.567641   148360.67   12825.49   3.414653    14802.52     4335     3.6400535   30092.14    8266.95    3.215033     9082.5    2825.01    1.9646789

                     18376.04   0.6595982   28852.48   43742.51 0.32988575    12959.34    39284.33   0.8424909   13723.52   16289.22 0.52538043    12284.12    23381.38   1.0040145   16764.15   16697.12   0.9235784
                     53691.44   1.1059638   36317.05   32837.47   2.0755658    53095.09   25581.02   1.1848791    33426.33   28210.75 0.89540756     25832.23    28849.69 0.97141534    28396.85   29232.45   1.1879293




                                                                                                                                                                                                                    UNCORRECTED PROOF
                     8344.31    1.6191226   7445.94    4598.75     9.633505    68097.8    7068.85    1.5729914    5072.96    3225.04    1.2554898     8020.86    6388.63    1.9316528   6784.37    3512.21    1.6095862
                     27286.68   0.9098215   8427.94    9263.29    1.6177096    8644.62    5343.74 0.98845434      42688.34   43186.96 0.99490803      37028.5    37218.01   1.1207138   11284.4    10068.94   0.8116639
                      334.56    1.3808782    602.56     436.36     1.828663    9923.35    5426.56    0.9778157    1250.46    1278.83    0.7603343     1513.05    1989.98    1.8610064    444.52     238.86 0.88191396
                     14772.98   1.1462632   10376.64   9052.58 0.44569772      9189.03    20617.18 0.95602846      5968.4    6242.91    0.5835015     7338.92    12577.38   0.446211    3681.04    8249.55 0.45956203
                      579.33 0.84061015       92.03     109.48     1.080289     985.04     911.83    1.1630992     572.71      492.4    0.9977576      551.74     552.98 0.98136514      475.02     484.04    0.9440735
www.molmed.org




                     28410.06   1.1023258   18083.72   16405.06    1.081907    34113.07   31530.5    1.2815552    23774.08   18550.96 0.95198584     25652.96    26946.79   1.1256038   12177.13   10818.31   1.008339
                     6910.04    2.4455009   3174.04    1297.91    4.1774697    24181.66   5788.59    1.6953115    3421.02    2017.93     1.433087     5239.71    3656.24    1.9096833   2860.19    1497.73    1.5248978
                      290.07    23.51897     173.57       7.38    0.07029851    146.72     2087.1    0.8487131     637.74     751.42    1.2359257      972.76     787.07    1.0278021    329.76     320.84    1.7864554
                                1.6052309   1376.02     857.21    1.0773238    5416.45    5027.69    1.1398886    1195.31    1048.62 0.97747517        458.69     469.26    1.2735192    880.04     691.03 0.84070736
                     4281.06    0.861411    1888.54    2192.38 0.74383235      8231.07    11065.76    1.143978    2588.01    2262.29    1.2174563     5418.18    4450.41    1.0949671   1394.55     1273.6    1.281515
                     3164.43    1.0198973   1822.22    1786.67    0.9965998    2866.53    2876.31     0.940327    1332.18    1416.72    1.2196662      1853.6    1519.76    0.7632853    636.87     834.38    1.0200744
                     62143.59   1.0943266   24179.75   22095.55   0.8963584    39272.93   43813.87   1.5093616    23989.31   15893.68   1.5214247    49537.89    32560.2    1.460973    30898.82   21149.48   1.179329
                      4776.2 0.88542175      870.83     983.52    0.8930558    1580.03    1769.24    1.1641322    1152.91     990.36 0.94358534       2368.22    2509.81    1.4213545    604.63     425.39 0.76827013
                     5962.25 0.58382356     3191.74    5466.96 0.40709767      2464.85    6054.69    1.2846713    1321.49    1028.66 0.89734757       6975.02    7772.93    1.0623195   1666.11    1568.37    1.1441581
                     38983.02   0.7176666   15070.87   20999.82 0.26039115     9211.62    35376.09   1.0259188    10923.06   10647.1    0.8323958    35544.89    42701.91   1.2093174   12958.03   10715.16   1.4259081
                     31845.62 0.32530773    5786.72    17788.45   1.8131061    12351.44   6812.31    19.406126    12614.37    650.02     5.824581    11990.25    2058.56 0.27135372     3794.67    13984.22   0.7672079
                     61351.23   0.9851456   39874.26   40475.5    0.5996303    26181.25   43662.32   1.5525053    59800.84   38518.93    1.238447    65022.02    52502.87   1.2797005   37002.13   28914.68   0.8626086
                     51894.61 0.79214215    11228.37   14174.69   2.6083841    19103.83   7324.01     14.06392    76549.22   5442.95     8.747902    39816.25    4551.52    1.1197149   3923.66    3504.16    1.5210601
                     43544.01 0.66286427    16356.15   24674.96    0.335924    7040.13    20957.51   3.6113045    24786.08   6863.47     3.567909    32598.13    9136.48    0.5283107   2810.56     5319.9    1.2029909
                     63874.96   1.0764512   47193.48   43841.73   0.4692393    61490.9    131043.8   1.4570378    94175.64     64635     2.295297    146847.22   63977.44   1.2902344   51463.98   39887.31   1.6548303
                     14930.42   1.218833    19339.26   15867.03   1.6375479    54870.23   33507.56 0.92595154     13398.89   14470.4    2.0208635    34151.32    16899.37   0.9055167   9431.78    10415.91   1.1100379
                                                                                                     0.26965213     92.55     343.22    1.6237441      193.94     119.44
                      889.94    1.200227     919.77     766.33    1.0214354     999.26     978.29    1.0209614     456.87     447.49    1.5315541      629.53     411.04                                      1.8846326
                     5511.94    0.8485355   3693.59     4352.9    1.0050367    6301.58      6270     0.7488838     1504.5    2008.99 0.89351475       3048.02    3411.27    0.931016    1446.38    1553.55 0.53638154
                                                                  0.2040477     204.97    1004.52
                     1149.72    1.3753122   2537.96    1845.37    1.9681687    5332.34    2709.29     0.622408     1164.6    1871.12    1.4749966     1258.88     853.48    0.9388953   1235.99    1316.43    0.9248942
Molecular Medicine




                      378.41    1.7741697    503.19     283.62    2.2802417    3167.21    1388.98     1.221407     206.43     169.01    1.1274061      844.01     748.63    1.0370878    348.14     335.69 0.53976256
                     24706.03   0.8351775   14267.27   17082.92 0.51786745     10965.45   21174.24 0.80354035     12101.27   15059.94   1.2871736    13360.36    10379.61 0.69957376     3492.3    4992.04 0.96013314
                     22964.47   1.1935673   17828.9    14937.49   1.6283803    41591.91   25541.89     1.09177    15290.01   14004.79   1.2111777     31039.7    25627.7    0.980777    15993.57   16307.04   1.0052578
                      456.38    0.851371     386.88     454.42    1.3255537    1301.76     982.05    1.0633079     442.57     416.22 0.87481964        927.37    1060.07 0.84454745      415.34     491.79 0.76717556
                     2550.82    1.0957271   1998.65    1824.04    2.6170943     4335.4    1656.57 0.58966446      1043.14    1769.04 0.54717505       2952.42    5395.75    1.7998034   2507.81    1393.38    1.298251
                     31029.91   1.0994043   19174.38   17440.7    0.5430828    8316.71    15313.89   1.8625492    9727.35     5222.6    4.3533325    57606.04    13232.63   1.2327529   18054.48   14645.66   1.2517117
                     58824.04   0.9891238   41062.38   41513.89   0.5748562    23512.43   40901.41   1.1670167    54269.3    46502.59    1.569895    72452.46    46151.15   0.7746669   20138.65   25996.53   1.1021538
                                                                                                                                        0.11512457     101.99     885.91
                     4448.32    0.8877105   4216.51    4749.87    0.8339968    3752.36    4499.25      2.10408    6264.33    2977.23    2.5675309     4213.96    1641.25    2.2705176   2883.58    1270.01    1.5092932
                     6449.47    1.0392996   4111.49    3956.02    0.8164198    5299.25    6490.84                                       0.3312204     1243.09    3753.06    0.5496852     697.6    1269.09 0.54731154
                     1460.77 0.97995895     3149.49     3213.9 0.47989726      2725.73    5679.82    0.8338417    1563.57    1875.14    1.0144737     1874.94    1848.19 0.98067135     1829.56    1865.62    0.9959821
                                1.0614598     819.5     772.05 0.26813826      4604.81    17173.27   1.1394913    1504.14    1320.01     1.957792      417.46     213.23    1.7375487    672.97     387.31 0.90042794
                      784.96    1.0279716     782.05     760.77 0.63230824      6836.08    10811.31   1.0174346   1251.18    1229.74    1.0701334    1342.75    1254.75    1.1444008    670.39      585.8    0.9001178




                                                                                                                                                                                                                    UNCORRECTED PROOF
                                0.6546375     565.07     863.18 0.37133518      8154.48    21959.89   1.3886431    420.62      302.9      1.94572     367.78     189.02                                      1.0764186
                      188.01    1.1276362     708.99     628.74 0.93158275      1669.89    1792.53    1.102893     245.89     222.95    1.3409066     368.87     275.09    6.0266027    226.54      37.59    1.1067706
                     7772.62    0.6814623    1808.56    2653.94     1.100218    1826.12    1659.78    1.1687771    959.94     821.32     1.016013    2980.84    2933.86    1.9575036   1789.08     913.96    1.1241988

                     2453.08 0.97106546      1670.32    1720.09    1.0678324    2180.77    2042.24    0.667272     635.77     952.79    1.0897412    1190.15    1092.14    0.6584768    333.13     505.91    0.7518371
www.molmed.org



                      614.37    0.8422535     442.36     525.21    1.1019678     563.91     511.73    1.1263249    158.35     140.59 0.05532503         10.8     195.21 0.40060145       50.62     126.36 0.11798931

                     6132.06    1.9978306    15074.69   7545.53    5.3753023    58829.94   10944.49   1.2787523   6134.29    4797.09    1.3288659    10966.28   8252.36    1.4660348   3037.58    2071.97    1.2660022

                     13147.6 0.74100286      4269.31    5761.53    1.6720618    3200.46    1914.08    0.7453655   1002.77    1345.34 0.77122134      1756.31    2277.31    0.9583502    855.96     893.16    0.8149969
                     1939.98     0.919102    1003.88    1092.24 0.85096246      4619.62     5428.7 0.85790306      926.99    1080.53 0.77417207      1220.25     1576.2    1.019994      738.7     724.22 0.85296845
                     15124.86   1.3262843    13788.78   10396.55   1.7243159    14249.85   8264.06 0.64032316     4730.08    7387.02 0.98071545      11996.16   12232.05   1.0194275   8022.63    7869.74 0.97654396
                      384.41    0.8115234     309.02     380.79    1.1310825     570.88     504.72    1.223616     443.83     362.72    0.7350461      344.2     468.27    1.1447531    701.23     612.56     1.228305
                     44236.45   0.8302405    29429.86   35447.39   2.0318072    73534.05   36191.45   1.1111804   27384.24   24644.28 0.93437475     37613.17   40254.91   1.3630499   55018.16   40364.01 0.88482904
                     34763.84     1.15782      7581     6547.65 0.07749112       580.61     7492.6    0.8021641   6084.15    7584.67    1.6283896    38695.47   23763.03 0.68612534    4278.06     6235.1    0.6688593
                     5353.72 0.82594687      3975.15    4812.84    1.0308583    8095.65    7853.31    1.0691042   6815.24    6374.72    1.2609379    17194.01   13635.89   0.9618751   3721.86    3869.38    1.0764701
                     4216.79    1.1973051    7950.68    6640.48    3.0648203    35919.02   11719.78 0.52590877     1870.2    3556.13 0.89393455      2722.12     3045.1 0.38615015      413.59    1071.06 0.85560703
                      773.17 0.94167703       517.96     550.04     2.170853     895.39     412.46    0.6847778    324.66     474.11    1.0996948     378.46     344.15 0.029528752       4.38     148.33    1.7927026

                      417.37    1.5327429     465.54     303.73    0.7769911    1676.91    2158.21    0.7014055    406.71     579.85 0.91457295       626.83     685.38    0.0672708     16.48     244.98 0.78909725
                                0.6193146     513.61     829.32 0.58456385        893.5    1528.49    1.353586     405.02     299.22     8.294443     134.37       16.2    1.4758693    251.68     170.53    0.9874066
                                1.1849337     703.27     593.51 0.73502594      1485.98    2021.67    1.1144127    316.17     283.71     0.758432     328.53     433.17    2.559112     268.63     104.97 0.85072917
                     34386.82   1.0042782    18103.63   18026.51   0.3968355    3030.74    7637.27 0.61223644     5084.03    8304.03    1.4162819    64407.09   45476.18   0.8485349   9549.59    11254.21   1.2144898
                     2806.92    1.3097653    3749.02    2862.36    1.1733558    4208.44    3586.67    1.7692504   4936.58    2790.21    1.7915664    5039.73    2813.03    1.614726    6933.31     4293.8    1.1625367
                     3883.89     0.755262    1825.71    2417.32    0.5714154    1490.48     2608.4    1.4153014    641.91     453.55     0.609609    2707.92    4442.06    1.4463189   1772.97    1225.85 0.97851074
                     1579.59    0.9947323    2054.52     2065.4    1.5753953    3982.71    2528.07    1.0137581   1635.81    1613.61 0.76236504      1189.32    1560.04 0.79085195     1080.28    1365.97 0.86681867
                     5595.25    0.9578455    2008.42    2096.81    1.0737813     3398.7    3165.17 0.97097117      698.74     719.63    1.0178102    3246.56    3189.75    1.337029     683.77     511.41    0.7174353
                     12454.44   0.9792317    18035.54   18418.05   1.8581291    51772.94   27862.94 0.71078026    11946.19   16807.15   0.8643616    9527.59    11022.69   1.0354128   4386.34    4236.32 0.99677104
                                                                   0.76368064   1482.35    1941.06                                                                                                           3.3656604
Molecular Medicine




                     33783.61   1.3033855    23511.29   18038.63 0.81424546       16280    19993.97 0.63433117    40565.86   63950.6    0.7489622    30799.31   41122.65   0.9552883   16781.31   17566.75   1.0697811
                     1367.97    1.0186932    1239.77    1217.02    1.4203085    2560.66    1802.89 0.91229916      469.98     515.16    1.3230234     760.54     574.85 0.33972177      106.71     314.11    0.94198346
                     5978.25    0.7309512    2219.27    3036.14    1.0755038    2266.85    2107.71 0.68133795     4738.31    6954.42    1.5280343    11262.53    7370.6    1.0271086   1794.41    1747.05     1.260022
                                0.34850532    116.23     333.51    0.7143057      255.4     357.55    0.5281268    139.98     265.05 0.10255428        29.43     286.97    0.8194107    148.51     181.24    0.6637061
                     20274.3    0.8156824    17350.07   21270.62   0.9466579    30377.75   32089.47   0.764237    12044.91   15760.7 0.92484057      7673.06    8296.63    0.8467449   3021.44     3568.3    0.7002009
                     7173.68    1.1998605    5671.74      4727     1.0704261    5029.14    4698.26    0.6216252   2129.98    3426.47 0.79245263      2275.71    2871.73 0.72726196     1109.46    1525.53    0.9874911
                     14065.81   2.3490481    11796.31   5021.74    3.7086256    44375.52   11965.49   0.6961552   6803.74    9773.31    1.8092288    12150.69   6715.95    2.3013687   16390.14   7121.91    1.4562325
                      3570.9    0.7687582    2775.44    3610.29 0.76277447      4267.83    5595.14 0.91653264       951.7    1038.37    0.8984434    1919.65    2136.64 0.12863456      142.41    1107.09    1.1840293
                       679.8    0.5738402     658.78    1148.02 0.12612097       280.99    2227.94    0.5770222    597.87    1036.13 0.83225924       732.23     879.81 0.97727513       92.03      94.17    0.9091611
                     18194.02 0.95917594     21098.84   21996.84    1.024125    36691.86   35827.52   0.8114486   14882.9    18341.15   1.1067123    17736.35   16026.16 0.75880146    3753.73    4946.92 0.91174436
                                0.13561602     22.18     163.55                                       1.3483114    143.73      106.6    0.15908018      10.1      63.49    1.3822653     92.75       67.1     1.695747
                     24724.9    1.1760988    14119.96   12005.76   1.7671903    22369.89   12658.45   1.0442512   4792.57    4589.48    1.4490129    12613.57   8704.94    1.2076486   4330.29    3585.72 0.80325425
                     27774.67   1.2461605   27481.84   22053.21   1.7545168   27339.32   15582.25 0.84052294    5927.57    7052.24    0.6476475    22774.11   35164.36   1.2616719    6312.17    5003.02    1.1607792




                                                                                                                                                                                                                   UNCORRECTED PROOF
                     38175.34   0.7939505   29107.71   36661.87   0.3624176   14127.66   38981.72   0.8683181   11412.8    13143.57 0.97220284     38966.29   40080.41   1.2788695    12256.8    9584.09    0.7581062
                     1752.91    1.4684745   19044.28   12968.75   0.6646375   17596.95   26476.01   1.2367069   11238.66   9087.57 0.47913656      4852.81    10128.24 0.82570547     10619.34   12860.93 0.88338464
                     1265.88    1.0773046    810.37     752.22    1.7843553   1010.07     566.07    1.0727133   2143.12    1997.85    0.7732302    2576.38    3331.97    2.0804996    1092.72     525.22    1.3618344
                      368.35    0.9167688     82.28      89.75                                                                        1.0079652     365.72     362.83 0.14279945        17.68     123.81
                     36883.18 0.90737194    15758.5    17367.19 0.35915813    3955.43    11013.06   1.2522228   2245.01    1792.82    1.0897752    30346.84   27846.88   0.7441104    4461.47    5995.71    0.8182579
www.molmed.org



                     4855.78    1.235821    8696.46    7036.99    1.0175962   12268.63   12056.48   0.6864963   8253.91    12023.24   1.1525875    9186.33    7970.18 0.75251335      3490.33    4638.23     0.837204
                      517.19    0.9826135    482.08     490.61    0.6131272    560.76     914.59    1.1375388    432.06     379.82     2.408742     668.45     277.51                                       1.5552006
                      393.99    1.1553048     99.31      85.96    1.7020627    385.33     226.39    2.0967615    213.01     101.59 0.56778723       285.79     503.34 0.17950882        46.78      260.6    0.95021695
                       73345    1.8061291   14811.92   8200.92    1.077802    4806.22    4459.28 0.66566473     5642.54    8476.55 0.76499796      10660.04   13934.73   1.2338545    1482.76    1201.73    0.7536735
                      154.68 0.77499884      497.34     641.73 0.68587935     1053.25    1535.62 0.38002235      183.68     483.34 0.28929865       243.52     841.76                                       0.4193935
                     11678.6    0.7891584   20052.76   25410.31 0.30445522    8998.43    29555.84   0.5975877   4906.96    8211.28    0.7104743    5853.96    8239.51    1.2869291    8118.94    6308.77    1.1559567
                     12055.59 0.74308014    4457.47    5998.64    0.8340329   4144.81     4969.6 0.92932814      3775.6    4062.72     2.254405     7809.8    3464.24    1.4508034    3731.06    2571.72 0.95318156
                     44037.27 0.81916535    30835.71   37642.84 0.09226779    6100.72    66119.71   0.5996139   21109.55   35205.24   1.2022427    35051.35   29154.97   0.8865934    10838.32   12224.68   1.2427557
                     63874.96   0.9501498   61033.43   64235.59 0.74086016    47650.85   64318.28   0.4360026   28181.03     64635    1.0259796    66134.17   64459.54 0.42604157     49314.48   115750.4 0.96987855
                      393.33 0.86879855       768.6     884.67    0.6257245   2028.48    3241.81    0.9424117    308.31     327.15    0.5968883     355.25     595.17    1.2887208     211.26     163.93    1.1427552
                                0.8539292    797.92     934.41    0.3816228     252.1      660.6    1.1479874    385.85     336.11                                       0.84358984    209.05     247.81    1.1753218
                     12873.96 0.80003846    8819.84    11024.27   0.3478823   2303.28    6620.86    1.4479816   13910.18    9606.6    1.0078286    9892.17    9815.33     1.844491    14717.82   7979.34    1.5851424
                     12897.89 0.84842736    8175.31    9635.84    1.7275442   23861.67   13812.48   0.8511223   14731.37   17308.17   0.5163197    5298.71    10262.46   0.8524546     3946.2    4629.22     0.841339
                       23099    1.0478169   14503.39   13841.53   1.645548    23229.74   14116.72 0.88173413    6170.79    6998.47    1.0302317    12966.96   12586.45   0.7157845    6000.98    8383.78    0.6535319
                     21247.08 0.99509484    4418.41    4440.19    3.400974    4267.61    1254.82    1.1213303   1102.29     983.02    2.0413358    25493.08   12488.43   1.0922163     1089.3     997.33    1.5323713
                      1330.8    1.1133587   7494.24     6731.2    1.3795694   14852.21   10765.83 0.86641425    3267.95    3771.81    0.9196026    2414.15    2625.21 0.88775706      1749.05    1970.19    1.1838489
                     7849.23    0.6814388   2850.22    4182.65    1.0272255    3023.7    2943.56    1.1616747   2283.26    1965.49    0.8993344    3276.32    3643.05    0.4637945    1436.52    3097.32    0.6780863
                     1849.82    1.0723835   11425.11   10653.94   1.9243339   49547.94   25748.1    0.8820665   7516.23    8521.16    1.3199188    8853.87    6707.89    1.2382131    2680.31    2164.66 0.88900334
                       171.5    0.8597123    150.57     175.14    1.4198211    471.48     332.07    0.9101706    261.31      287.1    1.1083713    1288.67    1162.67    1.2506778     161.45     129.09    0.3906105
                     3356.63    0.7350301   3249.59    4421.03    1.6406677   5658.63    3448.98    0.6294614   2045.97    3250.35 0.66981465      2814.34    4201.67 0.75456583      2197.62    2912.43    1.0393897

                     16457.92   1.0035837   4993.15    4975.32    1.2974585   2555.63    1969.72    1.0378199   1673.36    1612.38 0.82904804      2000.75    2413.31 0.82623553       595.03     720.17    0.7198591
Molecular Medicine




                                                                  0.7372851    833.11    1129.97    0.9472574     40.41      42.66    0.6828326     236.82     346.82                                       1.1951867
                     63874.96   1.0584711   34920.7    32991.64   1.098323    52236.63   47560.35   1.1092969   17441.93   15723.41   1.2694638    81465.31   64173.01   1.3682951    39777.28   29070.69   1.1991729
                     74895.53 0.84520423    15149.66   17924.26 0.93135536    16664.63   17892.88   1.1299247   13631.31   12063.91   1.1171124    56656.23   50716.68   0.8310268    11836.34   14243.03   1.1168361
                     3424.16    0.7736297   1701.73    2199.67 0.20360918      560.98    2755.18    0.9587906    549.55     573.17 0.98088306      3196.58    3258.88    1.6729567    1268.67     758.34    1.1333762
                     4001.08    0.3512237   1012.29    2882.18                                      0.8151928   3661.52     4491.6    0.5994445    4637.77    7736.78 0.77735597       790.33    1016.69    0.7313058
                      700.56    0.6679394   1373.25    2055.95 0.91252536     1085.75    1189.83    2.0517373   1608.48     783.96    1.0500468     706.86     673.17 0.27845907       189.38      680.1    0.6518434
                      478.82    0.8743122     406.8     465.28    1.5163324    1089.5     718.51 0.06847113       35.77     522.41    0.3406314     210.19     617.06                                       0.68921465
                     19403.22   1.845708    2091.87    1133.37    2.339844    2198.26     939.49    1.8301271   1623.03     886.84    2.2935646    21166.69   9228.73    1.4150705     267.42     188.98    1.0530773
                                0.5146203    220.17     427.83    0.5140633    128.12     249.23    0.9771473    566.55      579.8    0.51435477    119.14     231.63    0.2580698      62.84      243.5    0.6309839
                                                                                                                                      0.11801136     49.35     418.18
                     32452.98 0.86200595    11877.58     13779    1.4977422   33743.92   22529.86 0.88848865    17881.27   20125.49   1.8502207    29934.11   16178.67   0.5498567    7770.96    14132.7    0.9308174
                     27284.43   0.9705723   10552.11   10872.05   2.2919273     25285    11032.2    7.5734425   13732.47   1813.24     3.006588    22955.99   7635.23    1.0070609    5548.16    5509.26    1.1606097
                     27931.38   1.1040579   11714.86   10610.73   2.8988674    36207.78   12490.32   1.2490996     8740.8    6997.68    1.9082168    27199.76   14254.02   1.5761462    9625.1    6106.73       1.321




                                                                                                                                                                                                                   UNCORRECTED PROOF
                     53645.35    1.40826    23849.15   16935.19 0.44444218      3012.1    6777.26    1.4075632    90977.85     64635    1.3475015    86859.33   64459.54   0.976671    6145.79    6292.59    1.1550721

                     1203.67 0.81846946     1034.93    1264.47 0.68490326      1219.71    1780.85    0.5436983     581.73    1069.95    0.6843405    1342.06     1961.1    0.6104037    760.27    1245.52    0.4413759

                      1965.2 0.81393033      948.88     1165.8    0.3383979     814.95    2408.26 0.72072124       126.71     175.81    1.3117622    1705.96    1300.51    1.0234945    334.13     326.46    1.093088

                     25481.91   1.0320361   15241.49   14768.37   1.3274993    26610.16   20045.33   0.7029319    10147.89   14436.52 0.71496516     13832.26   19346.76 0.89052826    14674.23   16478.12 0.94673884
www.molmed.org




                     38748.43 0.41027808    9897.93    24124.93   0.6368735    8955.76    14062.07   1.1892724    6678.93    5615.98    0.9642109    26270.38   27245.47 0.78774035    16547.99   21006.91   1.1374391

                     63874.96   1.0749886   69052.52   64235.59   1.4926282    96003.28   64318.28 0.80981094     52342.13     64635    0.64910007   41840.69   64459.54   1.2000711   77326.58     64435    0.8950866
                     28115.26 0.60051656    12383.3    20621.08    0.497949     1308.6    2627.98 0.59376556      1493.73    2515.69    0.7955985    2076.87    2610.45    0.7283645    695.61     955.03    0.9526797
                     2334.42    1.0219721   1633.98    1598.85    1.2259434    6563.37    5353.73 0.91396534       344.83     377.29    1.3638408    1558.42    1142.67        0.01       0.07     764.07    1.3909092

                      749.46    1.1536582   1165.61    1010.36    1.9014856    17648.62   9281.49    1.1869503    1086.57     915.43     1.114877     668.09     599.25    1.0205053    672.86     659.34 0.70626104

                     35212.98   0.8882713   19012.31   21403.72   1.1014955    35551.25   32275.44   1.1038536    16995.03   15396.09   1.0962874    31221.53   28479.33   1.0287827   11491.74   11170.23   1.2145857
                     5435.69    1.7477452   13094.09   7491.99    2.3088193    35851.85   15528.22    0.794021    5960.43    7506.64 0.97800726      9632.53    9849.14 0.94254273     6314.65    6699.59    1.1845803
                       383.8    2.2282302    244.37     109.67    2.1358643     968.23     453.32    1.2283413     590.39     480.64    1.3590146     527.42     388.09    1.3877774    686.02     494.33    1.314771
                                                                                                     0.51194614    181.06     353.67 0.91790885       332.54     362.28 0.35005498       19.12      54.62

                     42968.48   0.8412146   17813.2    21175.57   1.1686621    34140.37   29213.21   1.0335854    18080.23   17492.73 0.92975694     43344.99   46619.7    0.6604135   17936.95   27160.18   0.8317989
                     14551.79    1.49553    3758.88    2513.41    3.2316847    14463.34   4475.48    1.1568905    30606.21   26455.58   1.2057782    15891.94   13179.82   1.1819063   11032.6    9334.58    1.4476987
                      6931.1    1.3404242     4184      3121.4    1.4889086    10653.35   7155.14    1.8986537    6443.86    3393.91    1.5544904    5006.05    3220.38    1.675756    2302.12    1373.78    1.1670349
                      1946.6 0.51723355     1003.79    1940.69    0.5298855     1159.4    2188.02    0.9755462    1632.44    1673.36 0.97840154      2203.82    2252.47 0.19554271      106.78     546.07    0.9657091
                     1793.06    0.9989315   1664.13    1665.91    1.4941647    3461.92    2316.96     5.513453      98.36      17.84    0.74652296    545.35     730.52    1.2910266    217.68     168.61    0.7642725
                     5629.09    1.1496896   5174.96    4501.18    0.6865332    10836.57   15784.48   0.5073336    2713.92    5349.38 0.67808807      3064.68    4519.59 0.36087644     1545.06    4281.41    0.6840879
                     14920.92   1.0064986   9947.88    9883.65    1.2178683    14103.28   11580.3    1.1940155    7280.45    6097.45    0.6880939    11219.9    16305.77 0.92379105    6705.79    7258.99    1.038085
                     1832.93    0.9122249    438.99     481.23    1.9775287    1395.72     705.79 0.69631827       444.07     637.74    1.0491481    3136.68    2989.74    1.3372107    240.27     179.68    1.2474568

                      484.39    0.6665771     74.43     111.66    28.811628     143.77       4.99    0.8632289     213.77     247.64    1.2235478       684      559.03    0.859749     184.27     214.33    1.1601423
                                                                  0.99933445    330.34     330.56 0.88295805      1025.75    1161.72 0.11974975        61.44     513.07    1.5978035    692.52     433.42    1.0124103
Molecular Medicine




                      404.45    1.7697934    430.75     243.39    1.8145849    3078.57    1696.57    1.3430862    1025.03     763.19    1.0128461     406.84     401.68    4.474564     321.05      71.75    1.1665463
                     6039.19    1.003157    6825.27    6803.79    0.9022338    12601.31   13966.79   1.6452001    6501.37    3951.72    1.5643779      5415     3461.44    1.4941261   4350.94    2912.03    1.0978762
                     2258.71    1.2286894   4009.14    3262.94 0.97218764      6813.47    7008.39    1.1668406     2650.7    2271.69    0.9685637     1973.4    2037.45    1.3566402   2778.25    2047.89    1.1065562
                      466.92    1.1889062   1229.65    1034.27     1.379867    9340.83    6769.37    1.1524392    3474.42    3014.84    1.1822231      1383     1169.83    1.4455285   1317.18     911.21    0.8391267
                     13600.61   0.9930069   6405.48    6450.59    0.5235365    8892.64    16985.71   0.8656062     3679.9    4251.24 0.63081384      7114.47    11278.24 0.52937037     2713.6    5126.09    0.6865773
                     2095.95    1.0217739   2130.46    2085.06    0.7222526    4504.09    6236.17    1.1762346    2322.64    1974.64    0.9201091    2154.73    2341.82    1.151011    1991.79    1730.47    1.0090628
                      261.81    1.601182     390.16     243.67     2.386407     386.24     161.85                                       12.056903     144.08      11.95    1.9732715    123.29      62.48    1.3704168
                      766.01 0.85687685      975.46    1138.39    0.5787782     1876.7    3242.52    0.7879169      663.3     841.84    2.6687257    2030.66     760.91 0.90499085       696.3      769.4    1.501772
                     4574.59    1.6261449   9143.13    5622.58    1.9166254    21800.1    11374.21   1.0167488    5733.07    5638.63    0.7869218     4152.5    5276.89    1.0425351   5105.92     4897.6    1.0825545
                      750.67    0.9307752     323.1     347.13    1.4492227    1066.57     735.96     1.146346     432.78     377.53    1.0809956      751.8     695.47    1.6262835    430.77     264.88    1.2266526
                      173.22                                                                                                            1.0086248     105.25     104.35
                      843.55    16.572674     646.5      39.01    1.1733599     1579.8    1346.39    0.8866214     854.57     963.85    1.0860442    1491.66    1373.48    1.404339      507.5     361.38    1.1463934
                     22141.89   0.9692424    7795.5    8042.88    1.6843758    7761.57    4607.98    0.9331388    14775.73   15834.44    2.100014    41385.37   19707.19 0.61193174    4078.99    6665.76 0.85042065
                     38419.44 0.96657544     18093.49   18719.17   2.0089743   30709.38    15286.1    1.1018916    13191.55   11971.73   0.8950187   35241.17   39374.79 0.88318336     11629.75   13167.99 0.84162694




                                                                                                                                                                                                                    UNCORRECTED PROOF
                     2769.52    1.1087681    2177.92    1964.27    0.5040677    4364.43    8658.42    0.6766427    3639.81    5379.22    0.6584528   1757.72    2669.47    0.6934689    2082.73    3003.35    0.8810941
                     1559.26    1.0436366    1203.72    1153.39 0.016617283        12.9      776.3    0.7116607    2320.69    3260.95 0.44184905      801.66    1814.33    1.5289819    1517.27     992.34    1.6121176
                     18927.14   0.9375984    11289.22   12040.57   1.3546783   16539.62    12209.26 0.88991004     2792.68    3138.16    0.693769    10120.3    14587.42   0.9218962    2776.06    3011.25 0.72169036
                      434.34                                       0.8891922     110.74     124.54    0.8749528     231.81     264.94    1.1914492   1190.77     999.43    1.0049653     208.47     207.44 0.97934705
                      887.68    1.7387029    1170.46     673.18 0.69729316      3340.09    4790.08    0.6225958     382.94     615.07    0.7846308    1407.4    1793.71    1.1745399     545.01     464.02    1.0513756
www.molmed.org



                     13487.28    2.410679    23952.87   9936.15    2.9321754   104973.26   35800.47 0.69765025     17125.94   24548.03 0.87357897    18018.23   20625.76   1.0162067    25524.28   25117.21   1.5461388
                     67558.71   0.7067037    30279.79   42846.51   1.2109284   51648.22    42651.75    0.937171    58801.07   62743.16   0.8385228   37281.38   44460.78 0.51646066     21768.6    42149.58   0.6765592
                     1502.17    0.6746451    1221.31     1810.3    0.6173551    2696.57    4367.94    2.5621252     277.76     108.41    1.2008554   1695.92    1412.26    1.0981025     193.87     176.55    1.0875037
                     9639.97    1.1143458    5675.33    5092.97 0.11419637       792.09    6936.21    0.6833273    10968.88   16052.16   1.2539489   12118.15   9663.99    0.3510544    1613.26    4595.47 0.58695215
                     1141.83 0.85754746      1389.81    1620.68 0.76992345      3495.46    4540.01    1.3361018    1441.44    1078.84    0.7691469    994.83    1293.42    1.1192712      652.3     582.79    0.9087265
                     8054.31 0.98355585      4775.98    4855.83    0.7820347    7306.12    9342.45     1.189808       5511    4631.84    1.3801885   6551.52    4746.83    1.2366096    5372.92    4344.88    1.1278872
                     32985.4    1.3236861    6034.42     4558.8    2.4898114   20610.36    8277.88    1.3308978    2315.07    1739.48    1.0985411   19414.43   17672.92   1.3926047     2118.5    1521.25    1.2891334
                     8477.34    2.3583298    10334.39   4382.08    1.1400416    9356.55     8207.2     2.090185    7980.66    3818.16    1.803701    4643.34    2574.34 0.68026626       2925.9    4301.11    0.9216877
                     1662.19    1.4968954    1509.17     1008.2    3.1019394    3887.04     1253.1     1.011695    3745.73    3702.43    1.8900713   5177.34    2739.23    1.7548083    1690.67     963.45    1.3708329
                     3137.64    0.9999376    1762.54    1762.65    1.6220521    2420.28    1492.11    1.0352292     413.16      399.1    1.2343527   1811.82    1467.83    0.8418185     789.39     937.72    1.0772216
                     37776.91   1.4310764    10485.11   7326.73    2.561565    24370.24    9513.81    1.0433757    17897.17   17153.14   1.395487    28688.84   20558.3     1.010527    17060.15   16882.43   1.0532147
                     36220.68   1.5563246    17203.16   11053.71 0.97922873    25804.41    26351.77   1.3054714    21252.5    16279.56   1.0328906   23682.58   22928.45 0.91354626     14151.8    15491.06   0.7148504

                     13464.94   1.3161995    3837.59    2915.66    2.0728805    31392.2    15144.24   0.7229607    3536.63    4891.87    1.8898703   17601.42   9313.56    1.0692384    5583.21    5221.67    1.0142124
                       292.8    0.87193716    306.39     351.39    0.5121213     126.96     247.91                                       0.4623956    188.81     408.33
                     3580.29    0.5374964    1311.33     2439.7 0.54264003      1793.04    3304.29    1.7001175    2924.78    1720.34 0.83132374     1420.99    1709.31    1.0333779    1004.65      972.2    1.9783072
                     63874.96   1.1822705    32486.05   27477.68   1.8573067   24030.02    12938.1    0.7044463     7975.1    11321.09   1.1117446   10373.8     9331.1    0.9380475    4858.72    5179.61    1.1369661

                     4669.52    0.8044539    3585.25    4456.75 0.30593783        6857     22413.05 0.45322406     2171.17     4790.5    1.1596056   2623.48    2262.39    0.5293111     643.15    1215.07 0.84213597

                     9875.11    0.8612715    5248.89    6094.35    1.9401134   14851.84    7655.14    1.1791856       4476    3795.84 0.55056405     5707.24    10366.17   1.1562641    3770.08    3260.57    0.8413958

                     35409.26 0.79472023     22446.54   28244.58   1.7411628   67600.47    38824.9    0.9242065    14917.82   16141.22   1.0885566   30913.19   28398.33 0.77374333     7309.19    9446.53    1.0010648
                     36606.4    0.8817408    19195.78   21770.32   1.0312202   29609.93    28713.49 0.79201317     10527.55   13292.14   1.2850183   43482.04   33837.68 0.80957836     11686.79   14435.65 0.94097483
Molecular Medicine




                     17433.99    0.494459    6158.67    12455.37 0.22829239       899.1    3938.37 0.73516214      1936.27     2633.8    1.145687    19315.8    16859.58   0.4489283    1399.35    3117.09 0.75600314
                     1972.58    1.5571055     763.48     490.32    1.8109257    1686.66     931.38     2.149084     349.57     162.66    0.6658789    802.95    1205.85    1.9094588     415.25     217.47    1.6540347
                     25271.86   1.3422767    19903.48   14828.15   1.2532961   25136.22    20056.09   1.4949228    23617.94   15798.77   1.2972286   21854.46   16847.04   1.7039232    16878.69   9905.78    1.7497518
                     13368.65   0.7663895    2351.26    3067.97 0.96749175       1197.6    1237.84    0.7801026     728.53     933.89    0.6471974   5205.48    8043.11      4.47806     349.02      77.94    1.0305516

                     18218.84   1.6402458    9054.37    5520.13    3.5281167   12367.99    3505.55     2.011843    9385.75    4665.25    0.9999875   20768.56   20768.82   1.4334573     4367.3    3046.69 0.83461565

                                0.88052887    241.08     273.79    1.0226798     866.67     847.45     1.033861     673.24     651.19    2.2302368      77.3      34.66    0.57956266    191.36     330.18    0.8129264
                                                                                                      0.59802556    218.07     364.65    1.1694467    185.79     158.87 0.37496504        93.85     250.29
                     18856.55 0.68511677     12114.83   17682.87   0.8274458   14943.82    18060.18     0.73006    9937.62    13612.06   0.3851127   4135.49    10738.39 0.44937912     2647.27    5890.95    0.5296239
                     29116.09   1.1819056    20726.89   17536.84   2.3335345   46239.13    19815.06   1.1960853    13981.09   11689.04 0.80327755    20781.45   25870.82   1.2247653    16834.57   13745.14   1.0251894
                     31237.2    1.1883966    25388.63   21363.77 0.41542062    10227.76    24620.25     1.40903    11139.41   7905.73 0.79542184     3822.32     4805.4    0.5847561     5773.8    9873.86 0.69067913
                     2239.37 0.81547964      2147.59    2633.53 0.26220137       1545.9    5895.85    0.9688991    2132.76    2201.22    1.5969591   3138.44    1965.26    0.6498711    1313.63    2021.37    0.838603
                     4720.83    1.5310249    1582.59    1033.68    6.3965263    1344.23     210.15    1.8432178    4972.08     2697.5    1.7803158   4279.79    2403.95    1.2780459    1128.31     882.84    1.2915819
                      575.64    0.9455816    260.99     276.01 0.30875352       276.85     896.67    1.0290924     121.33      117.9    0.9051173    332.35     367.19                                      1.3404018




                                                                                                                                                                                                                   UNCORRECTED PROOF
                     31603.98 0.50366175    11256.86   22350.04   0.2909605    3289.64    11306.14   1.4304094     4024.7    2813.67    1.3231302   21276.98   16080.79 0.57265365    2864.86    5002.78    1.3101872
                     4163.92 0.73138124     1622.84    2218.87 0.61594677      1973.82    3204.53 0.95846474      1054.34    1100.03 0.99062526     2153.54    2173.92    1.299583    1028.49      791.4    0.95171505
                     7052.66    1.017466    4381.31     4306.1    1.1718941     6398.6    5460.05    0.7086474    12196.65   17211.17   1.1786094   13301.29   11285.58 0.73000234    4196.01    5747.94    1.0428712
                     7398.12    1.0781957   5175.76    4800.39    1.6052943    8557.84    5331.01     1.054084     2704.4    2565.64    1.046046    1698.58    1623.81    0.9910269   2753.38    2778.31    0.8852622
                     3651.28    0.8051313   3488.94    4333.38 0.27457172      2520.92    9181.28 0.73056847      4654.97    6371.71    0.7808401   5367.12    6873.52    0.8681536   2357.28    2715.28    1.0423795
www.molmed.org




                     21280.57 0.91435397    8924.78    9760.75    0.4860961    12035.9    24760.33   0.8043706    8648.48    10751.86   1.3295033   23210.8    17458.25   0.9475125   12324.74   13007.47   1.0455977
                     1175.76    1.0402197   1180.41    1134.77    0.8148258    2231.93    2739.15     0.981868     930.86     948.05    1.307554    1935.35    1480.13    0.9327272    526.31     564.27     0.858741
                     3325.99    1.8196286   8105.59    4454.53    1.3370435    22571.06   16881.32   0.5628609    2628.69    4670.23    1.199352    3727.37    3107.82    0.5972476    1823.6    3053.34    0.9842091

                     14153.51   0.7033341   6854.18    9745.27    0.2659541    3091.48    11624.11 0.90888447     5514.22    6067.02    1.0122701   20169.32   19924.84   0.5622967   7142.95    12703.17   1.1536263

                     1942.44    0.6947023   2418.87    3481.88 0.09897095       506.18    5114.43    0.9334207     1937.1    2075.27    0.904884     1249.5    1380.84    0.6554359    343.94     524.75    0.9554302
                      475.31    1.2090654   1259.29    1041.54 0.94931066      2545.51    2681.43    1.1027406    1263.84    1146.09    1.4540575   1248.73     858.79    0.6966674    430.84     618.43    0.8475868
                     2238.74    0.5020399   1266.19    2522.09 0.20123222       468.69     2329.1 0.91337585       714.47     782.23    0.7292361   1124.73    1542.34    1.1578747    243.64     210.42    0.7947424

                     63874.96   1.1201196   31836.72   28422.61   1.5988375    16047.9    10037.23   1.4289751    1774.83    1242.03    1.2249687   52715.06   43033.8    1.3809445   7631.14    5526.03    1.0657816

                     6228.52    1.0404599   5216.98    5014.11    2.5978804    12370.38   4761.72     1.220965    3200.54    2621.32    1.1004707   2082.96    1892.79    0.9965157   1421.44    1426.41 0.94219637
                     7286.76    1.4042872   10697.93   7618.05    0.7040685    7794.51    11070.67   1.0112401    5089.45    5032.88    0.9203699   6636.87    7211.09    1.2895281   6683.74    5183.09    1.2767128
                      782.74    1.0565225    438.89     415.41 0.67646307        186.9     276.29    5.2320404     383.09      73.22    1.2861401   1592.55    1238.24    1.1344635    468.42      412.9    0.8612521
                     41353.52 0.61867553    20673.26   33415.35   1.2042876    18360.1    15245.61   0.9799334    4806.24    4904.66 0.73759514     10178.54   13799.63   1.2669948   2598.67    2051.05    1.0295146
                                                                  0.16454068     49.92     303.39 0.21753682         169      776.88    0.7568266    867.24    1145.89    1.3184135    155.23     117.74
                     9630.25    0.7607899   5950.16    7821.03    0.9590585    7871.55    8207.58    0.9639076      2625     2723.29 0.76249933      6639.6    8707.68 0.33120102       729.5    2202.59    1.2283119
                      2099.1    1.0215683    2229.9    2182.82    0.7479582    3308.75    4423.71    1.2296154     3079.4    2504.36 0.75969934     1256.14    1653.47    0.7077496    804.23    1136.32    1.0575218
                      6020.6    0.8832701   5191.04    5877.07    0.6067967     6004.8     9895.9 0.81509864      1690.27     2073.7    0.6943551   1695.74    2442.18    0.0755752     73.15     967.91    0.6243719
                     3466.88    1.2400925   6124.47    4938.72    1.0966028    9263.65    8447.59    0.9953833    5420.34    5445.48    1.1990715   3479.25    2901.62    1.3051273   4987.57    3821.52    0.9683488
                     2171.85    1.8185356   2299.32    1264.38    1.6003618    4052.82    2532.44     1.056164    2150.16    2035.82 0.84642905     1885.81    2227.96 0.68023556     2078.31    3055.28      1.07592
                     4907.11    1.3560221   1295.53     955.39    4.8947735    5608.97    1145.91    2.6647162     350.65     131.59    1.3256726   5939.04    4480.02    1.6441628   1010.19     614.41    1.1882589
Molecular Medicine




                      2183.2    1.3787155    2277.9    1652.19    3.0603237    10633.86   3474.75    1.4381905    2758.78    1918.23    1.5162647   1482.27     977.58    1.3429683   2474.07    1842.24    1.1293668

                     13386.9    1.332282    4688.78    3519.36     2.801049    1644.58     587.13    1.6077069    1482.37     922.04    1.6358291   9774.03    5974.97    1.424615     880.64     618.16    1.4091305
                      329.11    1.213692     235.08     193.69 0.88731617       641.29     722.73    1.3612098     425.31     312.45 0.82439876      678.34     822.83    1.313455     369.58     281.38    0.9773902
                     1279.38 0.73505837     1873.48    2548.75 0.30507654       748.85    2454.63    0.8708866    1748.27    2007.46    0.9627648   1779.95    1848.79    1.2258098   1306.37    1065.72    0.8192461
                      894.47    0.8788431    1460.4    1661.73 0.74781466      7100.41    9494.88 0.97323865       863.36      887.1    0.7954467    554.49     697.08    1.1155694    387.85     347.67 0.80754554
                      418.65 0.72766834      419.69     576.76    0.6837909     570.35      834.1    0.97567505    251.49     257.76    1.3451002   1130.18     840.22 0.59094924      193.92     328.15    1.2216198
                     1845.26 0.67647624      633.52      936.5    0.61590266   1050.73      1706     1.2215511     831.29     680.52 0.76342916      933.17    1222.34    0.6695177    338.16     505.08    1.0523975
                     5792.88    0.4446227   3032.34    6820.03    0.7247977    2101.58    2899.54    0.6804319    4064.73    5973.75    0.9651502   4093.25    4241.05 0.45956966     1597.17    3475.36 0.78870344
                     20256.67 0.90929115    7785.46    8562.12    1.3299729    12826.83   9644.43    0.7282601    4406.44    6050.64    1.3114858   10411.57   7938.76 0.66763264     4764.38    7136.23      1.05107
                     15469.97   0.7229474   4671.18     6461.3    2.0206835    4676.69    2314.41    1.2637687    1890.56    1495.97    1.3401948   17683.83   13194.97   1.1343563   3489.28      3076      1.211749
                      645.83    1.0757378   1161.84    1080.04    1.5564418    1332.75     856.28     1.017495      489.7     481.28    0.9076602    685.71     755.47    1.2982445    627.87     483.63    1.4086924
                      4419.89   1.4256239    3139.01    2201.85    2.5617185     6773.44     2644.1 0.71716005     11022.04   15369.01 0.90061116     10996.67   12210.23 0.93644124    3447.19    3681.16     1.2640287




                                                                                                                                                                                                                      UNCORRECTED PROOF
                       3778.7   1.0034951    4803.43     4786.7    1.7469482    11911.34    6818.37    1.0175378   2603.92    2559.04 0.94942135      2729.33    2874.73 0.97466695     2430.42    2493.59 0.82561916
                      1988.21   1.0449867    1398.14    1337.95 0.74669945       3597.15     4817.4    1.3743623   1428.21    1039.18 0.94214165      1561.76    1657.67    0.8906448    1526.2    1713.59 0.83133507
                      22297.7 0.67126215     3785.16    5638.87 0.33730602       2062.09    6113.41    2.3594952   5235.46    2218.89    0.7748579    20196.09   26064.25 0.68984485    3498.61    5071.59 0.67689925

                     44143.76 0.64147925     10108.02   15757.36 0.24948123      1588.32    6366.49    1.2303642   6749.36    5485.66    1.6498675    43185.02   26174.84    0.89829    3286.78    3658.93 0.96526253
www.molmed.org




                        609.2   1.0019739     664.98     663.67 0.43299899         953.1    2201.16 0.75830835       718.3     947.24 0.97890323       637.08     650.81 0.80450594      361.73     449.63 0.88802415
                      7107.91   1.2457736    8454.28    6786.37    0.6561934    18328.02    27930.82 0.51049715    4838.87    9478.74    0.7081306    7583.59    10709.31   0.5738966   2278.18    3969.67     0.6803717
                     15589.69   0.5822274    1402.58    2408.99    0.4597289     2546.59    5539.33    0.9980649   3429.81    3436.46 0.72905326      5306.99    7279.29    0.5647522   1422.08    2518.06 0.93749964
                     11657.35   0.8493619    8347.97    9828.52    2.3389082    22866.38    9776.52    1.2287331   5374.81    4374.27    0.6618263    5812.51    8782.53    0.6957465   1620.15    2328.65     0.5924444
                                0.2696045      31.63     117.32    1.9404233      909.36     468.64                                      2.6025639      93.38      35.88                                      0.080916405
                      57557.7   1.1450582    28591.52   24969.49   2.3965232     92237.8    38488.17 0.82791877    9316.04    11252.36   1.2284994    40492.19   32960.69 0.62479025    5191.27    8308.82     0.9282203

                                                                   2.9101121     7585.76    2606.69    1.4721626    295.36     200.63    1.6341255     286.74     175.47    1.2329332    236.23      191.6     0.6864929

                      8666.42 0.97778344     2889.79    2955.45    1.1188984     3868.39    3457.32    1.5635977   1728.01    1105.15    2.5219147    6797.67    2695.44    1.0408822   1790.89    1720.55     1.0959474

                                0.80985326    563.01      695.2    0.73929954    1254.34    1696.66     1.30362     1533.8    1176.57    1.4837041     183.46     123.65    1.3921168    771.01     553.84     1.1242344
                      6320.76   1.0906882    6366.62    5837.25    0.5743359     6851.12    11928.77   1.0368419   4403.53    4247.06 0.75788844      4383.24    5783.49    0.6350815   2244.41    3534.05     0.7687642
                       4478.6   0.6311963     1833.6    2904.96    0.4548708     3100.04    6815.21 0.86090666     1183.85    1375.12    2.2992723    6458.61    2808.98 0.36538938      621.14    1699.94     0.8200559
                      6924.66   0.9570565    8195.16    8562.88    1.6880832    11773.84    6974.68    0.8272717   8084.05    9771.94    0.5228306    4005.06    7660.34    1.3771055   4231.79    3072.96      1.076111
                       589.73   0.9315964      681.5     731.54 0.92545485        921.17     995.37 0.47904947      335.44     700.22    0.6155594     712.43    1157.37    0.567587     608.51     1072.1     0.8071139
                       3497.9   0.9608201    2128.86    2215.67    0.6925632     1774.52    2562.25 0.93320286     10743.47   11512.47   0.9713699    8900.08     9162.4    1.1427166   2475.65    2166.46 0.90484846
                     22439.85   1.1430941    9111.18    7970.63     1.370106    12097.57    8829.66    0.7265641    2647.2    3643.45    1.1014758    3238.13    2939.81 0.82139987     2580.37    3141.43     0.7706352
                      9739.75   1.0141854    6677.62    6584.22 0.51844543       6370.04    12286.81   1.0525293   4915.26    4669.95    1.0176066    9523.79    9359.01    1.0439503    6330.4    6063.89     1.0667619
                      8175.61     0.62979    7367.97    11699.09   0.2992081     1490.93    4982.92    0.7569563   12034.47   15898.5    0.5957469    14557.51   24435.73   1.1002072   5074.86    4612.64     0.8344194
                       127.21                                                                                                            0.59040874    320.22     542.37
                     122434.83 0.85407084    21780.02   25501.42   1.7113185     28330.5    16554.78   0.783084    7416.26    9470.58    2.5250807    155332.9   61516.02 0.64396447    6363.74    9882.13     1.1906929
                       4994.9 0.60004497     3310.76    5517.52 0.21340458        1657.3      7766     0.7449778   1214.88    1630.76 0.59600365       6973.6    11700.6    0.9948285   3510.72    3528.97 0.66130817
Molecular Medicine




                      1891.26   0.9333272    1117.93    1197.79    0.2934901      1414.1    4818.22 0.93363357     1216.87    1303.37 0.99833906      2410.32    2414.33    1.2727149     935.7      735.2    0.80466497
                     63874.96   1.1919097    61592.29   51675.3     1.792649    114359.23   63793.43 0.59920913    25833.93   43113.38 0.60877216     39241.17   64459.54   0.7574689   36198.26   47788.45    1.2228235
                      4444.38   1.0666641    1937.03    1815.97     1.440742      7471.4     5185.8    1.5301414   2796.67    1827.72    1.3107505    4790.78    3654.99    1.7533484   2064.48    1177.45     1.0549232
                      7504.06   1.2046367     6485.8    5384.03    1.6964518    13731.42     8094.2    1.1347758   2775.06    2445.47 0.94634455      6691.64    7071.04    1.3055382   2630.62    2014.97 0.96247894
                      7495.69   0.7201735     6493.3     9016.3    1.5575145    12032.47    7725.43    1.0938334   5892.82    5387.31 0.98262656      6903.05     7025.1    1.3738129   7021.31    5110.82     0.9639811
                      7374.74   0.7284802    5677.25    7793.28    0.7441951    13464.09    18092.15 0.86980313    3454.31    3971.37    0.7965613    3450.68    4331.97    0.626072     578.91     924.67     0.8908103
                       161.48    3.434452     153.52       44.7    0.27521574     125.98     457.75    0.599161      25.71      42.91    0.28048465    194.92     694.94    31.742231    275.84       8.69
                     32514.19    0.725135    28531.7    39346.74 0.95925605     15488.13    16145.98 0.95828635    6400.05    6678.64    1.1307995    34668.55   30658.44   1.0948291   6092.68    5564.96 0.95890814
                     36500.17   1.4353999    7466.72    5201.84    11.419623    82220.15     7199.9    1.8811164    884.99     470.46    1.4862666    5140.06    3458.37    2.1991289   1807.86     822.08     1.2721808
                      1482.58   1.1955276    4823.87    4034.93    1.4393508     7832.53    5441.71    1.2846556   3324.56     2587.9    1.0703815    1692.07    1580.81    1.1563469   1788.73    1546.88     1.0698332
                      1154.83   1.1057279    1846.82    1670.23    0.7949742      959.51    1206.97    0.7686888    418.92     544.98     2.099959     867.43     413.07 0.64113903      352.12     549.21 0.59495085
                      681.85    0.9718802    539.17     554.77    4.3949776    966.06     219.81      1.54995     294.01     189.69    1.8140345     349.51     192.67




                                                                                                                                                                                                                    UNCORRECTED PROOF
                     7713.45    0.9348143   3261.81    3489.26    1.638066    7095.84    4331.84     1.929004    4547.82     2357.6 0.79210526      2319.91    2928.79    1.3199688     2170.9    1644.66    2.1774158
                     1501.31    1.0087901    501.52     497.15    0.9256237    885.97     957.16    0.9550734     397.96     416.68    1.3564228    1115.59     822.45 0.112145275       32.05     285.79 0.90712917
                     1053.05    0.7258172    697.67     961.22    1.0961403   1721.28    1570.31    1.2669581     498.51     393.47    0.7365876     735.63      998.7    0.33909437    151.27      446.1    0.84378284
                      626.43    0.9925911   2545.47    2564.47    1.1412234   9292.56    8142.63     1.042277    2346.52    2251.34    0.7150318    1339.04     1872.7 0.93638724       969.32    1035.17    0.9029737
                      362.87     1.18932     157.24     132.21    0.7326577    246.51     336.46    1.2074438     423.68     350.89    1.1116692     701.63     631.15    0.6550244     279.25     426.32    0.5362733
www.molmed.org




                     18103.08 0.89651847    19728.92   22006.15    0.71554    29621.46   41397.35   1.0140809    16739.91   16507.47   1.0270617    11710.24   11401.69   1.3470165    19380.98   14388.08   1.0575595
                     12454.48 0.99412054    7458.22    7502.33 0.81905067     10390.78   12686.37   0.7523756    4673.08     6211.1    0.74081147   6453.09    8710.84 0.75114965      4908.32    6534.41    0.7273331
                     2297.87    1.3205718   3287.22    2489.24    1.0042834   10222.49   10178.89   0.9676636    2824.31    2918.69 0.84304553      2342.95    2779.15    0.9721715    1336.94    1375.21     1.003849
                     4730.38 0.89772683     10725.86   11947.8    1.0010235   14219.99   14205.45   0.9196479    6795.03    7388.73    0.8096152    3960.16    4891.41    1.1979073    6845.07    5714.19    0.9279428
                     1545.86    1.0327803   2532.14    2451.77    0.8546312   3060.34    3580.89    0.9546216    3322.78    3480.73 0.55745584       182.21     326.86    1.3063866    7640.69    5848.72    0.9105455
                     4407.35 0.65655667     1906.24    2903.39    0.6016063   1458.36    2424.11    0.6880489    1067.15    1550.98 0.53717923      2038.81     3795.4 0.94099987      1325.85    1408.98    1.3058068
                     3462.87    0.7065511   2802.98    3967.13    0.4539165   2134.12    4701.57    1.1527069     1358.2    1178.27    1.4330014    2722.76    1900.04    1.5170045    1137.01     749.51    1.0065243
                      733.12                                                                        1.7438132    1968.05    1128.59    1.0817251    1102.57    1019.27     2.675722     485.59     181.48    1.3270547
                     4497.97    0.8089443   2551.03    3153.53    1.9270458   8976.97    4658.41 0.91298044      4078.53    4467.27    1.0249187     3688.6    3598.92     0.915208    5308.92    5800.78      1.04131
                      285.26    1.3378974    118.23      88.37    0.7290573    494.68     678.52     4.737871      65.43      13.81     1.299671     438.47     337.37      1.46882     105.05      71.52    1.2007575
                      792.76    0.9837113   1087.06    1105.06 0.49673718      4667.7    9396.72    0.7446072     430.45     578.09    0.7625332      607.8     797.08                                       0.8551274
                     4526.01    0.9384206    931.42     992.54    1.4826916   1338.07     902.46    0.8930868    17074.23   19118.22   1.0335095    2814.05    2722.81       0.8194     763.14     931.34    1.3290496
                     8128.56    0.8710404   6482.64    7442.41    1.0234864   6672.64    6519.52    0.9803591     3193.5    3257.48 0.96863437      3267.32    3373.12 0.58553123       949.72    1621.98    0.9050131
                      501.29 0.89934516      574.07     638.32 0.69804335      874.39    1252.63    0.7329498     379.69     518.03    0.9985509     882.05     883.33    1.0058864     500.68     497.75    0.7933984
                      212.27    1.4485323    580.34     400.64    0.9819066   4939.54    5030.56 0.40385854       238.85     591.42 0.66897976       648.79     969.82    0.8865104     347.45     391.93    1.0979881

                                1.0109029    721.35     713.57    0.7208638   2374.23    3293.59    0.9842166     374.77     380.78 0.95910186       131.56     137.17    0.3041978     312.04    1025.78 0.97179776

                      123.62    1.4796122   1263.87     854.19    3.4723089   5334.89    1536.41    1.2944891     776.81     600.09    2.3737009     529.81      223.2    1.9481363     668.99      343.4    1.1899116

                      815.87    1.3726842   1231.49     897.14 0.79232985     3506.44    4425.48    0.7468094    1318.97    1766.14    0.7139125    1481.04    2074.54    0.7829029     852.73    1089.19    0.8483718
                     14012.96 0.66107583    6958.55    10526.1    0.6041335   5871.38    9718.68     0.648121    5191.54    8010.14    1.1965725    13128.89   10972.08 0.61905646     5815.46    9394.07    0.9136866
                     1400.36    0.5142959    1098.5    2135.93 0.50253755      642.64    1278.79 0.85184973       2744.6    3221.93    1.0171671    1273.31    1251.82 0.62932956       849.06    1349.15 0.73314714
Molecular Medicine




                     1286.96    0.5991532    656.63    1095.93 0.75561726     2247.78    2974.76    0.6873015    5773.03    8399.56    0.8560583    7711.39    9008.02 0.70642745       4432.5    6274.53 0.79239666
                     3216.85 0.99384093     2578.56    2594.54    2.3848505   4694.65    1968.53    0.7424438     725.13     976.68    1.2191701     3677.7    3016.56    1.2404119    1033.66     833.32 0.97955143
                      160.66    0.9925505    162.55     163.77    1.7161498    426.12      248.3    0.86208457    265.91     308.45    1.2255626     358.33     292.38    0.5023973      62.87     125.14    0.6020749
                     8260.44 0.90422755     10645.94   11773.52   1.2066474   10996.77   9113.49    1.4637778    20156.44   13770.15   1.0654489    12243.36   11491.27   0.9409021    6888.26    7320.91     0.743771
                      954.12 0.64873147     1022.79     1576.6    0.6533904    1500.4    2296.33    1.1645062    1223.57    1050.72    1.3054285    1184.35     907.25 0.99874216       714.63     715.53 0.78104764
                     3318.73    1.4201844   3869.86     2724.9    2.0383537   5194.54     2548.4 0.95443356      4831.82     5062.5     1.188736    4091.51     3441.9    1.2251204    2412.85    1969.48    1.2564998
                     2626.47 0.76522297     2546.57    3327.88 0.58715975     2331.77    3971.27    0.8749303     988.75    1130.09 0.85053694      1311.46    1541.92    0.9221181     301.09     326.52    0.8828273
                     3995.88    1.6903242   5302.26    3136.83    5.0615964   7472.84    1476.38     2.351654    1594.68     678.11     5.860531    9669.35    1649.91    2.0370631     976.67     479.45 0.85494435
                     3648.67    0.9535665   4674.86     4902.5 0.58564776     2361.73    4032.68     1.271807     2937.2    2309.47    0.8851887    2470.19    2790.58    1.3346795    3694.78    2768.29 0.80851555
                     36929.09   1.5715601   20036.92   12749.7 0.10262604     6251.31    60913.48   0.7938853    10739.22   13527.42    3.196007    74303.42   23248.83 0.22144416     4296.71    19403.13 0.59948945
                     4371.49    1.0019953   1702.32    1698.93    2.0325236   12674.98   6236.08    1.8315938     805.48     439.77    1.0826794    3166.48    2924.67 0.83838445       653.68     779.69    1.5751706
                     35955.29   0.6434928   29774.42   46270.01 0.26185942    9933.37    37933.98   0.9872817    18584.6    18824.01   1.3711966    37542.97   27379.71   1.2088577    22051.11   18241.28   0.9975931
                     21953.73   1.0556829    3925.24     3718.2    0.7359535   13372.23    18169.94   1.0541508     7136.38    6769.79    1.0957829    10903.16    9950.11    1.1124355   3283.62    2951.74    1.1004709




                                                                                                                                                                                                                       UNCORRECTED PROOF
                     1140.61    1.0266681    1610.37    1568.54    1.4435406    4766.21    3301.75    1.0462956     1364.38    1304.01 0.79862463       1085.85    1359.65    1.2229196    261.13     213.53    0.9058947
                      684.14    1.2599306     228.69     181.51    1.4422573      963.5     668.05    1.6427432      597.17     363.52    1.3285552      726.64     546.94    1.9672424     774.7      393.8    1.2570302
                     1623.73    1.1632651    1269.89    1091.66    1.0910709    3058.49     2803.2    1.0807549     1077.21     996.72 0.78403294        1981.8     2527.7    1.0269749   1165.75    1135.13 0.91064435
                     24705.08   0.9455652    24182.31   25574.45   0.7926422   39425.98    49739.95   1.1089981    19877.17    17923.54 0.87987024     17863.39    20302.3    0.7849376   4537.12    5780.23     1.085053
                     4696.84 0.56489116      2491.43    4410.46    0.4912705    2658.26    5410.99    1.2448269     4558.22    3661.73    0.6472619     2009.58    3104.74    1.0134492   1046.67    1032.78    1.1007653
www.molmed.org



                      319.01     1.288116     368.53      286.1    1.2289286      457.1     371.95 0.71620136        709.29     990.35      1.32618        749      564.78    0.6349433    230.84     363.56     0.848652
                                0.62826604    524.91     835.49 0.72752666      1315.07    1807.59    0.6916472      191.69     277.15 0.32585672        117.24     359.79    14.705053    145.58        9.9    0.7592085
                      400.51    2.2755804    5470.29    2403.91 0.99087274     22981.47    23193.16 0.36316302      1638.49    4511.72    0.7647828     4924.62    6439.24 0.48662615       973.7    2000.92    0.9267027
                     26504.44   1.6453278    9597.74    5833.33    6.553151    19132.97    2919.66    4.6222987     4246.09     918.61     5.537415    21805.51    3937.85 0.80648583     2291.92    2841.86 0.85281897
                     1119.31    0.75405705    969.28    1285.42 0.48228619      1027.53    2130.54    0.9967584      762.57     765.05    0.9708315     1242.14    1279.46    1.5311042    810.49     529.35     1.208932
                     63874.96   0.9914452    41532.44   41890.81 0.63917214    11683.85    18279.66 0.89131504      3179.08    3566.73    1.4351872    88986.81    62003.63   1.2490212   10680.03   8550.72    1.2018936
                     24038.36 0.92936873      9347.2    10057.58 0.61557996    10633.75    17274.36 0.84648734      6638.23    7842.09       1.0192    11769.15    11547.44   0.9896915   4543.09    4590.41    1.0384297
                     12215.14   0.9492506    5648.24    5950.21    1.7681525   10046.59    5681.97    1.1375978     4934.08    4337.28    2.3836558    11676.91    4898.74    1.0788002    2543.8    2357.99 0.95542043
                     2752.86     2.073288     1273.6     614.29    4.3561716    5413.24    1242.66     2.552346      505.39     198.01 0.84078586        327.36     389.35    2.5625677     590.8     230.55    25.123657
                     11284.66   1.3458848    6732.21    5002.07    2.6308458    7619.35    2896.16      1.10881    30871.83    27842.31   0.9326659    19762.92    21189.71   1.1603446   5262.29    4535.11    1.2452635
                     2009.81    0.7551951    2552.31    3379.67 0.28069228      1011.34    3603.02 0.96917623       1213.05    1251.63    1.4973676     2036.45    1360.02    1.2768219   1337.79    1047.75    1.0684577
                     3244.27 0.86928135      3958.82    4554.13 0.43036535       3053.3    7094.67    0.7484505      2997.2    4004.54 0.98585784       2953.65    2996.02 0.97474885     1968.71    2019.71    0.6732495
                     5632.81 0.85881007      5162.17    6010.84 0.49720296      3756.05    7554.36 0.86139965       2877.85     3340.9    1.1549337     4734.72    4099.56    1.056376    2021.65    1913.76    1.0146984

                     6174.04    0.9709715    9873.11    10168.28   1.8111943   43978.42    24281.45 0.84988683      9407.78    11069.45   0.8822454     3490.71    3956.62 0.96645445     6949.31    7190.52    0.9577034

                      377.59    1.9762682     212.35     107.45    0.6657721    1056.82    1587.36    0.8948991      551.75     616.55 0.79917425        704.56     881.61    1.6445887    344.64     209.56 0.68810433

                      609.56                                       1.0469102      106.9     102.11    0.46373248     162.26      349.9    0.88403594     839.18     949.26 0.26931074       68.65     254.91 0.04878584

                     1467.32    0.9101673    2213.19    2431.63 0.48980707      2868.07    5855.51    0.6746773     1024.43     1518.4 0.52832544       2161.95    4092.08    1.5655001    803.54     513.28 0.95230633

                                0.04721536       4.4      93.19    1.1035584     418.05     378.82     0.705676       189.1     267.97                                                                          0.6758415

                     67236.51 0.68061084     27335.83   40163.67 0.19239047     9295.42    48315.39 0.65936214     16367.05    24822.55   1.3226584    74189.07    56090.88   0.9689825   18898.6    19503.55   0.9555794
Molecular Medicine




                     21325.32 0.84129035     4671.98    5553.35    1.7995049   15923.98    8849.09 0.92212003       3883.14     4211.1    0.92668676   14148.19    15267.5    1.0033807   8390.35    8362.08    1.0267432
                       65.01    1.6172938     682.87     422.23 0.25109592      1266.45    5043.69     1.419371      481.11     338.96     5.310623      328.94      61.94    1.2599072    271.51      215.5    1.4174131
                      598.91    0.5850578     184.34     315.08    1.7380017     880.35     506.53    3.7836556      246.77      65.22    1.6108159       570.1     353.92    1.7291228    262.55     151.84 0.14829536
                     1140.02    1.1600248      859.3     740.76    1.327488     1265.68     953.44    1.0885785      745.23     684.59    1.1827463      612.84     518.15 0.92410827      825.09     892.85 0.99363405
                     3579.87 0.96193403      3051.12    3171.86 0.52759075      2697.83    5113.49    0.7161746     1939.63    2708.32 0.58937985       2073.68    3518.41 0.40864086     1268.36    3103.85    0.5267428
                      214.78    0.8765867     176.79     201.68    2.2780886     827.06     363.05                                        0.33329037     155.14     465.48                                      0.91001767
                     63874.96   1.4845108    95358.42   64235.59   6.203446    398994.97   64318.28   1.5990901    103357.19     64635    2.0640981    133050.81   64459.54   1.0137271   44673.74   44068.8    1.3648741
                      4222.2    1.8886535    2237.62    1184.77    1.0890871    1706.36    1566.78     1.632531     1015.32     621.93     2.032633     6408.79    3152.95    1.2731073   1708.37    1341.89 0.95742446
                                1.2449588     162.99     130.92    0.8730477     988.29      1132     1.0371559      507.75     489.56    1.6395365      458.48     279.64    1.6979926    228.38      134.5    1.5891868
                     1053.22    0.6232789    1097.27    1760.48 0.53745914       956.86    1780.34 0.89894295       1350.41    1502.22    0.8854447     1236.86    1396.88 0.64537835      760.43    1178.27 0.97781426

                     8621.29 0.93583685      3591.77    3838.03    1.3122181    7850.62    5982.71    1.0546155     2132.58    2022.14     0.562068     3708.03    6597.12    1.3570806   2407.61    1774.11     1.231599

                                0.68421054     88.79     129.77                                       0.99467045     153.04     153.86 0.18684198        117.66     629.73    0.9997133    209.26     209.32    1.2878162
                     7369.08    1.0814317   4271.85    3950.18    4.4365463   24517.64    5526.29    1.2518921   5326.15    4254.48    2.4159048    10267.74   4250.06    1.8224635   4515.39    2477.63    1.4077095




                                                                                                                                                                                                                  UNCORRECTED PROOF
                      4273.5    0.7561096   3106.93     4109.1    2.0597746    6288.08     3052.8    0.8004349   2164.52    2704.18    1.1964866    6030.46    5040.14 0.69025517     2975.98    4311.42    1.0598707

                      490.77 0.53540015      408.43     762.85 0.19123843       257.82    1348.16    0.6178946    469.81     760.34    1.0565239     815.89     772.24 0.57183427      285.94     500.04 0.97987264

                     69927.73   1.049638    25893.72   24669.19   2.6272914   53663.11    20425.26   0.5497509   15191.18   27632.84   0.7807452    22590.41   28934.42   1.1340574   8460.25    7460.16 0.93750054
www.molmed.org



                     8305.37 0.81720525     4751.46    5814.28    1.173115    15168.33    12929.96 0.78347677     7600.9     9701.5    0.9511813    9107.59    9575.03    1.0173528   2394.93    2354.08    1.4095674

                     9912.97    1.0099511   3976.42    3937.24    1.0695391    3613.32    3378.39    0.764559    10689.75   13981.59 0.83110285     10150.5    12213.29   1.345507    3478.62    2585.36 0.97881097

                     1756.31 0.73836905     1406.15     1904.4    0.3010433     1234.1    4099.41    1.000339     914.58     914.27 0.78718704      2018.93    2564.74    1.6089995   1040.91     646.93 0.91470987

                      560.35    1.3156335   1052.52     800.01 0.62748194       1316.2    2097.59    1.046997     535.34     511.31    0.49429694    339.32     686.47    1.304064     531.38     407.48    1.014166

                     3003.32 0.75271595     2271.17     3017.3    1.6971813     9391.2    5533.41    0.7999472   2998.53    3748.41    0.7291307     2596.5    3561.09    0.9566912   1252.06    1308.74    0.9975415
                     63874.96   1.243859    61665.36   49575.84   1.8546505   119287.93   64318.28   1.4568863   63899.73   43860.48   1.3792285    63868.86   46307.67   0.7610683   30427.64   39980.17   0.7973708
                     56861.84   1.0523294   43558.53   41392.49   1.6950198   79234.79    46745.64   0.7805714   43998.9    56367.55   1.1772602    44539.67   37833.33   0.8277197   27905.61   33713.84   1.0182198
                                0.7482471    157.94     211.08                                       0.3245457     12.68      39.07    1.9862069      60.48      30.45
                      840.73    1.4665757    655.31     446.83    1.6303009    1222.53     749.88    2.3873258   1177.62     493.28     3.419842    1333.67     389.98     0.68491     344.77     503.38    1.4669347

                     1971.63    1.3523381    1737.2    1284.59    1.1273311    2956.11    2622.22    0.789883    1138.34    1441.15    1.4466535    3232.88    2234.73    0.9345848    923.51     988.15    0.7916153

                     7637.03    1.8762832   4766.81    2540.56    2.3260381   20115.02    8647.76    0.7933411   2936.56    3701.51 0.52294385      2893.14    5532.41    0.9272709   2551.97    2752.13 0.98976445
                     1010.21 0.55700934      571.72    1026.41    1.019084     1566.22    1536.89    1.0513566    871.48     828.91    0.8759886    1352.36    1543.81 0.57089067      319.91     560.37    1.4354233
                     1856.71    1.0438868     795.4     761.96 0.31636038       476.85     1507.3    0.9315205   3419.64    3671.03    0.8937919    4725.46    5286.98    2.2323918    927.09     415.29    1.0393677

                     2583.72 0.80073416     2973.27    3713.18    0.7962836    8774.87    11019.78   1.1610694   1806.74     1556.1    0.9031699    1687.04    1867.91    1.1997077    336.71     280.66    1.1024543

                     16931.14   0.5074588   7339.57    14463.38   0.2378393    3109.43    13073.66   1.0397128   9005.95    8661.96    0.7359724    20692.52   28115.89   1.0204573   9274.69    9088.76    1.0600148
                      724.75    14.564402    402.56      27.64    0.5168102     152.49     295.06 0.31479204       69.27     220.05 0.35278156      1413.25    4006.02
                     3873.47    1.1281893   4841.94    4291.78    1.2653203    6340.09    5010.66    1.1519581   1085.11     941.97 0.84833825      1162.97    1370.88    1.1923888   1375.17    1153.29    0.7896352
                     1123.52    0.9920685    1268.3    1278.44    1.6521521    2473.47    1497.12    1.0799555   1194.96    1106.49 0.82796675      1241.47    1499.42 0.71954805      815.91    1133.92    0.8543201
Molecular Medicine




                     3742.99    0.7510668   1918.51    2554.38 0.33536813      6191.01    18460.34   1.2237295   1876.43    1533.37    1.1670084    1963.34    1682.37    0.8951189    445.08     497.23    1.2169913
                     19076.35 0.95023614    16673.47   17546.66 0.82451195     8627.05    10463.22   1.1863017   11492.31   9687.51    1.1782236    11211.94   9515.97    0.9056143   11238.43   12409.73   1.1386714
                     3450.33    0.8953929    1249.1    1395.03 0.79451495      1458.65     1835.9 0.76656574      460.66     600.94    1.0356486     3029.5    2925.22 0.72175664      540.87     749.38 0.62920076
                                1.2026001    616.97     513.03    0.7634749    6160.54    8069.08    0.6450825    198.15     307.17 0.80891657       245.49     303.48    0.8041798    199.71     248.34    1.1921986
                     1052.99 0.88170534     2075.94    2354.46    2.7895076    2495.94     894.76 0.97075963      1163.3    1198.34 0.80014086       602.25     752.68    1.5322771   1585.11    1034.48 0.99417377
                     5046.86    0.9493765   1278.44    1346.61 0.23926015       330.77    1382.47    1.1149297   1542.26    1383.28 0.94530964      2817.07    2980.05    0.9584539   1305.28    1361.86 0.86615497
                     7952.37    1.2147608    4913.1     4044.5 0.43435866      1034.79    2382.34    1.7518488    3669.3    2094.53     2.933421    7119.94    2427.18    1.737583     1645.3     946.89    1.4737467
                                0.7496768    289.96     386.78                                       0.6790284    240.96     354.86      1.53317     556.28     362.83    0.3710004     423.1    1140.43    1.2942752
                      405.67 0.72760534     1517.21    2085.21 0.26350147       648.68    2461.77    1.0725089   1551.47    1446.58    0.7336379     907.18    1236.55    1.180705       538      455.66    0.8595277
                     4741.35    1.1309088   4165.42    3683.25    1.8134338   14332.22    7903.36    1.2794776   3441.59    2689.84    1.3062798    6996.67    5356.18    1.2130716   3230.07    2662.72    1.0486367
                     1676.61 0.94183123     3042.84    3230.77    0.9298296    8003.22    8607.19    1.0405358   1065.03    1023.54    0.5444766     621.03     1140.6    1.1226645    1190.9    1060.78 0.86709565
                      4713.5    1.3803056    720.63     522.08    1.1303239     740.43     655.06    1.115557      741.6     664.78    0.9413789     2925.9     3108.1    1.3553292    275.43     203.22    0.9795317
                     5660.26    1.2533542   5780.57    4612.08    3.2197263   20552.48     6383.3 0.89692324     2992.71    3336.64 0.88875645      6691.59    7529.16    0.9221136   2877.52    3120.57 0.94545114
                     3000.28    0.7776457    3236.6    4162.05    0.746368     3488.89    4674.49    0.9169203   1195.71    1304.05     0.7283235    2873.36    3945.17    0.6550183    1339.84     2045.5    0.8986525




                                                                                                                                                                                                                    UNCORRECTED PROOF
                     2565.13    0.635509    1543.27     2428.4 0.20434996       627.62     3071.3    1.396894    2455.53    1757.85     1.4470961    3618.29    2500.38    0.5433088     307.98     566.86    1.0606805
                     3418.71    1.0272347   1486.08    1446.68    0.4434889     822.53    1854.68    1.2476445    740.24     593.31     1.6770917    3870.61    2307.93     1.371831     590.34     430.33    1.1050729
                      3016.8    0.9428461   1143.38    1212.69    0.6703609    1014.96    1514.05    1.302398    2405.49    1846.97     1.0854913    1563.14    1440.03    1.1368036    1248.54    1098.29    0.8629914
                     63874.96   1.1474698   35414.05   30862.73   1.8396156    59789.9    32501.3    0.9261686   41186.8    44470.09    0.7335544    40019.62   54555.76   1.2230444    20594.88   16839.03   0.8128906
                     8136.72    0.7691181   5807.88    7551.35    1.2437721    8733.01    7021.39 0.41643825      720.23     1729.5 0.56293404       6950.18    12346.35   0.6384179     484.54     758.97    0.7908036
www.molmed.org




                     25874.25   1.1143444   30261.18   27156.04   3.0868297   34746.22    11256.28   1.1556511   14043.98   12152.44    1.2545794    17746.29   14145.21   1.1404117      7600     6664.26    1.1314857
                     4547.32    1.2401009   4508.56    3635.64 0.35374403      2102.98    5944.92    0.6711299   3351.73    4994.16     0.9398092    3847.09    4093.48    0.6935131     974.06    1404.53    0.641016
                     3248.28 0.68353766     1812.12    2651.09    1.436569     3575.06    2488.61    1.1117598    944.64     849.68     1.2933097    1904.89    1472.88    1.0494093     351.72     335.16    1.5380455
                     4732.09    0.8540997   2192.38    2566.89 0.26504973       985.37    3717.68    1.7015501    740.94     435.45     1.2745697    5353.55    4200.28    1.4736155    1084.36     735.85    1.0829617
                     17207.25   1.8127347   13874.49    7653.9    4.2593164   30082.36    7062.72    1.1395292     2438     2139.48     1.4994365    13713.86   9146.01    1.2986915    3610.57    2780.16    1.2122669
                     17828.94   1.2551577   7560.43    6023.49    1.0766265    2946.07    2736.39    1.4157652   18349.93   12961.14    1.2199235    20007.89   16400.94   1.4409657    4435.35    3078.04 0.90708935
                       5492     1.2705321   4413.46    3473.71    2.7875938   12573.86    4510.65    1.4976654   3467.41    2315.21     1.1482168    5580.46    4860.11    1.3895633    4718.86    3395.93    1.0699025
                     1700.35    1.3366436    760.47     568.94    2.690964      3867.4    1437.18    1.502456    1098.16     730.91      1.120915     963.83     859.86     0.757434     856.87    1131.28    1.0758297
                     10683.54   1.2276434     5995     4883.34    1.5868725    7988.84    5034.33    1.4802079   3828.75    2586.63     1.8484819    6034.72    3264.69     2.051977    3416.48    1664.97    1.3028929
                      962.47    2.3052506    291.96     126.65    11.178679    1360.11     121.67                                      0.085394405     75.51     884.25 0.34979168        39.46     112.81
                     4107.17    1.4446725    985.57     682.21     2.85771     3232.47    1131.14    1.2979263    660.32     508.75     0.8479729     2256.6    2661.17    1.2579505    1014.99     806.86    1.464436
                     11374.16   1.4490669   12944.37    8932.9    1.7755198   31108.69    17520.89   1.147372    12251.11   10677.54    0.8750065    9026.61    10316.05   1.3231561    8659.21    6544.36    1.0857872

                      304.75    1.6063732     1845     1148.55    0.8162723    1545.53     1893.4    0.8029007    726.32     904.62     1.1238037      818.5     728.33    1.5494301    1393.48     899.35 0.38092637

                     2724.13    1.0366513   3977.04    3836.43    0.8590815   12102.62    14087.86   1.0768616   3385.19    3143.57     1.0240488    3088.48    3015.95    1.8316065    1477.85     806.86    1.0507286

                     6730.77    1.3363758   3948.71    2954.79    1.7157576   33533.49    19544.42   1.2239523   2020.17    1650.53 0.61735827       2950.46    4779.17    1.5191334    2612.15     1719.5     1.00172
                     4846.51    0.7951876   3657.68    4599.77    0.5446248     2777.2    5099.29    0.5295324   1748.41     3301.8     0.7418428    2681.25    3614.31 0.67704636       768.17    1134.59 0.46575728
                      6380.2    0.5641906   5679.16    10066.03 0.30957526     4921.77    15898.46 0.93838054    4156.05    4428.96     0.6471477    5108.28    7893.53 0.82879984      1353.77    1633.41    0.823035

                     9404.32    0.9553049   5286.82    5534.17    0.7939913   16563.89    20861.55   1.2043469   9967.74    8276.47      1.105888    14750.5    13338.15 0.96768117     3999.01    4132.57    1.0440875

                      163.73    1.0256084    217.07     211.65    3.9594214     241.01      60.87    0.8955393    173.86     194.14       5.49078     300.73      54.77    1.7885498     401.44     224.45
Molecular Medicine




                      414.19                                      0.5489659     270.47     492.69                                      0.43612096     261.69     600.04    12.898552       53.4       4.14    2.6715708

                     41613.44   1.3642712   62360.37   45709.66   3.2533228   187295.55   57570.54 0.35679215    8365.26    23445.75    1.2073168    35506.97   29409.82   1.0503455    16789.68   15984.91   0.8058159
                     9751.74    0.6429997   2397.54    3728.68    0.8029896    2409.25    3000.35    1.1565928   5420.06    4686.23     1.0158373    14945.73   14712.72   0.6338399    2454.45    3872.35 0.89375085

                     32151.89 0.89924455    15942.05   17728.27   0.7461271   21883.99    29330.11   1.0047407   1835.41    1826.75     1.1480662    23412.09   20392.63   1.2422829    2859.76    2302.02    1.3846296

                     63874.96   1.0917156   10997.31   10073.42   1.2661691    7313.24    5775.88    1.6389779   12785.06   7800.63     1.7224667    40163.53   23317.45   2.0708456    11094.97    5357.7    1.0673854
                     5445.81    1.8223805   2808.58    1541.16    5.506606    10561.45    1917.96    5.5205607   4169.79     755.32     3.3524435    3381.61     1008.7     3.498706    5678.47    1623.02    2.054738
                     26374.19   1.7798886   32759.67   18405.46   4.663849    181821.88   38985.37   1.4975501   30582.34   20421.58    2.0967433    14667.16   6995.21    2.5059104    13531.49   5399.83    1.2792919
                     16714.74   1.1577413   2727.21    2355.63    2.1734695    9051.37    4164.48    1.5199387   2299.12    1512.64 0.85256046       6886.02    8076.87    1.4406027      1507     1046.09    1.2563608
                      448.97 0.79161483     1164.41    1470.93    0.1779585     684.27    3845.11    0.8262867    1176.5    1423.84 0.66656315        923.19      1385     0.80269665   1199.59    1494.45    0.7919857

                      395.77    2.037727       87.5      42.94                                       1.3394222     85.79      64.05     1.6936436     590.98     348.94
                     23896.64 0.91777724     17017.62   18542.21   2.0600433   59469.68    28868.17    0.68215    16430.92   24086.96   0.7588296   25394.02    33464.72   0.8025831    6925.2    8628.64 0.91363883




                                                                                                                                                                                                                    UNCORRECTED PROOF
                     7522.91     1.462681    5326.28    3641.45    1.1940094    9496.22    7953.22    1.1733118    7020.3    5983.32    0.8049768    4836.84    6008.67 0.90667963      2553.5    2816.32     0.928396

                     4544.53    1.1394994     530.87     465.88 0.58846706       809.56    1375.71    0.9386762    771.62     822.03    0.8219009     2459.3    2992.21    0.9169866    630.63     687.72    1.3551377

                     12155.46 0.92968655      4965.4    5340.94 0.18874834      1142.86    6054.94    1.247589      26707    21406.89   1.0071404    23749.7    23581.32   1.1475359   4092.09    3565.98 0.86910886

                     1621.02    0.7333946     318.99     434.95    1.1662155    1150.46     986.49    2.0250878    276.06     136.32    1.2115895     894.25     738.08    1.5530074    256.65     165.26
www.molmed.org




                                0.91895103    317.13      345.1    0.8571337    1874.62    2187.08    1.1414783    464.81      407.2     5.45535      209.54      38.41    1.1107405    143.23     128.95    1.0009454
                     12463.16   0.6220873    7273.22    11691.64 0.44785053     3782.72    8446.39    0.8053771   5260.53    6531.76    0.7370658    9103.19    12350.58   1.029761    12120.06   11769.78   0.8412174
                     2825.46    1.4736341    3717.36    2522.58    3.752759    20339.39    5419.85 0.39365393     1345.58    3418.18    0.6646155    1278.84    1924.18 0.53297794      834.91     1566.5    1.6478457

                     27946.33 0.98411125     7335.89    7454.33    0.4866415    6402.08    13155.64   1.0349535   8128.97    7854.43    1.2015096     12912     10746.48   0.6245886   3118.24    4992.47    1.2221636
                      495.08     1.088642     208.66     191.67    0.6095829     122.77      201.4    1.0768402    189.89     176.34    2.1380913     597.96     279.67    0.6416528    181.53     282.91    1.1167278
                     5013.46 0.71914893       4007.4    5572.42 0.61845165      7343.81    11874.51 0.81048745    4230.08    5219.18    0.8427058     3313.3    3931.74 0.71230686      659.24      925.5    1.0635624
                     7908.57    0.6564167    5850.78    8913.21    0.4379371    3445.65    7867.91    0.9064266    3442.4    3797.77 0.71312046      3365.13    4718.88    0.7025665   1209.96     1722.2    0.9150338
                     1115.97    2.1385272    1572.01     735.09 0.12475398      1015.46     8139.7 0.31106016      511.61    1644.73 0.40260848      1400.82    3479.36                                      0.24460083
                      2621.9    1.2891275    1359.14    1054.31    0.5522985     834.65    1511.23 0.67435056     2584.59    3832.71    1.038266     3421.18    3295.09    1.0538161    651.29     618.03    1.1718197
                      4229.2    0.7347284    6005.89     8174.3 0.09533439       560.06    5874.69     0.57371    3426.07    5971.78    0.5286737    2223.85    4206.47    0.7867201   2741.94    3485.28 0.79995644
                      1825.4     1.114568    2264.49    2031.72    1.0052627    4790.66    4765.58    1.2077748   2173.27     1799.4    0.884305     2296.54      2597     1.1935376   2181.56    1827.81    0.9146494
                      7277.7    0.7169141    5024.55    7008.58    0.4655323    5551.04    11924.07   0.9848726   5197.98    5277.82    1.4133554    5506.39    3895.97    1.2619553   2802.79    2220.99    1.2840922
                      963.56    1.5663635     866.34     553.09    1.0469325     1657.2    1582.91    0.7843308    577.44     736.22    1.5652046     690.49     441.15    0.3366504     59.88     177.87    0.4972393
                     4538.73    1.0975727    2478.89    2258.52    2.243152     5886.21    2624.08    1.430505    1929.88    1349.09    1.0534027    3047.81     2893.3    0.9604554      1424    1482.63    0.8752697
                      824.46     3.782859     433.44     114.58    5.8220525    1470.01     252.49    2.5137177    395.81     157.46    1.7380669    1021.01     587.44    1.4843237    469.64      316.4    1.3950331
                     20392.1    1.5432832    5421.43    3512.92    4.3133645   66030.45    15308.34   1.442091    13162.6    9127.44    2.1895766   16353.86    7468.96    2.2532432   21445.94   9517.81    2.1957242
                     36695.34   2.0597277    8457.14    4105.95    12.802264   48442.74    3783.92    2.9399369   40997.98   13945.19   5.0280256   21056.82    4187.89    4.5278163   13299.69   2937.33    2.7922013
                     30662.74   1.3805062    11748.3    8510.14    2.5516493   50511.38    19795.58   1.4188555   14749.94   10395.66   1.0340531   24223.85    23426.12     1.4244    24783.45   17399.22   1.3683767
                     16056.27   2.7120025    10685.1    3939.93    13.423566   67803.09    5051.05    4.5023217   14476.9    3215.43    5.502194    11348.22    2062.49    2.7769575   4573.51    1646.95    2.0522795
                     63874.96   1.8683183    70616.17   37796.65   5.0465245   206839.02   40986.43   1.8172867   33504.46   18436.53   1.0820748   69702.99    64416.06   1.684436    47205.24   28024.36   1.4359617
Molecular Medicine




                     29518.88   1.5542717    21320.97   13717.66   5.079437    68497.27    13485.21   1.3672515   15157.05   11085.78   1.7082561   19884.34    11640.14   2.056862    17573.85   8544.01    1.2450646
                     4295.98    1.6262323     377.79     232.31    2.0408585    4558.36    2233.55    1.2209027    943.77     773.01    1.392235     2488.62     1787.5    1.4691377   1384.53     942.41    1.0409971
                     11217.88   1.7067801    13105.05   7678.23    2.285663    31310.22    13698.53   1.1225461   26897.53   23961.18 0.82915163    13774.97    16613.33   1.0527534   13155.86   12496.62   1.1804045
                     25749.74   1.2208999    6617.79    5420.42    1.1177096   17535.98    15689.21   1.4954839   6688.97    4472.78    1.1340934   19924.08    17568.29   1.234329    10666.75   8641.74    1.3675512
                     63874.96   1.7075101    34123.36   19984.28   5.118479    141552.5    27655.19   1.3091841   45701.09   34908.07   1.5575881   89753.98    57623.69   1.3657919   49877.6    36519.18   1.3173504
                     26475.73   1.1886692    12615.68   10613.28   3.759955    67525.18    17959.04   1.5167384   16277.88   10732.16 0.75288165    10498.46    13944.37   0.8844142   6079.87    6874.46    1.0430213
                     17573.98   1.5186099    2656.58    1749.35    4.301275    28403.34    6603.47    2.4833543   30909.07   12446.5    1.4767315    8047.95    5449.84    1.8193243   6679.74    3671.55    1.4095286
                     63874.96   1.2729791    41963.3    32964.64   1.9335175   16346.13    8454.09    1.925222    4095.14     2127.1    3.196594    104244.87   32611.23   1.8421954   7167.54    3890.76    1.3028314
                     2327.92    1.4218858    7813.32    5495.04    1.429897     4504.29    3150.08    1.3153569    2840.5    2159.49    1.4443653    2880.31    1994.17    1.4166719   3378.04    2384.49    1.0599451

                     24973.71   1.5075276    30501.85   20233.03   2.0901873   69471.26    33236.86   1.0397654   28328.5    27245.09   1.101377    24221.13    21991.68   0.8014704   11164.49   13930.01   1.0897496
                     32870.53   1.2404679    17434.69   14054.93   1.9977047   24231.06    12129.45   1.1595377   12702.99   10955.22   1.1814767   42150.75    35676.33   1.4263188   25060.85   17570.3    1.1773328
                     28928.67   1.5867554    3684.24    2321.87    19.177176    9332.38     486.64    1.4742385    585.14     396.91    3.8865001    1514.88     389.78    3.474059     356.23     102.54     1.755223
                     6026.18    0.9477665   5727.04    6042.67 0.21675825      1022.75    4718.39    1.125541      837.47     744.06 0.94386804        1336.3    1415.77    0.7320904    421.75     576.09 0.93386626




                                                                                                                                                                                                                    UNCORRECTED PROOF
                     45885.99   1.1537688   19560.06   16953.19   1.3854723   16282.43    11752.26   1.1910259     3529.2    2963.16    0.6894549     5055.69    7332.88    1.1152352   2221.95    1992.36    1.0804068
                     6148.48    0.7981053   5065.63    6347.07    0.2453355    1894.65    7722.69    0.7023867    2396.48    3411.91    0.7861609     4818.16    6128.72    1.0827993   1716.54    1585.28    0.988872
                     47972.94   1.1268404   18966.37   16831.46   5.5392785   48483.31    8752.64    1.6399691    4772.72    2910.25     4.310808    28290.11     6562.6    1.2529392   3758.78    2999.97    1.4914109
                     26329.9    0.9214707   16797.59   18229.11   1.9156957    42675.4    22276.71   0.8306538   16576.55    19956.03   0.7248792    14590.68    20128.43   1.4082503   33185.87   23565.32   1.4109253
                     6848.39    1.177619    3229.95    2742.78    4.3612437    9435.42    2163.47    2.2692714    5188.78    2286.54    2.0651805     3460.21     1675.5    1.2134256   1851.02    1525.45    1.2041596
www.molmed.org



                     63874.96   1.164486    47900.61   41134.55   3.5174325   101305.48   28800.97   0.7518871   22010.93    29274.25   0.9479808    41080.04    43334.25   1.3110117   22246.52   16968.97   1.1368583
                     31484.02   0.9898052   16849.8    17023.35 0.21756981     1441.03     6623.3    1.2746869   30112.11    23623.14   1.6555657    49368.62    29819.79   1.3689315   9746.45    7119.75    1.0092964
                     39015.02 0.76321316    7908.85    10362.57 0.38419995     5297.81    13789.2    1.3857425    8765.39    6325.41    1.0985436    20454.09    18619.28   1.4484007   12490.37   8623.56    1.1315322
                     3892.67    1.3230016   1479.01    1117.92    0.6510951    9157.47    14064.72   0.8845072    1868.38    2112.34 0.84771496       1778.15    2097.58    1.0969949   1528.41    1393.27    0.9996885
                     6481.95    1.6473895   1928.22    1170.47    0.5928177    2331.73     3933.3    1.1843212   10040.51    8477.86    2.1716957    10915.29    5026.16    1.6655936   3575.33    2146.58    1.1969817
                     26351.17   1.3374699   25825.02   19308.86   2.0062432   76222.81    37992.81   0.8875732   24087.45    27138.55    1.011553    20941.95    20702.77   0.7103756   10282.63   14474.92   1.0286725
                     37795.24   1.2852545   12394.84   9643.88    3.0221477   81512.37    26971.67   1.2510991     20431     16330.44   1.0167507    18462.24    18158.08   1.2562104   22437.44   17861.21   1.2208226
                     13010.47   1.2205932   1982.17    1623.94    4.6153584   27271.46    5908.85    1.4444458    5370.19    3717.82    1.2729061     6119.28    4807.33    1.8234074   4756.65    2608.66    1.2573634
                     2346.62    1.7817941   5150.24    2890.48    3.1735542   23092.78    7276.63    2.6960363    4647.67    1723.89    3.2869234     6309.71    1919.64    2.3110096   5793.17    2506.77    1.2725999
                     63874.96   1.5133761   45869.78   30309.57   2.7321343   175095.94   64087.61   1.7386942   63435.51    36484.57    1.199551     77322.5    64459.54   1.3908316   89603.56   64424.45   1.3921431
                     56850.92   1.7000682   32317.31   19009.42   4.551724    106317.34   23357.6    2.5685923   109701.83   42708.93    1.520972    39347.06    25869.68   2.027907    54220.73   26737.29   1.8419749
                     64177.64   1.0994819   18175.25   16530.74   1.9781669   86189.25    43570.26   1.3767039   30359.06    22051.99   1.1743072    29106.52    24786.12   1.3993275   29615.52   21164.11 0.88628894
                     8662.59    0.996667    8420.81    8448.97    2.0638847   25913.25    12555.57 0.93673056     8751.04    9342.11    1.9607079    16645.43     8489.5    0.8399147   4631.13    5513.81    1.0160444
                     3347.81    3.1999075     554.8     173.38    3.0914598    4594.62    1486.23 0.78225344      1007.12    1287.46    0.5464845      383.96      702.6    1.2597965    529.82     420.56    2.2652545
                      7205.5    2.6748064   2937.82    1098.33    0.3850245    1599.18    4153.45    1.9435755     868.72     446.97    1.2634214     1757.95    1391.42    1.9892696   1375.56     691.49    2.779982
                     21027.08   1.0346637   14439.88   13956.11 0.99662566     35838.2    35959.54   1.5354254   15928.09    10373.73   1.3065822    16310.94    12483.67 0.84642124    5457.25    6447.44    1.1179914
                     11272.96   0.9386621   6670.03    7105.89    2.2947557   41648.69    18149.51 0.81019163    12653.03    15617.33   0.7228037     6551.16    9063.54    1.1874673   10432.59   8785.58    1.0054206
                      753.32    3.0005498   2127.99      709.2    9.579272     6915.66     721.94    2.2278123    1300.53     583.77    1.6691564     1651.43     989.38    1.8858771   1499.31     795.02    1.368853
                      2141.3 0.75093204     1152.14    1534.28 0.61574775      3449.93    5602.83 0.91872656       885.68     964.03    1.4495684     1116.82     770.45 0.018890552       3.78      200.1    1.2284939
                     1899.36    2.2964828    793.94     345.72    1.3623861    1058.07     776.63    0.7292165     283.41     388.65    0.8470496     1717.41    2027.52 0.51712835      220.85     427.07    1.1031675
                      644.05    1.1138798    318.28     285.74    1.2529322     678.35     541.41    1.8269855     483.53     264.66    0.9622876      517.73     538.02    2.2167947    360.34     162.55    2.025591
Molecular Medicine




                      9080.8    1.078005    10192.71   9455.16    1.2039462   28540.45    23705.75   1.0397483   10183.43    9794.13 0.79690135       6370.27     7993.8 0.95181584     3690.58    3877.41    1.0193095
                     22072.51   0.8412547   9813.53    11665.35    0.68489    28529.96    41656.27   1.4169205    16374.6    11556.47   1.3604355    27174.21    19974.64    0.89769      10848    12084.35   1.2359071
                     9043.34 0.50053775     4155.81    8302.69 0.52656436      2639.43    5012.55    1.6282978    4613.44    2833.29    1.1976483     11794.5    9848.05 0.40375465     4175.57    10341.85   0.5844457

                     1447.22 0.86861384      519.24     597.78    0.5307021     931.95    1756.07    0.9158698    1635.89    1786.16    1.1915287     1499.92    1258.82 0.37629727      584.48    1553.24    0.4426824

                     3748.08    0.8441901   1651.43    1956.23 0.59868246       1530.4    2556.28    1.3181031    2153.24    1633.59    1.1032943      3200.8    2901.13    1.1414169   2176.18    1906.56 0.97185713

                       698.5    0.8394025    732.79     872.99    1.507457     1369.57     908.53    0.8386624     429.37     511.97     1.248905      647.27     518.27    0.160998      39.62     246.09    0.9868366

                     35472.19 0.93152726    27384.07   29396.96   0.7669149   38211.95    49825.54   0.8985977   17155.91    19091.87   0.8253453    13260.03    16066.04   1.3118218   8246.06    6285.96    1.0212188

                     4270.35    0.9108665   5825.21    6395.24    0.9111484    5263.55    5776.83    1.2767904    6591.66    5162.68    0.9512126     3450.01    3626.96     1.27096    2333.33    1835.88    1.0339252
                     81304.96   0.8461823   35172.92   41566.6    0.7208374   33512.76    46491.43   0.8686051   56142.29      64635     2.270386    145847.05   64238.88 0.55940956    25990.48   46460.56   1.1857282
                      441.54    1.1105025    391.33     352.39    0.6686779     478.76     715.98                                       0.91366595     211.87     231.89                                      2.9941669
                     38218.61   0.719134    15332.75   21321.13 0.46965262     11873.26    25280.94    0.957554    4353.73    4546.72    1.9798107   53114.26   26827.95 0.74176633    5822.25    7849.17    0.9561302




                                                                                                                                                                                                                   UNCORRECTED PROOF
                     68416.54   1.145514    37735.95   32942.37    3.598903    105214.4    29235.13   0.9732712    17458.87   17938.34   1.1976578   25445.33   21245.91   0.6195218   4599.72    7424.63    1.1621562
                     1718.21    1.3778292   1882.28    1366.12    1.0632575     2996.77    2818.48    0.8811593    1241.58    1409.03    1.0293636   1459.02     1417.4    0.6427193    503.05     782.69    1.2448121
                     3320.32    1.5713718   3669.86    2335.45    3.7792478    11193.49    2961.83    1.1737839    1615.96    1376.71    1.5192566   1838.27    1209.98    1.238534    1006.73     812.84    1.3960043
                     25792.04   0.9331393   12042.35   12905.2     1.404563    20167.22    14358.36     1.44593     7186.2    4969.95    1.4034334   10825.44   7713.54 0.69391906     3259.13     4696.7    0.9905353
                      3533.4    0.6955558    928.72    1335.22     0.177529      269.75    1519.47    0.6468251    1533.48    2370.78    1.5788237   4272.96    2706.42 0.63975596      655.43     1024.5 0.64733976
www.molmed.org



                     3446.68    0.6060783   4213.42    6951.94 0.17092796        881.19    5155.33    0.7709753    1223.53    1586.99 0.89525276     2470.45     2759.5    1.0217942   1429.02    1398.54    0.6039446
                     60281.41   1.1451105   9377.31      8189     1.2797676      7681.6    6002.34    0.8870289    1962.17    2212.07    1.0601922   18189.2    17156.51   1.1587262   2633.24    2272.53    1.2103128
                     4215.53    0.8321184   9203.08    11059.82 0.54558265      2868.57    5257.81    0.7609275     5886.2    7735.56    0.7810103   2587.12    3312.53    1.0067854   3359.22    3336.58 0.96489996
                     63874.96   1.2240455   48028.94   39237.87 0.69539976     48610.77    69903.34    1.287377    37915.88   29452.04   1.2795346   82478.21   64459.54   1.158555    18671.63   16116.31   0.8811464

                     2967.32    0.6924964   1444.97    2086.61    0.2114677      690.22    3263.95 0.74265355      4615.57    6214.97    1.0758773   6782.47    6304.13    1.573561    2972.74    1889.18    1.0583786
                     1123.05    1.9996904   1292.32     646.26    0.8414747      763.47      907.3    1.3853565    2193.92    1583.65    1.4355949    169.07     117.77    1.9048011   1572.68     825.64    3.4213135
                      3050.6    1.5254403    807.98     529.67    1.6391188     2319.73    1415.23     1.567976     450.26     287.16    1.8497338   3060.81    1654.73    4.216162     296.86      70.41    1.0169337
                      116.67    1.5460315    277.76     179.66                                        0.96817046    968.49    1000.33    1.172464    1924.67    1641.56    0.7032138    351.41     499.72 0.68336445
                     37075.66   1.2892416   37289.26   28923.41    2.402882    121664.99   50632.94 0.67839664     10292.41   15171.67   2.0186965   37943.66   18796.12   0.899828    5750.18    6390.31    1.1551535
                     39300.48   0.7327209   14029.18   19146.69 0.15568292       2482.9    15948.44 0.84470683     15699.89   18586.2    1.2052327   35802.38   29705.78 0.87443256    15535.92   17766.86   0.8088588
                     72116.05   1.0514141   41667.5    39629.96   0.5504097    20401.06    37065.23 0.65807986     10099.21   15346.48   1.6481217   83563.25   50702.11 0.67011726    12667.71   18903.72   1.031137
                     9198.35    1.2246736    5765.8    4708.03 0.64496803       6153.93    9541.45    0.7923137    4876.12    6154.28    1.031492    11914.63   11550.87   0.5080952   3095.88    6093.11    1.2243097
                     15480.23   0.7567042   6660.73    8802.29    0.7403314     7116.11    9612.06 0.69732857      1574.01     2257.2    1.0754231   17427.48   16205.23   1.2404258   2505.04     2019.5    0.6822616
                     1809.67    0.503308    2756.91    5477.58    0.1573954       494.7    3143.04 0.85820174      2088.64    2433.74 0.99820644     1608.44    1611.33 0.48470578     1637.05    3377.41    0.8162284
                     17299.17 0.67982733    4775.76    7024.96    0.6989465     1815.87    2598.01    1.0426407    2298.71     2204.7    2.7608922   29268.44   10601.08   0.8202125   1335.88     1628.7    1.4642166
                     4494.17    1.1937894   4870.72    4080.05    1.1627486    10575.36    9095.14    0.7871292    6035.99    7668.36    0.9070384   3177.41    3503.06    1.5769758   8871.75     5625.8    1.5941398

                     27849.57 0.72107327    15178.47   21049.83 0.30815634      5670.41    18401.08   1.2454157    8609.92    6913.29 0.68040997     22585.18   33193.49   0.6938832   11261.6    16229.82 0.96068347
                     12288.99   1.6418601   30342.05   18480.29   1.5685378    54842.31    34963.97 0.82903785     19743.32   23814.74   0.7566197   13898.49   18369.19   0.8387263   18274.42   21788.3    1.1507974
                     23497.41   1.1663886   7810.15    6696.01    2.3565881    16611.99    7049.17 0.86511284       2035.1    2352.41    1.0093364   16761.16   16606.12   1.1155461     4508     4041.07    1.4519506
                     48100.42   1.1497128   24704.66   21487.68    3.407667    57384.53    16839.83   1.1033639    33805.18   30638.29   0.8022942   28728.03   35807.35   1.3699083   36063.4    26325.41   1.2849414
Molecular Medicine




                     6201.48    0.8348692   1583.58     1896.8     4.231337     5856.89    1384.17    1.2965264     780.47     601.97    1.8555055   2295.52    1237.14 0.69706875      373.12     535.27    1.3453592

                                8.0228405     80.79      10.07    1.1455747     1751.79    1529.18    1.0987953     277.27     252.34 0.50673765      168.47     332.46    1.8189992     242.8     133.48    0.592517

                     1360.68 0.75396466      987.95    1310.34    0.8753664      782.42     893.82 0.64261603       375.05     583.63 0.35511774      250.01     704.02                                      0.6906316

                     29190.25 0.49489295    18463.96     37309    0.16983332    1590.18    9363.18    0.9762376    3782.95    3875.03    1.179144    23449.13   19886.57 0.73439276    4245.51    5780.98    1.0367318
                     4543.14    1.6075956   6864.53    4270.06    2.9640598    18232.94    6151.34 0.46835977      1483.08    3166.54    1.4343029    5652.1    3940.66    0.8437696   1494.51    1771.23    1.1629869
                     6380.86    0.7829552   5108.72    6524.92    0.4586745     4435.74    9670.78    0.9068869    5799.46    6394.91    0.7220758   2874.23    3980.51     1.14668    1921.01    1675.28    0.7274004
                     1771.57    0.810884    5107.45    6298.62    0.5448977    18055.38    33135.36   1.0672013    4075.93    3819.27    1.1550764   4438.97    3843.01    1.142305    1442.24    1262.57    0.9806967
                     4157.62    0.7535365   1878.22    2492.54    1.3060488     4008.59    3069.25    0.8427962      1307     1550.79    1.1823181   6592.96     5576.3    1.3085258   1113.32     850.82    0.9570438
                                                                  3.3231125      128.97      38.81                                       0.2702232     86.92     321.66
                     31221.07   0.8615238     3706     4301.68    0.6137757    19443.91    31679.18   0.9733401    3014.96    3097.54    1.4087646   6901.89    4899.25    0.6795102   2185.23    3215.89    0.8778221

                     1062.67    0.6950514    546.79     786.69 0.21570657        283.46     1314.1    0.9186405     708.18      770.9     0.77788     634.05      815.1    1.0223157    966.16     945.07    1.0442581
                     3841.13    1.1529158   3561.68    3089.28     0.98625     4792.84    4859.66    0.5332275    446.77     837.86    1.2459663    2582.29    2072.52    0.5899401    501.16     849.51    0.7233876




                                                                                                                                                                                                                   UNCORRECTED PROOF
                       7839     0.6548118   7792.43    11900.26 0.26794034     4246.64    15849.2    0.8310139   6203.86    7465.41 0.71009856      4256.21    5993.83 0.64749056      1466.1    2264.28 0.69083065
                     11082.9    1.2861826   11488.62   8932.34    2.7485354   24315.66    8846.77 0.92986274     4977.36    5352.79    0.8156994     9598.4    11767.08   1.0418105   5631.84    5405.82    1.0799236
                      3445.8 0.66482025      1377.8    2072.44 0.63706994      1924.34    3020.61    0.9864008    800.77     811.81    0.8264276    1705.73    2063.98 0.76718444      304.25     396.58 0.96394306
                       264.2    1.3163029     290.1     220.39    1.5888005     843.24     530.74 0.74721515      255.57     342.03    0.7883667     719.29     912.38    1.0831857    323.97     299.09    1.1854991
                     2766.76    1.1561989   2776.45    2401.36    1.6597655    5402.52    3254.99    1.0245788   4198.97    4098.24    1.0019945    6978.02    6964.13    0.6565872    1927.3    2935.33    0.9811043
www.molmed.org



                     7458.97    0.7732439   3391.27    4385.77 0.78216976      2774.09    3546.66    1.0856863   4153.89    3826.05    0.7047845    4631.71    6571.81    1.1489694   4687.99    4080.17    0.8854146
                     7316.27    0.8173807   2229.79    2727.97    1.2171425    4291.17    3525.61    1.1824976    612.25     517.76 0.86747116      2805.87    3234.54    1.2242953    335.31     273.88    1.3679509
                     19651.23 0.70565736    9884.75    14007.86   1.275857    13841.76    10848.99   0.609805      8441     13842.13   1.1352288    18807.11   16566.8 0.40924224     1956.01    4779.59 0.87518406
                     15155.72   1.1031318   8021.82    7271.86    1.4274062   24823.72    17390.79   1.0065498   4442.79    4413.88    1.2174977    15309.4    12574.48   1.443264    5394.69    3737.84 0.87528837
                     2431.94 0.74254656     2153.14    2899.67    0.4394746     2458.9    5595.09 0.92594165     2183.75    2358.41 0.98633254      2116.65    2145.98    0.8022224    394.91     492.27    0.9160336
                     19416.63   1.3184532   15880.94   12045.13   3.0886862   61653.11    19960.95   1.2509533   6141.28    4909.28    2.0129318    12169.4    6045.61    1.1764531   1746.48    1484.53    1.2114264
                     63874.96   1.7482789   14542.48   8318.17    2.365096    104435.45   44156.96   2.4206228   25529.34   10546.6    1.6431259    31508.93   19176.21   1.7796171   14803.14   8318.16    1.6944753
                     1359.36    1.6470798    1377.7     836.45    1.3114578    4271.09    3256.75    1.7514825    224.47     128.16 0.92251563       605.53     656.39    1.7963393    256.14     142.59 0.75624645

                      293.54    0.9371709    872.15     930.62    1.2960491    1172.73     904.85    1.1499324   1046.45     910.01    1.7907438     533.57     297.96    1.4031848   1036.28     738.52    1.0813006

                     7241.75    1.2148498   7067.28    5817.41    1.4867458   14299.09    9617.71    1.6553522    174.59     105.47                                       1.5590155    114.65      73.54    0.79889804

                      700.08    1.1607345    780.06     672.04    1.611971     3641.12     2258.8 0.99177223      329.07      331.8    1.1556383     403.26     348.95                                      0.9716243

                     7987.91    1.0981472   8382.75    7633.54    0.8077434   11019.34    13642.13 0.57668895    1309.28    2270.34    0.7374124    2409.65    3267.71 0.76082766     1407.09    1849.42    0.9967241

                      821.74    1.2743431    602.28     472.62    1.5458419    3416.79    2210.31    1.1338408    846.14     746.26    1.2512666     948.36     757.92    0.9725731    378.01     388.67    1.0180196

                      397.08    1.1805415    421.17     356.76    0.8476018    1094.22    1290.96                                      0.8918964     850.45     953.53

                     1447.07 0.94662964     3034.27    3205.34 0.58213514     14869.92    25543.76   1.1435881   2141.62    1872.72 0.87991756      2781.34    3160.91    1.1406679   1112.79     975.56    0.9985023

                        422     1.4296278    421.54     294.86    0.5900487     984.39    1668.32 0.77607524      778.45    1003.06 0.77031446       811.95    1054.05    0.6077883    256.59     422.17 0.24350308
                      1686.3    0.7863307    452.84     575.89    1.5059884     675.24     448.37    0.8344787    664.22     795.97    1.3539267     994.08     734.22    0.8123898    221.23     272.32 0.90847415
                       870.4    0.681088     272.19     399.64    5.4317203    1237.02     227.74    1.623474     441.52     271.96    1.0806161      276.4     255.78                                      2.0936034
Molecular Medicine




                     2959.21    1.0544251   2382.21    2259.25    1.236053     9572.18    7744.15    0.8504323    1638.8    1927.02    0.9412569    5032.27    5346.33 0.81693363      797.27     975.93    0.7009645

                     1069.31    0.8376283   1092.15    1303.86    0.998461     2588.56    2592.55    1.1027849    348.48       316     0.3901212     242.71     622.14    1.0489143    164.26      156.6    0.72711587

                     1486.93    0.8586613   2102.75    2448.87    1.3019472    5519.28    4239.25    0.7660696   1052.12     1373.4    0.9533023    2691.02    2822.84    1.1008959    777.86     706.57 0.81500125
                                2.1162105     660.3     312.02 0.81457496       980.96    1204.26 0.33234224       34.65     104.26 0.66729957       333.87     500.33                                      0.97724086
                                1.2004095     82.06      68.36    0.7669249     144.55     188.48    1.0192522    100.59      98.69    0.93873644    166.56     177.43                                      0.89882576

                     14141.87   1.2932541   17677.31   13668.86   1.5019977   12736.64     8479.8    1.6958599   7582.02     4470.9    1.2577204    13319.85   10590.47   1.2881566   7695.95    5974.39    0.9148328
                     19696.17   2.0492823   37035.33   18072.34   3.7459335   58723.24    15676.53 0.96286744    16138.14   16760.5    1.2807338    11516.5    8992.11    2.6888912   26315.13   9786.61    0.8071346
                     16325.78   2.0117998     92681    46068.7    3.0811262   186404.03   60498.67   0.8475029   54763.08   64616.98   1.0545442    31038.61   29433.2    1.058039    53855.28   50901.04   1.4679008

                     3037.01    1.0010338    1917.3    1915.32    2.3147948    4978.73    2150.83    1.4528887   3931.27    2705.83    1.8683033    8082.56    4326.15    1.1821954   3870.91    3274.34    1.0706762
                                0.8498182    348.23     409.77    1.0070095    1887.75    1874.61    0.9827113    823.06     837.54    0.6132577       86.5     141.05    0.6782651    390.64     575.94 0.76885194
                     16993.37   0.8757272   6865.99    7840.33    1.0650989    5962.36    5597.94    1.0533451   3811.15    3618.14    1.2334702    15646.89   12685.26   1.2037653   4861.37    4038.47     0.862483
                      513.78    1.2116649    1299.85    1072.78    1.3389161    2587.79    1932.75    1.0086608     683.64     677.77    0.5976526      408.89     684.16    1.1658885    791.72     679.07    0.9251056




                                                                                                                                                                                                                      UNCORRECTED PROOF
                                                                   4.3255315     362.22      83.74                                       0.7557883      246.78     326.52

                     47579.35 0.73497003     27476.34   37384.3 0.40446588        6151     15207.71   0.8824668   20394.91    23111.25   1.2481444    43188.85    34602.45 0.95714223    13367.64   13966.2    0.8103379

                      485.72                                       1.3379482    1118.11     835.69    0.8485882      382.9     451.22     2.353619      400.28     170.07    1.5388533    253.88     164.98    1.8497359

                     2199.78    0.8792434    3086.32     3510.2    1.1683646    7524.14    6439.89    1.0114926    1803.38    1782.89 0.96884626       2470.19    2549.62    1.2454188   1344.99    1079.95 0.97591156
www.molmed.org




                     1571.53    1.3215281     930.25     703.92    0.9498657    1096.05     1153.9    0.972625      424.58     436.53    1.0000104      967.49     967.48    1.4406307    490.65     340.58    1.3045971

                      433.93    1.0252554     242.76     236.78    1.8448707     722.23     391.48 0.90727884       454.71     501.18    1.4933752      587.21     393.21    0.2595635     52.45     202.07    1.0913675
                      773.03     1.306558     590.12     451.66     1.129404     923.22     817.44    1.1288681     685.46     607.21    1.1337116      591.48     521.72     1.81293     561.12     309.51    1.1811572
                     63874.96   0.9349507    64195.67   68662.09   0.8866267    57026.31   64318.28   1.714967    110846.89     64635    2.3314805    150286.16   64459.54   1.1187232   72084.93     64435    1.3183383
                      430.75    1.0199516     168.19      164.9    0.97560674   4364.64    4473.77    0.7449234      689.3     925.33 0.91118276        1160.2    1273.29    1.1743681    656.46     558.99    0.7777345
                     9991.73    0.8230055    6730.58    8178.05 0.26221094      2158.08    8230.32    0.7805458     3450.2    4420.24    1.0291713     5535.12    5378.23    1.0714947   1586.08    1480.25    1.0553739
                     42537.53 0.96986437     23020.98   23736.29    1.239328    23800.12   19204.05 0.69139254     17465.6    25261.48   1.0831002    25838.44      23856    0.7079438   19460.35   27488.55   0.8028019
                     18694.94   0.8581941    16016.46   18662.98   0.5538659    9034.45    16311.62   1.0648733    4556.54    4278.95     0.655766     8653.96    13196.72   1.1322805   4887.93    4316.89    0.9788654
                     16004.62 0.88376397     5695.85    6444.99     0.760206    5097.09    6704.88    0.997024     5296.66    5312.47 0.71191823       8801.16    12362.6    1.0688586   7224.18    6758.78    0.8584291
                     37193.76 0.81907153     14202.65   17339.94   1.8479853    89022.85   48172.92   0.8267575   24949.96    30178.09   1.1941813    26346.17    22062.12 0.61228395    6270.92    10241.85   0.8042001
                     3700.89 0.96583927      3179.63    3292.09    1.3336049    5450.67    4087.17    1.1427499    3956.12    3461.93    0.8478917     3295.17    3886.31    1.0414286   2730.98    2622.34    0.9557275
                     2481.08    1.0976641    1132.46     1031.7    1.6165481    1886.35     1166.9    1.0792613    1290.98    1196.17    1.1612664     2486.55    2141.24    1.0997607    762.86     693.66    1.2975762
                      121.32    1.2008417    1275.33    1062.03    0.7863237    1265.36    1609.21    1.1012805    1204.14     1093.4    1.6728677      398.36     238.13    0.899175     586.37     652.12 0.98197114
                                                                                                                                         0.16412021       72.4     441.14

                      958.07     1.162405     613.25     527.57    1.4870998     1598.9    1075.18 0.96314824       487.17     505.81 0.42422506        414.54     977.17 0.043197475      23.88     552.81    2.5317163



                       99.58    1.1874329     221.48     186.52    24.775082     224.71       9.07                                       0.9482274      219.05     231.01                                      2.2547896
                     1534.24    1.1069075    1139.34     1029.3    1.0638386    2438.35    2292.03 0.97091764      1348.09    1388.47    0.9681248     1038.43    1072.62    0.7915491    266.38     336.53    1.3826522
Molecular Medicine




                     2313.49    1.1345987    2459.05    2167.33    0.6189283     9515.8    15374.64   1.1118522    3441.36    3095.16    0.9548767     3885.68     4069.3    1.1586297   1475.99    1273.91    1.0907276
                     3798.85    1.7037613    6278.48    3685.07    2.9967484    15317.22   5111.28    0.7869559     2207.6    2805.24     1.182061     2040.19    1725.96    0.7201556    583.11      809.7    0.94941205
                     17330.1 0.75615555      4952.35    6549.38 0.21967609       772.86    3518.18    0.7374605   19169.15    25993.46   1.3156987     38544.5    29295.84   0.3861876   2322.15    6013.01    0.9399354

                     1041.68 0.48056027       547.93    1140.19    0.4705449      792.6    1684.43    0.8438408      720.1     853.36    1.1472205     1191.01    1038.17    0.5630672    787.99    1399.46    1.0070465

                      709.42 0.91337794       961.86    1053.08    0.8287592    2017.78     2434.7    0.9232393     432.99     468.99    1.0611155      703.18     662.68    0.8362957    344.88     412.39    1.2761173
                     2970.61    0.8066315    1826.48    2264.33    0.5164208    2932.64    5678.78    1.0772097    2833.74    2630.63    1.2936721     4694.71    3628.98    0.8593658   1262.46    1469.06    0.9195373
                       19.59    1.4324983     393.98     275.03     2.558744     900.55     351.95    2.0548313     253.71     123.47    0.9827239     1195.12    1216.13    4.4696274     487.1     108.98    1.4240739
                     4064.69    1.3211448     2408.5    1823.04 0.83632696      5818.82    6957.59    1.3791438    3215.86    2331.78    0.7936615     2372.77    2989.65 0.76920426      2233.7    2903.91 0.94373304
                                0.82748157    158.14     191.11    0.9029851     219.01     242.54 0.79631656       275.86     346.42 0.55901814         64.22     114.88    0.2053889      60.6     295.05 0.62397426

                      169.32 0.95224375      1484.11    1558.54    1.0123023    2498.18    2467.82    1.296218       1749     1349.31    1.4699275      925.29     629.48    2.5827982   2320.36     898.39    2.6104093

                     16962.62   1.0330657    13264.43   12839.87   1.6062056    25831.24   16082.15   1.0090271   10644.43    10549.2 0.99930465      12057.44    12065.83   1.2611234   13888.74   11012.99   1.1327846
                     14572.75   1.2192711   15234.23   12494.54   1.8831248   42025.98    22317.15   1.1405921    15623.58   13697.78   1.1288339   19776.13    17519.08   0.9907055   8114.71    8190.84     1.269608




                                                                                                                                                                                                                    UNCORRECTED PROOF
                     12757.79   0.684848    5858.45    8554.38    0.732569     4136.48    5646.54 0.49785316      5921.65    11894.37   1.0614935   23077.75    21740.83 0.53901094    2877.86    5339.15    0.6968595

                       383.2    1.0993627    448.54       408     0.8252314     650.86      788.7    0.77310365     302.5     391.28 0.77134216       170.86     221.51 0.74852633      138.41     184.91    1.0038567

                      474.72    1.2990183    848.09     652.87    1.2689598    2287.63    1802.76    1.1268021     145.38     129.02    1.5084124     291.38     193.17                                      1.0872581

                      646.43    1.025902      685.2      667.9    0.7361192    1349.52    1833.29    0.9249323     823.68     890.53    0.6176796     469.35     759.86 0.011385575        2.3     202.01    1.2860591
www.molmed.org




                      9006.5    0.9313857   6596.39    7082.34     1.30238    18900.79    14512.5    1.1386048    6440.62    5656.59    0.7703631    5260.34    6828.39    0.9071553   5020.56     5534.4    1.0528369
                     1361.08    1.2709315    879.51     692.02    0.6993878    1278.18    1827.57    1.3356061    1006.82     753.83 0.64546794       583.29     903.67 0.37384325      264.61     707.81 0.32103318
                     58602.03   1.390419    57648.27   41461.08    4.42214    154750.98   34994.59   1.2527118    58161.77   46428.69   0.8483172    19120.9    22539.8    1.0113132   20505.72   20276.33   0.8796669

                     1084.98    0.782064     478.24     611.51    0.7473914    1810.04    2421.81    0.5936324     955.95    1610.34 0.72736984      1825.16    2509.26 0.85262674      686.68     805.37 0.68753964

                     1008.92    1.1033685    815.93     739.49    2.216658     1507.66     680.15    1.5030088     369.65     245.94 0.96417516       679.03     704.26    0.3372851    102.42     303.66    1.6631513

                     12136.77   1.1647849   3508.74    3012.35    2.4837646    5459.24    2197.97 0.75065845      2111.94    2813.45    1.3154494   11824.72    8989.11 0.63099325     2787.93    4418.32    1.1915002
                     1890.79      0.9746    1559.36      1600     0.5554879    3118.62     5614.2    1.0780787    1829.92    1697.39    0.9019782    2815.11    3121.04    0.9186022   1715.26    1867.25    0.7717756

                     40826.81   1.1509938   1554.21    1350.32    2.6393073    3395.97    1286.69 0.87817407      1371.26    1561.49    1.1959512    2799.04    2340.43    0.8971524   1445.16    1610.83    0.7664552

                     63874.96   1.3768281   87766.43   63745.38   3.0914001   198833.53   64318.28   0.8370493    19354.06   23121.77   2.952498    166655.94   56445.74   0.9447424   13491.8    14280.93   0.7843571

                      190.71    1.3000984    343.98     264.58    9.420096      217.51      23.09    6.5736175     154.48       23.5    1.1031238     352.79     319.81 0.97811234      231.93     237.12    1.8992667

                     1206.16    1.1369327   2323.72    2043.85    0.4295753    1678.05     3906.3    0.6384603     596.29     933.95    1.130046     1014.77     897.99    1.0765395    785.82     729.95    0.9207149
                     40941.56   1.2587775   13016.3    10340.43   1.7914716   25109.05    14015.88   1.5810727    30084.57   19027.95   1.5224053    34093.4    22394.43   1.2916166   20715.72   16038.6    1.2738332
                     4050.39 0.97383666     1297.91    1332.78 0.38320246      3964.62    10346.02   1.2369071    1580.52     1277.8 0.51512665      1517.29    2945.47 0.88966465     1341.73    1508.13    0.6311918
                     7778.45 0.97417057     8495.78    8721.04    0.7089864   12423.71    17523.2    1.2201686    5335.37    4372.65    0.7104924    3267.81    4599.36    0.6843712    755.58    1104.05     0.823151
                     3466.71    1.2535383   1375.47    1097.27    2.9367843    3893.53    1325.78    0.8880988     203.57     229.22 0.71297675       850.46    1192.83                                      0.96822894
                     6497.28    0.4126176   2826.81    6850.92    0.2331254    1013.48    4347.36    0.8270248     1753.4    2120.13    0.6696154    2773.46    4141.87    1.3739488    663.26     482.74    1.0356771
                     12160.04   1.0547937   6736.44     6386.5    2.9687872   40610.75    13679.24   0.5377716    7665.23    14253.69   0.9759736    2444.56    2504.74    0.959523    8521.14     8880.6    0.8683014
                      576.63 0.94267327     1192.18    1264.68 0.80843204      2803.99    3468.43     1.488265    1549.15    1040.91     1.07898      582.66     540.01    1.1764783    447.25     380.16    1.0659173
Molecular Medicine




                      421.06    1.1342221   1355.94    1195.48    0.9050678    3575.57    3950.61    1.1733068    1061.08     904.35    1.0976976     530.66     483.43    1.2136306    912.99     752.28    0.9468305
                     1363.79 0.75894177        745      981.63    0.4788631     716.02    1495.25 0.95117253       803.95     845.22 0.88027227       979.25    1112.44    1.2924355    812.58     628.72     1.040636
                     5387.62    1.1993926   5979.32    4985.29 0.75683945     22711.26    30008.03   0.8406193    7147.08    8502.16 0.76634395      6664.87    8696.97 0.43070316     2534.46    5884.47    0.8189402
                      428.34    1.0069866   1163.12    1155.05    0.5492706    6811.18    12400.41   1.1661466     971.68     833.24    0.8430067    1057.24    1254.13    1.9575726    672.25     343.41 0.87368083
                     18914.97 0.78245544    12406.88   15856.34   1.2161491    12351.6    10156.32 0.93584687     5099.86    5449.46    0.6747236   12552.18    18603.44   0.4016324    4646.2    11568.29 0.69966686

                     6235.97    1.0439657   12966.44   12420.37   0.8173458   12530.99    15331.32   1.2946799    10846.22   8377.53    0.9239367    4820.88    5217.76    1.1461824    8862.5    7732.19     1.074466
                     7662.22    0.8479032   8958.81    10565.84   1.186453    14754.86    12436.11 0.97368175     8457.77    8686.38    1.3698409   12714.22    9281.53    0.906394    2512.18    2771.62 0.99340874
                     1630.45 0.77495843      1528.9    1972.88    0.4550868    1064.63     2339.4    0.6190819     352.79     569.86    0.7904004    1009.12    1276.72    0.3444224    154.16     447.59     0.900249
                     33196.41 0.81497616    21105.61   25897.21   0.2815507    9433.12    33504.16   1.1019264    34070.11   30918.68 0.79735154    30450.36    38189.38   0.6442804   15594.06   24203.84    0.966572
                      576.73 0.76832986      461.19     600.25    0.4271146     384.48     900.18      3.70834     466.88      125.9    0.4736895     236.21     498.66    1.3133188     381.9     290.79    1.3917593
                     17024.72 0.59605896    9398.08    15767.03 0.24938326     5307.16    21281.14   0.5921721    3129.57     5284.9 0.80700177     10154.02    12582.4 0.46608657      775.61    1664.09    0.6622827
                     2479.24    0.9938267    5863.26    5899.68 0.31824312      1420.65    4464.04    0.9476709   1561.61    1647.84    1.0092914   1633.75    1618.71    1.7807978    2202.01    1236.53    1.0145861




                                                                                                                                                                                                                    UNCORRECTED PROOF
                     10254.18 0.55994695      6206.9    11084.8    0.5646686    6186.43    10955.86   0.7265764   3911.96     5384.1    0.6394428   6251.18    9775.98 0.46213537        827.8    1791.25    0.9307259

                     11763.52   0.9498255      14903    15690.25   0.6647559    23573.76   35462.28   1.2015325   13125.3    10923.8    0.827406    9860.52    11917.39   1.0862526    6528.41    6010.03    1.0316257
                     8157.15    0.8403724    4970.87    5915.08 0.21598004       2762.7    12791.46   0.8845623   4292.33    4852.49    0.8568677   4795.22    5596.22    1.2053986    5786.07    4800.13 0.92214763
                      915.07 0.57438004       490.13     853.32 0.69897753       976.22    1396.64    1.3860624   1023.51     738.43    2.4517658   1874.62      764.6    0.6661764     430.27     645.88 0.94315916
www.molmed.org



                       31.58    0.82401323     40.08      48.64    0.47389707    127.72     269.51 0.68052685      112.11     164.74    0.6456652    163.25     252.84     1.232651      24.69      20.03    0.68765485
                     6010.46    0.7022502    6659.53    9483.13 0.13918799        782.7    5623.33    0.8906004   4878.21    5477.44 0.44709188     1226.06     2742.3     1.072047    2855.59    2663.68    0.9486886

                      575.72    0.9626326    1117.01    1160.37 0.67234266        574.1     853.88    1.3298676    684.27     514.54    1.4908879    740.36     496.59    1.2040446     590.62     490.53    1.0359359

                     8428.42    1.3417399    13677.75   10194.04   0.5417501    21135.86   39014.04 0.43431515    10537.85   24263.14 0.81471765    6987.23    8576.26    1.0973696    5341.04    4867.13    1.5027541
                     5278.01    1.4675704    1636.84    1115.34    1.6949003    5053.04    2981.32    1.1900944     860.7     723.22    1.450488    4268.09    2942.52    1.3219411     695.46     526.09     1.041083
                     36337.69   0.8016143    9451.85    11791.02 0.95052797     7730.53    8132.88    1.2680762   2719.96    2144.95    1.1408317   25658.15   22490.74    1.180694    1082.72     917.02    1.0611002

                     1752.52    0.9948222    2405.49    2418.01    0.4940734    1214.63     2458.4    1.0703559   1840.98    1719.97    1.2863908    2243.8    1744.26    1.1450268     680.02     593.89    1.1587827

                      8612.1    0.8194259    4792.24    5848.29 0.59516895        839.7    1410.86    1.2232949    699.48      571.8    1.0026263   5008.77    4995.65    1.5486637     278.14      179.6     0.846713
                     42737.97    1.220495    31113.48   25492.51   1.4320632    42877.09   29940.78   1.1324327     30848    27240.47   2.203553    44630.74   20253.99   1.0949821    38282.59   34961.84    1.321864
                     1288.55    1.4185724     562.01     396.18      1.22506    1108.52     904.87    1.1216869    756.69      674.6    1.4874445    1533.6    1031.03    1.1314912     620.77     548.63     1.614224
                      174.88                                                                          1.8175285    141.64      77.93    2.1794403    545.71     250.39
                                0.50215036    173.97     346.45    3.2742906     533.12     162.82 0.98894376      934.72     945.17                                      0.98868436    463.08     468.38    1.1033242
                     1745.98    1.0105026    1237.32    1224.46    0.8359257     538.52     644.22    1.2433355    655.76     527.42    3.6215696   1558.47     430.33    1.4269702    1136.81     796.66    1.0124611
                     51612.25   1.4242401    23921.78   16796.17   1.6676396    56486.27   33871.99   0.8887058   8204.07    9231.48    0.8227722   33063.34   40185.29   1.7846361    26419.7    14803.97   1.7166471
                     1613.58    0.9520894    1017.06    1068.24 0.87015676       2046.6    2351.99    0.8910845    1324.9    1486.84    1.0961667    903.34     824.09 0.38771275       158.78     409.53    0.9702453
                      1099.1 0.70712966       631.29     892.75    0.8832742     726.97     823.04    0.8009955    437.72     546.47 0.86844313      1524.3    1755.21    0.6397221     477.93     747.09 0.90972567

                     5180.83    0.9068402    3782.53    4171.11    1.8312685    8138.03    4443.93    1.0263245   3322.12    3236.91 0.76971245     2250.87     2924.3    0.8916186     946.15    1061.16    1.0764267

                     5621.61    1.2801268    4440.44    3468.75    2.7193024    8405.31    3090.98    1.1491905   7719.09    6716.98 0.45844525     3182.66    6942.29     0.795005    3775.28    4748.75    0.6661264
                     4205.91    0.7776859    2114.87    2719.44 0.45888987      1263.98    2754.43    0.8368421   2132.14    2547.84 0.85991794     3346.62    3891.79 0.92898643      2898.67    3120.25    1.1785195
Molecular Medicine




                     11833.54 0.85133904     9870.17    11593.7    2.4765174    25024.59   10104.75 0.78837967    2063.56    2617.47 0.55845803     2888.49    5172.26    0.5320151     951.61    1788.69 0.81495684

                     2313.39 0.74402535      1993.11    2678.82    0.8370397    2313.67    2764.11    1.2142618   2098.05    1727.84 0.68005234     1507.54     2216.8 0.49802223       175.01     351.41    1.1564426

                      865.92 0.78590053       569.66     724.85    1.0950524     945.95     863.84    0.6927265    486.01     701.59 0.74740523      815.18    1090.68 0.19389752        44.61     230.07    1.0669421

                     3260.97    0.7405684    1107.72    1495.77 0.42954302       366.95     854.28 0.92776906     2020.18    2177.46 0.74624914     1816.93    2434.75 0.78504145      1666.91    2123.34    0.9505725

                     1087.31     0.558239     905.62    1622.28 0.37581357       362.04     963.35    1.0339578    783.13     757.41 0.31739545      222.91     702.31    1.0158846     207.85      204.6    0.7657994

                     63874.96   1.0871446    32707.9    30086.06    4.063271    69812.48   17181.35   2.0192368   5614.67    2780.59    4.2632957   101858.7   23892.01   1.2745248    12366.51   9702.84    1.4497269

                     3099.67    2.9887378    1379.96     461.72    4.5002537    3902.08     867.08    1.8595306   4138.85    2225.75    1.6340919   5062.58     3098.1    2.5458663     910.86     357.78    1.5465107

                     13199.29   1.3939297    8143.49    5842.11    2.5301242    35129.13   13884.35   1.4325147   8913.35    6222.17    1.6255146   13620.09   8378.94    1.2816921    5474.44    4271.26     1.038741

                      5632.4    1.1953226    4138.96    3462.63    0.7096871    2523.69    3556.06    1.2869025   2768.05    2150.94    1.3537927   7099.18    5243.92    1.4257755    2012.81    1411.73    1.3953497

                     40501.46 0.99579155     19487.56   19569.92   3.2487977    24587.78   7568.27    1.2494347   3100.31    2481.37    2.520686    53389.77   21180.65   1.9138668    6763.49    3533.94    1.9378897
                     3093.68    1.7745048   3616.92    2038.27 0.17851436       1214.61    6803.99 0.35612458     3145.67    8833.06 0.44298667      1675.73     3782.8 0.49511775       734.73    1483.95    1.2821447




                                                                                                                                                                                                                     UNCORRECTED PROOF
                     24300.41   0.9877446   13030.9    13192.58   0.2873402     5564.34    19364.99   0.9094809   10674.05   11736.42    1.856294    10426.34   5616.75 0.94024915      4308.88     4582.7    1.0773047
                     24289.87   1.342303    9841.31    7331.66    4.6411867    15509.22    3341.65    1.3386488   1955.94    1461.13    1.4215821    19731.8    13880.17   1.1216586    3164.12    2820.93    1.1426765
                     55045.76   1.5261586   88913.83   58259.89    8.098778    157023.25   19388.51   1.2560147   55797.11   44423.93   1.1540158    28259.71   24488.15   1.4363866    52512.8    36558.96   1.0545112
                      2774.4    2.4923837   2509.98    1007.06    1.3916095     2719.72    1954.37    3.2849061    313.61      95.47    0.92741394    590.03     636.21    2.730069      611.59     224.02    0.9463979
                                0.9529772    230.63     242.01 0.50466335       1196.91     2371.7    0.8361908    147.78     176.73 0.56517285        82.73     146.38                                       1.5845318
www.molmed.org




                     2777.99    0.411979    1152.47     2797.4 0.22823323        662.73    2903.74    1.0821446    639.45     590.91    0.5780573    1967.84    3404.23    0.3844827     370.03     962.41 0.75054854
                     2875.62 0.93158996     2778.29    2982.31    1.0711596     7784.76     7267.6    1.1511629   3579.84    3109.76    1.0197806    2754.56    2701.13 0.77693975       518.18     666.95 0.99839157
                     6853.89    1.1491271   5339.27    4646.37    0.9595207    10391.12    10829.49   1.0868229   1328.63    1222.49    1.2550242    4109.79    3274.67    0.3445867     280.69     814.57    1.0954592
                     6917.38 0.99159724     6912.96    6971.54    0.8021268     8653.85    10788.63   1.0166287   2007.12    1974.29    0.9543268    5078.45     5321.5    1.0865548     1416.9    1304.03    0.7921907
                       39.61                                      0.9649189      434.31      450.1    1.0516926    478.11     454.61    1.1849793     443.68     374.42    1.3476809     274.59     203.75    1.1182796
                      429.11    1.1217595    556.46     496.06    0.9670591     2263.75    2340.86    0.9985492    529.96     530.73    1.1616364     459.16     395.27    11.491687     193.52      16.84    0.7647003
                     63874.96   0.8721421   57344.92   65751.81   0.7999562     45095.6    56372.59   1.0453306   52127.4    49866.9    1.1252153    72530.86   64459.54   0.8404996   26627.91    31681.05   1.0725079
                     25383.76   1.1040565   13300.69   12047.11   3.1243408    47589.18    15231.75   1.009218    10375.86   10281.09 0.75398135     10939.81   14509.39   0.6643124     8756.7    13181.6    1.0442864
                     3256.65    1.1999427   4479.41    3733.02    2.4830456    13263.61    5341.67    1.0830028   2850.81    2632.32 0.62499756      1931.23    3089.98    1.8826402    3495.95    1856.94    1.2742579
                     1949.18    2.5469255   3488.32    1369.62    1.9802729     2703.31    1365.12    1.5826472   5556.12    3510.65    1.7235281    3591.35    2083.72    1.6507568     2261.9    1370.22    1.5123812
                     18899.97   1.3125536   38006.92   28956.47   1.4525046    53524.05    36849.49 0.77599245    19607.8    25268.03   0.6025849    17241.02   28611.77   0.6980063   13286.18    19034.47 0.87327945
                      9737.5    1.1859001   5624.06    4742.44    3.4743962    17484.55     5032.4    0.5846562   3072.76    5255.67 0.88038105      6686.38    7594.87    1.0590501    3776.53    3565.96    0.8836518
                      3458.6    0.8090042   4177.01    5163.15    2.7285633    12018.83    4404.82 0.90382653     3918.82    4335.81    0.6404755    1908.79    2980.27    0.7457977     748.05    1003.02      1.19356

                     12367.64 0.93893754    2133.36     2272.1 0.60937065       4526.32    7427.86    0.912788    1879.54    2059.12    1.2653162    4952.22    3913.82    1.1097403    2007.52      1809     0.86634135

                     3946.32    1.478747    1764.16    1193.01    0.7740537      655.19     846.44 0.87101275     3340.09    3834.72    0.8670065    4121.35    4753.54    0.8657097     874.54     1010.2    1.5666195

                                                                  0.46369916       62.4     134.57 0.33906847      200.42     591.09    0.8204036     211.82     258.19
                     1112.95    1.1743904   2137.32    1819.94 0.61103565       2416.42    3954.63    0.8572824   2879.32    3358.66 0.93900025      1920.34    2045.09    0.7789315    1900.85    2440.33    0.8444171
                     57620.64   0.8870951   56983.08   64235.59   0.9844849    63320.38    64318.28   1.5819628   91768.84   58009.48   1.4809716    68799.67   46455.77   1.6021228   103232.78     64435    1.4026933
                                1.2883945    192.28     149.24    2.9804308      976.24     327.55    1.0060134    214.14     212.86                                       0.375206       523.6     1395.5    0.8247565

                     5244.82    0.6478628    3277.7    5059.25 0.93515635      12849.02    13739.97   1.1969495   1646.44    1375.53    1.0565139     1980.9    1874.94    0.2297251     469.31    2042.92    0.8994541
Molecular Medicine




                      2468.3    2.3780096   2507.73    1054.55    6.0212197     4894.71     812.91    1.9958972   2670.73    1338.11     2.970219    2961.16     996.95    2.365883     2526.29     1067.8    1.0818863

                     10418.09 0.85475796    11397.71   13334.43 0.70632696     21752.04    30795.99   1.1499534   11742.6    10211.37   1.1384176    11040.42   9698.04    1.2293813    4717.21    3837.06    0.9743569
                                                                   1.127127      371.58     329.67                                      1.6004553    2861.39    1787.86 0.62744415       108.46     172.86    0.8229847
                     21291.98   0.5748319   5081.79    8840.48    0.4106239     5085.24    12384.18   0.6629566   1140.04    1719.63 0.63424486      7662.94    12081.99 0.62180436      903.83    1453.56    0.6300782

                                0.6726391     67.95     101.02    0.7814474     1446.17    1850.63    0.2707402     93.89     346.79    0.8387725     223.86     266.89 0.22890124        42.04     183.66 0.72637624

                      681.06    1.3190389   3010.35    2282.23 0.83728045      14825.39    17706.6    1.018132    3892.39    3823.07    1.0620131    1758.63    1655.94    1.2467777    3071.05    2463.19    1.0247259
                     2910.12    1.0715629    5698.1    5317.56     2.295916    13322.19    5802.56    1.340536    2782.39    2075.58    0.8591038    2080.99    2422.28    1.5511423    2967.63    1913.19    1.0916274
                     29361.55 0.83119696    17061.34   20526.23   0.4176722    14993.17    35896.98 0.52606696    13492.86   25648.56 0.94573206     26372.77   27886.09   0.4090461    3220.06    7872.12    0.9275667
                     10826.38   0.7812987   5988.03     7664.2     2.376141     8366.82    3521.18 0.83844024     2142.24    2555.03 0.43495855      1141.44    2624.25    2.1269913     862.58     405.54    0.9501825
                      391.07    0.629526     560.19     889.86    1.2398802     1580.81    1274.97                                      0.57584673    334.78     581.37 0.11289482        15.19     134.55 0.83110905
                     18825.9    1.0235907    12033.26   11755.93   1.5875958    30716.31    19347.69   1.1236784   13358.75   11888.41   0.9601324     5705.99    5942.92    1.2948315   4591.11    3545.72    1.4539379




                                                                                                                                                                                                                      UNCORRECTED PROOF
                      395.72    0.8111655     652.68     804.62    0.6390165      534.32     836.16    1.0870761     454.3     417.91     0.824705      689.94     836.59    1.6592256    240.82     145.14    0.8354574
                     2457.28 0.85875607      5308.04    6181.08    0.9507654      6686.2    7032.44 0.38098314     2258.51    5928.11 0.42652693       3256.93    7635.93    0.6198839   2465.21    3976.89 0.56544423
                      213.86 0.53931206        48.29      89.54    0.48990577     160.16     326.92    1.2459314    143.93     115.52    1.3056684      273.42     209.41    1.3204014     88.15      66.76    0.88742137
                      101.93    1.0595219      269.5     254.36    1.0367556      930.26     897.28    2.2297697    233.39     104.67    1.3495417      135.44     100.36                                      1.2655708
                     59812.93   1.3472916    39395.41   29240.45   1.5430398    56208.43    36427.08   1.8640896   13780.04   7392.37    1.2620246    17505.86    13871.25   1.0112691   7210.47    7130.12     0.773811
www.molmed.org




                                2.7413661      318.3     116.11    1.6872547       64.47      38.21    1.7893635    264.79     147.98     0.850788      231.04     271.56    1.6066921    367.82     228.93     1.396372
                     40627.8    0.8173724    30281.53   37047.41 0.14807594      6607.36    44621.43   0.8772473   32060.66   36546.89   1.4687487    35438.26    24128.2    0.7595354   12224.38   16094.55   0.8730724
                     15777.88    1.320792    15449.66   11697.27 0.23400624      6521.48    27868.83   0.6121623   12770.6    20861.46 0.80405533     30105.63    37442.24 0.67456955    7255.09    10755.14   1.9864236
                                0.71006745    620.18     873.41     2.652243      867.31     327.01    0.9778023   1517.51    1551.96    1.0027583      250.85     250.16    1.0937132    686.48     627.66    0.9741937
                     8750.75    0.6128939    5293.92    8637.58     1.430226    16840.41    11774.65   0.9356078   6597.99    7052.09    1.8784083    10148.42    5402.67 0.79984903     4142.77    5179.44 0.90960675
                     6792.03    1.1524949    2606.01    2261.19     1.326347     1691.57    1275.36    1.000726    5169.37    5165.62    1.2575009    13718.14    10909.05 0.76951987    1236.88    1607.34    1.3076105
                     1262.12    0.9335361    1906.15    2041.86 0.96366245       4325.37    4488.47    0.8816536    811.28     920.18     0.553835     1032.57     1864.4 0.61900395      782.52    1264.16    1.1216097
                     34584.87   0.9649378    25656.75   26589.02   3.6270874    65296.35    18002.42 0.74502295    2067.99    2775.74    0.8676638     8354.96    9629.26    1.2299396   3018.37    2454.08 0.75531447
                     10380.39   2.1450922     7492.4    3492.81     2.068848    18107.84    8752.62    2.391727    18910.38   7906.58    5.6035423    31193.74    5566.79    3.1927092   7635.14    2391.43    0.9335253
                                1.5230832     110.85      72.78    0.06711955      36.36     541.72                                      0.64351094     273.46     424.95                                      0.36024842
                     85101.34   0.8617093    29350.67   34060.99   0.1977425     7655.26    38713.27 0.77511454    14297.84   18446.1    2.1155849    84349.16    39870.37   1.060985    19410.39   18294.69   1.0234585
                     4016.34     1.055024    3210.47    3043.03 0.79608804       7514.02    9438.68 0.76713115      3735.1    4868.92     0.843697      5176.9    6135.97    1.1235414   2329.82    2073.64    0.7662742
                      416.08    1.3447949     170.13     126.51    1.4732199      322.37     218.82 0.49812248      111.43      223.7    0.77876186     364.92     468.59    0.9926353    254.74     256.63    1.1257172
                       2056      1.069228    7155.05    6691.79 0.83880764       7578.87    9035.29 0.91562104      2531.5    2764.79     1.569632     3246.36    2068.23    1.0864937    2199.9    2024.77 0.93265265

                     1557.43    1.1912774     503.41     422.58     1.211397      710.23     586.29    2.167136      415.7     191.82    2.5751677     1060.66     411.88    1.7622201    335.28     190.26    1.4828395
                     7572.65    1.2577165    19910.03   15830.3    1.2216953    34530.24    28264.2 0.52517396     5275.21    10044.69 0.80271655      5723.65    7130.35    0.8205529   2099.04    2558.08 0.86638296
                     13822.48   0.7580866    3819.43    5038.25    0.3471451     2765.83    7967.36    0.7983198   1497.64    1875.99    0.9057708     8807.38    9723.63    1.0586747   3222.32    3043.73    0.6634733
                     15838.83 0.89806485     10638.18   11845.67   1.2274255    19448.15    15844.67   0.8599726   5172.95    6015.25    0.5629041      6605.1    11733.97 0.92749953    1277.51    1377.37    1.0065026
                      1154.4    0.72717595    935.97    1287.13 0.51762974       1416.38    2736.28    1.5236057   1337.68     877.97    1.0527455     1128.68    1072.13    2.1709418     670.3     308.76     1.285512
                     7378.09 0.98753846      3494.78    3538.88 0.38697746       2621.13    6773.34    1.1588385   4184.96    3611.34     3.773396    15558.73    4123.27    1.1987158   3879.44    3236.33    1.4969425
Molecular Medicine




                     2946.74    2.1347294    10973.64   5140.53    2.9088266    26386.43    9071.16 0.72282577     5476.33    7576.28     1.137562     4773.54    4196.29    1.0524095   8418.36    7999.13 0.88482994
                     63874.96   1.5100043    59232.5    39226.71   3.4653792    66365.34    19150.96   4.923694    43431.66   8820.95    5.4453244    114932.45   21106.63   2.1400964   12088.57   5648.61    1.9872223
                      377.95                                                                           1.4178559    151.03     106.52 0.66595733        334.85     502.81    0.9482724    186.07     196.22     1.303383
                     6272.06 0.39408505      1749.45    4439.27     0.953338     4852.51    5090.02 0.68452185     2102.55    3071.56 0.83764875       2723.33    3251.16 0.19970007      218.39    1093.59    0.8051355
                      3350.3    0.8425191    1237.45    1468.75    1.2852858     3518.29    2737.36    1.0574205   1363.66    1289.61 0.66282874       1385.69    2090.57    1.0069002    742.75     737.66    1.9060006
                     5205.03    1.3744016    4798.97    3491.68 0.80889565       5658.12    6994.87 0.66197497      1074.2    1622.72    1.0475317     3236.37    3089.52 0.72545695     1258.53    1734.81    0.7105731
                       67.87    0.84692717     178.6     210.88     0.750677      839.91    1118.87                                      0.80188656     272.04     339.25                                       16.38328
                     31268.19   1.1117147    47541.6    42764.21   2.2401927    143818.38   64199.11   0.833457      49271    59116.43   1.1068152    37586.63    33959.26   1.1464921   44342.49   38676.66   1.1220844
                      570.15    0.9033617       463      512.53 0.98064893       2364.57    2411.23    1.150727     460.59     400.26    2.4673064      426.77     172.97    0.8768764     54.91      62.62     1.738012
                     25301.82   0.7777686    10961.56   14093.6     0.666962    10177.32    15259.22   0.5724959   1429.82    2497.52    0.9551836    13177.79    13796.08   0.2905869   1576.46    5425.09    0.6592179
                     2325.64    1.5745668     793.44     503.91    3.2776976     1520.36     463.85    1.2705127    429.23     337.84    1.2748026      1152.6     904.14    1.6467578   1068.96     649.13    2.9966264
                     24375.31   0.9311345    22209.56   23852.15   3.9873638    39979.34    10026.51   1.3904557   12739.05   9161.78    1.4210738    10160.99    7150.22    1.514079    8286.66    5473.07     1.669915
                      422.23    1.6500806     828.72     502.23 0.62857765      2094.49    3332.11    1.0804014      442.5     409.57    1.0566177     710.1     672.05    2.312897     597.19      258.2    1.0498655




                                                                                                                                                                                                                    UNCORRECTED PROOF
                     28632.87   0.8527409    11094.27   13010.13   1.2535008    8755.34    6984.71    0.6770767    2374.63    3507.18    1.1383508   21156.83   18585.51 0.65791416    3542.21      5384     0.94212055
                      865.63 0.45850798       374.17     816.06         0.01       9.36    1083.17    1.3640627     587.42     430.64 0.37133148       545.2    1468.23    1.6892855    436.41     258.34    1.1288009
                     10040.01 0.86717445     7253.42    8364.43    1.9899911    14897.85   7486.39    0.8300506    5287.19    6369.72 0.97563434     5376.75    5511.03 0.81646246     1371.02    1679.22    0.9704367
                     2918.91 0.52877337      3704.01    7004.91 0.18322533       502.73    2743.78    0.8227647    1280.37    1556.18 0.58018875     1978.96    3410.89    0.9004832   1511.29    1678.31 0.91185087
                                0.59265304    141.65     239.01 0.31412423       192.31     612.21    1.7018466     411.03     241.52    0.637985     140.58     220.35    0.997724     153.43     153.78    0.9141864
www.molmed.org




                      755.12    1.6443079     633.93     385.53    1.4816113     833.11      562.3    1.3082811    1798.35    1374.59    1.2578471   2089.07    1660.83    1.298326     900.48     693.57    1.3179089
                     4510.17    0.6454783    4736.52      7338     0.5999112    1298.07    2163.77    0.7788082    1312.65    1685.46    1.488622    1893.14    1271.74 0.94234073      965.56    1024.64    0.9215379
                     8900.69    2.5999038    10909.43   4196.09     2.206495    3276.27    1484.83    0.8552157    1345.28    1573.03    2.8924549   18434.54   6373.32    1.2006812   2125.83    1770.52    1.9257163
                     33004.36   1.6230278    29036.78   17890.5     2.195713    28219.02   12851.87   0.8477525    11302.83   13332.7    0.8916262   36935.07   41424.39 0.95476276    25580.89   26792.93   1.2555568
                     18452.06 0.89128405     12028.52   13495.72   0.7917059    29295.17   37002.59   1.3072083    11566.01   8847.87    1.0055033   17779.56   17682.25   0.9942735   5321.64    5352.29 0.99973255
                      325.94    1.3149738      70.43      53.56    0.79335797   1224.08    1542.91     1.117349     621.95     556.63    1.3481991    556.24     412.58    1.4496447    283.42     195.51    1.0950935
                     40394.62   0.5774956    22253.26   38534.08 0.28849506     12454.99   43172.28   0.7488409    15075.92   20132.34 0.77168417    37363.79   48418.5    0.9738116   36994.45   37989.33   0.7992697
                     63874.96   1.2175578    30965.43   25432.41   3.2137945    37529.89   11677.75 0.99057275     3447.53    3480.34    1.7588354   39841.88   22652.42   1.0883975   5017.24    4609.75    1.1869258
                      6857.9     1.065859     2030.6    1905.13    1.4520161    5459.29     3759.8    0.8576315    1855.46    2163.47    1.0354608   2532.82    2446.08    1.0070245   1274.45    1265.56    0.7573659
                      2481.4     0.822583     854.31    1038.57    0.6065363    1378.73    2273.12    0.6372888      93.93     147.39    0.8709706   2179.36    2502.22    0.7221596      378      523.43    0.9763993
                     2571.74    0.8782956    3591.86    4089.58    1.1733626     4186.3    3567.78    1.0826275    2477.42    2288.34    1.0025996   1824.24    1819.51    1.0518891   1732.03    1646.59    0.8557237
                     2128.45    1.6747802    3465.69    2069.34    1.0566365    12504.33   11834.09 0.74099386      847.86    1144.22    1.1599205    869.72     749.81    1.0116547    451.37     446.17    1.0657626
                     8311.05    0.9299041    6588.25    7084.87    2.0425808    10407.99   5095.51    1.0696508    3709.72    3468.16    0.7303787   10324.37   14135.64   1.0002626   4532.55    4531.36    1.2091242
                     6176.53 0.80384606      2864.16    3563.07    1.8504214    4856.69    2624.64 0.71780634      2948.16    4107.18    0.8767416   3181.02    3628.23    0.7222523    880.18    1218.66    0.9269599

                     7654.77 0.84665805      2888.01    3411.07    1.2397919    30065.25   24250.24   1.4787003    1299.26     878.65    1.2298124   8544.38    6947.71    1.1774601   1310.36    1112.87     1.152484
                     7386.01    0.9778626    7715.14     7889.8    1.3010888    24103.32   18525.5    1.2162192     3836.6    3154.53    0.8760628   3385.79    3864.78    0.5994101    508.09     847.65 0.87969977
                     2534.08    0.6461399    1316.62    2037.67 0.93152463       2828.5    3036.42    1.3163548      759.8      577.2    1.0476601   1237.58    1181.28 0.96452904       89.19      92.47    1.3935058
                     16148.54 0.50125295     6925.12    13815.62   2.5481837    43770.97   17177.32 0.60715735     19888.58   32756.88 0.71927905    16897.67   23492.51 0.27711555    2990.95    10793.15   0.8526878
                      209.84    1.4807684      369.2     249.33    1.6219918      544.6     335.76 0.37975174        78.32     206.24    1.5586659    721.07     462.62                                      2.0452547
                     4396.77    1.0630052      2167     2038.56    1.0070872    3484.24    3459.72     1.361253    6144.07    4513.54    1.6552378   9489.23    5732.85    1.4593031   3904.03    2675.27    1.1688012
Molecular Medicine




                     63874.96   1.4237015    42477.93   29836.26    3.611729    97008.62   26859.33     1.38301    15549.39   11243.15   1.1387591   35978.89   31594.82   1.4345824   24986.94   17417.57   1.2815218
                     7097.12 0.75869143      1967.78    2593.65 0.23675165        72.33     305.51    0.9737694     959.64     985.49    1.5732598   8846.88    5623.28    1.5432674    610.64     395.68     1.047619
                     6347.29    1.0703222    8655.77    8087.07    1.5617915    9694.04      6207     0.95810425   3873.05    4042.41    1.0332507   5308.15    5137.33    1.2881007   5405.36    4196.38 0.95240104
                     51133.27   2.0512908    8756.14     4268.6     8.317447    39123.69   4703.81    2.8149393    7282.53     2587.1    3.093338    27260.63   8812.69    1.9293406   8602.37    4458.71    2.8925016
                      2108.5    1.0212711    1292.96    1266.03    1.6316833    7918.69    4853.08     2.202967     2462.3    1117.72    1.7071276   1291.92     756.78    3.0315537    984.77     324.84    1.1495235
                     7553.06 0.87211466      6130.39    7029.34 0.86549026      9866.39    11399.77   1.4805251    9491.69    6411.03    1.7459542   11664.51   6680.88    1.0442543    5835.7    5588.39    1.1545426
                     39283.39   1.3395225    3985.91    2975.62    3.4588912    28799.8    8326.31    1.8167223    87329.93   48070.05   1.3104546   20500.45   15643.77   1.0380663   9323.85    8981.94    1.4573008
                     55395.88   0.7804705    16438.02   21061.68   0.6457004    13212.8    20462.74   1.0329593    61292.17   59336.48   1.0597384   38004.49   35862.14 0.75575507    16168.76   21394.18    0.973426
                     11881.19   1.2925613    16948.93   13112.67   1.9109765    45808.55   23971.28 0.67290854     7655.64    11376.94   1.4965242   12229.97   8172.25    1.3297968   3986.97    2998.18    1.0516859
                      9519.1    1.1151512    11682.39   10476.06   1.3106334    18444.78   14073.18    0.837445     9526.8    11376.03   1.7735821   15058.67   8490.54    0.9215957   3629.29    3938.05    0.9699452
                     8095.06 0.68593866      3510.25    5117.44 0.80581415      1957.25    2428.91    1.0523973    1168.34    1110.17    0.9799923   4845.16    4944.08    1.0923436   1185.16    1084.97    1.4786706
                                                                   1.4121482    1782.47    1262.24                                       0.5247077    166.92     318.12    3.3201475    234.17      70.53    0.99165744
                     3995.73    1.7896551    3968.56     2217.5     9.045836    14270.08   1577.53    2.5463715   1441.45     566.08    1.1501576    2481.58     2157.6    2.1431444    3015.64   1407.11   1.9238733




                                                                                                                                                                                                                   UNCORRECTED PROOF
                     21740.06   1.7238077    7680.77     4455.7     3.888433    27922.33   7180.87    1.2885408   9231.48    7164.29    1.5028212    6523.04    4340.53    1.7832371    7462.83   4184.99   1.3452647
                      172.66     2.334998      60.78      26.03    0.81345016   1118.86    1375.45    0.6275229    142.09     226.43    2.4688177     193.58      78.41    0.44537857    83.17    186.74 0.13495208
                     2636.76    1.1518772    2383.28    2069.04 0.76543033       5400.7    7055.77 0.83228636     3125.46    3755.27    0.8760945    5793.07    6612.38     0.884639    1625.71   1837.71    1.002815
                                                                   0.4445251      91.87     206.67 0.47016084      115.18     244.98 0.33901978        64.19     189.34
                     2527.59    0.5752241     3124.6    5431.97    0.1313965     480.09    3653.75 0.73211634     1252.08    1710.22    1.2139672    2101.11    1730.78       1.1221    338.56    301.72    1.0128826
www.molmed.org




                      590.02    0.8049687     801.29     995.43    1.2244467     594.53     485.55    0.8471444    403.91     476.79    0.9305958    1028.69    1105.41     1.404041    400.25    285.07    1.2796612
                     1290.89    1.2571716     761.67     605.86     1.343813    1248.55     929.11    1.0186825    856.06     840.36    1.6742991    1454.38     868.65 0.69131625      308.41    446.12    1.0182054
                     11582.48   0.9654681    14088.96   14592.88   2.0573585    39700.95   19297.05   1.1120825   15486.96   13926.09    1.066565    10663.55   9998.03    0.8978073    5443.28   6062.86   0.8406248
                                                                   2.7214632     952.24      349.9                                      0.5968244     389.41     652.47
                                13.793402      79.45       5.76    0.7294598     144.63     198.27    1.1887814    415.17     349.24    0.8924077     362.38     406.07    1.9011215      378     198.83    1.2879982

                      433.67    1.2873347     547.04     424.94    1.2069457    2311.47    1915.14 0.48264834      657.84    1362.98    1.0328554    1688.14    1634.44 0.43939278      1022.01   2325.96   0.5519891

                      330.66    1.0842955     483.65     446.05    1.3369685     1630.5    1219.55    1.0510489    248.51     236.44    1.3845212      90.52      65.38                                     0.7451344
                      1809.5    0.7324655     447.91     611.51    1.3020425    1370.66     1052.7 0.98436147      589.79     599.16    0.4664989     365.25     782.96 0.78582424      158.32    201.47    0.8934829
                     5371.36 0.69084454       2848.2    4122.78     0.838415     4275.9    5099.98    0.8422269   3664.26    4350.68    1.9600152    13406.7     6840.1    0.5513959    1287.14   2334.33 0.87715614
                     8179.89    1.0516073    9269.57    8814.67    0.3764157    4445.74    11810.72   0.9523074   3253.92    3416.88    0.7736596    4616.62    5967.25    1.2169642    3252.69   2672.79 0.91396034
                     4671.86    0.9760715    3195.99    3274.34 0.63888556      3913.73    6125.87 0.75667155     3250.26    4295.47    1.0664433    5271.28    4942.86    0.8108571    2100.72   2590.74 0.79838204
                     21283.38   0.6817123    7059.39    10355.38 0.36023346     2977.92    8266.64    2.3086624   4620.28    2001.28    0.7802124    15600.05   19994.62   0.8479463    2462.47   2904.04 0.80142945
                     8300.08    1.4185266    4477.48    3156.43    1.3083719    20771.83   15876.09 0.83470327    11980.37   14352.85 0.93709815     7577.31    8085.93    1.2436615    5419.84   4357.97   1.0068802
                      260.22    1.0368758     419.24     404.33    1.1598655     1128.7     973.13    0.6567734    475.32     723.72    3.3194234     239.43      72.13    1.5811676    219.64    138.91    0.8179664
                                                                                                                                        0.23205431    251.28    1082.85    0.2683153     86.91    323.91
                                                                                                                                        0.2539705     107.78     424.38                                     15.107043

                     58576.19 0.71719575     13997.99   19517.67   0.9408543    22639.27   24062.46   1.390388    3133.17    2253.45    1.0732048    6619.13    6167.63    1.2529645    2374.33   1894.97   1.2181576

                                0.84113705    515.76     613.17 0.30523184        1260     4128.01    1.0859298    745.86     686.84    2.1043158     238.44     113.31    1.2676007    434.28     342.6    0.9554619
Molecular Medicine




                      329.03 0.69983995       223.06     318.73 0.15109706       103.71     686.38 0.73167175      426.25     582.57 0.69459754       481.37     693.02     1.128858    160.93    142.56    1.1005521

                     2537.42    1.1671954    1188.24    1018.03    1.1887639    6247.37    5255.35    0.6291298     473.2     752.15     1.027454     2483.5    2417.14 0.49987897      557.57    1115.41   0.97339624

                     9404.07    1.4026644    14221.74   10139.09   1.9705368    30284.61   15368.71   1.3024187   6775.13    5201.96    1.0380442     5645.3     5438.4    1.1247764    7822.01   6954.28 0.91680294

                     2611.34    1.1550288    2617.48    2266.16    2.7403157    6577.58     2400.3    0.8523867    1279.1    1500.61    1.1990005    3044.61    2539.29    1.3908728    1894.8    1362.31 0.91743064

                      2160.8    1.4933507     4170.6    2792.78    1.8717605      12076    6451.68    0.8266488    2166.2    2620.46    1.0317044    1477.38    1431.98    1.0768706    1560.31   1448.93    1.174901
                      934.33 0.92776227       1194.8    1287.83    1.2415972     2068.6    1666.08    1.2270739    558.11     454.83    0.7674385      727.9     948.48    1.3317525    820.04    615.76    1.1374234
                      354.02    1.1485887     690.52     601.19 0.77033794      4348.18    5644.51 0.98990333     1014.74    1025.09 0.96347284       623.55     647.19 0.44093862      116.69    264.64    0.9425345
                      327.99    0.9761792     392.18     401.75    2.4175391     258.58     106.96    1.1206481    190.88     170.33    1.0926837      71.09      65.06                                     1.5077099
                      377.04    1.8031224     388.05     215.21 0.58391243        569.7     975.66    0.6087356    245.01     402.49    0.4939869     481.82     975.37    0.6887513    443.79    644.34    0.7795096


                       91.81    1.5852666     459.87     290.09    0.6480623     990.79    1528.85    0.7901401    269.58     341.18    0.6046691     430.73     712.34    1.0939628    477.11    436.13    1.0448362
                     63874.96 0.67588747   24920.91   36871.39   1.1845417   28346.72   23930.54 0.95398676   22508.66   23594.31 0.78063905   59441.12   76144.18   0.7492775   29804.49   39777.64   1.0080621




                                                                                                                                                                                                             UNCORRECTED PROOF
                      832.77   0.7436072    533.91       718                                      1.5478729    677.86     437.93 0.31004956     158.95     512.66    2.3525279    542.14     230.45    1.6692997
www.molmed.org
Molecular Medicine
                           9                                             10                                            11                                            12                                           13                                            14




                                                                                                                                                                                                                                                                                       UNCORRECTED PROOF
                                                     CFS                                           CFS                                           CFS                                           CFS                                           CFS
                          Cy5             Cy3                           Cy5             Cy3                           Cy5             Cy3                           Cy5             Cy3                           Cy5             Cy3                           Cy5             Cy3
                     Patient         Control        Ratio          Patient         Control        Ratio          Patient         Control        Ratio          Patient         Control        Ratio          Patient         Control        Ratio          Patient         Control
                           44030.71       40849.61       1.3840123       27446.35          19831       1.5464112       18010.85       11646.87       0.5672857       18588.55       32767.53       0.8616472       28061.65       32567.45 0.99644387            41969.49       42119.27
                               92.05          93.93      0.7137065          415.42         582.06      0.2734254          134.23         490.92      4.1676736           55.18          13.24       1.633621           971.4         594.63      0.7572187          519.24         685.72
                             6811.76        5815.56 0.81205314             3155.46        3885.78      1.3004653         1514.99        1164.96      1.3013359         3066.52        2356.44      1.1382636         3537.78        3108.05      1.2439032         1798.46        1445.82
                              667.71         706.31      1.1459131         1737.72        1516.45      1.2858428           528.7         411.17      1.2904783          144.34         111.85    0.42704868          2197.49        5145.76      1.0627776          1833.1        1724.82
www.molmed.org




                                617.2       998.31     0.73307323        1052.18          1435.3         1.1795458      252.93          214.43         1.289111       159.94          124.07         1.2355516     1154.66          934.53         1.6650226     1222.01          733.93
                                                        0.6054758         594.22          981.41                                                     2.495615           99.6          39.91       0.7229893         709.52         981.37       1.0427492         611.27         586.21
                           1650.97         1173.77      1.0605968        3216.44         3032.67      0.8834131         796.07          901.13      0.8553496         558.74         653.23       1.5320821         2569.7        1677.26       1.0914832        1861.23        1705.23
                           21887.5        19441.62      0.8189951       29066.21        35490.09      2.6548545       28801.19         10848.5      0.8557499       20966.07       24500.23       1.1098237       28588.99       25759.94      0.98296833       29203.93       29709.94
                           2934.23         2888.91      0.7653035        1656.53         2164.54      0.9562911        1631.27         1705.83     0.91423047        1399.44        1530.73       0.7993175        1232.02        1541.34       0.9866448          1349         1367.26
                            964.55         1361.99      0.6667399         698.17         1047.14     0.31534708         485.42         1539.32      0.9399799          466.7          496.5      0.92835027         926.54         998.05       1.1331297          326.5         288.14
                            133.34          121.47     0.66327685          410.9           619.5     0.60163885         118.21          196.48                                                   0.85825485         393.63         458.64       0.8454652         370.17         437.83
                          40767.72        35307.59      1.5676414       58671.11        37426.36      0.6732633       43154.63         64097.7         1.9065099    57209.58       30007.49       1.7389449       81618.72       46935.77       1.3242956       31116.38       23496.55

                               907.64      1437.48         0.7436419     1140.36         1533.48         1.0635546      334.69          314.69         0.6601245      131.51          199.22         1.2987822     1505.86         1159.44     0.89211416         629.11          705.19
                           9394.55         7394.58         1.2581652     3569.44         2837.02     0.24174246        1130.25         4675.43          0.990371     1665.18         1681.37         1.0790913     2400.87          2224.9         1.2814628     1735.28         1354.14
                            443.44          307.91         1.1340959     2243.65         1978.36     0.82025623         585.95          714.35         3.4892285      819.55          234.88         0.9565837      2642.4         2762.33         1.7554716      474.03          270.03
                           5354.38         5244.72         0.9617832     3784.53         3934.91     0.92857057        1604.83         1728.28         1.1632166     1507.11         1295.64         1.4081762    11395.37         8092.29         1.0037084     1740.35         1733.92

                               276.34       231.59         0.8113961       540.26         665.84         3.311713            531        160.34     0.49015534             49.54       101.07         1.1706644      866.76           740.4         0.9963844      694.45          696.97

                           2351.89          2249.4          0.939886       1863.7         1982.9     0.89013803         631.09          708.98     0.69680077         681.29          977.74         0.8026637     1221.59         1521.92         0.947269      1073.18         1132.92

                               193.93       158.47         1.0506535       955.79         909.71     0.87678856             277.6       316.61         1.2132292      278.06          229.19         1.0027509         991.5        988.78         0.6310543      277.91          440.39

                           1929.92         2074.97         0.5557386          1501       2700.91         0.4535372      991.65         2186.48         1.2281413      269.27          219.25         0.6843909     2350.65         3434.66         0.7832259     2383.09         3042.66

                           1566.23         1558.85         0.5815036       1111.8        1911.94         0.5019873      448.36          893.17         0.6924013      375.51          542.33         0.9641049     2415.96         2505.91     0.75833184         456.22          601.61
                               222.43       541.12      1.0593983        1537.42         1451.22         0.6661821      417.03            626          1.2024555          479.9        399.1         1.0275562      2421.2         2356.27      1.1397768        1006.97          883.48
                                96.48         0.57     0.91591865         438.78          479.06         1.6439364      165.38           100.6                                                       1.2886556     2554.18         1982.05     0.73713344         386.14          523.84
                                                       0.64778334         453.39          699.91         0.5536662       76.19          137.61                                                       0.9971672      640.66          642.48     0.86661863         360.99          416.55

                                520.1       473.53         0.7030222       539.45         767.33         0.8570794      404.97           472.5         1.7779107      311.81          175.38         0.9191593      523.93          570.01         1.0821234         381.6        352.64
                           1290.93         1319.39         0.7606169       1429.8        1879.79     0.92104816         917.76          996.43     0.86381626         432.15          500.28         1.1380662     5872.82         5160.35         1.1554126      967.45          837.32
Molecular Medicine




                           6278.42          7511.3         0.9936155     6759.03         6802.46         0.7896149     3655.23         4629.13     0.79844284        3168.82         3968.75         1.0646439    15915.86       14949.47          0.9258921     2997.27         3237.17
                           4757.16         3688.44          0.777442     2469.77         3176.79     0.86653477        2522.89         2911.47         0.7007303          1419       2025.03         1.3772025     3258.42         2365.97         1.146596       894.62          780.24

                           2802.64         2623.32         0.8435057     3020.67         3581.09         1.751493      1029.51          587.79     0.60834616        1189.11         1954.66         1.1223868     8802.88           7843          1.1971903     3006.54         2511.33
                           5696.66         5174.09         1.3115115     6106.45         4656.04         1.7308031      786.65           454.5      1.1734552        1260.42         1074.11         0.9131906     6872.07         7525.34       1.474993        1470.45          996.92
                           1337.02         1179.28         1.1810337     2945.51         2494.01         1.3042841      906.96          695.37     0.62045467         902.47         1454.53         0.9364049     3583.79         3827.18     0.57306856          681.9         1189.91

                           8606.82        10081.52         1.4405282     8533.66         5923.98         0.7395441     3119.02         4217.49     0.92500526        1728.03         1868.13     0.98779553       29682.99       30049.73          1.0071927    10565.21       10489.76
                               118.13       137.03     0.93312556          517.95         555.07                                                       0.4975777      116.06          233.25      0.4372661         230.19          526.43         1.3739581      568.75          413.95
                               432.07       309.12      0.8740421          755.05         863.86     0.69880897             256.4       366.91          2.047338      194.19           94.85     0.82484657         419.22          508.24          1.569839      201.74          128.51

                           2733.61         2590.83         1.1027939     7727.52         7007.22         3.935336      2669.26          678.28         1.701182       709.58          417.11         1.5159626    10335.15         6817.55         1.1002479     4089.61         3716.99

                               702.86        926.1         1.4097968     1793.05         1271.85         3.1771946      503.49          158.47         0.7471813      710.42           950.8     0.71168077         404.74          568.71     0.68949115         250.83          363.79


                           6727.19         5101.53     0.98885757        2515.07         2543.41         1.4982275      2886.5         1926.61         1.7336483     1607.56          927.27         1.7206311     5592.86         3250.47         1.2004681     1851.77         1542.54


                                                           0.8615586       294.61         341.95                                                                                                      1.111484     1096.09          986.15         0.8943214      199.38          222.94
                                            0.7568091     429.86     567.99     79.32863     168.97       2.13   0.65712786      75.09     114.27    0.7462029     250.56     335.78   0.45120767      88.36     195.83




                                                                                                                                                                                                                     UNCORRECTED PROOF
                       3001.7     2704.2     0.711526    2848.58    4003.48     1.032715    1597.61      1547     1.3745577    1919.46    1396.42    0.9146125    1957.17    2139.89    1.3055356    1609.66    1232.95
                      5167.82     5250.7    1.2564145    3707.78    2951.08   0.52095425    1828.19    3509.31    0.9601398    2910.76     3031.6    1.2426131    2623.79    2111.51    1.0995954    3633.25    3304.17
                     21699.14   20347.22    1.3815706   13261.42     9598.8     0.820953    5262.99    6410.83    0.7185948    4172.93    5807.07    0.7593399   35872.29   47241.41    1.7024075   15013.77    8819.14
                      1561.66     1017.3   0.58916306     606.29    1029.07   0.41186598      500.1    1214.23   0.43816683      54.21     123.72    1.1612562     692.19     596.07    0.9661594     834.81     864.05
                      3015.74    2951.18    0.9038126    1837.93    2033.53    1.1434294     973.23     851.15    0.9674005    1314.91    1359.22    0.9590193    1822.76    1900.65   0.86615777      1870     2158.96

                       115.14     353.02      0.58258      822.9    1412.51                                                                          1.6609293    1439.76     866.84   0.8006501      330.06     412.24
www.molmed.org



                       147.93     199.02    1.0948149    1390.82    1270.37   1.8079925       308.1     170.41    1.121537      304.43     271.44      0.95323      652.2      684.2    0.886656      784.46     884.74
                       331.43     310.31    0.7955553     631.48     793.76   0.4980927      280.74     563.63     9.588169     173.45      18.09   0.87788665     464.92     529.59    1.5375327     141.33      91.92
                      2350.99    3185.14    1.5499603    2008.64    1295.93   1.1483636      679.28     591.52   0.27274594     133.04     487.78    0.6285171     3403.2    5414.65   0.72310734    1916.69    2650.63

                                           0.48119143     296.77     616.74   0.2333813      131.34     562.77                                       1.0963331     464.33     423.53
                       196.29     290.02     0.679395     474.34     698.18   0.22226371     154.82     696.56   3.6653225      218.16      59.52    0.9276084     352.25     379.74    0.5182075     211.04     407.25
                     16064.63   10874.39    1.4323459   12612.35    8805.38    2.1302083   12171.84    5713.92   2.2119741     5079.29    2296.27    1.7402194   14025.35    8059.53    1.2627171    9448.71    7482.84
                       165.94     180.89    0.6305923     475.29     753.72   0.13775657       9.53      69.18                                       1.1369866     501.07      440.7         0.01       1.09     147.74
                     22309.09    21414.3   0.92857814   31891.35   34344.28    1.3471681   12098.93    8981.01   1.1671144    13328.89   11420.38    1.5734692    49666.3   31564.84    1.4361383    15584.8   10851.88
                     17127.66   16441.97    1.1677805    8394.31    7188.26     1.459886    2081.52    1425.81   0.6364433     3101.91    4873.82   0.66535807   11680.54   17555.27    1.2085857    4289.73    3549.38
                     19070.13   18927.84    1.3985054   11801.61    8438.73     1.046294   12564.87   12008.93   1.2259686     7953.41    6487.45    1.0778825   10593.85    9828.39     1.475016   10715.21    7264.47
                       321.82     388.17   0.74322957     793.13    1067.14    0.7276615      238.2     327.35                                      0.91031355     431.17     473.65   0.29700372     148.19     498.95
                      3145.99    2597.94     1.280185    5706.86    4457.84    1.3369585     4698.5    3514.32    1.1454537    5981.33     5221.8   0.91127247    2053.27    2253.19    0.9379729    4289.35      4573
                       565.53     526.47    0.8843602      559.8       633     0.6534925     345.41     528.56     1.965292     231.59     117.84    0.6099978      221.6     363.28    0.7811826     423.44     542.05
                        302.8     118.84   0.98050797    1011.59     1031.7    2.3736238     319.11     134.44    1.7331716     214.22      123.6    1.1350262    1172.38    1032.91     2.716236     129.32      47.61
                     11874.09    14025.5    1.2055233      7098      5887.9     1.552052   11101.16    7152.57   0.75115967    5060.42    6736.81    0.7626367    9092.59   11922.57    1.1903547   12727.38   10692.09
                      4144.45    4994.66    0.5623201    2848.05    5064.82    2.2725868    1574.63     692.88   0.35685596    1384.28     3879.1    1.2744143    1613.88    1266.37    0.9727134    1239.84    1274.62

                      2993.91     3739.9    1.0361004    4411.84    4258.12   0.7159921     2018.31     2818.9   0.8496931     2678.36    3152.15    1.2389256    5448.46    4397.73   1.2768112     4609.11    3609.86
                      2482.06    2709.39   0.89978576    3593.87    3994.14   0.8065233     2399.06    2974.57   1.1053528     2082.96    1884.43   0.83811074    3081.75    3677.02    1.5123736    1865.18    1233.28
                       5954.2    4836.18    1.1832552    5164.01    4364.24    1.079699     5185.46    4802.69   1.0747435     4079.49    3795.78   0.77574253   10333.31   13320.54   0.96575797    3741.52    3874.18

                     14160.61   12863.73   0.67613816   14010.36   20721.15    1.118187     7995.45    7150.37   0.7641715     6628.66    8674.31     1.796218   10313.65    5741.87    0.976928     5153.93    5275.65
                       723.63     766.44   0.72328913     803.01    1110.22   0.19992433      570.7    2854.58    1.7512498     907.34     518.11    1.3858587    1466.28    1058.03    0.9873515     654.93     663.32
                     10742.85   11731.97   0.93501174    9475.55   10134.15     1.544167    8758.16    5671.77    0.3479624    2859.91    8219.02    1.9405626   17302.25     8916.1     1.426872    9475.13    6640.49
                      3529.41    3635.88    1.0526676    2576.72     2447.8   0.83123803    1682.06    2023.56      0.95933    1077.27    1122.94   0.85704386    8940.99   10432.36     1.120735   11381.95   10155.79
                       364.31     484.41   0.55508715     584.64    1053.24    0.7320387     327.58     447.49    0.3457921      13.97       40.4     1.341648     716.44       534     0.5885656     196.01     333.03
                       489.02     389.59    0.6688381    1102.72    1648.71   0.91961086     366.75     398.81    1.1996331     326.96     272.55    1.4555893    1811.51    1244.52    1.2920699     871.54     674.53
                     18867.31    9763.82    2.1001792   17475.99    8321.19    1.4166423    6293.15     4442.3    1.1224811    6722.36    5988.84    0.9886529    4944.52    5001.27    1.2223284    8788.97    7190.35
Molecular Medicine




                      5418.44    4043.89    1.0018114    2118.23     2114.4    1.3971764     778.87     557.46   0.88276726     686.89     778.11    0.8916743    4225.35    4738.67   0.64434755    1220.71    1894.49
                     11094.87   11727.69    1.1290998    4137.27    3664.22    0.9818956    1897.15    1932.13    1.0206556    1591.59    1559.38    0.8606101    6684.72    7767.42    1.2872522    3327.65    2585.08
                       962.03      64.19    1.2981138    1023.42     788.39   0.86320615     226.16       262                                       0.39630252    1055.96    2664.53   0.75139135     498.18     663.01

                     28815.09   26319.05    1.0159664   21502.41   21164.49   1.0976363    12525.82   11411.63   2.0235903    18677.01    9229.64    1.1936741   41635.35     34880    1.9438378    12482.49    6421.57
                       511.58     617.55    0.7336649     950.03    1294.91   0.25784576     346.06    1342.12   0.80883795      66.26      81.92   0.88011783     911.45     1035.6   0.44518992     307.23     690.11

                       408.68     152.14    1.1403726    1779.54    1560.49    2.610531      400.09     153.26                                       1.1754057     935.67     796.04   1.2918437      681.37     527.44
                     16697.34   17992.98    1.6164203   13558.21     8387.8   0.9109417     4401.16    4831.44    0.831754     6861.58    8249.53    0.7069769   20034.17    28337.8   0.73569345    5327.48    7241.44
                       782.84     899.89    1.0056323    3172.78    3155.01                                      0.4678633      508.02    1085.83   0.64874077    2078.28    3203.56    0.7679309    1036.63     1349.9
                      9432.51     8846.1      0.71503    4734.85    6621.89   1.4065999     6107.47    4342.01   0.5474535     2020.64    3690.98   0.77238524     3539.1    4582.04   0.84606737    4073.95    4815.16
                      10779.9   10633.81   0.69742876    5760.42    8259.51   0.7738497     4748.11     6135.7   1.3809384     4693.34    3398.66    1.3767607    3374.11    2450.76    1.4076707    3557.17    2526.99

                      1226.83    1243.23    1.0528097     6311.5    5994.91   1.3589239     8380.09    6166.71   0.8333113     5803.33    6964.18    0.5708168   11115.43   19472.85   1.0110844    11414.76   11289.62
                      2951.57    2270.03    1.2664176    4502.52    3555.32   0.8105961     2626.68    3240.43   1.0914383     2077.52    1903.47    1.0800632    3697.64    3423.54   1.0496861     2420.24    2305.68

                       108.78     375.66     1.222631     927.17     758.34   0.9080576      280.39     308.78    1.501022       308.4     205.46    0.7743622     359.97     464.86   1.1554943       544.7      471.4
                       140.49      33.67   1.1089382      313.02     282.27                                       1.5521319      43.32      27.91   0.6980746       306.72     439.38   0.5262638      122.53     232.83




                                                                                                                                                                                                                      UNCORRECTED PROOF
                      2538.86    3374.16     0.63089     4318.48    6845.06   0.7109058      885.81    1246.03     1.404333     954.82     679.91   1.1236315      1358.83    1209.32   1.3928399      950.85     682.67
                      1020.74     767.72   0.95387644     1564.3    1639.94   0.85046005     701.57     824.93     0.608962     278.32     457.04     1.033026     2378.47    2302.43   1.0988184      493.82     449.41
                      1252.86    1346.24    1.3218163    2362.35     1787.2    0.8662262     761.69     879.32    0.9484235    1106.08    1166.23   0.64947605      2638.1    4061.89    0.950714     1802.82    1896.28
                      3150.32    2996.66    0.9768848    3489.54    3572.11   0.27011326    1908.18    7064.37    1.0098953    1970.75    1951.44    0.9233014      971.23    1051.91   0.9630495      972.94    1010.27
                     23714.44   23987.58     1.623942   21077.94   12979.49   0.95954114   15069.91   15705.33    0.9012636    7430.63    8244.68   0.75014067    22843.03   30451.66   1.0232241    27438.88    26816.1

                                           1.0092505       668.8     662.67   7.8239512      141.77      18.12                                      1.1338363      5600.21    4939.17   1.2078996      203.06     168.11
www.molmed.org




                     12215.79   12163.88   0.96742094   30793.57   31830.58   1.4571376     5800.53    3980.77   0.70326245    8234.81   11709.44   0.7222207      28579.2   39571.28   0.45165285    6636.37   14693.52

                      11560.3   14837.77   1.1797118    12416.29   10524.85   0.47801507    4519.69    9455.12     0.724684    6954.56    9596.68   0.8499991      7478.25    8797.95   0.98842895    5215.07    5276.12
                     29365.45   30002.89   1.9219424    50220.37   26130.01   1.1718357    18681.65   15942.21    1.0129254   17649.78   17424.56   0.91749495     7308.04    7965.21   1.1286205    13405.45   11877.73

                      1916.52    1763.16   1.1217098     2768.75    2468.33    4.576619     4309.39     941.61    1.5286946    3908.49    2556.75   2.2834365      3361.15    1471.97   1.1708685     1885.11    1610.01
                      6311.39    6577.36   1.0249809    12099.89   11804.99   0.67688996     5781.1    8540.68   0.62072444    3086.85    4972.98   1.4610215     30317.85   20751.13    0.6501234    4747.37    7302.26
                     13453.79   13971.89    1.014366    11419.51   11257.78    1.2501471    6670.41     5335.7   0.95956105    4278.27    4458.57    1.612393     23568.88   14617.33   0.86590296     8665.1   10007.01

                     26183.73   33682.38   1.0146257    20975.62   20673.26   1.2905087     9949.01    7709.37    0.5637629    7469.43   13249.24   0.9263053     59923.96   64691.37   0.52601695   10867.31   20659.62

                      4678.84    4463.54   1.3675625    10735.53    7850.12   1.1571897    14162.37   12238.59    1.1540229   10306.89    8931.27   1.0958132      8819.63    8048.48   1.3641758     5156.23    3779.74
                      4701.82    3730.04   1.0359222     4271.77    4123.64   5.4002814     4987.97     923.65    1.1523857     3332.1    2891.48    1.149949      4640.32    4035.24   0.97393966     1787.9    1835.74

                     52604.26   63211.33   1.2476711    80928.25   64863.45   1.1534406    52131.54   45196.55   0.56371117   36242.24   64292.21   0.6516839     45567.01   69921.95   0.86569756   43185.96   49885.74
                     16455.78   18994.77   1.0273293    10234.08    9961.83   5.0781913     1758.73     346.33    0.8653157    1993.22    2303.46   0.9150549       11955    13064.79   0.71036863    1637.62    2305.31

                      4346.16    3327.05   1.3735521     3938.07    2867.07   1.1725471     1165.16      993.7    1.6081473      3065     1905.92   1.0262116      1301.77    1268.52    1.170578     1188.64    1015.43

                       385.77     363.37   0.7790369      495.67     636.26   0.48963043     270.56     552.58    1.6213944     169.76      104.7   0.87296283      328.88     376.74   0.7642446      223.19     292.04

                     29106.93   30692.21   3.3204353    78637.63   23682.93   1.0644586     9067.41    8518.33    1.0730971   26080.51   24303.96   0.5060279     41798.45   82601.08   0.9847315    17206.38   17473.17
                     24933.11    25041.9   1.7826116    32655.52   18318.92   0.71230245    7489.44   10514.41    1.7036035   13872.58    8143.08   0.92973125    36908.46   39697.99   1.4877813     11020.1    7407.07
                       1982.5    2689.61   1.0338572     3896.98    3769.36    1.3828089    1943.22    1405.27    1.1603559    2499.07    2153.71    0.9671336     1154.39    1193.62   0.9533885     1212.51    1271.79

                        898.6    1185.37   0.52860105     932.78    1764.62   0.4498889      496.07    1102.65    0.5763438     485.95     843.16   1.3381335       691.36     516.66   0.79269385     601.29     758.54


                      1389.25    1533.53   0.5463854     1003.18    1836.03    0.648707      372.52     574.25    0.6162102     347.37     563.72   0.4240495       1107.1    2610.78   0.49958742     351.16      702.9

                      8043.68   10338.28   0.78424263    8510.53   10851.91   1.2985157     4504.46    3468.93    0.8690178    6178.76    7110.05   1.0396119      4729.32    4549.12    1.020892     6797.64    6658.53
                     33157.22   25736.34    1.0859721     8601.8    7920.83    4.093093     3669.99     896.63    0.6585725    4574.84     6946.6   1.1440094      5233.98    4575.12   1.1699806     8071.17    6898.55
Molecular Medicine




                       95276      64385     1.5679532   94048.44   59981.66    5.679591    77941.31   13723.05    1.0464473   66926.28   63955.71   1.7481316    113089.03   64691.37   1.2375364    79963.09   64614.74

                       291.89       165    0.84886265     377.26     444.43   1.1534051       211.2     183.11                                      1.2771424       619.81     485.31   0.27543002      61.33     222.67

                      2402.99    2475.98   1.5152295     4819.49     3180.7   1.2027445     7358.27     6117.9    0.6893471    3074.75    4460.38    0.662448      3888.04     5869.2   1.0399402     2847.71    2738.34

                      8406.73    9625.96   0.9103178     7594.79    8343.01   0.9337924     6897.56    7386.61     0.915984    4062.38    4434.99   1.8326526      9819.48    5358.07   1.2033105     7166.52    5955.67

                       426.05     404.21   0.78027767     552.46     708.03   0.48846617     258.34     528.88    0.8212661     146.21     178.03   2.0437171        933.1     456.57   0.6969316      571.01     819.32

                      9646.45    7310.03   1.2855748    11110.22    8642.22   0.7081831    10485.55   14806.27    0.9979043     4375.9    4385.09   0.86650586    12378.98   14286.09   1.0424846    10174.63    9759.98

                        43.69       92.9   0.9819967      843.27     858.73    1.454662      204.38      140.5    4.4829793     133.01      29.67   1.3278066      2123.88    1599.54   0.9717418      914.03     940.61
                      2385.47    2139.14   1.1693845      6275.7    5366.67    2.006314     4416.78    2201.44   0.75234586    3864.53    5136.64   1.2440255     17400.52   13987.27   1.1140893     8995.78    8074.56
                      5563.84    5199.69   0.8161369     2913.78    3570.21   1.0247456     1204.24    1175.16   0.47143462     924.95    1961.99   0.8589063      5884.29    6850.91   0.7793961     1737.04     2228.7

                      1706.92     1845.1   0.6054187     1245.54    2057.32   0.7405796     1469.11    1983.73   0.45697945     306.03     669.68   1.2448386      3271.61    2628.14   0.8318583     1971.92     2370.5
                       756.09     660.09   0.7335947     1265.04    1724.44   0.67406964     497.76     738.44    1.3581666      425.5     313.29   1.2759161      1963.15    1538.62   0.73176384     856.31     1170.2
                      1787.25    2198.34   1.5145168     4131.42    2727.88   3.1845329      1450.3     455.42   1.4018736     2166.82    1545.66    1.0973581    6102.65    5561.22   0.99558544     2178.52    2188.18




                                                                                                                                                                                                                      UNCORRECTED PROOF
                      1037.28    1225.21    0.9929979    2582.42    2600.63    0.8696149    1956.59    2249.95    1.1735224    1464.11    1247.62    1.0882427    2243.63     2061.7     1.1640728     473.44     406.71
                     13565.78   14696.87    1.2763071    6515.51    5104.97    1.5750234      2421     1537.12    0.6406364    2095.56    3271.06    0.6107254    2973.28    4868.44     0.6846491    2412.19    3523.25
                       505.03     775.88   0.89680266    1393.73    1554.11    0.8601382      758.1     881.37    1.0195194     771.45     756.68   0.86674833    1096.74    1265.35    0.89055526    1080.76    1213.58
                      5617.76    5445.79    0.7705123    3554.35    4612.97    1.0127392    3817.48    3769.46   0.53501475      1165     2177.51   0.67275834    1661.37    2469.49     1.1896995    2032.34    1708.28
                      9400.96    7361.71   0.79332227    4749.89    5987.34   0.61819756    3560.96    5760.23    1.0477059    2373.85    2265.76    1.7016962   44036.97   25878.28     1.0240126      4589     4481.39
                      2730.28    3513.89    0.7826836      4035     5155.34    2.8236961    6994.38    2477.03    0.6809609     3993.4    5864.36    1.1286887    7483.68    6630.42     1.1907802    3101.53    2604.62
www.molmed.org



                      1620.14    1433.48     0.883922     276.04     312.29    0.9271712      81.35      87.74                                       1.9317168     658.02     340.64    0.46317244     104.01     224.56
                      6226.61    9331.19    1.0537295     7010.8    6653.32     1.559241    1011.62     648.79   0.88671654    2902.64    3273.47    1.0390855    3349.44    3223.45     1.1880482    1397.81    1176.56
                       556.76     643.41    0.8026948     605.28     754.06   0.65195364     253.46     388.77    1.2984823     199.33     153.51    1.0162193     728.68     717.05      1.940524     274.72     141.57
                      1460.49    1722.05    0.9154434     788.92     861.79    1.0950785     477.06     435.64    4.0584106     231.37      57.01    0.7681597     246.61     321.04      0.664029     294.55     443.58
                      7563.94      6598     0.8461997    9993.72   11810.12     0.561729     746.33    1328.63    1.4761537     786.17     532.58    1.7191334   38491.17   22389.87     1.4803715    5014.24    3387.15
                     14658.63   20165.52    0.8737154     7512.1    8597.88    0.9008968    2447.25    2716.46   0.75673443    5224.51    6904.02   0.81421185     5101.2     6265.2     0.9390744    3434.89    3657.74
                        10.25      69.02    1.0409021     304.11     292.16   0.32745132     167.01     510.03    2.7084708      73.86      27.27    1.1123053     513.34     461.51   0.120506205      34.09     282.89
                       332.59     188.58   0.81988853     688.28     839.48    1.6179752     165.26     102.14                                       0.6444144     857.78     1331.1     0.9581244     489.18     510.56
                       3399.1    4841.96   0.71095014    3375.52     4747.9     0.988468    2450.58    2479.17   0.6494402     1792.02    2759.33   0.94314724   15190.99    16106.7     1.2806237    4059.91    3170.26

                     12066.71   11583.11   1.3347163    20223.46   15151.88    1.591515     6723.61    4224.66   0.8805143    11037.01   12534.73    0.8822752    8146.85    9233.91    0.9960078     9004.27    9040.36
                     20005.68   20324.97    1.1606033   13149.67   11330.03    1.2788806    3930.55    3073.43   0.70962507    5468.25    7705.83   0.58631516   12812.78   21853.06   0.83976126     4271.11     5086.1
                       249.45     388.15     0.736761     329.73     447.54    1.3282299     170.04     128.02                                      0.80933416      333.3     411.82    0.5132455      241.21     469.97
                      1661.21    2871.69    0.6234918     796.86    1278.06   0.24421027      288.3    1180.54    0.7151981     230.68     322.54    1.1558859    1016.96     879.81    0.9144878      854.79     934.72
                       382.93      292.6    0.5030157    1020.81    2029.38    0.7622097     415.45     545.06    0.6263859     373.99     597.06   0.45223233     521.46    1153.08   0.82455397      543.01     658.55
                      9519.76    9500.33    1.0692718    8946.03    8366.47   0.91929144    2994.84    3257.77   0.68430144    3121.66    4561.82    1.0570661   14463.18   13682.38    0.7515428     4297.63    5718.41
                       115.65     173.57   0.73675835    1000.54    1358.03    0.5880393     160.57     273.06    0.7886717      106.1     134.53     1.167334    1268.53    1086.69   0.92435557      460.44     498.12
                       153.05     284.91    1.2220981    1444.74    1182.18    0.5728033      323.8     565.29   0.88906115     269.51     303.14    1.4468071     674.27     466.04    1.4380149       71.57      49.77

                     52088.14   41388.96   0.75753987   10217.85    13488.2   1.9908104    10353.09    5200.44    1.241787    12648.42   10185.66    1.9430248   31467.83   16195.28    1.2524517     9066.31    7238.85
                       236.95     172.79     1.37801     2146.54    1557.71    4.720919      2676.1     566.86   2.3670144      592.44     250.29     1.891359   23681.27   12520.77    0.9825016     1698.48    1728.73

                     12106.26    9731.13   1.4381115    13236.22    9203.89    2.927555     5847.85    1997.52   1.4772615      4648.1    3146.43    2.0995564   36100.34   17194.27    1.1003768    10378.38    9431.66
                     27131.99   29704.41   1.2072021    14210.12   11771.12   1.6962571     64730.8   38160.96   1.2793832    23950.73   18720.53    1.5631843   38432.81   24586.23    1.3684045     34930.4   25526.37

                     25949.76   20076.23   1.1374755       8208     7215.98   1.8027372      554.54     307.61   0.5575186     1803.79    3235.39   0.24959481     971.71    3893.15     0.716063      1260.5    1760.32

                      5293.52    8026.09   1.2653903     4895.39    3868.68   2.4521832      1173.1     478.39   0.7122137      973.24     1366.5   0.67170393    2846.95     4238.4    0.7105935      2217.4    3120.49

                     61535.57     64385    2.0147386    82934.82   41164.06   1.1656505    15565.91   13353.84   0.8234686    24679.93    29970.7    0.6067208   33525.83   55257.42    0.7198053    20329.75    28243.4
                     45970.83   55127.58   0.9047573    58685.68   64863.45   0.48825958   37721.52    77257.1   1.0142076    65033.87   64122.84   0.87110275    28235.7   32413.74    1.3977324    52886.56    37837.4
Molecular Medicine




                      5596.43    2924.77   1.8199425     6152.17    3380.42   1.6370882     1737.72    1061.47   1.1435671     1576.27    1378.38    1.0803524   12187.79   11281.31    0.7383759     2011.55    2724.29
                     64288.26   62723.77   1.7281033    43988.28   25454.66    1.061704     6333.67    5965.57    0.649814    20505.18   31555.46    0.5197945   38922.19   74879.95   0.88147694    23639.37   26817.91

                       4614.1    3141.15   3.3524172    14462.26    4313.98   1.0896845     1400.31    1285.06   3.7859385     1409.24     372.23    1.4134958    9234.34    6532.98    1.1502234      4954.3    4307.25
                     30595.03   30290.71   1.7846076     32307.2   18103.25   0.93726104   10999.32    11735.6   0.96997875   14512.24    14961.4    0.8289711    17597.2   21227.76   0.71653426     4204.63    5868.01
                     78238.85     64385     2.386348    125279.5   52498.42     3.623145   24228.73    6687.21    1.8804823   60569.92   32209.78    1.4585009   69742.93   47818.23    0.7885295    17984.56   22807.72
                     17597.77   12248.99   1.9922023    28064.99   14087.42    1.7792686   20604.09   11580.09    2.1542923    9684.88    4495.62    1.5291569   45862.83   29992.23    0.9195013     9334.63   10151.84

                       2985.3    3649.03   0.93314207    1870.11     2004.1   1.2966113      974.17     751.32   0.67726517     403.86     596.31    0.5724913     1006.6    1758.28   0.99257755      401.18     404.18
                      4767.65    8965.84   1.6712757    16984.44   10162.56   0.72807616    2799.14    3844.57   0.8383524     7057.15    8417.88   0.55433255   10901.36   19665.74    0.8299654     9243.01   11136.62
                     19876.18   28147.34   1.0090631    16081.52   15937.08    1.3947282   12347.71    8853.13   1.3334774    17942.54   13455.45      1.57204   39485.56    25117.4     1.223742    13867.15   11331.76
                      8194.45    5294.54   1.0900631     5297.87    4860.15    3.0984347    5274.93    1702.45   2.6345196    11568.57    4391.15    1.0899334    9218.21    8457.59     1.603828     6893.75    4298.31
                      1432.31    1941.38   1.1166748     1100.55     985.56    0.6280537     358.38     570.62   1.3279574      341.71     257.32    1.0228648     369.96     361.69   0.88390154      528.14     597.51

                      5086.84    5168.38   1.0297649     8681.36    8430.43   0.8625118     2261.92    2622.48   1.0405737      610.13     586.34   0.94283795     8287.8    8790.27   0.94595623     3096.72    3273.64
                      3191.28    3287.52   1.0236479     5072.39    4955.21   0.7724591     2064.93    2673.19   1.1414552     2922.97    2560.74    1.1291811    7553.59    6689.44    1.2822751     3695.85    2882.26
                     11016.49   12914.22   1.1462061    17356.14   15142.25   1.0774137     8723.28     8096.5   0.8229454    10179.72   12369.86    0.8827189   46674.93   52876.32    1.1244358     18731.1   16658.22
                                            0.9642982      693.07     718.73         9.2      166.98      18.15    5.7109575      90.69      15.88   1.0538621     5046.44     4788.52   1.0501397     2490.28    2371.38




                                                                                                                                                                                                                       UNCORRECTED PROOF
                       646.85      609.56   0.6763105      547.94     810.19   0.54898363     358.92     653.79           1       168.5      168.5   1.4200032     1244.86      876.66   1.0403695      691.44     664.61

                       854.53      572.34   1.1019732     3932.81    3568.88   1.1009208     1941.76    1763.76    1.6749938    1822.41    1088.01   1.1459407     7592.35     6625.43   0.9843443     2186.78    2221.56
                       3709.17    3169.35   0.92810977    5097.81    5492.68     1.269705     977.33     769.73   0.89314955    1242.38    1391.01   0.89113593     4267.73    4789.09   1.2457849     1878.98    1508.27
                       1594.87    1837.86    0.7948843    1188.36    1495.01   0.83412504     646.18     774.68   0.49869555     458.77     919.94    1.8249654     1769.45     969.58   0.9768203     1158.46    1185.95
                     189425.02     64385     2.6303797   170615.5   64863.45    1.7284598   41119.49   23789.67     2.727401   82000.16   30065.31    1.9629126   126983.51   64691.37   0.9632341    62239.12   64614.74
www.molmed.org



                      23194.92   19678.25    1.6342072   32100.34   19642.76    1.3536233   23055.29   17032.28    1.1027058    31910.3   28938.18    1.1456187     1602.48    1398.79   0.8279775     1697.95    2050.72
                      57046.27     64385     1.0897336    46989.4   43120.08    1.3175852   31993.25   24281.73     1.204085   35890.68   29807.43    0.9768499    63193.76   64691.37   0.8333475    41816.52   50178.97
                      11439.45    9562.01     0.813748    3725.42     4578.1    1.0789204     2338.7    2167.63    1.2015411    4151.06    3454.78    1.0430559     4758.39    4561.97   1.4097077     2388.51    1694.33

                      2668.54      996.36   1.0128695     1939.24     1914.6   0.90901786    2352.02    2587.43    0.5282612     762.17    1442.79   0.69838834    1377.11     1971.84   0.8916371      406.64     456.06
                     50279.52    50729.89   1.0467767    23372.86   22328.41   0.6556033      9417.4   14364.48    1.3881462    9260.06    6670.81   1.2953861     18303.3    14129.61   1.3447455     7968.02     5925.3

                       271.95      184.41   2.1387277      622.99     291.29   14.239258      291.62      20.48    1.6259058     271.51     166.99   0.73234695     604.34      825.21   0.7053975      198.52     281.43
                     16495.09    15098.85    1.6067687   16673.39   10376.97   1.7315625    18456.81   10659.05   0.97295016   13337.27   13708.07    1.0867455   22663.59    20854.55    0.9829695   21451.46   21823.12
                      1358.48     1984.06     1.303143      3433      2634.4   1.6761482      634.64     378.63   0.48568374     703.95     1449.4    0.9019707    1431.68     1587.28     0.915246    1690.56    1847.11
                      6701.15     7878.52    0.9222307     7916.3    8583.86   1.5461075     1741.52    1126.39    0.8202702    2124.27    2589.72    1.5234737     10612      6965.66    1.4166981    4545.83    3208.75
                       3666.1     1040.06    2.5446043    4503.67    1769.89   2.7042809     1389.73      513.9    1.5542235     558.79     359.53    1.5599259   13366.85      8568.9   0.40088135     742.32    1851.72
                     58766.77    73839.57   0.62836957   45031.95   71664.75     2.33648    11989.25    5131.33    0.9266489   17721.65   19124.45    0.8662426    9164.05    10579.08           1    11429.06   11429.06
                       270.11      268.35      1.18916    1704.97    1433.76   1.5153992      279.97     184.75                                      0.83004946     633.61      763.34    0.7641712     432.07     565.41

                     28892.73    37077.98   2.0183005    21396.75   10601.37   0.61359674    7580.81   12354.71    0.6568205    7675.92   11686.48   0.59033525    7101.52    12029.64   1.0391774     4037.89    3885.66
                                             0.8025041     384.56      479.2    0.3702216     135.49     365.97   0.20118593       28.5     141.66   0.94064534     3629.8     3858.84   0.90785104     407.38     448.73
                      2272.26     1756.71   0.98569334    1414.47      1435     1.2041066     975.82     810.41      2.20476    1179.26     534.87    1.1284403     588.38      521.41    1.2113962    1221.79    1008.58
                      1225.07     1035.22   0.77905005      995.4    1277.71   0.84109145     544.06     646.85                                       1.0482225    1137.29     1084.97    0.6919932     507.75     733.75

                      7491.44     6108.23   1.6259693     9125.59     5612.4   1.1301886      3120.1    2760.69    1.2091073     2413.1    1995.77   1.1246791     8483.14     7542.72   0.98303825    3332.48    3389.98
                       2558.8     3179.93   0.61602485    2310.66    3750.92    1.3287601    5486.65    4129.15   0.45365676    1021.39    2251.46    1.1887281    6449.48     5425.53    0.8927878    3143.14    3520.59
                       5257.2     4147.03   0.99869967    3410.18    3414.62   0.49787843       846     1699.21    1.3845528     510.36     368.61    0.9605639    2234.31     2326.04    1.3098377     880.08      671.9
                       839.63      898.47    1.1463671    1845.33    1609.72   0.71345234     891.53     1249.6    1.0273926     843.14     820.66   0.88483953     1185.8     1340.13   0.85200757     879.11    1031.81
                      1778.71     1493.26    0.9439071    1381.88      1464     1.2836598     219.57     171.05     1.785121     292.26     163.72    1.0307549     510.77      495.53    0.3978229     115.85     291.21
                     92948.22    60864.21    2.0350637   66838.72   32843.55    0.6669355   42749.03    64097.7    0.6584548    42311.2   64258.32    1.1026309   26721.31    24234.14   0.90922457   18381.84   20217.05

                       659.41      857.76   0.76646554     752.01     981.14   0.7761833      190.39     245.29    3.3677464     105.04      31.19   0.9332691      213.14      228.38

                      2387.95     1778.08   1.0736759     2275.57    2119.42   1.0296624     1811.31    1759.13    2.0594742    3766.49    1828.86   0.95710063    1710.31     1786.97   0.9987227     1211.95     1213.5
                       230.71       344.4    1.2795986    2716.14    2122.65      1.34449     596.12     443.38    0.7550673     509.61     674.92    1.4078945     2413.3     1714.12   0.97695255    2761.21    2826.35
Molecular Medicine




                      5326.09     4106.24    1.1192124   11323.15   10117.07    0.9695139    1983.16    2045.52   0.66238457    1045.17    1577.89   0.65555346   15026.97    22922.57    0.7681609    2434.54    3169.31
                     10453.61    29002.56    0.8462118   17311.37   20457.49    1.7268066    33141.2   19192.19   0.81959975   52693.88   64292.21    1.9728163   36637.47    18571.15    1.0287265   29845.05   29011.65
                     83051.09      64385     1.0002527     33011    33002.66    0.7420232   19097.57   25737.16    1.4526482   22397.48   15418.38    0.8538908   54161.72    63429.33    1.3235472   18697.38   14126.72
                      4036.07     3516.74   0.87673813    1931.91    2203.52   0.43507358     979.69    2251.78   0.90411973     994.83    1100.33    0.9661253    8335.42     8627.68    1.1790438     1840.9    1561.35
                      4535.97     4273.97   0.78036505    2086.15     2673.3     1.116224    1237.58    1108.72    1.4027872     637.16     454.21   0.89368093     1571.1     1758.01    1.2852962    1839.67    1431.32
                      1795.02     1979.44   0.78331053     1065.6    1360.38    0.3297591     438.23    1328.94    1.9285883     328.94     170.56   0.74820924    1023.67     1368.16    1.1408107    1286.96    1128.11
                      2624.43     2441.11    0.7058845    1314.47    1862.16    0.5777435     418.76     724.82    0.5123869     243.02     474.29    0.7137852     916.65     1284.21     0.741487    1154.74    1557.33
                       603.84      477.16    0.5668488    1572.62    2774.32    1.1052288     304.17     275.21   0.68278676     512.37     750.41    0.9263514     779.71       841.7    1.1311806    1054.43     932.15
                     26298.54    18984.67   0.99533015   14964.62   15034.83    1.7169635   12428.55    7238.68    1.1223798    8885.33    7916.51   0.74828476   21696.92    28995.54   0.97297347   13404.48   13776.82

                       933.51      969.89   2.3723986      256.48     108.11                                       1.8543533      68.37      36.87   0.9905899      383.18      386.82   0.43503073     110.55     254.12

                     23851.84    12324.06   2.5856369    26447.21   10228.51    3.418819    17131.77    5011.02    1.2909265   13014.85   10081.79   1.4702115    30990.88     21079.2   0.9952057     7591.19    7627.76
                     12191.47    10363.71   1.2482443     9501.96    7612.26   0.87226015      5007     5740.26   0.96211016    3223.55     3350.5   1.3538005    14671.34    10837.15   1.5060595     5225.59    3469.71

                        661.6      619.02   0.6125463     1349.17    2202.56   0.9480953      696.12     734.23    0.6415647     439.69     685.34   0.8586608     1418.19     1651.63   0.75297886     195.27     259.33
                      1209.12     1147.63   1.2918226     1898.85     1469.9   1.7278914     1406.59     814.05   0.88509494     553.68     625.56   1.6099641    10077.28     6259.32   0.6647581     2070.07    3114.02
                     29367.02    20985.71   3.2295954     40399.3   12509.09   1.0559788    16879.79   15984.97    1.8000357   22804.76   12669.06   1.3890735    64920.06    46736.23   1.0671268    10705.96   10032.51
                      6412.82    5136.78   1.1259942     4501.86    3998.12   1.4688349     3319.42     2259.9   1.4091095     1416.62    1005.33   1.6468718    17936.74    10891.4   0.92733085    2312.93    2494.18




                                                                                                                                                                                                                     UNCORRECTED PROOF
                     24205.14   21494.67     1.48132    29685.92   20040.18   0.37316188   15919.16    42660.2   1.4292804    22328.02   15621.86   1.0575055     7734.69    7314.09   1.4252682    13221.43    9276.45
                        2861     2417.72   0.6437789     2057.73    3196.33   1.5459309      693.35      448.5   0.5848837      531.94     909.48   0.7661192     2256.06    2944.79   0.79314935    1054.96    1330.09

                       564.91     487.92   1.0424824      705.01     676.28   2.4634557      338.06     137.23   0.9577185      279.74     292.09   1.0104706      576.14     570.17   0.9704046      483.31     498.05
                      1606.52    1561.53    0.9481068    2293.84    2419.39    0.5883494    1146.14    1948.06    0.8414536    1266.96    1505.68   1.2292765    10883.56    8853.63   1.0801032     3403.34    3150.94
                      2052.95    2212.23    0.8456854    1541.71    1823.03     1.304155    1670.14    1280.63     0.839173     1878.9    2238.99   1.1832324     1751.61    1480.36    0.961821      5395.2    5609.36
www.molmed.org



                       170.05     159.97    0.7467883     530.16     709.92   0.41813454     165.69     396.26   10.3600855     143.28      13.83   0.8386038      715.48     853.18   0.9223306      156.87     170.08
                     35454.65   31893.52    1.6203601    29651.1   18299.08     2.713176   46205.17   17029.92    1.7263076   26234.18    15196.7   1.7574705    11750.57    6686.07   1.3214409     9375.57    7094.96
                       867.67     527.74   0.96048385    1030.58    1072.98    1.9125515     529.05     276.62    1.1597058     274.34     236.56    1.642057     8026.26    4887.93   1.1897056      4216.4    3544.07
                      8418.67    6305.48    0.8699506    4649.86    5344.97    1.6091721    6521.91    4052.96     1.408578    6913.09    4907.85   1.1561543     1698.09    1468.74   1.1357194     1047.44     922.27
                      2727.01    2394.16   0.72336257     2296.3    3174.48    0.9322458    3494.43     3748.4    0.5328219    1243.18     2333.2   1.3428415      7609.4    5666.64   0.9481538     2712.81    2861.15

                      2102.67    2525.27   1.1791183    11064.61     9383.8   0.54495883    2333.59    4282.14    1.012544     2725.07    2691.31   0.7431942     5970.57    8033.66   1.0900403     3414.05    3132.04
                      2310.01    2088.88   0.59843785    1253.47    2094.57   1.0853319     1960.37    1806.24    0.9158246     691.53     755.09    1.0361289    2384.92    2301.76   0.96927816    1656.07    1708.56
                      59865.6   50499.47    1.4094164    47071.8   33398.08   0.9188206    38661.62   42077.44     1.318478   55804.66   42325.06    0.6341606   34481.42   54373.33     1.075569   26710.67   24833.99
                       125.76     104.28   0.74617714     421.12     564.37                                        3.557395      32.23       9.06    0.7571169      187.5     247.65   0.51807505      66.64     128.63
                      5778.03    6676.51    0.7103088    3473.41      4890    1.5650998      1318.8     842.63   0.42912745     1380.4    3216.76    0.8253862    5318.12    6443.19     0.813086     2690.9    3309.49
                      4853.97    6513.93    0.8495897    3589.78    4225.31   0.8612596      1060.4    1231.22   0.29919824    1085.56    3628.23    0.9750088    5075.33    5205.42   0.46948165    2134.01    4545.46
                      14404.9    9418.28    1.6407626    9609.29     5856.6   1.3637003      3785.1    2775.61    1.5594957    4265.86    2735.41     1.104666    2808.05    2541.99    0.9438932    2222.84    2354.97
                     58691.19     64385     1.1289878   45016.91   39873.69   1.0459179    31119.99   29753.76    0.9236507   41634.21   45075.71    0.5810112   37586.41   64691.37    1.0565537   43581.54   41248.77
                      8413.37     6474.1   0.80137885    2729.16    3405.58   1.6179096     4000.54    2472.66    1.4431087     943.49     653.79   0.71357733     10224    14327.81    1.1596792    6293.37    5426.82
                      9126.87   10312.31    0.6225286     5102.5    8196.41   1.0153652      4504.8    4436.63   0.80765384    2384.17    2951.97   0.53869087   21180.69   39318.82    1.1672108    4508.83    3862.91
                      4467.19    4721.46   0.84897214    3893.14    4585.71    1.102257     3375.64    3062.48    1.0870861    1535.02    1412.05    1.3910229   33375.91   23993.79    1.3723634   23105.59   16836.35

                      1041.51    1071.54   0.77541256    2510.91    3238.16   1.1023173      805.32     730.57   0.7979987      395.56     495.69   1.9771205    11967.55    6053.02   1.4002277      1340.9     957.63

                      6058.43    8588.31   1.0212386     8252.67    8081.04   1.2138748     2865.74    2360.82   0.8240503     4343.47    5270.88   1.2968017    10866.73    8379.64   1.2791884     4431.39    3464.22

                     14110.06   26172.97   0.7111772    24950.64   35083.58   3.7039099     8551.81    2308.86   0.49652278    9129.59   18387.05   1.1477553    49388.13   43030.19   1.4710362    21964.94   14931.61
                      5913.59    3452.92    1.6456069    5953.46    3617.79   2.0821264    10025.23     4814.9   0.6945757      757.15    1090.09   0.8375588    11728.98   14003.77    1.682182     7260.92    4316.37
                      6132.58    7799.74   0.70133764    5592.95    7974.69   4.4477015     4619.65    1038.66   0.4884705      966.18    1977.97   1.0781296     5047.48     4681.7    1.703342     4672.71    2743.26
                     14622.81   15413.77    0.9390668   12082.55   12866.55   1.1042506     6432.16    5824.91   1.0575806    17877.48   16904.13   1.0439557    18924.37   18127.56   1.1688533     7850.65    6716.54
                                           0.64294285     477.07     742.01   2.3658175       95.65      40.43                                       1.108796      852.52     768.87   0.8938505      269.63     301.65

                      5635.44    4967.82   0.92038125     6187.3    6722.54   4.2049303     8591.43    2043.18   1.1589427     4895.27    4223.91   2.6742024    88726.64   33178.73   0.79761326    6835.57    8570.03
                      1361.25    1062.93    0.8367208     862.86    1031.24     5.094528     761.53     149.48   1.4211906      303.41     213.49   1.0754831      762.41      708.9   0.4118238      110.69     268.78
                      6273.42    6964.34   0.94723976    2064.85    2179.86   0.36032027     670.03    1859.54   1.0202863     1106.98    1084.97   1.0291907     4783.39    4647.72    1.019008     3573.06    3506.41
Molecular Medicine




                      6788.93    5671.42    1.3329867    7650.49    5739.36    2.2347963    4851.05    2170.69   1.5279491     4269.09      2794    1.2494069    17743.39   14201.45    1.074098     6193.99    5766.69
                      3269.75    5433.51    0.9045943    7420.55    8203.18    2.8474665    4305.91    1512.19   0.6452379     2555.91    3961.19    0.785459    14240.89   18130.66   1.1526744     5977.32    5185.61

                       3191.2    4197.03   1.6359096    10584.58    6470.15   2.4919767    10814.88    4339.88   0.9988351     4364.63    4369.72   0.77322763   28282.61   36577.34   1.1439717     7323.73    6402.02
                      1684.03    2546.09    0.8253206    5892.83    7140.05   0.43235964     1933.4    4471.74   0.5179267     2415.03    4662.88   1.1176744    18766.86   16790.99    0.6053273    5789.75    9564.66
                     45821.64   36047.55    1.7745079   16945.84     9549.6   0.90410316    5425.74    6001.24   0.7034546     4774.48    6787.19   1.2399939     6019.34    4854.33    1.1356143    4060.23    3575.36
                      6512.52    7219.24   0.92944235    5890.35    6337.51    1.0726361      3518     3279.77    0.719032     2558.92    3558.84   0.8919252     4748.94    5324.37     1.041419    2384.11    2289.29
                      1020.32     629.18    0.9905096      778.6     786.06    1.4275268     515.38     361.03                                       1.193608      652.82     546.93   0.13204785      36.98     280.05
                       1258.4    1664.26    0.8848963     854.27     965.39    0.6035902       385      637.85   1.0609585      361.32     340.56   1.0393736      299.35     288.01    1.2547187    1074.93     856.71
                     13614.92   18200.53    1.0051363    9727.89    9678.18    1.2566259    6183.53    4920.74   1.0470804     8074.55    7711.49   0.8065899     9457.63   11725.45    1.6615716   10612.74    6387.17
                      6429.86    4812.98    1.2846674    3361.82    2616.88     1.383018    1977.37    1429.75   1.3133903      953.39      725.9   1.1244174     4405.22    3917.78    0.9767953    2792.56     2858.9

                      4295.61    4747.43   0.8292358     3595.84    4336.33   0.6609484      1557.3    2356.16   0.69830847    1327.24    1900.65   1.1991689     7780.76    6488.46   1.0286351     1815.86    1765.31

                       816.14      862.2   0.9836059      985.76    1002.19   2.6558223      493.08     185.66   1.2047099      372.93     309.56   1.0736428     1057.71     985.16   1.2217456      410.14      335.7

                      3899.73    3864.24   0.90170795    4955.67    5495.87   0.92249256    3391.47    3676.42   0.59330577    2215.92    3734.87   0.66340375    3000.27    4522.54   0.9937775     2713.44    2730.43
                     16358.39   18126.66   1.2247814    22901.06   18698.08   0.5880732     1937.36    3294.42   0.78030425    4573.34    5860.97   0.72763973    7506.04    10315.6   0.71202236    1695.19    2380.81




                                                                                                                                                                                                                     UNCORRECTED PROOF
                     10995.48    10170.6   1.3487138    10783.83    7995.64      2.09796    3705.48    1766.23    0.9917755     5339.6    5383.88    1.0496322    4844.42    4615.35   0.9242618     3036.08    3284.87
                       841.57     693.17   1.0156236     1427.53    1405.57   0.61819583     321.06     519.35   0.33130288      71.25     215.06    0.6788785    1521.55    2241.27   0.8132793      585.74     720.22
                       556.83     355.03   0.8322566      655.71     787.87   0.61832887     620.66    1003.77    1.3304781      385.2     289.52   0.99764496     698.98     700.63   0.9255045      527.01     569.43

                      2181.08    2311.89   1.0715575     2173.74    2028.58   1.1043847      769.48     696.75   1.0494149      464.45     442.58   0.93179905    5723.38    6142.29   1.2317466     1929.26    1566.28
                      5826.27    5654.34   0.7790696     4229.32    5428.68   1.7570788     1255.38     714.47   1.1313676     1746.13    1543.38   1.6484811     2432.07    1475.34   1.3729166     2265.23    1649.94
www.molmed.org



                      1506.57    1432.23   1.0971856     1927.02    1756.33   1.2060996      687.32     569.87   1.0441191      529.88     507.49   1.0011699     2678.58    2675.45   1.1936852      751.58     629.63

                      5777.41    4871.91    1.101733     9612.95     8725.3   1.1107333     2488.82     2240.7   1.7904567     5927.45    3310.58   1.3122073    13626.71   10384.57   1.4681985     2777.45    1891.74
                       751.87     715.49     1.156512     1990.6    1721.21   1.6672792      589.75     353.72   0.91992515     875.41     951.61   0.8085325      2972.4    3676.29   0.69893724    2441.29    3492.86
                       875.64    1001.28   0.73134893      940.8    1286.39   1.2310971      335.08     272.18                                      0.7535921     1057.35    1403.08    1.0379204      599.7     577.79

                       684.46     924.27   0.88875896    1641.28    1846.71   1.3113792      933.82     712.09   1.0251644     1071.43    1045.13   0.97071296    1005.28    1035.61   1.0750291     1677.97    1560.86
                       552.95     392.59   1.2879499     1526.62    1185.31    0.5943271     748.87    1260.03    1.8881758     117.69      62.33   0.7047766     1146.15    1626.26   0.98900867      939.4     949.84
                      10035.8    5989.87   1.3946509     7178.77    5147.36   0.68755317    1576.91    2293.51    0.7536548    1562.56    2073.31   0.8904329     7051.65    7919.35    0.8910907    2562.18    2875.33
                     25082.18   27688.98   1.0301157    24273.42   23563.78    0.9026885    9305.13   10308.24   0.93503284   11092.22   11862.92   1.0817382     6702.58    6196.12    1.1493117    1750.85    1523.39
                       6043.2    4827.47   1.1616484     4109.25    3537.43    1.3914285     969.77     696.96    0.7064084     1252.9    1773.62   0.9370412     3884.27    4145.25    1.1428522    2335.75    2043.79

                     15638.11   13111.31   0.7192099     1623.53    2257.38   1.1243038     2008.76    1786.67   0.6183261     1845.11    2984.04   0.8983269     2525.17    2810.97   1.2082157     7290.06    6033.74


                        38.23     364.35   2.7808554     3956.49    1422.76   0.86359125      165.3     191.41   0.12902603     193.33    1498.38   0.6216727      950.32    1528.65   0.7556609      627.72     830.69
                      5575.45    3035.99   2.9708855     4301.07    1447.74   1.1725142     2045.24    1744.32   3.2560093     2332.67     716.42   0.56460637    2283.59    4044.57   0.7958447     2982.77    3747.93

                     23619.97   24720.84   0.8075214    28237.65    34968.3   1.3849891    24268.97   17522.86    1.204128    25516.45   21190.81    1.258396    37223.38   29580.02   0.9991245    35673.48   35704.74
                       259.17     295.48   1.0974296      837.24     762.91   1.3211105      268.41     203.17   0.37504488       73.1     194.91   0.92308486     541.26     586.36   0.97357136     299.86       308

                      8107.94    6800.18   1.2002939     4501.33    3750.19   0.8974302     3293.21     3669.6    1.660675     2644.16    1592.22   1.4277668      9100.4    6373.87   1.1224067     2071.02    1845.16
                     14346.26   15739.83    1.059256    68706.99   64863.45   0.45124763   16560.58   36699.54   1.2410337    22798.83   18370.84   1.0250351    66310.93   64691.37   0.6510438    19225.81   29530.75

                      3067.34    2744.81   1.7634468    10478.26    5941.92    1.325299     2430.32    1833.79   0.5947225     2830.79    4759.85   0.51685727    6242.69   12078.17   0.9114693     1472.98    1616.05
                       357.09     347.31   0.88457185     453.52      512.7     0.646008     236.51     366.11    1.296587      185.01     142.69   1.6298869      847.15     519.76   0.6172047      178.94     289.92
                       682.32    1589.86   0.45741025     1267.9    2771.91   0.68280625     204.48     299.47   1.9098995      861.04     450.83    0.596707      491.43     823.57   1.2233819       407.9     333.42

                     25703.93   20859.63   1.8338463     19186.6   10462.49   1.3847377    18740.21    13533.4   0.8216678    11587.98     14103    0.4711787    17775.98   37726.62   0.79273015   17626.83    22235.6

                      3314.19    3639.65   1.0323321     2298.25    2226.27   1.1512809     1079.51     937.66   0.9876075     1856.07    1879.36   1.1521767       3119     2707.05   0.98222935    2115.28    2153.55
                      6904.94     6114.9    0.8613534    2446.64    2840.46   1.3895744     6895.36    4962.21   0.89559275    3627.07    4049.91   0.88268715    7753.48    8783.95   0.79648054    4166.82    5231.54
Molecular Medicine




                      3125.86    3131.14    1.2131518    4929.06    4063.02   1.0318835     1158.64    1122.84   0.99998784    1648.25    1648.27   0.89860463   15080.68   16782.33    1.1972586    3736.62    3120.98
                        96.92      55.23    1.0090942     622.48     616.87                                       1.2347381      94.05      76.17   0.94738734     737.56     778.52    1.3071531     184.57      141.2
                       6582.9    6306.22    0.9247062    7829.59    8467.11    1.1716872    4201.53    3585.88    1.6425434    5534.78    3369.64   0.85768825    1878.08     2189.7    0.8728727    2603.98    2983.23
                      1466.68    1633.31   0.67934227     694.94    1022.96   0.55563694     280.68     505.15                                       0.8961003     991.06    1105.97    1.0475882    1341.51    1280.57
                     13376.05    10735.1    1.1980054    8001.73    6679.21    1.2988285    5783.19    4452.62   1.1465343     3374.56    2943.27    1.2002627    5163.47    4301.95    1.2150049    7369.09    6065.07
                       437.37     435.12   0.76957774     644.96     838.07    1.1059552     233.81     211.41     2.66148      355.76     133.67   0.73684406     205.27     278.58   0.41151953      108.6      263.9
                      5039.16    5224.46    1.0473244    9044.19    8635.52    2.9806042    2973.57     997.64   1.4971718     4293.29     2867.6    1.4441639   13857.72    9595.67    1.0946335    4967.72    4538.25
                      1281.35    1253.65   0.92688566    2377.23    2564.75   0.94621867     609.45     644.09   0.6085149       73.18     120.26    0.9797294    1533.59    1565.32    0.9294346     833.74     897.04
                      5040.46    6405.78   0.55525655     4034.2    7265.47    0.5673068    2248.22    3962.97   1.0600405     2676.21    2524.63    1.5201453    2080.03    1368.31    0.9542115    3255.97    3412.21
                       570.56     556.09     1.046629    1838.77    1756.85    0.9581843     517.18     539.75   1.1201571       707.2     631.34   0.98792285    2759.96     2793.7    1.2197734    2117.49    1735.97
                        303.4     278.79     1.132366     411.23     363.16    0.4910392     212.07     431.88   1.0246924      255.63     249.47    0.6771032     386.24     570.43    0.7442258     444.34     597.05
                      5647.12    5783.27    1.2065332    4208.75     3488.3    0.8822304    1735.85    1967.57   1.3595499     1452.38    1068.28     0.681564    3713.29    5448.19   0.90947074    1482.41    1629.97
                      1915.12     1914.6    0.9988291    1518.48    1520.26    0.6415702     1413.7     2203.5   1.0271306     1925.12    1874.27   0.93705934     458.55     489.35   0.84331584     791.57     938.64
                      3750.77     4236.9    0.8631323    3808.83     4412.8   0.71678615    1145.03    1597.45   1.0457467     1096.34    1048.38    1.0995559    4329.38    3937.39    1.1313022    2308.92    2040.94
                      33623.6   64879.66    0.8384552   32237.68    38448.9    1.9584694   33088.73    16895.2   0.8448858    37340.32    44195.7    1.4965249   21065.07   14075.99    0.8603072   45533.16   52926.63
                      4179.14    4486.88    1.3143653    1875.31    1426.78   0.63595814    1661.11    2611.98   1.2030038     2963.66    2463.55    1.0336382    3725.17    3603.94    1.1518575    3517.22    3053.52
                     27938.08   37792.9    0.7165719   9977.59    13924.06   0.8581091   10823.03   12612.65   0.6757471    9521.29    14090.02   1.0483553   29746.82    28374.75   1.6419389   14724.99   8968.05




                                                                                                                                                                                                                 UNCORRECTED PROOF
                     22383.12   27195.98   0.822037    26532.55   32276.59 0.42827302    30429.04   71050.56   1.2823389    16893.84   13174.24   1.2830034   17956.84    13995.94   1.2257078   20988.65   17123.7
                     3112.08    2720.88 0.98366493     3524.56    3583.09 0.60428613     1048.66    1735.37    1.3523829     394.72     291.87    0.9257101    1526.82    1649.35    0.9411964   1727.66     1835.6

                                           1.2555811    283.46     225.76                                                                         0.5719868     124.43     217.54    0.3881766    132.31     340.85

                      896.71     787.28    1.0258399   2187.07    2131.98    0.9195183   2240.25    2436.33 0.55378413       964.62    1741.87    0.9728819    3168.91    3257.24 0.86132675     2048.95    2378.83
www.molmed.org




                     4121.39    3585.61 0.93595517     3568.46    3812.64    0.9596855    2282.9     2378.8    1.0936913    1696.72    1551.37    1.4128859    5124.17    3626.74    1.3225033    1622.5    1226.84
                     7230.58    3261.16    1.2217277   8526.12    6978.74 0.82122946     4635.75    5644.89    0.5310131    2456.44    4625.95    1.3705742   48150.37    35131.53   0.6798458   11139.62   16385.51
                     6031.85    7238.92    1.1408978   5063.19     4437.9    1.6506157   1103.42     668.49    0.6899059     1689.2    2448.45    0.7700345    3837.96    4984.14    0.8697814   2471.91    2841.99
                      2301.8    2217.88 0.83136654     3068.84    3691.32    9.689794     340.79      35.17    0.91353977    611.35     669.21 0.83937573       537.83     640.75    1.373877     454.19     330.59
                     5954.96    6230.31    0.9191297   3515.57    3824.89    1.1342454   1883.63    1660.69 0.95713717      1304.98    1363.42    0.7719214     5788.7    7499.08    1.0695547   2066.69    1932.29
                      126.64     194.71    0.6494544    475.55     732.23    0.7799217    167.34     214.56    1.7109253     143.29      83.75    1.354335      824.79       609     1.0118461    615.85     608.64
                     1348.52     972.93    0.7024301   2230.37    3175.22    4.1663685     232.9       55.9                                       0.7958195    9322.35    11714.15 0.83080775    1260.46    1517.15
                     19420.95   21778.44   1.8077644   18224.76   10081.38   1.2177424   9515.11    7813.73    1.9617354    6481.24    3303.83    1.5681646   21339.41    13607.89   1.0208023   3538.08    3465.98
                     3803.74     3922.8    0.9080242   4281.77    4715.48    1.2778486   2778.03    2173.99    1.3363587    2737.37    2048.38    1.3464653   14425.29    10713.45   1.3931879   2742.95    1968.83

                     3466.03    3117.95 0.73926675     1931.46    2612.67 0.72169566     1670.48    2314.66    1.2033737    1227.79    1020.29    1.5996091    5550.34    3469.81    1.068015    1153.83    1080.35

                     11315.82   11909.26 0.99565834       7249    7280.61    0.8981386   2494.14    2777.01    1.0438759    4376.22    4192.28    1.0880969    5307.16    4877.47    1.2453074   3497.72    2808.72

                     8572.71    6549.86    2.1210387   5419.72    2555.22    1.9117777   3301.43    1726.89    1.6215012    2523.51    1556.28    1.8358407   10047.63    5473.04    1.106195    3468.74    3135.74

                     19965.45   17102.38   1.662467    22926.85   13790.86   1.9217751   17924.36   9326.98    2.6058757    20788.06   7977.38    2.2374604   144744.38   64691.37   1.2017889   14464.25   12035.6
                     35246.86   30044.73 0.88374233    23090.57   26128.17   1.0476733   20053.62   19141.1    1.5368432    24050.55   15649.32   1.5191965   67577.54    44482.42   1.1458269   14966.23   13061.51
                     3918.16     2739.2    1.6407087     26041    15871.8    1.5025169   3919.06    2608.33    2.0374463    7099.38    3484.45    1.5783973   15977.39    10122.54   1.0515097   2498.24    2375.86

                     3012.94    2756.93    1.2760483   4566.39    3578.54    2.1324003   2451.77    1149.77    1.5235337    5921.61    3886.76    1.2228979   10741.03    8783.26    1.1164536   2360.06    2113.89

                     1823.23    1664.04    1.2214719   3140.49    2571.07     8.40272    10921.27   1299.73    1.6360699    6949.78    4247.85    1.6313839     45651     27982.99   1.1012363   7664.77    6960.15

                      6315.1    4713.84    1.2457874   7773.75    6240.03    1.6505212   9945.43    6025.63    1.7618002    3040.92    1726.03    2.2617693    9605.35    4246.83    1.0374767   5824.29     5613.9

                                           1.000058    1893.45    1893.34    0.1569152     53.96     343.88                                       1.1185129    4131.63    3693.86    1.0444013    1701.1    1628.78
Molecular Medicine




                     19283.84   12071.41   1.9013883   16904.92   8890.83    3.8260543   16215.2     4238.1    2.9821374    14853.52   4980.83    2.001083    57481.21    28725.05   1.1391492   9954.17    8738.25
                     17586.63   19793.78 0.93660927    21111.53   22540.38   1.3203479   12388.56    9382.8    1.0758903    3116.51    2896.68    2.177034    116991.87   53739.11   0.9892273   9311.29    9412.69
                     6567.99    6446.46    1.2733458    9583.8    7526.47    1.2211932   6255.44     5122.4    1.1889124     1929.7    1623.08    1.8784088   22211.47    11824.62   0.7723314    2847.3    3686.63
                     19385.77   12101.15   1.8054609   26819.58   14854.7    7.8020415   9781.03    1253.65      2.11408    5303.36    2508.59    3.1908357   21425.09    6714.57    1.015599    5652.53    5565.71
                     3691.16    3981.95 0.96844214     2579.93      2664     1.3415824    877.69     654.22    1.2706435    1013.91     797.95    1.3375213   10544.59    7883.68    1.0813777   5992.26    5541.32
                       604.7     661.81    0.6856004    942.68    1374.97    0.4941485    216.61     438.35                                       2.0668635     518.39     250.81    0.9057512    511.36     564.57
                     2942.22    2654.66 0.79449904     2765.81     3481.2    1.1253899    1453.7    1291.73     0.938801     945.72    1007.37 0.94232243     12732.51    13511.84   0.8564629   1461.04     1705.9
                     3151.67    4305.75    0.8150121   11704.52   14361.16   1.2543725   8930.58    7119.56 0.83261377      12815.1    15391.41   1.2704035    7417.01    5838.31    1.1027766   3481.51    3157.04
                     4307.88    4949.34    1.5773197   13822.18   8763.08    0.4723593   7416.74    15701.48   1.4187956    5926.38    4177.05    1.2232828    9097.75    7437.16    1.4603766   3569.92    2444.52

                     21117.46   28389.66   0.5429933   32617.68   60070.13   2.5991094   35094.94   13502.68 0.65911436     26520.31   40236.28   1.0907115   70559.62    64691.37   1.1360694   73197.11   64430.14
                      664.52     750.09 0.66646564     1514.27    2272.09    1.0818763    809.99     748.69     0.527311     440.31     835.01    1.8729236    2473.57     1320.7    1.6269134    624.93     384.12
                      3331.81    3248.08    0.9547628    2282.79    2390.95    1.0859802   1139.28    1049.08 0.85295576     1140.18    1336.74 0.88390607       670.54     758.61      1.73578    5857.65    3374.65




                                                                                                                                                                                                                   UNCORRECTED PROOF
                     20132.08    19126.43   1.1057254    17848.1    16141.53   1.1225477   3765.16    3354.12    0.5427543   4096.72    7548.02    0.6499926    5478.56    8428.65    0.7919231     2887.7    3646.44
                     18536.54    22878.38   1.8409314   31740.16    17241.36   0.4695344   4642.85     9888.2 0.70335394     8866.22    12605.63 0.52644414     6948.02    13198.02 0.94315165     8022.75    8506.32
                       222.75      153.4    0.6042246      442.8     732.84    0.5101306     375.4     735.89                                      1.3115245     997.48     760.55    0.5417036     116.06     214.25
                       3008.5    2108.95 0.80311364      1421.72    1770.26 0.26048073      555.47    2132.48    0.9931642    586.97     591.01 0.66771996       566.34     848.17    1.1590573      555.2     479.01
                       353.41     279.16    1.3578252     714.99     526.57    2.9861703     349.8     117.14    1.8992809    346.03     182.19    1.3022056     769.33     590.79    0.6710859     350.28     521.96
www.molmed.org




                       448.25     529.74    1.1411375    1180.21    1034.24    0.8303419    803.09     967.18    1.0776235    416.62     386.61    0.8490148    1933.02    2276.78    1.0866846    1473.24    1355.72
                      1630.11    1480.59    0.7194729    1393.18    1936.39 0.78069025     1323.27      1695     0.5105126    330.95     648.27 0.91999155      2578.58    2802.83    0.9470847    2102.14    2219.59
                       167.36     166.63    0.9000482     820.97     912.14 0.74550265      211.35      283.5    0.7719072    167.72     217.28    1.6026601    1201.37     749.61    0.9201688    1220.88     1326.8
                       8643.9    9290.27    0.8089453    2238.74    2767.48    1.5343659   2343.79    1527.53    1.1367329    824.12     724.99    1.1479933    2746.31    2392.27    1.2729402    2744.79    2156.26
                       7943.9     8061.9 0.93771225      3090.84    3296.15    1.3754121   1472.86    1070.85 0.90840405     1614.67    1777.48     1.074248    5673.49    5281.36 0.94630724      2321.32    2453.03

                      1208.85     802.66    1.2042575    2264.57    1880.47 0.31886753     1650.13    5174.97    1.0779891   2435.49    2259.29      1.45603    3053.63    2097.23    0.8554312    1440.05    1683.42

                      5000.83    4875.66    1.0315466   10639.34    10313.97   1.4089935   5845.66    4148.82    0.9775647   3613.04    3695.96 0.76430345      6349.81    8307.97    1.0398078    7397.65    7114.44

                      3809.73    3581.47    1.3874183    2537.81    1829.16 0.35218728     1300.05    3691.36    1.1460559   2242.27    1956.51    0.7905586    2592.21    3278.96    1.3903557    4646.11    3341.67
                     15030.69    13329.96   1.8039066    16084.1    8916.26    1.5767941   1397.97     886.59 0.84074825     3289.89    3913.05 0.77918327      6193.12    7948.22    0.7379376    1558.79    2112.36
                      1544.35    1364.72    1.245555     2241.04    1799.23    0.6502009    789.89    1214.84    1.129042    1268.49    1123.51    0.6341538    2372.68    3741.49    1.1067609    1626.85    1469.92
                        504.8     527.18    1.0030547     1963.6    1957.62    0.5304303    508.81     959.24    0.9056305    601.23     663.88 0.78289956      2518.76    3217.22    1.0007513    2531.06    2529.16
                     14888.42    14603.67   3.1904671   116844.23   36622.92 0.56540835    19012.63   33626.37   1.2839499   56972.64   44372.95 0.48076108     40171.66   83558.47   0.7904576    30746.16   38896.66
                                            0.5770926     438.55     759.93    0.4474207    148.66     332.26 0.72633874       46.66      64.24    1.5334249    7749.73    5053.87      0.95474    1362.71    1427.31
                     20181.71    14146.91   1.2941217    6747.02    5213.59 0.91221774     3231.96    3542.97 0.48413375     2325.89    4804.23 0.82860667      23176.75   27970.75 0.87533265     3321.94    3795.06
                      4718.78    5723.07    0.8026912    5476.04     6822.1    1.3377323   1743.48    1303.31    0.7725453    2556.7    3309.45    0.8770189    4468.35    5094.93    1.0056796    2105.35    2093.46
                      2018.76    2741.24    0.8299196    1390.19    1675.09    1.1339799   1753.87    1546.65    0.4150458    298.53     719.27    0.7988415    1791.41    2242.51    0.8251248    1418.67    1719.34
                     11337.67    12670.66   1.1617624   14066.63    12108.01   1.5063934   12842.32   8525.21    1.1307116   7724.23     6831.3    0.8822524    24420.72   27679.97   1.4138181    13942.82   9861.82
                      1041.32     1285.3    0.9695943    3298.23    3401.66    0.8612021    651.93       757     1.0019759    816.43     814.82    1.0015808    2787.85    2783.45    1.2771398     3930.5    3077.58
                      3099.98    3642.26    0.9195492    2606.83     2834.9    1.2615539    602.72     477.76                                      0.9248882    6783.26    7334.14 0.91894054      1874.51    2039.86
                       653.89     727.03    1.0914825     593.57     543.82 0.35423097      634.75    1791.91    0.6332145    482.94     762.68    1.1476446    1115.04     971.59 0.72658134       345.86     476.01
Molecular Medicine




                     20704.73    20764.81   0.9343184   12367.33    13236.74 0.83444023    12115.78   14519.65 0.88816434    5950.39    6699.65 0.96349025      40139.61   41660.63   1.9073807    8459.52    4435.15
                       739.69     621.78    0.6630026     696.04    1049.83 0.32037833      207.65     648.14                                      0.7224146     807.32    1117.53    0.55352855    232.72     420.43
                     48488.45    56530.65 0.88171184    38740.76    43938.12 0.94461447    15072.42   15956.16   1.0112678   14322.05   14162.47   1.0854379    44967.02   41427.54   1.7069571    14444.34   8462.04
                     49659.15    31715.93   0.6957029   13681.08    19665.12   1.5646819   8475.96    5417.05 0.64601123     6184.55    9573.44    0.5221784     9568.1    18323.43 0.48550054     7116.19    14657.43
                     13463.11    14173.71   1.7939881    42122.3    23479.7    1.3185964   4795.01    3636.45    0.7649037   3092.59    4043.11    0.7359298    47608.31   64691.37 0.90970045     10472.48   11512.01
                      8172.03    9915.65    1.1536026    9126.67    7911.45    0.6256462   2992.04    4782.32 0.69478595     5231.87    7530.19 0.88653225      11448.5    12913.8    1.1899233    12990.5    10917.09
                      2008.16    1578.99 0.80916566      1618.93    2000.74    1.2589796   1099.92     873.66    1.9849173   1402.88     706.77    1.1451471    9894.06    8639.99    1.2950144    2665.58    2058.34
                       165.48      16.07    1.2794594     375.79     293.71                                                                        0.89618284   1074.12    1198.55    1.4160877     623.73     440.46
                      3025.44    2931.26 0.85825545      2956.81    3445.14    0.8997573   2205.98    2451.75    1.2310317   2435.35     1978.3    1.1381358    10168.8    8934.61    0.9822952    2916.12    2968.68
                      2771.52    1920.17 0.59554416        678.7    1139.63 0.82067484     1404.15    1710.97     1.36152     297.71     218.66    1.2083732    1781.71    1474.47    0.5963622     805.25    1350.27
                     115339.88     64385    1.4274348   64226.89    44994.62   1.1387763   72992.94   64097.7    1.8007482   60987.6    33867.92   1.1682802    75577.65   64691.37   0.9863174    63730.64   64614.74
                     17772.85    13926.51   1.1417295    6855.56    6004.54    2.468434    6523.01    2642.57    1.345339    5120.32    3805.97 0.75208825      13065.39   17372.15    1.511423    8951.01    5922.24
                     20818.36   36833.22   1.3518835   52556.7    38876.65   0.7929363    20099.5   25348.19   0.722192    25132.75   34800.65   1.0787847    69788.06   64691.37   1.6255151   66811.32   41101.63




                                                                                                                                                                                                                UNCORRECTED PROOF
                      930.07    1425.65    0.7956337    481.43     605.09    1.9968349    220.81     110.58    1.1572213    185.41     160.22    0.9377852     441.95     471.27    1.294664     404.22     312.22

                     5640.11     5130.4    1.4272782   12773.54   8949.58 0.39861068      5801.91   14555.33   1.1438642   6559.18    5734.23    1.2247027    9838.38    8033.28    1.2846456   8476.76    6598.52

                     20113.28   23147.55   1.2206448   28611.39   23439.57   0.8384509    8387.31   10003.34   0.339942    3993.71    11748.21 0.38270983     28349.46   74075.6    1.4493979   10999.22   7588.82
                     7476.01    9398.07    1.2674687   12330.48   9728.43    0.7872719    4455.55   5659.48 0.59655416     5200.24    8717.13    1.1341137    29699.66   26187.55   1.2302779   10080.11   8193.36
www.molmed.org




                                           1.0553201    483.21     457.88    1.2044036    277.88     230.72    1.4898045    246.22     165.27 0.74125797       328.57     443.26 0.70523894      272.73     386.72
                     4900.34    6663.12    1.5694808   17451.15   11119.06   0.75022036   680.99     907.72    0.869348    2067.04    2377.69 0.39814302      2662.04    6686.14    1.3846475   2387.34    1724.15

                      333.04     256.51 0.66263497      448.14      676.3    0.7316258    221.09     302.19                                      1.2730042    1182.99     929.29    1.5923307    261.19     164.03

                       356.2     234.38    0.8257755    1759.1    2130.24    3.6750534     293.6      79.89                                      1.0933906    1799.71    1645.99    1.073026     811.39     756.17
                     2844.86    3291.42    1.3744029   8816.41    6414.72    1.5022819    4420.57   2942.57    1.4826441   4684.74    3159.72 0.78116417       830.69     1063.4    1.1568893    984.64     851.11
                     2646.02    2662.36 0.95305616     5676.25    5955.84    0.7649295    970.03    1268.13    1.1204154   1112.27     992.73    0.7578445    3365.11    4440.37    1.1033921   2475.03    2243.11
                       55.63       0.26    0.905774     510.15     563.22    1.3506528    347.55     257.32 0.64644545      370.73     573.49    0.9076629     327.63     360.96    0.7588426    386.82     509.75
                      300.61     273.63 0.64389366      389.15     604.37 0.26363468      169.38     642.48    1.7760737    220.02     123.88    1.0269654      666.1     648.61    0.5728075     55.19      96.35
                     4948.96    5070.33     1.18982    8400.51    7060.32    1.9224517    6746.46    3509.3    1.0431389   7448.71    7140.67      0.98076    8410.37    8575.36    1.0134239   3123.94    3082.56
                                           0.8254303    274.34     332.36 0.73798686      139.45     188.96                                       1.320591     611.46     463.02    0.6368601    152.77     239.88
                                           1.181676     211.65     179.11                                                                        1.4380069     395.38     274.95
                     1108.29    1098.35    1.2760887   1525.73    1195.63 0.96635467      346.96     359.04    6.7123456    222.38      33.13    0.7852855     1018.9    1297.49    1.7744516    736.22      414.9
                       1745     2131.25 0.81309164     2450.78    3014.15    0.5293722    598.99    1131.51    2.1515472    285.79     132.83    1.0824443    3193.07    2949.87    1.196161    1560.44    1304.54
                     2485.48    3513.51    1.2654293   5098.68    4029.21     0.886417    929.94     1049.1    0.6083346   1512.04    2485.54    1.2739573    2935.86    2304.52    1.0455244   2458.54    2351.49
                      227.02     353.05    0.9424739      482      511.42    1.7054621    241.05     141.34    1.4008409    183.23      130.8    1.5217509     949.04     623.65 0.82166266      292.06     355.45

                      378.09     308.55 0.63501376      387.46     610.16 0.64007044      170.95     267.08                                         1.0046     858.27     854.34 0.66028535      219.36     332.22
                      447.92     633.97 0.57033384      387.77      679.9    0.36442888   146.73     402.63    0.7207433    109.38     151.76    0.7314605     103.37     141.32 0.39530823      122.17     309.05
                      285.32     270.83    1.129872     405.85      359.2    0.6502651    141.01     216.85    2.0383282    252.61     123.93    1.0970057     571.54       521     0.7116495    306.97     431.35
                     20680.37   20778.52   1.2679459   16219.07   12791.61   1.8823696    5546.76   2946.69     0.94745    6706.61    7078.59 0.87753195      23218.04   26458.34   0.9268654   16113.62   17385.07
                      387.48     487.06    0.551639       313       567.4    0.16302645   136.37     836.49    1.0602384    195.72      184.6    0.7024774     210.68     299.91    0.1917936     39.03      203.5
Molecular Medicine




                     5065.47    5532.74 0.84880763     2269.89    2674.21 0.26155755      1898.39   7258.02    0.8162571   2712.61    3323.23    0.9760929    6982.89    7153.92    1.1135474   3218.23    2890.07
                     1534.81     1775.4 0.88164645     1049.08    1189.91 0.32857826      769.32    2341.36    0.7935715   1146.06    1444.18    0.8460865     666.75     788.04 0.85728264      954.73    1113.67
                     5404.05    4959.41    1.7573023   7720.04    4393.12    0.5940156    680.13    1144.97    1.023425     667.14     651.87     0.539377    2175.55    4033.45 0.73461616      954.81    1299.74
                     12538.77   8554.61    2.2489974   18126.11   8059.64    0.6392943    1757.03   2748.39    1.0434357   3246.64    3111.49    0.48880336    7697.9    15748.46   0.7505524   4140.97    5517.23

                      857.28     755.88    1.3732826   1778.03    1294.73 0.51131207      474.38     927.77    0.3283309     35.88     109.28    1.0210406    1091.38    1068.89 0.71805865      658.23     916.68

                     1027.51     869.09 0.89652973     2240.41    2498.98 0.83245826      1753.64   2106.58    1.6961772   2253.66    1328.67 0.85455775      3625.82    4242.92    1.9012215   1080.16     568.14
                     3977.73    3021.79    0.7531671   1375.14    1825.81    0.5143447    1128.57   2194.19    0.9386617   1314.99    1400.92 0.97280234      4083.97    4198.15 0.66068625     1363.26     2063.4
                     9232.29    10974.76   1.1202921   7801.77    6964.05 0.40596503      6032.64     14860    1.2303907   5674.34    4611.82    0.7441275    7015.85    9428.29    1.1025815   10077.33   9139.76

                     32139.74   36679.61   1.3999041   26771.04   19123.48   1.3134195    6578.17   5008.43    1.2807988   12840.93   10025.72   1.5649474    16007.69   10228.9    1.1135437   4119.21    3699.19
                     6248.07    9683.19    1.0943053    5073.9    4636.64 0.59738433      2134.52   3573.11 0.34268543       866.6    2528.85    0.6383128    21919.74   34340.12 0.71516687    2423.35    3388.51
                     8829.98    7864.17    0.919196    4272.91    4648.53    0.7255908    2746.63   3785.37    1.4634082    767.06     524.16    1.3644999    18736.63   13731.5    1.4297838   8247.65    5768.46
                      9084.39    7800.73    1.4103684    10853.97    7695.84    1.3382169    4977.19    3719.27    1.1443601    6916.65    6044.12    1.2272208    4900.98    3993.56    1.3554122    3488.14    2573.49




                                                                                                                                                                                                                      UNCORRECTED PROOF
                                            1.3765205      323.62      235.1    4.5464144     124.89      27.47                                       0.8043972      364.4     453.01 0.27954936        14.64      52.37
                      8318.13    4223.69    2.1187053     5684.19    2682.86    4.385989    19858.53    4527.72    1.5894932    4372.33    2750.77    2.6253755    20717.52   7891.26 0.96951467      9371.59    9666.27

                     13792.13    15443.93   1.3638837     9550.76    7002.62    1.725512     1316.79     763.13    0.6475771    2221.96    3431.19 0.57715666      11687.63   20250.36   0.8587426     2549.1    2968.41
                       321.38     249.78 0.78916955        676.05     856.66    1.4178071     274.53     193.63    2.5067122     235.28      93.86      1.05848     451.23      426.3    1.1430875     319.07     279.13
                        976.5     640.28    1.5115091      1124.2     743.76    1.7258159     506.13     293.27    14.110821     375.63      26.62    1.2800962    5731.08    4477.07    0.8456002     286.65     338.99
www.molmed.org




                     31394.45    32526.09   1.4103607    23264.97    16495.76   1.2305505    8522.56    6925.81    1.4847296   15693.34    10569.83   1.0646298    28992.16   27232.15   1.3971739      8973     6422.25
                      3436.45    3128.63    1.0880742     3669.28    3372.27 0.42556724      2508.74    5895.05    1.0046254    1941.72    1932.78    0.6780622    12791.5    18864.79   1.1966909    2388.26    1995.72
                      1085.99    1010.44    0.6762644      878.88    1299.61    0.8093235     648.26     800.99 0.98793304       171.11      173.2    0.78794605   1514.85    1922.53    1.0526893     969.79     921.25
                       942.39    1078.26 0.85454565        994.58    1163.87                                       2.0276911       45.4      22.39    0.94829607   1882.51    1985.15    0.7880804     747.51     948.52
                        553.8     570.93    1.3889663     7114.23    5121.96    3.114399     6408.28    2057.63    1.6318318    7277.17    4459.51    1.2011788    4567.23    3802.29    1.0777973    3826.73    3550.51
                         47.9     235.97     1.169938      442.88     378.55    0.7674132     211.76     275.94    0.8367932     253.95     303.48 0.67987865        504.3     741.75    0.8308314     520.25     626.18
                                            1.0559175      444.14     420.62    2.7383063     265.78      97.06    42.02325       72.28       1.72    0.88247573     465.1     527.04

                      2296.58    2167.67    1.0452468     2186.28    2091.64    4.124778     2087.88     506.18    1.2943991    1295.81    1001.09    1.4547915    2493.44    1713.95    1.0797987    1890.49    1750.78
                     15527.76    18434.88   1.4317238     10939.1    7640.51    0.7072571    5542.01    7835.92    1.5295616    8451.96    5525.74    1.1180785    35715.81   31943.92   1.0521969    8694.66    8263.34
                     87071.46      64385    0.87122923   59952.55    68813.75   1.4084537   47614.61    33806.3 0.68423367     26829.56    39211.11 0.95519865     55260.14   57851.99   1.077088    69595.76    64614.74
                     21083.95    18864.05   1.0890676    19513.41    17917.54   0.9788749    7041.38    7193.34    1.3382903    6879.08     5140.2     1.097007     9273.9    8453.82    1.2995774    8560.55    6587.18
                      1699.95    1496.92 0.72107536        687.43     953.34    1.449645     1739.98    1200.28    0.5868255     556.07     947.59    1.0942862    3234.94    2956.21    0.9611771    1860.07     1935.2
                       509.01     1270.4    0.7980212      752.51     942.97    0.6228109      293.4     471.09    0.6853413      100.8     147.08 0.75223076       533.64     709.41    2.0065272     322.79     160.87

                     57164.31    42263.05   1.7902995     77389.6    43227.18   0.7722003   23385.43    30284.15   0.870008    26643.88    30624.87   0.6272124    40575.23   64691.37   1.1067058   35569.06    32139.58
                      2007.14    2049.04    1.0898913     4836.97    4438.03    1.3439754    1179.11     877.33    1.1716627    1787.43    1525.55    0.7731372    1703.09    2202.83    0.865748     2420.06    2795.34
                        244.1     316.51     1.027295     2189.34    2131.17    1.2246604      776.3     633.89 0.78156847      1072.14    1371.78    0.9171339    3493.84    3809.52    1.0305197    1777.09    1724.46
                       666.67     551.66    1.0822295     2564.57    2369.71    1.9044312     696.66     365.81    0.8432989     916.16     1086.4    0.8318023     3472.7    4174.91 0.94708264      1142.39    1206.22
                        302.4     305.28 0.78923196        768.12     973.25    1.0309689       259      251.22                                       0.9577579    1079.01     1126.6    1.1559967     362.22     313.34

                      3813.65    3861.16    1.0366544     5391.94    5201.29    1.1157756    3984.97    3571.48    0.7158078    1322.82    1848.01    1.5789652    7570.27    4794.45    1.0982537    3179.62    2895.16
Molecular Medicine




                      6789.15    6598.05    1.0959505     3506.68    3199.67    1.246393     3157.45    2533.27    0.8732963    3957.15    4531.28 0.71624094      1888.62    2636.85    0.9025201    3898.95    4320.07
                      5031.43    7361.56    0.8300682     4967.85    5984.87    2.1379008    2731.66    1277.73 0.66912687       640.06     956.56    1.1529586    21715.55   18834.63   1.2369748     7983.3    6453.89
                      2664.45    3122.22    0.7974729     3449.23     4325.2 0.85704386      2373.48    2769.38    0.625494     2092.14    3344.78    1.9316851     7941.1    4110.97    0.7777994    2877.78     3699.9
                     145319.88     64385    3.6452258    236441.92   64863.45   10.347353   663241.44   64097.7    2.8469315   183035.53   64292.21     3.91041    252969.8   64691.37   1.7249185   111455.16   64614.74

                      2976.29    3524.35    1.2293835     2426.09    1973.42    0.8441181     1525.6    1807.33    0.8339684    2214.67    2655.58    0.9781191    4996.33     5108.1    1.2178229    3445.16    2828.95
                       336.24     247.14 0.80288464        499.33     621.92 0.61113816       288.72     472.43    2.2005978     198.78      90.33    0.6955861     306.51     440.65    0.488534       119.3      244.2
                      13129.3      14155    1.4616572    10668.08    7298.62    0.8431289     2587.9     3069.4    0.5135996     709.43    1381.29 0.85628176      7779.14    9084.79    0.9864219    2707.59    2744.86
                     19047.25    20366.88 0.82332003     11333.42    13765.51 0.76590014     1338.51    1747.63 0.17923956      1314.17    7331.92    1.0703794    18304.9    17101.32   1.235091     6458.76    5229.38
                      7341.79    9153.49    1.3699232     9267.12     6764.7    0.548475     2384.55     4347.6 0.40024915       501.18    1252.17    1.2438747    24904.4    20021.63 0.96101385     3361.29    3497.65
                      1183.98    1822.88    0.7989647     1978.62    2476.48    0.7791527     1353.1    1736.63 0.28845215        294.7    1021.66    1.0373573    4306.61    4151.52 0.87162656        3346      3838.8
                      2817.75    2594.52    0.7065204     2005.67     2838.8    0.8299847    1219.48    1469.28    0.9222079     351.02     380.63    1.0444471    1687.44    1615.63    1.2872651     573.94     445.86
                      1425.89    1474.03    0.6879065      941.29    1368.34    0.259219      376.78    1453.52                                       0.85628664   1252.91    1463.19    0.8297387     566.28     682.48
                     26260.89    16270.72   3.2601106    24405.19      7486     1.2299107   4866.88     3957.1    1.327204     5339.66    4023.24    0.4505508     8035.11    17833.97   1.0996037   7965.98    7244.41




                                                                                                                                                                                                                     UNCORRECTED PROOF
                       378.26     409.61    0.7536912     1000.02    1326.83    1.5957745    409.38     256.54    11.87742       55.23       4.65    0.7203754      437.52     607.35    1.0120062    466.97     461.43
                      5694.02     6438.6    1.1671273     4481.43    3839.71    0.9028589   3763.73    4168.68    1.1200438    3070.32    2741.25    1.7973945     41101.2    22867.1    1.8896605   2645.26    1399.86
                      4713.43    4871.95    1.0780437     9842.29    9129.77     0.82014     5319.1     6485.6    1.4128808    6410.17    4536.95    1.4994926    17994.06    12000.1    1.2934749   8413.99    6504.95
                      6444.61    7255.88    0.9198215     3252.59    3536.11    0.6291799   1645.06    2614.61 0.49916083       615.66    1233.39 0.57769495       2277.47    3942.34    0.7025793   1312.65    1868.33
                      2362.95    2547.98    0.8747317     1891.24    2162.08    1.2774898   2698.02    2111.97    1.4104832    1065.07     755.11    0.7537224     2327.51    3088.02    1.0376893   1900.03    1831.02
www.molmed.org




                                            0.7956847      432.94     544.11    1.1592109    173.36     149.55    1.8175346      89.35      49.16    0.7466615      251.05     336.23
                      3430.52     4016.7    0.8852959      1941.1     2192.6 0.97137016     1532.89    1578.07    0.7636023     742.42     972.26 0.91442555       5146.14    5627.73    1.3135409   3965.79    3019.16
                        4945     3664.34    1.0518584     4409.58    4192.18    1.7058693   1227.68     719.68    1.4325409    2458.67     1716.3    0.6500048     7586.16    11670.93   1.2111866    1967.5    1624.44
                      9918.06    10663.13   1.4038029    13777.54    9814.44 0.82123995     3888.67    4735.12 0.97887915      4311.63    4404.66    0.8318535     8309.56    9989.21    1.0375823   6016.94      5799
                      1561.39    1334.49    1.1133882     1848.77    1660.49    1.8426886   1175.93     638.16    0.6754301     694.43    1028.13    0.9311925     9845.48    10572.98   1.0372479   3976.58    3833.78
                     24946.98    16956.37   1.7005733    11301.84     6645.9    1.4538343   14639.56   10069.62   1.5528457    8922.03     5745.6    1.9510111    27342.15    14014.35   1.3898933   8173.81    5880.89
                      1040.53    1610.76    1.5041262     4959.42    3297.21    1.4343956   1005.21     700.79 0.42848396      1518.56    3544.03 0.48122278       1215.15    2525.13    0.9166126   1173.75    1280.53
                       527.97     484.61    0.8511203     1085.97    1275.93    1.2425065    723.35     582.17 0.79510665       475.76     598.36 0.86266065       3879.92    4497.62    0.9624796   2274.32    2362.98
                      9138.01    9847.38    1.5061766    13754.45    9132.03 0.72600496     7763.89    10693.99   5.863236    12398.75    2114.66     2.440096    72159.56    29572.43   1.5618256   18089.69   11582.4

                     83305.05      64385    4.0890207      147049    35961.91   1.8028034   34599.8    19192.22   2.1889927   108511.92   49571.62   1.7007921    110026.57   64691.37   1.0323408   36368.87   35229.52
                     82074.73      64385    1.5499612    98261.53    63396.12 0.61953175    59402.67   95883.18   1.2577051   66092.02    52549.7    1.4768399     95538.8    64691.37   1.0568184   23578.93   22311.24
                     20785.49    17670.59   1.6675872     13527.3     8111.9    0.8070151   3949.29     4893.7    2.154458     9310.62    4321.56 0.81888425       6366.94    7775.14    1.268363    4190.95    3304.22
                       151.57      23.93    0.83377594     332.81     399.16    0.7980493    135.82     170.19    2.0105512     110.52      54.97     1.113712      495.78     445.16    1.0757731    804.56     747.89
                      3063.95    3622.59    1.1512158     7560.23    6567.17 0.54470164     2326.96    4271.99    0.9540343    2980.05    3123.63     1.102538     6454.29    5854.03    1.0778018    6625.7    6147.42
                      1065.08    1058.84      1.14171     1912.33    1674.97    2.0375974     754.4     370.24 0.92879623        870.7     937.45    1.0286607      532.98     518.13    0.9335652   1003.62    1075.04

                        369.9     148.28 0.76000637        334.57     440.22    0.8609163    273.78     318.01                                       1.0937525      683.65     625.05 0.80390435      355.39     442.08

                         2.68     238.88     1.127169      284.52     252.42    0.4311141    114.81     266.31    1.0158712      86.41      85.06    0.5567204      195.96     351.99    0.9519875    146.33     153.71

                     100802.41     64385    1.4702013    41554.83    28264.72   6.6632805   56180.65   8431.38    1.8630066   35647.96    19134.64   1.8694463    46514.44    24881.4    1.1954843   37659.68   31501.61

                       366.55     613.54 0.91621894        2068.3    2257.43    3.8745313     392.8     101.38    0.839885      525.81     626.05 0.92086303       1012.36    1099.36    1.0742283    557.17     518.67
Molecular Medicine




                      3106.11    2824.86    1.4124501     6622.71    4688.81    0.8810662   1488.72    1689.68    1.5374997    1661.33    1080.54    1.0399101     8951.13     8607.6    1.3305587   3305.64     2484.4
                                            0.9546963      397.02     415.86    1.474119     107.08      72.64                                       1.0659394      506.14     474.83 0.47951275       76.77      160.1
                      1441.67    2142.64    0.5783629     1046.86    1810.04 0.118965104     521.75    4385.74 0.89197063       820.39     919.75    0.7019159      641.86     914.44    0.7604071    396.75     521.76

                       1087.8    1111.44    0.9735737     1395.54    1433.42    2.0801466   1527.93     734.53    1.1717113     619.39     528.62    1.1944234     4377.61    3665.04    0.7945645   1969.94    2479.27
                       300.46     212.25 0.74795294        601.96     804.81    0.6446966    642.15     996.05 0.66057754        183.7     278.09    1.1974784      1322.1    1104.07    1.0333091    512.17     495.66
                      3488.98      3654     1.0242057     2045.39    1997.05 0.96084666     4882.11    5081.05    1.6465497    1326.23     805.46 0.69129544       3200.85    4630.22 0.92255753     1473.02    1596.67
                       340.17     344.47    0.8624022      605.07     701.61 0.92025423       321.5     349.36    2.2805681      449.5      197.1    0.76460844     586.47     767.02 0.78294283       146.7     187.37
                                            0.93242395      501.7     538.06    1.3279375    123.87      93.28                                       0.61776286     274.54     444.41
                      2208.68    2566.73    0.8015063     3853.61    4807.96    0.6825066    608.83     892.05 0.94138736       333.43     354.19     0.721233     3038.23    4212.55    1.1618677   3382.65    2911.39
                     51387.94      64385    2.1664836    130612.21   60287.65 0.53361404    36030.61   67521.85   0.9158745   57103.74    62348.87   0.6113732    39550.57    64691.37   1.0390319   32639.23   31413.12
                      9644.25    8466.69    0.9192854     6902.62    7508.68    0.5856283   1414.14    2414.74    1.7967359    1901.27    1058.18    2.0125713    10346.81    5141.09    0.9767763   2764.57     2830.3
                                           0.8322872      306.29     368.01 0.31979597       80.87      252.88                                       1.0321515     583.95     565.76    0.8795194    230.61      262.2




                                                                                                                                                                                                                    UNCORRECTED PROOF
                     15177.97   19089.13 0.75362736     26413.17    35048.05   2.112759    16505.55    7812.32    0.9882572    25484.17   25786.98 0.99780095     22890.97   22941.42   1.0522387   32803.13   31174.61
                     1173.12    1409.43    0.8784402     5103.43    5809.65    0.8378671   3663.13     4371.97    1.0473303    3757.36    3587.56    1.0224553    9248.66    9045.54    1.2115622    3710.7    3062.74
                     2058.06    1655.75    1.0514385     1238.91     1178.3    0.917053     342.18      373.13    2.0922656     480.97     229.88    0.6434755     569.36     884.82    1.1269026    851.42     755.54
                     9737.02    11108.85   1.2850525    14323.26    11146.05   0.9626983   3863.52     4013.22    0.6819164    1126.56    1652.05    1.2167904    10613.71   8722.71 0.91364723     6320.42    6917.79
www.molmed.org



                     8735.46     2849.3 0.76558095        2918.9    3812.66    0.7672142    844.58     1100.84    2.2222722    1732.15     779.45    0.6418418    1293.26    2014.92    1.0598406     1139     1074.69
                      9733.2    12766.95   1.3209708     6027.92    4563.25 0.97123665     3031.89     3121.68    0.9334143    2053.11    2199.57 0.87377197      12674.84   14505.89   1.2435503   7201.81    5791.33

                     14440.78   24458.71   1.1141225    28837.27    25883.39   0.3584935   8394.85    23417.02 0.44238883      14391.66   32531.7 0.58739656      44712.15   76119.19 0.80338776    22491.9    27996.32
                     3258.62    3610.89    0.8339315     1958.73    2348.79    0.5292008    653.69     1235.24 0.62455446       238.28     381.52    1.1312766    8322.35     7356.6    1.0532298   4291.88    4074.97
                     46954.17   42525.08   1.8701425    62489.95    33414.54   0.4402627   13503.21    30670.8     1.019233    16384.67   16075.49   0.5190286    13490.4    25991.63   0.8116464   12502.95   15404.43
                      372.64       498     0.66888285     560.37     837.77    0.646076     100.93      156.22                                       1.0854833     363.93     335.27 0.64056087      273.18     426.47
                      2083.3    2494.29 0.88930476       2217.01    2492.97 0.55963504      1108.9     1981.47      0.79641    2074.68    2605.04      0.98576    2155.66     2186.8    1.1836209   2799.37    2365.09

                     28173.32   24961.1    1.0315171    17854.91    17309.37   1.8844299   6449.97     3422.77 0.88537806      8811.77    9952.55 0.75189537      39252.36   52204.55   1.1504616   17447.28   15165.46
                     1056.03    1053.47    0.8802449     1939.03    2202.83 0.77970475      199.62      256.02 0.31540453        165.6     525.04    0.4990045    1293.24    2591.64 0.66463625      688.51    1035.92
                      280.22      67.28    0.98335814      408.9     415.82    0.6196989     94.25      152.09                                       1.5891802    1016.98     639.94    0.9271412    362.54     391.03
                     13342.91   11020.75    3.259851    25105.84    7701.53    1.5637773   25587.76   16362.79    1.9410098    24926.7    12842.13   2.1292853    17316.71   8132.64    1.3126811   8401.71    6400.42
                     42137.98   43596.51   0.7684342     8563.27    11143.79    3.20231    14103.39    4404.13    0.9531722     6292.7    6601.85    1.6561918    31217.23   18848.8    1.2606055   9313.24    7387.91
                     5308.47    5428.86 0.63765615       2445.66    3835.39    1.0734859   2587.09     2409.99 0.57698566      1195.67    2072.27      1.64119     5225.5    3183.97    1.0440776   1326.01    1270.03
                     89588.32     64385    2.0599587    127033.79   61668.12   1.833036    29921.25   16323.33    0.9792129    62745.28   64077.26   1.0143962    65622.68   64691.37   0.8572959   55393.95   64614.74
                     15809.15   18578.01   1.7578031    14831.99     8437.8    0.9428605   5107.73     5417.27    0.9019361    2186.23    2423.93    0.7436553    47060.91   63283.23   0.7365244   6335.48    8601.86
                     63348.25     64385    0.9402111    54307.42    57760.88 0.55146384    59566.5    108015.24   0.9718712    41849.58   43060.83   1.1901549    76992.75   64691.37   0.8371569   41929.18   50085.21
                     41267.29   43576.09   2.0037143    27901.66    13924.97   0.7504602   4940.88      6583.8    1.1057155    5254.88    4752.47    0.6465571    51542.12   79717.82 0.89630026     7842.6    8749.97
                     18839.33   19329.94   1.3267598    10572.18    7968.42    1.3760386   14927.5    10848.17    1.2564983    6760.74    5380.62    1.4386287    18619.25   12942.36   1.2659656    9337.8    7376.03
                      2177.6    1621.43    0.7202216     1620.16    2249.53    0.6998306   2602.67       3719     0.70621127   1054.79    1493.59    1.2940679    4239.03    3275.74    0.7991954   1388.69    1737.61

                     5217.04    5936.35    0.8161694     5592.05    6851.58    1.4409549   1708.67     1185.79 0.56451094      1249.02    2212.57    1.4139395    5037.47    3562.72    1.145113    1551.09    1354.53
Molecular Medicine




                      2372.7    3149.34    0.9912481     3002.54    3029.05    1.2575858    654.02      520.06 0.85015845       944.22    1110.64    1.1624753    3552.42    3055.91    1.0033349    776.24     773.66
                     2373.04    2607.31    0.8824273      2620.5    2969.65    0.5787406    856.05     1479.16    0.6049167    1647.92    2724.21    0.8009512    3850.06    4806.86 0.90604544     2102.56    2320.59
                     1303.44    1054.25    1.0366641     1088.29     1049.8    1.2056363    596.79        495     1.3092383     610.38     466.21    0.9880287     448.98     454.42    0.8115821    427.72     527.02
                     1800.03    1474.55    1.8045797     1715.65     950.72    0.809351     894.09      1104.7    1.0210068     1016.3     995.39    0.7635739     266.64      349.2    0.8227284    637.96     775.42
                      1082.3     823.71    0.7532567      758.07    1006.39 0.93488795      818.27      875.26    1.7155356     809.75     472.01     1.166184    1002.65     859.77 0.62895316      116.74     185.61
                     1268.04    1737.78 0.80559987       1861.83    2311.11    2.0410233    835.35      409.28    1.2205986     776.02     635.77    0.8476274     221.68     261.53    0.9184839    910.19     990.97
                     4417.84    7068.51      0.60453     2828.88    4679.47    1.533547    6480.11     4225.57    0.8012126    5506.55    6872.77    1.8563234    2860.91    1541.17 0.92546695     2461.15    2659.36
                     38511.05   30182.37   1.2034634    27687.42    23006.45   1.1207981   15895.17   14182.01    1.0238085    9081.99    8870.79     1.187585    20293.69   17088.2    0.9906605   19991.44   20179.91
                     9858.77    14254.88   1.1594604     9466.09    8164.22    1.0675389   2435.43     2281.35 0.40769905       3604.5    8841.08     1.847408    6078.97    3290.54    1.4391532   10864.57   7549.28
                      274.29     220.15 0.75130564        720.72     959.29    1.2439566    257.81      207.25           2      224.66     112.33    0.79862726    329.29     412.32    0.7734031    270.49     349.74
                     37090.01   44244.1    1.0955713    42794.99    39061.8    1.415716    28172.38   19899.74 0.72941965      45740.35   62707.87   1.0643781    43796.35   41147.36   1.1535622   60541.5    52482.22
                      381.27     361.91    0.7225571      744.27    1030.05    0.4080433    191.56      469.46                                       1.0414246    2228.43    2139.79    0.8731226    1117.3    1279.66
                     7565.07    6170.41    1.7564744    10577.98   6022.28    1.3842258   6322.77    4567.73    1.0324548    8316.94     8055.5    1.1378757    9346.83    8214.28 0.98127884      8370.75    8530.45




                                                                                                                                                                                                                   UNCORRECTED PROOF
                      2439.5    2026.19    1.1577007     3045.1     2630.3    1.2964443   1517.89    1170.81    1.5459913    1887.98    1221.21    1.4011472    2740.49    1955.89    1.2087803    4027.68    3332.02
                                           1.4037985    3027.53    2156.67                                      0.30836383    207.35     672.42 0.78529084      1496.89    1906.16 0.98502356        230.2      233.7
                     9261.11    9323.02    0.8543969    5467.73    6399.52 0.42144573      3519.7    8351.49    0.7149907    1996.64    2792.54      1.26331    26057.93   20626.71   0.8566289    2264.37    2643.35

                      250.49     272.71    1.0448372    1798.98    1721.78 0.76986396      388.15     504.18    1.4022305     412.41     294.11     1.279721    4712.88    3682.74    1.2961136     709.35     547.29
                      295.44      70.69    0.80018544    811.38    1013.99    1.6405113    818.73     499.07     1.817888     371.14     204.16    0.8727031    1016.83    1165.15    0.8911587     845.87     949.18
www.molmed.org




                     26888.89   27022.09   0.9823301    10748.95   10942.3    1.6100065   7038.32    4371.61    1.0868958    4850.74    4462.93    1.1854165    21331.9    17995.28   1.0009432    9688.56    9679.43
                      241.33     125.11    0.9748613    1104.44    1132.92    0.6716586    394.23     586.95    0.8189157     360.11     439.74    0.9567049    1478.09    1544.98    1.1285204    1418.11    1256.61
                      497.17     755.32 0.88438517       701.68     793.41    0.925486     287.53     310.68    1.0066832     254.56     252.87 0.68973285       327.43     474.72    1.1423081     231.82     202.94
                     1116.29    1187.32 0.90674996      1243.68    1371.58    1.8325216    553.22     301.89 0.34970507        92.49     264.48    0.5961513    2768.58    4644.09    1.2323853    1152.12     934.87
                      198.11     251.38    1.4352487     331.93     231.27     1.23653      205.4     166.11                                       0.9548324     972.64    1018.65    1.1417159     230.09     201.53
                                           0.8550925    1706.91    1996.17    0.9244128    271.99     294.23    1.1700845      242.5     207.25 0.83817387      2941.94    3509.94 0.56445104       444.81     788.04
                      120.19      64.45    1.0544095     334.29     317.04    0.4460662    144.86     324.75    1.4182954     156.75     110.52    0.6266865     239.67     382.44 0.29121977       104.81      359.9
                                           1.0558624     728.26     689.73    4.1619687     98.93      23.77                                       1.1829814    1561.63    1320.08 0.99823374      2543.24    2547.74
                      381.59     484.64    0.7456837    1180.38    1582.95    0.4602063    248.99     541.04                                       0.96788484   1771.51    1830.29    1.0669943     525.58     492.58
                      282.03     329.71    0.8500541     329.94     388.14 0.38193756      150.64     394.41    1.0769767     201.05     186.68 0.90174663       212.19     235.31 0.52856183       141.94     268.54
                     2779.63    3368.65    1.6258098    4223.87    2598.01    0.4475904    605.46    1352.71 0.62573636      1066.48    1704.36    0.7860258    1614.89     2054.5    0.8101181    1493.72    1843.83
                     1484.78    1889.74 0.88522506      1760.27     1988.5    1.1188915   1041.33     930.68 0.37257472       170.71     458.19    1.0733614    1635.47    1523.69    0.8796079    1105.72    1257.06
                      181.01      78.33    0.6987489     444.02     635.45    1.7250812    153.86      89.19     7.723955     131.23      16.99    1.1269168     177.85     157.82 0.87151736       678.79     778.86
                      2289.9    3178.48    1.0730294      663.1     617.97 0.35722035      592.85    1659.62 0.99889493       732.16     732.97    0.8769343     614.88     701.17    1.2380753     913.65     737.96
                                           1.0190017     467.09     458.38    0.6283696    144.99     230.74                                       1.6229595     831.15     512.12 0.59399325       107.59     181.13
                      595.07     591.05    0.6570942     578.67     880.65 0.89923155      380.33     422.95                                        1.157397    1290.22    1114.76    0.8052626    1248.93    1550.96
                       2672     3902.95    0.5583484     428.27     767.03    0.5177526    260.88     503.87                                       1.2069674    1098.98     910.53    1.0740651     176.34     164.18
                       170.6      50.45    1.0057272     333.65     331.75 0.36160293      300.04     829.75    0.9925171     157.84     159.03 0.83538496       394.97      472.8    0.9643735      97.99     101.61
                     36156.56   32481.38   1.1108283    7030.11    6328.71    1.0340008   5596.86    5412.82    1.1445693    4341.42    3793.06    1.3171757    24094.99   18292.92   1.2859249    6011.12    4674.55
                      434.21     261.59    1.1687269    4622.49    3955.15    1.3878047    416.05     299.79     1.971983     427.94     217.01 0.92128235      12796.28   13889.64   1.4988205    1035.64     690.97

                       57.06     226.53    0.7604144     772.14    1015.42    1.2274325    342.11     278.72                                       1.1122334    2273.75    2044.31    0.9333327    1041.87    1116.29
Molecular Medicine




                     29362.82   32977.91   0.8953665    39153.39   43728.9 0.91064596     12073.59   13258.27   1.1406221    21267.32   18645.37    1.159913    18447.73   15904.41   1.2517098    39758.52   31763.37

                      696.03     793.38 0.64205515       842.28    1311.85    1.1812917    650.75     550.88                                       0.9941911    1174.09    1180.95 0.91047025      1051.32     1154.7
                     7742.72    9697.43 0.71378905      9111.81    12765.41   0.4523673    2928.3    6473.28 0.42747062      3250.82    7604.78    0.9097252    13999.57   15388.79   1.0666288    6467.44    6063.44
                      534.39     520.78    0.7851042     567.12     722.35 0.38089794      239.84     629.67 0.58195984       103.81     178.38    0.8055478     486.43     603.85    1.2232608     218.56     178.67
                     4554.99    5152.39    1.1084206    2876.03    2594.71    2.3378086    983.82     420.83    0.7876388    1078.12     1368.8 0.62712383      2776.76    4427.77    0.8977392    2404.28    2678.15

                     2110.27    2794.09 0.67633635      2643.65    3908.78    0.616758    1827.75    2963.48 0.26433015       671.47    2540.27    0.4362409    3554.67    8148.41 0.60419565      3081.38    5099.97

                     16733.39   19509.09 0.56193006     5501.52     9790.4 0.65745527     2236.15    3401.22    1.3009875    5341.62    4105.82 0.58926535      3233.24     5486.9 0.81303877      7869.28    9678.85

                     46848.85   63268.16   1.3674465    66711.03   48785.11   1.0005125   32370.39   32353.81    0.626113    27289.09   43584.93 0.56645375     36644.67   64691.37   0.9220915    36832.9    39944.95

                      457.56      384.1     0.913862     585.95     641.18    1.1954153    222.67     186.27    0.8238913    1017.72    1235.26 0.75643724       381.32      504.1    0.57030267    285.83     501.19
                     9775.22    10631.43   1.7868536    9401.03    5261.22    1.0793377   4731.73    4383.92    0.6054527    5898.69    9742.61    0.5953237    35745.38   60043.6 0.56977195     9770.78    17148.58




                                                                                                                                                                                                                  UNCORRECTED PROOF
                     93768.12     64385    1.2538086    81326.35   64863.45   3.5193748   72179.14   20509.08   1.3302726    82927.05   62338.39   1.5623136    101068.2   64691.37   1.2602589   65359.12   51861.66

                     18063.72   26067.32   1.7599459    38689.86   21983.55   1.2544714   3834.38    3056.57    0.6785817    9470.15    13955.8    0.5964809    15215.75   25509.2 0.64827496     5539.84    8545.51
                      180.41      99.13    0.7054039     732.83    1038.88 0.81444716      201.03     246.83 0.06999528        13.36     190.87    1.1387597    2712.48    2381.96    0.7863836    277.79     353.25
www.molmed.org




                      721.07     877.91 0.61298686       1389.2    2266.28 0.87825304      597.66     680.51    0.7061192     631.44     894.24    0.8350885    2015.72    2413.78    0.8292838   1180.56    1423.59

                     49149.21   46691.17   1.5255198    45494.33   29822.18 0.57317847    8400.75    14656.43   0.5834968    8817.36    15111.24   0.8051311    38085.62   47303.63   0.7084199   6861.55    9685.71

                     1075.85     769.53    0.4127491    1524.46    3693.43    1.5693903   2239.52      1427     1.4415015     828.33     574.63    0.7288143    3909.87     5364.7 0.33056745     1605.89    4857.98
                      987.92      953.7    0.75746024   2305.83    3044.16    1.9178764   1142.69     595.81    0.8255526     755.62     915.29    1.1355121    3124.35    2751.49 0.95820874     1125.33    1174.41
                     6865.74    8427.15     1.130343    9808.98    8677.88    1.2018024   3178.07    2644.42    0.4907102    1863.84    3798.25    0.5390642    15584.54   28910.36 0.73388577    3975.87    5417.56
                     1448.11    1575.97    1.0212405     781.78     765.52    0.7537283    557.97     740.28    0.9982048     517.13     518.06 0.95898634       659.61     687.82    0.9039116   1036.66    1146.86

                     2170.79    2316.84    0.9643963    3180.55    3297.97    1.5517255   1255.92     809.37      1.21764      910.6     747.84 0.74667406      8179.21    10954.19   1.0986282    757.57     689.56

                                           0.77892095    457.25     587.03                                                                         0.85156924    376.07     441.62

                     81086.42     64385    1.3906422    90201.84   64863.45   0.7924606   17318.61   21854.22    1.351607    27758.68   20537.54   1.0836831    60324.5    55666.18   1.0140189   20263.78   19983.63

                     8881.01    9056.12    1.6723648    7652.39    4575.79    0.8923248    2397.9    2687.25    1.6643769    4051.06    2433.98    2.0324583    2944.89    1448.93 0.83800757     1561.56    1863.42
                      108.99     319.22 0.92328984       496.97     538.26    2.6678383    197.34      73.97    0.55654347    175.89     316.04    0.8236863     713.65     866.41    1.1007862    628.67     571.11
                      366.63     367.01 0.88649243      1888.61    2130.43 0.72798234      681.77     936.52    1.4348769     793.86     553.26    1.1489398    2648.49    2305.16    1.0225513    921.83      901.5
                     24328.03   17336.08   1.4573135    12431.38   8530.34    1.0612949   7559.53    7122.93    1.7622199    4233.61    2402.43    1.9018426    17702.14   9307.89    1.219578    7295.26    5981.79
                     29789.43   29365.94   1.0557874    23421.41   22183.83   1.4862407   9623.78    6475.25    1.1362584    5999.83    5280.34     1.345214    36597.34   27205.59   0.7457766   24483.07   32828.96
                      1011.4     842.19     0.540742     567.99    1050.39    0.582212     390.28     670.34                                       0.9864215    2538.97    2573.92    0.8022986   2559.87    3190.67
                     4915.74    9234.02    1.0442083    5631.28    5392.87     1.28315    4679.25    3646.69     0.809783    4452.77    5498.72    0.5758539    5041.56    8754.93 0.77171624      2591.4    3357.97
                     5421.55    4515.79    1.0763342    9617.66    8935.57    1.3494184   6843.13    5071.17    1.0155677    4924.01    4848.53     0.970355    12787.9    13178.58 0.98512447    10819.73   10983.11
                     5875.41    5835.41    0.9696654    2415.65    2491.22    0.7743707   1081.85    1397.07    1.1831734    1260.34    1065.22 0.95111865      4231.86    4449.35    0.9022825   1259.83    1396.27
                     57372.62   37796.52   2.5505402    51345.49   20131.22   1.1188964   14878.58   13297.55   0.7191602    15270.41   21233.67 0.52450067     21699.31   41371.37   1.2874446   12783.72   9929.53
Molecular Medicine




                      703.53     739.62 0.67891115       701.03    1032.58    0.6881915    372.58     541.39    0.4811368       57.9     120.34    0.6754828    1927.72    2853.84 0.98128337      465.04     473.91
                     5574.56    6704.82    1.2704762    4167.34    3280.14 0.67308605      865.03    1285.17 0.58935255      1444.45    2450.91 0.56934696      2059.18    3616.74 0.58610773      792.57    1352.26

                     2891.87     3667.1    1.2305092    1706.95    1387.19 0.51909363      623.12     1200.4 0.47232115       624.47    1322.13    0.7814742    4699.02    6013.02 0.48633757     1219.01    2506.51

                     19355.21   16214.91   1.4105419    14692.84   10416.45   1.0000976   7987.26    7986.48 0.92976594      5846.61    6288.26    0.5083874    4087.77    8040.66    0.9775946   6096.71    6236.44

                     49534.04     64385    0.6682193    43343.01   64863.45 0.46205556    19655.11   42538.41   1.0478537    19351.47   18467.72   1.5451592      37022    23959.99   1.8133767   19424.31   10711.68
                     5447.86    4874.41    0.7784133    2746.32     3528.1    1.3010775    544.54     418.53    0.5914956     586.74     991.96    1.2044523    3668.87    3046.09    0.9824466   6732.53    6852.82
                      920.03      850.9    1.1707579    2827.72    2415.29    1.5012159    605.02     403.02    0.9477464     943.69     995.72 0.66370183      1405.09    2117.05    1.0713403    754.62     704.37
                      120.43     132.34 0.61383235        276.2     449.96 0.09503744       67.89     714.35    1.4706196     110.37      75.05    0.9161449    1088.71    1188.36 0.48160613      188.91     392.25
                       258.7     276.85    0.5395055     593.92    1100.86 0.24062744      198.97     826.88 0.64775485       168.06     259.45 0.78434515       651.83     831.05    0.5041119    461.58     915.63
                      810.88     689.67     0.987756    1377.89    1394.97    0.8291436    857.89    1034.67                                       1.0448402    2318.49    2218.99    1.0284365    900.17     875.28
                     6666.88    5944.66     1.511945    7058.47    4668.47    1.0816063   4119.47    3808.66    0.7547193    3866.88     5123.6     2.452841    11189.91   4562.02    3.0305634   6448.16    2127.71
                     2912.38    2722.91    1.3686621    3463.29    2530.42    1.380747    9628.17    6973.16    0.7348075     2560.4    3484.45     2.304189    5260.21    2282.89    2.494065    6713.15    2691.65
                     3311.08    4926.69 0.97719884      5157.89    5278.24    1.0646257     1855.27    1742.65 0.45105916       446.95     990.89    2.0428958     6083.09    2977.68    1.6810977    2014.14    1198.11




                                                                                                                                                                                                                      UNCORRECTED PROOF
                     10887.76   10529.33   1.1526711    11804.7    10241.17   0.8602401     6163.56    7164.93 0.99107945      7257.06    7322.38    2.3382733    33146.59    14175.67   1.9734802    11181.72   5665.99
                      381.08     223.07    1.2342458    1429.38     1158.1    3.6177354      567.08     156.75 0.43263596       384.86     889.57     2.826833     3023.92    1069.72      2.08242    1687.26     810.24
                     3431.64    3402.02 0.98724115      5198.21    5265.39    2.0043178     6382.69    3184.47    1.2714113    7782.55    6121.19    0.9097035    38754.68    42601.44   1.1140418    12592.65   11303.57
                     1317.09    1338.76    2.2236986    1697.06     763.17 0.56172836        465.42     828.55    1.1929024    1148.61     962.87    0.6318373      790.22    1250.67    0.9358667    1032.86    1103.64
                      180.97     241.78 0.97388166       579.07      594.6    0.69075495     220.71     319.52    0.906243      241.84     266.86     0.857608      281.81      328.6    0.7871161     542.26     688.92
www.molmed.org



                     84306.33     64385    1.5855118   47706.51    30089.03   1.2810551    14582.84    11383.46   2.0966427   24006.54    11449.99   1.4690834    43901.65    29883.7    0.9443049    20460.98   21667.77
                     2355.54    3259.06 0.87410164       1523.9    1743.39 0.96697026       1605.48    1660.32    1.5890164    1939.76    1220.73    1.1617382      5056.5    4352.53    0.8746351     2211.2    2528.14
                     7258.71    6568.98    1.3729423   17364.96    12647.99 0.34802935      5827.96    16745.6    1.3170478    8822.18    6698.45    0.8480241     7826.83    9229.49    1.4526825    8239.92    5672.21
                     14811.1    5894.39    1.4307938   11601.52    8108.45     5.446433      18201     3341.82    1.8862925    4587.52    2432.03    1.0367663    46450.82    44803.56   1.0453905    5384.65    5150.85

                      229.67     363.24 0.66760427       386.87     579.49                                        1.0741102      98.99      92.16    1.5361233     1103.72     718.51    0.8403004     511.39     608.58

                     1259.01    1045.19    0.7787526     753.56     967.65    0.7197079      329.18     457.38                                       0.8947937     1001.99     1119.8    0.89940405    760.68     845.76

                       52.46       41.1    0.865202      473.75     547.56                                             1.5       30.87      20.58    0.46649256      89.31     191.45 0.41597354       148.54     357.09

                     7983.08    5777.01    1.3965951    8731.82    6252.22    1.1821585     6626.27    5605.23    1.7294105    7949.08    4596.41    1.3937224    27571.02    19782.29   1.4299792    11068.64   7740.42
                     62372.21   55120.04   0.8623434   35936.76    41673.38   0.6265831    17885.25    28544.1 0.89900255      6567.24    7305.03    1.3882222    50445.76    36338.39   1.0943521    24531.6    22416.55
                     75457.19     64385     1.36273    42253.34    31006.39   1.3978328    27846.66    19921.31   1.243444    23403.48    18821.5     1.358829    24463.84    18003.62   1.4603268    19541.45   13381.56
                     66205.93   53934.26   1.0540959   48902.29    46392.64 0.98442954     62622.34    63612.82   0.8365238   21094.31    25216.63   0.6724244    28214.43    41959.26   1.1255302    43114.88   38306.28
                     68947.83     64385    1.2856691   39630.71    30824.97 0.53446454     19857.67    37154.33   1.3028653   25595.49    19645.54   1.0484867    67828.04    64691.37    1.181035    21706.81   18379.48

                     4363.66    3418.27    1.1039804    3207.03    2904.97    1.9766157     2514.69    1272.22    1.4365256    1194.04      831.2    1.8831879     6077.65    3227.32    1.0320418    2572.56    2492.69
                      116.86      17.83    0.7844324     482.12     614.61    1.5768217      155.38      98.54                                       0.90191734     268.14      297.3    0.60809845     85.45     140.52
                     17879.13   23532.28   1.0170864   15578.53    15316.82   1.0033082     7524.32    7499.51 0.43328327      6149.23    14192.17   1.1208287    57200.34    51033.97   0.9919877    12306.6      12406

                     4819.01    2883.31    1.2233764    3079.74    2517.41    3.0579174     2348.45     767.99    1.9208066     745.83     388.29     1.996726     6922.29    3466.82    0.8067607    1760.82    2182.58
                     99503.15     64385    2.0020146   129857.57   64863.45   1.6243286    104115.73   64097.7    1.9439001   124977.63   64292.21   2.8068068    181576.19   64691.37   1.2964202    83767.85   64614.74
                     71617.01     64385    1.3500183   87566.84    64863.45   1.2334287    65395.07    53018.93   2.4717612   139754.44   56540.43   1.7127914    110802.83   64691.37   1.3321829    81196.11   60949.67
                     26391.24   26921.51   1.4804257   47895.65    32352.62   1.7118431    37534.49    21926.36   1.6671509   58876.85    35315.85   1.6310757    105516.52   64691.37   1.2304648    77292.08   62815.35
                      122686      64385    3.2174158   208692.69   64863.45   1.1683198    74886.61    64097.7    1.4059347   90390.65    64292.21   1.5890222    102796.02   64691.37   1.3631085    88076.9    64614.74
Molecular Medicine




                      290.45     317.24    0.6840644     485.33     709.48    0.4644215      236.92     510.14 0.10536523        24.45     232.05    1.8758699     2821.89    1504.31    0.7519217     465.62     619.24
                     62832.85   31787.05   1.6201028   29795.78    18391.29   1.6401349    32867.29    20039.38   1.3585707    9622.05    7082.48    1.3115616    84846.72    64691.37    0.805045    35226.87   43757.64
                     5275.52    5791.03    1.1153924    3728.11    3342.42    1.8760602     1203.08     641.28     1.13131     1834.34    1621.43    0.9013415     2237.49     2482.4    1.0225079    1426.46    1395.06
                      426.78     208.06 0.69372016       528.92     762.44 0.98995364        349.81     353.36                                       1.0186375      616.51     605.23     5.522055     121.43      21.99
                      524.83     385.97    0.9171362    2200.65    2399.48    1.2850869      792.86     616.97    1.2581053      308.5     245.21    1.3411435     9423.41     7026.4    0.7887077     728.34     923.46
                     3234.58    4929.98 0.67945397      3316.68    4881.39    1.1381693     3559.26    3127.18 0.77214766      3397.55    4400.13    0.7407948    10073.49    13598.22   1.0552673    3270.59     3099.3
                     3177.29    3405.85 0.81255513      1087.02    1337.78     2.608747      682.37     261.57 0.31114513         97.6     313.68     1.041207    30085.52    28894.85    0.952069    2798.54    2939.43
                       72.93     189.58 0.67522705       344.96     510.88    0.3679411      205.37     558.16    1.578086      177.44     112.44    0.8605195      749.96     871.52 0.98579293       315.02     319.56
                     2918.72     2869.5 0.75667423      2190.08    2894.35    1.0140853     1330.49    1312.01    1.1973902     803.82     671.31    0.8324375     1400.06    1681.88    0.9762923    1511.73    1548.44
                     5952.94    7481.22    1.1940404    2119.78     1775.3    0.4284878      871.24    2033.29    0.9558346    1122.58    1174.45 0.79100597         1728     2184.56 0.93173724      3876.94    4160.98
                     19291.94   12388.6    1.1338222    4802.86    4235.99 0.42071706       6289.72      14950    1.5634723    7964.39    5094.04    1.5428388     4403.74    2854.31    1.2808111    3605.56    2815.06
                     10538.18   12215.67 0.99972016    7573.76    7575.88 0.56528383      3716.47    6574.52 0.93716574      3327.36    3550.45     1.109628      4945.9    4457.26    1.1149355   5516.79    4948.08




                                                                                                                                                                                                                   UNCORRECTED PROOF
                     7496.97    5974.28    1.1954435   4552.93    3808.57 0.47760162      4302.88    9009.35     1.216282    3376.18    2775.82    0.9780031     2714.33    2775.38    1.1835508   2983.14     2520.5
                     2182.75    2094.55    0.7782663   1633.76    2099.23    0.8472696     245.92     290.25    1.0681345     267.29     250.24 0.50559866       3007.22    5947.84    0.6100183   1822.93    2988.32

                     28825.44   30401.23   1.0358969   14532.39   14028.8    1.1192647    11167.8     9977.8 0.96266645      13000.3    13504.47    0.638235    10968.08    17185.02   1.0081869   16134.66   16003.64
www.molmed.org



                     11190.13   9328.45    1.2110868   4580.79    3782.38    1.0395961    9605.39    9239.54    1.2081652    5808.17    4807.43    1.3111145    68172.62    51995.93   1.0726032   15988.32   14906.09

                      796.74     667.18    0.7917403   1196.09    1510.71    1.1946653     573.75     480.26    1.0720923     430.37     401.43     0.834815     2097.74    2512.82 0.92017066      491.73     534.39
                     19660.56   17472.66   1.4940379   8923.44     5972.7    1.9763052    15959.14   8075.24    1.1358014     5307.6      4673     1.5350126    21860.59    14241.31   0.7215924   7472.09      10355

                      260.67     155.93    0.7686429    788.52    1025.86    1.0209448     238.36     233.47                                       0.88911974     731.55     822.78    1.1517763    428.91     372.39
                       296.3     333.52    1.0532482    762.52     723.97    1.6554047     619.32     374.12    2.2424471     207.83      92.68    0.90111035    1189.79    1320.36    1.0631329    863.03     811.78
                      2492.3    2515.77    1.0172276   1372.23    1348.99 0.58810383      1002.67    1704.92    1.0882193    1126.59    1035.26    0.7272596      250.97     345.09    0.8099377    586.97     724.71

                      631.22      751.7    0.9434345   1125.64    1193.13    1.2805662     666.65     520.59 0.44434133       172.32     387.81    0.7790654      964.07    1237.47 0.85440934      935.92     1095.4

                     2964.75    2458.97    0.9405215   2769.61    2944.76    0.7821345    1645.04    2103.27    0.9106125     947.72    1040.75    1.3986936     3672.27     2625.5    1.4459742   3541.48     2449.2

                      188.78     265.31 0.58166414      505.85     869.66 0.46904415       306.98     654.48                                       1.0935261      898.78     821.91    0.8490611    140.18      165.1

                     1183.83    1080.84 0.91151685     3096.76    3397.37    0.8746721     283.42     324.03                                       1.1115271     7584.75    6823.72    1.0198559   1649.78    1617.66

                     41847.89   19860.26   2.5106368   15743.35   6270.66    1.8256682    12159.37   6660.23    2.1925552    11159.36   5089.66    1.7788364    48586.76    27313.79   0.9814489   12915.73   13159.86

                       960.7     627.98    0.9668566    2437.9    2521.47 0.56957513      1976.87    3470.78    1.1902459     856.62      719.7    1.5107068     6336.01    4194.07    1.1236206   1438.74    1280.45
                     81137.65     64385    1.6117165   89671.16   55637.05   2.0461965    33394.64   16320.35   1.3932205    52335.33   37564.28   1.2202953    78942.58    64691.37 0.93865997    22755.7    24242.75
                     44966.56     64385    2.1000862   90051.36   42879.84    0.877016    22558.65   25722.05   1.2996242    37380.04   28762.19 0.91465336     59170.18    64691.37   1.0859933   38557.14   35504.03
                     27258.83     40561    0.9997344   20171.22   20176.58   1.1845717    7607.77    6422.38    0.8299973    13402.78   16147.98   1.0024922     6987.23    6969.86    1.4783571   23913.83   16175.95
                     44120.81   50326.97   1.5403659   9325.19    6053.88    1.6872003    4119.03    2441.34 0.77307534      1734.41    2243.52    1.1275895    14516.97    12874.34   0.950341    6211.21    6535.77

                      805.04     991.44    0.7822544   1357.36    1735.19    0.6194807     542.82     876.25 0.78189605       583.92      746.8    1.3687525     1284.93     938.76    0.7343078    666.12     907.14

                     12568.39   12737.91   1.1080112   5193.26    4687.01    1.4576472    3800.48    2607.27    1.0637823    3414.22    3209.51    1.0933707     9131.93    8352.09    1.1184525   3940.89    3523.52
Molecular Medicine




                     77139.75     64385    1.0623885   66598.32   62687.35   0.7937581    15628.74   19689.55 0.85503525     26577.59   31083.62   1.2430676    37660.46    30296.39   1.258687      8018     6370.13

                     43548.84   41686.95   1.9120573   47493.88   24839.15   0.9070942    40784.95   44962.2    1.1098754    42598.17   38381.04   1.4687967    52536.07    35768.1 0.90533966     18690.33   20644.55

                     3235.42    2869.39    1.349785     8708.8    6451.99    1.6946315     943.52     556.77    0.6897323     1017.5    1475.21    1.0593033    11991.25    11319.94   0.9817989   3577.96    3644.29

                     8684.79    7985.24 0.85615903     2977.37    3477.59    1.7036105    13305.13   7809.96     1.438149    15477.82   10762.32    2.122112    44808.82    21115.2    1.4229496   13113.89   9215.99
                      302.21     228.84    1.5640585   1199.93     767.19    0.9369493     205.22     219.03    1.0625129     256.99     241.87    1.3433722     2615.68     1947.1    1.1473079   1762.46    1536.17
                       95.07     170.74    0.9345723    648.21     693.59    0.8876102     181.25      204.2    0.33862284     72.34     213.63    0.6852104      190.79     278.44 0.31398892      111.24     354.28

                     1613.63    1887.84 0.89115614      993.14    1114.44    0.47961286    438.04     913.32     1.102132     172.66     156.66    0.9099634     1652.53    1816.04 0.97298855      794.27     816.32
                     4435.68    3521.75 0.87955487     2459.64    2796.46    0.9133806    2689.02    2944.03    1.2444016    1645.41    1322.25    1.3291407     7423.41    5585.12    1.3601553   3973.83     2921.6
                     24299.58   12368.22    3.44669    31876.68   9248.49     2.358984    22186.01    9404.9    2.7792366    9178.04    3302.36    1.9547939    104309.51   53360.87   1.1843104   21704.54   18326.73

                     37554.59   40662.05 0.91525483    32342.66   35337.33   2.5322127    18874.96   7453.94     0.939189    14629.7    15576.95   1.6007521    68973.23    43088.01   1.2746599   24073.06   18885.87
                      51828.7    43629.45   1.3513125   42510.47    31458.65 0.89748615    27238.57   30349.85   1.1630024   24444.39   21018.35   1.9371086    114780.12   59253.32   1.3466007    19202.47   14259.96




                                                                                                                                                                                                                    UNCORRECTED PROOF
                     15921.19    9891.48    1.4817717    8832.07    5960.48    1.0294833   6753.05    6559.65    1.9027003   4797.05    2521.18     2.464477    17898.93    7262.77    1.4044803    4728.52    3366.74
                     29715.08    36610.08   0.9236274     29055     31457.49   1.0247489   5079.65    4956.97    0.8844988   7667.57    8668.83    1.2112948    19719.83    16279.96   1.5641066    9837.73    6289.68
                      1122.65    1272.97    1.2391855    1390.49     1122.1    0.6783004    546.12     805.13    0.9294937   1374.87    1479.16    1.1753888     7784.13     6622.6    1.1617557    3369.01    2899.93
                      6386.86    13897.71   0.8416131   12247.28    14552.15   1.5428816   11086.9    7185.84 0.86359626     10157.68   11762.07   1.2922062     4016.81    3108.49 0.91179985      4443.52    4873.35
                       455.27     482.24 0.50915235       454.78     893.21 0.68940425      340.09     493.31    1.093442     313.96     287.13    0.9178642      705.81     768.97    0.6839957     243.01     355.28
www.molmed.org




                      11507.8    11412.63   1.0615292   14321.09      13491    0.6842753   6748.22    9861.85    0.9618107   13208.96   13733.43   1.0149802      696.52     686.24    1.1283407     497.35     440.78
                      3347.41    2195.17 0.90374166      6766.82    7487.56    1.577929    4235.84    2684.43     1.76573    4678.92    2649.85    2.2608728     9794.35    4332.11    1.1379117    2149.06     1888.6
                       411.51     230.35 0.48088416      1678.43     3490.3 0.55142474      461.73     837.34 0.84931576       321.5     378.54    1.1207284      995.33     888.11    1.0468738    1124.29    1073.95
                      1787.84    2126.59 0.83490604      1604.08    1921.27    0.2621498    610.29    2328.02    1.4173262     669.8     472.58    0.8526288      926.33    1086.44    1.1401345     994.87     872.59
                       3982.5    3107.65    0.7917782    3150.05    3978.45    0.6496017   2217.87     3414.2    0.7637307   1152.21    1508.66    1.1683406     6645.79    5688.23    1.0460788    2050.89    1960.55
                      1978.21    1939.28    1.1000257    1972.83    1793.44    0.6409111   1240.65    1935.76    1.1719261    1002.7      855.6    1.0481418     1110.37    1059.37     1.115384    1930.25    1730.57
                     47803.76    40534.71   1.195392    44262.39    37027.51   2.7462547   11918.69   4339.98    1.1549906   16875.22   14610.7    2.6094215    58622.66    22465.77   1.2525696    37504.9    29942.37
                       1168.8    1521.34    1.3306587     2782.9    2091.37    1.0723333    540.96     504.47    0.8306096    847.77    1020.66    0.5536749     1158.93    2093.16    1.0527503     1073.3    1019.52
                      4564.31    3989.23    0.9181719    4901.44    5338.26    1.4999487   1318.38     878.95 0.72318864     1414.34     1955.7     1.313614     3878.34    2952.42    1.2058033    2277.69    1888.94
                     35337.24    24782.27   2.1894212   45723.15    20883.67   2.200391    11029.9     5012.7    0.8637927   11810.88   13673.28   1.1820205    29647.69    25082.21 0.96184844     13476.41   14010.95
                        3110     4053.66 0.46477777       8212.2    17669.09   9.426796    46695.63    4953.5    5.9800606   15706.51   2626.48    5.4706626     8252.22    1508.45    1.0891519    1271.77    1167.67
                     53622.21    62162.85   1.3735962   63558.48    46271.59   9.456638    19910.1    2105.41    1.2863355   31813.79   24732.11   1.3464484    63698.53    47308.56   1.2566996    28392.01   22592.52
                      6834.29    4493.11    5.571399    23953.62    4299.39    1.8156953   27873.32   15351.32   3.0992837   27763.66   8958.09     6.311436    272966.34   43249.48   0.4074996     3922.2    9625.04
                       8428.6    7006.37    3.8920326   20348.87    5228.34    3.7402349   28595.89   7645.48    1.2318735   10505.06   8527.71    2.0931802      64693     30906.56   0.4871603    5507.24    11304.78
                     106546.25     64385    2.7945018   128236.92   45889.01   3.7277563   53179.05   14265.7    1.5144124   97364.92   64292.21   1.9867995    101264.19   50968.5     0.742554    43500.04   58581.65
                      19307.9    17393.91   1.9247228   31886.15    16566.62   2.0505054   17985.31   8771.16    1.6531905   32483.26   19648.83   1.5945022    10950.34    6867.56    0.9123836    13808.16   15134.16
                                            0.616628      257.51     417.61 0.10608991       18.64      175.7                                      0.84045124     330.02     392.67    1.0652914     121.88     114.41
                       635.63     337.27 0.84759134      1003.26    1183.66    2.352028     269.66     114.65                                       1.333051     2564.87    1924.06    1.2052219     524.38     435.09
                      2061.03    3842.47    1.4275064    5135.84    3597.77 0.50967085     1648.51    3234.46 0.41949266     1700.51    4053.73    1.3496974     2104.34    1559.12    0.6745021    1043.05     1546.4
                                            0.8342166     661.15     792.54 0.26919746      115.09     427.53                                      0.9610508      659.55     686.28 0.62877375       356.98     567.74
                      2306.27    2493.55    1.4464253    2613.17    1806.64 0.53206146     1030.47    1936.75    1.1908234     645.2     541.81 0.67521614       1178.34    1745.13 0.66982776       656.88     980.67
Molecular Medicine




                       240.95      446.4    1.3102572     856.62     653.78 0.45190364      241.19     533.72    1.0918299    273.82     250.79 0.89738894        495.61     552.28     1.257274     303.77     241.61
                     17027.79    17734.82   1.2012907    5802.39    4830.13    1.218905    11770.66   9656.75 0.70686233      3875.5    5482.68    1.1466116    18299.68    15959.79   1.0373653    7527.33     7256.2
                     47352.42    47104.75   1.3962889   23500.66    16830.8 0.74865216     9864.75    13176.68   1.0848985   12954.6    11940.84   0.7067568    11866.65    16790.29   1.1800476    8907.79    7548.67
                       647.78     844.37    0.7215697     836.09    1158.71    0.8812301     334.7     379.81    1.461007     323.54     221.45    0.8819976      576.65      653.8    0.92651284    447.83     483.35
                      3455.36    2661.55 0.65500426      1669.37    2548.64    1.3000525   1311.22    1008.59    1.1477883   1340.41    1167.82 0.80245185        994.31    1239.09 0.97026634      1022.03    1053.35
                     37740.45    30151.07   2.065743    43164.71    20895.49   2.152008    8958.83    4163.01    1.0293082   12641.87   12281.91   0.7508139    48144.32    64122.84   0.6778172     7722.1    11392.6
                     70962.17      64385    1.9616803   50015.04    25496.02   1.0758779   28107.03   26124.74   0.5954191   19140.3    32145.93   0.6541625    48328.76    73878.83   1.0895492    23979.92   22009.03
                                            1.1022048      589.9      535.2    3.4411764    139.23      40.46                                      1.1529119     1550.24    1344.63 0.71535873       305.73     427.38
                     10986.96    7279.54    1.4463143    3922.94    2712.37    2.620399    4258.62    1625.18    1.2232865    809.62     661.84     1.444232    10851.67     7513.8    0.8113564    2899.09    3573.14
                        802.2    1465.71 0.71011996       6299.9     8871.6     4.04994      5255     1297.55 0.98164666     4064.95    4140.95    1.5140809     9857.03    6510.24    1.0155582    7449.16    7335.04
                      3748.04    3763.16    1.2704041    3540.07    2786.57    0.9584662   1419.22    1480.72 0.59403634     1108.05    1865.29    0.5721767     6490.04    11342.72 0.79694194     1758.03    2205.97
                       2567.3     2851.2 0.77182394      2166.78    2807.35 0.54005384      366.81     679.21    2.382023     297.61     124.94     1.025709      687.82     670.58    1.1879606     657.75     553.68
                     1321.49    1468.13    0.8954155     810.36     905.01 0.92961764      436.66     469.72    1.0254012     569.19     555.09 0.85053873       960.76    1129.59 0.97065437     1571.47    1618.98




                                                                                                                                                                                                                  UNCORRECTED PROOF
                      535.12     497.13 0.72723913      1729.52     2378.2    1.3620813    325.66     239.09                                       1.1833005    4162.65    3517.83    1.0853733   2341.53    2157.35
                      337.72     305.14 0.88307935      1117.74    1265.73    1.0883279    383.69     352.55    1.3680594     292.71     213.96 0.95773345       681.82     711.91    0.7938705    701.98     884.25
                     2400.94    2135.69 0.74188066      1117.71    1506.59 0.34692705     1367.59    3942.01     1.486109    1048.45      705.5    1.2889158    1319.36    1023.62    1.9293908    507.97     263.28

                      599.56     797.46    0.8813047    1247.76    1415.81 0.39054757      888.32    2274.55    0.8712892     750.18       861     1.2845266    1022.83     796.27    1.0295606    657.22     638.35
www.molmed.org



                       19.67     166.71    0.8314714    1970.08    2369.39 0.64922696      330.45     508.99     1.118291     326.91     292.33     0.988642    3209.28    3246.15 0.87076575     1314.36    1509.43

                     9961.45    7868.43 0.98194087      6960.91    7088.93    1.3486661   7110.68    5272.38     1.386622    4728.27    3409.92    1.2177663    18701.03   15356.83   1.2525214   6655.11    5313.37

                     1452.08     1781.7    0.7730784    5286.99    6838.88 0.77193075      1862.8    2413.17    1.3165084    2697.71    2049.14    1.3019117    7458.04    5728.53    1.3156815   2663.65    2024.54
                     1601.09    1877.08      0.85508    1694.76    1981.99 0.89139706      484.92        544    1.2330395     762.08     618.05    0.8023736    1373.15    1711.36 0.89871943      787.44     876.18
                     12208.86   12502.11    1.441569      18278    12679.24   0.5099002    5669.8    11119.43    1.727202    12650.58   7324.32 0.78363734      20144.37   25706.24   1.2702819   5962.78    4694.06
                      542.53     441.69 0.97754216       647.26     662.13 0.90161693      441.63     489.82    0.9858162     328.75     333.48    1.0566936     308.47     291.92 0.55357206      312.58     564.66
                     56969.72     64385    0.99179566   40290.83   40624.12   1.421717    31164.28   21920.17   1.3146198    28961.65   22030.44 0.96026725     59080.08   61524.62   1.7233005   19205.15   11144.4
                     12745.87   19056.13    2.030318    32842.2    16175.89   1.9449725   2838.59    1459.45 0.71617013      5434.75    7588.63    0.6574211    6479.95    9856.62    0.8292185   1771.02    2135.77
                     7446.03    6917.08     1.188782    2606.88     2192.9    0.9615181   2062.11    2144.64    0.7557712    2423.35    3206.46    0.9369575    7570.12    8079.47    0.9268669    3053.6    3294.54
                      1835.2    2144.91 0.93573797      3854.81    4119.54    0.8003618   5087.46    6356.45    1.7939899    3159.88    1761.37    1.5937656    18235.34   11441.67   1.5276612   8474.64    5547.46
                      232.89     129.91    0.7343453     644.88     878.17 0.51792544      655.01    1264.68                                       1.1754975     962.18     818.53    0.7452546    343.54     460.97

                      446.85     566.28 0.67605275       509.71     753.95 0.22907075      273.68    1194.74    1.0373757      77.16      74.38    0.68645126    357.14     520.27    0.8704224    470.15     540.14
                      458.68     464.53    0.8922015    1307.45    1465.42    1.1739303    237.31     202.15                                        0.545582    2284.51    4187.29    0.5856722    292.35     499.17
                      581.55     683.59    0.8126863     755.14     929.19    1.1248959    499.96     444.45     1.483389     226.38     152.61    0.6963658     946.18    1358.74    1.0573108    226.55     214.27
                     35060.28   28868.32   1.3355705    17009.57   12735.81   1.1747668   3879.35    3302.23    0.7295538    9457.49    12963.39 0.46632913     3928.38    8424.05    0.6432249   3303.77    5136.26
                     6284.86    5406.16     1.050113    2766.88    2634.84    3.5927727   3563.42     991.83    1.3381766    2842.14    2123.89    2.8477967    4441.88    1559.76    1.2493912   3935.02    3149.55
                     5193.26    5307.31    1.0602013    4181.01     3943.6    1.2968872   1635.66    1261.22    0.9107545    2177.96    2391.38     0.984856    9025.19    9163.97    1.4511057   2905.81    2002.48
                     1756.66    2026.56    1.0665536    2542.44    2383.79 0.86150676     1284.92    1491.48    1.1564469    1484.82    1283.95    0.8762657    4316.66     4926.2    1.1641321   1676.49    1440.12
                      580.85     809.62    1.3736091    2065.18    1503.47    0.9107847    909.71     998.82    1.1310146    1476.63    1305.58 0.74398434      1186.35    1594.59    1.0379094    938.54     904.26
                     23198.54   23273.69   1.3043544    9732.05     7461.2 0.90957314     9603.41    10558.15 0.93888044     4219.01    4493.66    1.3715873    31974.06   23311.72   1.1214417   12328.86   10993.76
                      157.21      46.71    0.8373353     666.05     795.44    1.4738641     99.25      67.34    0.44774622     26.82       59.9    0.8026267    10918.06   13602.91     0.9003     6347.7    7050.65
Molecular Medicine




                     46380.1    43354.76    2.385483    50984.76   21372.93 0.61587095    8765.26    14232.3     1.138967    19982.95   17544.8 0.32421613      34400.53   106103.7   1.0646777   23607.8    22173.66
                      847.22      899.4     1.066067    1632.01    1530.87    0.9755899    633.87     649.73                                       2.0864255    7156.21    3429.89 0.88830435     1428.58    1608.21
                     9787.07    7767.38    1.8237994    5285.48    2898.06    0.8278279    861.33    1040.47 0.67059696       757.56    1129.68    0.8013793    2686.52    3352.37    0.8536001   1913.08    2241.19
                       246.6     371.55     0.682467      664.6     973.82 0.40210277      207.67     516.46 0.36799267        60.13      163.4    0.95655406    708.07     740.23 0.65057087      360.13     553.56
                     10077.48   14392.27    1.473894    17989.23   12205.24   0.9168161   8159.04    8899.32 0.37104142      4361.64    11755.13   1.5609086    68366.44   43799.13   0.6609099   5483.53    8296.94
                     4399.49    4455.22    1.8289337    11821.88   6463.81    0.6957797   2400.92    3450.69 0.90437144      3073.38    3398.36    0.6420558     9295.8    14478.18   0.8056494   2451.14    3042.44
                     36203.98   24861.4    3.9876623    73982.9    18552.95   0.6361114   3555.92    5590.09    1.7498837    10863.61   6208.19 0.37783217      22262.33   58921.21   0.7305139   3986.21    5456.72
                      617.72     521.71    1.1669967    1708.95     1464.4    1.1977187   1158.17     966.98 0.55988437         457      816.24     1.128968    2435.85    2157.59    0.7426724   1032.53    1390.29
                      1413.5    1554.73    0.7752644    1028.52    1326.67 0.65301687      327.71     501.84                                       0.7956517    2620.59    3293.64    0.7537211     762.6    1011.78
                     28193.26   30922.33   1.4433439    20918.57   14493.13   0.7542682   6866.33     9103.3    0.8037269    4466.72    5557.51    1.1649897    41155.1    35326.58   0.9386876   18619.79   19835.98
                       124.4      73.36    0.60684294    469.66     773.94 0.37086105      193.99     523.08 0.16660465        17.91      107.5     1.284349     649.02     505.33 0.64531064      300.96     466.38
                     4418.75    5501.06    1.1459355    13418.47   11709.62   1.1770366   6921.27    5880.25    1.2753923    10923.25   8564.62    1.0032601    11598.52   11560.83   1.1516658   8153.84    7080.04
                     15870.51   13672.29   0.6254256    21830.83    34905.56   1.3151629   13737.64   10445.58   1.1674933    10060.56   8617.23    1.0509467    16963.74   16141.39   1.6865036    14331.47   8497.74




                                                                                                                                                                                                                    UNCORRECTED PROOF
                     29001.38   38255.04   1.1531647    31661.96    27456.58   2.1310358   19828.84   9304.79 0.73816985      16712.27   22640.14   1.0400536    33554.51   32262.29   1.0806911    14579.42   13490.83
                     15075.48   17065.59   0.6462096    11292.59    17475.12 0.50641716    6408.38    12654.35   0.5732741     8006.5    13966.27 0.58954966     5237.17    8883.34     1.017583    10362.16   10183.11
                      987.97     725.47 0.99722415       1095.72    1098.77    5.6326675    403.13      71.57    1.4546688     674.85     463.92     1.049597    3606.72    3436.29    1.0903174    1278.07     1172.2
                                           0.98109275     517.34     527.31 0.92065775      147.25     159.94    2.1583881     177.29      82.14    1.1444157     483.55     422.53 0.48291627       120.42     249.36
                     12842.01   15694.33   1.9149611    15861.01    8282.68 0.63281924     4833.41     7637.9 0.56748766      7671.99    13519.22   1.4126978    10666.25   7550.27    1.0859394    5552.43    5113.02
www.molmed.org



                     9539.01    11393.89   1.7317113    11101.17    6410.52 0.68156165     4086.78     5996.2    1.0305003    6745.13    6545.49    0.7876816    15074.87   19138.28   0.9918031    7806.75    7871.27
                      394.29     253.53    0.7822773      745.08     952.45    0.7180431     436.8     608.32                                       1.5663936    1745.73    1114.49    0.72304267    500.36     692.02
                      376.59     396.32    0.7243043      457.84     632.11    0.6904147    221.92     321.43    3.4946609      91.63      26.22    0.8673226     392.29