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BIOGRAPHICAL SKETCH NAME POSITION TITLE Slover, Robert H. Director of Pediatric Services eRA COMMONS USER NAME (credential, e.g., agency login) Wagner Family Chair in Childhood Diabetes RSLOVER Associate Professor of Pediatric Endocrinology EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Brigham Young University B.S. 6/1971 Pre-Med Provo, UT University of Utah Medical School M.D. 6/1975 Salt Lake City, UT Medicine Fitzsimons Army Medical Center 7/1975- Aurora, CO 6/1976 Intern Fitzsimons Army Medical Center 7/1976- Pediatric Resident Aurora, CO 6/1978 University of Colorado Health Sciences Center 7/1980- Fellowship Denver, CO 6/1982 A. Personal Statement I have the expertise, leadership, and motivation necessary to successfully carry out the proposed work. I have a long and broad background in pediatric endocrinology and specifically in Type 1 diabetes with specific expertise and training in key research areas needed for this study. My specific research work in the past few years has been in the area of insulin pump and sensor use, including the use of sensor augmented pump as compared to multiple daily injections (Star 3 Study) in which I was PI. I am currently PI of a study using a ePID closed loop system in newly-diagnosed patients to rapidly achieve tight control in order to extend islet cell life and C-peptide production (Artificial Pancreas Consortium/Trial Net). I am also currently PI for a study using a modified closed loop pump/sensor system to shut off insulin delivery at the point of hypoglycemia during exercise. I have successfully administered these and other projects ( e.g. staffing, research protection, budget), collaborated with other researchers, and have participated in or authored several abstracts, posters, and peer-reviewed publications from these projects. As a result of these previous experiences, I am aware of the importance of frequent communication among project members and of constructing a realistic research plan, timeline, and budget. In summary, I have demonstrated a record of successful research in an area of high relevance to this current project. B. Positions and Honors Positions and Employment 1978-1994 United States Army, Pediatric Endocrinologist 1982-1990 Clinical Assistant Professor, University of Colorado, Denver, CO 1982-1994 Chief, General Pediatric Services, Fitzsimons Army Medical Center, Aurora, CO 1984-1994 Clinical Assistant Professor, Bethesda, Maryland 1990-1998 Assistant Professor, University of Colorado, Denver, CO 1998-1999 Associate Professor, University of Colorado, Denver, CO 1999-2002 Mission President, South Korea 2002-2010 Associate Professor, University of Colorado, Denver, CO 2011-Present Director of Pediatric Services, Barbara Davis Center for Childhood Diabetes, Denver, CO 2011-Present Wagner Family Chair in Childhood Diabetes, Denver, CO Other Experience and Professional Memberships Member, American Diabetes Association Member, Pediatric Endocrine Society Member, The Endocrine Society Member, Western Society of Pediatric Research Member, International Society for Pediatric and Adolescent Diabetes Member, American Academy of Pediatrics Member, Society for Uniformed Endocrinologists 2004-Present Faculty Senate, University of Colorado Health Sciences Center, Aurora, CO Honors Alpha Omega Alpha National Medical Honor Society Department of Pediatrics Outstanding Teacher Department of Pediatrics Outstanding Teacher C. Selected Peer-reviewed Publications (selected from more than 250 published papers) 1. Bergenstal R, Tamborlane W, Ahmann A, Buse J, Dailey G, Davis S, Joyce C, Peoples T, Perkins B, Welsh J, Willi S, Wood M. Effectiveness of Sensor-Augmented Insulin-Pump Therapy in Type 1 Diabetes. The New England Journal of Medicine. 2010 July, 363(4):311- 320. 2. Scrimgeour L, Cobry E, McFann K, Burdick P, Weimer C, Slover R, Chase HP. Improved Glycemic control after long-term insulin pump use in pediatric patients with type1 diabetes. Diabetes Technol Ther. 2007 Oct: 9(5):421-8. 3. Chase HP, Horner B, McFann K, Yetzer H, Gaston J, Banion C, Fiallo-Scharer R, Slover RH, Kligensmith GJ. The Use of Insulin Pumps with Meal Bolus Alarms in Children with Type 1 Diabetes to Improve Glycemic Control. Diabetes Care 29:1012-1015, 2006. 4. Barker JM, Goehrig SH, Barriga K, Hoffman M, Slover R, Eisenbarth GS, Norris JM, Klingensmith GJ, Rewers M; DAISY study. Clinical characteristics of children diagnosed type 1 diabetes through intensive screening and follow-up. Diabetes Care. 2004 Jun; 27(6):1399- 404. 5. Burdick J, Chase HP, Slover RH, Kneivel K, Scrimgeour L, Maniatis A, Klingensmith GJ. Missed Insulin Meal Boluses and Elevated Hemoglobin A1c Levels in Children Receiving Insulin Pump Therapy. Pediatrics; 113(3):221-224, 2004. 6. Chase HP, Slover RH, Burdick J, Knievel K, Scrimgeour L, Maniatis AK, Klingensmith GJ. Missed Insulin Meal Boluses and Elevated hemoglobin A1c Levels in Children Receiving Insulin Pump Therapy. Pediatrics. 2004 Mar; 113(3 Pt 1):e221-4. 7. Redondo MJ, Taylor J, Weiner M, Behnke S, Yu L, Miao D, Haas JE, Slover R, Eisenbarth GS, Klingensmith GJ, Hoffenberg EJ, Rewers MJ. Transglutaminase autoantibody screening for celiac disease of children with type 1 diabetes. Diabetes Care, 2003. 8. Roberts MD, Slover RH, Chase HP. Diabetic ketoacidosis with intracerebral complications. Pediatric Diabetes; 2:109-114, 2001. 9. Maniatis AK, Klingensmith GJ, Slover RH, Mowry CJ, Chase HP. Continuous Subcutaneous Insulin Infusion Therapy for Children and Adolescents: An Option for Routine Diabetes Care. Pediatrics; 107:2, 351-356, 2001. 10. Rutledge, KS, Chase, HP, Klingensmith, GJ, Walravens, PA, Slover, RH, and Garg, S.K. Effectiveness of postprandial humalog in toddlers with diabetes. Pediatrics 100:968-972, 1997. 11. Slover, RH, Eisenbarth, GS: Prevention of type I diabetes and recurrent beta-cell destruction of transplanted islets. Endocrine Reviews 18:241-258, 1997. 12. Sakkal-Alkaddour, H, Zhang, L, Yang, X, Chang, YT, Kappy, M, Slover, RH, Jorgensen, V, Pang, S: Studies of 3B-Hydroxysteroid dehydrogenase (3B-HSD) genes in infants and children manifesting premature pubarche (PP) and increased ACTH stimulated delta 5 steroid levels. Clinical Endocrinology and Metabolism 81:3961-3965, 1996. 13. Slover, RH, Klingensmith, GJ, Gotlin, RW, Radcliffe,J: A comparison of clonidine and standard provocative agents of growth hormone. Amer J Dis Child 38:314-317, March 1984. 14. Diabetes & Metabolism [Slover, Robert, H. – Study Group Member]. New Injection recommendations for patients with diabetes. El Sevier Masson Vol. 36; 3-18, September 2010. 15. Diabetes & Metabolism [Slover, Robert. H.- Study Group Member]. The Third Injection Technique Workshop in Athens (TITAN). El Sevier Masson Vol. 36; 19-29, September 2010. D. Research Support Ongoing Research Support CEP235/Z25 Slover (PI) 5/1/2010-4/30/2013 X-54, Low glucose suspend feature The goal of this study is to assess the automatic suspend feature of a partial closed-loop system during exercise in adults and older adolescents. Role: PI ETP08-2448 Slover (PI) 2/22/2010-03/21/2013 MySentry™ remote monitoring system user evaluation The goal of this study is to assess feasibility of use of a remote alarm for a continuous glucose monitoring system in a pediatric population. UOl HD41890: Slover (PI) 5/1/2009-10/31/2014 Metabolic control at onset of type I diabetes The goal of this study is to investigate the hypothesis that achievement of extremely tight control through use of a closed-loop system within the first week of diagnosis in patients with Type 1 diabetes will prolong beta cell life. (DirectNet). Completed Research Support Slover (PI) 6/1/2007-6/30/2010 Star 3 study The goal of this study is to compare glucose control over a 12 month period between patients using multiple daily injections and those using sensor augmented pump therapy.
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