Australasian perspective
Anna deFazio
National and
international
Multi-site biobank
biobanks networks and
consortia
Departmental
/ Institutional
biospecimen
banks
Biospecimen
collections
1980 1990 2000 2010
Institutional / Departmental collections
Clinical Trials
◦ eg. Ludwig Institute, Sydney Branch
Frozen tissues (eg. Ludwig Breast Trials)
Plasma – pharmacokinetics (clinical trials)
Pathology Archives
1983: 2151 citations
Frozen tissue collections
1983
1986
Increase in the number of Departmental / Institutional
collections and consolidation of dedicated ‘banks’
specifically established to collect biospecimens, available
for research
eg.
1992 Gyn Oncology Tissue Bank, Westmead
1997 The Kathleen Cuningham Foundation Consortium for Research into
Familial Breast Cancer (kConFab)
1998 Peter Mac Tissue Bank
1998 Children’s Hospital Westmead, Paediatric Tumour Bank
The last decade has seen an increase in funding for biospecimen
banking in general
Oncology: Filling the gaps in tumour types, enabling established banks
to increase the quantity and quality of their collections and increase the
provision of biospecimens for research
eg.
◦ 2002 Australian Ovarian Cancer Study
◦ 2002 NSW Pancreatic Cancer Network Tissue Bank
◦ 2002 National Leukaemia and Lymphoma Tissue Bank
◦ 2002 Singapore Tissue Network (STN)
◦ 2003 Australasian Biospecimen Network
◦ 2004 Australasian Biospecimen Network:Oncology
◦ 2005 Australian Prostate Cancer Collaboration (APCC)
◦ 2006 Breast Cancer Tissue Bank (BCTB)
◦ 2006 Victorian Cancer Biobank
◦ 2007 Sydney Melanoma Unit Bio-Specimen Bank
The last decade has seen an increase in funding for biospecimen
banking in general
Oncology: Filling the gaps in tumour types, enabling established banks
to increase their quantity and quality of their collections and increase
the provision of biospecimens for research.
eg.
◦ 2002 Australian Ovarian Cancer Study*
◦ 2002 NSW Pancreatic Cancer Network Tissue Bank
◦ 2002 National Leukaemia and Lymphoma Tissue Bank*
◦ 2002 Singapore Tissue Network (STN)
◦ 2003 Australasian Biospecimen Network
◦ 2004 Australasian Biospecimen Network:Oncology*
◦ 2005 Australian Prostate Cancer Collaboration (APCC)*
◦ 2006 Breast Cancer Tissue Bank (BCTB)*
◦ 2006 Victorian Cancer Biobank
◦ 2007 Sydney Melanoma Unit Bio-Specimen Bank
*NH&MRC Enabling Grants
‘The scheme supports excellent facilities and/or
activities where there is a clearly demonstrated
national need for the particular facilities and/or
activities in order to underpin aspects of the
national health and medical research effort’
Over 20 special facilities related to biospecimens
banking funded including:
◦ National Network of Brain Banks
◦ Australian Motor Neuron Disease DNA Bank
◦ Australian Schizophrenia Research Bank
◦ Australian Childhood Diabetes DNA Repository
◦ The Western Australian DNA Bank
◦ Genetic Repositories Australia - a central national facility for
establishing, distributing and maintaining the long-term
secure storage of human genetic samples.
The ABN is a non-profit scientific organisation with voluntary
membership in Australia and New Zealand
PURPOSE: to provide a forum to address technical, legal / ethical,
and managerial issues relevant to human biospecimen repositories
within Australia and New Zealand.
Statement of Purpose
To provide an opportunity for individuals who have an interest in
tissue banking and biorepositories to come together to share
relevant and non-confidential information to assist in improving their
operational efficiencies
To provide education and technical assistance to individuals new to
the area of biorepositories
To provide a structure and focus around which the Australasian
Biospecimen Network Association will continue to expand and
attract a diverse range of members within the broad biobanking
community of Australia
ABN-Oncology
D. Catchpoole, J. Creaney, A. deFazio,
L. Devereux, A. Matusan, C.
Schmidt, H. Thorne, N. Zeps
Australian Mesothelioma Tissue Bank
kConFab
Peter MacCallum Cancer Centre Tissue Bank as part of Victorian Cancer
Biobank
Queensland Institute of Medical Research Cell Line Bank
Queensland Institute of Medical Research Tissue Bank
The Tumour Bank at Children’s Hospital at Westmead
West Australian Research Tissue Network at Saint John of God Hospital
Westmead Gynaecological Oncology Tissue Bank
Local, national and international linkages
ABN-Oncology
ABN Member Banks Scientific
Biospecimen and data collections Advisory
Management Executive Board
Researchers
Tissue and data requests
ABN Hub Manager
Assists researchers and tissue banks
Disseminates tissue banking information
Manages the ABN website
ABN Web site
Tissue Locator
Protocols
‘Help Desk’
www.abrn.net ‘New’ ABN Affiliated Banks
8000
Total Tissue Collection Events
7000
6000 Actual
5000
4000
3000
Estimated
2000
1000
0
Nov 04 Nov 05 Nov 06 Nov 07 Nov-08 Nov-09
Month
1400
Tissue Collection
1200
1000
800
600
400
200
0
Tumour Type
ABN-oncology member banks have supplied
biospecimens / data to over 130 projects
resulting in 138 publications over the last 5 years
Tumour profiles
Life-style, diet,
Inherited
environment
genes
Clinical outcome
Expression profiles
Risk Factors
Genomic gain / loss
Mutations
Genes Environment Lifestyle / Diet
Epigenetics
SNPs
Mutations
Treatment
Linkage of biospecimens with
high quality patient data
Cancer Australia – working with ABN and other tissue banks to develop
recommended clinical dataset, with common data definitions, for
biospecimen banks.
CheReL - The Centre for Health Record Linkage established in 2006 to
create and maintain a record linkage system for health and human
services in NSW and the ACT.
BioGrid Australia and the Australian Cancer Grid (ACG) - a virtual
repository which will link to all participating teaching hospitals and
cancer research centres in Australia as well as the integrated cancer
centres in Victoria.
The Australian Ovarian Cancer Study experience
Control recruitment Patient recruitment
Lifestyle and dietary
Blood Tumour sample Clinical details
questionnaires
Epidemiology Biospecimen Clinical Follow-up
Core Core Core
Penny Webb David Bowtell Anna deFazio
Recruitment 2002 - 2006
• 1,859 women with ovarian, fallopian tube and primary peritoneal cancer recruited through
treatment centres & cancer registries across Australia (1,097 frozen tissues)
• 1,066 control women recruited, selected at random from Commonwealth electoral roll
AOCS Centres
Mater Misericordiae
Royal Women’s
Townsville
Wesley
Hunter
Royal Hospital for Women
Royal North Shore / Private
King Edward Memorial Royal Prince Alfred
St John of God Westmead
Freemasons
Mercy Women’s
Burnside War Memorial
Royal Hobart Monash Medical
Flinders Medical Centre
Centre
Royal Adelaide Hospital
Royal Women’s
L
S E N S T
I I
V E
6 0 1 3
H is o
t lo g y :
S e r o u s a d e n
1 0 0 F 0 I 0
G O 0 S t
a g e C
:
I ( S a
t g e D e a
t
5
R e s id u a lD is e a s e :
m a c r
R E P S r P im O a N r S y E T r e a m
t e n :
C
t
S e c o n d L i
n e :
R e s p o n s
2
1 0 0 T 0 h 0 i
r d L n
i e N
: o R e s p o n s
F o u r h
t L i
n e :
R e s p o n s e
Serum CA125 level
1
1 0 0 0
U p p
A
C A 1
C a r
1 0 0 P a c
C
D o x
G e
S u r
1 0 R e l
a
1
F M e A Nb u Fa o- Mg ey Av - N b- u - Fa o - Mg e y Av - N b - u - Fa o - Mg e y Av - Nb - u - Fa o- Mg e y Av - Nb - u - Fa o - Mg e y v - b- - a - y
0 0 3 0 3 0 3 0 3 0 4 0 4 0 4 0 4 0 5 0 5 0 5 0 5 0 6 0 6 0 6 0 6 0 7 0 7 0 7 0 7 0 8 8
D a t e
• Clinical follow-up at 6 month intervals (GCP guidelines)
• Date of relapse assigned according to GCIG criteria (CA125)
• Treatment response assigned according to GCIG criteria
AOCS Centres Bundaberg
Cairns
Gold Coast
Hervey Bay
Mackay
Mater Misericordiae
Maryborough
Royal Women’s
Rockhampton
Townsville
Sunshine Coast
Wesley
Toowoomba
Townsville
Hunter Armidale
Royal Hospital for Women Bathurst
Royal North Shore / Private Canberra
King Edward Memorial Royal Prince Alfred Coffs
St John of God Westmead Harbour
Dubbo
Grafton
Bunbury Goulburn
Mandura Illawarra
Freemasons
Mercy Women’s Lismore
Burnside War Memorial Moruya
Royal Hobart Monash Medical
Flinders Medical Centre Orange
Centre Austin
Royal Adelaide Hospital Tamworth
Royal Women’s Bendigo Tweed Heads
Echuca
Frankston
Launceston Geelong
Whyalla Hamilton
Darwin Mildura
Mornington
Taralgon
Wodonga
October 2009
• 1,882 eligible cases
• 14,338 case report forms
• 746 (39%) eligible cases deceased
• 474 patients have completed 5 years
follow up
• 89 (4.7%) patients lost to follow-up
RN
completes
CRFs
CFU Queries /
Manager forwards
CFU
Database
Residual disease nil or ≤1 cm (n=414) Residual disease >1 cm (n=122)
Median Progression-free Survival
GG 18.3 months Large cohorts
Biospecimens
GA/GT 26.6 months
Detailed treatment details
TT/TA 38.5 months
Accurate clinical outcome data
*Johnatty SE et al. Clin Cancer Res 14: 5594–601, 2008
Network biobanks to facilitate the collection biospecimens for clinical trials
ABN-Oncology has already provided support for 34 national and
international clinical trials - supporting the collection of biospecimens for
trials including TARGiT, IBIS, IMPACT, GOG199
ABN-Oncology working with COSA (Clinical Oncology Society of Australia)
to map out mechanisms / pathways to facilitate collection of biospecimens
via biobank networks
National and
Multi-site international
biobanks biobank
networks and
Departmental consortia
• Consolidation of biobank networks
/ Institutional
• Efficient linkage with patient /
biospecimen
banks
participant data
Biospecimen
• Informatics: web-based access to
collections
de-identified research data linked
to biospecimens
1980 1990 2000 2010
ABN-Oncology: Dan Catchpoole, Jenette Creaney, Lisa Devereux,
Anita Matusan, Chris Schmidt, Heather Thorne, Nik Zeps
Australian Ovarian Cancer Study: David Bowtell, Adele Green,
Georgia Chenevix-Trench, Penny Webb, Dorota Gertig, Nadia
Traficante, Sian Fereday, Laura Galletta, Jillian Hung, research
nurses, clinicians
Funding: NHMRC, State Cancer Councils, Cancer Australia, US
Department of Defence
Collection protocols
◦ A guide for developing tissue banks
◦ Consent, Tissue, Blood, Cell Lines, QA, Access Policies
◦ Completed October 2005, reviewed 6 monthly
◦ Available at www.abrn.net/protocols.htm
Clinical Trials: Enable collection of material for clinical trials, using
existing infrastructure, on a contract basis.
Web-based ‘Tissue Locator’: Allows researcher to search for
currently available specimens on line